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Aarav Singh March 2018 PDF
Aarav Singh March 2018 PDF
PatientReportSCSuperPanel.GENERAL_PANEL_ANALYTE_SC (Version: 6)
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| Multiple (2+) Risk | < 130 | < 160 |
| Factors and 10 year | | |
| risk < or = 20% | | |
|----------------------|-------------------------|----------------------|
| 0-1 Risk factor | < 160 | <190 |
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Comment:
ATP III suggested the addition of Non HDL Cholesterol (Total Cholesterol - HDL Cholesterol) as an indicator of
all atherogenic lipoproteins ( Mainly LDL & VLDL). The Non HDL Cholesterol is used as a secondary target of
therapy in persons with triglycerides >=200 mg/dL. The goal for Non HDL Cholesterol in those with increased
triglyceride is 30 mg/dL above that set for LDL Cholesterol.
For calculation of CHD risk, history of smoking, any medication for hypertension & current blood pressure
levels are required.
PatientReportSCSuperPanel.GENERAL_PANEL_ANALYTE_SC (Version: 6)
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PatientReportSCSuperPanel.GENERAL_PANEL_ANALYTE_SC (Version: 6)
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Lymphocytes 49.20 %
Monocytes 8.00 %
Eosinophils 3.60 %
Basophils 0.80 %
Absolute Leucocyte Count
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Physical
Chemical
Microscopy
PatientReportSCSuperPanel.URINE_EXAMINATION_SC (Version: 6)
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Interpretation
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| As per American Diabetes Association (ADA) |
|-------------------------------------------------------------------------------|
| Reference Group | HbA1c in % |
|-------------------------------|-----------------------------------------------|
| Non diabetic adults >=18 years| <5.7 |
|-------------------------------|-----------------------------------------------|
| At risk (Prediabetes) | 5.7 - 6.4 |
|-------------------------------|-----------------------------------------------|
| Diagnosing Diabetes | >= 6.5 |
|-------------------------------|-----------------------------------------------|
| Therapeutic goals for glycemic| Age > 19 years |
| control | . Goal of therapy: < 7.0 |
| | . Action suggested: > 8.0 |
| | |
| | Age < 19 years |
| | . Goal of therapy: <7.5 |
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Note: 1. Since HbA1c reflects long term fluctuations in the blood glucose concentration, a
diabetic patient who is recently under good control may still have a high concentration of
HbA1c. Converse is true for a diabetic previously under good control but now poorly
controlled .
2. Target goals of < 7.0 % may be beneficial in patients with short duration of diabetes, long
life expectancy and no significant cardiovascular disease. In patients with significant
complications of diabetes, limited life expectancy or extensive co-morbid conditions,
targeting a goal of < 7.0 % may not be appropriate.
Comments
HbA1c provides an index of average blood glucose levels over the past 8 - 12 weeks and is a much better
indicator of long term glycemic control as compared to blood and urinary glucose determinations.
ADA criteria for correlation between HbA1c & Mean plasma glucose levels
---------------------------------------
| HbA1c(%) | Mean Plasma Glucose (mg/dL)|
|----------|----------------------------|
| 6 | 126 |
|----------|----------------------------|
| 7 | 154 |
|----------|----------------------------|
| 8 | 183 |
|----------|----------------------------|
PatientReportSCSuperPanel.HBELECTRO_SC (Version: 7)
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PatientReportSCSuperPanel.HBELECTRO_SC (Version: 7)
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Clinical Utility
· Evaluation of fasting hypoglycemia
· Evaluation of Polycystic Ovary syndrome
· Classification of Diabetes mellitus
· Predict Diabetes mellitus
· Assessment of Beta cell activity
· Select optimal therapy for Diabetes
· Investigation of insulin resistance
· Predict the development of Coronary Artery Disease
Increased levels - Insulinoma, Some Type II diabetic patients, Infantile hypoglycemia, Hyperinsulinism,
Obesity, Cushing's syndrome, Oral contraceptives, Acromegaly, Hyperthyroidism
PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)
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Comments
This test is used for the determination of IgA autoantibodies to human tissue transglutaminase for the
differential diagnosis of Celiac disease / Gluten sensitive enteropathy (GSE). Celiac disease is characterized
by small intestinal damages with flat mucosa leading to malabsorption with depletion of key nutrients. Tissue
transglutaminase is one of the main endomysial autoantigens that can be easily detected for the diagnosis of
Celiac disease. Other recommended tests are Endomysial, Gliadin & Reticulin antibodies along with small
intestinal biopsy. Negative serology does not exclude a diagnosis of GSE. IgA deficiency should be
considered in patients with suggestive clinical presentation.
Note
PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)
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Comments
Vitamin D promotes absorption of calcium and phosphorus and mineralization of bones and teeth. Deficiency
in children causes Rickets and in adults leads to Osteomalacia. It can also lead to Hypocalcemia and
Tetany. Vitamin D status is best determined by measurement of 25 hydroxy vitamin D, as it is the major
circulating form and has longer half life (2-3 weeks) than 1,25 Dihydroxy vitamin D (5-8 hrs).
Decreased Levels
· Inadequate exposure to sunlight
· Dietary deficiency
· Vitamin D malabsorption
· Severe Hepatocellular disease
· Drugs like Anticonvulsants
· Nephrotic syndrome
Increased levels
Vitamin D intoxication
Titer 1:10
Note
1. Autoimmune reactivities are not by themselves diagnostic, but must be correlated with other laboratory
& clinical findings
2. A useful test for exclusion of Celiac disease is HLA - DNA testing for the presence of DQ 2 (DQB1*02,
PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)
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Comments
IgA class of Endomysial antibodies are present in nearly 100% patients of Celiac disease. Thus their
identification is considered diagnostically sensitive and specific for Gluten sensitive enteropathies. Positivity is
also seen in some cases of Dermatitis herpetiformis.
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| DISEASE | PERCENT POSITIVITY |
|--------------------------------|------------------------|
| Confirmed Celiac disease | |
| On Gluten | 100 |
| On Gluten free diet | 46 |
|--------------------------------|------------------------|
| Suspected Celiac disease | |
| On Gluten | 90 |
| On Gluten free diet | 17 |
|--------------------------------|------------------------|
| Dermatitis herpetiformis | 80 |
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Dr. Ritu Nayar Dr. Shalabh Malik Dr. Anil Arora Dr Biswadip Hazarika
MD (Microbiology) MD (Microbiology) MD (Pathology) MD (Pathology)
Deputy HOD Microbiology & Serology - National Head - Microbiology & HOD Hemat & Imm - NRL Sr. Consultant Pathologist - NRL
NRL Serology - NRL
PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)
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