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  • Flow Chart Neozep F Exp Tablet

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    Rio Febriansyah
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    This document outlines the process flow for manufacturing NeoZep F tablets before and after improvement. It shows the steps of spray drying, comminution, binder preparation, and dry mixing for both the white and green layers. The key changes after improvement were increased monthly size and batch size, along with adjustments to ingredients and process parameters.

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    This document outlines the process flow for manufacturing NeoZep F tablets before and after improvement. It shows the steps of spray drying, comminution, binder preparation, and dry mixing for both the white and green layers. The key changes after improvement were increased monthly size and batch size, along with adjustments to ingredients and process parameters.

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    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
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    Download as doc, pdf, or txt
    72 views4 pages

    Flow Chart Neozep F Exp Tablet

    Uploaded by

    Rio Febriansyah
    This document outlines the process flow for manufacturing NeoZep F tablets before and after improvement. It shows the steps of spray drying, comminution, binder preparation, and dry mixing for both the white and green layers. The key changes after improvement were increased monthly size and batch size, along with adjustments to ingredients and process parameters.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    of 4

    PROCESS FLOW CHART

    NEOZEP F TABLET ( EXPORT ) / WHITE LAYER


    BEFORE IMPROVEMENT
    Mo Size : 1.000.000 Tabs
    Batch Size : 1.000.000 Tabs
    Acetaminophen 285 kg SPRAY & DRYING
    Corn Starch 41.7 kg

    Comminute :
    Phenylephrine HCl 5.7 kg Ss round hole screen
    Corn Starch ( 8 scopps ) #1532-0040, med speed, FINAL DRYING
    kf forward
    Outlet air temp : 38 - 41C

    Preparation of
    BinderSolution
    Corn starch 2x 6.305 kg
    Povidone 2x 7.41 kg
    Disperse & stir well
    until homogeneous
    CTM 2x 0.57 kg
    20-gal SS Cont Glatt WSG 200,V,VI,VII,VIII

    COMMINUTION

    Fitzpatrick comminution machine


    SS Round hole Screen #1531-0065,
    Low Speed, Impact forward

    DRY MIXING
    Dried Granules 361 kg

    Sodium Starch Glycolat Pass through ss wire Mix for 17 minutes


    7.42 kg
    mesh screen # 1536-0020
    Magnesium Stearat
    1.856 kg
    Dried Granules ( 4 scoops ) CF BLENDER / GEMCO
    BLENDER
    PROCESS FLOW CHART
    NEOZEP F TABLET ( EXPORT ) / GREEN LAYER
    BEFORE IMPROVEMENT
    Mo Size : 1.000.000 Tabs
    Batch Size : 1.000.000 Tabs

    Acetaminophen 215 kg PARTIAL SPRAY & DRYING


    Corn Starch 31.44 kg

    Comminute :
    Phenylephrine HCl 4.3 kg Ss round hole screen
    Corn Starch ( 8 scoops ) #1532-0040, med speed,
    Outlet air temp : 48C
    kf forward

    Preparation of
    Corn starch 4.756 kg BinderSolution
    Povidone 5.592 kg Disperse & stir well
    CTM 0.43 kg until homogeneous
    Glatt WSG 200,V,VI,VII,VIII
    D&C Yell 10, 54.18 g
    FD&C Blue no 1 0.163 kg 20-gal SS Cont

    PARTIAL COMMINUTION

    Fitzpatrick comminution machine


    SS Round hole Screen #1532-0033,
    High Speed, Impact forward

    FINALSPRAY & DRYING


    Corn starch 4.756 kg Preparation of
    Povidone 5.592 k BinderSolution
    CTM 0.43 kg
    Disperse & stir well
    D&C Yell 10, 54.18 g until homogeneous Outlet air temp : 36C
    FD&C Blue no 1 0.163 kg
    20-gal SS Cont

    Glatt WSG 200,V,VI,VII,VIII

    FINAL COMMINUTION

    Fitzpatrick comminution machine


    SS Round hole Screen #1531-0065,
    Low Speed, Impact forward

    DRY MIXING
    Dried Granules 272.7 kg

    Sodium Starch Glycolat Pass through ss wire Mix for 17 minutes


    5.596 kg
    mesh screen # 1536-0020
    Magnesium Stearat
    1.403 kg
    Dried Granules ( 4 scoops ) CF BLENDER / GEMCO
    BLENDER
    PROCESS FLOW CHART
    NEOZEP F TABLET ( EXPORT ) / WHITE LAYER
    AFTER IMPROVEMENT
    Mo Size : 1.100.000 Tabs
    Batch Size : 1.100.000 Tabs
    Acetaminophen 313.5 kg SPRAY & DRYING
    Corn Starch 45.87 kg

    Phenylephrine Hcl 6.27 kg Comminute :


    Ss round hole screen
    Corn Starch ( 8 scop ) #1532-0040, med speed, FINAL DRYING
    kf forward Outlet air temp : 38 - 41C

    Preparation of
    BinderSolution
    Corn starch 2x 6.936 kg
    Povidone 2x 8.151 kg
    Disperse & stir well
    until homogeneous
    CTM 2x 0.627 kg
    20-gal SS Cont Glatt WSG 200,V,VI,VII,VIII

    COMMINUTION

    Fitzpatrick comminution machine


    SS Round hole Screen #1531-0065,
    Low Speed, Impact forward

    DRY MIXING
    Dried Granules 397.1 kg

    Sodium Starch Glycolat Pass through ss wire Mix for 17 minutes


    8.162 kg
    mesh screen # 1536-0020
    Magnesium Stearat
    2.042 kg
    Dried Granules ( 4 scoops ) CF BLENDER / GEMCO
    BLENDER
    PROCESS FLOW CHART
    NEOZEP F TABLET ( EXPORT ) / GREEN LAYER
    AFTER IMPROVEMENT
    Mo Size : 1.100.000 Tabs
    Batch Size : 1.100.000 Tabs

    Acetaminophen 236.5 kg PARTIAL SPRAY & DRYING


    Corn Starch 34.584 kg

    Comminute :
    Phenylephrine Hcl 4.73 kg Ss round hole screen
    Corn Starch ( 8 scop ) #1532-0040, med speed,
    Outlet air temp : 48C
    kf forward

    Preparation of
    BinderSolution

    Disperse & stir well


    Corn starch 5.232 kg until homogeneous
    Povidone 6.151 kg Glatt WSG 200,V,VI,VII,VIII
    CTM 0.473 kg 20-gal SS Cont
    D&C Yell 10, 59.598 g
    FD&C Blue no 1 0.179 kg

    PARTIAL COMMINUTION

    Fitzpatrick comminution machine


    SS Round hole Screen #1532-0033,
    High Speed, Impact forward

    FINALSPRAY & DRYING


    Corn starch 5.232 kg Preparation of
    Povidone 6.151 k BinderSolution
    CTM 0.473 kg
    Disperse & stir well
    D&C Yell 10, 59.598 g until homogeneous Outlet air temp : 36C
    FD&C Blue no 1 0.179 kg
    20-gal SS Cont

    Glatt WSG 200,V,VI,VII,VIII

    FINAL COMMINUTION

    Fitzpatrick comminution machine


    SS Round hole Screen #1531-0065,
    Low Speed, Impact forward

    DRY MIXING
    Dried Granules 299.97 kg

    Sodium Starch Glycolat Pass through ss wire


    6.156 kg Mix for 17 minutes
    mesh screen # 1536-0020
    Magnesium Stearat
    1.543 kg
    Dried Granules ( 4 scoops )
    CF BLENDER / GEMCO
    BLENDER

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