Date: 02-04-2020

Spring Vacation Assignment no. 14

Topic: Xenobiotics
By: Dr. Taha A. Khan

MCQS
Q-1. Which of the following is not Phase-I reaction
a) Oxidation
b) Reduction
c) Hydrolysis
d) Conjugation
Q-2. The main enzyme responsible for activation of xenobiotics is
a) Cytochrome P-450
b) Glutathione S-transferase
c) NADPH cytochrome P-450-reductase
d) Glucuronyl transferase
Q-3. All are true about glutathione except
a) It converts hemoglobin to methemoglobin
b) It scavenges free radicals and superoxide ions
c) It is tri-peptides
d) It conjugates xenobiotics
Q-4. What is metabolized like xenobiotics?
a) Myoglobin
b) Bilirubin
c) Biliverdin
d) Hemoglobin
52. Many xenobiotics
(A) Increase hepatic ALA synthase
(B) Decrease hepatic ALA sythase
(C) Increase hepatic ALA dehydrase
(D) Decrease hepatic ALA dehydrase

VIVA QUESTION
Q-1. Which of the following enzymes are associated with breakdown of H2O2?
Q-2. H2O2 is beaked and formed by which of the following enzyme?
Q-3. Bile salts undergo xenobiotics after?
Q-4. The conjugation of bilirubin to glucuronic acid in the liverresults in?
Q-5. ω-oxidation takes place by the hydroxylase in microsomes involving?

KEY
MCQS:
1. D Harper 30E 585
2. A Harper 30E 585
3. A Harper 30E 585
4. B Harper 30E 585
5. A Harper 30E 585
VIVA QUESTIONS:
1. Catalase, Peroxidase Harper 30E 587
2. Catalase Oxidase Peroxidase Harper 30E 587
3. After conjugation with beta glucuronic acid. Harper 30E 585
4. Converts a hydrophobic compound to a hydrophilic one Harper 30E 586
5. Cytochrome p-450 Harper 30E 584