Ethan Vinodh

IR I/10 CC/1st
April 29, 2020

Meta-Cognitive Analysis Results

Year Study Method Citation Results

Sample

Study 1 2014 20 male Randomized Fetoni, Anna R et al. Curcumin treatment

adult Clinical Trial “Curcuma longa
Wistar (curcumin) decreases in
rats vivo cisplatin-induced
ototoxicity through heme
oxygenase-1 induction.”
Otology & neurotology:
official publication of the
American Otological
Society, American
Neurotology Society [and]
European Academy of
Otology and Neurotology
vol. 35,5 (2014): e169-77.
doi:10.1097/MAO.000000
0000000302
attenuated hearing loss
induced by cisplatin,
increased OHC survival,
decreased 4-HNE
expression, and increased
HO-1 expression. This
preclinical study
demonstrates that
systemic curcumin
attenuates ototoxicity and
provides molecular
evidence for a role of
HO-1 as an additional
mediator in attenuating
cisplatin-induced damage.

Study 2 2016 70 Double-Blind Rahimi, Hamid Reza et al. Mean age, BMI, FBG,
type-2 Randomized “The effect of total cholesterol (TC),
diabetes Clinical Trial nano-curcumin on HbA1c, triglyceride (TG), LDL,
patients fasting blood glucose, and HDL, HbA1c, and sex
lipid profile in diabetic and had no significant
subjects: a randomized difference at the baseline
clinical trial.” ​Avicenna between the groups. In
journal of phytomedicine the Nano-curcumin
vol. 6,5 (2016): 567-577. group, a significant
decrease was found in
HbA1C, FBG, TG, and
BMI comparing results of
each subject before and
after the treatment
(p<0.05). By comparing
pre- and post-treatment

Study 3 2015 30 OSF Randomized Hazarey, Vinay K et al.
patients Clinical Trial “Efficacy of curcumin in
the treatment for oral
submucous fibrosis - A
randomized clinical trial.”
Journal of oral and
maxillofacial pathology:
JOMFP​ vol. 19,2 (2015):
145-52.
doi:10.4103/0973-029X.1
64524
values among the groups,
HbA1c, eAG, LDL-C,
and BMI variables
showed significant
differences (p<0.05).
These findings suggest an
HbA1c lowering effect
for Nano-curcumin in
type-2 diabetes; also, it is
partially decreasing in
serum LDL-C and BMI.
The test group showed a
5.93 (±2.37) mm increase
in mouth opening
compared to 2.66 (±1.76)
mm of the control group.
In relation to the VAS
scale with spicy and
normal food, the average
reduction was 64 (42-73)
and 77 (70.5-82) as
compared to 34
(14.5-64.5) and 64
(46-75.5) respectively in
the control group. The
test group results
achieved in the treatment
span were sustained in the
follow-up (P < 0.05)
compared to the control
group which showed
statistically significant (P
< 0.05) relapse. It can be
concluded that
combination strategies for
the management of OSF
which include the
stoppage of causative ill
habits, appropriate
medicinal, and
physiotherapy
management is more
efficient than single
 therapeutic modality. It is
evident from the study
that curcumin holds good
promise in the treatment
of OSF in the future.

Study 4 2013 30 Double-Blind Ryan, Julie L et al. Standard pooled variances

Breast Randomized “Curcumin for radiation
Cancer Clinical Trial dermatitis: a randomized,
Patients double-blind,
placebo-controlled clinical
trial of thirty breast cancer
patients.” ​Radiation
research​ vol. 180,1
(2013): 34-43.
doi:10.1667/RR3255.1
t-test showed that
curcumin reduced RDS at
end of treatment
compared to placebo
(mean RDS = 2.6 vs. 3.4;
P = 0.008). Fisher's exact
test revealed that fewer
curcumin-treated patients
had moist desquamation
(28.6% vs. 87.5%; P =
0.002). No significant
differences were observed
between arms for
demographics,
compliance, radiation
skin dose, redness, pain,
or symptoms. In
conclusion, oral
curcumin, 6.0 g daily
during radiotherapy,
reduced the severity of
radiation dermatitis in
breast cancer patients.

Study 5 2015 45 Single-Blind Paschoal, Marco Aurélio No significant difference

Adolesce Randomized et al. “Longitudinal effect
nt Clinical trial of
Orthodo curcumin-photodynamic
ntic antimicrobial
Patients chemotherapy in
adolescents during fixed
orthodontic treatment: a
single-blind randomized
clinical trial study.”
Lasers in medical science
vol. 30,8 (2015): 2059-65.
was found to PI between
the groups during the
baseline and 1-month
period. Group III (1.52 ±
0.51) presented a
significance difference
from the group I (0.91 ±
0.75) and group II (1.03 ±
0.51) at 3 months of
follow-up. In this same
period, there was more
doi:10.1007/s10103-014-1 plaque accumulation with
700-7 a significant statistical
difference (P ≤ 0.05) in
comparison to the other
periods to all studied
groups. There was a GBI
reduction statistically
significant to groups I and
III at a 1-month follow-up
in comparison to other
periods. No effect was
verified to dental plaque
accumulation after the
photodynamic application
mediated with curcumin
activated with a blue LED
light.