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Medical Engineering and Physics 40 (2017) 110–116

Contents lists available at ScienceDirect

Medical Engineering and Physics


journal homepage: www.elsevier.com/locate/medengphy

Technical note

Evaluation of the magnitude of hip joint deformation in subjects with


avascular necrosis of the hip joint during walking with and without
Scottish Rite orthosis
Mohammad Taghi Karimi a,b, Ali Mohammadi c,d, Mohammad Hossein Ebrahimi c,d,∗,
Anthony McGarry e
a
Orthotics and Prosthetics Department, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
b
Musculoskeletal Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
c
Faculty of Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran
d
Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
e
Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK

a r t i c l e i n f o a b s t r a c t

Article history: The femoral head in subjects with leg calve perthes disease (LCPD) is generally considerably deformed. It
Received 26 January 2016 is debatable whether this deformation is due to an increase in applied loads, a decrease in bone mineral
Revised 8 October 2016
density or a change in containment of articular surfaces. The aim of this study was to determine the
Accepted 23 October 2016
influence of these factors on deformation of the femoral head.
Two subjects with LCPD participated in this study. Subject motion and the forces applied on the af-
Keywords: fected leg were recorded using a motion analysis system (QualsisTM ) and a Kistler force plate. OpenSim
LCPD, orthosis software was used to determine joint contact force of the hip joint whilst walking with and without a
Scottish Rite Scottish Rite orthosis. 3D Models of hip joints of both subjects were produced by Mimics software. The
Walking
deformation of femoral bone was determined by Abaqus.
Joint contact force
Mean values of the force applied on the leg increased while walking with the orthosis. There was
Hip joint deformation
no difference between bone mineral density (BMD) of the femoral bone of normal and LCPD sides (p-
value>0.05) and no difference between hip joint contact force of normal and LCPD sides. Hip joint con-
tainment appeared to decrease follow the use of the orthosis.
It can be concluded that the deformation of femoral head in LCPD may not be due to change in BMD
or applied load. Although the Scottish Rite orthosis is used mostly to increase hip joint containment, it
appears to reduce hip joint contact area. It is recommended that a similar study is conducted using a
higher number of subjects.
© 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

1. Introduction A variety of different approaches to treatment have been used


for LCPD, including surgery, the use of orthoses, observation and
In Leg Calve Perthes Disease (LCPD) the blood supply of femoral physical therapy [5–12]. The main reason for treatment is to re-
head is disconnected and the femoral head temporarily dies [1]. duce deformation of the femoral bone [7] which may increase the
The incidence of this disease varies from a country to country from incidence of hip joint degeneration and pain in adolescence [13,14].
0.45 to 10.5 per 10 0,0 0 0 and occurs mostly in children between 5 Treatment approaches used to decrease femoral head deforma-
and 12 years [1–4]. Although it is claimed that genetic or depriva- tion are based on reducing the applied load on the femoral head
tion factors influence the incidence of this disease, its etiology is and increasing hip joint containment [5,7,10,15,16]. Containment of
likely to be multifactorial and is not clear [1]. the femoral head within acetabulum is achieved by putting the hip
joint in a few degrees of abduction and internal rotation until the
femoral epiphysis is well inside Perkins line [5,12,17].

Corresponding author at: Department of Applied Physics, University of Eastern Offloading of the hip joint has being conducted using assis-
Finland, Yliopistonranta 1 F POB 1627 FI-70211 Kuopio, Finland.
tive devices such as the Birmingham splint, Snider sling, or Ischial
E-mail addresses: Karimi@rehab.mui.ac.ir (M.T. Karimi),
ali.mohammadi.bioengineering@gmail.com (A. Mohammadi),
weight bearing orthoses [10,11,15,16]. It is recommended in liter-
ebrahimi.bioengineering@gmail.com (M.H. Ebrahimi), mcgarry@strath.ac.uk (A. Mc- ature that subjects with LCPD should use orthoses to reduce the
Garry). applied loads on the femoral head during ambulation [7].

http://dx.doi.org/10.1016/j.medengphy.2016.10.015
1350-4533/© 2016 IPEM. Published by Elsevier Ltd. All rights reserved.
M.T. Karimi et al. / Medical Engineering and Physics 40 (2017) 110–116 111

Table 1 subjects with LCPD and was originally developed at Scottish Rite
The characteristics of the subjects participated in this study.
hospital for crippled children in Atlanta in 1971. This orthosis con-
Subject Age(Years) Weight(kg) Height(CM) sists of three main parts, including plastic thigh cuffs, a pelvic band
Subject 1 7 20.1 105 and a single axis hip hinge. The main reason to use this orthosis
is to put the hip joint in an abducted and internally rotated pos-
Subject 2 7 20.5 97
ture. [18,24]. It should be emphasized that the orthosis was built
specifically for each subject and the subjects used their orthosis for
at least 6 months before participated in this study. The following
The main LCPD treatment aims are to contain and prevent parameters were evaluated in this study: Spatiotemporal gait pa-
further deformity of the femoral head; relieve painful symptoms rameters during walking with and without orthosis, forces applied
and restore hip joint range of motion [7]. Results of various re- on the leg, kinematic of the lower limb joints and pelvic, hip joint
search studies demonstrate no difference between the outputs of moments, joint contact forces of the hip joints, the containment of
treatment based on surgery, orthoses, physical therapy or observa- the hip joint in various aligned positions, and the stress and strain
tional treatment. This means current treatment pathways have not of hip joint in walking with and without orthosis.
demonstrated success in relation to treatment aims [7].
It remains unclear exactly why the femoral bone is deformed in
this disease. The deformation of the femoral bone is currently pre- 3. Procedure
sumed to be as a result of increase in the applied loads, decrease
in bone density or a decrease in femoral head containment within 3.1. Kinetic and kinematic analysis
acetabular cavity [7].
Results of previous studies have demonstrated no significant A motion analysis system consisted of seven high speed cam-
difference between forces applied between normal and LCPD legs era (Qualysis motion analysis system) and Kistler force plates were
[18,19]. Moments applied on the hip joint in the LCPD side may used to collect the kinetic and kinematic parameters. Twenty-two
actually be less than that of normal side [20]. It was concluded markers were attached on the right and left anterior and poste-
that these subjects altered their walking pattern to decrease the rior superior iliac spines, right and left greater trochanters, right
hip joint moment and hence load on hip joint [21,22]. Although and left medial and lateral sides of knee joint, right and left me-
previous studies have examined hip joint load of LCPD subjects, all dial and lateral malleolus, first and fifth metatarsal heads, right and
are based on inverse dynamics and kinematics [18,19,22]. To the left heels and right and left acromioclavicular joints. Additionally,
best of our knowledge, no study on hip joint contact forces has four markers clusters were attached on the lateral side of thighs
previously been described in this group of subjects. and shanks in both right and left sides. The subjects were asked
Bone mineral density (BMD) is another important parameter to walk at a comfortable self-selected speed with and without the
which is mostly dependent on applied femoral load. Baily et al. orthosis. Tests were repeated to collect five successful trials.
demonstrated that BMD of femoral head in LCPD side was less Force plate data and cameras were collected with frequency of
than that of sound side, which may be due to decrease in loads ap- 120 Hz. Data was filtered with Butterworth low pass filter with
plied. It was demonstrated that the maximum difference of density cut off frequency of 10 Hz. Markers were labeled in QualysisTM
related to the femoral neck region [20]. Based on these findings it Tract Manager Software and were exported as 3-D files. Files were
may be fair to conclude that a decrease in BMD may be related to opened with MokkaTM software to produce trc files to be analyzed
a reduction in applied load, which should return to expected val- with OpenSIMTM software. OpenSIMTM software is open source soft-
ues if the subjects walked normally. ware developed by Stanford University, USA. It can be used to anal-
Although the theory of femoral head containment within the ysis kinetic, kinematic, muscles forces, muscles length and joint
acetabulum was described more than 50 years ago, there are no contact forces. Fig. 1 shows the procedure used to determine joint
studies which evaluate the effects of this hip joint position on in- contact forces of the hip joint by use of OpenSIMTM software [25].
crease of the contact area of the hip joint [7]. The scaling was done with high accuracy as was recommended
There are no studies which evaluate hip joint contact forces in by OpenSIMTM developer [25], the RMS of error was less than 2 mm
LCPD. The effect of hip joint containment on the acetabular contact for whole model. Moreover, the RMS of model error was evalu-
area in these subjects remains undecided; there is little informa- ated in inverse kinematic frame by frame. (Based on the reports
tion on the effect of containment on the stress and final deforma- produced by the software automatically the RMS of error was less
tion of the femoral bone. Therefore, the aim of this study was to than 2 cm.)
examine the effect of orthotic management on the resulting stress
which develops in the hip joint and to determine the effects of 3.2. Producing 3-D files of hip joint
alignment change in relation to this stress.
3-D modeling of the hip joint with specific material assign-
2. Methods ment was done by use of MimicsTM and AbaqusTM software, based
on CT scan slices of the patient’s hip joint. Hip joint files were
Two seven year old boys with symptoms of avascular necro- opened in MimicsTM software to produce a 3-D mask and differ-
sis of the hip joint participated in this study, Table 1. Both had ent segments (femoral and pelvic) modeled individually. Resulting
involvement of hip joint on the right side. The severity of LCPD segments were exported to AbaqusTM software to change the for-
was determined based on the latest X-ray of the patients (Mose mat of the mesh from ‘tri’ to ‘tet’. INP files were then imported to
et al.) [23]. Ethical approval was obtained from Isfahan University MimicsTM to assign the material.
of Medical Sciences, Ethical Committee. A consent form was signed The software defines a number of sampling points within each
by the parents of each participant before date collection. element and interpolates the gray level relating to their coordinate
Both subjects were asked to walk with and without Scottish from the original CT. Gray level is proportional to apparent bone
Rite orthosis. This is a well-developed orthosis for the subjects density. Young Modules (E) was automatically calculated by mimics
with LCPD and holds the hip joint in some degree of abduction software based on equation developed by Schileo et al. and Morgan
and medial rotation to increase hip joint containment. The Scot- et al. [26,27]:
tish Rite orthosis is one of the most popular used orthoses for the E = 6850ρ 1.49
112 M.T. Karimi et al. / Medical Engineering and Physics 40 (2017) 110–116

Table 2
The mean values of spatiotemporal gait parameters of both subjects while walking
with and without orthosis.

Condition Step length(cm) Speed(m/min) Cadence(steps/min)

Subject 1
Without orthosis 85.6 ± 2.5 51.5 ± 2.17 120 ± 2.75
With orthosis 76 ± 1.7 43 ± 3.04 118.6 ± 4.04
P-value 0.35 0.01 0.003
Subject 2
Without orthosis 73.7 ± 14.2 40.9 ± 5.86 113.7 ± 24.2
With orthosis 60.3 ± 5.8 35.13 ± 2.74 116.33 ± 3.21
P-value 0.42 0.075 0.08

without orthosis). The difference between the mean values of the


gait parameters was evaluated by use of two sample tests.

4. Results

The mean values of the gait parameters of both subjects while


walking with orthosis and without orthosis are shown in Table 2.
As can be seen from this table, walking speed and stride length
decreased especially while walking with orthosis (P-value of dif-
ference < 0.05 for subject 1).
Hip and pelvic kinematics were also evaluated in this study,
Table 3. Although the range of flexion and extension motions of hip
joint did not decrease significantly in subject 1, they did so in sub-
ject 2 following the use of orthosis (29.75 ± 3.14 without ortho-
sis vs. 9.6 ± 1.52 when walking with an orthosis). In contrast, the
hip joint range of motion in frontal plane decreased significantly
in both subjects (P-value < 0.05). The pelvic range of motion in the
frontal plane increased notably in both of participants (Table 3). Al-
though the peaks of the ground reaction force components applied
on the leg increased while walking with orthosis, the difference
was only significant for mediolateral force (P-value = 0.04 and 0.01
for the first and second, subjects, respectively), Table 4. Most of
the peaks of hip joint forces increased significantly during walking
with the orthosis in both subjects (p-value<0.05), Table 5.
The hip joint contact force of both subjects while walking with
and without orthosis are shown in Table 5. Vertical component
peaks of hip joint contact force were 13.74 ± 6.13 and 6.27 ±
2.53 N/BW in subject 1 in walking without and with the orthosis,
respectively. In contrast, it was 9.96 ± 3.54 and 12.8 ± 2.1 N/BW,
in subject 2 for walking without and with orthosis. Although the
Fig. 1. The procedures used in this research study. mean values of anteroposterior component of hip joint contact
force increased in both subjects, the difference was not significant
(p-value > 0.05). The hip joint contact force of the sound side was
also evaluated in this study. As can be seen from Table 6, there was
In which, E was Young Modules of elasticity and ρ was appear- no difference between hip joint contact force between involved
ance bone density. and healthy sides (p-value>0.05).
Hip joint alignment changes (femoral head and pelvic compo- Mean values of femoral bone density and femoral bone Young
nents) were simulated using MimicsTM software. The femoral bone Modules of elasticity of the involved side were 805129.9 ±
was placed in abduction, external rotation, and internal rotation 467632.5 g/m3 and 4770396420 ± 2770722483 Pascal for subject
with respect to the acetabulum (pelvic). The influence of changes 1 and 90 0 077.3 ± 564158 g/m3 and 4648782493 ± 2642671981
in alignment of hip joint on joint containment was determined Pascal for subject 2, respectively. There was no difference between
based on the number of nodes of femoral head which were cov- density and Young modulus of elasticity between involved and
ered by acetabulum of hip bone. Resulting femoral head stress sound sides, Table 7. The results of joint containment in various
developed in various positions and deformation was determined alignment of hip joint are shown in Table 8. As can be seen from
based on the forces obtained from OpenSIMTM software. It was this table, the maximum contact area of hip joint was in neutral
done by help of Abaqus software. Due to lack of information re- position in both subjects. However, the minimum number of nodes
garding stress analysis of femoral bone in children the analysis was was in abduction and internal rotation in subject 1 and abduction
done based on elastio-plastic approach in AbaqusTM software. in subject 2.
Mean values of the kinematic, kinetic parameters and joint con- Femoral bone deformation and stress magnitude in the femur,
tact forces were determined in walking with and without ortho- (based on the elastic approach), are shown in Fig. 2. As can be
sis conditions. At least 10 successful trials for each subject was seen from this figure, the stress developed was more than the
collected under each condition. Statistical analysis was conducted stress which can feasibly be tolerated by the bone. Therefore, all
separately for each subject, based on conditions (walking with and analysis was conducted based on an elasto-plastic approach. The
M.T. Karimi et al. / Medical Engineering and Physics 40 (2017) 110–116 113

Table 3
The kinematic of hip and pelvic in both subjects during walking with and without orthosis.

Condition Hip X (degree) Hip Y (degree) Hip Z (degree) Pelvic X (degree) Pelvic Y (degree) Pelvic Z (degree)

Subject 1
Without orthosis 27.7 ± 7.3 12 ± 30 10.8 ± 4.5 15 ± 10.3 6.6 ± 0.28 14.3 ± 5.03
With orthosis 26.5 ± 3.04 6.16 ± 1.60 23.30 ± 2.08 9 ± 5.1 17.3 ± 2.3 19.6 ± 0.57
P-value 0.43 0.035 0.12 0.219 0.007 0.01
Subject 2
Without orthosis 29.75 ± 3.40 5.87 ± 0.25 5.87 ± 0.25 6.3 ± 1.7 5.7 ± 0.6 15.37 ± 1.60
With orthosis 9.66 ± 1.52 5.16 ± 0.28 18.16 ± 12.04 8.1 ± 2.5 25.8 ± 2.2 45.6 ± 2.30
P-value 0.00 0.01 0.19 0.18 0.001 0.00

Table 4
The mean values of the ground reaction force components and peaks of the moments applied on hip joint.

Condition Fx(N) Fy(N) Fz(N) Mx1 Mx2 My Mz1 Mz2

Subject 1
Without orthosis 46.4 ± 18.67 293.6 ± 5.77 18.3 ± 2.86 15 ± 5.56 27 8 ± 3.46 3±1 1.83 ± 0.28
With orthosis 55 ± 14.14 332.9 ± 15.7 38 ± 5.65 17.66 ± 10.21 25.16 ± 19.8 28.1 ± 0.76 8.16 ± 1.89 1.83 ± 0.57
P-value 0.3 0.08 0.04 0.358 0.44 0.003 0.012 0.5
Subject 2
Without orthosis 24.5 ± 2.12 252 ± 7.77 30.9 ± 2.96 6.37 ± 2.80 2.37 ± 0.47 4.87 ± 3.42 4.12 ± 2.46 0.375 ± 0.25
With orthosis 37.5 ± 10.6 272.5 ± 14.4 58.5 ± 4.1 4 ± 2.64 15.66 ± 9.01 16.5 ± 3.53 7.33 ± 0.76 2.66 ± 2.88
P-value 0.16 0.135 0.01 0.15 0.06 0.030 0.037 0.15

Table 5
The mean values of the joint contact forces of Perthes side during walking with and without orthosis.

Condition Anteroposterior force (N/BW) Vertical force (N/BW) Mediolateral force (N/BW)

Subject 1
Without orthosis 6.17 ± 0.71 13.74 ± 6.13 5.30 ± 1.68
With orthosis 7.15 ± 2.12 6.27 ± 2.53 5.96 ± 0.09
P-value 0.31 0.41 0.28
Subject 2
Without orthosis 2.895 ± 6.45 9.96 ± 3.54 4.18 ± 1.38
With orthosis 5.9 ± 2.48 12.8 ± 2.1 9.12 ± 2.07
P-value 0.083 0.12 0.015

Table 6
The mean values of joint contact forces of healthy side during walking with and without orthosis.

Condition Anteroposterior force (N/BW) Vertical force (N/BW) Mediolateral force (N/BW)

Subject 1
Normal side 1.22 ± 0.09 7.2 ± 5.32 3.06 ± 2.21
Perthes side 5.04 ± 0.80 8.28 ± 0.54 6.32 ± 0.04
Subject 2
Normal side 2.74 ± 0.38 12.37 ± 7.63 4.97 ± 3.06
Perthes side 3.91 ± 1.86 13.47 ± 8.11 8.11 ± 2.36

Table 7 orthosis. Regarding the effects of alignment on femoral head de-


The mean values of Young modulus of elasticity (E) and bone mineral density of
formation, the deformation in abduction and neutral position was
healthy and Perthes sides.
less than that in other conditions.
Condition Density (gr/m3 ) E modules (Pascal)

Subject 1
Healthy 784604.2 ± 445901.4 4619368361 ± 3252805990 5. Discussion
Perthes 805129.9 ± 467632.5 4770396420 ± 2770722483
P-value 0.46 0.46
Although the etiology of LCPD was described over 100 years
Subject 2
ago, there is still a lack of consensus on which treatment approach
Healthy 928249.5 ± 570285.2 4941866205 ± 3056360410
Perthes 90 0 077.3 ± 564158 4648782493 ± 2642671981 should be used to decrease the deformities associated with this
P-value 0.45 0.41 disease. Although various treatment approaches have being used
to decrease the deformation of femoral head and decrease the in-
cidence of hip joint degenerative change, most of them are not suc-
cessful [7]. One of the broadly used methods to reach to this goal
results of deformation of femoral bone in various aligned positions is the use of an orthosis. Therefore, the aim of this study was to
are shown in Table 9. The average deformation of femoral bone determine the effect of the use of an orthosis to decrease the load
was 2.318 mm and 1.964 mm in subject 1 while walking with and applied on hip joint and hence the deformation of femoral head.
without orthosis. Although in subject 1 using the orthosis reduced Additionally, the study aimed to evaluate the influence of femoral
the deformation of the femoral head, in subject 2 the deformation alignment change on containment and stress developed in the hip
of the bone in walking with orthosis was more than that without joint.
114 M.T. Karimi et al. / Medical Engineering and Physics 40 (2017) 110–116

Table 8
The number of nodes of femoral head in contact with acetabulum in various position of hip joint.

Condition Nude Abduction Abduction and external rotation Abduction and internal rotation

Subject 1
Containment (Number of nodes) 390 193 184 69
Subject 2
Containment (Number of nodes) 207 135 150 231

Table 9
The deformation of femoral head in various aligned position of the hip joint.

Condition Nude Abduction Abduction and Abduction and


external rotation internal rotation

Subject 1
Displacement without Minimum 1.906 2.694 2.308 1.831
orthosis (mm) Average 2.318 2.319 2.948 2.375
Maximum 2.731 1.943 3.588 2.919
Displacement with orthosis Minimum 1.611 1.750 1.737 1.637
(mm) Average 1.964 2.096 2.215 2.107
Maximum 2.317 2.442 2.693 2.576
Subject 2
Displacement without Minimum 2.698 2.754 2.548 2.898
orthosis (mm) Average 3.289 3.479 3.334 3.546
Maximum 3.881 4.205 4.121 4.194
Displacement with orthosis Minimum 6.817 6.780 6.077 6.801
(mm) Average 8.066 8.220 7.568 8.029
Maximum 9.315 9.659 9.059 9.257

Fig. 2. The stress and strain of femoral head in both Perthes subjects based on elastic approach.

Femoral bone deformation in this disease may be due to three ation in hip joint load. No other previous studies have been iden-
main reasons which include: Increase in loads applied on the hip tified to examine the joint contact force in subjects with LCPD.
joint, change in containment of articular surfaces and decrease in The results of BMD of both subjects demonstrated no difference
bone mineral density. As can be seen from the results of this study between BMD and Young modulus of elasticity of LCPD and sound
presented in Table 6, there was no difference between joint con- sides, Table 7. Results of this part of this research did not support
tact forces of LCPD affected and healthy sides. It may therefore be the finding of Bailey et al. [20]. Some parameters such as the time
concluded that femoral bone deformation is not related to an alter- between start of disease and follow up may be the reason for the
M.T. Karimi et al. / Medical Engineering and Physics 40 (2017) 110–116 115

difference. It should be noted that the BMD in the current research 6. Conclusion
was measured based on Shailey et al. approach, which was con-
ducted using MimicsTM software [26]. The BMD of different parts Whilst considering the limited number of participants in this
of femur (up to 5 cm below the greater trochanter) were evalu- study, it may be concluded that the deformation of femoral bone
ated in this study. Although there was no difference between the is neither due to a change in hip joint load or a change in bone
mean values of BMD of femur, the BMD of specific parts may be mineral density. Additionally, results indicate that the containment
decreased due to this disease. Overall, no significant difference was of the hip joint in the positions aligned by use of the Scottish Rite
detected between the BMD of LCPD and sound sides. orthosis does not increase the contact area of hip joint in all sub-
Results demonstrate that femoral head deformation in LCPD is jects. It is recommended that further studies be conducted using a
not due to a change in BMD or applied load. The remaining rea- larger sample size.
son discussed may be due to a change in hip joint containment.
The difference between hip joint containment between LCPD and Declarations
normal subjects was not evaluated in this study. Therefore, it is
recommended that this parameter should be considered in the fu- The following additional information is required for submission.
ture. Please note that failure to respond to these questions/statements
However, subjects with LCPD are recommended to use Scottish will mean your submission will be returned to you. If you have
Rite orthosis to increase joint containment and to reduce applied nothing to declare in any of these categories then this should be
loads. The results of this research also highlighted that although stated.
the walking speed and stride length decreased significantly while
walking with orthosis, Table 2, the moments applied on hip joints Conflict of interest
and some components of ground reaction force increased signifi-
cantly, Tables 4 and 5. This is the same as the results of the study All authors must disclose any financial and personal relation-
done by Karimi et al. [18]. However the results of joint contact ships with other people or organizations that could inappropriately
force demonstrated that although the mediolateral component of influence (bias) their work. Examples of potential conflicts of inter-
hip joint contact force increased in both subjects following the use est include employment, consultancies, stock ownership, honoraria,
of the orthosis, the mean value of vertical components increased in paid expert testimony, patent applications/registrations, and grants
subject 2 (it decreased in subject 1), Table 5. Results of this study or other funding.
therefore do not support the use of orthosis to reduce hip joint
contact force. Ethical approval
The results of stress analysis demonstrated that stress devel-
oped in the femoral bone based on elastic approach exceeded Work on human beings that is submitted to Medical Engi-
the stress which may feasibly be tolerated by the femur. There- neering & Physics should comply with the principles laid down
fore, it was decided that the stress analysis of the bone be con- in the Declaration of Helsinki; Recommendations guiding physi-
ducted using an elasto-plastic approach. The results of stress anal- cians in biomedical research involving human subjects. Adopted
ysis demonstrated that the deformation of femoral head decreased by the 18th World Medical Assembly, Helsinki, Finland, June 1964,
in walking with orthosis condition (in neutral condition) in subject amended by the 29th World Medical Assembly, Tokyo, Japan, Octo-
1, compared to an increase in subject 2. As this part of analysis ber 1975, the 35th World Medical Assembly, Venice, Italy, October
was done under neutral condition the difference in deformation of 1983, and the 41st World Medical Assembly, Hong Kong, Septem-
femoral bone may be due to change in hip joint contact force. As ber 1989. You should include information as to whether the work
can be seen from Table 5, the vertical component of joint contact has been approved by the appropriate ethical committees related
force decreased and increased slightly in subjects 1 and 2, respec- to the institution(s) in which it was performed and that subjects
tively. gave informed consent to the work.
The effect of hip joint alignment change was also evaluated in
this study. Results indicate that positioning of the hip joint artic- References
ular surfaces in a neutral position may provide maximum contact
[1] Wynne-Davies RG J. The aetiology of LCPD’ disease. Genetic, epidemiological
area, Table 8. Although abduction and internal rotation increased and growth factors in 310 Edinburgh and Glasgow patients. J Bone Joint Surg
the contact area of the hip joint surface in subject 2, it deceased 1978;60:6–14.
the contact surface in subject 1. It may therefore be concluded that [2] Pillai A, Atiya S, Costigan PS. The incidence of LCPD’ disease in Southwest Scot-
land. J Bone Joint Surg 2005;87(11):1531–5.
the position achieved by use of the orthosis may be not optimal in [3] Purry NA. The incidence of LCPD’ disease in three population groups in the
promoting maximum joint containment. Eastern Cape region of South Africa. J Bone Joint Surg 1982;64(3):286–8.
The results of stress–strain analysis demonstrated that use of [4] Rowe SM, Jung ST, Lee KB, Bae BH, Cheon SY, Kang KD. The incidence of LCPD’
disease in Korea: a focus on differences among races. J Bone Joint Surg Br
orthosis may decrease the deformation of femoral head in subject 2005;87(12):1666–8.
1 but increased it in subject 2. As this part of comparison was [5] Curtis BH, Gunther SF, Gossling HR, Paul SW. Treatment for Legg-LCPD dis-
done in neutral position it can be concluded that it may be due ease with the Newington ambulation-abduction brace. J Bone Joint Surg
1974;56(6):1135–46.
to a change in applied loads on hip joint. As can be seen from
[6] Froberg L, Christensen F, Pedersen NW, Overgaard S. The need for total hip
Table 6, the vertical component of hip joint contact force in sub- arthroplasty in LCPD disease: a long-term study. J Clin Orthop Relat Res 2011
ject 1 in walking with orthosis was less than that of normal walk- Apr;469(4):1134–40.
[7] Karimi MT, McGarry T. A comparison of the effectiveness of surgical and non-
ing, however, this increased in subject 2. Alignment of the hip joint
surgical treatment of legg-calve-LCPD disease: a review of the literature. J Adv
in the aforementioned positions by use of orthosis seems to in- Orthop 2012;2012:1–9.
crease the deformation of femoral head, due to decrease in joint [8] Kelly FB, Canale ST, Jones RR. Legg-Calve-LCPD disease. Long-term evaluation
containment. of non-containment treatment. J Bone Joint Surg 1980;62(3):400–7.
[9] Kim WC, M H, Tsuchida Y, Kawamoto K. Outcomes of new pogo-stick brace for
The main limitation of this study was the number of partici- Legg-Calve-LCPD’ disease. J Pediatr Orthop Part B 2006;15(2):98–103.
pants. It is recommended that future studies should be conducted [10] Martinez AG, Weinstein SL, Dietz FR. The weight-bearing abduction brace for
using a larger sample size. Moreover, it is recommended that bone the treatment of Legg-LCPD disease. J Bone Joint Surg 1992;7(1):12–21.
[11] Meehan PL, Angel D, Nelson JM. The Scottish Rite abduction orthosis for the
mineral density of different parts of bone be evaluated in an in- treatment of Legg-LCPD disease. A radiographic analysis. J Bone Joint Surg
creased number of subjects with LCPD. 1992;74(1):2–12.
116 M.T. Karimi et al. / Medical Engineering and Physics 40 (2017) 110–116

[12] Muirhead-Allwood W, Catterall A. The treatment of LCPD’ disease. The results [21] Westhoff B, Petermann A, Hirsch MA, Willers R, Krauspe R. Computerized gait
of a trial of management. J Bone Joint Surg 1982;64(3):282–5. analysis in Legg Calve LCPD disease–analysis of the frontal plane. J Gait Posture
[13] Heesakkers N, van Kempen R, Feith R, Hendriks J, Schreurs W. The long-term 2006 Oct;24(2):196–202.
prognosis of Legg-Calve-LCPD disease: a historical prospective study with a [22] Westhoff B, Martiny F, Reith A, Willers R, Krauspe R. Computerized gait anal-
median follow-up of forty one years. J Int Orthop 2015 May;39(5):859–63. ysis in Legg-Calve-LCPD disease–analysis of the sagittal plane. J Gait Posture
[14] Yrjonen T. Long-term prognosis of Legg-Calve-LCPD disease: a meta-analysis. J 2012 Apr;35(4):541–6.
Pediatr Orthop B. [Meta-Anal] 1999 Jul;8(3):169–72. [23] Mose K. Methods of measuring in Legg-Calve-LCPD disease with special regard
[15] Aksoy MC, Caglar O, Yazici M, Alpaslan AM. Comparison between braced and to the prognosis. J Clin Orthop Relat Res 1980;150:103–9.
non-braced Legg-Calve-LCPD-disease patients: a radiological outcome study. J [24] Meehan PL, Angel D, Nelson JM. The Scottish Rite abduction orthosis for the
Ppediatr Orthop Part B 2004;13(3):153–7. treatment of Legg-LCPD disease. A radiographic analysis. J Bone Joint Surg Am
[16] Bobechko WP, McLaurin CA, Motloch WM. Toronto Orthosis for Legg-LCPD Dis- 1992 Jan;74(1):2–12.
ease. J Orthot Prosthet 1968;12(2):36–41. [25] Delp SL, Anderson FC, Arnold AS, Loan P, Habib A, John CT, et al. OpenSim:
[17] Evans DL, Lloyd-Roberts GC. Treatment in Legg-Calve-LCPD’ disease; a com- open-source software to create and analyze dynamic simulations of move-
parison of in-patient and out-patient methods. J Bone Joint Surg Br Vol 1958 ment. IEEE Trans Biomed Eng, 2007 Nov;54(11):1940–50.
May;40-B(2):182–9. [26] Schileo E, Taddei F, Cristofolini L, Viceconti M. Subject-specific finite element
[18] Karimi M, Sedigh J, Fatoye F. Evaluation of gait performance of a participant models implementing a maximum principal strain criterion are able to es-
with LCPD disease while walking with and without a Scottish-Rite orthosis. J timate failure risk and fracture location on human femurs tested in vitro. J
Prosthet Orthot Int 2013 June;37(3):233–9. Biomech 2008;41(2):356–67.
[19] Svehlik M, Kraus T, Steinwender G, Zwick EB, Linhart WE. Pathological gait in [27] Morgan EF, Bayraktar HH, Keaveny TM. Trabecular bone modulus-density rela-
children with Legg-Calve-LCPD disease and proposal for gait modification to tionships depend on anatomic site. J Biomech 2003 July;36(7):897–904.
decrease the hip joint loading. J Int Orthop 2012 June;36(6):1235–41.
[20] Bailey DA, Faulkner RA, Kimber K, Dzus A, Yong-Hing K. Altered loading pat-
terns and femoral bone mineral density in children with unilateral Legg–
Calve-LCPD disease. J Med Sci Sports Exerc [Res Support, Non-U.S. Gov’t] 1997
Nov;29(11):1395–9.

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