Pamantasan ng Lungsod ng Maynila

Intramuros, Manila
College of Nursing

GROUP E1
Gatchalian, Rica Mae P. BSN 2-2

Drug Name Dosage, Mechanism of Action Indication(s) Contraindication(s) Side Effects Nursing
(Generic Frequency, Intervention
Name, Brand Route
Name, Stock
Dose)
Isoxsuprine, PO 10-20 mg, Description: Treatment of Preexisting Transient Monitor for
Duvadilan, 3-4 times/day Isoxsuprine, a β- premature hypotension, nausea, therapeutic
10-20 mg (Vasodilator) agonist, increases labor, cerebral prolonged premature vomiting, effectiveness:
Response to
muscle blood flow by & peripheral rupture of flushing,
treatment of
Initially 200- directly relaxing the vascular membranes, tachycardia, peripheral vascular
500 mcg/min vascular smooth disease. hemorrhage. rashes, GI disorders may take
IV infusion muscle. disturbances several weeks.
(Arresting Pharmacokinetics: & maternal
premature Absorption: Well pulmonary Evaluate clinical
labor) absorbed from the GI edema. manifestations of
arterial
tract. Time to peak
insufficiency.
plasma concentration:
Approx 1 hr. Monitor BP and
Distribution: Crosses pulse; may cause
the placenta. hypotension and
Excretion: Excreted tachycardia.
via urine as
conjugates. Plasma Supervise
elimination half-life: ambulation.
Approx 1.5 hr.
Observe both
mother and baby for
hypotension and
irregular and rapid
heartbeat if
isoxsuprine is used
to delay premature
labor.
Hypocalcemia,
hypoglycemia, and
ileus have been
observed in babies
born of mothers
taking isoxsuprine.