16/3/2018 Protein C levels as a prognostic indicator of outcome in sep...

: Critical Care Medicine

Protein C levels as a prognostic indicator of

outcome in sepsis and related diseases
Fisher, Charles J. Jr MD, FCCM; Yan, S. Betty PhD

Critical Care Medicine: September 2000 - Volume 28 - Issue 9 - p S49-S56

Scientific Reviews

Abstract Author Information

Objective To consider the appropriateness of protein C levels as a prognostic indicator for sepsis and related
diseases.

Data Sources/Study Selection Published research and review articles related to protein C deficiency in patients with
sepsis and related diseases.

Data Extraction and Synthesis All applicable data were extracted, and relevant literature was cited to support factual
statements in the text. The protein C pathway represents one of the major regulatory systems of hemostasis,
exhibiting antithrombotic, profibrinolytic, and anti-inflammatory properties. Numerous studies have shown that
acquired protein C deficiency is prevalent in the majority of septic patients (>85%) and is associated with increased
morbidity and mortality in patients with severe sepsis and septic shock. This deficiency in protein C is not simply a
transient marker for sepsis, but parallels the progress of the disease. In addition, protein C deficiency occurs in the
presence of a wide range of pathogens and develops early in the disease process.

Conclusions A review of the relevant literature suggests that protein C levels may serve as a useful prognostic
indicator of outcome in sepsis and related diseases.

From Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN.

Address requests for reprints to: Charles J. Fisher Jr, MD, FCCM, Eli Lilly and Company, DC6045, 307 East
McCarty Street, Indianapolis, IN 46285. E-mail: Fisher_Charles_J@Lilly.com

Presented, in part, at the Margaux Conference on Critical Illness, Margaux, France, November 11–13, 1999.

© 2000 Lippincott Williams & Wilkins, Inc.

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