Date: 31-03-2020

Spring Vacation Assignment no. 12

Topic: Nucleotide metabolism
By: Dr. Taha A. Khan

MCQS
1. Histamine is formed from histidine by the enzyme histidine decarboxylase in
the presence of
(A) NAD (B) FMN
(C) HS-CoA (D) B6-PO4
2. Infantile convulsions due to lesser formation of gamma amino butyric acid
from glutamic acid is seen in the deficiency of
(A) Glutamate-dehydrogenase
(B) Pyridoxine
(C) Folic acid
(D) Thiamin
3. Which of the following amino acids produce a vasoconstrictor on
decarboxylation?
(A) Histidine (B) Tyrosine
(C) Threonine (D) Arginine
4. The degradation of RNA by pancreatic ribonuclease produces
(A) Nucleoside 2-Phosphates
(B) Nucleoside 5′-phosphates
(C) Oligonucleosides
(D) Nucleoside 3′-phosphate and oligonucleotide
5. Intestinal nucleosidases act on nucleosides and produce
(A) Purine base only (B) Phosphate only
(C) Sugar only (D) Purine or pyrimidine
bases and sugar

VIVA QUESTION
1. Phosphorylation of adenosine to AMP is catalysed by?
2. The major determinant of the overall rate of denovo purine nucleotide
biosynthesis
is the concentration of?
3. In the biosynthesis of purine nucleotides the AMP feed back regulates?
4. UDP and UTP are formed by phosphorylation from?
5. Reduction of ribonucleotide diphosphates (NDPs) to their corresponding
deoxy
ribonucleotide diphosphates (dNDPs) involves?

KEY
MCQS:
1. D Lippincott. 6E. p 287
2. B Lippincott. 6E. p 373
3. B Lippincott. 6E. p 267
4. D Lippincott. 6E. p 397
5. D Lippincott. 6E. p 299
VIVA QUESTIONS:
1. Adenosine kinase Lippincott. 6E. p 296
2. 5-phosphoribosyl 1-pyrophosphate Lippincott. 6E. p 294
3. Adenylosuccinate synthetase Lippincott. 6E. p 295
4. ATP Lippincott. 6E. p 142
5. NADPH Lippincott. 6E. p 293