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  • Farkin

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    Nisfatul L. Saidah
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    This document discusses pharmacokinetic calculations to determine the rate of infusion needed to achieve a steady state concentration of a drug. It is given that the half-life is 3.01 hours, clearance is 2.31 L/hour, and the desired steady state concentration is 8 mg/L. Using these values, the new rate of infusion calculated is 18.48 mg/hour.

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    This document discusses pharmacokinetic calculations to determine the rate of infusion needed to achieve a steady state concentration of a drug. It is given that the half-life is 3.01 hours, clearance is 2.31 L/hour, and the desired steady state concentration is 8 mg/L. Using these values, the new rate of infusion calculated is 18.48 mg/hour.

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    10 views1 page

    Farkin

    Uploaded by

    Nisfatul L. Saidah
    This document discusses pharmacokinetic calculations to determine the rate of infusion needed to achieve a steady state concentration of a drug. It is given that the half-life is 3.01 hours, clearance is 2.31 L/hour, and the desired steady state concentration is 8 mg/L. Using these values, the new rate of infusion calculated is 18.48 mg/hour.

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    © All Rights Reserved
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    of 1

    Diketahui:

     T = 8 jam
     Cp = 5,5 mg/L
     Css = 6,5 mg/L
     R = 15 mg/jam

    Jawab:
    - Mencari t1/2
    – 2,303 Css – Cp
    K = [ T
    ] log ( Css
    )
    – 2,303 6,5 – 5,5
    = [ 8
    ¿ log (
    6,5
    )

    = 0,23/jam
    0,693
    t1/2 = 0,23

    = 3,01 jam

    - Mencari Cl
    R
    Css =
    Cl
    R
    Cl =
    Css
    15 mg/ jam
    =
    6,5 mg/ L
    = 2,31 L/jam

    - Mencari Laju Infus Baru


    Diket : Css = 8 mg/L
    R = Css x Cl
    = 8 mg/ L x 2,31 L/jam
    = 18,48 mg/jam

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