1. The TIMI and GRACE scores are used to assess mortality in patients with ST elevation myocardial infarction (STEMI).
2. Heart failure goals include a cardiac index >2.2, pulmonary capillary wedge pressure <18 mmHg, mean arterial pressure >60 mmHg, and systemic vascular resistance <800 dynes·sec·cm−5.
3. Paroxysmal atrial fibrillation lasts less than 7 days, persistent lasts 7 days to 1 year, and permanent lasts over 1 year.
1. The TIMI and GRACE scores are used to assess mortality in patients with ST elevation myocardial infarction (STEMI).
2. Heart failure goals include a cardiac index >2.2, pulmonary capillary wedge pressure <18 mmHg, mean arterial pressure >60 mmHg, and systemic vascular resistance <800 dynes·sec·cm−5.
3. Paroxysmal atrial fibrillation lasts less than 7 days, persistent lasts 7 days to 1 year, and permanent lasts over 1 year.
1. The TIMI and GRACE scores are used to assess mortality in patients with ST elevation myocardial infarction (STEMI).
2. Heart failure goals include a cardiac index >2.2, pulmonary capillary wedge pressure <18 mmHg, mean arterial pressure >60 mmHg, and systemic vascular resistance <800 dynes·sec·cm−5.
3. Paroxysmal atrial fibrillation lasts less than 7 days, persistent lasts 7 days to 1 year, and permanent lasts over 1 year.
Heart failure goals (CI, PCWP, MAP, CI >2.2, PCWP <18, MAP >60, SVR <800 SVR) Difference between interval and Intervals have waves, segments don’t segment AFib suppression Amiodarone AFib prophylaxis after CABG Amiodaron VTach characteristics Regular rhythm, wide QRS Time needed with triple anticoagulation It is only recommended for one month: 2 antiplatelets + oral anticoagulants after PCI Difference between paroxysmal, Paroxysmal <7 days, Persistent 7 days – 1 year, Permanent >1 year persistent and permanent AFib Echo “BART” Blue – Away, Red – Towards Bubble study interpretation <4 beats: shunt, 4-7: indeterminant, >7: pulmonary shunt Indication to lower apixaban dose to 2.5 >80 yo, Cr >1.5, Weight: <60 kg mg BID instead of 5 mg BID Sever Aortic Stenosis Criteria Mean Gradient: 40, Vmax: 400 cm, Area: < 1 cm Wall abnormalities in Takatsubo There is hypokinesis at the point of the ventricle and hyperkinesia at the base. cardiomyopathy Reverse Takatsubo: other way around Echo characteristic of mitral valve in Posterior leaflet is fixed. Looks like a “hockey stick” rheumatic disease Indication to increase furosemide dose If in the morning you weigh >3 lbs more than the previous day. Take 20 additional at home mgs. Prophylaxis for Bicuspid Aortic Valve Not indicated Digoxin effectivity during exercise Digoxin only works with HR at rest, will not improve function during periods of exercise New HTN Classification Elevated BP: 120-129/80, Stage 1 HTN: 130-139/80-89, Stage 2 HTN: >140/>90 BP Goal for PX with CV Risk >10 and 130/90 (plus TX for risk factors) HTN COPD most common arrhythmia Multifocal atrial tachycardia Most common SVT AVNRT ST changes in pericarditis ST elevations WITHOUT reciprocal ST depressions Definition of Low Voltage in EKG <5 mV in limb leads; <10 mV in precordial leads Hypertrophic cardiomyopathy EKG Dager Q waver (v5-v6) + high voltaje characteristics Q differences in infarction vs Infarction Q >40 ms; hypertrophy Q <40 ms hypertrophy Contrainidicated medications in WPW NO ß-blockers; would inhibit AV node that controls rate = arrhythmia TX for WPW Procainamide Effects on afterload or preload of Handgrip increases afterload, Valsalva decreases preload, squatting increases handgrip, Valsalva, squatting preload and afterload Defect in left-right dynein results in… Dextrocardia (Kartagener SX) >QT interval increases risk for… Torsades de Pointes Congenital >QT interval causes Romano Ward (AD) and Jowell and Lange-Nielsen (AR, deafness) SCN5A mutacion Brugada syndrome Bundle of Kent Accessory conduction of WPW Sx Recombination form of BNP Nesiritide Drugs used in pharmacological stress Dipyridamole, regadenoson test Culture (-) endocarditis HACEK (Haemophilus, aggregaticobacter, cardiobacterium, eikenella, kingella), bartonella, Coxiella Hemodynamic parameter to use in HF MAP (normal 65-75), NOT BP PWP in pulmonary edema >20 mmHg Normal pressure ranges in Central venos 3-8, RV 15-30/3-8, PA 15-30/4-12, PV (wedge) 2-15, LV (100-140/3- cardiovascular system 12) CHA2DS2 Vasc CHF, Htn, Age (65-74 1 pt, >75 2 pts), diabetes, previous stroke, vascular disease, female. >1 consider anticoagulation, ≥ 2 mandatory WPW predisposes to .. AVRT Selective pulmonary vasodialtors (NOT Prostaciclins (epoprostenol, iloprost, treprostinil), nitric oxide, PDE-5 inhibitores, for left HF) endotelin antagonists (bosentan, dorusentan) Cause of redunces BNP Obesity Levosimendan Calcium sensitizer for management of acutely decompensated HF Indications for cardiac EF <35%, NHYA III-IV, maxium medical TX, QRS >120 ms (LBBB) resynchronization therapy ß-blockers used in HF Bisoprolol, metoprolol, carvedilol (alpha + beta); PX has to be euvolemic PX population for eplerenone use Diabetics or post-MI TX for pulmonar edema O2, morphine, diurectics, when systolic BP >90-100 give vasodilators (nitroglycerine, nitroprussiate), inotropic meds, aortic balloon, ß-blockers/calcium antagonists cardioversion EKG criteria ventricular Hypertrophy Tall Rs in V5-V6, deep Ss in V1-V2 (Sokolow index >35 mm, Lewis index >17 mm) Drugs contraindicated before stress ß blockers, non-DHP calcium channel blockers, amiodarone, sotalol, digoxin, tests: nitrates Meds contraindicated in vasospastic Aspirin, non-selective ß blockers, sumatriptan angina If used, Ca channel blockers in HF must ACE-inhibitors; they tend to be avoided in HF. DHF for aortic insufficiency, be used with .. verapamil/diltiazem for hypertrophic cardiomyopathy Verapamil increases toxicity for… Digoxin Trunetazidine use Protect cells from free radicals after isquemia Echo criteria for diastolic dysfunction Small E wave; EA ration ≤0.8 (normal is 0.8-2) Advantages of milrinone vs dobutamine Milrinone can be used in the presence of ß blockers but dobutamine is easier to titrate EKG if tachycardia does not come from Wide QRS SA node Meds that decrease mortality post-MI ß blockers Pericarditis EKG Global ST segmental elevation (sensitive), PR depression (specific), pericardial effusion (low voltage + electrical alternans) TX of symptomatic antidromic AVRT Procainamide IV (definitive: radiocatheter ablation) TX of symptomatic orthodromic AVRT Vagal maneuvers – AV nodal blocking agents (adenosine > verapamil). If hemodynamically unstable = cardioversion. Medication CI in WPW due to increased Digoxin risk of V fib Dopamine doses and effects Low: 0.5-2 µg/kg/min (renal + splenic vasodilation), Medium: 2-6 µg/kg/min (inotropic + cronotropic), High >10 µg/kg/min (vasoconstriction) Changes in PR interval with increased Shorter PR interval (atrial T wave can be seen after QRS altering J point = do not HR confuse with ST depression) Formulas to correct QT interval Bazetts and Hodges formulas. QRS Axis Normal: positive I and II / leftward: positive in I, negative II / rightward: negative I, positive aVF / extreme: negative I and aVF Right deviation EKG causes RV hypertrophy, RBBB left posterior fascicular block, WPW, lateral wall SX Left deviation EKG causes LV hypertrophy, LBBB, left anterior fascicular block, hyperpotasemia, inferior wal MI Possible normal negative P waves Always in aVR, sometimes III, V1 Normal QT interval <0.45 in men, <0.46 women Causes of T wave inversion Isquemia, Brugada SX, arrythmogenic, right ventricular cardiomyopathy EKG aneurysm Persisten ST elevation post MI (>3 weeks); can also be result of dyskinetic wall Causes of short QT Hypercalemia, hypercalcemia, digitalis use Tall T waves causes Hyperkalemia (>10 mm in precordial, >5 mm in limbs), early MI, LBB, LVH Prominent U waves Hypocalemia, bradycardia, intracranial hemorrhage, class 1A and 3 antiarrythmics EKF left anterior fasciscular block Left axis deviation, QRS negative II, III and aVF (r, deep S), aVL: small q, tall R AFib prophylaxis after CABG Amiodarone; it can also be used to suppress the arrhythmia TX to reduce degree of chronic cardiac Colchicine tamponade Triple anticoagulation therapy indication Only recommended for 1 month post-stent placement; then you drop aspirin and continue for a year Reverse agent dabigatran Idarucizumab EKG Mi Criteria ST elevation at J point in two contiguous leads of ≥0.1 mV in leads, EXCEPT: 1) V2-V3 ≥0.2 mV in men ≥40 years or ≥0.25 mV in <40 years or ≥0.15 in women / 2) posterior STEMI V1-V3 depression (posterior EKG would show elevation in V7-V9) KDIGO Acute Kidney Injury Criteria Increase of Cr ≥0.3 mg/dl within 48 hrs, increase CR to ≥1.5 x baseline within 7 days, urine volume <0.5 ml/kg/hr for 6 hours Shones SX Supravalvular mitral membrane (parachute mitral valve, inserted to only 1 papillary muscle) + subaortic stenosis + coarctation of the aorta Williams SX Intellectual disability / learning problmes (visual-spacial) + facial abnormalities + cardiovascular abdormalities (supravalvular aortic stenosis) Spironolactone in HF recommendation NYHA clasee II – IV + EF <35% OR PX post-STEMI with therapeutic doses of ACE inhibitors and ARBA + LVEF <40% + symptomatic HF or DM Labs contraindications for K >5.0 mEq or GFR <30 spironolactone TIMI Scores % of mortality risk at 14 days post-MI GRACE Score Estimates admission and 6 month mortality for PX w/ acute coronary syndrome Killip Class Stratify mortality post-MI first 30 days. I – no signs (6%), II – rales on crackels, S3, increased JV pressure (17%), III – acute pulmonary edema (38%), IV – cardiogenic shock or hypotension + peripheral vasoconstriction (81%) Scarbossa criteria SX MI in PX with LBBB; concordant ST elevation >1 mm in leads with positive QRS complex (5 pts) / concordant ST depression >1 mm in V1-V3 (3 pts), excessively discordant ST elevation >5 mm (25%) in leads aVR QRS complex