SIDE EFFECTS AND ADVERSE

DRUG MECHANISM OF ACTION INDICATION NURSING ACTION

EFFECTS
Inhibits DNA synthesis by Metastatic testicular and CNS: SEIZURES, malaise,  Monitor vital signs frequently
producing cross-linking of ovarian carcinoma. Advanced weakness. 
during administration. Report
EENT: ototoxicity, tinnitus.
parent DNA strands (cell-cycle bladder cancer. Head and
GENERIC NAME:
 GI: severe nausea, vomiting, significant changes
cisplatin phase—nonspecific).  neck cancer. Cervical cancer. diarrhea, hepatotoxicity. 
Therapeutic Effects: Death of Lung cancer. Other tumors. GU: nephrotoxicity, sterility.   Monitor intake and output and
Derm: alopecia. 
rapidly replicating cells, specific gravity frequently
BRAND NAME:
F and E: hypocalcemia,
Platinol particularly malignant ones. during therapy.
hypokalemia, hypomagnesemia.
 Hemat: LEUKOPENIA,
THROMBOCYTOPENIA, anemia.
 Report discrepancies
DRUG CLASSIFICATION:
 Local: phlebitis at IV site.  immediately.
Antineoplastics Metab: hyperuricemia. 
Neuro: peripheral neuropathy.  Encourage patient to drink
 Misc: anaphylactoid reactions.
2000– 3000 mL/day to
CONTRAINDICATION INTERACTIONS
Hypersensitivity; Orally disintegrating Drug-Drug: risk of nephrotoxicity and promote excretion of uric acid.

tablets contain aspartame and ototoxicity with other nephrotoxic and

 Assess patency of IV site
should not be used in patients with ototoxic drugs (aminoglycosides,
phenylketonuria; loop diuretics).risk of hypokalemia frequently during therapy.

and hypomagnesemia with loop

 Monitor amount of emesis
diuretics and amphotericin B.

Maypphenytoin levels. bone marrow and notify health care

depression with other antineoplastics professional if emesis

or radiation therapy. May antibody exceeds guidelines to prevent

response to live-virus vaccines and dehydration.

adverse reactions
 Monitor for bone marrow

depression.

 Assess for bleeding

 Monitor for increased fatigue,

dyspnea, and orthostatic

hypotension.

 Monitor for signs of

 anaphylaxis

 Assess patient frequently for

dizziness, tinnitus, hearing

loss, loss of coordination, loss

of taste, or numbness and

tingling of extremities