Drug Indication Contraindication Special Precaution Drug Interaction Mechanism of Action Adverse Reaction

Epinephrine  Acute Asthma

Preexisting CV diseases; Halogenated Epinephrine, an active NS effects; GI
 Advanced Cardiac
Life Support hypertension; hyperthyroidism; inhalation principle of the adrenal disturbances;
 Anaphylactic occlusive vascular DM; Parkinson's anaesthetics; β- or medulla, is a direct- epigastric pain; CV
Shock disease; angle- disease; elderly; α-blocking agents; acting disorders; difficulty
 Open Angle closure glaucoma pregnancy, lactation. methyldopa, guan sympathomimetic. It in micturition with
Glaucoma
(eye drops); ethidine; drugs stimulates α- and β- urinary retention;
hypersensitivity; with adrenergic receptors dyspnoea;
cardiac vasoconstrictor resulting in relaxation of hyperglycaemia;
arrhythmias or and pressor smooth muscle of the sweating;
tachycardia. When effects; bronchial tree, cardiac hypersalivation;
used in addition to antihypertensives; stimulation and dilation weakness, tremors;
local anaesthetics: adrenergic neuron of skeletal muscle coldness of
Procedures blockers; vasculature. It is extremities;
involving digits, potassium- frequently added to hypokalaemia.
ears, nose, penis depleting drugs; local anaesthetics to Gangrene, tissue
or scrotum. cardiac glycosides; retard diffusion and necrosis and
ephedra, limit absorption, to sloughing
yohimbe. TCAs prolong the duration of (extravasation)
may induce effect and to lessen the when used in
hypertension and danger of toxicity. addition to local
arrhythmia. anaesthetics. Eye
drops: Severe
smarting, blurred
vision,
photophobia; naso-
lachrymal ducts
obstruction.
Oedema,
hyperaemia and
inflammation of the
eyes with repeated
administration.