Pathology of The Female Genital Tract Course Outline

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University of Santo Tomas

Faculty of Medicine and Surgery


Department of Pathology

Pathology of the Female Genital Tract


Course Outline
Rolando A. Lopez, MD, FPSP

COURSE OBJECTIVES:
1. Recognize the common lesions that develop in the vulva,
vagina, cervix, corpus, fallopian tubes and ovaries.
2. Define Squamous Intraepithelial Lesion as it involves, the
vulva, vagina, and cervix
3. Discuss the pathogenesis of cervical cancer
4. Enumerate the causes of abnormal uterine bleeding
5. Differentiate between non-atypical and atypical endometrial
hyperplasia
6. Discuss the pathogenesis of endometrial carcinoma
7. Define the parameters to distinguish between benign and
malignant smooth muscle tumors
8. Enumerate the four classes of ovarian neoplasms and the
tumors under each class
9. Define the concept of Borderline tumors among the surface
epithelial tumors of the ovary
10.Recognize the differences among Partial Mole, Complete Mole
and Choriocarcinoma

I. VULVA:
A. Dystrophy: 1. Lichen simplex chronicus; 2. Lichen
sclerosus
B. Vulvar Intraepithelial Neoplasia
C. Vulvar carcinoma
D. Paget Disease

II. CERVIX
A. Squamous Intraepithelial Lesion: Low grade & High
grade
B. HPV: low risk and high risk types
C. Cervical carcinoma
III. CORPUS UTERI
A. Endometrial Hyperplasia
B. Endometrial Carcinoma: Types
C. Other causes of abnormal uterine bleeding: 1.
Endometrial polyp; 2, Adenomyosis
D. Leiomyoma vs. Leiomyosarcoma

IV. OVARY
A. Surface Epithelial-Stromal Tumors : Benign,
Borderline, Malignant
1. Endometrioid; 2. Mucinous; 3. Serous; 4. Clear
cell; 5. Brenner
B. Sex Cord Stromal Tumors: 1. Granulosa Cell Tumor;
2.Fibroma; 3. Thecoma
C. Germ Cell Tumors: 1. Dysgerminoma; 2. Yolk Sac
Tumor; 3. Teratoma
D. Metastatic/ Secondary Tumors
E. Ovarian cysts: Follicle cyst, Germinal Inclusion cyst,
Endometrial cyst

V. GESTATIONAL TROPHOBLASTIC DISEASES


A. Hydatidiform Mole: Partial, Complete
B. Choriocarcinoma

LIST OF SLIDES FOR THE MODULE

1. CHRONIC CERVICITIS WITH SQUAMOUS METAPLASIA AND


NABOTHIAN CYSTS
2. SQUAMOUS CELL CARCINOMA, KERATINIZING, CERVIX
3. PROLIFERATIVE PHASE ENDOMETRIUM
4. NON-ATYPICAL ENDOMETRIAL HYPERPLASIA
5. ENDOMETRIOID ADENOCARCINOMA, ENDOMETRIUM
6. LEIOMYOMA, INTRAMURAL
7. ADENOMYOSIS
8. MUCINOUS CYSTADENOMA, OVARY
9. BORDERLINE MUCINOUS CYSTIC TUMOR. OVARY
10. MATURE CYSTIC TERATOMA, OVARY
11. TUBAL PREGNANCY

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