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CT Diagnosis of Benign Mediastinal Abnormalities: Robert
CT Diagnosis of Benign Mediastinal Abnormalities: Robert
CT Diagnosis of Benign Mediastinal Abnormalities: Robert
68
Department of Radiology, Tufts University 5
ol ofMedicine, Boston. and Boston Veterans
inistration Medical Center, 150 S. Huntington Ave.,
n, MA 02130. Address reprint re- quests to A. D. Pugatch.
CT Diagnosis of Benign The evaluation of mediastinal abnormalities is a challenging radiographic problem. Many are firs
patients who have no abnormal physical findings.
many of these individuals have undergone mediast
Mediastinal Abnormalities Cross- sectional imaging of the mediastinum by co
anatomic detail. We have analyzed the contributio
group of adult male patients.
Between September 1976 and March 1979, 49 patients at the Boston Veterans Admin- istration Medical Center were examined for mediastinal abnormalities which
were suspected
686 PUGATCH ET AL. AJR:134, April 1980
Fig. 1 -vascular vs. nonvascular mediastinal mass in asymptomatic 70-year-old patient. Posteroanterior (A) and lateral (B) chest films. Right superior mediastinal mass (arrows)
and probable aneurysm of descending aorta. Oblique radiography, fluoroscopy, and anteropos- tenor tomography failed to clarify whether retrotracheal superior
mediastinal mass was of vascular origin. C , Contrast-enhanced scan after intravenous infusion of 300 ml of Reno-M-DIP. On serial scans, mass was shown to represent
aneurysm of aberrant right subclavian artery. T his scan taken at its point of origin shows posterior tracheal (T) indentation and displacement of right mediastinal pleura laterally
(arrows). D , Cursor shows enhancing true lumen of aneurysm of descending aorta. Low density area believed to represent associated thrombosis (TH).
Of the 49 patients examined, 24 had plain chest radio- graphs that showed an
AJR:134, April 1980 CT OF BENIGN MEDIASTINAL ABNORMALITIES 687
#{188}
Fig. 2.-Diffuse mediastinal fat deposition in 58-year-old asymptomatic patient. Posteroanterior (A) and
lateral (B) films. Superior mediastinal widen- ing and suspected anterior mediastinal mass suggested
by superior medias- tinal fullness, probable paratracheal widening, and abnormal retrosternal density. C.
Superior vena cava (C) and transverse part of aortic arch (A) surrounded by excessive
homogeneous anterior mediastinal fat. Focal fat deposition also widens rightparatracheal region
(arrows). Mediastinal lipom- atosis due to obesity, exogenous steroids, or as normal variant is
easily confirmed by CT, and excludes other diagnostic considerations.
fr.
-,
A
within the anterior cardiophrenic angle. While a diagnosis of pericardial cyst or fat
pad was
T was performed to differentiate c yst from fat pad
likely in these six patients, C
seven of nine patients with a right paratracheal mass. The thoracic surgical and to exclude unusual juxtacardiac le- sions. CT findings were consistent with a
service requested CT prior to surgery to exclude a vascular abnormality. pericardial cyst or diverticulum in four patients; attenuation numbers r anged from
(However, we doubt that thoracic aortography would have been performed in the -5 to +25 Hounsfield units (H). Prone scanning showed dramatic change in the
absence of CT capability.) CT showed nonvascular masses in all seven instances. size and configuration of these abnormalities when compared with supine
In the other two patients, a vascular abnormality was predicted, but CT views, es- tablishing their cystic nature. Thoracotomy confirmed a large
demonstrated a nonvas- cular mass, thereby obviating angiography. Eight of these
pericardial cyst in one patient. (Two of these cases have been published
nine patients had metastatic mediastinal lymphadenopathy diagnosed at
previously [4].) The remaining three patients have been clinically and
mediastinoscopy and/or thoracotomy. The exception was an asymptomatic
radiographically stable for 6 months to 3 years (fig. 3). CT showed the two
30-year-old man whose right paratracheal mass was shown by CT to be enlarged,
densely calcified, azygos lymph node. The patient was subsequently diagnosed to other cardiophrenic angle lesions to be large epicardial fat pads. This was
have inactive histoplasmosis. A low kilovoltage chest film, fluoroscopy, or confirmed in one patient when exploratory thora- cotomy was performed for
conventional to- mography would probably have identified the calcifications excision of an unrelated right lower lobe hamartoma.
equally well, however. The nature of the anterior mediastinal mass was unclear in four of the
In summary, the cause of an abnormal superior medias- tinum on chest remaining five patients; three were asympto- matic and two complained of chest
radiography was correctly diagnosed prior to CT in only 13 of the 24 patients. CT pain. In the three asymp- tomatic patients, CT demonstrated focal anterior
provided specific diagnostic information not otherwise available in 1 1 of these 24 mediastinal fat deposition obviating further evaluation for suspected thymoma.
cases, and, in many, obviated thoracic angiography and probable mediastinoscopy This group included a slowly growing anterior mediastinal mass, which on review
or diagnostic thoracotomy. CT was also of value in planning surgical procedures of old films had been present for at least 4 years and probably represented a
in the eight patients who underwent operation. lipoma or thymolipoma. Conventional mediastinal tomogra- phy in the two
symptomatic patients strongly suggested a thymic lesion in one. The etiology
of the anterior mediastinal mass was unclear in the other. CT clarified the relations
of these two masses to neighboring vascular structures. CT- guided aspiration
Anterior Mediastinum
biopsy of the first lesion, which was inti- mate to the right ventricular outflow
tract, disclosed thy- moma subsequently confirmed at thoracotomy. In the
Eleven patients were examined by CT for anterior me- diastinal
abnormalities. In six, masses were contiguous to the right or left heart border sec- ond case, distortion and invasion of mediastinal and pen-
AJA:134, April 1980 CT OF BENIGN MEDIASTINAL ABNORMALITIES 689
Fig. 4.-Malignant thymoma in 52-year-old man with chest pain. A and B, Bilateral mediastinal widening and increased retrosternal density. Elevation of left diaphragm with basilar atelectasis, but
no diaphragmatic paralysis. C, Nonenhanced scan below carina. Mass widens anterior mediastinum bilaterally (arrows). D, After intravenous injection of 50 ml Aenografin 60. Mass
encompasses ascendIng aorta (AA). Residual contrast in intrapericardial part of right pulmonary artery (arrows). L ow density filling defect (arrowhead) i n superior vena cava (C) compatible
y mass. DA = descending aorta.
with intracaval tumor or thrombosis. T appearance indicates that major intrapericardial structures are Involved b
patient. An asympto- matic 26-year-old man had a round, sharply defined, middle
mediastinal mass in close proximity to the left pulmonary artery on a
screening chest film. Initial investigation with CT
cardial fat planes prompted a limited thoracotomy for tissue confirmation
excluded an abnormal pulmonary artery or an aortic lesion, obviating
of a malignant thymoma (fig. 4). angiography. The attenuation of the mass was 0- 20 H and, as predicted by both
conventional radiography and CT, a bronchogenic cyst was excised at
thoracotomy. A 30-year-old patient with dysphagia and a large subcarinal
mass on barium swallow also had right hiiar, anterior me- diastinal, and right
Middle Mediastinum paratracheal lymphadenopathy demon- strated on CT. Anteroposterior and lateral
mediastinal to- mography demonstrated only the right hilar disease. Me-
Three masses occupying the middle mediastinum were encountered. The diastinoscopy rather than thoracotomy was performed on the basis of CT
correct diagnosis based on the plain film findings was suspected in only one
findings and tuberculous mediastinitis was diagnosed. A large middle mediastinal
mass in a 73-year-
690 PUGATCH ET AL. AJR:134, April 1980
intimate to the left heart border, believed to be thymic or penicardial. The cystic nature of the mass was subsequently confirmed by ultrasound and no
treatment or further workup was pursue#{231}l.
Posterior Mediastinum
Eleven patients with masses in the posterior mediastinum were evaluated. The correct diagnosis was made in only three of these patients prior to CT.
Six cases of right paraspinal widening were examined. In two, CT was performed to further define the paraspinal component of probable osteomyelitis.
CT-guided aspiration biopsy identified Staphylococcal aureus a s the causative organism in both cases. Another patient with right panaspinal widening
was shown on CT to have azygos continuation of the inferior vena cava, subsequently confirmed by an inferior venacavogram (fig. 5). Three patients
with a localized right
D paraspinal mass had right paraspinal fat deposition dem- onstrated by CT after plain films, barium swallow, and iso- topic bone scanning failed to
establish a diagnosis.
Three patients were shown to have unusual diaphragmatic hernias, and a fourth was found to have mediastinal exten- sion of a pancreatic pseudocyst
through the esophageal- aortic hiatus. A 74-year-old patient referred for an enlarging
posterior mediastinal mass had bilateral Bochdalek hernias containing only omental fat disclosed by CT. No further evaluation was required (fig. 6).
An asymptomatic 50-year- old man with a large middle and posterior mediastinal mass had a sliding hiatal hernia on upper gastrointestinal study
AJR:134, April 1980 CT OF BENIGN MEDIASTINAL ABNORMALITIES 691
Fig. 6.-Focal fatty mediastinal masses in asymptomatic 72-year-old man referred for further evaluation
of posterior mediastinal mass. Posteroanterior (A) and lateral (B) films. Left retrocardiac mass
(arrows) b est seen on the lateral view where two smooth densities were observed ( arrowheads,
arrow) i n relation to diaphragms. Diaphragmatic-based lesion or posterior medias- t inal mass
was suspected. C, Bilateral, homogeneous, well encapsulated masses of fatty origin
(arrows) ( - 128 H) extend to right and left of spine. No other subdiaphragmatic contents were
demonstrated extending from abdo- men into t his area. Presumptive diagnosis o f bilateral
Bochdalek hernias containing only omentum was made and patient was discharged for clinical follow-up.
C = inferior vena cava; A = descending aorta.
C
A posterior superior mediastinal mass in an asymptomatic
euthyroid patient was investigated with CT to further define the anatomic
location of the lesion and to exclude the unlikely possibility of a vascular
abnormality. CT demon- strated a high density lesion continuous with an
which accounted for only one-third of his chest lesion. CT showed that the
enlarged right lobe of the thyroid. An 1311 study confirmed a medias- tinal goiter.
rest was homogeneous fat, probably her- niated omentum. In a third patient, a
CT diagnosis of me- diastinal omental herniation through the esophageal hiatus
was confirmed by surgery for unrelated peptic ulcer disease. A 46-year-old man
with acute and chronic pancreatitis had bilateral pancreatic pleural effusions Discussio
requiring chest tube drainage. Extensive evaluation for a mediastinal n
pseudocyst or a pancreaticopleural fistula including upper gastrointes-
Vascular vs. Nonvascular Masses
tinal study, ultrasound, and endoscopic retrograde cholan-
giopancreatography revealed only a 2 cm pseudocyst in the pancreatic CT offers many advantages when compared with conven- tional
body. Prior to elective surgery, CT demonstrated a large multilocular radiography in evaluating mediastinal mass lesions and focal mediastinal
pancreatic pseudocyst extending through the esophageal-aortic hiatus into widening [5-7]. Conventional radio- graphic studies are rarely diagnostic and a
the posterior me- diastinum (fig. 7). clear-cut distinc- tion among cystic, solid, vascular, or fatty lesions is often
692 PUGATCH ET AL. A JA:134, April 1980
CD
Fig. 7.-Mediastinal pseudocyst In 46-year-old man with acute pancreatitis. A, Posteroanterior film. Left pleural effusion. Thoracentesis revealed a pleural fluid amylase in excess of 50,000 Somogyl units. Similar
process developed in right pleural space after chest tube drainage on left. Diagnosis of either panCreatlCopleural fistula or mediastinal extension of pancreatic pseudocyst was considered. Upper gastrointestinal study, gray
scale ultrasound, and endoscoplc retrograde cholangiopancreatography only demonstrated 2 cm cyst in pancreatic body. B, Well demarcated pancreatic pseudocyst (arrows) behind left lobe of liver and anterior to abdominal
aorta (A). Nasogastric tube (curved arrow) a ccounts for high density within stomach. K = right kidney. C, Slightly cephalad, cyst becomes more complex (arrows), extending through thoracoabdominal junction and
displacing nasogastric-tube-containing esophagus (E) anteriorly from its usual relation to aorta (A). Smaller component of cyst is seen anteriorly on left (arrowheads). B
ilateral pleural effusions. D, lntraoperative
cystogram next morning confirms CT findings. Complex pancreatic pseudocyst ( arrows) extends into posterior mediastinum.
the extent of disease, and in some instances
obviate invasive procedures such as mediastinoscopy and thoracotomy.
Prior to thoracic CT, vessels within the mediastinum were indistinguishable
difficult. Using CT, a lesion suspected on the chest radio- graph is easily
from other structures without the use of intravenous or intraarterial contrast agents
confirmed and its relation to or origin from normal mediastinal structures
or isotopes. With 2 sec scanning, the normal great vessels are easily identified
determined. In addition, atten- uation numbers permit the identification of fatty,
vascular, and some cystic lesions. This may allow a precise diagnosis, determine
AJR:134, April 1980 CT OF BENIGN MEDIASTINAL ABNORMALITIES 693
demonstrated bilateral subpieural fat deposition and large epicardial fat
collections on their chest films and CT scans. One patient with an
in about 90% of patients because of their contrast with adjacent inhomoge- neous posterior mediastinal mass had omental herniation
mediastinal fat. Throughout the mediastinum, but especially superiorly on confirmed at thoracotomy. We believe patients with evi- dence of focal
the right, vascular causes of me- diastinal widening are frequently encountered. mediastinal or paraspinal widening should have mediastinal fat deposition
Their distinc- tion from solid neoplasms is of obvious importance [3]. Serial excluded by CT before more i nvasive procedures are performed. Thymolipomas
CT scans clearly depict the enlarged vascular struc- ture, producing a can be suggested on the basis of clinical, conventional radiologic, a nd chest
rightward or leftward displacement of the mediastinal pleura either CT findings, and dermoid tumors suspected when calcification and fat are
directly or by a shift of the superior vena cava on the right (fig. 1). When demonstrated within an anterior mediastinal mass.
necessary, rapid intravenous injection of contrast material with immediate
scanning will enhance vascular attenuation in the aorta and great vessels.
In our experience, solid thoracic or medias- tinal lesions do not enhance to a Paravertebral Widening
similar degree. Vascular enhancement after intravenous contrast injection is
Paravertebral or paraspinal widening is most frequently due to tumors of
grossly visible and attenuation determinations are usually unnec- essary. Chronic
neural origin, infection or neoplasm involv- ing the thoracic spine, paraspinal
thrombosis in association with an aneurysm is not uncommon and appears as a
lymphadenopathy, and less frequently vascular abnormalities that displace
low density area sur- rounding and paralleling the tubular course of the true
lumen. Although tumor encasing a great vessel cannot be absolutely excluded,
the over- lying pleural reflections [1 6]. CT is especially useful when an
abnormality is located at the thoracoabdominal junction. Vascular abnormalities
such a combination is exceedingly rare. If aneurysmectomy is considered,
can be easily documented with or without contrast enhancement by determining
the information pro- vided by CT may be inadequate for proper surgical vascular anatomy on serial scans (fig. 5). Herniation of intraabdom- inal fat is
planning, and appropriate angiography will be required to better vis- ualize easily diagnosed (fig. 6). Extension of pancreatic disease into the mediastinum is
the origin and course of the great vessels. Angiogra- phy should also be also visible (fig. 7).
performed in the infrequent, complex case where CT is unable to clearly Our experience with CT in detecting vertebral abnormali- ties suggests that
differentiate vascular from nonvascular lesions. plain radiographs in conjunction with nuclear scanning remain the primary
methods for accurately detecting and evaluating diseases involving the thoracic
spine, while CT is superior for imaging the paraspinal com- ponent of vertebral
disease. CT-guided aspiration biopsy at this site is justified when fluoroscopic
Cystic Masses
visualization is poor or when intimacy of a lesion to the great vessels precludes
safe fluoroscopic access.
A large number of cystic lesions has been described in the mediastinum
which may produce symptoms because of their proximity to adjacent vital
structures [8-1 0]. In this setting, CT may be performed to assist
percutaneous guided a spiration or to clarify the relations of the mass to adjacent Mediastinal Lymphadenopathy
mediastinal contents prior to thoracotomy. The radiologist should be
We believe that CT cannot distinguish benign from malig- nant
cautious in interpretation of the significance of attenuation coefficients of
mediastinal lymphadenopathy, although other associ- a ted CT findings may
mediastinal cystic lesions, since these are not diagnostic and must be
support one or the other diagnosis.
correlated with other radiographic and clinical findings. We are following
four patients with presumed cysts. These patients remain asymp- tomatic
with stable chest radiographs from 6 months to 3 years after initial
Conclusio
detection. We believe that thoracotomy may be avoided in asymptomatic
ns
patients with mediastinal cysts shown by CT.
We believe that CT should be the initial procedure in evaluating most
patients with mediastinal abnormalities on plain chest film. If the patient is
Fatty Lesions asymptomatic and the information provided by CT indicates a benign process,
conservative management with careful follow-up is justified. When a malignant
Many lesions of the mediastinum may be partially or entirely process is suspected, CT is useful in excluding vascular abnormalities, defining
composed of fat [1 1 , 1 2]. We believe that the similar CT appearance in all but the anatomic re- lationships of the lesion, and directing biopsy procedures.
one of our 16 cases including characteristic attenuation coefficients
confirms their fatty origin and correlates well with previously published findings
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