1) The oral cavity and face develop between 3-12 weeks of gestation through the proliferation and division of processes from the frontonasal prominence and branchial arches.
2) During the 3rd week, rapid cell proliferation occurs in the frontonasal process. Between the 4th-5th week, the medial nasal process divides and forms the globular process.
3) Abnormalities of facial development can result in featureless faces, cleft lips and palates, abnormally small or large mouths and tongues, and other structural defects due to failures of fusion or improper arrangement of facial prominences and processes during early development.
1) The oral cavity and face develop between 3-12 weeks of gestation through the proliferation and division of processes from the frontonasal prominence and branchial arches.
2) During the 3rd week, rapid cell proliferation occurs in the frontonasal process. Between the 4th-5th week, the medial nasal process divides and forms the globular process.
3) Abnormalities of facial development can result in featureless faces, cleft lips and palates, abnormally small or large mouths and tongues, and other structural defects due to failures of fusion or improper arrangement of facial prominences and processes during early development.
1) The oral cavity and face develop between 3-12 weeks of gestation through the proliferation and division of processes from the frontonasal prominence and branchial arches.
2) During the 3rd week, rapid cell proliferation occurs in the frontonasal process. Between the 4th-5th week, the medial nasal process divides and forms the globular process.
3) Abnormalities of facial development can result in featureless faces, cleft lips and palates, abnormally small or large mouths and tongues, and other structural defects due to failures of fusion or improper arrangement of facial prominences and processes during early development.
DEVELOPMENT OF THE ORAL CAVITY AND THE FACE 4th week – 6.5mm ; division of one medial process & two lateral process ; - Brain develop first formation of nasal placode. LAW OF UNEQUAL GROWTH 5th week – 9-9.2 mm ; medial nasal - Applies in the developing embryo process will grow downward creating - Not all cells of the developing globular process. embryo grows at the same time. 6th week – nasolacrimal groove PRIMITIVE ORAL CAVITY (between lateral nasal & maxillary prominence) ; eyes are on the lateral - Bay-like depression side of the face. - Forms when the head stoops/bend down 7th week – 14.5 mm ; eyes move anteriorly ECTODERM 8th week – 10th week –lidless eyes -grows faster 12th week –facial derivatives -top most layer Neuralation – folding of embryo -lining/epithelium Amniotic fluid – protection for fetus MESENCHYME Corion – placental – respiratory (lungs) -supporting tissue for developing embryo Ectomesodermal origin – where tooth arises from -primitive connective tissue Enamel – only calcified tissue that is BRANCHIAL ARCHES ectodermal , others are mesodermal; calcium phosphate MANDIBULAR ARCH – biggest/ give rise to the maxillary ABNORMALITIES OF THE FACE
PHARYNGEAL ARCHES CONTAIN: Aprosopus – featureless face
MAJOR ARTERY – blood supply Upturned Nostril – wrongly arrange of
CRANIAL NERVE – nerve supply nose PRECARTILAGINIOUS – bone / Hypertelorism – Borad median nasal skull & face process Cheiloschisis – Cleft Lip
Uranoschisis – Cleft Hard Palate
Gnathoschisis – Failure of fusion
mandibular process
Staphyloschisis – Cleft Soft Palate
Microstomia – abnormally small mouth
Macrostomia –big mouth
Astomia – absence of mouth
Microglossia – abnormally small tongue
Ankyloglossia – the tongue tied down on
the floor of the mouth.
Snake Tongue – failure of fusion of the
lateral process
Hemifacial Microstomia – 3rd most
common malformation
Treacher’s Collin Syndrome – inherited
disorder that results from the action of dominant gene