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    Biofarmasetika 1

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    Dewa Ayu Pradnya Dewi
    1. The document contains pharmacokinetic data for an antibiotic and a pain medication, including elimination rate constant (Ke), half-life (T1/2), and volume of distribution (Vd). 2. The elimination rate constant and half-life for the antibiotic were 0.19 hr-1 and 3.67 hrs respectively, while the values for the pain medication were higher at 0.68 hr-1 and 1.02 hrs. 3. The volume of distribution was much larger for the antibiotic at 75.53 L compared to 5.77 L for the pain medication, indicating a higher concentration of the pain medication in the body.

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    Biofarmasetika 1

    Uploaded by

    Dewa Ayu Pradnya Dewi
    15 views8 pages
    1. The document contains pharmacokinetic data for an antibiotic and a pain medication, including elimination rate constant (Ke), half-life (T1/2), and volume of distribution (Vd). 2. The elimination rate constant and half-life for the antibiotic were 0.19 hr-1 and 3.67 hrs respectively, while the values for the pain medication were higher at 0.68 hr-1 and 1.02 hrs. 3. The volume of distribution was much larger for the antibiotic at 75.53 L compared to 5.77 L for the pain medication, indicating a higher concentration of the pain medication in the body.

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    biofarmasetika

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    1. The document contains pharmacokinetic data for an antibiotic and a pain medication, including elimination rate constant (Ke), half-life (T1/2), and volume of distribution (Vd). 2. The elimination rate constant and half-life for the antibiotic were 0.19 hr-1 and 3.67 hrs respectively, while the values for the pain medication were higher at 0.68 hr-1 and 1.02 hrs. 3. The volume of distribution was much larger for the antibiotic at 75.53 L compared to 5.77 L for the pain medication, indicating a higher concentration of the pain medication in the body.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    15 views8 pages

    Biofarmasetika 1

    Uploaded by

    Dewa Ayu Pradnya Dewi
    1. The document contains pharmacokinetic data for an antibiotic and a pain medication, including elimination rate constant (Ke), half-life (T1/2), and volume of distribution (Vd). 2. The elimination rate constant and half-life for the antibiotic were 0.19 hr-1 and 3.67 hrs respectively, while the values for the pain medication were higher at 0.68 hr-1 and 1.02 hrs. 3. The volume of distribution was much larger for the antibiotic at 75.53 L compared to 5.77 L for the pain medication, indicating a higher concentration of the pain medication in the body.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    of 8

    t (jam) Cp (mcg/ml) AUC

    0.5 19.3 9.2175


    1 17.57 13.072
    1.8 15.11 27.61
    4 9.99 15.408
    5.8 7.13 13.024
    8 4.71 13.86
    12 2.22 8.817
    18 0.719 2.847
    24 0.23 1.216931
    Total: 105.0724

    No Persamaan Farmakokinetika Hasil Satuan


    1 Ke 0.189 jam-1
    2 T 1/2 3.6674454 jam
    3 AUC 105.0724 mg.jam/L
    4 Clearens 14.275870733 L/jam
    5 Vd 75.533707582 L
    100

    10

    Column B

    0.1
    0 5 10 15 20 25 30
    2.5

    f(x) = 21.4720878130758 exp( − 0.188931930495261 x )


    2 R² = 0.99999005950837

    1.5
    Column B
    Column B Exponential (Column B)
    1

    0.5

    0
    30 10 12 14 16 18 20 22 24 26
    t(jam) Cp(mg/L) Cp terminal(mg/L) Cp residual(mg/L) AUC(mg.jam/L)
    0 54.05 8.993 45.057 2.1265
    0.05 31.01 8.69368149563042 22.3163185043696 1.262
    0.1 19.47 8.40432535833056 11.0656746416694 0.827
    0.15 13.61 8.12460000566839 5.48539999433161 0.605
    0.2 10.59 0.48875
    0.25 8.96 0.42475
    0.3 8.03 0.387
    0.35 7.45 0.36225
    0.4 7.04 0.34425
    0.45 6.73 0.33
    0.5 6.47 0.3175
    0.55 6.23 0.30575
    0.6 6 0.29525
    0.65 5.81 0.2855
    0.7 5.61 0.27575
    0.75 5.42 0.2665
    0.8 5.24 0.2575
    0.85 5.06 0.24875
    0.9 4.89 0.2405
    0.95 4.73 0.2325
    1 4.57 6.7503692762186
    Total 16.633369276219

    NO Parameter Hasil Satuan


    1 Ke 0.677 jam-1
    2 T 1/2 1.02385107911366 jam
    3 AUC 16.63336928 mg.jam/L
    4 Clearens 3.90780718601349 L/jam
    5 Vd 5.77224104285596 L
    100 5

    4.9
    f(x) = 8.993436
    R² = 0.9999046
    4.8

    10 4.7
    Column B

    4.6

    4.5

    1 4.4
    0 0.2 0.4 0.6 0.8 1 1.2 0.88 0.9 0.92 0.94

    50
    45
    f(x) = 45.0441856956927 exp( − 14.0379705120165 x )
    40 R² = 0.99999988491665

    35
    30
    25 Column D
    Exponential (Column D)
    20
    15
    10
    5
    0
    0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16
    5

    4.9
    f(x) = 8.99343625995805 exp( − 0.676790985806672 x )
    R² = 0.999904619250431
    4.8

    4.7 Column B
    Exponential (Column B)
    4.6

    4.5

    4.4
    0.88 0.9 0.92 0.94 0.96 0.98 1 1.02
    PENENTUAN PARAMETER FARMAKOKINETIKA ANTIBIOTIK

    Obat/Parameter Ke (jam-1) T 1/2 (jam) Vd (L)


    Antibiotika 0.19 3.67 75.53
    Anti Nyeri 0.68 1.02 5.77

    N.B : Buat Laporan hasil perbandingan


    Jika Cl nya tinggi, laju obatnya cepat.
    Volume distribusi tinggi, konsentrasi obat dalam tubuh kecil
    TIKA ANTIBIOTIK

    D (mg) AUC (mg.jam/L) Cl (L/jam)


    1500 105.07 14.28
    65 16.63 3.91

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