Date: 19-03-2020

Spring Vacation Assignment no. 3

Topic: Heme and Porphyria
By: Dr. Taha A. Khan

MCQS
1. Acute intermittent porphyria (paraoxymal porphyria) is caused due to
deficiency of
(A) Uroporphyrinogen I synthase
(B) ALA synthase
(C) Coproporphyrinogen oxidase
(D) Uroporphyrinogen decarboxylase
2. The major symptom of acute intermittent porphyria includes
(A) Abdominal pain
(B) Photosensitivity
(C) No neuropsychiatric signs
(D) Dermatitis
3. The characteristic urinary finding in acute intermittent porphyria is
(A) Increased quantity of uroporphyrin
(B) Increased quantity of coproporphyrin I
(C) Increased quantity of coproporphyrin III
(D) Massive quantities of porphobilinogen
4. The enzyme involved in congenial erythropoietic porphyria is
(A) Uroporphyrinogen I synthase
(B) Uroporphyrinogen III cosynthase
(C) Protoporphyrinogen oxidase
(D) Ferrochelatase
5. Main symptoms of congenital erythropoietic porphyria is
(A) Yellowish teeth (B) Photosensitivity
(C) Abdominal pain (D) Brownish urine

VIVA QUESTION
1. The probable cause of porphyria cutanea tarda is deficiency of ?
2. The characteristic urinary finding in porphyria cutanea tarda is ?
3. Hereditary coproporphyria is caused due to deficiency of ?
4. The enzyme involved in variegate porphyria is ?
5. Protoporphyria (erythrohepatic) is characterized by the deficiency of ?

KEY
MCQS:
1. A Lippincott. 6E. p 280
2. A Lippincott. 6E. p 281
3. D Lippincott. 6E. p 281
4. B Lippincott. 6E. p 282
5. B Lippincott. 6E. p 283
VIVA QUESTIONS:
1. Uroporphyrinogen oxidase Lippincott. 6E. p282
2. Increased quantity of uroporphyrin Lippincott. 6E. p282
3. Coproporphyrinogen oxidase Lippincott. 6E. p283
4. Protoporphyrinogen oxidase Lippincott. 6E. p 82
5. Ferrochelatase Lippincott. 6E p283