Definition

Surgery is the standard treatment for patients with primary thyroid carcinoma, followed by
radioactive iodine therapy and/or thyroid hormone therapy. However, the risk of
complications increases in patients with a high-surgical risk [1]. In these patients, ultrasound
(US)-guided ablation techniques, including radiofrequency ablation (RFA) [2–5], laser ablation
(LA) [6–8] and microwave ablation (MWA) [9,10], have been suggested as alternatives. These
ablation techniques are safe and effective for local tumour control in patients with papillary
thyroid carcinoma, but they may have limited efficacy in the control of regional microscopic
metastasis or minute multifocal carcinoma [11]. Moreover, in patients with inoperable
medullary or anaplastic carcinoma, the efficacy of thermal ablations has not been established.
Some studies showed efficacy (i.e. pain control and cosmetic improvement) of RFA in
treating huge inoperable primary medullary or anaplastic carcinoma, whereas others showed
no clinical improvement after RFA or LA for treating anaplastic thyroid carcinoma [12,13].
 DAFTAR PUSTAKA

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