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    POTTs Disease Patho

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    Edgel Quidoles
    This document discusses the pathophysiology of Pott's disease, which is spinal tuberculosis. There are both non-modifiable and modifiable risk factors. The disease causes gradual spinal cord compression that can lead to a fracture. As the tuberculosis bacilli kill disk tissue, it causes progressive microcellular damage. This triggers an immune response and increases blood flow, causing symptoms like fever and back pain. Ultimately, the spinal compression can result in paraparesis, urinary retention, constipation, and other issues due to decreased mobility and sensation in the lower extremities.

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    POTTs Disease Patho

    Uploaded by

    Edgel Quidoles
    86 views3 pages
    This document discusses the pathophysiology of Pott's disease, which is spinal tuberculosis. There are both non-modifiable and modifiable risk factors. The disease causes gradual spinal cord compression that can lead to a fracture. As the tuberculosis bacilli kill disk tissue, it causes progressive microcellular damage. This triggers an immune response and increases blood flow, causing symptoms like fever and back pain. Ultimately, the spinal compression can result in paraparesis, urinary retention, constipation, and other issues due to decreased mobility and sensation in the lower extremities.

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    This document discusses the pathophysiology of Pott's disease, which is spinal tuberculosis. There are both non-modifiable and modifiable risk factors. The disease causes gradual spinal cord compression that can lead to a fracture. As the tuberculosis bacilli kill disk tissue, it causes progressive microcellular damage. This triggers an immune response and increases blood flow, causing symptoms like fever and back pain. Ultimately, the spinal compression can result in paraparesis, urinary retention, constipation, and other issues due to decreased mobility and sensation in the lower extremities.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    86 views3 pages

    POTTs Disease Patho

    Uploaded by

    Edgel Quidoles
    This document discusses the pathophysiology of Pott's disease, which is spinal tuberculosis. There are both non-modifiable and modifiable risk factors. The disease causes gradual spinal cord compression that can lead to a fracture. As the tuberculosis bacilli kill disk tissue, it causes progressive microcellular damage. This triggers an immune response and increases blood flow, causing symptoms like fever and back pain. Ultimately, the spinal compression can result in paraparesis, urinary retention, constipation, and other issues due to decreased mobility and sensation in the lower extremities.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Download as docx, pdf, or txt
    of 3

    PATHOPHYSIOLOGY

    Non-modifiable factors: Modifiable factors:


    -Sex (1.5-2:1 male to female ratio) -Environmental hazard
    -Age (common in children and young adults) -Contact with an infected person
    -Family History

    Spinal cord compression (T3 and T5)

    Gradual onset of weakness on lower extremities

    Ataxic Gait (Drunken Gait) Consultation to BMC

    Complete loss of sensation on lower


    Progression of Compression to a Spinal Cord Fracture
    extremities

    Immunocompromised

    M. tuberculosis bacilli kill


    POTT’S DISEASE surrounding disk tissue

    Progressive microcellular damage


    / injured cells release of Disk tissue dies by
    chemicals (T9-T12) caseation of disk
    tissue
    Circulating B-lymphocytes
    stimulated producing Cytokine interleukin-2 (responsible Cytokine interleukin-1 & 6 Increase metabolic
    immunoglobulins (antibodies) for cell mediated response) vasoconstrictive agents function for body
    stimulate pyrogen release temperature w/ the
    Antibodies attach to the aid of the
    Binds to interleukin-2 receptor
    bacterial antigen tagging hypothalamic thermo
    site of TB specific lymphocytes
    them for phagocytosis regulating system
    Vasodilation of the
    T lymphocites activated involved blood vessels
    TB specific lymphocytes Increase blood flow Fever Increase the demand
    identify the bacterial antigen for glucose and other
    & will perform phagocytosis nutrients
    Redness Heat

    Fragments of the bacillus triggers Diagnostic Increase capillary permeability of the


    increase WBC production hematology WBC surrounding area allowing plasma to
    of 12,700mm3 leak from blood stream into the
    extravascular space
    Microbial Killing Leukocytosis Neutrophils: 87%

    Localize edema
    Rapid cell death Lymphocytopenia Lymphocytes
    (prolonged infection) 7% Pressure to the surrounding area
    Abscess
    Diagnostics show T8 Pain receptor activated
    Vertebral Abscess

    Back pain
    Diagnostic
    Vertebral narrowing Vertebral collapse (T9-T12) -MRI
    -CT scan
    Urinary retention
    Compression of the Kyphosis
    spinal cord Constipation

    Decreased ability to feel the urge and to


    Paraparesis control defecation and micturition
    Decreased Metabolism

    Weakness from lower Decreased muscle rating and sensory Decreased physical
    epigastric region downward Muscle atrophy
    perception at lower extremity activity

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