NCM 106 PHARMACOLOGY

STUDY GUIDE
1. ANTINEOPLASTIC ANTIBIOTICS iii. Pulmonary toxicity + inhibit cell growth and
a) ACTION: break up DNA links and interstitial pneumonitis division.
prevent DNA synthesis by inserting iv. Hepatic/Renal toxicity ii. Epidermal Growth Factor
themselves between base pairs, g) SAMPLE MEDS: v. Alopecia Inhibitor via Erlotinib for fast
causing a mutation that leads to cell i. Busulfan vi. Necrosis and cellulitis growing cells.
death ii. Carboplatin e) NOTES: iii. Proteasome inhibitor
b) INDICATION: neoplasms i. kill cells during the M phase b) INDICATION: chronic myelocytic
c) C/I: 3. ANTI-METABOLITES ii. Extravasation could be a huge leukemia and multiple myeloma
i. pregnancy + lactation a) ACTION: inhibit DNA production in problem c) C/I:
ii. allergy cells that depend on certain natural f) SAMPLE MEDS: end in -axel or -oside i. pregnancy + lactation
iii. bone marrow suppression metabolites to produce their DNA i. Docetaxel ii. allergy
iv. renal/hepatic dysfunction b) INDICATIONS:Leukemias, GI and ii. Etoposide iii. pts with arrhythmia
v. Bleomycin + mitomycin → basal cell cancers d) ADVERSE EFFECTS:
pulmonary problems c) C/I: 5. HORMONE SITE SPECIFIC i. Imatinib → GI upset
vi. idarubicin → cardiac problems i. pregnancy + lactation a) ACTION: block the release of ii. the side effects that occur in
d) ADVERSE EFFECTS: ii. allergy gonadotropin hormones in the others do not appear here
i. hematological effects iii. bone marrow suppression breast/prostate cancer if the tumors e) ADVERSE REACTIONS:
ii. CNS effects iv. renal/hepatic dysfunction are responsive to those hormones. i. Hepatotoxicity
iii. Pulmonary toxicity + v. GI ulceration may also block.interfere with ii. CNS: confusion, abnormal
interstitial pneumonitis d) ADVERSE REACTIONS: receptor site. thinking, uncontrolled
iv. Hepatic/renal toxicity i. Leucovorin b) INDICATION: breast cancer and emotions
v. Alopecia ii. Hematological effects prostatic cancer iii. Telithromycin (Ketek) causes
e) NOTES: iii. CNS effects c) C/I: px to have difficulty focusing
i. Toxic to rapidly dividing cells iv. Pulmonary toxicity + i. pregnancy + lactation and accommodating to light
ii. Affect S phase interstitial pneumonitis ii. allergy f) NOTE:
f) SAMPLE MEDS: ending in -mycin or v. Renal/Hepatic toxicity iii. bone marrow suppression i. attack cancer cells not healthy
-rubucin vi. Alopecia iv. renal/hepatic dysfunction cells
i. Bleomycin e) NOTES: v. GI ulcerations ii. results in fewer toxic effects
ii. Doxorubicin i. inhibit dna production by vi. Toremifene → hypercalcemia g) SAMPLE MEDS:
inhibiting metabolites needed d) ADVERSE REACTIONS: i. Bortezomib
2. ALKYLATING AGENTS for dna synthesis of dna in i. Menopause associated effects ii. Imatinib
a) ACTION: inhibit susceptible cells ii. Increase in risk for
b) ACTION: disrupts cellular ii. S-phase specific cardiovascular disease 7. MISC. ANTINEOPLASTICS
mechanisms that affect DNA, RNA f) SAMPLE MEDS: some end in -bine iii. Abiraterone → increase risk of a) ACTIONS: cause cell death
and other cellular proteins that lead i. Cladribine adrenocortical insuff b) INDICATION: neoplasms
to cell death ii. Cytarabine iv. Increased/Decreased effects c) C/I:
c) INDICATION: lymphomas, leukemia, of the hormones on the body i. pregnancy + lactation
myelomas, ovarian, breast and 4. MITOTIC INHIBITOR → Virilization ii. allergy
testicular cancer, and pancreatic a) ACTION: interfere with the ability of e) NOTES: d) ADVERSE REACTIONS:
cancer the cell to divide i. Hormones and hormonal i. Hematological effects
d) C/I: b) INDICATIONS: tumors, and agents are used to treat ii. CNS effects
i. pregnancy + lactation leukemias specific cancers that respond iii. Hepatic/Renal toxicity
ii. allergy c) C/I: to hormone stimulation, like iv. Alopecia
iii. bone marrow suppression i. pregnancy + lactation breast and prostate cancer v. Necrosis + cellulitis
iv. renal/hepatic dysfunction ii. allergy f) SAMPLE MEDS:
e) ADVERSE EFFECTS: iii. bone marrow suppression i. Anastrozole e) SAMPLE MEDS:
i. Hematological effects iv. renal/hepatic dysfunction ii. Flutamide i. Belinostat
ii. GI effects v. GI ulcerations ii. Talc powder
iii. Hepatic/Renal toxicity vi. Eribulin → arrhythmia due to 6. CANCER CELL SPECIFIC
iv. Alopecia prolonging QT a) ACTION:
f) NOTES: d) ADVERSE REACTIONS: i. act on specific enzymes
i. Cell-cycle non specific i. Hematological effects needed for protein building by
ii. Most effective against slow- ii. CNS effects specific tumor cells, which
growing tumors