11/30/2019 Suggestive and atypical features of MS - UpToDate

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Suggestive and atypical features of multiple sclerosis

Features suggestive of multiple sclerosis

Relapses and remissions

Onset between ages 15 and 50 years

Optic neuritis

Lhermitte sign

Internuclear ophthalmoplegia

Fatigue

Heat sensitivity (Uhthoff phenomenon)

Features atypical for multiple sclerosis

Steady progression

Onset before age 10 or after age 50 years

Cortical deficits such as aphasia, apraxia, alexia, or neglect

Rigidity or sustained dystonia

Convulsions

Early dementia

Deficit developing within minutes

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