The Williamson ether synthesis

Introduction;
In the previous laboratory experiment a variety of substitution reaction were carried out
in order to qualitatively assess the rates of substitution with a variety of substrates.
Previously you should have found that SN2 reaction work best with strong nucleophile
and primary or methyl halides the SN2 reaction is an important reaction for bond
formation in both organic and biological chemistry, in this example you will first
generate a moderate a strong nucleophile by deprotonating of 2 nepthol with sodium
hydro oxide .
A substitution reaction occurring between an oxygen nucleophile and an organohalide
Williamson was awarded a Royal Medal 1862. Founded in 1825 by King George, this
award is given annually by the royal society for the most important contribution in the
physical, biological and applied sciences.

Chemical Required:
o 2-nephthanol 15 mg
o 1-brembutane
o NaOH 87 mg
o Etoit 25 ml
Material Required:
o Conical flask
o Stand
o Condenser
o Aluminum Block

Procedure:
o Measured out 150 mg of 2-naphtnol and added thos solid to a 5ml conical flask.
o Added 2.5ml of ethanol and commencing stirring ,then add 87mg of crushed
solid NaOH
o Secure reaction with aluminum black and it temperature should be above of 78 c
to archive a good reflex
o After 10 minutes reflex allowed the solution to cool at least 60c and then
temperature remove the sir condenser and add 0.15ml of 1-bomobitane
o Reattached the air condenser and reheated the reaction to reflex for 15 minutes
o Removed vial from heat and allowed it cool at least 50C
o Transferred the content of reaction into a flask and add 3.4 chunks of ice followed
by 1---->2ml ice cold water.
 o Dried the solid for 5-- 10 minutes determined the yield and melting point of
the product

Results:
Ether linkage accrued by Williamson synthesis and their conformation take place by
fruity smell and is melting point is 49C