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How To Make LSD Acid
How To Make LSD Acid
How To Make LSD Acid
com/forum/topic/273528-how-to-make-acid-im-not-asking-i-have-
the-answer/
MAKING LSD
------ ---
ITEMS NEEDED:
----- ------
1-About 200-250 grams of MORNING GLORY SEEDS or BAY HAWAIIAN WOOD ROSE
SEEDS. The Morning Glory seeds can be obtained at most plant nurseries.
=========================================================================
2. In 145 cc. of petroleum ether, soak the seeds for two or three days.
3. With screen, filter the liquid thru it and save the seed mush and
allow it to dry completely.
5. Filter solution again only. Save the liquid in a large glass jar.
6. Soak the seed mush again in 130 cc. of wood alcohol for two more days.
7. Filter out the mush and keep the liquid. Now, get the liquid that was
saved in step 5.
9. When all the liquid has dried, a yellowish gummy looking substance will
appear on the cookie sheet.
10. Take the yellow gum and put this into capsules.
=========================================================================
You can get the capsules just by buying something like DEXITRIM or some
other pill. Even CONTACT comes in jel capsules. Just empty them out and
put the yellow gum in the capsules. Allow the capsules to sit over night
for best results.
****************************************
* THUNDER GOD *
* GLADLY PRESENTS *
* *
* LSD *
* TAKEN FROM *
* THE ANARCHIST COOKBOOK *
* BY *
* WILLIAM POWELL *
****************************************
----------------------------------------
LSD
I THINK, OF ALL THE DRUGS ON THE BLACK
MARKET TODAY, LSD IS THE MOST INTER-
ESTING AND THE STRANGEST. IT IS THE MOST
RECENT MAJOR DRUG TO COME TO LIFE IN THE
PSYCHEDELIC SUBCULTURE. HUXLEY EXPERIMEN
TED WITH MESCALINE MANY YEARS BEFORE
PSYCHEDELICS REACHED THEIR MASS-MARKET
PROPORTIONS,BUT THIS EXPERIMENTATION
WAS NOT WITH THE SAME FRAME OF MIND AS
THESE DRUGS ARE HANDLED TODAY. PROBABLY
THE GREAT-GRANDDADDY TO THE WHOLE
PSYCHEDELIC COMMUNITY WAS ANTONIN ARTAUD
, WHO PERSONALLY EXPERIMANTED WITH
PEYOTE IN MEXICO. THE DIFFERENCE BETWEEN
HUXLEY'S AND ARTAUD'S EXPERIMENTATION
WAS THAT HUXLEY MANAGED TO KEEP HIS
EXPERIENCES UNDER LABATORY CONTROL,
WHICH HE SET UP HIMSELF,WHEREAS ARTAUD
ALLOWED HIS EXPERIENCES TO BECOME PART
OF HIS LIFE. ARTAUD WAS CHANGED BY HIS
ENCOUNTERS WITH PEYOTE, WAS THIS BAD?
A DIRTY SHIRT IS ALSO CHANGED WHEN
IT IS WASHED. THROUGH THIS CHANGE ARTAUD
WAS ABLE TO SEE AND UNDERSTAND IDEAS
AND CONCEPTS ON A DIFFERENT LEVEL.
HE WAS ABLE TO TEAR APART
RATIONALIZATIONS, WITH OUT REGAURD FOR
CONTEMPORARY METHODS OF ORGANIZATION,
OR EVEN CONTEMPORARY VERSIONS OF TRUTH.
ARTAUD FOUND,IN HIS OWN WAY,HIS OWN
TRUTHS AND HIS OWN STRUCTURES OF VALUE.
THEY LOCKED HIM UP...
----------------------------------------
SINCE MOST OF US CANT GET ACCESS TO A
LAB I WILL GO RIGHT TO THE SECTION ON
MAKIND LSD IN YOU KITCHIN,
----------------------------------------
MAKING LSD IN YOU KITCHIN
1. GRIND UP 150 GRAMS OF MORNING GLORY
SEEDS OR BABY HAWAIIAN WOOD ROSE
SEEDS.
DOSAGES
PRAGMATICS
----------
SET and SETTING (how to have a good time; lsd ain't beer)
STORAGE (keep in a cool dark dry place)
SYNERGIES, BAD COMBINATIONS (cannabis is good, otherwise be careful)
******************************
LSD
Generic name for the hallucinogen lysergic acid
diethylamide-25. Discovered by Dr. Albert Hofmann in 1938, LSD is one
of the most potent mind-altering chemicals known. A white, odorless
powder usually taken orally, its effects are highly variable and begin
within one hour and generally last 8-12 hours, gradually tapering off.
It has been used experimentally in the treatment of alcoholics and
psychiatric patients. [Where it showed some success.] It
significantly alters perception, mood, and
psychological processes, and can impair motor coordination and skills.
During the 1950s and early 1960s, LSD experimentation was legally
conducted by psychiatrists and others in the health and mental health
professions. Sometimes dramatic, unpleasant psychological reactions
occur, including panic, great confusion, and anxiety. Strongly
affected by SET and SETTING. Classification: hallucinogens. Slang
names: acid, sugar. See also appendix B. (RIS 27:211-52 entries)
..............................
Common Drug Slang Terms (NB: many of these refer to the carrier, ie, "Blotter"
or "Sugar Cubes". Often the local names will refer to patterns printed
on the blotter, eg, "Blue unicorn".):
Acid, 'Cid, Sid, Bart Simpsons, Barrels, Tabs, Blotter, Heavenly blue,
"L", Liquid, Liquid A, Lucy in the sky with diamonds, Microdots,
Mind detergent, Orange cubes, Orange micro, Owsley, Hits,
Paper acid, Sacrament, Sandoz, Sugar, Sugar lumps,
Sunshine, Tabs, Ticket, Twenty-five, Wedding bells, Windowpane,
etc.
..............................
PROPERTIES
METHOD OF ADMINISTRATION
PRECAUTIONS
ANTIDOTE
9792*-Z1540 e.-sp./d.-fr.
Printed in Switzerland.
..............................
Peripheral Actions
..............................
******************************
ADDICTION POTENTIAL:
Zero physical addiction potential. Not something that makes you want to
do it again immediately. Rarely people use it to escape in a negative
way or as part of "polydrug abuse" behavior or pattern of behavior.
******************************
ADULTERANTS:
..............................
..............................
Note that: 1) on a piece of paper, vs. a tablet, you can't even add
significant amounts of adulterants 2) adulterants would cost, whereas
blank paper will rip someone off just as well.
LSD itself has some "body-kinks" on some people some times. nausea is
one of them. its usually mild and transient. it also has speedlike
(ie, adrenergic stimulation) effects, etc.
..............................
Actually, I think the fact that PharmChem analyzed something on the order of
2,000 LSD samples between 1972 and 1979 and never found one with strychnine
in it would be better. I'm going over all their data with a toothpick and
I'll get back to you on exactly what I find. It looks like the percent of
LSD with strychnine in it is, however, at least under .05%. More a little
later.
..............................
Summary of Street Drug Results - 1973: "Of 189 samples of LSD quantitatively
analyzed, the average dose was 67.25ug LSD. Of the 32 samples of alleged
mescaline actually containing mescaline, [...stuff about mescaline and
mushrooms deleted...] It is interesting to note the low incidence of
deception among the less sought after psychotomimetics LSD and PCP."
..............................
This is the PharmChem analysis of LSD from 1972 (vol 1, no 1) up to the time
that the DEA no longer allowed them to make quantitative measurements (1974-
vol 3, no 2 included). NOTE: NO STRYCHNINE! also note that PharmChem found
a sample of Shrooms contaminated with Strychnine in 1972 (vol 1, no 7), and
I would think it safe to assume that they also checked LSD for Strychnine.
******************************
BAD TRIPS:
MYTHS:
LSD does not form "crystals" that reside in the body to be "dislodged"
later, causing flashbacks. LSD is a crystalline solid (though it is
unlikely that one would ever have enough to be visible to the naked
eye) but it is easily water soluble, thus cannot form bodily
deposits. Furthermore, it is metabolized and excreted in hours. The
bogus "loosened crystal" description in not necessary to explain
flashbacks, which are psychological phenomena (see FLASHBACKS).
In Science 30 April 1972, Volume 172 Number 3982 p. 431-440 there was an
article by Norman I. Dishotsky, William D. Loughman, Robert E. Mogar and
Wendell R. Lipscomb titled "LSD and Genetic Damage - Is LSD chromosome
damaging, carcinogenic, mutagenic, or teratogenic?". They reviewed 68
studies and case reports published 1967-1972, concluding "From our own
work and from a review of literature, we believe that pure LSD ingested
in moderate doses does not damage chromosomes in vivo, does not cause
detectable genetic damage, and is not a teratogen or carcinogen in man."
Well, there's the study by Sidney Cohen which was cited here
recently, Journal of Nervous and Mental Disease, 130, 1960. The
following is from Jay Stevens' Storming Heaven: "Cohen surveyed a sample
of five thousand individuals who had taken LSD twenty-five thousand
times. He found and average of 1.8 psychotic episodes per thousand
ingestions, 1.2 attempted suicides, and 0.4 completed suicides.
'Considering the enormous scope of the psychic responses it induces,'
he concluded, 'LSD is an astonishingly safe drug.'"
Some urban legends: I've heard two "stories" about people blinding
themselves on "drugs". One was revealed as a hoax by the person who
perpetrated it (apparently it was intended to "illustrate" the dangers
of LSD), another is trotted out by anti-drug speakers at high schools:
1) Seven people on LSD stared at the sun and lost 90% of their reading
vision.
While these are bogus, the drug has powerful effects on the mind
and the consumer should be aware of the hazards, and act appropriately.
..............................
..............................
DANGERS:
..............................
..............................
The reported LD50 values for LSD are 46, 16.5, 0.3 mg/kg I.V. for mice,
rats, and rabbits, respectively. Again, it's hard to accurately translate
these numbers to oral values.
Note that an average human dose is 0.001 mg/kg, ie, 1 microgram/kg, ie,
1 part per billion by weight.
..............................
******************************
FLASHBACKS:
******************************
INSOMNIA:
******************************
TOLERANCE:
******************************
BOTANY:
..............................
..............................
******************************
ANTHROPOLOGY:
The thin book contains their argument for the use of the ergot fungus
in Eleusian rites, Wasson providing some background on the use of
mushrooms and grains and their role in the culture; Hoffman on the
psychoactivity of ergot strains; and Ruck on the mythological and
cultural backround of the sect.
An interesting read, and its neat to think that the culture that
more or less lead to the western industrial one had psychedelic rites.
(Various greek prominant figures attended the rituals, including Plato).
..............................
In 1955 Osmond described personal experiments with Rivea corymbosa seeds and
reported that the effects were similar to those of d-lysergic acid
diethylamide (LSD-25). He suggested (1957) that the word psychedelic (meaning
mind-manifesting) be used as a generic term for this class of substances to
refer to their consciousness-expanding and psychotherapeutic function as
contrasted with the hallucinogenic aspect. In 1960 Hoffman reported that he
had isolated d-lysergic acid amide (LA) and d-isolysergic acid amide from the
seed of both Rivea corymbosa and Ipomoea violacea. LA is very similar to LSD
in its psychological and physiological manifestations but is reported to have
about one twentieth the psychological effectiveness of LSD (Cerletti &
Doepfner, 1958).
The effects of the seeds of Ipomoea purpurea (varieties Heavenly Blue and
Pearly Gates) in a total of 45 cases are summarized below. The subjects are
all normally functioning adults and the majority had previous experience with
LSD. The onset of effects is about half an hour after the seeds have been
chewed and swallowed and they last from five to eight hours.
This dosage rarely produces any visual distortions, although with eyes
closed there may be beginning imagery. Restlessness, evidenced by alternating
periods of pacing about and lying down, may be present. There tends to be a
heightened awareness of objects and of nature, and enhanced rapport with
other persons. A feeling of emotional clarity and of relaxation is likely to
persist for several hours after other effects are no longer noticeable.
In this range the effects resemble those reported for medium-dose (75-150
micrograms) LSD experiences, including spatial distortions, visual and
auditory hallucinations, intense imagery with eyes closed, synaesthesia and
mood elevation. These effects, which occur mainly during the period of 1 to 4
hours after ingestion, are typically followed by a period of alert calmness
which may last until the subject goes to sleep.
In this range the first few hours may resemble the medium-dose effects
described above. However, there is usually a period during which the
subjective states are of a sort not describable in terms of images or
distortions, states characterized by loss of ego boundaries coupled with
feelings of euphoria and philosophical insight. These seem to parallel the
published descriptions of experiences with high doses (200-500 micrograms) of
LSD given in a supportive, therapeutic setting as reported by Sherwood et al.
(1962).
All the subjects who had previous experience with LSD claimed the effects of
the seeds were similar to those of LSD. Transient nausea was the most
commonly reported side effect, beginning about one half hour after ingestion
and lasting a few minutes to several hours. Other reported side effects not
commonly found with LSD were a drowsiness or torpor (possibly due to a
glucoside also present in the seeds) and a coldness in the extremities
suggesting that the ergine content of the seeds may be causing some vascular
constriction. (If this is the case, there may be some danger of ergot
poisoning resulting from excessive dosages of the seeds.) The only untoward
psychic effect was a prolonged (eight hours) disassociative reaction which
was terminate with chlorpromazine [Thorazine]. The possibility of prolonged
adverse reactions to the psychological effects of the seeds is essentially
the same as with LSD, and the same precautions should be observed (Cohen &
Ditman, 1963).
..............................
IPOMOEA.003 7-MAY-90
Additional Notes:
Ipomoea purpurea is sold as the "Heavenly Blue" variety of morning glory.
"Ipomoea tricolor" is the trade name used for that variety. It is identical
with the species of morning glory described above.
Unpleasant LSD and morning glory trips can be smoothed out or even
stopped by taking niacin (in the form of nicotinic acid, vitamin B-3 or
"niacin"). Vitamin C has been shown to reduce the incidence of paranoia and
prevent depletion of the vitamin from the adrenal glands during LSD trips.
The last few notes about Niacin and Vitamin C are based on
a paperback edition of Hoffer & Osmonds "The Psychedelics"
It's pretty clear that the latin names of this plant are somewhat
confused (which is typical). Ipomoea purpurea, Ipomoea tricolor,
Ipomoea violacea and Ipomoea rubro-caerulea are all the same plant.
..............................
Hylin and Watson found the major alkaloidal constituents in A. nervosa seeds to
be ergine (780 mcg/g of fresh seed) and isoergine and penniclavine (555 mcg).
******************************
CHEMISTRY:
Only one stereoisomer (the d-) is psychoactive. Thus, racemic (l/d 50-50 mix)
lsd shows half the potency of the dextro form. In synthesis it is possible
to recover the l-form for the lysergic acid.
Lysergic Acid Diethylamide is LSD rather than LAD because the German word
for acid is saeure (sp).
O CH2-CH3 O
|| / ||
|| / ||
-C--N C---OH
| \ |
| \ |
|___ CH2-CH3 |___
/ \ /
/ \ /
<< N---CH3 << N---CH3
\ / \ /
\____/ \____/
/ \ /
/ \ /
< > < >
// \ / // \ /
// \_____/ // \_____/
| || || | || ||
| || || | || ||
| || || | || ||
\ /\ / \ /\ /
\ / \ / \ / \ /
N N
H H
******************************
MECHANISM OF ACTION:
..............................
..............................
>"If there's no documentation, you can't tell bugs from features." ---C.P.
******************************
RELATED COMPOUNDS:
LSD's two ethyl groups hanging off the amine may be replaced with
other carbon chains for compounds with different durations, potencies,
and effects.
..............................
..............................
DMT
CH
/ 3
// \--- --- CH CH N
|| || || 2 2
\ //\ / CH
N 3
H
******************************
MANUFACTURE:
Forget it. Precursors (ergot alkaloids, used medicinally for migraines and
ob/gyn due to their vasoconstrictive effects) are closely watched. (They
are obtained through commercially cultured ergot fungus; one could
theoretically extract lsyergic amides from morning glory or Hawaiian wood
rose seeds.) (Though there are routes to synthesize lysergic acid from
"scratch", these are complicated also.) Other typically needed chemicals
are very dangerous. Serious experience in organic chemistry lab would be
necessary. If you have to ask where to find the recipes, you don't know
enough about chemistry to try it. (For the curious: the _Anarchists
Cookbook_ is a bad place to start. _Psychedelic Chemistry_ is better, the
patent office or chem. lit. better.) And you'll probably trip during
manufacture if you actually succeed. Its easier and safer to buy it on the
black market.
******************************
DRUG TESTING:
..............................
Second of all, LSD and its metabolites are detectable in the urine
for much longer than one hour.
"LSD and its metabolites were still detectable in human urine for
as long as 4 days after the ingestion of 0.2 mg of the drug.
[Faed, E.M., McLeod, W.R.: A urine screening test of lysergide.
Journal of Chromatographic Science. 11, 4-6 (1973)]
Note that standard, cheap initial drug screening does not use
chromatography or mass-spectrometry, and does not look for LSD.
..............................
You might want to mention that Abbie Hoffman's _Steal This Urine Test_
has a table which claims lsd is detectable for 40 days. I'm almost sure
this was a typo.
..............................
This varies by the test being used, the detection limit placed on the test,
the point of collection and type of the sample fluid, the amount of LSD that
was taken, and the individual in question.
Assuming the testers are using an RIA screening test with the cutoff set at
0.1 ng/ml and assuming that the user has recently emptied their bladder,
then the detection limit for one hit (100 ug) is normally around 30 hours.
Each doubling of the initial amount will add about 5 hours. Thus taking 8
hits will leave a user vulnerable for approximately 2 days. (NOTE: This is
based on the data in [7])
> 2] What exact form of test can be used to detect LSD in the body? There
are a number of tests which can be used to detect LSD in the body.
Both EMIT and Abuscreen are "positive/negative" response tests (much like
pregnancy tests) which require periodic equipment calibration and consume
chemicals for each test performed. A basic battery of tests costs approx.
$15-$25 per person [4]. The basic tests (recommended by NIDA) include
marijuana, cocaine, amphetamines, opiates, and phencyclidine (PCP).
Normally, unless an (employer) specifically requests the test, an LSD assay
is not run.
Positive results to either EMIT and RIA are held to be "probable cause" by
U.S. courts. GC/MS results are held to be "proof" by U.S. courts.
> I am asking for an actual text message containing a short, precise >
description of each test,
I would suggest you read the article posted by Paul Hager paying particular
attention to the warning about water intoxication [12]:
In <1991May7.141615.16477@news.cs.indiana.edu> hagerp@iuvax.cs.indiana.edu wrote
+ Recommended: "Dealing With Urine Tests on Short Notice"
+ by Dale Gieringer, California NORML
+
+ Most folks recommend that people hydrate themselves -- the idea
+ being that by drinking water and taking a diuretic that will
+ promote water loss, the urine will be very dilute and THC metabolite
+ content from "tomatoe" consumption will drop below the 100 ng/ml
+ threshold that defines a "positive".
+
+ Mr. Gieringer recommends that, the day before the test, the
+ person drink lots of water. I would amend this to, drink your
+ normal "8 glasses" plus a few more. Don't get carried away with
+ drinking water -- there is such a thing as "water intoxication"
+ which can result in brain swelling and other nasties so don't
+ chug-a-lug a gallon of water just before the test. After
+ hydrating, and a little before the test, drink some more water
+ and use a diuretic (coffee is a weak diuretic). Urinate to
+ flush the bladder -- the first urination of the day is the
+ one most charged with metabolites. The pamphlet quotes from
+ a _High Times_ article, "How to Beat a Drug Test":
+
+ Take an 80 mg dose of the prescription diuretic Lasix
+ (furosemide); take a hefty drink of water; piss two
+ or three times; then take the test.
+
+ Some caution is to be exercised in taking diuretics. Consult
+ your physician.
+
+ Mr. Gieringer also suggests that the clear, watery urine that
+ results from the above procedure is sometimes suspicious. He
+ recommends taking 50-100 mg of vitamin B2 which will color
+ urine yellow for a couple of hours. Vitamin C does not produce
+ this effect -- contrary to rumor.
+
+ For more information, I'd suggest contacting California NORML
+ directly at (415) 563-5858. They are located in San Francisco.
+ It is also possible that Mr. Gieringer will respond directly
+ via his canorml account.
> I am asking for ...[a description]... of each thing that LSD leaves behind
> that can be detected, and of each method used to beat each test.
FOOTNOTES:
[1]
Altunkaya, D; Smith R.N.
"Evaluation of a commercial radioimmunoassay kit for the detection of
lysergide (LSD) in serum, whole blood, urine, and stomach contents"
Forensic Science International. v47n2, September 1990, p113-21.
[2]
Taunton-Rigby, A.; Sher, S.E.; Kelley, P.R.
"Lysergic Acid Diethylamide: Radioimmunoassay"
Science. v181, July 13 1973, p165-6.
[3]
McCarron, M.M.; Walberg, C.B.; Baselt, R.C.
"Confirmation of LSD intoxication by analysis of serum and urine."
Journal of Analytical Toxicology. v14n3, May-June 1990, p165-7.
[4]
Berg, E.
"Drug-testing methods: what you should know."
Safety & Health. v142n6, Dec 1990, p52-6.
[5]
Lim, H.K.; Andrenyak, D.; Francom, P.; Bridges, R.R.; Foltz, R.L.
"Determination of LSD in urine by capillary column gas chromatography
and electron impact mass spectrometry."
Journal of Analytical Toxicology. v12n1, Jan-Feb 1988, p1-8.
[6]
Lim, H.K.; Andrenyak, D.; Francom, P.
"Quantification of LSD and N-demethyl-LSD in urine by gas chromatography/
resonance electron capture ionization mass spectrometry."
Analytical Chemistry. v60, July 15 1988, p1420-25.
[7]
Papac, D.I.; Foltz, R.L.
"Measurement of lysergic acid dietylamide (LSD) in human plasma by gas
chromatography/negative ion chemical ionization mass spectrometry."
Journal of Analytical Toxicology. v14n3, May-June 1990, p189-90.
[8]
Paul, B.D.; Mitchell J.M.; Burbage, R.; Moy, M; Sroka, R.
"Gas chromatographic-electron-impact mass fragmentometric determination
of lysergic acid diethylamide in urine."
Journal of Chromatography. v529n1, July 13, 1990, p103-12.
[9]
Blum, L.M.; Carenzo, E.F.; Rieders, F.
"Determination of lysergic acid diethylamide (LSD) in urine by instrumental
high-performance thin-layer chromatography."
Journal of Analytical Toxicology. v14n5, Sep-Oct 1990, p285-7.
[10]
Ratcliffe, W.A.; Fletcher, S.M.; Moffat, A.C.; et. al.
"Radioimmunoassay of Lysergic Acid Diethylamide (LSD) in serum and urine
by using antisera of different specificities."
Clinical Chemistry. v23n2, Feb 1977, p169-74.
[11]
Cody, J.T.; Schwarzhoff, R.H.
"Impact of adulterants on RIA analysis of urine for drugs of abuse."
Journal of Analytical Toxicology. v13n5, Sep-Oct 1989, p277-84.
[12]
Klonoff, D.C.
"Acute water intoxication as a complication of urine drug testing in the
workplace."
Journal of the American Medical Association. v265n1, Jan 2 1991, p84-6.
[13]
Christie J.; White, M.W.; Wiles, J.M.
"A chromatographic method for the detection of LSD in biological liquids."
Journal of Chromatography. v120n2, May 26, 1976, p496-501.
[14]
Twitchet, P.J.; Fletcher, S.M.; Sullivan, A.T.; Moffat, A.C.
"Analysis of LSD in human body fluids by high-performance liquid chromatography,
fluorescence spectroscopy and radioimmunoassay."
J. Chromatogr. v150n1, March 11 1978, p73-84.
..............................
IDNUM 03319915
TYPE Journal paper
DATE 880715
AUTHOR Heng Keang Lim; Andrenyak, D.; Francom, P.; Foltz, R.L.; Jones, R.T.
Center for Human Toxicology, Utah Univ., Salt Lake City, UT, USA
TITLE Quantification of LSD and N-demethyl-LSD in urine by gas
chromatography/resonance electron capture ionization mass
spectrometry
SOURCE Analytical Chemistry; vol.60, no.14; 15 July 1988; pp. 1420-5
SUBJECT chromatography; electron capture; mass spectroscopic chemical
analysis; organic compounds; quantification; gas chromatography;
resonance electron capture ionisation mass spectrometry; LSD;
N-demethyl-LSD; urine; lysergic acid diethylamide; human; in vitro;
in vivo; aromatic hydroxylation; drug; metabolite;
N-tri-fluoroacetyl derivatives; calibration curves; urinary
concentrations; adult volunteer; excretion; elimination half-lives;
4 to 6 hrs; 8 to 10 hrs
Numerical data: time 1.4E+04 to 2.2E+04 s; time 2.9E+04 to 3.6E+04 s
Class codes: A8280M; A8280B; A3470
CODEN ANCHAM
ABSTRACT Demethylation of lysergic acid diethylamide (LSD) in the human has
been demonstrated, both in vitro and in vivo, and aromatic
hydroxylation at positions 13 and 14 has been tentatively
identified. A gas chromatography/resonance electron capture
ionization mass spectrometry (GC/MS) assay for LSD and
N-demethyl-LSD in urine has been developed, in which the drug and
its metabolite are converted to their N-tri-fluoroacetyl derivatives
prior to GC/MS analysis. Linear and reproducible calibration curves
have been obtained for LSD concentrations from 0.05 to 5.0 ng/mL,
and for N-demethyl-LSD concentrations from 0.03 to 5.0 ng/mL. The
assay was used to determine the urinary concentrations of LSD and
N-demethyl-LSD following administration of a single oral dose of the
drug (1 mu g/kg) to an adult volunteer. The rates of excretion of
LSD and N-demethyl-LSD reached maxima in urine collected at time
intervals of 4-6 and 8-10 h after administration, respectively. The
elimination half-lives for LSD and N-demethyl-LSD were 3.6 and 10.0
h, respectively
MISCELLANEOUS
Treatment: experimental
Anal. Chem. (USA)
Abstract number(s): A89037987
ISSN: 0003-2700
Refs: 15
******************************
LEGAL SCHEDULING:
Class I, "no medical use" --- mostly for political reasons, as it was
and is used in psychotherapy. (Current use is in Switzerland.)
******************************
******************************
STORAGE:
******************************
Alcohol's effects are largely overwhelmed by LSD, and they act in opposite
ways: alcohol being a depressant and LSD being a (hyper)stimulant.
Generally mixing stimulants and sedatives is counterproductive.
******************************
SYNTHESIS:
Don't try it, too difficult and risky both physically and
legally. Precursor medical drugs (ob/gyn and migraine ergot
alkaloids) are watched.
******************************
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