Submmited to: prof.

kunal joshi
 Flying view of company

1972 - The Company was incorporated on 15th July, as a Private Limited Company
by Shri Rajnikant C. Patel and his family members, and in June 1982, the company
was acquired by Shri Uttamlal N. Mehta.

- The Company is primarily engaged in the manufacture of various Pharmaceuticals

formulations and bulk drugs. The products of the Company enjoy good reputation
and are well accepted in the market.

- The Company has taken up manufacture of bulk drugs as a strategic value added
backward integration to its formulation activities.

1989 - On 28th June the Company became a deemed Public Company under the
provisions of Section 43-A of the Act and by a Special Resolution passed on 25 th
July, 1992 at the Annual General Meeting, the Company became a Public Limited
Company within the meaning of Section 3(1)(iv) of the act and adopted a new set of
articles.

1992 - Torrent Laboratories Limited, was amalgamated with the Company with effect
from 1st April by an order of the Honourable High Court of Gujarat, dated 22nd
December.

- The Company proposes to undertake an expansion-cum modernization of its

existing facilities, setting up facilities for manufacture of new products apart from
setting up a separate in-house Research & Development Centre.

- The Company further broad base its product range through in-house manufacture of
Ranitidine HCL, Diltiazem, HCL and Atenolol with an installed capacity of 12 tpa
each.

- The company proposes to set-up in-house production facilities for Large Volume
Parentrals with an installed capacity of 14.5 million bottles p.a. for better quality
control and for diversifying the product range to include dextrose/saline injectibles
and value added items like fluconazole infusion.
 2006

-Torrent Pharma Receives USFDA Approval

-Torrent’s Azuca launches 2 new blockbusters, Pregeb and Piopod

-Entered into an in-licensing deal with Tasly of China to market its Cardiotonic pill in
India
-Torrent Pharmaceuticals Ltd has announced that the Company has
launched Nexpro Fast (Immediate Release Esomeprazole), a Proton Pump
Inhibitor (PPI), for the first time in India to treat peptic ulcers
and GERD (Gastro Esophageal Reflux Disease).
-The API and formulations manufacturing facilities located at Indrad
(Gujarat, India) got US FDA approval
-Torrent Pharma launches AzuCa, its super-specialty Diabetes
division

2007

- Torrent unveils laxative in tablet form

-Torrent Pharma launches CVpill, The world’s first ‘polypill’ in

Cardiac care

-Indians to get slimmer and fitter: Torrent Pharma launches Rimoslim;

India’s first Rimonabant

-Torrent Pharma launches Fibotab; India’s first bulk laxative in

tablet form

2009

-Torrent’s New Insulin Facility to produce 26 million vials pa for

Novo Nordisk

   

Overview ::

Torrent’s manufacturing facility at Indrad, Gujarat, was set up in

1989. Today, the Indrad facility is at par with international standards.
It complies with WHO, cGMP, MHRA and TGA norms and has
received ISO 9001, ISO 14001 and OHSAS 18001 (Occupational
Health and Safety Management System) certifications; adequately
reflecting Torrent’s commitment towards quality and safety.
Attainment of such standards have also opened the key to gaining
footholds in regulated, lucrative markets like the US and EU for
Torrent Pharma.

Torrent firmly believes that quality can not be talked into a product,
but has to exist inherently. Its efforts towards realizing world-class
quality standards came into limelight with the “Quality Excellence
Gold Award” received from the Indian Drug Manufacturers’
Association (IDMA) for four consecutive years viz. 2000, 2001,
2002 and 2003. 

Infrastructure ::

 Land - 178,000 sq. metres

 Built-up Area - 50,000 sq. metres for Formulations, 10,000 sq.
meters for API
 Excellent Support Services
 Finished Products - Oral Dosage Form, Injectables, Freeze
Dried Sterile Injections
 API - Multi Product, Versatile Facility, Upgraded to
International Standards
 Hygiene Zones – Process step dependent special zones created
for each type of activity

Manufacturing Capacities (per annum) ::

Formulations - Tablets, 6,000

capsules and vials million
Bulk Drugs/API 15,000 kg
Tie-up with Novo Nordisk ::

We have signed an agreement with Novo Nordisk India in August

2005 and part of our parenteral facility is dedicated for the
formulation and packaging of Insulin, exclusively for Novo Nordisk.
The facility will cater to the increased demand for Novo Nordisk
 Insulin products in India and will incorporate state of art technology
in formulation, filling, inspection and packaging of Novo Nordisk
insulin formulations. 

This facility will have the requisite flexibility to expand and the
production will be done with the same state of the art technology and
quality standards as practiced across the world by Novo Nordisk. 

We have been manufacturing Insulin for Novo Nordisk’s India

requirement for more than 15 years now. Our parenteral site for
insulin production is dedicated for Novo Nordisk products, and
complies with their worldwide norms. On numerous occasions, we
have won the award for Best Maintained Manufacturing Site of Novo
Nordisk worldwide.

Distribution

A well functioning distribution system is a pre-requisite in any consumer goods

industry and more so in pharma due to limited shelf life of products. This area has
been under continuous focus for improvement. The key initiatives for the year
involved automating the processes at various levels in the supply chain system and
improving the flow of data for market planning and control. The debtors credit and
collection system was also completely overhauled resulting in a considerable
reduction on overdue debtors. The Value Added Tax (VAT) was proposed to be
introduced by all the State Governments from April 2003 in replacement of the
current sales tax laws. As in the past, this was once again postponed. VAT has
created considerable confusion and uncertainties amongst the trade channel and is
repeatedly affecting the primary sales of the Company. In the medium term, the
implementation of VAT is also expected to result in a restructuring of the
distribution structure, for which your Company is gearing up.
 Sales Force Automation System : Development, Rollout and Change
Management

Sales force management systems are information systems used in marketing and
management that automate some sales and sales force management functions. They
are frequently combined with a marketing information system, in which case they
are often called customer relationship management systems.

When I was employed with Torrent Pharmaceuticals Limited

(www.torrentpharma.com), SFA was the first project I got to work on. Torrent has
over 800 products registered in over 27 countries. Torrent created an IT enabled
Business Environment through deployment of SAP in its headquarter, two
manufacturing plants, one research center and numbers of foreign subsidiaries.
But, people who were always on move, who really generated the sales for the
company - the strong sales force of 3000+ people; did not get any direct benefit of
this IT enabled Business Environment. For them, a separate system catering to
their specific needs was required. That gave birth to idea of SFA roll out.

Our business case was:

1. Wanted to minimize/eliminate writing work
2. Improve productivity
3. Better Customer, Business, Industry focus
4. Data capturing at source
5. Immediate feedback from seniors
6. Free up time for high value activities
7. Morale of field force
8. Online availability of Sales, Goods return and stock data
9. Torrent news from HO/Market
10. Discussion forums
11. E-Mail & Medical Information
12. Increase in productivity & earnings
13. Overall – Gain Competitive Advantage
 Approach to a problem & Change Management

Following figure illustrates the hierarchy of Sales Force

Typically, in other pharma companies, requirements were gathered from HQ; who
does not know actual problems in field, develop the system and then force the
system on sales force. These were always a failure. But, we took different pathway.
We wanted to involve Sales Force - the actual user; in every phase of development.
We wanted them to own the system. We selected a team of actual users for pilot
testing. And then...

 Launched the system for one zone at a time

 First zone with only basic functionality
 Every next zone with improved interface and useful features developed with
input from previous zones
 Sufficient training and testing time given before LIVE date for each zone
 Time gap between two zone going LIVE
Following figure illustrates the SFA Architecture
In our training to sales force, we also faced problem like people with zero
computer literacy. We treated them separately by giving them computer knowledge
first. 24 Hours telephonic support was given. In initial roll out, many time I
received calls for support around 2AM during month end(closing time).

In the end, I and my team were gained by the knowledge of functions and sales life
cycle of a pharmaceutical company. But, most important to us was, we were able
to simplify life of sales representatives; that was our real success.
Supply Chain Management Facility ::

Supply Chain Management activities at the manufacturing plant mainly include:

Production Planning / Inventory Control / Warehousing / Information Technology.
It coordinates with the Procurement Division for timely availability of inputs and
with Marketing Department to make all products available timely, as per the
requirements, and distribution of products to C & F Agents all over the country,
and of finished goods to Cargo Handling Agents for exports.

Production Planning and Control :: It is one of the core functions of all the
manufacturing activities

    Activities include -

 Production Planning
 Indent of raw material and packaging material.
 Inventory monitoring to meet with marketing requirements

Raw Material Stores :: RM Stores has 100% controlled environment storage for
active and inactive raw materials. Dispensing of raw material as per prevailing
cGMP norms and SOPs.

    Facilities -

 Separate Areas like Receipt, Under Test and Approved raw materials.
 3 Separate Sampling Booths with Reverse Laminar Air Flow System.
 4 Dispensing Booths with Reverse Laminar Air Flow System.

Packing Material Store ::

 Separate area for Receipt/ Under test and Approved Materials

 All packaging materials are stored as per cGMP guidelines and procedures
laid down in SOPs.
 Maintaining controlled environment for primary packaging materials.
 Dispensing batch-wise as per SOPs.

Bonded Store Room (BSR) ::

 Formulations and API are kept in BSR in controlled environmental

conditions.
  Facilities are also available for cold chain products
 The finished products are dispatched from BSR to Duty Paid Store for
Domestic sales after compliance of Central Excise Duty formalities.
 Dispatches of finished goods to Cargo Handling Agents for Exports

Duty Paid Store (DP Store) ::

 Storage facility available for controlled condition and cold chain products.
 Country wide 22 C & F Agents catered by DP stores.
 Promotional inputs dispatches to concerned Marketing Field Force.

Active Pharmaceutical Ingredients Store (API Store) ::

 Activities similar to raw materials stores of formulation plant are undertaken

 Caters to the requirements of API manufacturing facilities.
 Handles bulk storage of various chemicals, solvents and hazardous materials
 Facility available to store the RMs in controlled environment
 Utmost care, safety precautions to maintain better working conditions.
 ERP IN TORRENT PHARMA

Pharma ERP
CCE Software has designed and developed GMP compliant Pharma ERP,
which is a comprehensive solution for Pharmaceutical Manufacturing. The ERP
solution complies with GAMP norms and 21 CFR Part 11 guidelines

Why Pharma ERP for your business?

Whether you need to increase your market share or be more profitable, Pharma
ERP solution can help you achieve your goals and bring significant return on
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enhanced effectiveness , improves the efficiency of the processes and streamline
internal operations.

Pharma ERP by CCE Software offers a gamut of modules that can be customized,
seamlessly integrated and implemented in modular form to suit your business
needs. CCE offers Pharma ERP with Complete Validation (IQ. OQ & PQ).
Pharma ERP Modules
Admin
Vendor approval process
Materials Management
Stores and Excise
Production Planning & Control
Maintenance Management
 
Warehousing
Audit trail
SOP document management
Quality
Sales, Distribution & Marketing
Finance
MIS
Tablet Facility ::

 Tablet facility: Modernized / Upgraded to Meet International

Standards.
 Department has following Hygiene Zones:
o 'O' Area - Products exposed to environment
o 'E' Area - Products in close containers
o Entry from 'E' to 'O' area is restricted by separate gowning
procedure.
 Area-wise personnel and material movement through separate air
lock.
 All manufacturing area has 100% fresh air to avoid cross
contamination.

Equipments ::

 Wet Granulation
 Dry Compaction / Granulation
 Pellet Coating
 Film Coating
 Enteric Coating
 Sugar Coating
 Bilayer Tablet

Equipments ::

MACHINE     TOTAL    CAPACITY

QTY     
Mechanical 6    100 Kg / Hr
Sifter   
Commniting 4 150 Kg / Hr
mill   
Drum Blender  1 100 Kg
Jacketed 2
Planetory Mixer 
Rapid Mixer & 1/1 450 Lit / 900 Lit
Granulators 
Roll Compactor  1 100 Kg / Hr
Fluid Bed Dryers  1/1 160 Kg. / 300
Kg.
Cage Blenders  1/1 160Kg. / 300 Kg
Turbo Sifters 2
Fluidized Bed 1 320 Lit
Processor (Glatt
Gmbh)
Lifting & 1/1 160 Kg. / 300
Positioning Kg
Device  
Tipplers  2 150 Kg / Hr
Compression 8 6.0 Million Tabs
Machines   / Shift
Coaters  1 300 Kg
4 160 Kg