Neck of Femur Fracture Who Gets A Total Hip Replacement A Review

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European Journal of Trauma and Emergency Surgery

https://doi.org/10.1007/s00068-020-01358-5

ORIGINAL ARTICLE

Neck of femur fracture: who gets a total hip replacement? A review


of 230 eligible patients
Atanu Bhattacharjee1,6 · Owen Richards2 · Chris Marusza3 · Claire J. Topliss4 · Ian Wilson5 · Stephen Phillips5 ·
Ian Starks5

Received: 29 November 2019 / Accepted: 30 March 2020


© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Abstract
Purpose  To investigate patient-specific factors that predict Total Hip Replacement (THR) in patients with fracture neck of
femur (NOF), fulfilling the National Institute of Health and Care Excellence (NICE) criteria.
Methods  Hip fracture database from a district general hospital and university hospital was retrospectively reviewed to
identify patients fulfilling NICE criteria for THR after fracture NOF. Patient demographics, Nottingham Hip Fracture score
(NHFS), complications, re-operations, revision, 30 days and one-year mortality was obtained from patient-records. Inde-
pendent predictors correlating with the outcome of surgery were identified. A logistic regression analysis was used to predict
the type of surgery in these patients.
Results  A total of 230 (114 WMH and 116 MH) were identified; 133 (57.8 per-cent) received hip hemiarthroplasty (HA), and
97 (42.2 per-cent) received THR. Patients receiving THR (mean 73.5 years, 95% CI 72–74.8) were significantly younger in
comparison to patients receiving HA (mean 81.7 years, 95% CI 80.5–82.8). A negative correlation is noted between NHFS
and type of surgery (Pearson’s correlation − 0.537, p < 0.01), implying higher NHFS decreased the likelihood of receiving
THR. Regression analysis showed NHFS (p-0.001) and walking ability (p-0.001) as significant predictors for the type of
surgery (Nagelkerke R2-0.472). A log-rank test showed higher estimated survival time in patients with THR in comparison
to HA (p-value 0.002).
Conclusions  NHFS and walking ability can be used as an adjunct to the NICE criteria for selecting patients for THR after
fracture NOF. Carefully selected patients treated with THR survive longer and have a better outcome in comparison to HA.

Keywords  Hip fracture · Total hip replacement · Neck of femur fracture · Nottingham hip fracture score (NHFS)

Introduction

NICE first published clinical guidance on hip fracture man-


* Atanu Bhattacharjee agement in June 2011. They recommended that patients with
atanu_bhattacharjee@yahoo.co.in a displaced intra-capsular neck of femur fracture (NOF)
should be offered a total hip replacement (THR) [1] if they
1
Speciality Trainee, Orthopaedics, Morriston Hospital, Wales fulfilled the following criteria:
Deanery, Swansea SA6 6NL, UK
2
Orthopaedic Registrar, Wrexham Maeloar Hospital, • were able to walk independently outdoors with no more
Wrexham LL13 7TD, UK
than the use of a stick and
3
Core Trainee, Morriston Hospital, Wales Deanery, • are not cognitively impaired and
Swansea SA6 6NL, UK
• are medically fit for anaesthesia and the procedure.
4
Consultant Orthopaedics Surgeon, Morriston Hospital,
Swansea SA6 6NL, UK
A recent review of these guidelines in 2017 reaffirmed the
5
Consultant Orthopaedics Surgeon, Wrexham Maeloar same indications for consideration of THR after NOF [1].
Hospital, Wrexham LL13 7TD, UK
This has led to the paradigm shift of ‘offering THR rather
6
Speciality Trainee, Orthopaedics, Wrexham Maeloar than HA’ in patients fulfilling the above criteria [1, 2].
Hospital, Wrexham LL13 7TD, UK

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A. Bhattacharjee et al.

The NICE guidelines are based upon a growing body Methods


of evidence demonstrating that fit and active patients
with a fracture NOF achieve a better functional outcome Patient data were retrieved from the Hip Fracture Database
with lower revision rates after THR in comparison to HA of both a district general hospital (WMH) and a university
[3–5]. Moreover, patients satisfying the recommended hospital (MH) in Wales. Patients fulfilling the NICE crite-
criteria also have lower mortality following THR com- ria for THR after fracture NOF were included in the study.
pared to HA [6]. Interestingly, however, significantly The AMTS of ≥ 8 for the absence of cognitive impairment
worse mortality is evident following THR in patients and ASA score of ≤ 2 for medical fitness was used for pre-
failing to satisfy these parameters [6]. This is a particu- cise patient selection [7].
lar concern when it is considered that a recent review of The overall inclusion criteria for patient selection were:
the National Hip Fracture Database (NHFD) from 2011
to 2015 revealed that not only 32 per cent of the eligible (a) Displaced intracapsular hip fracture treated with HA or
21,193 patients received THR [7], but also that 42 per THR
cent of the total 11,683 patients treated with THR during (b) Independently mobile outdoors (requiring no more than
this period failed to meet the criteria set out by NICE [7]. one stick)
Despite the updated guidelines [1], the most recent (c) Medically fit for anaesthesia and the surgery (ASA ≤ 2)
reports from the NHFD demonstrate a minimal rise in (d) Cognitively not impaired (AMTS of ≥ 8).
the number of THRs performed for these eligible patients
(30.14 per cent in 2016–31.4 per cent in 2017 and 33.1 Exclusion criteria for the study were:
per cent in June 2018 [8]). Also, there remains a wide and
unexplained variation in the provision of THR across dif- (a) Undisplaced fracture or fractures treated with operative
ferent NHS trusts in England (ranging from 0 to 62.5%) fixation (i.e., Cannulated screws or Compression hip
[8]. The reasons for such variation in compliance is mul- screws).
tifactorial, but there is a general belief that the guidelines (b) Pathological fractures.
are simply too broad and thus result in the inclusion of a
group of patients not suitable for THR. The NHFS was collected from the hip fracture care
While current literature suggests that fit and high func- pathway used in both hospitals. Complications, re-opera-
tioning patients with NOF will clearly benefit from THR tions and revision of primary surgery were collected from
in comparison to HA, both functionally and clinically, the individual patient notes.The 30 day and one-year mortal-
procedure also demands higher skillset than undertak- ity data were also obtained from the case notes and death
ing HA [2, 9, 10]. Therefore it is imperative not only to registry office.
adhere to the recommendations set out by NICE but to try
to devise an effective clinical assessment tool to ascertain
the pre-injury physiological performance of these patients
and thus identify the subset of patients better suited to Statistical methods
THR. The NHFS is an objective assessment tool that has
been widely validated in patients with fracture NOF to The two groups of patients receiving THR and hemiar-
predict mortality and outcome, its use therefore as an throplasty of the hip (HA) were statistically compared by
adjunct to reliably define the premorbid state in patients using Pearson’s chi-square test for pre-operative mobil-
eligible for THR would seem logical [11–13]. ity (without aids: with one stick), medical fitness for the
The purpose of this study was to investigate patient- operation (ASA grade) and cognitive impairment (AMTS
specific factors predicting THR in a patient cohort ful- score). An independent sample t-test was undertaken to
filling the NICE criteria for THR after NOF. The NHFS, identify the difference in the age of the two cohorts of
American Society of Anesthesiologists physical status patients. Pearson’s chi-square test was used to ascertain
classification (ASA grade) and abbreviated mental test the difference in NHFS-categorised as 3 & below and 4
score (AMTS) at admission were used as surrogates of & above, based on predicted 30-day mortality of 3.8%
patients’ pre-morbid status. Complications, discharge vs ≥ 6.2% and the significant dichotomy of the overall per-
destination, 30 day and 1-year mortality in this group of formance of these patients with scores higher than 4 [11].
patients treated with either THR or HA, despite their eli- Furthermore, logistic regression analysis with backward
gibility for a total joint replacement, were also recorded. likelihood ratio was used to predict the type of surgery (i.e.
THR or HA) using age, NHFS, ASA grade, AMTS, pre-
operative mobility and source of admission as covariates.

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Neck of femur fracture: who gets a total hip replacement? A review of 230 eligible patients

Kaplan-Meir survival analysis with a log-rank test (Man- receiving HA (mean 81.7 years, 95% CI 80.5–82.8 years)
tel–Cox) was used to evaluate the potential difference in with conspicuously fewer patients being treated with THR
survival of the two groups of patients. A p-value of 0.05 above the age of eighty years (p < 0.01). A significant
was considered to be statistically significant. All analysis negative correlation is also noted between NHFS and the
performed in IBM SPSS 25 Inc. software. type of surgery in this group of patients (Pearson’s corre-
lation – 0.537, p < 0.01), implying higher NHFS decreases
the likelihood of patients receiving THR. It also revealed
Results that a high proportion of patients treated with THR after
hip fracture are ASA grade 1 (p = 0.018) with higher AMTS
Patient characteristics value (p = 0.002) in comparison to patients receiving HA.
Additionally, a significantly higher proportion of patients
A total of 991 patients from WMH (2011–15) and 982 receiving THR were walking independently without any
patients from MH (2016–17) with fracture NOF were iden- aids, both indoors and outdoors, in comparison to patients
tified. Inclusion criteria were met by 230 patients (114 receiving HA (p = 0.001).
patients from WMH and 116 from MH). A total of 97 (42.2 Further analysis of the patient cohorts from the two hospi-
per-cent) received THR, and 133 (57.8 per-cent) patients tals revealed comparable demographic data (Table 2). How-
received HA. ever, a statistically significant difference of age in patients
A detailed sub-group analysis (Table 1) revealed patients receiving HA in two hospital sites is noted (WMH-mean
receiving THR (mean 73.5 years, 95% CI 72–74.8 years) 80.4 years and MH- mean 83 years) although this was not the
were significantly younger in comparison to patients case for patients receiving THR (WMH-mean 72.9 years and

Table 1  Patient characteristics Table 2  Comparison of patient characteristics in two hospitals


THR HA p-value WMH MH p-value
Total number 97 133 0.001* Total number
Age (avg.years ± SD) 73 ± 6.8 81.7 ± 6.9  THR 50 47 0.7
Sex  HA 64 69
 Male 20 35 0.3** Mean age (years)
 Female 77 98  THR 72.9 73.9 0.5
ASA grade  HA 80.4 83 0.02*
 1 14 2 0.018** Sex (F:M)
 2 83 131  THR 37:13 40:7 0.17
AMTS  HA 47:17 51:18 0.9
 8 4 16 0.002** ASA Grade -1:2
 9 9 29  THR 9:41 5:42 0.3
 10 84 88  HA 0:64 2:67 0.17
Nottingham hip fracture score AMTS-8:9:10
  <  = 3 69 25 0.001**  THR 2:5:43 2:4:41 0.96
  >  = 4 28 108  HA 9:13:42 7:16:46 0.7
Mobility Nottingham Hip Fracture Score (3 & below: 4 & above)
 Without aids 93 97 0.001**  THR 30:20 39:8 0.006*
 With 1 × stick 4 36  HA 8:56 17:42 0.3
Admission source Mobility (without aids:with one stick)
 Home /sheltered accomodation 97 130 0.26  THR 48:2 45:2 0.9
 Institutional care 0 3  HA 51:13 46:23 0.12
Discharge destination Admission source (home or sheltered accomodation:institutional
 Home /sheltered accomodation 92 108 0.008** care)
 Institutional care 4 14  THR 50:0 47:0 NA
 Not available 1 11  HA 63:1 67:2 1

*Independent sample t-test *Independent sample t-test


**Pearson’s chi-square test **Pearson’s chi-square test
*** Fisher’s exact test *** Fisher’s exact test

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A. Bhattacharjee et al.

ability (p-0.001) as significant predictors for the type of sur-


gery after NOF (Nagelkerke R2-0.472). The other covariates
which failed to achieve statistical significance in the regres-
sion analysis were ASA grade (p-0.076) and patients source
of admission at the time of injury (p-0.795).

Survival analysis

There was no mortality in either cohort at 30 days. However,


nine patients treated with HA and one patient receiving THR
died at one year. The total reported mortality of patients
receiving HA was 25 (18.4 per cent) at mean 2.5 ± 1.5 years,
and THR was 5 (5.3 per cent) at 2.9 ± 1.6 years, with no
statistical significance in the difference of follow up for
Fig. 1  Distribution of NHFS in patients receiving total hip replace- the type of surgery (p-value 0.13). Kaplan–Meier survival
ment (THR) analysis showed an estimated mean survival time for the
whole cohort was 5.3 years (95% CI 5.0–5.6). A log-rank
test (Mantel and Cox) showed a statistically significant
higher estimated survival time in patients treated with THR
(estimated mean 5.9 years, 95% CI 5.6–6.20) in comparison
to HA (estimated mean 4.9 years,95% CI 4.5–5.4) (p-value
0.002) (Fig. 3).

Complications

Three patients receiving THR (two patients from WMH and


one patient from MH) and one patient treated with HA (from
WMH) had per-operative peri-prosthetic fractures requiring
revision surgeries within 30 days of the index surgery. Three
patients (one patient from WMH and two patients from MH)
treated with THR had a dislocation of the hip within 30 days
of the surgery which required a closed reduction in theatre.
However, no revision surgery was required for these patients.
Two patients in MH had dislocation after HA which had
to be revised to THR within 30 days of index surgery. One
Fig. 2  Distribution of NHFS in patients receiving hemiarthroplasty of
the hip (HA) patient treated with HA (WMH) had a leg-length discrep-
ancy which led to symptoms related to the sciatic nerve and
subsequently had to undergo revision to THR. Two patients
MH-mean 73.9 years). A statistically significant difference is in MH had an infection after HA, one deep infection requir-
also noted in the proportion of patients with NHFS <  = 3 in ing excision arthroplasty, and one superficial infection man-
the THR group in WMH (30/50 patients) with respect to MH aged non-operatively. Complications from both the group are
(39/48 patients). Nevertheless, the median NHFS score of all illustrated in Table 3.
patients treated with THR was 3 (with upper quartile being
4, noted only in WMH, Fig. 1) and 4 for patients receiving Discharge destination
HA (interquartile range 4–5, Fig. 2).
A binary logistic regression analysis (backward likeli- The discharge destination was identified in 218 patients
hood ratio) showed age (p-0.001), NHFS (p-0.001), AMTS with 12 being not available. A significantly higher propor-
(p-0.01) and walking ability (p-0.001) as significant pre- tion of patients receiving THR (92 out of 97) in comparison
dictors for the type of surgery after NOF (Nagelkerke to HA (108 out of 133) returned to their pre-injury place of
R2-0.624). Since age and AMTS of the patient are part of residence (p-0.008). There was no correlation between the
NHFS; the analysis was performed without these param- original place of residence (p = 0.14), NHFS (p = 0.39) and
eters. The results still showed NHFS (p-0.001) and walking discharge destination.

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Neck of femur fracture: who gets a total hip replacement? A review of 230 eligible patients

Fig. 3  Survival function curve


of the patients receiving hemi-
arthroplasty of the hip (HA) and
total hip replacement (THR)

Table 3  Complications in patients receiving THR and HA THR [4]. The results of our study concur with similar find-
THR HA Comments
ings of a unique subset of NICE eligible patients treated
with THR who are both high performing and young and fit.
Fracture 3 1 All of them required revision surgery Furthermore, our findings indicate that NHFS significantly
Dislocation 3 2 2 HA revised to constrained THR correlates with the likelihood of undergoing THR. The
Infection 0 2 1 excision arthroplsty NHFS is already established as a powerful validated tool
Other 0 1 Revised to THR to define pre-morbid status for patients sustaining frac-
ture NOF. We, therefore, believe that this objective tool
can be used as a surrogate to define fitness to determine
Discussion the type of surgery (THR/HA) in this particular group of
patients. This is the first study to date, attempting to use
This study demonstrates that in patients fulfilling NICE a scoring tool to help more accurately define the subset
criteria for THR, those patients who received THR exhib- of patients deemed “medically fit for the procedure”. A
ited very different characteristics from those undergo- cut off of 3 was chosen as the predicted 30-day mortality
ing HA. Younger age, low NHFS (score-3), high AMTS (3.8%) increases dramatically with an NHFS of 4 (6.2%),
(score-10) and independent unaided mobility significantly in addition to the significant difference in the overall out-
increased the likelihood of undergoing THR. In addition, come in those patients over the score of 4 [11, 13]. Our
the cohort of patients undergoing THR had a significantly study benefits from a large sample size with patient data
longer post-operative survival in comparison to patients obtained from two different hospitals representing wider
with HA. The results also show that a significantly high demographic characteristics. Our results show that a low
proportion of patients receiving THR were discharged to NHFS score (3 interquartile range 3–4), based on patients
their original residence. While there was a higher inci- pre-morbid status, increases the likelihood of receiving
dence of fracture and dislocation in patients receiving THR. Such an approach of objectively defining patients
THR in comparison to HA, the numbers were low, and with a scoring tool will potentially eliminate the more
there was no reported incidence of infection in patients subjective assessment used pragmatically in a day to day
being treated with THR. practice.
Our results support the previously published retrospec- Previous publications on THR for NOF have used ASA
tive study across eight trauma units in the North of Eng- grade as an indicator of fitness for surgery with an ASA ≤ 2
land. In this study, the authors observed that age, ASA often qualifying patients for THR [7, 14]. Although ASA
grade, AMTS and independent walking ability were sig- can help to quantify the physical fitness of these patients,
nificantly different in patients receiving THR as opposed it has the inherent weakness of poor intra and interob-
to HA when all patients fulfilled the NICE criteria for server reliability in clinical practice [7, 15]. Moreover,
not only has the NHFS been validated as a predictive tool

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A. Bhattacharjee et al.

for mortality and patient outcome after NOF [11–13, 17, Funding  No benefits in any form has been received or will be received
18], it has also been shown to outperform the other co- from any parties related directly or indirectly to the article.
morbidity indices. The use of NHFS as an adjunct to NICE
criteria by surgeons will help to reduce the ambiguity in Compliance with ethical standards 
clinical decision making about the choice of surgery and
Conflict of interest  Atanu Bhattacharjee declares that there is no con-
promote reproducibility of the selection criteria. flict of interest. Owen Richards declares that there is no conflict of
Pre-injury functional level denoted by the independ- interest. Chris Marusza declares that there is no conflict of interest.
ent outdoor walking ability with a low NHFS is strongly Claire J Topliss declares that there is no conflict of interest. Ian Wilson
associated with THR in our study. Furthermore, the sig- declares that there is no conflict of interest. Stepehen Phillips declares
that there is no conflict of interest. Ian Starks declares that there is no
nificantly younger age of patients receiving THR in com- conflict of interest.
parison to HA, with THR being done to patients < 80 years
of age (average age 73  years) remains consistent with Ethical statement  The study respected all ethical standards valid for a
previous recommendations based on the NJR data and retrospective departmental service evaluation.
observational studies [14, 19]. These features explain the Ethical comitte approval  None required
high physiological resilience amongst the patients selected
for THR on top of their fulfilment of the NICE criteria.
Such patient characteristics can be potentially related to
them being discharged back to their admission source and
longer survival in comparison to the HA group. Longer References
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