LAB VALUES!!!

Leukocyte Adhesion Deficiency C2 deficiency

Innate: Innate:
C3, C4 = normal C3, C4 = normal
CH50 = normal CH50 = undetectable
Oxidative Burst (DHR) = normal Oxidative Burst (DHR) = normal

Adaptive: Adaptive:
Quantitative Immunoglobulin levels: Quantitative Immunoglobulin levels:
 IgG = 1025 mg/dL (normal)  IgG = 955 mg/dL (normal)
 IgA = 95 mg/dL (normal)  IgA = 105 mg/dL (normal)
 IgM = 75 mg/dL (normal)  IgM = 75 mg/dL (normal)

Vaccine responses: Vaccine responses:
 Tetanus titer = 0.4 (Normal > 0.1),  Tetanus titer = 0.4 (Normal > 0.1),
 Diphtheria titer = 0.1 (Normal > 0.01),  Diphtheria titer = 0.1 (Normal > 0.01),
 Pneumococcal titers = Protective titers to 18 of the  Pneumococcal titers = Protective titers to 16 of the 24
24 serotypes serotypes

Lymphocyte subset analysis: Lymphocyte subset analysis:

 normal absolute numbers of T cells, B cells, and NK  normal absolute numbers of T cells, B cells, and NK
cells cells

T cell function: T cell function:

 Normal response to mitogens  Normal response to mitogens
 Wiscott Aldrich Syndrome Severe Combined Immunodeficiency
Innate: Innate:
C3, C4 = normal C3, C4 = normal
CH50 = normal CH50 = normal
Oxidative Burst (DHR) = normal Oxidative Burst (DHR) = Normal

Adaptive: Adaptive:
Quantitative Immunoglobulin levels: Quantitative Immunoglobulin levels:
 IgG 140 mg/dL (low)  IgG 30mg/dl (nml > 400mg/dl) (low)
 IgA 135 mg/dL (normal)  IgA 75 mg/dL (low normal)
 IgM 52 mg/dL (low normal)  IgM 145 mg/dL (low normal)
 IgE 1047 IU/mL (high)

Vaccine responses: Vaccine responses:

 Tetanus titer = 0.4 (Normal > 0.1),
 Diphtheria titer = 0.1 (Normal > 0.01),
 Pneumococcal titers = Protective titer to only 3 of
the 24 serotypes
Lymphocyte subset analysis:
 Normal absolute numbers B cells, and NK cells; T
cells low normal
T cell function:
 Response to Mitogen: T cells proliferate at only
about 30% the rate of T cells from a normal
individual tested at the same time.
 Tetanus titer = undetectable
 Diphtheria titer = undetectable
 Pneumococcal titers = undetectable
Lymphocyte subset analysis:
• Absolute WBC of 4800/µl (NR: 5000-10,000) and
absolute lymphocyte count was 760/µl (NR: ~ 3000)
• No T cells (neither CD4+ nor CD8+)
• B cells present
• Few NK cells
T cell function:
• No response to mitogen stimulation
 Chronic Granulomatous Disease Acquired Angioedema
Innate: Innate:
C3, C4 = normal C3, C4 = low
CH50 = normal CH50 = low to low normal
Oxidative Burst (DHR) = low Oxidative Burst (DHR) = normal

Adaptive: Adaptive:
Quantitative Immunoglobulin levels: Quantitative Immunoglobulin levels:
 IgG = 1825 mg/dL (high)  IgG - 1525 mg/dL (high)
 IgA = 95 mg/dL (normal)  IgA = 95 mg/dL (normal)
 IgM = 75 mg/dL (normal)  IgM = 75 mg/dL (normal)

Vaccine responses: Vaccine responses:

 Tetanus titer = 0.4 (Normal > 0.1),  Tetanus titer = 0.4 (Normal > 0.1),
 Diphtheria titer = 0.1 (Normal > 0.01),  Diphtheria titer = 0.1 (Normal > 0.01),
 Pneumococcal titers = Protective titers to 19 of the  Pneumococcal titers = Protective titers to 15 of the 24
24 serotypes serotypes

Lymphocyte subset analysis: Lymphocyte subset analysis:

 Normal absolute numbers of T cells, B cells, and NK  Normal absolute numbers of T cells, B cells, and NK
cells cells

T cell function: T cell function:

 Normal response to mitogens  Normal response to mitogens
 Medication-Induced Neutropenia

Innate:
C3, C4 = normal
CH50 = normal
Oxidative Burst (DHR) = normal

Adaptive:
Quantitative Immunoglobulin levels:
 IgG = 1525 mg/dL (high)
 IgA = 95 mg/dL (normal)
 IgM = 75 mg/dL (normal)

Vaccine responses:
 Tetanus titer = 0.4 (Normal > 0.1),
 Diphtheria titer = 0.1 (Normal > 0.01),
 Pneumococcal titers = Protective titers to 15 of the
24 serotypes

Lymphocyte subset analysis:

 Low absolute numbers of T cells, B cells, and NK
cells

T cell function:
Normal response to mitogens