FINAL EXAMINATION

JANUARY 2014 SEMESTER

COURSE : CLINICAL HAEMATOLOGY

COURSE CODE : MLS 3174
DURATION : 3 HOURS
FACULTY : BIOMEDICAL AND HEALTH SCIENCES
PROGRAMME : BACHELOR OF MEDICAL LABORATORY SCIENCE
LECTURER : MR MOHD JAAMIA QAADIR BIN MOHD BADRIN

INSTRUCTIONS TO CANDIDATES

This question paper consists of three (3) sections:

Section A - 20 questions (Objective Questions)

Section B - 4 questions (Short Answer Questions)
Section C - 3 questions (Essay Questions)

Answer all questions in Section A and B, and only two (2) questions in Section C.

All answer of:

Section A must be answered in OMR objective paper provided

Section B and C must be written in the answer booklet provided.
The answer for each question must start on a new page.

Candidates are NOT ALLOWED to bring any unauthorized items into the examination hall.

Do Not Open the Question Paper Until Instructed

This Question Paper Consists of Eight (8) Printed Pages

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SECTION A: OBJECTIVE QUESTIONS (20 MARKS)

Choose ONE best statement to answer the questions.

1. Which of these cells are commonly measured in packed cell volume testing?

(A) plasma
(B) platelets
(C) leukocytes
(D) erythrocytes

2. Fifty-five percent (55%) of the human blood is composed of

(A) plasma
(B) platelets
(C) leukocytes
(D) erythrocytes

3. Anemia is classified by

(A) Etiology and cell death

(B) Morphology and cell size
(C) Etiology and morphology
(D) Morphology and cell death

4. Intrinsic disorder of the red blood cell destruction can be caused by

(A) platelet
(B) antibody
(C) macrophage
(D) hemoglobin

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5. What property of the normal erythrocytes membrane allows the 7 µM cell to squeeze through
3 µM fenestration in the spleen?

(A) fluidity
(B) elasticity
(C) permeability
(D) transformability

6. Which of the following is an example of cell membrane defect?

(A) Hereditary elliptosis

(B) Hemoglobin C defect
(C) G6PD deficiency effect
(D) Pyruvate kinase deficiency

7. Example of hypochromic microcytic anemia is

(A) thalassemia
(B) aplastic anemia
(C) hemolytic anemia
(D) megaloblastic anemia

8. Which is the BEST description for microcytic anemia?

(A) low MCV

(B) low MCH
(C) high MCV
(D) high MCH

9. Iron deficiency anemia is an example of

(A) aplastic anemia

(B) microcytic anemia
(C) macrocytic anemia
(D) megaloblastic anemia

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10. Which of the following is FALSE on hemolytic anemia?

(A) It can only be inherited.

(B) It can be caused by sickle cell disease.
(C) It can be caused by hereditary spherocytosis.
(D) It can be caused by pyruvate kinase deficiency.

11. The most common clinical features in hemolytic anemia patients are

(A) pallor, styes, pale urine

(B) jaundice, styes, dark urine
(C) pallor, malaise, dark urine
(D) jaundice, malaise, pale urine

12. Which flow is TRUE for haematopoiesis?

(A) differentiation formation development

(B) formation development differentiation
(C) development differentiation formation
(D) formation differentiation development

13. Megaloblastic anemia is caused by

(A) iron deficiency

(B) G6PD deficiency
(C) vitamin B12 deficiency
(D) pyruvate kinase deficiency

14. Which of the following is NOT the laboratory diagnosis for megaloblastic anemia?

(A) endoscopy
(B) diet history
(C) schilling test
(D) liver function test

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15. This cell is smaller than other leukocytes, larger than red blood cells, has transparent
cytoplasm, a round and large nucleus occupying most of cytoplasm. This cell is

(A) monocytes
(B) erythrocytes
(C) lymphocytes
(D) thrombocytes

16. Reticulocyte count in megaloblastic anemia is

(A) normal
(B) increase
(C) decrease
(D) fluctuate

17 Which of the following describes alpha thalassemia?

.
I. Deletion disorder
II. Alpha globin chain affected
III. Comes from maternal and paternal origin
IV. Severity depends on numbers of affected allele

(A) I, II and III

(B) I, II and IV
(C) I, III and IV
(D) I, II, III and IV

18 Which of the following describes beta thalassemia?

.
I. Deletion disorder
II. Beta globin chain affected
III. Loss of alpha globin chain
IV. Severity depends on the mutational changes

(A) I, II and III

(B) I, II and IV
(C) I, III and IV
(D) I, II, III and IV

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19 Which of the following DOES NOT describe the mechanisms of hemostasis?

.
I. Fibrinoplasia
II. Blood coagulation
III. Vascular constriction
IV. Platelet plug formation

(A) I, II and III

(B) I, II and IV
(C) II, III and IV
(D) I, II, III and IV

20 Which of the following BEST describes hemophilia?

.
I. Got two types A and B.
II. A type is mainly in males.
III. B type is mainly in female.
IV. Sex linked recessive disorder.

(A) I, II and III

(B) I, II and IV
(C) II, III and IV
(D) I, II, III and IV

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SECTION B: SHORT ANSWER QUESTIONS (40 MARKS)

Answer ALL questions.

1. a. Briefly describe the function of von Willebrand factor (5 Marks)

b. What are the FIVE (5) laboratory investigations for von Willebrand factor disease?
(5 Marks)

2 a. Briefly describe the laboratory findings for sickle cell disease. (6 Marks)

b. Briefly describe in general the characteristics of sickle cell disease. (4 Marks)

3 a. State SIX (6) clinical features of iron deficiency anemia. (6 Marks)

b. List FOUR (4) types of hypochromic microcytic anemia. (4 Marks)

4. a. Briefly describe in general the classification of hemolytic anemia. (5 Marks)

b. What are the FIVE (5) examples for acquired hemolytic anemia? (5 Marks)

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SECTION C: ESSAY QUESTIONS (40 MARKS)

Answer TWO (2) questions only.

Question 1

In your own words, outline Thalassemia diseases in details including both alpha and beta types.
(20 Marks)

Question 2

In your own words, summarize anemia into THREE categories based on the laboratory findings
of red blood cell tests. (20 Marks)

Question 3

Illustrate and explain the mechanisms of hemostasis.

(20 Marks)

END OF QUESTION PAPER

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