Multimedia Appendix 1.

Detailed description of the 30 Cochrane Systematic Reviews on therapeutic interventions,

used to identify relevant studies on 30 clinical questions.

N
Review status Year(Month) N (%)
Issue studies
PMID Author itle Cochrane Group (as of February content retrievable
(2010) included
2010) uptodate in Pubmed
in review
Carbamazepine versus
New search:
1 12076427 Tudur phenytoin monotherapy for Epilepsy 2 2010 (1) 10 8 (80)
no change
epilepsy
Chest physiotherapy for Acute Respiratory
2 20166082 Yang 2 New review 2009 (8) 6 5 (83)
pneumonia in adults Infections
Epinephrine injection versus
Upper
epinephrine injection and a New search:
3 17443601 Vergara Gastrointestinal 2 2009 (12) 18 15 (83)
second endoscopic method in no change
and Pancreatic
high risk bleeding ulcers
Extracranial-intracranial arterial
4 20166076 Fluri bypass surgery for occlusive Stroke 2 New review 2009 (10) 21 18 (86)
carotid artery disease
Fluticasone versus 'extrafine'
HFA-beclomethasone New search:
16625634 Lasserson Airways 2 2010 (1) 9 8 (89)
dipropionate for chronic asthma no change
5 in adults and children
Influenza vaccination for New search:
Acute Respiratory
6 20166073 Thomas healthcare workers who work 2 conclusions 2009 (9) 5 5 (100)
Infections
with the elderly changed
Mucolytic agents for chronic
New search:
7 20166060 Poole bronchitis or chronic obstructive Airways 2 2008 (10) 29 18 (62)
no change
pulmonary disease

/
 N
Review status Year(Month) N (%)
Issue studies
PMID Author Title Cochrane Group (as of February content retrievable
(2010) included
2010) uptodate in Pubmed
in review
Neuraminidase inhibitors for New search:
Acute Respiratory
8 20166059 Jefferson preventing and treating influenza 2 conclusions 2009 (8) 20 20 (100)
Infections
in healthy adults changed

van den Adenoidectomy for otitis media in Ear, Nose and

9 20091650 1 New review 2009 (10) 14 14 (100)
Aardweg children Throat

Antibiotics and antiseptics for New search:

10 20091548 O'Meara Wounds 1 2009 (11) 25 13 (52)
venous leg ulcers no change

Metabolic and
Antithyroid drug regimen for New search:
11 20091544 Abraham Endocrine 1 2009 (4) 27 23 (85)
treating Graves' hyperthyroidism no change
Disorders

Artesunate versus quinine for Infectious New search:no

12 17943870 Jones 1 2007 (6) 6 4 (67)
treating severe malaria Diseases change

Bed rest for acute uncomplicated New search:

13 17443530 Herkner Heart 1 2009 (10) 17 11 (65)
myocardial infarction no change
Benzodiazepines for the relief of
Pain, Palliative
breathlessness in advanced
14 20091630 Simon and Supportive 1 New review 2009 (9) 7 4 (57)
malignant and non-malignant
Care
diseases in adults
Blood pressure lowering efficacy
15 20091622 Chen of beta-blockers as second-line Hypertension 1 New review 2009 (11) 20 11 (55)
therapy for primary hypertension
Blood pressure lowering efficacy
of potassium-sparing diuretics
16 20091662 Heran (that block the epithelial sodium Hypertension 1 New review 2009 (10) 8 7 (88)
channel) for primary
hypertension

/
 N
Review status Year(Month) N (%)
Issue studies
PMID Author Title Cochrane Group (as of February content retrievable
(2010) included
2010) uptodate in Pubmed
in review

New search:
17 20091514 Welsh Caffeine for asthma Airways 1 2009 (8) 7 7 (100)
no change

Continuous subcutaneous insulin

infusion (CSII) versus multiple Metabolic and
18 20091571 Misso 1 New review 2009 (7) 34 27 (79)
insulin injections for type 1 Endocrine
diabetes mellitus
Effect of cyclosporine on blood
19 20091657 Robert Hypertension 1 New review 2009 (6) 17 17 (100)
pressure
Upper New search:
Enteral versus parenteral
20 20091534 Al-Omran Gastrointestinal 1 conclusions 2009 (10) 8 8 (100)
nutrition for acute pancreatitis
and Pancreatic changed
Exercises for prevention of
21 20091596 Choi Back 1 New review 2009 (7) 13 13 (100)
recurrences of low-back pain
Home-based versus centre-
22 20091618 Taylor Rod Heart 1 New review 2008 (7) 22 17 (77)
based cardiac rehabilitation
Immediate-release versus
controlled-release
23 20091617 Powell Epilepsy 1 New review 2009 (11) 10 10 (100)
carbamazepine in the treatment
of epilepsy
Proton pump inhibitor treatment
Upper
initiated prior to endoscopic New search:
24 17054257 Sreedharan Gastrointestinal 1 2009 (8) 6 3 (50)
diagnosis in upper no change
and Pancreatic
gastrointestinal bleeding
Inflammatory
Rectal 5-aminosalicylic acid for
Bowel Disease
25 20091560 Marshall induction of remission in 1 New review 2008 (12) 38 33 (87)
and Functional
ulcerative colitis
Bowel
Regular treatment with
New search:
26 18646149 Cates salmeterol for chronic asthma: Airways 1 2009 (8) 49 30 (61)
no change
serious adverse events

/
 N
Review status Year(Month) N (%)
Issue studies
PMID Author Title Cochrane Group (as of February content retrievable
(2010) included
2010) uptodate in Pubmed
in review
Rifabutin for treating pulmonary Infectious New search:
27 17943842 Davies 1 2007 (7) 5 4(80)
tuberculosis Diseases no change
Serotonin receptor antagonists Pain, Palliative
28 20091591 Billio for highly emetogenic and Supportive 1 New review 2009 (3) 16 15(94)
chemotherapy in adults Care
Short-term treatment with proton
pump inhibitors, H2-receptor
antagonists and prokinetics for Upper
van New search:
29 16855986 gastro-oesophageal reflux Gastrointestinal 1 2009 (10) 45 38 (80)
Pinxteren no change
disease-like symptoms and and Pancreatic
endoscopy negative reflux
disease
New search:
Therapeutic ultrasound for
30 20091539 Rutjes Musculoskeletal 1 conclusions 2009 (7) 5 5 (100)
osteoarthritis of the knee or hip
changed