Exercise 18 KAOLIN SUSPENSION

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1. Active ingredient or the Kaolin 12. In both preparations, kaolin is levigated lumping
suspensoid with glycerin in order to prevent _____ as
it is combined with
2. Aggregation of the settled Caking.
carboxymethylcellulose aqueous
dispersed particles forming a
solution.
hard cake that is hard to
redisperse. 13. Insoluble dispersed phase (solid) in a Suspensions
dispersion medium
3. Appearance of both products White liquid with dispersed
particles 14. Kaolin or? Native hydrated
aluminum
4. Appearance of sediment Preparation A: Closely
silicate
packed
Preparation B: Loosely 15. Label Shake well
packed. before use
5. Category Gastrointestinal Drug 16. Maximum concentration of flocculating Flocculated;
agent is reached to produce a _____ deflocculated
6. Container 15 mL clean amber or flint
system. Beyond that, it produces _______
(more pharmaceutically
system.
elegant) bottle
17. Official Title Kaolin
7. Degree of flocculation = ? Degree of flocculation =
Suspension
If equal to 1, ? Fflocculated/Fdeflocculated
(non-official)
= B = 1 = flocculated
18. Packaging Req't Store in a cool,
8. The dispersed particles are Floccules; Dispersed
dry place away
held together in loose particles; no; clear
from direct heat
aggregates called _____.
and light
______ lessen the elegance of
the preparation because of 19. The particle size of the suspensoid constant
their tendency to separate should remain fairly _____ during long
from the dispersion medium periods of standing.
but they avoid caking and are
20. Particle sizes of insoluble dispersed o.2 microns
easy to residers.
phase or solids in a suspension
Are aggregates noticed?
Appearance? 21. A pharmaceutical suspension should slowly; readily
settle _____ and should be _______
9. The dispersed particles are Deflocculated systems;
dispersed upon gentle shaking.
left as is. Dispersed particles cloudy
The suspension should pour out readily
give the preparation a
and easily as well.
uniform appearance as they
tend to settle less rapidly but 22. pH of both products 7.3
they can form a hard cake 23. Physical Stability No
upon settling and are hard to sedimentation,
redisperse. caking present
Many physical instability. and partially
Appealing. soluble internal
Aggregates lead to produce a phase
hard cake.
24. Pourability of both products Easily pourable
Appearance?
25. Preparations containing finely divided Suspensions
10. Dispersion medium Purified water
drug particles (the suspensoid) dispersed
11. Flocculating agent Monobasic potassium somewhat uniformly in a vehicle in which
phosphate the drug exhibits minimum solubility.
26. Preservative Sodium
benzoate
27. Redispersability of both products Easily redispersed upon shaking
28. Sedimentation rate = ? Sedimentation rate = V = [d*d (Ps - Pe) g]/ 18 n
29. Sedimentation rate is under the ____ Law. Stoke's
30. Sedimentation rate, sedimentation volume, degree of flocculation Preparation A: Slow, 0.15, 1
Preparation B: Fast, 0.75, 5
31. Settling of the dispersed phase. Sedimenation; Gentle shaking
How is this remedied in a stable preparation?
32. Suspending agent Carboxymetylcellulose
33. Synonyms Kaolin Mixture
34. Upon addition of the flocculating agent, it becomes _____. Loose
35. Uses Toxin absorbent; For treatment of diarrhoea,
chronic ulcerative colitis
36. Usually added to promote pharmaceutical elegance and dosage uniformity. Suspending agents; carboxymethylcellulose
(Para di agad magsettle o bumaba)
Example?
37. Volume of sedimentation = ? Volume of sedimentation = F = Vo/Vt =1
Ideal value = ? Ideal value = 1
38. Wetting agent Glycerin

What happens if its excess? if less? Excess leads to frothing, while less leads to
lumps formation.
39. What does non-official mean? Never naging official :(
40. What does unofficial mean? Once naging official

#WalangForever :(
41. What type of suspensions is Preparation A? Preparation B? Deflocculated; Flocculated;