Date: 28-03-2020

Spring Vacation Assignment no. 10

Topic: Lipid metabolism
By: Dr. Taha A. Khan

MCQS
1. De novo synthesis and oxidation of fatty acids differ in the following
respect:
(A) Synthesis occurs in cytosol and oxidation in mitochondria
(B) Synthesis is decreased and oxidation increased by insulin
(C) NADH is required in synthesis and FAD in oxidation
(D) Malonyl CoA is formed during oxidation but not during synthesis
2. Free fatty acids released from adipose tissue are transported in blood by
(A) Albumin (B) VLDL
(C) LDL (D) HDL
3. -Galactosidase is deficient in
(A) Fabry’s disease
(B) Krabbe’s disease
(C) Gaucher’s disease
(D) Metachromatic leukodystrophy
4. The enzyme deficient in metachromatic leukodystrophy is
(A) Arylsulphatase A (B) Hexosaminidase A
(C) Ceramidase (D) Sphingomyelinase
5. All of the following statements about generalized gangliosidosis are true
except
(A) It results from deficiency of GM1-- Gangliosidase
(B) Breakdown of GM1 ganglioside is impaired
(C) GM2 ganglioside accumulates in liver and elsewhere
(D) It leads to mental retardation

VIVA QUESTION
1. Hexosaminidase A is deficient in
2. Mental retardation occurs in
3. The enzyme deficient in Fabry’s disease is
4. Biosynthesis of Triglyceride and Lecithine both require an intermediate:
5. The rage limiting step cholesterol biosynthesis is

KEY
MCQS:
1. A Lippincott. 6E. p 212
2. A Lippincott. 6E. p 212
3. B Lippincott. 6E. p 213
4. A Lippincott. 6E. p 210
5. C Lippincott. 6E. p 212
VIVA QUESTIONS:
1. Tay-Sachs disease Lippincott. 6E. p 212
2. Tay-Sachs disease, Gaucher’s disease, Niemann-Pick disease Lippincott. 6E. p 212
3. Alpha Galactosidase Lippincott. 6E. p 212
4. Phosphatidic acid Lippincott. 6E. p 212
5. HMG CoA reductase Lippincott. 6E. p 221