Professional Documents
Culture Documents
Hallucinogens
Hallucinogens
Hallucinogens
LSD
- Found it from a fungus
- Flashbacks: gets absorbed in fat deposited in the body, and the fat deposited will
release it days or weeks later so that is what flashbacks are
o Concern because it is uncontrollable
o And builds up tolerance quickly and cross tolerance
- No documented overdoses
- It was assumed a long time ago that hallucinogens that are only serotonin, but now
know that dopamine and glutamate are involved
Seeman
- Understand that there are 2 diff hypothesis of psychosis and schizophrenia:
hyperdopmaine and hypoglutamate
- So what is dopamine’s contribution to PCP, LSD and ketamine
- All drugs work through the same mechanism and work on the dopamine system
- Paper basically says that Lieberman wrong
Lodge
- Ketamine and phencyclidine
o Discovered that ketamine was the world’s best antidepressant because SSRIs
take too long like 2-3 weeks to work
o Ketamine is a fast-acting antidepressant
o Talked about glutaminergic mechanisms