TUTORIAL answer scheme

QUESTION 1

In Drosophila melanogaster, red eyes (re+) and long wings (lw+) are dominant to white eyes
and miniature wings. The re+ lw+ / re+ lw+ is mated with re lw / re lw producing a F1 that
show all dominant characteristics.

a) Show the genetic diagram of the cross.

(3 Marks)

P: re+ lw+ re lw
X
re+ lw+ re lw

F1: re+ lw+

re lw

b) The F1 are testcrossed. The following result are obtained.

Phenotypes Number of offspring

Red eyes, long wings 650

White eyes, miniature wings 618

Red eyes, miniature wings 284

White eyes, long wings 260

i) Show the diagram of the testcross

(3 Marks)

re+ lw+ x re lw

re lw re lw

G: re+ lw+ re lw re+ lw re lw+ re lw

Offspring: re+ lw+ re lw re+ lw re lw+

 re lw re lw re lw re lw

ii) Calculate the map distance between re and lw.

(2 Marks)

Map distance = number of recombinants x 100

Total number of offspring

= 284 + 260 x 100

650 + 618 + 284 + 260

= 544 x 100
1812

= 30 cM

2. Sex-linked traits are genetic characteristics determined by genes located on sex

chromosomes. Hemophilia is a bleeding disorder that slows the blood clotting process
and it is sex linked recessive. Sarah is a carrier for hemophilia married to Ryan who is
hemophiliac.

i) Show the genotype and phenotype of their children.

(3 Marks)

P: XHXh x XhY

XH Xh Xh Y

XHXh XHY XhXh XhY

Daughter, Son, Daughter, Son,
Normal Normal Hemophiliac Hemophiliac

ii) Give the percentage getting hemophiliac daughter.

(1 Mark)

50%
 iii) State the probability getting three normal sons.
(2 Marks)

½ x ½ x ½ = 1/8

QUESTION 3

a) A segment of human DNA has the following sequence of nucleotide.

5’ – GCCTAATGGCCTTTACCGCCTTGG – 3’

i) Write the complementary DNA strand.

(2 Marks)

3’ – CGGATTACCGGAAATGGCGGAACC – 5’
ii) Write the mRNA strand.
(2 Marks)

5’ – GCCUAAUGGCCUUUACCGCCUUGG – 3’

iii) Write the amino acid sequence.

(2 Marks)

Ala – stop – Trp – Pro – Leu – Pro – Pro - Trp