COAGULATON FACTOR

FACTOR SOURCE PATHWAY DESCRIPTION FUNCTION

I fibrinogen Liver Common Plasma Glycoprotein Adhesive protein which

340 kDa aids in fibrin clot
formation

II Prothrombin Liver common Vit K dependent; serine Presence in the activated

protease; 72 kDa form and main enzyme of
coag

III Tissue Secreted by damaged Extrinsic & Intrinsic Known as lipoprotein initiator of
factor/thromboplastin cells and platelets thromboplastin; extrinsic pathway
37 kDa

IV Calcium Bone and Gut Entire process Require for coag factors Metal cation which is
to bind to phospholipid; important in coag
mechanism

V Labile Factor/ Liver and platelet Intrinsic and Extrinsic 330 kDa Cofactor for the
Proaccelerin activation of prothrombin
to thrombin
(prothrombinase
complex)

VI

VII Stable factor/ Platelet and endothelium Extrinsic Vit K dependent serine With tissue factor,
proconvertin protease; initiates extrinsic
50 kDa pathway (F IX & X)

VIII liver Intrinsic 330 kDa Cofactor for intrinsic

Antihemophilic Factor activation of factor X
(which is form tenase
complex)

IX Plasma liver Intrinsic Vit K dependent; serine Activated form is the

Thromboplastin protease; 50 kDa enzyme for intrinsic
Component/ christmas activator of factor X
factor (forms tenase complex
with factor VIII)

X Stuart Prower Factor
liver Intrinsic and Extrinsic Vit K dependent serine Activated form is the
protease; 58.9 kDA enzyme for final common
pathway of prothrombin
(forms prothrombinase
complex with factor V)

XI Plasma liver Intrinsic 160 kDa; serine protease Activates intrinsic

Thromboplastin activator of factor IX
Antecedent

XII Hageman Factor/ liver Intrinsic (activates 80 kDa; serine protease Initiates activated partial
Glass Factor plasmin) thromboplastin time
(aPTT) based intrinsic
pathway; activates factor
XI, VII and Prekellikrein

XIII Fibrin-stabilizing liver Retards fibrinolysis 320 kDa; Cross-link Transamidase which
Factor fibrin cross-links fibrin clot

Summary of Coagulation Factors

 factors explanation

Contact group PK, HMWK, XII, XI Factors involved in initiation of

intrinsic pathway

Prothrombin group II, VII, IX, X Vitamin K–dependent factors.

Fibrinogen group I, V, VIII, XIII Factors acted on by thrombin (V,

VIII, & XIII are activated; I is
converted to fibrin). All are high
molecular weight proteins.

Factors in extrinsic pathway TF, VII

Factors in intrinsic pathway PK, HMWK, XII, XI, IX, VIII

Factors in common pathway X, V, II, I

Extrinsic tenase complex VIIa/TF Acts on X.

Intrinsic tenase complex IXa/VIIIa Acts on X.

Prothrombinase complex Xa/Va Acts on prothrombin

Factor VIII complex VIII:C & von Willebrand factor VIII:C is the procoagulant; VWF
(VWF) is the carrier protein

Produced in liver All

Require vitamin K for II, VII, IX, X

synthesis

Affected by Coumadin II, VII, IX, X All that require vitamin K.

(warfarin) Warfarin is a vitamin K
antagonist.

Consumed during clotting I, II, V, VIII, XIII Not present in serum.

Labile factors V, VIII