Haptoglobin Ceruloplasmin A2-macroglobin Transferrin (siderophilin)

Increased Increased
Inflammation Inflammation Liver dse Iron deficiency anemia
Ulcerative colitis Tissuge damage Diabetes Heridetary dis.
Acute rheumatic dse Severe infection Contraceptives Hemochromatosis
Heart attack Cancers Pregancy
Severe infection Pregnacy Nephrosis
Nephrotic syndrome Estrogen oral contraceptives
Burn Medications

Decreased
Hemolytic anemia Malnutrition Liver dse
Malabsorption Malnutrition
Severe liver dse Protein losing disoders:
Nephrotic syndrome Nephrotic syndrome
Menkes syndrome(kinky hair) Infection
Dxn Malignancy
Hemolytic anemia anemia
- Wilson's dse-decreased level InflAmmation
Kayser fleischer rings-cu cornea
PREALBUMIN ALBUMIN AAT AFP
Increased
Ptn takng steroids Dehydration CIRRCHOSIS Spina bifida
Alcoholism Excess albumin infusion Inflammation rxns Neural tube defects
Chronic renal failure Pregnacy Abdominal cellwall defect
Contraceptive use Anencephaly
Gen fetal distress

Decreased
Malnutrition

Poor nutritional status Down syndrome

Hepatic damage Malabsorption Trisomy 18
APIR Liver dse Twins
TISSUE NECROSIS Mtutation causing analbumenia & bisalbuminemia
Renal dse
Protein losing entropathy
Burns & excessive administration of iv fluids
Redistribution of hemodilution:
^ capillary permiability
Dec. Lymph clearance
OROSOMUCOID/ AAG AAC

Stress MUTAIONS:
Trauma Parkensons dse
Inflammation Alzheimers dse
Tissue damage
Acute myocardial infarction
Trauma
Pregnacy
Cancer
Pnuemonia

Rheumatoid arthritis
Surgery