Title:

Release of Polyphenols from Liposomes Loaded with Echinacea purpurea

Authors:
RAMONA DANIELA PAVALOIU1 , FAWZIA SHA AT1,2*, CORINA BUBUEANU1 , GEORGETA NEAGU1 ,
ADRIAN ALBULESCU1 , CRISTINA HLEVCA1 , GHEORGHE NECHIFOR2 * 1 National Institute for Chemical-
Pharmaceutical Research and Development - ICCF Bucharest, 112 Vitan Road, 031299, Bucharest,
Romania 2 Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science,
Analytical Chemistry and Environmental Engineering Department, 1-7 Gh. Polizu Str., 011061, Bucharest,
Romania

Problems Associated with the Research:

1. Polyphenols show degradation in GIT media.

2. Polyhenols possess low biodisponibility due to poor water solubility.
3. Polyphenols are bitter in taste.

How to overcome the problems?

The advantages of encapsulation of polyphenols in liposomes are better absorption, decrease of toxicity
and side effects, decrease of frequency and dose of administration; consequently, the patient
compliance and the therapeutic effectiveness are improved.

Reference:

https://www.researchgate.net/profile/Gheorghe_Nechifor/publication/328065855_Release_of_Polyphe
nols_from_Liposomes_Loaded_with_Echinacea_purpurea/links/5bb5e51d92851ca9ed380ea4/Release-
of-Polyphenols-from-Liposomes-Loaded-with-Echinacea-purpurea.pdf