Add 2 numbers:

data segment
a dw 0202h
b dw 0408h
c dw ?
data ends
 
code segment
assume cs:code,ds:data
start:
mov ax,data
mov ds,ax
mov ax,a
mov bx,b
add ax,bx
mov c,ax
int 3
code ends
end start

Subtract 2 numbers:
data segment
a dw 9A88h
b dw 8765h
c dw ?
data ends
 
code segment
assume cs:code,ds:data
start:
mov ax,data
mov ds,ax
mov ax,a
mov bx,b
sub ax,bx
mov c,ax
int 3
code ends
end start

Multiple two numbers:

data segment
a dw 1234h
b dw 5678h
c dd ?
data ends

code segment
assume ds:data, cs:code
start:
mov ax,data
mov ds,ax
mov ax,a
mov bx,b
mul bx
mov word ptr c,ax
mov word ptr c+2,dx
int 3
code ends
end start