Drug Designing Training

Drug Designing Training

NTHRYS provides Drug Designing Training for interested candidates at its Hyderabad
facility, Telangana. Please refer below for more details including Fee strctures, Eligibility,
Protocols and Modules etc.,. Please do call / message / whatsapp for more details on
9014935156 [India - +91]

Protocols / Techniques Covered

Module - I - Molecular Modeling

1. Homology Modeling
2. Threading and fold recognition
3. Ab-initio prediction
1. Homology Modeling
1. Template detection (Tools: BLAST,FASTA,PDB-Blast)
2. Target –Template Alignment (Clustalw, Smith-Waterman)
3. Backbone generation
4. Modeling of side chains and loops (Modeller, CPH-Modeller, Swiss-
Model)
5. Model validation and optimization (WHATCHECK,VERIFY-3D,
ERRAT)
2. Threading of Fold Recognition:
1. 2D Threading [Tools: CASP, Gene Threader, 3DPSSM]
2. 3D Threading
3. Ab-initio prediction - Theory

Module - II - Drug Designing

1. Structure Based Drug Design (SBDD)

2. Ligand Based Drug Design (LBDD)

1. Structure Based Drug Design

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1. Collection of Structure
1. Known structure (PDB)
2. Unknown Structure (Homology Modeling)
2. Structure Validation
1. Profiles 3D
2. Ramachandran Plot
3. Disorder Analysis
3. Defining Binding sites
4. Small molecules search from databases (ZINC, TCM, Drug
bank,KEGG,PubChem)
5. ADMET Check
6. Docking
1. Candidates from docking result
2. Candidate from bioactivity prediction
7. Protein – Ligand complex formation
8. Molecular Dynamic simulation (MD simulation)
9. Thermodynamics Study:
1. state of system
2. changing state of system
3. Conversation of energy
4. Applied first law
5. study flow energy equation
10. Molecular Mechanics
1. Derivatives of molecular mechanics energy function
11. Force field calculation:
1. Bond angle
2. Bond Bending
3. Bond stretching
4. Angle bending
5. Torsion terms
6. Non-bonded interactions
7. Electrostatic interactions
8. Modeling Van der Waals interactions
9. Hydrogen bonding in molecular mechanics
10. Monte Carlo simulations (Algorithm)
12. Energy minimization & Optimization:
1. Root Mean Square Deviation calculation (RMSD)
2. Radius of Gyration
3. Root Mean Square Function Calculation
4. Dictionary of protein secondary structure analysis
5. Energy calculation of system
6. Mean square displacement
7. Distance analysis of molecular interactions
8. Torsion angle calculation
9. Principle component analysis
10. Estimation of molecular pathways

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Drug Designing Training

11. Disorder analysis

12. Clustering analysis
13. Potential Lead compound

Module - III

1. Ligand Based Drug Design

1. Small molecule with bioactivity
1. Docking
1. Evaluating Co-relation
2. Obtained Co-efficients
3. Weighted score models
2. Molecular properties check
3. Descriptors selection by genetic algorithm
1. Multiple linear regression models
2. Support vector machine (SVM)
3. Bayesian Networks Models
4. QSAR(Quantitative Structure Activity Relationship)
1. Comparative molecular field analysis (COMFA)
2. Comparative molecular similarity index analysis
(COMSIA)
3. 3D QSAR Pharmacophor model
2. Bioactivity prediction
3. Protein –Ligand complex
4. Molecular Dynamic Simulation,energy minimization and
optimization
1. Root mean square deviation (RMSD)
2. Radius of Gyration
3. Root Mean Square Function Calculation
4. Dictionary of protein secondary structure analysis
5. Energy calculation of system
6. Mean square displacement
7. Distance analysis of molecular interactions
8. Torsion angle calculation
9. Principle component analysis
10. Estimation of molecular pathways
11. Disorder analysis
12. Clustering analysis
5. Potential Lead compound
5 Days - Module - I, 6 Hours Work a day
10 Days - Module - I + Docking, 6 Hours Work a day
20 Days - Module - I & II, 4 Hours work a day
1 Month - Module - I,II & 1.1 of Module III, 4 Hours work a day
45 Days - Modules - I, II & III, 4 Hours work a day
Note: International Institution Students [Even Indian Nationals studying or studied

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at abroad] will be charged 20% extra to the fee given below.

Note:***

Other Trainings under this field >> Drug Designing Industrial Training, Drug Designing
Course Finishers Training, Drug Designing Job Oriented Training, & Drug Designing
Research Training

Fee Structures for Drug Designing Training

Fee details in Rs per student

Fee 5 Days 10 Days 20 days 1 Month 45 Days

Individual 19700 20700 21800 22800 25500

Group 2 - 4 18600 19700 20700 21800 24300
Group 5 - 7 18400 19500 20500 21600 24100
Group 8 - 10 18200 19300 20300 21300 23900

NTHRYS Biotech Labs | support@nthrys.com | 9014935156 | www.nthrys.com

A Govt. Registered Research Company
Drug Designing Training

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A Govt. Registered Research Company
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NTHRYS REGISTRATION PROCESS

1. Candidates have to pay Rs 5000/- in the below mentioned account to complete

Registration Process for selected services.
2. Registration fee is NOT ADDITIONAL AMOUNT we will reduce this from the
main fee at the time of joining.
3. After completing the fee payment, please scan the payment receipt as well as your
college identity card [ Any identity card for student proof] and email it to
support@nthrys.com of whatsapp the same to the below given number
4. After receiving this email NTHRYS staff will send you a Registration No, Fee
receipt & a Final Confirmation document to confirm the registration. For any
additional queries regarding registration process please call / sms / whatsapp on
+91 - 9014935156.

NTHRYS Account Information

Account Name: NTHRYS BIOTECH LABS
Account No: 400800301000092
Bank Name: Vijaya Bank
West Marredpalli Branch - Secunderabad, Andhra Pradesh, India
Branch Under RTGS: Yes
Branch Under NEFT: Yes
RTGS - IFSC Code: VIJB0004008

IMP NOTE:

1. Registration Fee is included in the total service fee and it is a Non Refundable Fee
as its charged to confirm the selected service slot as well as for issuing Service
Confirmation Document.
2. Total Service Fee = Registration Fee + Service Fee
3. Once the Service Confirmation document is issued, Students / Scholars / Clients are
requested to be in touch with assigned branches.
4. Balance fee must be paid at assigned branches to start the selected services.

NTHRYS Refund Policy of Selected Service Fees

1. Registration Fee is Non Refundable as its charged to confirm the selected service
slot as well as for issuing Legitimate Service Confirmation Document which are
used by Students / Scholars / Clients to submit in respective departments.
2. If the Assigned branch fail to conduct all the practicals / services / modules in
stipulated time period as per mentioned in the Selected Service Module, Students /
Scholars / Clients can request for refund only after getting a signed copy of Fee

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A Govt. Registered Research Company
Drug Designing Training

Refund confirmation document from the Branch Head stating the same.
3. Fee refund will be calculated by excluding the Registration fee from the Total Paid
Fees (Registration fee + Service fee paid at the time of joining) and the balance
practicals / protocols / modules from the Selected Service Module will only be
taken into account.
4. Students / Scholars / Clients who seek refund should email the above mentioned
Branch Head signed copy of Fee Refund confirmation document to legal [ a t ]
nthrys [ d o t ] com inorder to initiate the refund process. NTHRYS Legal Team
will synchronize with the Branch and initiate the refund with in 7 working days.
Emails sent to any other email id are not considered by our team for refund
requests.

NTHRYS Biotech Labs | support@nthrys.com | 9014935156 | www.nthrys.com

A Govt. Registered Research Company