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Neck of Femur Fracture Who Gets A Total Hip Replacement A Review
Neck of Femur Fracture Who Gets A Total Hip Replacement A Review
Neck of Femur Fracture Who Gets A Total Hip Replacement A Review
https://doi.org/10.1007/s00068-020-01358-5
ORIGINAL ARTICLE
Abstract
Purpose To investigate patient-specific factors that predict Total Hip Replacement (THR) in patients with fracture neck of
femur (NOF), fulfilling the National Institute of Health and Care Excellence (NICE) criteria.
Methods Hip fracture database from a district general hospital and university hospital was retrospectively reviewed to
identify patients fulfilling NICE criteria for THR after fracture NOF. Patient demographics, Nottingham Hip Fracture score
(NHFS), complications, re-operations, revision, 30 days and one-year mortality was obtained from patient-records. Inde-
pendent predictors correlating with the outcome of surgery were identified. A logistic regression analysis was used to predict
the type of surgery in these patients.
Results A total of 230 (114 WMH and 116 MH) were identified; 133 (57.8 per-cent) received hip hemiarthroplasty (HA), and
97 (42.2 per-cent) received THR. Patients receiving THR (mean 73.5 years, 95% CI 72–74.8) were significantly younger in
comparison to patients receiving HA (mean 81.7 years, 95% CI 80.5–82.8). A negative correlation is noted between NHFS
and type of surgery (Pearson’s correlation − 0.537, p < 0.01), implying higher NHFS decreased the likelihood of receiving
THR. Regression analysis showed NHFS (p-0.001) and walking ability (p-0.001) as significant predictors for the type of
surgery (Nagelkerke R2-0.472). A log-rank test showed higher estimated survival time in patients with THR in comparison
to HA (p-value 0.002).
Conclusions NHFS and walking ability can be used as an adjunct to the NICE criteria for selecting patients for THR after
fracture NOF. Carefully selected patients treated with THR survive longer and have a better outcome in comparison to HA.
Keywords Hip fracture · Total hip replacement · Neck of femur fracture · Nottingham hip fracture score (NHFS)
Introduction
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A. Bhattacharjee et al.
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Neck of femur fracture: who gets a total hip replacement? A review of 230 eligible patients
Kaplan-Meir survival analysis with a log-rank test (Man- receiving HA (mean 81.7 years, 95% CI 80.5–82.8 years)
tel–Cox) was used to evaluate the potential difference in with conspicuously fewer patients being treated with THR
survival of the two groups of patients. A p-value of 0.05 above the age of eighty years (p < 0.01). A significant
was considered to be statistically significant. All analysis negative correlation is also noted between NHFS and the
performed in IBM SPSS 25 Inc. software. type of surgery in this group of patients (Pearson’s corre-
lation – 0.537, p < 0.01), implying higher NHFS decreases
the likelihood of patients receiving THR. It also revealed
Results that a high proportion of patients treated with THR after
hip fracture are ASA grade 1 (p = 0.018) with higher AMTS
Patient characteristics value (p = 0.002) in comparison to patients receiving HA.
Additionally, a significantly higher proportion of patients
A total of 991 patients from WMH (2011–15) and 982 receiving THR were walking independently without any
patients from MH (2016–17) with fracture NOF were iden- aids, both indoors and outdoors, in comparison to patients
tified. Inclusion criteria were met by 230 patients (114 receiving HA (p = 0.001).
patients from WMH and 116 from MH). A total of 97 (42.2 Further analysis of the patient cohorts from the two hospi-
per-cent) received THR, and 133 (57.8 per-cent) patients tals revealed comparable demographic data (Table 2). How-
received HA. ever, a statistically significant difference of age in patients
A detailed sub-group analysis (Table 1) revealed patients receiving HA in two hospital sites is noted (WMH-mean
receiving THR (mean 73.5 years, 95% CI 72–74.8 years) 80.4 years and MH- mean 83 years) although this was not the
were significantly younger in comparison to patients case for patients receiving THR (WMH-mean 72.9 years and
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A. Bhattacharjee et al.
Survival analysis
Complications
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Neck of femur fracture: who gets a total hip replacement? A review of 230 eligible patients
Table 3 Complications in patients receiving THR and HA THR [4]. The results of our study concur with similar find-
THR HA Comments
ings of a unique subset of NICE eligible patients treated
with THR who are both high performing and young and fit.
Fracture 3 1 All of them required revision surgery Furthermore, our findings indicate that NHFS significantly
Dislocation 3 2 2 HA revised to constrained THR correlates with the likelihood of undergoing THR. The
Infection 0 2 1 excision arthroplsty NHFS is already established as a powerful validated tool
Other 0 1 Revised to THR to define pre-morbid status for patients sustaining frac-
ture NOF. We, therefore, believe that this objective tool
can be used as a surrogate to define fitness to determine
Discussion the type of surgery (THR/HA) in this particular group of
patients. This is the first study to date, attempting to use
This study demonstrates that in patients fulfilling NICE a scoring tool to help more accurately define the subset
criteria for THR, those patients who received THR exhib- of patients deemed “medically fit for the procedure”. A
ited very different characteristics from those undergo- cut off of 3 was chosen as the predicted 30-day mortality
ing HA. Younger age, low NHFS (score-3), high AMTS (3.8%) increases dramatically with an NHFS of 4 (6.2%),
(score-10) and independent unaided mobility significantly in addition to the significant difference in the overall out-
increased the likelihood of undergoing THR. In addition, come in those patients over the score of 4 [11, 13]. Our
the cohort of patients undergoing THR had a significantly study benefits from a large sample size with patient data
longer post-operative survival in comparison to patients obtained from two different hospitals representing wider
with HA. The results also show that a significantly high demographic characteristics. Our results show that a low
proportion of patients receiving THR were discharged to NHFS score (3 interquartile range 3–4), based on patients
their original residence. While there was a higher inci- pre-morbid status, increases the likelihood of receiving
dence of fracture and dislocation in patients receiving THR. Such an approach of objectively defining patients
THR in comparison to HA, the numbers were low, and with a scoring tool will potentially eliminate the more
there was no reported incidence of infection in patients subjective assessment used pragmatically in a day to day
being treated with THR. practice.
Our results support the previously published retrospec- Previous publications on THR for NOF have used ASA
tive study across eight trauma units in the North of Eng- grade as an indicator of fitness for surgery with an ASA ≤ 2
land. In this study, the authors observed that age, ASA often qualifying patients for THR [7, 14]. Although ASA
grade, AMTS and independent walking ability were sig- can help to quantify the physical fitness of these patients,
nificantly different in patients receiving THR as opposed it has the inherent weakness of poor intra and interob-
to HA when all patients fulfilled the NICE criteria for server reliability in clinical practice [7, 15]. Moreover,
not only has the NHFS been validated as a predictive tool
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A. Bhattacharjee et al.
for mortality and patient outcome after NOF [11–13, 17, Funding No benefits in any form has been received or will be received
18], it has also been shown to outperform the other co- from any parties related directly or indirectly to the article.
morbidity indices. The use of NHFS as an adjunct to NICE
criteria by surgeons will help to reduce the ambiguity in Compliance with ethical standards
clinical decision making about the choice of surgery and
Conflict of interest Atanu Bhattacharjee declares that there is no con-
promote reproducibility of the selection criteria. flict of interest. Owen Richards declares that there is no conflict of
Pre-injury functional level denoted by the independ- interest. Chris Marusza declares that there is no conflict of interest.
ent outdoor walking ability with a low NHFS is strongly Claire J Topliss declares that there is no conflict of interest. Ian Wilson
associated with THR in our study. Furthermore, the sig- declares that there is no conflict of interest. Stepehen Phillips declares
that there is no conflict of interest. Ian Starks declares that there is no
nificantly younger age of patients receiving THR in com- conflict of interest.
parison to HA, with THR being done to patients < 80 years
of age (average age 73 years) remains consistent with Ethical statement The study respected all ethical standards valid for a
previous recommendations based on the NJR data and retrospective departmental service evaluation.
observational studies [14, 19]. These features explain the Ethical comitte approval None required
high physiological resilience amongst the patients selected
for THR on top of their fulfilment of the NICE criteria.
Such patient characteristics can be potentially related to
them being discharged back to their admission source and
longer survival in comparison to the HA group. Longer References
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