Group 4

Analgesic Drugs

Generic Name Paracetamol

IUPAC Name N-(4-Hydroxyphenyl) acetamide
Structure

Trade Name and Manufacturer Alaxan FR – United Laboratories

Alvedon - Multicare
Detramol - Filadams
Biogesic - UniLab
Calpol - GlaxoSmithKline
Dosage Form, Strength, and Selling Price Alaxan FR – 500mg capsule – P6.00
Alvedon – 500mg tablet – P295.00 (100’s)
Detramol – 500mg tablet – P225.00 (100’s)
Biogesic – 500mg tablet – P5.00/pc
Calpol – 120mg/5mL – P97.00
Pregnancy Category Category B
Clinical Indication It is suitable for the treatment of pains of all kinds
(headaches, dental pain, postoperative pain, pain
in connection with colds, post-traumatic muscle
pain). Migraine headaches, dysmenorrhea and
joint pain can also be influenced advantageously.
In cancer patients, paracetamol is used for mild
pain or it can be administered in combination
with opioids (e.g. codeine).

Generic Name Fentanyl

IUPAC Name N-phenyl-N-[1-(2-phenylethyl)piperidin-4-
yl]propanamide
Structure

Trade Name and Manufacturer Durogesic – Janssen

Sublimaze – Janssen
Trofentyl (India) – Troikaa
Verfen (India) – Verve
Abstral (USA) – Galena Biopharma
Dosage Form, Strength, and Selling Price Durogesic – Transdermal Patch – 12mcg/hr
(P2513.00/box); 25mcg/hr (P5332.00/box);
50mcg/hr (P9550.00/box)
Sublimaze – Injection – 0.05mcg/mL (2mL x 5 x
1’s = P1165.00/box; 10mL x 5 x 1’s =
P2328.50/box)
Trofentyl (India) – Injection – 50mcg/mL x 10mL
(133 INR); 50mcg/mL x 2mL (47 INR)
Verfen (India) – Injection – 50mcg/mL x 10mL
(185 INR); 50mcg x 2mL (45 INR)
Abstral (USA) – Sublingual tablet – 100mcg
($32.32); 200mcg ($40.56); 300mcg ($48.61);
400mcg ($58.45); 600mcg ($75.25); 800mcg
($92.01)
Pregnancy Category Category C, D (if prolonged use/ high doses at
term)
Clinical Indication For analgesic action of short duration during the
anesthetic periods, premedication, induction and
maintenance, and in the immediate
postoperative period (recovery room) as the
need arises. For use as a narcotic analgesic
supplement in general or regional anesthesia.

Generic Name Ketorolac

IUPAC Name (±)-5-benzoyl-2,3-dihydro-<brF />1H-pyrrolizine-1-carboxylic acid,
2-amino-2-(hydroxymethyl)-1,3-propanediol
Structure

Trade Names Acular


Dosage
Clinical Indication
Pregnancy Category
Manufacturer and Selling Price
Toradol
Ketomed
Remopain
Kortezor
Tablet: 10 mg
Ampule: 30 mg/ml
Ophthalmic Drops: 0.5%
For short-term management of moderate to severe acute post-op
pain
Relief of ocular itching due to seasonal allergic conjunctivitis.
Prophylaxis & reduction of inflammation & associated symptoms
after ocular surgery.
Category C
Category D (In 3rd trimester or near delivery)
Acular- Allergan- P425.50 per container (Ophthalmic Drops)
Toradol- Roche- P607.00 per box of 5’s (Amp)
Ketomed- Medhaus- P430.00 per box of 5’s (Amp)
Remopain- Gracio Med- P473.29 per box of 5’s (Amp)
Kortezor- Biomedis- P940.35 per box of 10’s (Amp)

Generic Name Tramadol HCl

IUPAC Name (1R,2R)-2-[(dimethylamino)methyl]-1-(3-
methoxyphenyl)cyclohexan-1-ol
Structure
Trade Name and Manufacturer
Dosage Form, Strength, and Selling Price
Pregnancy Category
Clinical Indication
Clomadol – Mount Mettur
Dolotral – Stada
Tramid – Euro-Med
Siverol – Biomedis
TDL - Patriot
Clomadol – Injection – 50mg/mL (P1040.00/box)
Dolotral – Capsule – 50mg (P530.00/pack);
Injection – 100mg/2mL (P530.00/box)
Tramid – Powder for injection – 50mg/mL (1mL =
P92.40; 2mL = P135.52)
Siverol – Capsule – 50mg (100’s = P2378.67);
Injection (100mg/2mL = P138.98; 50mg/mL =
P94.08)
TDL – Capsule – 50mg (50’s = P1056.90); Injection
– 50mg/mL (2mL x 10 x 1’s = P1050.80/box)
Category C
For the relief of moderate to severe pain
Moderate to severe pain especially post-op or
due to trauma, colic, ischemia, or cancer
Moderate to severe acute and chronic pain,
painful diagnostic procedures and surgery

Generic Name Celecoxib

IUPAC Name 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-
1-yl]benzenesulfonamide
Structure
Trade Name and Manufacturer
Dosage Form, Strength, and Selling Price
Pregnancy Category
Clinical Indication
Celebrex – Pfizer
Aubrex – Corbridge
Celcoxx – Getz Pharma
Pharex Celecoxib - Pascual
Celebrex – Capsule - 100mg x 60’s (P2, 311.17),
200mg x 60’s (P3, 364.21), 400mg x 60’s (P4,
540.42)
Aubrex – Capsule - 200 mg x 50’s (P1,300)
Celcoxx – Capsule - 100mg x 20’s (P414.35),
200mg x 20’s (P599.25), 400mg x 20’s (P930)
Pharex Celecoxib - 100mg x 60’s (P720;P12/cap),
200mg x 60’s (P1,200;P12/cap)
Category C; D in 3rd trimester or near delivery
1. For relief of the signs and symptoms of
osteoarthritis. 
2. For relief of the signs and symptoms of
rheumatoid arthritis in adults. 
3. For the management of acute pain in adults.
4. For the treatment of primary dysmenorrhea.
5. To reduce the number of adenomatous
colorectal polyps in familial adenomatous
polyposis (FAP), as an adjunct to usual care
(e.g., endoscopic surveillance, surgery).