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    Acyclovir 2

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    lydia
    The document is calculating the buffer capacity of a 10 mL solution containing acyclovir at 25% concentration and a pH of 7.4. It determines the concentrations of KH2PO4 and Na2HPO4 needed to achieve this buffer capacity are 0.0094 g and 0.0142 g, respectively. The calculations involve determining the acid and conjugate base concentrations using the Henderson-Hasselbalch equation and then calculating the masses of each buffer component needed based on their molar masses and solution volume.

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    Acyclovir 2

    Uploaded by

    lydia
    10 views2 pages
    The document is calculating the buffer capacity of a 10 mL solution containing acyclovir at 25% concentration and a pH of 7.4. It determines the concentrations of KH2PO4 and Na2HPO4 needed to achieve this buffer capacity are 0.0094 g and 0.0142 g, respectively. The calculations involve determining the acid and conjugate base concentrations using the Henderson-Hasselbalch equation and then calculating the masses of each buffer component needed based on their molar masses and solution volume.

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    The document is calculating the buffer capacity of a 10 mL solution containing acyclovir at 25% concentration and a pH of 7.4. It determines the concentrations of KH2PO4 and Na2HPO4 needed to achieve this buffer capacity are 0.0094 g and 0.0142 g, respectively. The calculations involve determining the acid and conjugate base concentrations using the Henderson-Hasselbalch equation and then calculating the masses of each buffer component needed based on their molar masses and solution volume.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Download as docx, pdf, or txt
    10 views2 pages

    Acyclovir 2

    Uploaded by

    lydia
    The document is calculating the buffer capacity of a 10 mL solution containing acyclovir at 25% concentration and a pH of 7.4. It determines the concentrations of KH2PO4 and Na2HPO4 needed to achieve this buffer capacity are 0.0094 g and 0.0142 g, respectively. The calculations involve determining the acid and conjugate base concentrations using the Henderson-Hasselbalch equation and then calculating the masses of each buffer component needed based on their molar masses and solution volume.

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    of 2

    Lydia Nade Claudia Tandawuya

    18.01.295
    Transfer A 2018

    Dik : injeksi acyclovir 25% dalam 10 mL.


    pH = 7.4
    Kapasitas dapar = 0.01

    Dit: tentukan dapar dan konsentrasi masing-masing komponennya?

    Peny:
    Perhitungan Dapar Fosfat
    [H3O+] = 10-7,4
    pKa = 7,21
    ka = 6,3 x 10-8
    β¿ 2,303 x C x ka ¿ ¿
    6,3 x 10−8 x 10−7,4
    0,01¿ 2,303 x C x
    [6,3 x 10−8 x 10−7,4 ]2
    0,27064
    0,01¿ 2,303 x C x 303 x C x 0,27064/1,05678
    1,05678
    0,01¿ 2,303 x C x 0,2561303 x C
    0,01
    C¿
    2,303 x 0,2561
    C ¿ 0,01695 M

    [ garam]
    pH = pKa + log
    [asam]
    [ garam]
    7,4 = 7,21 + log
    [asam]
    [ garam]
    0,19 = log
    [asam]
    [ garam]
    1,5488 =
    [asam]
    [garam] = 1,5488 [asam]
    [asam] + [garam} = 0,01695
    2,5488 [asam] = 0,01695

    [0,01695]
    [asam] =
    [2,5488]
    = 0,0066 mol/L
    [garam] = 1,5488 [asam]
    = 1,5488 [0,0066]
    = 0,0102 mol/L
    = 0,0066 mol/L

    BM KH2PO4 = 141,96
    mol
    M=
    L
    g 1000 g
    M= x
    Mr V Mr
    m x Mr x V
    g=
    1000
    0,0066 x 141,96 x 10
    g=
    1000
    g = 0,0094 gram

    BM Na2HPO4 = 139,09
    m x Mr x V
    g=
    1000
    0,0102 x 139,09 x 10
    g=
    1000
    g = 0,014187 gram
    g = 0,0142 gra m

    jadi dapar yang digunakan adalah KH 2PO4 0,0094 g dan Na2HPO4 0,0142 g

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