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Andrea Fiorillo
Professor of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie, 80138, Naples, Italy.
E-mail: andrea.fiorillo@unicampania.it
Sophia Frangou, MD, PhD, FRCPsych
Professor of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425, Madison Avenue, New York, NY 10029, USA,
Tel.: (01) 212-659-1668; E-mail: sophia.frangou@mssm.edu
Reinhard Heun
Professor of Psychiatry, Radbourne Unit, Royal Derby Hospital, Uttoexter Road, Derby, DE 223WQ UK, Tel.: (44) 1332-623877;
E-mail: reinhard.heun@derbyshcft.nhs.uk
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Imprimé en France par Jouve, 53101 Mayenne.

Dépôt légal à parution
Vol. 56, Supplement April 2019
CONTENTS
Abstracted in: BIOSIS/Biological Abstracts, Current Contents/Clinical Medicine and Social & Behavioural Sciences, EMBASE/
Excerpta Medica, MEDLINE/Index Medicus, PASCAL/INIST-CNRS, Psychological Abstracts, PsycINFO, PsyLIT, Research
Alert, SciSearch
Abstracts of the 27th European Congress of Psychiatry - 2019
Debate ........................................................................................................................................................................................ S1
E-Poster Presentation ................................................................................................................................................................. S3
E-Poster Viewing ....................................................................................................................................................................... S445
ECP Program ............................................................................................................................................................................. S779
EPA Forum 2019 ....................................................................................................................................................................... S783
Joint Symposium ....................................................................................................................................................................... S784
Joint Workshop .......................................................................................................................................................................... S788
Oral Communications ................................................................................................................................................................ S789
Plenary ....................................................................................................................................................................................... S844
Presidential Symposium ............................................................................................................................................................ S845
Symposium ................................................................................................................................................................................ S847
State of the Art ........................................................................................................................................................................... S886
Workshop ................................................................................................................................................................................... S888
European Psychiatry 56S (2019) S1–S2
Contents lists available at ScienceDirect
European Psychiatry
journal homepage: http://www.europsy-journal.com
Debate
D001 Mostly based on the results of the EUNOMIA study, still the largest
prospective study on the use and outcomes of coercive measures
(involuntary hospitalization, mechanical restraint, forced medica-
Con tion, seclusion) in general hospital psychiatry ever conducted, the
Clinical/therapeutic: debate: sexual presentation will outline that
1. Coercive interventions are a medico-legal and clinical reality in
addiction: does it exist? Europe, but show significant variation across countries; further,
A. Weinstein
patients’ views on involuntary hospitalization also differ across
University of Ariel, Behavioral Science, Airel, Israel
sites
It has been argued that compulsive sexual behavior (CSB) simi- 2. There might be a link between the extent to which national men-
lar to pathological gambling (PG), meets the criteria for addiction. tal health legislation protects patients’ rights and the extent to
There is evidence showing that compulsive sexual behavior has the which patients retrospectively evaluate that their involuntary
characteristics of addiction such as salience, mood modification, admission was appropriate
tolerance, withdrawal and adverse consequences. There are studies 3. Patients who feel coerced to admission may have a poorer prog-
that have shown that exposure to visual sexual stimuli in individ- nosis than legally involuntary patients
uals with compulsive sexual behavior is associated with activation 4. Effective treatment of positive symptoms and improving
of reward mechanisms similar to drug addiction. Cross-sectional patients’ global functioning may lead to a reduction in perceived
studies report high rates of co-morbidity between compulsive coercion
sexual behavior and other psychiatric disorders such as depres- 5. Caregivers’ appraisals of involuntary inpatient treatment corre-
sion, anxiety; Attention Deficit Hyperactivity Disorder (ADHD), late with patients’ symptom improvement
obsessive–compulsive disorder (OCD) and personality disorders. Conclusion.– If compulsory treatments in psychiatric practice are
However, despite many similarities between the features of hyper- needed is an open question. Many aspects of the use of such inter-
sexual behavior and substance-related disorders there are gaps ventions deserve deeper attention in research and clinical practice.
in our knowledge on compulsive sexual behavior and its treat- The complexity of this field is such that simple pro-con answers are
ment which precludes a definite conclusion that this is a behavioral not possible. In general, we have to work on a standard of clinical
addiction rather than an impulse control disorder. Therefore, more practice guided by respecting autonomy and rights of our patients
research is needed before definitively characterizing HD as an to the utmost.
addiction at this time. This talk will review the empirical evidence Disclosure of interest.– The authors have not supplied a conflict of
and it will summarize the arguments against considering sexual interest statement.
addiction as a behavioral addiction (the cons side).
Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
D003
D002 Con
Mental health policy: debate: do we
need compulsory treatments in
Pro psychiatric practice?
Mental health policy: debate: do we G. Szmukler
need compulsory treatments in King’s College London, Institute of Psychiatry- Psychology and
psychiatric practice? Neuroscience, London, United Kingdom
T. Kallert
I shall argue that involuntary treatment can be unnecessary in the
Psychiatric Health Care Facilities of Upper Franconia GeBO,
practice of psychiatry. This is the position taken by a number of
Bezirkskrankenhaus Bayreuth, Bayreuth, Germany; Dresden
UN treaty bodies, including the UN Committee for the Convention
University of Technology, Faculty of Medicine, Dresden, Germany;
on the Rights of Persons with Disabilities (CRPD), the UN Work-
Department of Psychiatry, Psychotherapy, and Psychosomatic
ing Group on Arbitrary Detention and the UN Commissioner on
Medicine, Bayreuth, Germany
https://doi.org/10.1016/j.eurpsy.2019.01.004
0924-9338/© 2019 Published by Elsevier Masson SAS.
S2 Debate / European Psychiatry 56S (2019) S1–S2
Human Rights. Other UN bodies’ positions are less explicit about an Current clinical high-risk (CHR) of psychosis criteria – particularly
absolute prohibition on involuntary interventions, but are framed criteria relying on attenuated or transient positive symptoms and
in terms that support a central role for ‘will and preferences’, a key cognitive basic symptoms – are associated with conversion rates
concept in the UN CRPD. They call for an urgent need to develop many times higher than the general incidence of psychosis. Yet,
alternatives to coercive interventions. An important Resolution non-conversions still outnumber conversions, and CHR-relevant
on Mental Health and Human Rights from the UN Human Rights phenomena are not uncommon in the community, fueling an
Council calls upon States to “abandon all practices that fail to ongoing debate about their justification. This debate, however,
respect the rights, will and preferences of all persons, on an equal widely disregards main general findings: persons meeting CHR
basis” and to “provide mental health services for persons with criteria already suffer from multiple mental and functional distur-
mental health conditions or psychosocial disabilities on the same bances for those they seek help; they exhibit various psychological
basis as to those without disabilities, including on the basis of free and cognitive deficits along with morphological and functional
and informed consent”. cerebral changes, whereby, the majority of them fulfils general
I shall note the huge variation, twenty- to thirty-fold, between criteria for mental disorders; and beyond their association with
European countries in the use of involuntary treatment, imply- subsequent psychotic disorders, CHR criteria do not specifically
ing unacceptable arbitrariness in its use. Attention will be drawn associate with any other mental disorder. Furthermore, while CHR
to the negligible research effort devoted to developing treatment symptoms might not be uncommon in the general population,
approaches for the avoidance of coercive interventions. I shall CHR criteria almost as rare as psychotic disorders and, already
then show how a focus on supportive measures aimed at enhanc- at mere symptom level, are considerably associated with proxy
ing patients’ involvement in their care, together with a focus on measures of clinical relevance on community level, including low
respecting the person’s ‘will and preferences’ would result in invol- psychosocial functioning. Hence, the clinical picture defined by
untary treatment becoming unnecessary. current CHR criteria might not be perceived only in terms of a
Disclosure of interest.– The authors have not supplied a conflict of psychosis-risk syndrome alone but rather as a psychosis-spectrum
interest statement. disorder in its own right with conversion to psychosis just being
one and likely the worst of several outcomes and still the best
available starting-point for an early detection of psychosis. Thus,
the UHR paradigm clearly should not be abandoned but might
D004 rather act as a model for the early detection of other mental
disorders.
Con interest statement.
Mental health policy: debate: should
the UHR paradigm for transition to
mental disorder be abandoned?
F. Schultze-Lutter
Heinrich-Heine University- Medical Faculty, Department of
Psychiatry and Psychotherapy, Düsseldorf, Germany
European Psychiatry
E-Poster Presentation
E-Poster Presentation: Anxiety Disorders and E-PP0002

Somatoform Disorders - Part I Pharmacological prevention of
post-traumatic stress disorder and
acute stress disorder: a systematic
E-PP0001 review and meta-analysis
Prevalence of separation anxiety L. Astill Wright1* , M. Sijbrandij2 , R. Sinnerton3 , C. Lewis3 , N.P.
disorder in adult outpatients in Russia Roberts3 , J. Bisson3
A. Avedisova, I. Arkusha* , K. Zakharova 1 University of York, Department of Health Sciences, York, United
Federal State Budgetary Institution, V. Serbsky National Medical Kingdom; 2 VU University Amsterdam, Department of Clinical
Research Centre for Psychiatry and Narcology» of the Ministry of Psychology, Amsterdam, Netherlands Antilles; 3 Cardiff University
Health of the Russian Federation, Therapy of Mental and Behaviour School of Medicine, Institute of Psychological Medicine and Clinical
Disorders Department, Moscow, Russia Neurosciences, Cardiff, United Kingdom
* Corresponding author. * Corresponding author.
Background and aims.– The aim of the study was to assess the preva- Background and aims.– Post-traumatic stress disorder (PTSD) is a
lence of adult separation anxiety disorder (ASAD) in an outpatient common mental disorder associated with significant distress and
psychiatric network. reduced functioning. Its occurrence after a severe traumatic event
Methods.– Cohort of 366 outpatientsages 18 and above was and association with characteristic neurobiological changes make
assessed by the Adult Separation Anxiety Questionnaire (ASA-27). PTSD a good candidate for pharmacological prevention. This study
Patients who scored ≥22 by the ASA-27 were examined using the sought to establish the efficacy of pharmacological prevention of
clinical-psychopathological method, the Structured Clinical Inter- PTSD.
view for Separation Anxiety Symptoms (SCI-SAS). The comorbid Methods.– A systematic search was undertaken to identify
pathology was evaluated using the Mini-International Neuropsy- randomised controlled trials (RCTs) which used early pharma-
chiatric Interview (MINI). cotherapy (within three months of a traumatic event) to prevent
Results.– Of the 366 patients examined using ASA-27, 96 patients and treat PTSD and ASD in children and adults. Using methodol-
(26.2%) scored of 22 points and above and had somesubclinical ogy advocated by the Cochrane Collaboration, RCTs were identified
symptoms ASAD. The clinical-psychopathological analysis of these and rated for risk of bias. Available data was meta-analysed to cal-
patients, as well as the use of SCI-SAS, allowed to estimate the culate risk ratios (RR) for PTSD prevalence and stanardised mean
prevalence of TRS in adults of 6.01% (22 patients). In the majority differences (SMD) for PTSD severity.
of patients (68.2%) ASAD first manifested in childhood. The aver- Results.– Nineteen RCTs met the inclusion criteria; 15 studies with
age age of onset in these ASAD patients was 8.9 ± 4.4. In 31.8% of adult participants and four with children. The methodological qual-
cases, the patients had first onset of the disorder in adulthood, with ity of most trials was low. Only hydrocortisone in adults was found
an average age of 34.9 ± 11.5 years. Data on concomitant disorders to be superior to placebo (3 studies, n = 88, RR: 0.21 (CI 0.05 to
indicate high rates of comorbidity with other mental disorder: 50% 0.89) although this was in populations with severe physical illness,
of cases with mood disorders, 45.3% with anxiety disorders, 9.1% raising concerns about generalisability. No significant effects were
with schizotypal disorders. found for the other pharmacotherapies investigated (propranolol,
Conclusions.– The results of this study show that there is a high oxytocin, gabapentin, docosahexaenoic acid, fish oil, escitalopram,
prevalence of ASAD among outpatients. ASAD is associated with imipramine and chloral hydrate).
different comorbidities. These data correspond to those available Conclusions.– Hydrocortisone shows the most promise, of pharma-
in the literature. Further study of ASAD in the Russian population cotherapies subjected to RCTs, as an emerging intervention in the
is needed to develop approaches to managing patients with ASAD. prevention of PTSD and should be a target for further investiga-
Disclosure of interest.– The authors have not supplied a conflict of tion. There is currently a lack of evidence to suggest that other
interest statement. pharmacological agents are likely to be effective.
interest statement.
S4 E-Poster Presentation / European Psychiatry 56S (2019) S3–S444
E-PP0003 a psychiatric disorder after been presented in Primary care depart-

Affective temperaments in panic ment. The patients were asked about the duration of physical
disorder symptoms, if that was the first medical evaluation for these com-
Z. Bélteczki1* , P. Döme2 , X. Gonda2 , S. Rózsa3 , J. Újvári1 , Z. Rihmer2 plains.
1 Kálmán Sántha Psychiatric Hospital, I. Psychiatric Department, Results.– In 42% of cases this was the first visit for their complains.
Nagykálló, Hungary; 2 Department of Psychiatry and Psychotherapy- About 58% of the patients referred that they had done previous
Semmelweis University, National Institute for Psychiatry and medical visits for their complains, and weren’t referred to a psychi-
Addictions, Budapest, Hungary; 3 Loránd Eötvös University, atrist evaluation. In 23% of the cases in the latter group, the patients
Department of Personality and Health Psychology, Budapest, Hungary were referred to a neurologist for suspected anxiety disorders.
* Corresponding author. Conclusions.– Missed psychiatric diagnosis is often present in pri-
mary care, usually when clinicians do not attempt to access
Background and aims.– The nature and role of affective tempera- sufficient information about the history of illness. A more detailed
ment in the genesis, evolution and outcome of major mood disorder medical history, more devotion and less stigma, can lead to early
is well studied (Rihmer et al., 2010), but there are only few reports diagnosis and a better approach to psychiatric disorders.
on the relationship between panic disorder and affective tempera- Disclosure of interest.– The authors have not supplied a conflict of
ments. interest statement.
Methods.– We have investigated the distribution of five affec-
tive temperaments (depressive, DE; cyclothymic, CT; irritable, IR;
hyperthymic, HT; and anxious, ANX) among our outpatients with E-PP0005
panic disorder. What is the impact of the perceived
We have collected data on ICD 10 diagnosed panic disorder out- stress level in multiple sclerosis
patients from 30 Sept.2016 to 30. Sept. 2017. In all 118 patients, patients?
80 female (68%) and 38 male (32%) have been included. Affec- M. Chakroun* , S. Sakka, O. Hdiji, N. Farhat, H. Haj Kacem, M.
tive temperaments were evaluated by the TEMPS-A (Temperament Dammak, C. Mhiri
Evaluation of Memphis, Pisa, Paris and San Diego - Autoquestion- Habib Bourguiba university hospital, department of neurology, Sfax,
narie) instrument (Rózsa et al., 2008). Tunisia
Results.– The average age of patients was 44.4 years. Comorbid ago- * Corresponding author.
raphobia, unipolar depression and bipolar disorder were present in
74%, 64%, and 21% of patients. Among females the dominant depres- Background and aims.– Multiple sclerosis (MS) is a neurologic,
sive, and anxious temperaments were 3 and 4 times more common chronic disease in which stress and stressful events may play as
than in the general population of Hungary (DE: 10% vs 3,4%; p < 0,01, a trigger in the occurrence and the relapse of its symptoms.
ANX: 20% vs 4,8%, p < 0,0001). Among male patients only depres- The aim of this study was to evaluate the level of the perceived
sive temperament was slightly overrepresented (DE:7,9% vs 2,7%, stress and its impact in MS patients.
not significant). Methods.– A cross-sectional and analytical study was carried out
Conclusions.– Specific affective temperament profile is characteris- on 31 patients with MS. Demographic data, duration of the dis-
tic primarily for female panic disorder patients, but this study needs ease and the disease course were extracted from patients’ medical
replication. files. The severity of the perceived stress (PS) was evaluated by the
Reference.– Rihmer Z. et al, Curr Opin Psychiat, 2010; 23: 12–18. Perceived Stress Scale (PSS), anxiety and depression by the Hospital
Rózsa S. et al, J Affect Disord, 2008; 106: 45–53. Anxiety and Depression Scale (HADS), and the level of disability by
Disclosure of interest.– The authors have not supplied a conflict of the Expanded Disability Status Scale (EDSS).
interest statement. Results.– The average age was 34, 19 ± 10 years old. Relapsing
remitting MS occurred in 80, 6% of cases. The mean EDSS score
was 3.8 ± 2.6. Vesicosphincteric disorders was reported by 35.5%
E-PP0004 of patients. The majority of them were jobless and had a physical
Somatization and the recognition of disability (67.7%). The mean PSS score was 25.45 ± 9.
psychiatric disorders in primary care. Increased (PS) was significantly correlated to depression (p = .0001),
anxiety (p = 0.006), joblessness (p = 0.004), physical disability
What are we missing?!
(p = 0.002), Vesicosphincteric disorders (p = 0.01) and an EDSS
S. Bitri1* , E. Sotiri2 , E. Thoma3
1 score ≥ 5 (p = 0.01).
Sonila Tivari Bitri Department of Clinical Toxicology and Addiction
Conclusions.– Perceived Stress in MS can become a kind of “vicious
Medicine- American Hospital- Tirana- Albania, Department of
circle.” Therefore, for a person with multiple sclerosis, stress man-
Clinical Toxicology and Addiction Medicine- American Hospital-
agement is not so much an option as a necessity.
Tirana- Albania, Tirana, Albania; 2 University Hospital Center
“Mother Theresa”- Tirana- Albania, Department of Psychiatry-
interest statement.
Psychiatric Emergency Unit. University Hospital Center “Mother
Theresa”- Tirana- Albania, Tirana, Albania; 3 University of medicine-
Albania, University of medicine- Albania, Tirana, Albania
* Corresponding author. E-PP0006
Did depressed patients suffering from
Background and aims.– Diagnostic assessment of psychiatric disor- neuropathic pain have a poor quality
ders remain a challenge for many clinicians, especially when the of life?
patient refers too many symtoms and there are no practical labo- F. Cherif1* , R. Damak2 , H. Zouari3 , M. cheour2 , M. Haddad4
ratory tests to facilitate the psychiatric diagnostic process. 1 Hédi Chaker University Hospital, Psychiatry C, Sfax, Tunisia; 2 Razi
Objective.– The aim of this study was to evaluate the causes of Hospital, departement of psychiatry Ibn Omrane, Mannouba, Tunisia;
late detection of psychiatric disorders and prevalence of missed 3 Hédi Chaker University Hospital, Department of functional
diagnosis in primary care. exploration, Sfax, Tunisia; 4 Rabta Hospital, Pain Treatment Center,
Methods.– This is a prospective study conducted in American Hos- tunis, Tunisia
pital of Tirana, Albania during August 2015–January 2018. We * Corresponding author.
analyzed data from the files of the 134 patients diagnosed with
E-Poster Presentation / European Psychiatry 56S (2019) S3–S444 S5
Background and aims.– Despite the prevalence of neuropathic pain, and represents the anxiety somatization (as combined with other
and the acknowledgment that pain, can reduce quality of life, a scores), while the second scale elevations are typical for patients
comprehensive assessment of its psychosocial burden is lacking. with increased anxiety levels.
Our objective was to demonstrate the relationship between the Conclusions.– Therefore, the emotional associative connections
depression and the quality of life on patient suffering from neu- with the various forms of functional intestinal disorders allow
ropathic pain. determination of therapy approaches and psychotherapeutic cor-
Methods.– We conducted a multicenter observational study includ- rection methods.
ing patients consulting for neuropathic pain at the Pain Treatment Disclosure of interest.– The authors have not supplied a conflict of
Center in Tunis and the functional exploration department in Hedi interest statement.
Chaker Hospital. The diagnosis and intensity of neuropathic pain
were assessed according to the neuropathic pain questionnaire
(DN4) and the visual analog evaluation scale, respectively. The E-PP0008
impact of neuropathic pain was assessed with the brief pain inven- Analysis of interrelations between
tory (BPI). Depression was evaluated according to the Hospital pain syndrome level and actual
Anxiety and Depression Scale.
psychological status in patients with
Results.– Sixty-one patients were recruited. The sex ratio was 0.52.
The mean age was 52.7 ± 14.3 years. The average of pain inten- irritated bowel syndrome with
sity was 7.57 ± 1.73. The mean DN4 score was 6.49 ± 1.54. The diarrhea
disease impact on quality of life was moderate (mean global BPI: N. Chernus1* , R. Gorenkov2 , T. Savina1 , A. Zolotovickaja1 , S.
5.53 ± 1.76). Forty patients had depressive symptomatology with Sivkova1 , A. Sivkov3
1 I.M. Sechenov First Moscow State Medical University, Outpatient
a mean depression score of 12.9 ± 3.79. Significant correlations
were found between the depression score and the BPI score (p = 0, Care Department, Moscow, Russia; 2 I.M. Sechenov First Moscow
r = 0.59). Some items were correlated to depression: capacity of State Medical University, Higher Healthcare Organization
walk (p = 0, r = 0.49), relation with others (p = 0, r = 0.5), sleeping Management, Moscow, Russia; 3 I.M. Sechenov First Moscow State
(p = 0.004, r = 0.25) and enjoyment of life (p = 0.001, r = 0.42). Medical University, Department of Clinical Pharmacology and
Conclusions.– Depression and pain had both individual and additive Internal Diseases Propaedeutics of the Medical Faculty, Moscow,
adverse associations with quality of life. Enhanced detection and Russia
* Corresponding author.
management of this disabling symptom dyad is warranted.
Background and aims.– Interrelation between chronic pain syn-
interest statement.
drome and non-psychotic disorders of various duration and
manifestations has been the subject of extensive studies.
E-PP0007 Methods.– The study enrolled 37 patients (10 male and 27 female)
with IBS-D. The average subject age was 32,3 ± 12 years. In order
Peculiarities of actual negative
to achieve the study objective, MMPI method, TAS test, VAS scale
emotional conditions in patients with and McGill Pain Questionnaire were used.
chronic functional intestinal disorders Results.– Study results indicated that the high pain syndrome (PS)
N. Chernus1* , R. Gorenkov2 , S. Sivkova1 , A. Sivkov3 , A. level by VAS scale correlated with the elevated T-scores by MMPI
Zolotovickaja1 , T. Savina1 scales (at ≥80 T-scores and high) г = 0,824, p < 0,01, the profile type
(depressive, depressive-anxious) г = 0,729, p < 0,01, and high alex-
Care Department, Moscow, Russia; 2 I.M. Sechenov First Moscow ithymia levels г = 0,562, p < 0,01. When the profile level decreased
State Medical University, Higher Healthcare Organization to 70 T-scores, the correlation with PS was г = 0,426, p < 0,01, while
Management, Moscow, Russia; 3 I.M. Sechenov First Moscow State the correlations with the profile type and alexithymia levels were
Medical University, Department of Clinical Pharmacology and preserved at the same level г = 0,652, p < 0,01. The inverse cor-
Internal Diseases Propaedeutics of the Medical Faculty, Moscow, relation was observed between the elevated PS level and profile
Russia level location in the lower continuum part (65 T-scores or less)
г = −0,232, p < 0,01, while the correlations with the profile type
and alexithymia levels were preserved at the same level г = 0, 825,
Background and aims.– Emotional disturbances in patients with
p < 0,01.
functional intestinal disorders are of etiological significance and act
Conclusions.– The data obtained allow correction of psychotropic
as an essential component of pathomorphosis. Study of this phe-
drugs dosage and inclusion of non-pharmaceutical methods into
nomenon allows improvement of the diagnostic, therapeutic and
the treatment schemes for patients with high alexithymia levels.
preventive measures.
Methods.– The study enrolled 114 patients (26 male and 88 female)
interest statement.
with irritable bowel syndrome (IBS-D, IBS-C, IBS-M and IBS-U),
functional constipation (FC) and functional diarrhea (FD). The aver-
age subject age was 43,6 ± 11 years. In order to achieve the study E-PP0009
objective, MMPI method was used.
Panic attack in the emergency service:
Results.– In general, the averaged subject profile comparative anal-
ysis results showed that the profile with leading peak score by the sample description
first scale was observed by 2,1 times more often than the pro- M. Cotter* , A. Carvalho, S. Casinhas, P. Filipa
file with leading peak score by the second scale: 58,3 ± 16,6 vs. Centro hospitalar médio Tejo, Psiquiatria, Tomar, Portugal
27,34,7, respectively p < 0,01 and significantly higher than other
profile types (peak score by 3, 4 and 6 scales), 58,3 vs. 18,5 ± 11,6 Background and aims.– The panic attack is a sudden episode of
respectively. The second most common profile type was the pro- severe anxiety, fear or discomfort that leads to physical and emo-
file with leading peak score by the second scale (various levels tional symptoms. These can take the form of palpitations, chest pain
by 9 score and score combinations). Such tendency was the most or discomfort, choking or smothering feelings, dizziness, feelings
prominent in patients with IBS-U 35%, as compared to 33,4% in FD of unreality, dyspnea, paresthesia, hot flushes, sweating, faintness,
patients and 31% in IBS-D patients, p > 0,05. The first scale elevation trembling or fear of dying/going mad.
indicates the patient’s concerns regarding his/her physical health
Often associated with a sense of impending doom, these symptoms E-PP0011

can be similar to symptoms of a heart attack or stroke, leading these New herbal treatment for depression
patients to emergency service regularly.
and anxiety disorders with minimal
The duration of the attack may vary from less than one to sev-
eral hours taking usually about 10 to 20 minutes, being potentially
side-effects increase BDNF level in the
caused by something frightening or just no reason at all. hippocampus
We have tried to establish the prevalence of panic attacks in R. Doron1,2* , M. Franko3,4 , R. Toledano2 , S. Armoza3 , M. Rehavi5
1 The Open University of Israel, Department of Education and
patients who resort to the emergency department. We also sought
to characterize the cohort of patients with panic disorder in terms of Psychology, Raanana, Israel; 2 Academic College of Tel Aviv-Yaffo,
social-demographic, psychiatric co-morbidity, treatment and guid- School of Behavioral Sciences, Tel- Aviv, Israel; 3 Ben-Gurion
ance. University of the Negev, Psychology, Beer-Sheva, Israel; 4 Ben-Gurion
Treatment for panic attacks involves psychological therapy, medi- University of the Negev, Zlotowski Center for Neuroscience, Beer
cation, or both. Sheva, Israel; 5 Tel-Aviv University, Department of Physiology and
With this study, the authors wanted to characterize the patients Pharmacology- Sackler Faculty of Medicine, Tel Aviv, Israel
who went to the Psychiatric Emergency Service of the Centro Hos-
pitalar Médio Tejo (CHMT) during 2016 due to panic attack, taking
Background and aims.– SSRIs were shown to be effective in treat-
into account socio-demographic data, type of crisis, treatment and
ing a wide spectrum of anxiety and depression disorders. Despite
further outcome.
their therapeutic actions, SSRIs are associated with a wide variety
Methods.– Retrospective study of data from the clinical trials of
of side effects such as weight changes, insomnia and sexual dys-
patients who were referred to the CHMT emergency department
function, and studies show relatively low success rates, reaching
for panic attack.
50% at most. Therefore, there is a clear need to explore alterna-
Results.– Work in progress.
tive treatments for anxiety and depression disorders. We have
Conclusions.– Work in progress.
recently produced a novel herbal mixture for the treatment of
anxiety disorder. The novel treatment displayed anxiolytic and
interest statement.
antidepressant-like effects in treated mice previously exposed to
stress. The aim of the present study was to examine whether the
E-PP0010 novel treatment induce two common side effects normally induced
by the conventional treatment with the SSRI escitalopram: sexual
Comparative analysis of anxiety dysfunction and weight gain.
disorder among patients, suffering Methods.– Mice were treated with either: herbal treatment, one of
from cardiac disease the four herbal components, escitalopram or control group. Follow-
S. Djalilova ing treatment, sexual behavior and weight gain were evaluated, as
Tashkent Medical Academy, Department of psychiatry and narcology, well as changes in PFC serotonin transporter (SERT) levels.
Tashkent, Uzbekistan Results.– The novel treatment has not altered sexual behavior and
did not cause a weight gain, while escitalopram did lead to these
two side effects. Interestingly, SERT levels in the PFC of the esc-
Background and aims.– As it is widely accepted, anxiety disorder is italopram group were significantly lower compared to the other
common symptom of many chronic somatic diseases. groups, while the BDNF levels in the hippocampus increased both
So my purpose was to conduct comparative analysis of anxiety in ecitalopram and herbal treatment groups.
disorder among patients, suffering from cardiac disease. Conclusions.– These results suggest that the novel treatment may
Methods.– The study included 96 patients with disturbing compo- have the same behavioral anxiolytic and antidepressant efficacy as
nent in cardiac division of hospital (mean age 45 ± 4.5 years, 61 SSRIs, while causing fewer side effects, possibly due to different
men and 35 women). They were divided to: Group I - 32 patients biological mechanisms.
with essential hypertension; Group II - 30 patients with arrhythmic Disclosure of interest.– The authors have not supplied a conflict of
form of ischemic heart disease (IHD); Group III - 34 patients with interest statement.
stable angina pectoris at IHD. Assessment of anxiety disorder was
conducted using the Hanin & Spielberger’s scale.
Results.– Results showed that high level of situational anxiety E-PP0012
(mean score 51 ± 4.5) was revealed in patients of Group II - 78%,
A 10 year study of dissociative stupor
the expressed component of anxiety was lack of self-confidence
(87%), sense of constraint (93%). High level of personal anxiety and possession in a private psychiatry
(mean score 53 ± 3.7) was noted by patients of Groups I and III - OPD
83%: 79%. In group I the most significant component of anxiety was D. Dua1* , P. Dua2
1 ‘Kripya- Dua Neuropsychiatric Centre, Psychiatry, Lakhimpur Kheri,
melancholy (88%), decay (91%), apathetic mood (78%). In Group III
the fixation on past disappointments (84%), constant expectation India; 2 NIMHANS, Psychiatry, Bengaluru, India
of difficulties (92%) [ = 0,04] predominated.
Conclusions.– So situational anxiety with predominance of uncer-
Background and aims.– Dissociative Disorders were suggested to be
tainty and low self-esteem is characteristic of patients with
on the vain in earlier studies. The present study, when analysed for
arrhythmic form of ischemic heart disease. At the same time, per-
seven years did not show any change.
sonal anxiety with predominance of obsessive thoughts and fears
To study the incidence of Dissociative Stupor and Posession in a psy-
is characteristic of patients with stable angina pectoris at ischemic
chiatry population. for ten years. To analyse the gender distribution
heart disease.
of different age groups and the predominant age of presentation.
Methods.– All new patients attending a private psychiatry OPD at
interest statement.
Lakhimpur Kheri, were screened for Dissociative Disorder accord-
ing to ICD 10, F44.2 and F44.3, from the 1st of JAN 2007 to 31st of
DEC 2016. These subjects, only those presenting with fits of uncon-
sciousness and possession, were analyzed and compared.
Results.– Out of a total of 48659 patients seen in this period (26943 Methods.– A cross-sectional, comparative study with 200 subjects
males and 21816 females) a total of 4372 presented with the above including 100 patients with hypertension and 100 matched con-
mentioned symptoms (879 males and 3493 females) about 8.98%. trols according to age and gender. Patient enrolment took place in
This confirms that 79.9% females represented the subject group but a basic health center in the governorate of Mannouba, Tunisia. Anx-
in preadolescent group, there were 205 males as compared to 163 iety and depression were assessed in both groups using the Hospital
females, a ratio of 1.26:1 in favour of males. Anxiety and Depression Scale (HAD-S).
Conclusions.– The results showed no decline. The study reconfirms Results.– In our study, 58% of patients with hypertension (n = 58)
that the symptoms are more prominent in adolescent and young had a certain anxiety with an anxiety score > 10 versus 22% of con-
females than males but this relationship is reversed in the preado- trol subjects (n = 22). The difference was highly significant between
lescent ages. the two groups (p < 0,001). As for the prevalence of depression,
The incidence of the select symptoms ranged between 7.6% and 27% (n = 27) of patients with hypertension had a certain depres-
10.2% through the 10 years, The figure would be much higher if both sion with a depression score> 10 versus 8% of control subjects
conversion and dissociative symptoms are included. The results of (n = 8). The difference was statistically significant between the two
this present study of fifteen years are yet to be analyzed. groups (p < 0.001). Twenty-four percent of patients with hyper-
Disclosure of interest.– The authors have not supplied a conflict of tension (n = 24) had both a certain anxiety disorder and a certain
interest statement. depression compared to 6% of patients (n = 6). The difference was
statistically significant (p < 0.001).
Conclusions.– Our results emphasize the high prevalence of anxiety
E-PP0013 disorders and depression in patients diagnosed with hypertension
Cognitive and behavioral compared to a control group. Nevertheless, these disorders are still
management of a woman with under-diagnosed in this population which highlights the need for
a systematic screening and an early management of these comor-
generalized anxiety disorder and
bidities.
multiple sclerosis Disclosure of interest.– The authors have not supplied a conflict of
F. Fekih-Romdhane* , U. Ouali, M. Cheour interest statement.
Razi Hospital, Psychiatry Department “Ibn Omrane”, manouba,
Tunisia
E-PP0015
Background and aims.– Among the therapeutic means proposed for Systematic information processing in
anxiety disorders, cognitive and behavioral therapies have a proven patients experiencing pathological
anxiolytic effect. The current study aimed to describe the cogni- worry. The role of loss avoidance and
tive and behavioral management of a female patient with severe inhibitory control
generalized anxiety disorder comorbid with multiple sclerosis. J. Gierus* , A. Szulc
Methods.– The clinical case presented in this study concerned a Clinic of Psychiatry- Medical University of Warsaw, Department of
42-year-old woman followed since 2007 for a severe relapsing- Health Sciences, Pruszków, Poland
remitting multiple sclerosis. In March 2018 she was diagnosed with * Corresponding author.
generalized anxiety disorder. The cognitive and behavioral therapy
took place over fifteen 45-minute weekly sessions. Initial, inter- Background and aims.– The presented work discusses the problems
mediate and final evaluations included the « Penn State Worry of connection of the intensification of pathological worrying with
Questionnaire » and the « Hamilton Anxiety Scale ». symptoms of anxiety, generalized anxiety, the use of systematic
Results.– During the course of the therapy, we observed a clini- information processing and heuristics.
cal improvement in the patient’s symptoms such a decreased of Methods.– The first phase of the study covered N = 251 subjects, a
anxiety intensity and frequency of worries and an improvement survey containing test items of the Penn State Worry Question-
in somatic complaints. The final evaluation showed that the objec- naire scale (PSWQ), questions about the frequency of consultations
tives formulated with the patient were achieved and that there was with the GP and the symptoms of generalized anxiety disorder
an important improvement of the different scales of evaluation. were used. In the second phase (N = 220) STAI Inventory, PSWQ
Conclusions.– cognitive and behavioral therapy is an interesting questionnaire and experimental tasks for measuring algorithmic
option in the treatment of generalized anxiety disorder, including and heuristic thinking were used (in two types of conditions: with
its severe and comorbid form with a disabling neurological disease emotionally neutral stimulus material and with anxiety-related
such as multiple sclerosis. connotations). In the third phase (N = 60) Iowa Gambling Task and
Disclosure of interest.– The authors have not supplied a conflict of the Stroop B, implemented in the Psytoolkit environment, were
interest statement. additionally applied.
Results.– 4.7% of respondents met the GAD criteria at the time of
the study. 61% of people declaring high levels of worries declared
E-PP0014 experiencing GAD symptoms during their lifetime. These people
Is there an association between visited the GP much more often. There were significant correlation
hypertension and both anxiety and connections between mood and worrying as well as anxiety and
mood and style of information processing. There was also a signifi-
depression?
cant correlation between the results of the Iowa Gambling Task test
S. Ellini1 , N. Ghazouani2* , Y. Jemli1 , R. Maamouri2 , M. Cheour1
1 and worrying in group of women.
Razi University Hospital, Psychiatry, Manouba, Tunisia; 2 Medical
Conclusions.– The obtained results suggest that anxiety and mood
School of Tunis, Psychiatry, Tunis, Tunisia
* Corresponding author. have significantly modified the style of information processing in
conditions of uncertainty. Among the subjects meeting the GAD
Background and aims.– Anxiety and depression are common psychi- criteria, there were more women, and among women, the intensity
atric comorbidities in patients diagnosed with hypertension which of worrying was related to the decision-making style oriented on
may worsen the course of this disease. loss avoidance.
The objective of our study was to evaluate the prevalence of anxiety Disclosure of interest.– The authors have not supplied a conflict of
and depression during hypertension in a tunisian cohort. interest statement.
E-PP0016 not subside with prescribed pharmacological treatment. After the

Impulsivity facets in generalized following studies significant findings of elevation of metanephrines
anxety disorder in blood and urine, and images of abdominal ultrasound and
C. Gitahy Falcao Faria* , R. Ferreira Garcia, R. Cristophe da Rocha scintigraphy with MIBG compatible with paraganglioma at the left
Freire infrarrenal location were found. It required surgical intervention
Federal University of Rio de Janeiro, Laboratory of Panic and with the paraganglioma being extirpated resulting in improve-
Respiration- Institute of Psychiatry, Rio de Janeiro, Brazil ments of her anxious disorder, but the depressive syntoms persist.
* Corresponding author. Conclusions.– Although Tako-Tsubo cardiomyopathy secondary to
pheochromocytoma is a very rare entity, it should be taken into
Background and aims.– mpulsivity has a pivotal role in several account in the differential diagnosis of anxiety disorders that do not
mental disorders; it has been identified as a significant pathologic respond to usual treatment, especially in postmenopausal women.
dimension in OCD, eating disorders, ADHD, addiction disorders It is estimated that about 47% of the patients with this pathology
and more recently, in bipolar disorder. However, few studies have present a previous story of psychiatric or neurological pathology
investigated the association between Generalized Anxiety Disor- and that 17.1% were medicated with one or more antidepressants.
der (GAD) and impulsivity. The aim of this study was to investigate The case shows the psychiatric aspects of the organic disease and
the possible relation among different impulsivity facets and clinical the diagnostic and therapeutic problems that arise when these are
characteristics of patients with GAD. the form of onset of the disease.
Methods.– 34 patients with GAD and 29 healthy volunteers were Disclosure of interest.– The authors have not supplied a conflict of
included. All subjects were accessed using the GAD-7, Penn State interest statement.
Worry questionnaire (PSWQ), Beck Depressive Inventory, and the
Barrat Impulsivity Scale (BIS - 11). Neuroticism was measured using
the five factor adjective list described by Hutz et al. (1998).
Results.– Global BIS-11 scores were higher in the GAD group, in
E-Poster Presentation: Anxiety Disorders and
comparison with controls (68.50 ± 10.97 vs 61.31 ± 9.07 p = 0.007). Somatoform Disorders - Part II
Only the facets of attentional impulsivity and cognitive instability
were significantly higher in groups. Cognitive instability was better
explained by higher PSWQ scores, while the attentional impulsivity E-PP0018
was better explained by higher GAD-7 scores, in linear models. Education as a moderator in the effect
Conclusions.– Higher global impulsivity in GAD patients seems to of diabetes on depressive symptoms in
be due to increased attentional impulsivity and cognitive instabil-
chinese middle-aged and older adults:
ity but not to increased scores in other impulsivity facets. Different
aspects of symptoms severity but not diagnosis explained impul- a population-based longitudinal study
sivity in both dimensions (attentional and cognitive). Y. Luo1 , D. Zhu2 , X. Shi3 , N. Stephen4 , P. He5*
1 Peking University, Institute of Population Research, Beijing, China; 2
interest statement. China Center for Health Development Studies, Peking University,
Beijing, China; 3 Beijing University of Chinese Medicine, School of
Management, Beijing, China; 4 University of Newcastle, Newcastle
E-PP0017 Business School, Newcastle, Australia; 5 Peking University, China
Broken heart disease and psychiatric Center for Health Development Studies, Beijing, China
patology: a case report
F.J. Gomez Beteta* , M. Villanueva Gallego, J. Ibañez Vizoso, J. Background and aims.– Co-morbid diabetes and depression is com-
Peman Rodriguez, C. Carrascosa Carrascosa mon; however, little evidence was regarding the effect of education
Instituto de Psiquiatria y Salud Mental del Hospital Clinico San on this association. This study aimed to investigate the role of edu-
Carlos, Psychiatry, Madrid, Spain cation in the effect of diabetes on depressive symptoms in China.
Methods.– We used data from the China Health and Retirement Lon-
gitudinal Study, including 6,921 participants free from depressive
Background and aims.– Highlight the importance of performing an
symptoms in three waves of cohort study from 2011 at baseline in
organic screening before diagnosing panic attacks, especially in the
2011–2012. We assessed the depressive symptoms based on Cen-
cases of refractoriness.
ter for Epidemiological Studies–Depression scale. We fitted Cox
Methods.– The case of a 58-year-old woman diagnosed with
proportional hazards regression models to examine the effect of
anxiety-depressive disorder, refractory to antidepressant and anx-
baseline diabetes on the subsequent depressive symptoms.
iolytic treatment was presented.
Results.– Participants with diagnosed diabetes were more likely
Results.– In the Emergency Service, it was detected that elevated
than their non-diabetic peers to develop depressive symptoms only
numbers of myocardial damaging enzymes and echocardiographic
in 45–64 years group, with a hazard ratio of 1.30 (95% CI: 1.05, 1.61).
alterations existed which were studied in the Department of Car-
In addition, the effect of diagnosed diabetes on depressive symp-
diology and diagnosed as Sd. Takotsubo. During follow-ups at a
toms only occurred in participants with a diploma of primary school
Psychiatry clinic, it was observed that the symptoms of anxiety per-
or below (table 1).
sist such as nausea, tachycardia, sweating, and dizziness which do
Table 1. Hazard ratio of elevated depressive symptoms in mid-aged phenomenon that manifests the collapse of the mind in front of
and older adults, by diabetes the psychic suffering. One hundred years after Charcott and Freud,
these phenomena are still observed.
interest statement.
E-PP0020
Rapid orienting to masked angry faces
in social anxiety disorder
P. Holas1* , L. Zurawski2
1 University of Warsaw, Psychology, Warsaw, Poland; 2 The Nencki
Institute of Experimental Biology, Laboratory of Psychophysiology,
Warsaw, Poland
Background and aims.– Biases in information processing play an

important role in the etiology and maintenance of anxiety dis-
orders. Social anxiety disorder (SAD) is marked by fear of social
interactions and includes a hypersensitivity to signals of social
threat, such as angry facial expressions. A number of functional
imaging studies have reported anomalies in responses of the amyg-
dala in social anxiety, however, little is known about the behavioral
impact of the amygdala sensitivity to masked angry faces in social
Conclusions.– Our findings suggested that diagnosed diabetes was anxiety.
a chronic stressor in developing depressive symptoms, and that Therefore, the aim of the present study was to evaluate if the amyg-
response to this stressor varied by individuals’ educational attain- dala is involved in rapid orienting to backward masked angry faces
ment. Action to prevent and treat diabetes may contribute to in social anxiety.
the fight against depressive symptoms, especially in the lower- Methods.– With event-related functional magnetic resonance
education population. imaging, brain activation to backward masked angry faces pho-
Disclosure of interest.– The authors have not supplied a conflict of tographs was measured in 18 individuals with SAD and 18 healthy
interest statement. subjects, as a control group. During imaging, subjects performed
a dot-probe task with rapidly presented (33 msec), masked emo-
tional (angry) and neutral faces (direct trails) or undirected trials
E-PP0019 consisted of either two angry or two neutral faces.
Results.– We found faster response to subliminally presented angry
Regression and recovery in conversion
faces in both studied groups, when face was presented on the right
disorder. video presentation of a case visual field (RVF) accompanied by increased right amygdala acti-
of hysteria in the 21st century vation. Compared with control subjects, socially anxious showed
G. Hernandez-Santillan* , A. F. Visedo, M. Dieguez-Porres greater response of amygdala to all kinds of pair of faces.
University Hospital Principe de Asturias, Psychiatry, Madrid, Spain Conclusions.– Results of the current study provide an evidence that
amygdala is involved in orienting to backward masked angry faces
and suggest that in socially anxious patients amygdala is hypersen-
Background and aims.– The conversion disorder is a functional
sitive not only to angry but also neutral faces.
neurological symptoms disorder without neurological or medical
conditions.
interest statement.
Methods.– Description and two-minute video presentation of a case
plus literature review.
Results.– A 51-year-old woman is evaluated in Psychiatry derived E-PP0021
from Neurology for episode of aphasia-like episode, weakness,
Quality of life, self-stigma and coping
gait disorder, during less than 48 hours and anodyne results of
transcranial doppler ultrasound and brain scan. She was born in strategies in patients with neurotic
Eastern Europe but have lived in Spain during 20 years. When she spectrum disorders – a cross-sectional
was 27, her little child was severely ill while her husband was study
moved abroad and she required a Psychology consultation for a M. Holubová1,2* , J. Praško2 , M. Ocisková2 , K. Kantor2 , J. Vaněk2 , M.
year. Before the current episode, she had visited the Urgency three Šlepecký3 , K. Vrbová2
times due to dissociative amnesia and ataxia in stressful moments 1 Regional Hospital Liberec s.r.o, Department of Psychiatry, Liberec,
with spontaneous resolution. The actual episode is similar, but Czech Republic; 2 Faculty of Medicine and Dentistry- Palacky
with additional language disorder as babbling, incongruent affec- University Olomouc- University Hospital Olomouc, Department of
tion, puerile behavior and child’s writing suggestive of an infantile Psychiatry, Olomouc, Czech Republic; 3 Faculty of Social Science and
evolutionary state compatible with regression. Treatment with Health Care- Constantine the Philosopher University in Nitra,
benzodiazepines and haloperidol was effective. On the third day Department of Psychology Science, Nitra, Slovak Republic
she had intelligible and coherent speech, with dissociative amne- * Corresponding author.
sia, although she still continued puerile. She continued treatment

in home hospitalization and she evolved from childhood to adult Background and aims.– Modern psychiatric view focuses on the
life after two months of treatment until she recovered her normal QoL, self-stigma, and coping strategies. Maladaptive coping may
functionality. It was used integrative psychotherapy as well. adversely disturb the overall functioning, and self-stigma is con-
Conclusions.– Conversion disorder was called “hysteria” before and, sidered to have a negative impact on many areas of patient’s life.
despite the pejorative connotation of the term, it is a non-conscious This study examined the relationship between demographic data,
the severity of symptoms, self-stigma, coping strategies, and QoL disorders — the major pathogenetic factor is represented by health
in patients with neurotic spectrum disorders. anxiety.
Methods.– A total of 153 clinically stable outpatients, who met Disclosure of interest.– The authors have not supplied a conflict of
the ICD-10 criteria for neurotic spectrum disorders, were enrolled interest statement.
in the study. Psychiatrists examined outpatients during regular
checkups, where they fulfilled SVF-78, ISMI, Q-LES-Q, and CGI. Cor-
relations and multiple regression analyses were performed. E-PP0023
Results.– The neurotic spectrum diagnostic subgroups, which Anxio-depressive disorders in patients
included (1) panic disorder and/or agoraphobia; (2) social phobia; in complete remission of breast cancer
(3) generalized anxiety disorder and mixed anxiety-depression dis- N. M’hedhbi1 , B. Manel1 , L. Jouini1* , M.A. Ayadi2 , W. Homri3 , L.
order; (4) adjustment disorder; (5) somatoform disorders; and (6) Raja3
obsessive compulsive disorder, - differ significantly in age and use 1 Razi hospital, psychiatry department A, Mannouba, Tunisia; 2 Salah
of negative coping, but not in other clinical variables. No differ- Azaiez Institute, Outpatient Surgical Oncology department, Tunis,
ence between both sexes in relation to the severity of the disorder, Tunisia; 3 Razi hospital, psychiatry department C, Mannouba, Tunisia
self-stigma, positive coping and QoL were found. The QoL corre- * Corresponding author.
lates significantly with all coping strategies, except Guilt denial.
Regression analysis showed the most significant factors to be pos- Background and aims.– Breast cancer and its treatment may cause
itive coping, employment, and self-stigma, explaining 32.9% of the physical and psychic aftereffects. Psychological symptomatology
QoL. The most significant factors connected to the self-stigma, were may include anxious and depressive manifestations. The aim of the
subjective CGI, positive coping, and the QoL, which explained 44.5% study was to estimate the prevalence of anxiety-like and depressive
of the ISMI. psychiatric disorders in patients in complete remission from non-
Conclusions.– The study confirmed the relationship between the metastatic breast cancer.
quality of life, self-stigma, the severity of the disorder, and the Methods.– We conducted a prospective descriptive cross-sectional
coping strategies of outpatients with neurotic spectrum disorders. study. This study randomly involved 50 patients in remission of at
Disclosure of interest.– The authors have not supplied a conflict of least 3 months of non-metastatic breast cancer followed at outpa-
interest statement. tient surgical oncology department at the Salah Azaiez Institute,
having consulted for a period ranging from April to June 2017.
Screening for anxiety and depression was assessed using the Hos-
E-PP0022 pital Anxiety and Depression Scale (HADS).
Transition from perception of Results.– The average age was 54 years old. Socio-economic level
autonomic functioning to was rather medium to low. The majority of patients, 84%, did not
go beyond the primary level and 88% were without a profession.
somatoform disorders: the role of Half of the population was married. The average consultation time
alexithymia and health anxiety was 9 months. The average duration of remission of the patients
G. Arina1 , P. Solodchik1 , M. Iosifyan1* , O. Dobrushina2 was 20 months. At the time of diagnosis, 78% of the patients were at
1 Moscow State University, Department of Psychology, Moscow, an early stage. Breast surgery was conservative in 44% of cases and
Russia; 2 Research Center of Neurology, Third neurological radical in 56% of cases. Adjuvant chemotherapy was administered
department, Moscow, Russia in 78% of cases. Thirty-four percent of patients (N = 17) had anxiety
and 28% (N = 14) had depression. The need for psychological help
was halved during remission.
Background and aims.– Perception of autonomic functioning, such
Conclusions.– A multidisciplinary psycho-oncological management
as feeling of fast/loud heartbeat, sweatiness, bowel motility, is a
involving surgeon-carcinologist, oncologist, psychiatrist and psy-
part of normal interoceptive experience. However, the same fea-
chologist is necessary for patients in remission of breast cancer.
tures represent the complaints forming somatoform disorders. It is
of practical importance to study the differences between these two
interest statement.
phenomena.
Objectives.– To evaluate the factors contributing to increased auto-
nomic perception and to formation of somatoform disorders. E-PP0024
Methods.– 58 volunteers aged 38 ± 12 (7 male) were examined Female sexual dysfunction in anxiety
with the use of Screening for Somatoform Disorders 2 (SOMS-
2), Autonomic Perception Scale (APS, a checklist for features of
patient
M. Khan Bhadar
autonomic functioning perceived during the last week), Short
Sexual Health Institute of Pakistan, Psychiatry, Lahore, Pakistan
Health Anxiety Inventory (SHAI), Toronto Alexithymia Scale (TAS-
Background and aims.– Female anxiety patient can have different
20), and Multidimensional Assessment of Interoceptive Awareness
sexual dysfunctions. There is bilateral relationship between anxiety
(MAIA). A linear regression was used to evaluate the role of
and female sexual dysfunction. All four phases of sexual responses
alexithymia, health-related anxiety and interoceptive awareness
get effected by anxiety. It has impact on autonomic nervous system
both in autonomic perception (APS) and in somatoform disorders
involved in sexual response. Women with anxiety has arousal or
(SOMS-2)
orgasmic dysfunction. SSRIs are used extensively for anxiety dis-
Results.– Linear regression allowed prediction of the APS value
order can cause serious sexual dysfunction. Pharmacotherapy of
on the base of model including TAS-20, SHAI and MAIA (R = 0.75,
anxiety without SD is challenging task.
p < 0.001), and the major predictor was alexithymia (standard-
Methods.– Pub med reasech was made using key words female sex-
ized coefficient 0.7, p < 0.001). Model with the same components
ual dysfunction, SSRI,s anxiety.
allowed prediction of the SOMS-2 value (R = 0.73, p < 0.001),
Results.– Anxiety disorders are twice as high in female population.
but, in contrary with the APC value, the major contributor
Female with anxiety can have 3.5 time more orgasmic or arousal
was the health-related anxiety (standardized coefficient 0.6,
disorder than non anxious patients. In patients taking SSRI,s all
p < 0.001).
phase of sexual responses but in particular arousal in female.
Conclusions.– Individuals with higher alexithymia are prone to
Conclusions.– Sexual dysfunction in female on antidepressant are
increased perception of autonomic signs, which may be explained
troublesome which might become cause for non adherence. There
by inability to recognize the emotional content of arousal. How-
are many strategies to combat this problem. Add on medication
ever, alexithymia per se does not lead to formation of somatoform
to counter these side effects. These include buspiron, and bupro- Background and aims.– The aim of this study was to analyze the
pion. There are medicine that are effective on anxiety but have effect of anxiety on dental fear in adult dental patients.
minimum side effects. These medicines include vilazedone, vor- Methods.– This is a Descriptive correlational study and its design
tioxetine, mirtazepine, agomelatine, thianeptine, buspiron. 5HT1a was Cross – Sectional Study or Time. On a six month research 114
as a receptor as oppose to 5HT2a and 5HT2c does not cause sex- adult dental patients (58 with exacerbation of the clinical picture
ual Vilazedone, vortioxetine and buspiron act on it. Mirtazepine an of periodontal disease and 56 with good dental hygiene) filled in
agomelatine are antagonist at 5HT2 and have anti anxiety effect a questionnaire consisted of three parts: a) a form with individual
with less SD. Thianepine act via dopamine,is devoid of SD. Bupro- characteristics, b) the MDAS and c) the STAI of Spielberger. The
pion act on dopamine and nor adrenaline so can undo SSRI induced study took place in a private dental office in Larissa (Greece).
SD. Non pharmachological modality include CBT, relaxation exer- Results.– There is a relationship between stress and dental fear. The
cises, water therapy can be used. results from STAI shows that an increase in total anxiety by one unit
Disclosure of interest.– The authors have not supplied a conflict of caused an increase in total dental fear by 0,048 units (p = 0,011), in
interest statement. transient anxiety by 0,083 (p = 0,011) while permanent anxiety was
not statistically significant.
Conclusions.– Stress and dental fear are interrelated, creating prob-
E-PP0025 lems for both the health and daily routine of patients. The dental
The change of heart rate variability team must be able to understand psychological signs and be in
during 6-week pharmacotherapy in constant co-operation with other health professionals to reduce
anxiety and dental fear so as to increase the vital level of patients
patients with panic disorder
as well as to promote public health.
W. Kim
Seoul Paik Hospital- College of Medicine- Inje University, Psychiatry,
interest statement.
Seoul, Republic of Korea
Background and aims.– Autonomic nerve system is closely related
with panic symptoms and heart rate variability (HRV). This study
was designed to evaluate relation between 6-week pharmacother- E-Poster Presentation: Anxiety Disorders and
apy and the alteration of autonomic nerve function in patients with
Somatoform Disorders Part III
panic disorder.
Methods.– The subjects were patients (n = 44) who met DSM-IV
criteria for panic disorder with or without agoraphobia. They per-
E-PP0027
formed ADIS-P&A, CGI, HAM-D, PDSS and heart rate variability
before and after 6-week pharmacotherapy. We prescribed paroxe- A review of neurological soft signs in
tine primarily and benzodiazepine in case of needed. obsessive compulsive disorder
Results.– After 6-week pharmacotherapy, panic symptoms A. Krupa1* , A. Chrobak2 , M. Siwek3
1 Jagiellonian University Medical College, Students’ Scientific
were significant improved. In the power spectrum analysis of
HRV, Total Power (TP) was significantly reduced after treat- Association of Affective Disorders, Cracow, Poland; 2 Jagiellonian
ment (F(1,43) = 2.83, p = .007). Low Frequency variables were University Medical College, Department of Adult Psychiatry, Cracow,
reduced after 6-week treatment. [LF (F(1,43) = 2.16, p = .036), nLF Poland; 3 Jagiellonian University Medical College, Department of
(F(1,43) = 2.31, p = .026)]. And LF/HF ratio has the trend of decre- Affective Disorders, Cracow, Poland
ment, although not statistically significant (F(1,43) = 1.70, p = .096).
The change of TP (r = −.414, p = .006), log TP (r = −.375, p = .013),
and log HF (r = −.339, p = .026) showed significant correlation with Background and aims.– There is a significant amount of research
symptom improvement. In addition, stepwise regression analysis focusing on neurological soft signs (NSS) as an endophenotype
is performed to find out the HRV parameters most predictable of schizophrenia spectrum disorders (SZ) and their importance in
to patients’ improvement. The change of TP were most powerful bipolar disorder (BD) was discussed, however the research focussed
predictor of patient’s improvement by indicating 15.8% (p = .008). on obsessive compulsive disorder (OCD) has not been thoroughly
Conclusions.– After 6-week treatment, HRV analysis showed that explored yet. The aim of this presentation is to review the literature
sympathetic variables (LF, nLF, and log LF) were significantly existing in the field on NSS in OCD.
reduced, while parasympathetic variable (nHF) were significantly Methods.– The PubMed database was searched up to February 2018
increased. Thus, the results suggest that the improvement of panic using the phrase “neurological soft signs” and “OCD”. Only origi-
symptoms is related with increment of parasympathetic system nal papers in English, which investigated patients with OCD were
and decrement of sympathetic system. In addition, these results selected, resulting in inclusion of 31 studies.
also suggest that the change of TP were most powerful predictor of Results.– The vast majority (21 out of 23) of studies comparing
the improvement of panic symptoms. patients with the diagnosis of OCD to healthy controls confirmed
Disclosure of interest.– The authors have not supplied a conflict of higher NSS scores in patients, with 2 studies showing no signif-
interest statement. icant difference. Participants with OCD comorbid with psychosis
showed increased NSS when compared to those with OCD only,
as described by 6 papers. Studies showed similar NSS scores in
E-PP0026 siblings of patients with OCD and healthy controls. Moreover,
The effect of anxiety on dental fear in patients with OCD with poor insight were shown to have higher NSS
scores than those with good insight. Those with OCD and increased
adult dental patients in Greece left-visuospatial dysfunction were less likely to respond to phar-
G. Tsioumanis1 , E. Kotrotsiou1 , T. Paralikas1 , S. Kotrotsiou1* , K.
macological treatment than those without it. The higher levels of
Tsaras1 , M. Malliarou1 , E. Nanas2 , C. Barbouta1 , A. Barbouta3
1 University of Applied Sciences of Thessaly. T.E.I. of Thessaly. NSS were associated with more severe symptomatology and neu-
ropsychological deficits.
Postgraduate Program in Mental Health. Laboratory of Care., Nursing,
Conclusions.– NSS presence is confirmed not only in SZ or BD but
Larissa, Greece; 2 Dental Home Larissa, Dental Home Larissa, Larissa,
also OCD. The literature suggests that increased NSS scores are
Greece; 3 Uninersity of York. Msc Psychology of Education, Education,
related to more severe OCD symptoms and neuropsychological dys-
York, United Kingdom
* Corresponding author. functions.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Thirty-two healthy male participants were recruited for
interest statement. this study. During the image acquisition, participants were asked
to judge how badly they felt to negative sentences like “I hope that
will be in a terrible car accident” with the name of a close
E-PP0028 ore neutral person (CP or NP condition). A functional image data
Highly anxious panic patients avoid were obtained the 3.0T GE 750W scanner with 24ch head coil.
risk-taking behavior? The SPM8 was used in fMRI data image processing and statistical
K.U. Lee analyses.
College of Medicine- The Catholic University of Korea- Seoul- Korea, Results.– Participants felt more uncomfortable and completed eval-
Psychiatry, Seoul, Republic of Korea uation more quickly to the negative sentences with close persons
Background and aims.– We aim to experimentally examine how than those with neutral persons. Common activations in both con-
individuals with panic disorder (PD) and healthy controls (HC) ditions were observed in bilateral lingual gyri, left middle and
show risk-taking behaviors when exposed to negative emotional inferior frontal gyrus, superior medial frontal gyrus, precuneus and
stimuli. bilateral caudate nuclei (Figure 1) while no statistically significant
Methods.– 18 patients with PD and 14 healthy volunteers partici- difference was found between the CP and NP condition. Further,
pated in this study. Participants were exposed to 6 pictures with activities in these regions generally showed positive correlations
negative valence which were selected from the IAPS. The pictures with baseline total and dimension scores of obsessive-compulsive
were presented for 60 seconds, 10 seconds each to induce nega- symptoms.
tive emotion on the computer screen. Next, participants conducted Conclusions.– Here, we demonstrated neural correlates of TAF and
the Balloon Analogue Risk Task which is a computerized program verified these findings based on previous studies related with
to measure risk-taking behavior. In the task, a participant pumps imagery, mentalizing, empathy for social pain, guilt, emotion reg-
the presented balloon up by pushing a keyboard button. Each pump ulation and salience network.
inflates the balloon incrementally and points are accumulated until Disclosure of interest.– The authors have not supplied a conflict of
some uninformed thresholds at which the balloon explodes. We interest statement.
used two variables from the task: the adjusted mean pumps (AMP)
which excludes exploded balloon and the within-subject intertrial
E-PP0030
variability of pumps at “cash out” divided by AMP (VARAMP).
Results.– Both groups did not show significant differences in BDI, Effect of tramadol on corticosteroid
STAI, AMP, and VARAMP. However, correlation analysis revealed receptor function in patients with
reverse relationships in two groups. There were significant negative major depression
correlation between SAI and VARAMP in PD (r = −.590, p = .01) and S. Minenko
significant positive correlation in HC (r = .726, p < .01); significant Sergei Minenko, Lvov Psychiatric Hospital, Lvov, Ukraine
negative correlation between TAI and VARAMP in PD (r = −.529, Background and aims.– The goal of current study was- to test the
p < .05) and significant positive correlation in HC (r = .561, p < .05). influence of the opioid, adrenergic and benzodiazepine drugs on the
Conclusions.– The present study suggests different modulating immunosuppressive levels of leukocyte pyruvat dehydrogenase
functions of anxiety for risk-taking behaviors in panic disorder and activity (LPDG) during the DST in patients with Major Depression
healthy control. That is, high state anxiety in patients with panic and Anxiety Disorder.
disorder may increase self-control over risk-taking behavior. Methods.– Patients 40 male/mean age, 33,1 + 3,2 years/ and 20 pre-
Disclosure of interest.– The authors have not supplied a conflict of menopausal female /35,1 + 1,6 years/ patients with Primary Major
interest statement. Depressive Episode were studied. The DST was conducted to 60
patients with Primary Depressive Episode and 30 healthy sub-
jects /30 patients with an Anxiety Disorder - comparison subjects/.
E-PP0029 Criteria of the DST estimation included the degree of immunosup-
Neural correlates of thought-action pression on LPDG activity after L-Dopa, Tramadol (opioid-like drug)
fusion using a conventional and Diazepam administration.
thought-action fusion task in healthy Results.– In cases of Primary Major Depressive Episode in separation
with Anxiety Disorder after TRAMADOL and DIAZEPAM adminis-
adults
tration activity of LPDG increased more than 25%. TRAMADOL of a
S.J. Lee1* , S.W. Lee1 , H. Cha2 , Y. Chung1 , E. Kim2 , M. Choi3 , S.
50 mg dose and DIAZEPAM of a 10 mg dose had a higher immuno-
Huijin3 , Y. Chang4
1 Kyungpook National University School of Medicine, Department of suppressive effect than L-DOPA /0,5 g/ on alteration of LPDG activity
/more than 5 mmol/l/hour, p 0,05/.
Psychiatry, Daegu, Republic of Korea; 2 Kyungpook National
Conclusions.– TRAMADOL immunosuppressive action was higher
University School of Medicine, Department of Medical and Biological
than L- DOPA and DIAZEPAM on LPDG activity in patients with an
Engineering, Daegu, Republic of Korea; 3 Kyungpook National
Anxiety Disorder and Major Depression. Diazepam immunosup-
University School of Medicine, Institue of Biomedical Engjneering
pressive action did not correlate with positive dynamics of LPDG
Research, Daegu, Republic of Korea; 4 Kyungpook National University
levels of DST in patients with Anxiety Disorder (after the 4–5 th
School of Medicine, Department of Radiology and Molecular
week of Diazepam treatment). From other side, mechanism of L-
Medicine, Daegu, Republic of Korea
* Corresponding author. Dopa action on corticosteroid receptors stimulated LPDG-activity
(L-Dopa therapeutic effective dose-3 g). It means that opiate, adren-
Background and aims.– Thought-action fusion (TAF) is a general cog- ergic and benzodiazepine receptors are interacting with each other
nitive tendency of people to believe that a thought is like an action and influencing on the corticosteroid receptors in different ways
which are thought to contribute to develop obsessional phenom- during immunosuppression.
ena. However, there has been only a few studies demonstrating TAF Disclosure of interest.– The authors have not supplied a conflict of
associated neural mechanism. This fMRI study aimed to investigate interest statement.
the hemodynamic responses of TAF evoked by a conventional TAF
paradigm and their relationships with psychological measures.
E-PP0031 ideation. The aim of the current study was to evaluate the relation-
Do we have to worry about mental ship between suicidal ideation and somatic symptoms declared by
and physical health of our residents? patients with neurotic, behavioral or personality disorders.
R. Navinés De La Cruz1* , E. Gelabert2 , V. Olivé3 , L. Macías4 , J. Methods.– KO “O” Symptom Checklist and Life Inventory completed
López5 , J. Ariz5 , M. Tortajada6 , E. Gómez-Gil7 , R. Martín-Santos1 by a group of 680 patients treated for the first time at the daily
1 Hospital Clínic- UB- IDIBAPS- CIBERSAM, Psychaitry and psychotherapeutic ward between 2005 and 2013.
Psychology, Barcelona, Spain; 2 Faculty of Psychology- Universitat Results.– There were statistically significant positive correlations
Autònoma Barcelona, Psychology and Health, Barcelona, Spain; 3 between suicidal ideation and severity of somatic symptoms
Hospital Clínic and University of Barcelona Faculty of Medicine, assessed with a collective subscale of KO “O” Symptom Checklist
Preventive Service Occupational Risks, Barcelona, Spain; 4 Hospital (p < 0.001), as well as with some particular somatic symptoms, such
Clínic, Biochemical and Molecular Genetics, Barcelona, Spain; 5 as loss of appetite (p < 0.001) and hunger pangs (p < 0.001) in men
Hospital Clínic, Preventive Service Occupational Risks, Barcelona, and hunger pangs (p < 0.001) and fainting (p < 0.001) in women.
Spain; 6 Hospital Clinic, Preventive Service Occupational Risks, Conclusions.– The obtained results allow to conclude that in
Barcelona, Spain; 7 Hospital Clínic, Psychiatry and Psychology, patients with neurotic, behavioral and personality disorders sui-
Barcelona, Spain cidal ideation significantly relate to certain somatic symptoms,
* Corresponding author. particularly with gastrointestinal symptoms and those occurring
in eating disorders. Further research is necessary to determine the
Background and aims.– A recent update has indicated a high direction of causal relationships between these symptoms.
association between work stress and the debut of metabolic syn- Disclosure of interest.– The authors have not supplied a conflict of
drome, cardiovascular diseases and burnout syndrome (Navinés interest statement.
et al.,2016). Residents in training are a particularly vulnerable group
(Chaukos et al., 2017).
To evaluate changes in physiological, biochemical parameters, and E-PP0033
emotional distress, perceived stress, and burnout scores after the Validity and reliability of the perinatal
first year of the residency training program. anxiety screening scale in a
Methods.– Design: A prospective cohort study, 12 months follow- portuguese sample of pregnant
up, with evaluation in two points (baseline and 12 m). Subjects:
First year trainees who gave the informed consent. The study
women
A.T. Pereira1* , C. Pinto2 , J. Azevedo1 , C. Marques1 , S. Xavier1 , M.J.
was approved by the ERC. Setting: General Hospital. Assessment:
Soares1 , M. Marques1,3,4 , A. Macedo1,4
Socio-demographic, physiological (BMI, blood pressure); biochem- 1 Faculty of Medicine - University of Coimbra, Institute of
ical: glycemia, cholesterol, triglycerides; clinical: medical history,
Psychological Medicine, Coimbra, Portugal; 2 Coimbra University,
GHQ-28, Perceived stress scale (PSS) and Maslach Burnout Inven-
Faculty of Medicine, Coimbra, Portugal; 3 Miguel Torga Higher
tory (MBI).
Institute, Miguel Torga Higher Institute, Coimbra, Portugal; 4 Hospital
Results.– Participants: We selected 69 trainees (75%), and 57(62%)
and University Centre, Psychiatry Department, Coimbra, Portugal
were included, with a mean (SD) age:25.5(3.2) years old. Seventy * Corresponding author.
percent were doing a medical speciality, and 24% had a history
of anxiety/depression. At baseline: We only observed some degree Background and aims.– Although distinguishing normal and patho-
of perceived stress. At 12-months: a) Increase of diastolic pres- logic anxiety is particularly difficult in the perinatal period, anxiety
sure 78.3(6.6)/72(8.4); p = 0.000), BMI:21.9(2.8)/22 (3); p = 0.006), disorders affect approximately 10% of the women in this period.
and triglycerides: 86 (51)/71 (29); p = 0.070). b) 22% met metabolic The evidence that perinatal anxiety leads to negative outcomes for
syndrome criteria; c) 20% had emotional distress and burnout family as a whole highlights the need for its early identification. To
syndrome; d) 20% showed higher emotional exhaustation: 12.2 our knowledge there is only one instrument which items take into
(8.4)/8.9 (7.8); p = 0.047) and depersonalization scores: 3.7 (4.3)/2 account this specific period, the Perinatal Anxiety Screening Scale
(2.5); p = 0.017), and a decrease of personal accomplishment scores: (PASS; Somerville et al., 2014).
39(7.7)/42(4.7); p = 0.034). Objectives.– To study the psychometric properties of the PASS Por-
Conclusions.– After the first year of the residency training pro- tuguese version, in pregnancy: factor structure using confirmatory
gram it was observed a significant increment in the frequency of factor analysis (CFA), internal consistency and correlations pattern
metabolic syndrome together with higher perceived stress and with other psychological distress constructs.
burnout scores. Methods.– 350 women (Mean age: 32.18 ± 5.246) in the second
Grant.– Fundación Prevent XI:DN040611(IP: Olivé, Navines) and trimester of pregnancy (Mean weeks of gestation = 17.13 ± 4.929)
the support of:SGR2017/1798(IP:Martín-Santos). completed the PASS, the Perinatal Depression Screening Scale
Disclosure of interest.– The authors have not supplied a conflict of (PDSS-24) and the Profile of Mood States (POMS-27). SPSS and
interest statement. AMOS software were used.
Results.– After deleting two items (1 and 2) and some errors
were correlated, CFA indicated a good fit for the second-
E-PP0032
order factor (X2 /df = 2.302; CFI = 0.913; GFI = 0.864, RMSEA = 0.061;
Somatic symptoms and the presence p[rmsea ≤ 0.01] < 0.001). The Cronbach alpha for the PASS 29 items
of suicidal ideation in patients with version was ˛ = 0.937, and for the four dimensions, the alphas were
neurotic, behavioral or personality all ˛ > 0.790. PASS total and dimensional scores were moderately
to highly correlated with perinatal depressive symptoms and with
disorders
both negative affect dimensions (Depression, Anxiety).
A. Ostachowska* , P. Rodziński, K. Rutkowski, E. Dembińska, A.
˛ Conclusions.– The PASS Portuguese version has good construct and
Citkowska-Kisielewska, J. Sobański, M. Mielimaka
convergent validity and reliability. In the near future we will deter-
Jagiellonian University Medical College, Department of
mine the PASS cut-offs with the best combination of sensitivity
Psychotherapy, Kraków, Poland
* Corresponding author. and specificity to screen for anxiety disorders in pregnancy and
postpartum.
Background and aims.– Somatic symptoms are common for anx- Disclosure of interest.– The authors have not supplied a conflict of
iety and personality disorders which are predictors of suicidal interest statement.
E-PP0034 Hospital Vrapce during 2017 and 2018. Examination included

The risk factors for dementia and detailed clinical interview with patients and their relatives, blood
affective disorders in middle-aged tests, psychological testing and neurological examination.
Results.– The diagnosis of conversion disorder often presents a
people with metabolic syndrome clinical challenge due to a wide range of symptoms that can
V. Piotrovskaya1* , N. Neznanov2
1
be misleading and considered as a part of other mental, neuro-
First State Pavlov Medical University, Psychiatry, St. Petersburg,
logical or somatic disorder. Motor dysfunction and psychogenic
Russia; 2 Federal State Budgetary Institution “National Medical
non-epileptic seizures are the most common among conversive
Research Centre of psychiatry and neurology named after V.M.
symptoms. Other important symptoms include sensory symptoms
Bekhterev”, Federal State Budgetary Institution “National Medical
(e.g. apparent loss of all modalities of sensation in limbs) and alex-
Research Centre of psychiatry and neurology named after V.M.
itimia.
Bekhterev”, sankt petersburg, Russia
Conclusions.– In cases of patients in emotional crises who present
with neurological symptoms that seem to be inconsistent or incom-
Background and aims.– Metabolic syndrome (MS) is associated with patible with known neurological and somatic diseases, conversion
an increased risk of developing dementia and affective disorders. disorder has to be considered as a possible differential diagnosis.
Also the endocannabinoid system has been involved in the regu- As soon as the organic background of the symptoms is excluded,
lation of anxiety. We examined the associations of components of it is necessary to start psychotherapy treatment. Shorter duration
MS with mild cognitive impairment (MCI), and anandamide (AEA), of symptoms, emphatic approach and confindence in positive out-
2-arachidonoylglycerol (2-AG), with anxiety (A) in middle age sub- come are considered to be good prognostic factors in the treatment
jects. of patients with conversion disorders.
Methods.– The data collected from 271 patients with MS (aged Disclosure of interest.– The authors have not supplied a conflict of
30–60 years) in Federal Research Program of Cardiovascular Dis- interest statement.
eases Risks,have been analyzed. Current MCI was confirmed
according to the criteria of ICD-10. Patients passed through: MMSE
E-PP0036
test, Wechsler memory scale, Hospital Anxiety and Depression
scale (HADS). lipid spectrum testing completed with «Abbott» The analysis of the relationship
kits. To assess the results the NCEP criteria were used. Level of between obsessive compulsive
endocannabinoids was determined by chromatography-mass spec- disorder and emotional
trometry. responsiveness and emotion
Results.– 271 subject were divided into 2 groups, group A – with
A and MCI (212 subjects) and the group B -without A (49 sub-
regulation in children and adolescents
I. Seçer1* , M. zaferoğlu2
jects). Using the Mann-Whitney test significantly strong connection 1 Ataturk University, Department of Psychology, erzurum, Turkey; 2
between high levels of total cholesterol,cholesterol low density
Atatürk University, Psychology, erzurum, Turkey
lipoprotein LDL-C, lipoproteins of very low density (VLDL) and MCI * Corresponding author.
in group A were obtained. Optional subjects with sings of MS and
MCI had a fairly high level of VLDL and LDL-C in comparison with Background and aims.– In this study, it was aimed to determine
subjects without MCI. Level of 2-AG significantly different in anx- the predictive relationships between emotional responsiveness
ious patients with MS. and obsessive-compulsive symptoms and to investigate whether
Conclusions.– There is link between MCI and components of MS, emotional regulation processes mediate the relationship between
Increasing in the level of LDL and VLDL can provoke MCI in emotional responsiveness and obsessive-compulsive symptoms.
middleage subjects with MS. MS activates ECS that triggers the Methods.– Descriptive survey model was used in the study. In this
development of cognitive impairment and anxiety direction, a structural equation model was used to determine pre-
Disclosure of interest.– The authors have not supplied a conflict of dictive and mediating relationships between obsessive-compulsive
interest statement. symptoms, emotional regulation processes and emotional respon-
siveness.
Results.– In the study, it was determined that obsessive-compulsive
E-PP0035
symptoms in high school students significantly differ in terms of
Difficulites in diagnostics and gender and school type variables, whereas they don’t show a sig-
treatment of conversion disorder- nificant difference in terms of age variable. It was also found that
experiences from Croatia emotional responsiveness predicts obsessive-compulsive symp-
T. Sabo1* , D. Bosnjak Kuharic2 , T. Cervenjak3 , A. Bacekovic1 , T. toms negatively and at a significant level, and emotional regulation
Jendricko4 processes mediate the relationship between emotional responsive-
1 University Psychiatric Hospital Vrapce, Department for Affective ness and obsessive-compulsive symptoms.
disorders, Zagreb, Croatia; 2 University Psychiatric Hospital Vrapce, Conclusions.– As a result, it was determined that emotional
Department for Diagnostics and Intensive Care, Zagreb, Croatia; 3 regulation skills mediate the relationship between OCD symp-
General County Hospital Vinkovci, General department, Vinkovci, toms and emotional responsiveness, and that OCD symptoms
Croatia; 4 University Psychiatric Hospital Vrapce, Department for in adolescents differ according to gender and school type. With
Psychotherapy, Zagreb, Croatia reference to the obtained findings, it can be said that emo-
* Corresponding author. tional responsiveness is an important protective variable in the
emergence of OCD symptoms and that the emotional regulation
Background and aims.– Conversion disorder is a mental condition skills shape the relationship between these two variables in an
characterized by disruption in voluntary motor or sensor function important way. In this context, it is thought that considering
that can not be explained by neurological nor other general medical these findings in the planning and implementing preventive and
condition. Symptoms usually occur after a stressful life event. Our rehabilitative practices would make the implementations more
aim was to present a wide range of conversive symptoms that can effective.
complicate setting a diagnosis and postpone targeted treatment. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– We will present a series of cases of patients with conver- interest statement.
sion disorder who were hospitalized at the University Psychiatric
E-PP0037 Background and aims.– Improving the pharmacotherapy of epilepsy

Affective disorders in patient with is possible by optimizing pharmacotherapy – creating new dosage
supraventricular arrhythmia forms and ways of administering.
M. Semiglazova1* , I. Abudeeva2 , V. Krasnov3 , F. Paleev4 Methods.– Experiments were performed on 188 white male rats. m-
1 Serbsky Federal Medical Research Center for Psychiatry and ClBHU was administered intragastrically (100 mg/kg). Brain tissue
Narcology, Moscow Research Institute of Psychiatry, Moscow, Russia; samples were taken for assay at the time intervals after adminis-
2 Moscow Regional Research and Clinical Institute, Department of the tration of m-ClBHU: 0–24 hours with a single and long-term use for
vascular surgery with ischemic heart disease, Moscow, Russia; 3 15 days.
Serbsky Federal Medical Research Center for Psychiatry and Results.– The fluctuations in the m-ClBHU concentration revealed
Narcology, Moscow Research Institute of Psychiatry- Affective an observation period: by the 4th hour, a concentration maximum
disorders department, Moscow, Russia; 4 Moscow Regional Research occurred after the administration, after which the concentration
and Clinical Institute, Scientific department, Moscow, Russia gradually decreased, up to 24 h after the administration of m-
* Corresponding author. ClBHU. The anticonvulsant activity of m-ClBHU on the test of
maximum electroshock also changes after a single injection of the
Background and aims.– Anxiety and depression are associated with drug: ED50 is low in the first 4 h, increases in 24 h. The pharmacoki-
adverse cardiac events, including arrhythmia. Co-existance of heart netic parameters of m-ClBHU after a single administration indicate
problems with mood and anxiety disorders creates the vicious cir- a slow release of m-ClBHU brain tissue. Under the conditions of 15-
cle of activation of autonomic nervous system, somatic symptoms day administration of m-ClBHU, its pharmacokinetic profile in the
and unpleased emotions, on which patients focus their attention. brain changes. After reaching a maximum (4 h), there is a sharp drop
Due to this process emotional arousal may influence electro- in the concentration of m-ClBHU in the brain. After 24 h, a marked
stability of the heart. concentration of m-ClBHU is still present in the brain tissue.
To describe the features of mood disorders in patients with Conclusions.– Long-term administration of m-ClBHU to white rats,
supraventricular arrhythmia and to analyse how the complex ther- its elimination from the brain accelerates. however, bioavailability
apy (heart and psychiatric medications) may effect on such group for brain tissue increases. This is due to the activation of neuronal
of sufferers. receptor and transport systems (1). 1. Shushpanova TV1, Solonskii
Methods.– The following methods were used during the 6 months AV, Novozheeva TP, Udut VV. Meta-chlorobenzhydryl urea (m-
of the study: Hamilton depression and anxiety scales, Symptom ClBHU) on the benzodiazepine receptor. Bull Exp Biol Med. 2014,
Checklist-90 (SCL-90), Visual analog scale of arrhythmia (VASa) and 156(6):813-8. doi:10.1007/s10517-014-2458-4.
ECG, Holter monitor tracing. Disclosure of interest.– The authors have not supplied a conflict of
Results.– The study involved 23 patients with supraventricular interest statement.
arrhythmia. The following mental states were revealed: depres-
sive episode in 5 (21,8%), generalized anxiety disorder in 12 (52,2%)
and organic mood disorder in 3 (13,0%) sufferers. VASa showed sig- E-PP0039
nificantly higher scores in patients with severe anxiety (p = 0,002). Mood disorders and quality of life in
Holter monitor tracing found out the correlation between anxiety patients with multiple sclerosis
and supraventricular arrhythmia in most cases (53,6% and 22,2%, A. Kołtuniuk, B. Stańczykiewicz* , J. Rosińczuk
p = 0,017). After 6 month of therapy the group of patients with mood Wroclaw Medical University, Department of Nervous System
disturbances who declined antidepressants have had a poorer out- Diseases- Faculty of Health Sciences-, Wrocław, Poland
come based on Holter and VASa data (p = 0,036). * Corresponding author.
Conclusions.– The presence of affective disorders in patient with
supraventricular arrhythmia is associated with more severe cardi- Background and aims.– Multiple sclerosis (MS) is a chronic, unpre-
ological symptoms. The antidepressant treatment showed efficacy dictable disease responsible for the occurrence of a variety of
for mood symptoms and improve cardiological status. This data can neurological symptoms.
be used to improve the quality of medical care for patients with The aim of the study was to evaluate the impact of mood disorders
supraventricular arrhythmia. on quality of life in patients with multiple sclerosis treated with
Disclosure of interest.– The authors have not supplied a conflict of immunomodulating drugs.
interest statement. Methods.– The study was conducted among 226 MS patients of the
mean age 37.32 ± 9.67. In the study, standardized questionnaires
were used: the Beck Depression Inventory (BDI), the modified Hos-
E-PP0038 pital Anxiety and Depression Scale (HADS–M) and the MusiQol -
Optimizing pharmacotherapy of International questionnaire investigating quality of life in multiple
sclerosis. The results were analyzed statistically.
epilepsy by creating new ways of
Results.– Anxiety was diagnosed in 51 patients (23%), depression
administering of original in 13 patients (6%) and irritability and aggression in 117 patients
anticonvulsant (52%) by HADS - M. The overall score of quality of life measured by
meta-chlorobenzhydryl urea MusiQoL was 55.5 ± 12.1 points on a hundred-point scale. Simple
(m-CLBHU) linear regression analysis model showed the effect of anxiety and
T. Novozheeva1 , E. Markova2 , O. Shushpanova3 , E. Knyazeva4 , T. depression symptoms on the quality of life. These variables have
Shushpanova1* been confirmed in a multiple linear regression model.
1 Mental Health Research Institute of Tomsk National Research Conclusions.– Mood disorders such as anxiety and depression have
Medical Center of RAMSci, Psychoneuroimmunology and a significant negative impact on quality of life in MS patients treated
Neurobiology, Tomsk, Russia; 2 Research Institute of Fundamental with immunomodulating drugs.
and Clinical Immunology, Neuroimmunology, Novosibirsk, Russia; 3 Disclosure of interest.– The authors have not supplied a conflict of
Scientific Center of Mental Health, Study of Children and Adolescent interest statement.
Psychiatry problems, Moscow, Russia; 4 Tomsk Politechnic University,
Basic Engineering school, Tomsk, Russia
E-PP0040 applied Panic and Agoraphobia Scale- clinician rated version (PAS)
Relevance of subdividing anxiety and Inventory for Drug Taking Situations (IDTS) in each patient who
neurosis into generalized anxiety was examined.
Results.– A total number of 63 patients diagnosed with panic disor-
disorder and panic disorder der and agoraphobia were investigated and 46% presented at least
M. Turki* , J. Ben Thabet, M. Maalej, S. Omri, R. Feki, L. Zouari, N.
one substance use disorder. The mean score of PAS in these patients
Charfi, M. Maalej
with dual diagnosis was higher than in patients who had only one
Hedi Chaker University Hospital, Psychiatry “C” Department, Sfax,
diagnosis for dimensions “panic attacks”, “agoraphobic avoidance”,
Tunisia
and “disability” (p < 0.01). The most frequently abused substances
were alcohol (69%), benzodiazepines (55.1%), and opioids (20.7%).
Background and aims.– Despite its official status as a stand-alone A percentage of 65.5 had one substance use disorder, while 20.7%
diagnosis, there continues to be discussion of whether generalized abuse two substances, and 13.8% abused at least three distinct sub-
anxiety disorder (GAD) is truly a separate disorder or instead could stances.
be combined with other anxiety disorders such as panic disorder Conclusions.– Patients with panic disorder and agoraphobia should
(PD). be screened for substance use disorders, because of the high degree
The aim of this study was to investigate factors associated with of overlap between these two pathologies.
GAD-PD comorbidity. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– We conducted a cross-sectional study, among 250 sub- interest statement.
jects consulting in 6 primary care units in Sfax, Tunisia. These
participants, randomly chosen, were asked to answer a ques-
E-PP0042
tionnaire after their consent. The diagnosis of GAD was assessed
through the “Mini International Neuropsychiatric Interview” of Maladaptive interpretation for
the DSM-IV (MINI- DSM-IV). If this diagnosis was retained, then physical symptoms and dysfunctional
comorbid PD was sought by the MINI- DSM-IV. Depressive symp- stress coping in patients with
toms were evaluated using the “Beck Depression Inventory” generalized anxiety disorder
(BDI). J.C. Yang* , Y. Kim
Results.– The GAD was diagnosed in 10.8% (n = 27) of participants. Chonbuk National University Hospital, Psychiatry, Jeonju, Republic of
PD co-occurred in 22.2% (n = 6) of patients with GAD. Accord- Korea
ing to BDI, all patients with GAD-PD comorbidity presented mild, * Corresponding author.
moderate or severe depressive symptoms (16.7%, 66.7% and 16.7%
respectively). No statistically significant associations were found Background and aims.– Generalized anxiety disorder (GAD) patients
between GAD-PD comorbidity and socio-demographic and clinical have various physical symptoms which are affected by sensitivity
parameters. Patients with GAD-PD comorbidity were more likely to for bodily sensation and interpretation pattern for somatic symp-
have histories of suicidal attempts (33.3% vs14.3%), and to present tom. And, they have stressful life events during the illness. The
moderate to severe depressive symptoms (83.3% vs 71.4%), without aim of this study was to investigate the cognitive characteristics of
significant relationships. physical symptom perception and stress coping strategies in GAD
Conclusions.– Showing no sociodemographic or clinical differences patients.
between groups of patients with GAD and those with GAD-PD, our Methods.– 55 GAD patients and 55 normal controls were recruited.
study raised the question of the relevance of subdividing anxiety We evaluated the subjects using Somato-Sensory Amplification
neurosis into PD and GAD. Further studies focusing on therapeutic Scale (SSAS), Symptom Interpretation Questionnaire (SIQ), the Way
aspect can still support this point of view. of Stress Coping Questionnaire (SCQ), and the GAD-7 scales. We
Disclosure of interest.– The authors have not supplied a conflict of analyzed the data using an independent t-test and Pearson’s corre-
interest statement. lation analysis (p < 0.05).
Results.– GAD patients had significantly greater amplification
of bodily sensation in SSAS (41.95 ± 11.29 vs 22.64 ± 7.17,
E-PP0041 p < 0.005), higher score in physical interpretation (37.55 ± 9.47
Substance use disorders comorbidity vs 36.96 ± 8.97, p < 0.05) and psychological interpretation
in a sample of patients with panic (26.85 ± 7.20 vs 25.33 ± 6.19, p < 0.05), and lower score in envi-
ronmental interpretation (21.33 ± 7.51 vs 27.36 ± 6.91, p < 0.05) of
disorder and agoraphobia
SIQ than normal controls. In terms of SCQ, GAD patients presented
D. Vasile* , O. Vasiliu
significantly lower scores on seeking social support (16.13 ± 4.44
University Emergency Central Military Hospital “Dr. Carol Davila”,
vs 18.69 ± 2.65, p < 0.01) and higher scores on wishful thinking
Psychiatry Department, Bucharest, Romania
* Corresponding author. (21.27 ± 4.25 vs 20.56 ± 2.90, p < 0.05) than normal controls. GAD-
7 scores were positively correlated with physical interpretation
Background and aims.– Anxiety disorders and substance use scores on SIQ (p < 0.001).
disorders have a high degree of overlap, and various hypothe- Conclusions.– GAD patients have greater amplification of bodily
ses including shared genetic factors, compensation of anxiety sensation, maladaptive interpretation of somatic symptoms, and
through substance use, or worsening of anxiety by substance use dysfunctional stress coping. These results give a theoretical basis
are investigated. Important consequences of neglecting cases of on necessity for interoceptive exposure to bodily sensation, cogni-
dual diagnosis may appear, both at somatic and psychological tive therapy of maladaptive interpretation, and stress management
level, with functional and quality of life negative impact. The program in the treatments of GAD.
objective was to investigate the occurrence of substance use dis- Disclosure of interest.– The authors have not supplied a conflict of
orders in outpatients patients diagnosed with panic disorder and interest statement.
agoraphobia.
Methods.– All consecutive examined patients in our department
during 6 months, who did not require hospitalization and pre-
sented a diagnosis of panic disorder and agoraphobia, according to
the DSM 5 criteria, were screened for substance use disorder. We
E-PP0043 nephrogenic diabetes insipidus (DI). While PP is primarily char-

Neural correlates of the influence of acterized by increased fluid intake, DI is determined by polyuria
emotion on memory process in due to impaired AVP secretion (central DI) or AVP resistance in the
kidneys (nephrogenic DI). Between 10–20% patients treated with
patients with generalized anxiety lithium develop nephrogenic DI.
disorder The authors present a case report of polydipsia in a patient with
J.C. Yang* , J.I. Park type 1 bipolar disorder treated with lithium.
Chonbuk National University Hospital, Psychiatry, Jeonju, Republic of Methods.– Clinical process consultation and Pubmed search were
Korea performed using the search key words polydipsia, bipolar disorder
and lithium.
Results.– This case report highlights the association between PP
Background and aims.– Despite growing recognition of the impor-
and other psychiatric conditions, as well as the importance of
tance of emotion regulation deficit in generalized anxiety disorder
a correct differential diagnosis for the clinical and therapeutic
(GAD), few studies have assessed neural mechanisms of the effects
approach. The pathogenesis appears to be complex and remains
of emotion on cognition. We evaluated the effects of emotional
largely unknown, but multiple mechanisms like hypersensitivity
and non-emotional distractors on working memory maintenance
to vasopressin, a defect in osmoregulation, stimulation of thirst
in GAD patient using fMRI with face recognition task.
centers by dopamine levels and changes in feedback regulation of
Methods.– 14 GAD patients (mean age = 36.5 ± 11.6 years) and 16
hypothalamic-pituitary axis are proposed.
healthy controls (mean age = 36.1 ± 7.8 years) underwent fMRI
Conclusions.– Psychiatrists should be aware of this clinical condi-
during a face recognition task with non-emotional distractors
tion. More studies should be conducted, aiming for the clarification
(novel face pictures) and emotional distractors (anxiety-provoking
of the etiopathogenesis of this phenomenon.
pictures). The paradigm consisted of trials with the sequence
“encoding - maintenance - distractor - retrieval”. In the retrieval
interest statement.
task, participants were presented either the previously encoded
face or a new face, asked whether they recognize the face. Brain
activation maps were compared between groups and between each E-PP0045
distractor condition.
Results.– For non-emotional distractors, the groups showed no sig-
Effect of nutraceuticals added to
nificant differences in face recognition task accuracy, and both standard care in bipolar disorder: a
groups showed significant activation of ventromedial prefrontal systematic review of randomized
cortex (VMPFC), ventrolateral prefrontal cortex, dorsolateral pre- controlled trials
frontal cortex (DLPFC), superior and inferior parietal gyrus, anterior L. Fusar-Poli* , A. Vanella, T. Surace, V. Meo, F. Patania, R. Furnari, E.
cingulated gyrus, fusiform gyrus (all p < 0.005). For emotional Aguglia
distractors, accuracy was lower in GAD patients than healthy con- University of Catania, Department of Clinical and Experimental
trols (61.1 ± 16.5% and 64.7 ± 9.9%, respectively, p < 0.05), and GAD Medicine- Psychiatry Unit, Catania, Italy
patients showed significantly increased activation in brain areas of * Corresponding author.
VMPFC, DLPFC, parahippocampal gyrus, and amygdala, compared
with healthy controls (p < 0.005). Background and aims.– Several studies have evaluated the poten-
Conclusions.– Working memory maintenance of GAD patients was tial role of nutrients deficits in the etiology of psychiatric diseases,
significantly impaired by emotional distractors. Particular activa- such as depression or anxiety. In some conditions, nutraceuticals
tion of parahippocampal gyrus and amygdale may be related with (e.g. omega-3 fatty acids, vitamins, minerals, amino acids, probi-
this impairment. otics) seemed to potentiate the effect of standard pharmacological
Disclosure of interest.– The authors have not supplied a conflict of therapy. The present systematic review was aimed at evaluating
interest statement. the efficacy and safety of nutraceuticals in patients with bipolar
disorder.
Methods.– In August 2018, we searched the following databases:
Web of Science, Cinahl, Embase, and PsycINFO, with no time restric-
E-Poster Presentation: Bipolar Disorders - Part II / tions, and we hand-searched the references of all retrieved reviews.
Substance related and Addictive disorders - Part II After removing duplicates and excluding irrelevant publications,
we selected all randomized controlled trials (RCT) which evaluated
the efficacy of nutraceuticals in addition to standard care in patients
E-PP0044 with bipolar disorder, compared to standard care alone or placebo
Excessive water ingestion - why plus standard care.
Results.– Literature search yielded 6146 references. We finally
should psychiatrists be alert included 27 RCT, testing omega-3 fatty acids and similar (12 arti-
F. Freitas1* , J. Pereira1 , M. Bairrão1 , J.M. Oliveira1 , V. Viveiros1 , J.M.
cles), amino acids and derived (9), vitamins and minerals (9) and
Jara2
1 Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisboa, probiotics (1). The majority of studies showed significant effects
of omega-3, amino acids and micronutrients on core symptoms of
Portugal; 2 Centro Hospitalar Lisboa Central, Psychiatry, Lisboa,
bipolar disorders, such as depression or mania. No significant differ-
Portugal
* Corresponding author. ences between probiotics and placebo were found. Nutraceuticals
appeared also safe.
Background and aims.– Psychogenic polydipsia (PP) which is char- Conclusions.– In conclusion, the use of nutraceuticals in the
acterized by excessive water drinking without physiologic stimuli treatment of bipolar disorder might be useful in add-on to psy-
has been reported in 6–20% of psychiatry patients with the diagno- chopharmacological therapy. Given the growing interests of both
sis of schizophrenia, bipolar disorder, mental retardation, alcohol scientific community and psychiatric patients towards the use of
dependence, eating disorders and organic mental disorder. The complementary and alternative therapies, the implementation of
illness develops in three phases, beginning with polydipsia and further RCT to evaluate the efficacy of nutraceuticals should be
polyuria, followed by hyponatremia and finally water intoxication, promoted.
which may be fatal. The differential diagnoses of PP are central and
Disclosure of interest.– The authors have not supplied a conflict of Objective.– to investigate differences between men and women in
interest statement. clinical characteristics, cognition, functioning, and QoL among BD
patients, according to their history of cannabis use.
Methods.– Secondary analysis of a cross-sectional, naturalistic, mul-
E-PP0046 ticenter study. 224 Spanish BD outpatients. Lifetime Cannabis Use
Lipids, cholesterol and suicide risk in (LCU):any use of cannabis during at least 6 months throughout
a Romanian bipolar population patient life. Assessment: demographic and clinical information;
V.P. Matei, A.C. Galatanu* , A.E. Rosca, A.N. Pavel, A. Giurgiuca psychopathology: HDRS, YMRS, HARS, CSFQ, CGI; cognition: SCIP;
“Prof. Dr. Alexandru Obregia” Psychiatric Hospital, Psychiatry, functioning: FAST, EEAG; QoL: SF-36. Statistical analysis: Chi
Bucharest, Romania square, t-student, and hierarchical multiple regression.
* Corresponding author. Results.– Mean age 47.28; 65.3% females; 71.3%; Bipolar-I. Sta-
tistical significant differences (p < 0.05) between LCU and never
Background and aims.– Suicide is one of the most important cause cannabis use were found for age in men, and for age, marital
of death in subjects with bipolar disorder (BD) (1). A meta-analysis status, sexual functioning, financial functioning, and QoL (bodily
suggests that suicidal pacients had significantly lower total choles- pain, vitality, social functioning, emotional role, mental health,
terol, low-density lipoprotein cholesterol (LDL-C) and triglycerides and mental summary component) in women. After controlling by
serum levels compared with nonsuicidal (2) while another study confounders, significant models were obtained for emotional role
focused on suicidal bipolar pacients found no differences (3). Our (R2 = 0.052), and mental health (R2 = 0.081) dimensions in women.
study’s aim is to determine whether plasma lipid levels are associ- In both models, the variables retained were cannabis use, and finan-
ated with a history of serious suicide attempts in bipolar patients. cial functioning.
Methods.– This study included 75 patients between 18 and 65 Conclusions.– A lifetime history of cannabis use and financial func-
years old with a documented diagnosis of bipolar I disorder. The tioning were associated with worse self-reported emotional role
Romanian version of the Columbia Suicide Severity Rating Scale and mental health quality of life among women with bipolar dis-
was used for assessing suicidal ideation and behaviour. The sta- order.
tistical analysis was performed using IBM SPSS 20. Continuous Disclosure of interest.– The authors have not supplied a conflict of
normally distributed data was analysed with t-test. Continuous interest statement.
non-normally distributed data was analysed with Mann-Whitney
test. Statistically significant alpha value was set at .05.
Results.– The number of patients with lifetime suicide attempts E-PP0048
in our cohort was 24 (34.3%) and 11 (15.7%) needed medical High levels of cortisol and BDNF
hospitalization, representing the “severe suicide attempts” group. associated with bipolar disorder
The 46 (65.7%) bipolar patients that never had a suicide attempt A. Gupta1* , M. Andrabi1 , V. Subbiah2 , A. Hussain3
were compared with the severe suicide attempters. LDL-C was 1 All India Institute of Medical Sciences, Neurobiochemistry, New
statisticaly significant increased in the “severe suicide attempt” Delhi, India; 2 All India Institute of Medical Sciences, Biochemistry,
group compared to non-suicidal patients (148.2 mg/dl compared Rishikesh, India; 3 Government Medical College, Psychiatry, Srinagar,
to 121.6 mg/dl, p = 0.031, U = 1249, Z = −1.719). India
Conclusions.– Our study showed a positive association between * Corresponding author.
LDL-cholesterol and severe suicide attempts in bipolar patients.
More research is needed to clarify the link between lipid Background and aims.– Bipolar disorder (BD) is a highly disabling
metabolism and suicide risk and to discover putative biomarkers chronic mood disorder characterized by the presence of manic
for suicide in bipolar disorder. and depressive symptoms and a lifetime prevalence of 3.9%. Over
Disclosure of interest.– The authors have not supplied a conflict of the years, researchers have pointed to a potential link between
interest statement. hypersecretion of cortisol, vitamin D deficiency, deranged BDNF
and neuropsychiatric illness, including major depressive disorder
(MDD) and Bipolar Disorder (BD). Circadian disruption stands out
E-PP0047 as potential contributor to the etiology of BD but, only a few such
Gender differences in bipolar studies have assessed patients with and without seasonality.
disorder: a history of cannabis use is We sought out to find levels of cortisol, vitamin D and BDNF in BD
with (BDS) or with out seasonality (BD).
associated with worse quality of life in
Methods.– A total of 90 subjects were taken in this study, BD
women (30), BDS (30) and controls (30). BDNF levels were estimated by
L. de la Fuente-Tomás1 , Á. Velasco1 , L. García-Álvarez1 , L. sandwich ELISA. Cortisol and Vit D levels were estimated using
González - Blanco1 , C. Moya2 , F. Dal Santo2 , P. Sáiz1 , J. Bobes1 , M.P. chemiluminescence. One way ANOVA was carried between SDCON,
Garcia-Portilla1* SDT and LiT groups using Graph Pad Prism 5. Post hoc analysis was
1 University of Oviedo- CIBERSAM, Psychiatry, Oviedo, Spain; 2
carried by Tukey Test. In all experiments, P values less than 0.05
University of Oviedo- SESPA, Psyquiatry, Oviedo, Spain were considered to indicate statistical significance
Results.– We observed significant difference in cortisol and BDNF
Background and aims.– Cannabis use is widely extended in the levels between patients and controls. The difference was insignif-
worldwide. Epidemiologic studies have shown a high prevalence icant between BD and BDS. There was no significant difference of
of cannabis use among patients with bipolar disorder (BD), find- Vit D levels between cases and controls.
ing rates among 36% to 46%. Cannabis use seems to be related Conclusions.– Results implicate deranged circadian system and neu-
with a worse course and a poorer Quality of Life (QoL) in BD roplasticity in Bipolar Disorder.
patients. Despite evidence of some differences among cannabis Disclosure of interest.– The authors have not supplied a conflict of
users between men and women in general population and depres- interest statement.
sive patients, no studies have been found in BD patients.
E-PP0049 Methods.– Ethnological, clinical-epidemiological and statistical

Symptoms and clinical course of methods of research were used. Data of the statistical reporting
inpatients with unipolar versus across the area in populations of indigenous ethnic groups (Khanty
and Mansi) in comparison with other population of the area were
bipolar depression used.
K. Hebbrecht1,2* , M. Stuivenga1,2 , T. Birkenhäger3 , R. Vandermast4 ,
Results.– The comparative analysis of incidence of alcoholism across
E. Giltay1,4 , B. Sabbe1,2
1 Collaborative Antwerp Psychiatric Research Institute CAPRI, Faculty
Khanty-Mansi Autonomous Area, along with similar data on the
Ural Federal District (UFD) and the Russian Federation (RF) for 10-
of Medicine and Health Sciences- University of Antwerp, Antwerpen,
year period confirms decrease in indicators for newly registered
Belgium; 2 Psychiatric Hospital Duffel, University Department, Duffel,
patients across all territories almost twice. Decrease in indicators
Belgium; 3 Erasmus University Medical Center, Psychiatric
of UFD and the Russian Federation is linear, at lower rates in UFD.
Department, Rotterdam, The Netherlands; 4 Leiden University
Median indicators of incidence of alcoholism across administrative
Medical Center, Department of Psychiatry, Leiden, The Netherlands
units of Yugra vary from 34.7 to 502.3 per 100,000 of the corre-
sponding population.
Background and aims.– Many studies investigated differences in Conclusions.– High rates of primary incidence of alcoholism for the
symptom profile and outcome between major depressive disorder population of KhMAO, their wide range across administrative units
(MDD) and bipolar depression (BD). However, studies with short- of the area, the spasmodic nature of changes of this indicator allow
interval assessments in real-life inpatients settings are scarce. Our to assume about an essential contribution to the narcological situ-
aim was to study the differences in baseline symptom profile and ation of the region of high rates of prevalence of alcoholism among
time to reach response and remission during hospitalization in a indigenous small peoples of the North.
naturalistic sample of depressed inpatients (MDD versus BD). Disclosure of interest.– The authors have not supplied a conflict of
Methods.– A cohort of 276 inpatients with DSM-IV MDD (n = 224) interest statement.
or BD (n = 52) was followed during their hospitalization period
using routine outcome measurements (ROM) which included a
E-PP0051
structured diagnostic interview at baseline (Mini-International
Neuropsychiatric Interview; MINI plus) and repeated Hamilton Alcoholism: correlations between the
Depression Rating Scale-17) every two weeks. MDD and BD were duration of chronic alcohol use and
compared regarding their symptom profiles and time to response theory of mind
and remission of the depressive episode during the time of hospi- C. Bredicean1* , C. Giurgi-Oncu1 , I. Rivis2 , I. Papava1 , Z. Popovici3 ,
talization. Furthermore, the concordance between MINI-Plus and M. Frandes4
clinical diagnoses was analyzed. 1 UMFT, Neurosciences, Timisoara, Romania; 2 SCJUT nr.1, Psychiatry,
Results.– Patients were on average 49,4 years old and 64,6% were Timisoara, Romania; 3 CSM, Psychiatry, Arad, Romania; 4 UMFT,
female. Those with MDD and BD did not differ significantly in Biostatistics and Medical Informatics, Timisoara, Romania
sociodemographic characteristics. MDD versus bipolar depression * Corresponding author.
increases the chance of response during the first month, but bipo-
lar depression confers long-term benefit on the chance of symptom Background and aims.– Theory of mind (ToM) represents the ability
response. We found an overall acceptable agreement (median effi- to deduce others’ mental states, such as their thoughts, intentions,
ciency of 89.,5, median AUC of 0.83) between MINI and clinical desires and beliefs. Chronic alcohol use leads to various cerebral
diagnosis of BD. alterations, including in the areas that are involved in emotion
Conclusions.– Unipolar depressed patients showed an initial (<4 identification.
weeks) faster rate of response, but subsequently bipolar depressed Aims.– We intended to highlight potential correlations between
patients showed a stronger rate of response. Remission rates were the duration of alcohol use and the degree of ToM impairment in
also stronger in BD than in MDD. individuals with chronic alcohol difficulties.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– We included a total of 51 subjects, who were admitted
interest statement. to the Psychiatric Clinic of Timisoara, with a diagnosis of chronic
alcoholism (F10 according to the WHO ICD 10), in 2017. These indi-
viduals were grouped based on their risk of alcohol dependence.
E-PP0050 We collected various parameters, such as: socio-demographic data,
Epidemiology of alcohol addiction in clinical data (AUDIT) and ToM (“Reading the Mind in the Eyes” test)
data.
khanty-mansi autonomous area
Results.– We found that the ability to recognize emotions was
N. Bokhan1* , A. Novikov2 , L. Rakhmazova1 , O. Gilburd3
1 directly correlated with the duration of alcohol consumption in
Mental Health Research Institute- Tomsk National Research
patients that presented a low risk of alcohol dependence (Spear-
Medical Center- Russian Academy of Sciences, Addictive States
man’s r = 0.401, p = 0.667). On the contrary, we observed that
Department, Tomsk, Russia; 2 KhMAO - Yugra “The Surgut Clinical
emotion identification abilities were inversely correlated with the
Psychoneurological Clinic”, Administration, Yugra, Russia; 3 Surgut
duration of alcohol consumption in subjects at a medium and high
State University, Department of Psychiatry, Surgut, Russia
* Corresponding author. risk of alcohol dependence (Spearman’s r = −0.205, p = 0.741).
Conclusions.– Our results showed that the duration of alcohol con-
Background and aims.– The disadapting influence of industri- sumption appears be directly associated with a reduction in the
alization of Western Siberia, including KhMAO, promotes a ability of identifying emotions in the eyes of others, suggesting
malignization of alcohol-related behavior of the indigenous ethnic clear Theory of Mind deficits in subjects with chronic alcohol use
groups of the North (IEGN) that is reflected in the alcoholic situation difficulties.
in this region: level of primary incidence of alcoholism in KhMAO Disclosure of interest.– The authors have not supplied a conflict of
is 25% higher, than on average in the Russian Federation. interest statement.
Objective.– Study of prevalence of alcoholism and identification of
ethnocultural specifics of incidence of alcoholism in population of
aboriginals of Khanty-Mansi Autonomous Area (KhMAO).
E-PP0052 ␣ was .63 that is acceptable for research purposes. The scale was
Assessment of possibilities for raising not reliable in controls indicating that there is a specific clinical
the quality of health care provided to phenomenon. Tendency for extreme opinion is higher in adoles-
cents involved in drug use (F = 13.25, p < .01, 2 = .04) and related to
opioid users by increasing access to self-regulatory difficulties – unwillingness to make plans for future
substitution treatment and consider alternatives (r = −.21, p < .05).
B. Bukowska Conclusions.– Results support the tendency for extreme opinion in
Ministry of Health, National Bureau for Drug Prevention, Warsaw, adolescents using drugs comparing to controls. Further research
Poland could clarify what kind of content provoke extreme replies in clin-
Background and aims.– In Poland substitution treatment covers only ical sample. Research is supported by the Russian Foundation for
between 13% and 25% people addicted to opioids, especially heroin. Basic Research, project No. 17-06-00271.
The participation of general practitioners in implementing sub- Disclosure of interest.– The authors have not supplied a conflict of
stitution treatment fosters good availability of the treatment. In interest statement.
Poland general practitioners do not participate in the substitution
treatment
Aims.– (1) learning about the features of general practitioners (their E-PP0054
attitudes, beliefs, level of knowledge) as regards opioid users and An analysis of alcohol due hospital
substitution treatment, (2) perception of barriers as regards substi-
admissions in december 2017
tution treatment by general practitioners.
A. Ciubara1* , M. Terpan2
Methods.– Individual in-depth interviews with 27 general prac- 1 Faculty of Medicine and Pharmacy- University “Dunarea de
titioners were conducted. The research employed purposive
Jos”-“Elisabeta Doamna” Hospital, Psychiatry, Galati, Romania; 2
sampling. ATLAS.ti (version 5.5.3) software was used for analysis.
Faculty of Medicine and Pharmacy- University “Dunarea de Jos”,
Results.– General practitioners in Poland have low self-evaluation
Psychiatry, Galati, Romania
of their competence concerning substitution treatment, ambiguous * Corresponding author.
attitudes and opinions concerning drug users and drug addiction.
Structural barriers include too high a number of patients that an Background and aims.– Annually, there is a dynamic related to the
individual primary care physician has to provide service. number of admissions and resources allocated to these disorders.
Conclusions.– Insufficient knowledge, negative attitudes towards It is believed that alcohol consumption increases in free weekdays
this patient group and having too many patients registered on the and holidays.
practice list may be the key obstacles to implementing substitution In this paper we will investigate whether there is a correlation
treatment by general practitioners. What may contribute to the between the number of admissions due to alcohol related disorders
commitment of physicians to substitution treatment is the belief and the end of the week and the winter holidays, in December.
that substitution treatment falls within the scope of their respon- Methods.– The ICD-10 criteria were applied to patients admitted in
sibilities, recognizing health benefits that substitution treatment December 2017 to the Psychiatric Hospital. The study performed
brings to a patient and that implementing the treatment within was a retrospective analysis with 257 participants.
the scope of primary health care unit reduces the stigmatisation of Results.– In the last week of the month that corresponds to the end
this patient group. of the year there is an increase in intoxication from an average of
Disclosure of interest.– The authors have not supplied a conflict of 33 admissions / week (24.48%) to 66 (40%), while the withdrawals
interest statement. remain at the same level, 19 admissions / week (22–30%). Although
the number of week-end intoxication accounts for an average of
30% (maximum 35.30% in the first week - 27.30% minimum in the
E-PP0053 last week), there is no increased positive correlation with the end of
Tendency for extreme opinions in the month celebrations. Concerning the withdrawal due weekend
adolescents involved in drug use: admissions, the average is between (26.66% - 23.80%) with the low-
developing of diagnostic scale est in the last week (16.66%). The smallest number of admissions is
E. Rasskazova1 , A. Tkhostov2 , E. Demenko3 , E. Bryun3 , V. recorded on Tuesdays and Wednesdays.
Arshinova3 , R. Vlasovskikh3 , A. Novakov3 , A. Chepeliuk4* Conclusions.– Although there is a significant increase in the number
1 Moscow State University- Mental Health Research Center, Clinical of admissions due to acute intoxication in the last week, there is no
Psychology, Moscow, Russia; 2 Moscow- State University- I.M. direct correlation between end-of-week days and an increase in the
Sechenov First Moscow State Medical University, Clinical Psychology, number of total admissions.
Moscow, Russia; 3 Moscow Research and Practical Center of Disclosure of interest.– The authors have not supplied a conflict of
Narcology, Addiction Medicine, Moscow, Russia; 4 Moscow State interest statement.
University, Clinical Psychology, Moscow, Russia
E-PP0055
Background and aims.– “Black-and-white” thinking and “jumping Abuse of ethyl chloride in sexual
to conclusions” are considered as a cognitive strategies related to context. Un uncommon drug
a wide range of mental pathology including additions. Impulsiv-
associated with chemsex? a case
ity and self-regulatory difficulties found in adolescents with drug
dependence (Shim et al., 2013, Verdejo-Garcia et al., 2007) sup- report and review
port this hypothesis. The aim was to reveal items with bimodal J. Curto Ramos* , I.I. Louzao Rojas, J.M. Pastor Haro, M.D. Trigo
distribution of frequencies in drug users comparing to controls and Varela, I. López Álvarez, V. Romero Pardo, C. Casado San Martín, B.
construct a Tendency for Extreme Opinions Scale. Rodríguez Vega, M.F. Bravo Ortiz
Methods.– 637 pupils of the upper grades of general education University Hospital La Paz, Psychiatry and Mental Health
schools from 12 subjects of the Russian Federation and 108 patients Department, Madrid, Spain
of the Narcology Center 12–19 years old filled Inventory of Psycho-
logical Risk Factors For Drug Use in Adolescents. Background and aims.– Ethyl chloride is an aerosol spray used for
Results.– We revealed 7 items (with various content) having local anesthesia, that can be used as an inhalant of abuse. It has
bimodal distribution only in the clinical group (p < .05). Cronbach’s
a depressant effect on central nervous system, and act as well E-PP0057

enhancing sexual pleasure. The intentional use of drugs before or Management of Zolpidem
during sexual intercourse (chemsex) is a phenomenon of special
withdrawal- the review of published
importance in the MSM (men who have sex with men) population
due to its impact on health.
treatment regimens
Methods.– We report the case of a patient with multiple drugs W. Dróżdż1 , M. Skibicka2 , L. Giziński3 , B. Kowalewska3
1 IInd Clinic of Psychiatry, Psychiatry, Torun, Poland; 2 II nd
abuse, including ethyl chloride abuse, in order to review the evi-
dence about the mechansims of action of this drug, its efects on Psychiatric Ward, Bieganski Regional Hospital, Grudziadz, Poland; 3 II
sexual pleasure, toxicity, patterns of abuse and health related con- nd Clinic of Psychiatry, Psychiatry, Bydgoszcz, Poland
sequences it may present.
Results.– To our knowledge, this is the first case published of a Background and aims.– Zolpidem is one of the most frequently pre-
patient using ethyl chloride as a substance in chemsex practice. As scribed medications for insomnia. Many patients continue to take it
the patient presented in our emergency with ataxia, dysarthria and for a long time and in doses higher than recommended. Zolpidem
tremor, he was diagnosed with “encephalopathy by ethyl chloride” abuse often leads to dependence as it loses its selectivity for the
and was admitted to the internal medicine ward. Neurologic toxic- GABA-␣1 subunit in higher doses and when used chronically. Clin-
ity, mental health problems and even deaths have been previously ical symptoms associated with Zolpidem misuse, observed in some
reported in acute and chronic abuse of this substance. patients, include euphoria, emotional lability or psychotic symp-
Conclusions.– Inhalant abuse is common and it can be difficult to toms, agitation and disorientation. These effects can be attributed
detect. Due to its action enhancing sexual pleasure and its high not only to the influence of the drug on GABA -A subunits, but
availability, use and abuse of ethyl chloride should be considered also to the modulation of other receptor pathways, particularly
when treating patients with chemsex practices, especially when dopaminergic pathways.
presenting with neurological symptoms. Methods.– Data on Zolpidem withdrawal therapy is based primarily
Disclosure of interest.– The authors have not supplied a conflict of on individual case reports and case series.
interest statement. Results.– Substitution with Diazepam, Clorazepate or Clonazepam
has been a core feature of the treatments in the published
reports. However, therapy with an antiepileptic medication (Val-
E-PP0056
proate, Pregabaline or Gabapentine) is described in some instances.
Treatment of GHB/GBL withdrawal Flumazenil was also used, either as monotherapy or in conjunction
delirium: a case report with Valproate.
M. Delic Conclusions.– Thus far these programmes have had moderate short
University Psychiatric Hospital Ljubljana, Center for Treatment of success rates. Conversely, in the long-term many patients returned
Drug Addiction, Ljubljana, Slovenia to Zolpidem use.
Background and aims.– Gamma-hydroxybutyrate (GHB) and its pre- Disclosure of interest.– The authors have not supplied a conflict of
cursor gamma-butyrolactone (GBL) are popular drugs of abuse interest statement.
used for their euphoric, (potential) anabolic, sedative, and amnes-
tic properties. Daily use of GHB/GBL can lead to addiction and
the possibility of withdrawal syndrome on cessation which results
in tremor, tachycardia, insomnia, anxiety, hypertension, delirium, E-Poster Presentation: Bipolar Disorders - Part III
coma. It is also recommended that all addicted users of GHB/GBL are
advised not to stop use abruptly or to attempt self-detoxification.
Medical assistance should be sought. E-PP0058
Methods.– We will present inpatient medically assisted detoxifica- Evaluation of school educators’
tion of 30 years old patient addicted to GHB/GBL.
knowledge on hygiene and trauma
Results.– He reported use of 30 ml of GBL and 0.5 to 1 g of cocaine
daily. Withdrawal symptoms appeared 2 hours after the last dose prevention of students with autism
of GBL, and consisted of diaphoresis, tremors, tachycardia, hyper- spectrum disorder (ASD) in Greece
tension and later delirium with disorientation to time, place and K. Drosopanagioti1 , X. Sinopidis2 , K. Argyropoulos3 , D.
person, poor attention and agitation. Symptoms were success- Avramidis4* , A. Karatza5 , E. Jelastopulu3
1 Special school for children with ASD, Postgraduate Student, Patras,
fully managed with clomethiazole, propranolol and risperidone.
We observed resistance to benzodiazepines and quetiapine what Greece; 2 School of Medicine- University of Patras, Pediatric Surgery,
was the first-line treatment. After 3 days symptoms of delirium Patras, Greece; 3 School of Medicine- University of Patras, Public
disappeared. Health, Patras, Greece; 4 University of Patras- Greece, School of
Conclusions.– After sudden cessation or reduction of intensive Medicine, Patras, Greece; 5 School of Medicine- University of Patras,
GHB/GBL use, a severe withdrawal syndrome may occur with Pediatrics, Patras, Greece
symptoms varying from tremor, anxiety and agitation to autonomic
instability, hallucinations and delirium. In described case, first-line
treatment with benzodiazepines was less effective, necessitating Background and aims.– Students with autism spectrum disorder
the use of other sedative agent with supportive care and additional (ASD) in Greece follow educational programs both in regular and
symptomatic therapy. special schools either for ASD alone or together with children with
Disclosure of interest.– The authors have not supplied a conflict of different psychical morbidities. ASD students demonstrate hygiene
interest statement. and trauma particularities, while related variations are found in the
educational system and the community.
The aim of the present study was to evaluate the school educa-
tors’ knowledge on hygiene and trauma prevention in students
with ASD. To estimate the associated influence of factors such as
specialty, training, experience, school type and location, student
population.
Methods.– A digital questionnaire of 31 questions was distributed
to educators throughout the country. The questions regarded
demographics, work position details, experience with ASD stu- E-PP0060

dents, educational skills on hygiene and trauma prevention of these Autism specter disorder in Albania:
students, their attitude on educational and community infras-
first concerns and late diagnosis
tructure adequacy, and their beliefs on the solutions that would
Z. Besmira1* , V. Kodra2 , D. Sanxhaku2 , V. Alikaj2
augment their sufficiency. Statistical analysis was performed, to 1 University Hospital Center “Mother Teresa” Tirana, Child and
identify the major factors that affected their level of knowledge.
Adolescent Psychiatry, Tirana, Albania; 2 University Hospital “Mother
Results.– A cohort of 547 educators participated to the survey.
Teresa” Tirana, Child and Adolescent Psychiatry, Tirana, Albania
The majority of respondents worked in urban (74%) elementary * Corresponding author.
(76%) regular (94%) schools, and had already some experience with
ASD students (61%). Discrepancy was found among them on edu- Background and aims.– Introduction: The diagnosis of autism is
cation and prevention knowledge, especially in earthquake and often delayed, which translates into a missed opportunity to
fire management. School-type, specialty and training affected their provide treatment during a critical developmental period [1]. Indi-
knowledge (P < 0.05), in contrast to school location or ASD students viduals from lower- and middle-income countries have fewer
presence. mental health services than those from high-income countries. Also
Conclusions.– Educators often deal with ASD students. They do not the gap between the first concerns and diagnosis is less than 2 years
feel confident of their skills or the infrastructure that protects these for nearly half of children with autism [2]. In a study conducted
students. They express the need of training programs. prevalence of autism in Albania, was estimated at 1.31% [3].
Disclosure of interest.– The authors have not supplied a conflict of Objective.– This study aims to provide data according the first
interest statement. concerns of autism spectrum disorder, from whom are they first
detected and the time of diagnosis in Albania.
Methods.– We analyzed the data collected by a constructed inter-
E-PP0059 view of 29 children, aged 7–19 years with diagnosis of Autism
Psychopathology in children of Spectrum Disorder. The interview was conducted in Child and Ado-
mothers with borderline personality lescent Psychiatric Hospital in Albania during March–May 2018.
disorder The sample consisted of children 7 female and 22 male.
A.M. Bernardo1* , S. Nascimento2 Results.– In 83% of the cases first concerns were detected from
1 Hospital Garcia de Orta, Serviço de Psiquiatria e Saúde Mental, parents and in 10% from the pediatrician. Age of diagnosis was
Almada, Portugal; 2 Centro Hospitalar Universitário do Algarve, mainly 1–3 years after the detection of first concerns while the gap
Serviço de Psiquiatria e Saúde Mental, Faro, Portugal between the first concerns and diagnosis was more than 2 years in
* Corresponding author. 69% of the children.
Conclusions.– It is noticed that the age of diagnosis remains still
Background and aims.– Children of mothers with borderline per- high causing poor outcome for this children. The improvement of
sonality disorder (BPD) are at greater risk to develop child behavior the health system with increasing number of child and adolescent
problems and psychopathology, including BPD in the future. Moth- psychiatrist and better mental health politics would make possible
ers with BPD tend to show increased hostility during mother-child an earlier diagnosis and intervention of children with autism.
interaction and may have difficulties with bonding, affect attune- Disclosure of interest.– The authors have not supplied a conflict of
ment and attachment. Their limited ability to negotiate a secure interest statement.
attachment with their babies, associated with reduced maternal
emotional availability might play a critical role in transmitting
maternal psychopathology on the child. The purpose of this work is E-PP0061
to describe the state of art of medical literature about psychopathol- The paper presents a
ogy in infants of mothers with borderline personality disorder. psychopathological analysis of the
Methods.– The authors revised the published literature about this
health status of pupils of an
topic, selecting the relevant articles with the topic words: “bor-
derline personality disorder”, “motherhood/mother” and “children orphanage in chita, trans-baikal
psychopatology” in scientific date base. territory. The main psycho-emotional
Results.– The studies included children within all ages (since disorders: anxiety, depressive state
newborns until adolescence) and all revealed congruent and E. Bodagova
complementary findings in the presence of psychopatology in Ekaterina Bodagova, Chita State Medical Academy, Chita, Russia
the children of BPD mothers. Infants of BPD mothers express Background and aims.–
less positive vocalizations and less nonautonomic self-regulation Purpose.– A clinical and psychopathological analysis of the health
than infants of mothers with no psychopathology. There was status of the pupils of the Center for helping children left without
also an association of maladaptive mother-child interactions parental care.
and BPD symptoms, such as impulsivity, dissociation and affec- Methods.– Psychometric examination: the Bass-Darki question-
tive/behavioral dysregulation. naire, Spielberger-Khanin questionnaire, M. Kovacs questionnaire,
Conclusions.– There is a need for the creation of training programs Leonhard-Shmishek questionnaire and the suicidal risk question-
for BPD mothers and their children that cover all stages of devel- naire (modified by TN Razuvaeva).
opment, from early life to adulthood. Results.– Children from 3–10 years old made up 14.0% (n = 8), from
Disclosure of interest.– The authors have not supplied a conflict of 11–17 years old - 86.0% (n = 49). Clinical and psychopathological
interest statement. analysis confirms the dysfunctional psycho-emotional state of the
pupils of the Center. Thus, situational anxiety of moderate level
was detected 59.2%; a high level - 16.3%. Personal anxiety of mod-
erate level - 61.2%; a high level - 24.5%. The majority had an easy
level of depression- 34.7%; subdepressive state - 6.1% and severe
depression was detected only 2%. Suicidal risk is expressed and
detected in 65.3%; not expressed - in 34.7%. Anti-suicidal factor is
absent in 22.4% of children. The high and medium level of aggres-
siveness was determined in 10.2% due to such indicators as “verbal
aggression”, “physical aggression” and “irritability”. The hostility
among the pupils was revealed mainly only on the average level - in Such pigmentation of the hair affects patients with blond hair that
36.7%. It was revealed that 49% of children are accentuated person- have been exposed to water containing an excess amount of copper
alities, mostly they have epileptoid, demonstrative, hyperthymic, ions. Increased content of copper in the water is a premise for dam-
and mixed types of character accentuation. At the same time, the aged hair to turn green. Hair can be damaged mechanically, from
tendencies to different types were detected in 47% and only 4% did the sun, by coloring it, by curling it, by straightening it, often use of
not accentuate the character. chlorine water on it or use of alkaline shampoos.
Conclusions.– The main psycho-emotional disorders in orphans are Results.– After this stressful event the younger sister changed her
identified: anxiety, depression, high suicidal risk. behavior – crying all the time, wants to cut shortly her hair, has
Disclosure of interest.– The authors have not supplied a conflict of nightmares, no appetite. This was the reason for parents to search a
interest statement. psychiatric help. The child and the parents visited a psychotherapist
for a month and now she almost forgot the green hair.
Conclusions.– Any change in appearance in children, although for
E-PP0062 adults to look insignificant, can lead to problems in the mental
It’s complicated – technology, mental development of children.
health and family dynamics – changes Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
and impact on clinical practise. Is
there a paradigm shift? clinical
psychologist’s personal view E-PP0064
P. Budzyna-Dawidowski Interpersonal reactivity index
Waitemata District Health Board, Marinoto West, Auckland, New adolescents version: factor structure
Zealand
Background and aims.– In the presentation the author reviews the
and psychometric properties
literature and personal clinical experience in day to day practise and M. Cunha1* , L. Coutinho2 , I. Massano-Cardoso3 , A. Galhardo1
1 Miguel Torga Institute/CINEICC- FPCE University of Coimbra,
changes in symptomatology, diagnosis and treatment of children
and adolescents in an outpatient setting. Clinical Psychology, Coimbra, Portugal; 2 ISMT, Clinical Psychology,
Methods.– In light of well recognised psychological phenomena Coimbra, Portugal; 3 Instituto Superior Miguel Torga and Faculty of
associated with or affected by emerging technology, the author Medicine of the University of Coimbra and Faculty of Economics of
summarises clinical experience in relation to the mutual inter- the University of Coimbra, Ceisuc, Coimbra, Portugal
action between the human mind and behaviour, and digital
technology. Background and aims.– Empathy can be defined as one’s ability to
Results.– Explored are the effects of virtual reality, online iden- understand and share the feelings of another. It is a multi-faceted
tity, online relationships, personality types in cyberspace, gaming construct and the Interpersonal Reactivity Index (IRI) is a widely
addiction, aggression in cyberspace online gender switching used tool for its assessment. An IRI Portuguese version for adults is
and negative effects of digital technology such as low self- already available revealing good psychometric properties.
esteem, depression, low life satisfaction, depression social isolation, Objectives.– Adapt the IRI for adolescents and explore its factor
ostracism, bullying and sleep deprivation. structure and psychometric characteristics. Study the association
Conclusions.– The author concludes that while there are many pos- between the IRI and other types of positive affect and psychopatho-
itive sides to digital technology and positive effects on human logical symptomatology.
functioning, there are major psychopathological effects stemming Methods.– A sample of 201 adolescents, 82 boys and 119 girls, with
from its inappropriate use. The changes require a different clinical ages between 11 and 18 years old, attending the 7th to 12th years
approach and may instigate a paradigm shift in the understand- of schooling completed the following self-report instruments: The
ing and treatment of various child and adolescent psychological IRI, the Depression, Anxiety and Stress Scales (DASS-21), and the
disorders. Types of Positive Affect Scale (TPAS).
Disclosure of interest.– The authors have not supplied a conflict of Results.– The IRI adolescents’ version showed a four factor struc-
interest statement. ture: Personal Distress (␣ = .67), Fantasy (␣ = .81), Perspective
Taking (␣ = .77), and Empathic Concern (␣ = .54). Gender differences
were found, with girls showing higher scores in all dimensions.
E-PP0063
Age showed a weak positive association only with the Perspective
Green hair in psychiatry – a case Taking dimension. The Personal Distress dimension was positively
report associated with anxiety, depression and stress symptoms, show-
P. Chumpalova1* , V. Valtchev2 , E. Dimitrova1 , L. Tumbev1 , M. ing no association with the types of positive affect. The Perspective
Stoimenova-Popova1 Taking, Fantasy and Empathic Concern revealed low positive asso-
1 Medical University, Psychiatry and Medical Psychology, Pleven,
ciations with positive affects and negative effects with depressive
Bulgaria; 2 National Sports Academy, Biochemistry and Physiology, symptoms.
Sofia, Bulgaria Conclusions.– This study allowed the availability of a reliable and
useful self-report instrument for the assessment of empathy in ado-
lescents, which can be used in clinical, educational and research
Background and aims.– The green hair is a rare dermatological con- contexts.
dition that usually is caused by copper accumulation in the hair Disclosure of interest.– The authors have not supplied a conflict of
from exogenic sources. We present a case of two sisters (skin pho- interest statement.
totype 2 with blond hair), 6 and 8 years old.
Methods.– They have been on a holiday abroad and for 10 days they
have been swimming in a pool. Before the trip they straighten their
hairs with a hair straightener for a first time. The hair of the two
girls was with a green discoloration.
E-PP0065 Results.– There is a relationship between ASD and AN (20–25%).

Use of social networks in the eating This is due to high sensitivity to textures in these patients, to lim-
disorders: descriptive studio ited food preferences or motor disease (severe cases). Besides we
R. De La Mata Hidalgo1* , I. Valriberas2 , D. González3 , M.T. Lozano1 , highlight the inflexible thinking which worse the prognosis of the
G. Sinta1 , N. Casado2 , R. de Alarcón2 , J. de la Iglesia2 , A. Macías4 , A. AN being ASD a chronicity factor in AN. There are limitations in
Bullón1 psychotherapy, knowing that the most behavioral techniques have
1 Neurociencias, Psychiatry, Salamanca, Spain; 2 Ibsal, Psychiatry, better response especially the Applied Behavior analysis.
Salamanca, Spain; 3 Ibsal, Psychiatry. Eating disorder Unit., Conclusions.– In ASD is essential to adapt the therapy to their way
Salamanca, Spain; 4 Neurociencias, Salamanca, Spain of thinking, especially in cases of rigid thinking pathologies such as
* Corresponding author. anorexia nervosa.
Background and aims.– Social media plays an important role in interest statement.
everyday life of young people. Numerous studies claim negative
effects of socialmedia and media in general on eating disorder risk
factors.
The aim of this studie is to examine with a PAWS questionnaire
E-Poster Presentation: Bipolar Disorders - Part IV /
where we have studied the possibilities so far in the field of eating Sleep Disorders & Stress / Substance related and
disorders and the use of social networkings. Addictive disorders - Part III
Methods.– Design: Observational, retrospective, single-center con-
trolled study.
Thirty four participants, recruited from an Eating Disorder Program E-PP0067
in a hospital setting and an eating disorder community support Association between sleep problems
centre, voluntarily participated in focus groups and individual
and suicidal ideations among type I
interviews in 2015.
The next part of the study will be compared with control patients. bipolar disorder patients during
After descriptive statistical analysis consisted of means and stan- euthymia
dard deviation for quantitative variables and percentages for J. Jendoubi1* , F. Fekih-Romdhane2 , B. oueslati3 , O. zeriaa4 , R.
qualitative variables. Between-group differences were calculated ridha3 , M. cheour2
1 Razi hospital, the outpatient service of the hospital Razi, manouba,
with chi-square test or Fisher’s test using IBM SPSS v23.
Results.– The majority of the participants was women between Tunisia; 2 Razi hospital, psychiatric service E, manouba, Tunisia; 3
10–25 years olds that look for information to loss weight in Google, Razi hospital, medico-legal psychiatry service, manouba, Tunisia; 4
Facebook and Instagram specially with and acute moment of the Military Hospital, psychiatry, tunis, Tunisia
disorder.
Conclusions.– Therefore, we believe that we should continue along
the line of designing other alternative communication channels Background and aims.– Bipolar disorder is a severe and frequent psy-
adapted to their current reality. chiatric disease. The interepisode period of bipolar disorder was
Disclosure of interest.– The authors have not supplied a conflict of considered for a long time as asymptomatic. Recent studies have
interest statement. found that sleep-wake disturbances are prevalent during euthymia.
Moreover, the role of sleep disturbances in the development of
suicidal ideations and behaviors has aroused great interest among
E-PP0066 researchers. We aimed to evaluate the links between different sleep
parameters and suicidal ideation and behavior in remitted bipolar
Anorexia nervosa (AN) in adolescent
I patients.
diagnosed with autism spectrum Methods.– 108 remitted bipolar I patients were recruited from
disorder (ASD): case report the psychiatry department of Razi Hospital. The third item of the
P. Del Sol* , Á. Izquierdo, A. Forti, I. Gonzalez-VIllalobos “Hamilton Depression Rating Scale” was used to evaluate cur-
Hospital Universitario Puerta de Hierro Majadahonda, Child and rent suicidal behaviors. Circadian typology, daytime sleepiness
Adolescent Psychiatry, Madrid, Spain and sleep quality were evaluated using the “Horne and Ostberg
Morningness-Eveningness Questionnaire” (MEQr), the “Epworth
Sleepiness Scale” (ESS) and the “Pittsburgh Sleep Quality Index”
Background and aims.– The aim of this case is to show the relation- (PSQI), respectively.
ship of AN and ASD. Results.– Results of the present study showed a high prevalence
Methods.– 15 years old women who is in psychiatric follow- up of sleep-wake disturbances in bipolar I patients during remission.
for two years after her mother’s admission for psychotic episode. Scores of suicidal ideations were significantly and strongly cor-
Fluoxetine 40 mg was given 3 months ago due to sadness and related with scores of circadian typology, daytime sleepiness and
restrictive behaviors. She had normal development, and used cul- sleep quality. We found a positive correlation between sleep quality
tured language since childhood. During infancy she never had and the number of previous suicide attempts after controlling for
symbolic game. She has excellent academic performance. She the associations between demographic variables, sleep medication
describes herself as a very rigid personality, who has troubles and sleep quality scores.
understanding irony and some social behavior. She barely had Conclusions.– An evaluation of sleep’s quality should be included in
friends, referring that having them was a waste of time. She was the suicide risk assessment of bipolar I patients. Clinicians should
very passionate about literature and science. She dressed with carefully explore sleep problems and sleep complaints in remitted
childish clothes. bipolar patients during their follow-up.
The patient described jealousy of her younger sister. She referred Disclosure of interest.– The authors have not supplied a conflict of
that she reduced the food intake to stop growing up and to interest statement.
“have thinner ankles”. Thus she starts a psychotherapy treatment
expressing difficulties to understand what the psychologist meant
because of her excess of literal thought.
E-PP0068 a result of three main factors. The highest impact was from change
Korean medication algorithm for in DDD per patient (q index at 1.41), followed by cost per DDD (p
bipolar disorder: changes in preferred index at 1.18) and last with number of patient (Q index at 1.10). Con-
clusion: prescribing higher dose of antipsychotics to the patients is
medications for mania over 16 years a major factor that impacted the rising of expenditure.
D.I. Jon1* , J.S. Seo2 , B.H. Yoon3 , K.J. Min4 , W.M. Bahk5
1
Conclusions.– Prescribing higher dose of antipsychotics to the
Hallym University Sacred Hearts Hospital, Psychiatry, Anyang,
patients is a major factor that impacted the rising of expenditure.
Republic of Korea; 2 Konkuk University Chungju Hospital, Psychiatry,
Chungju, Republic of Korea; 3 Naju National Hospital, Psychiatry,
interest statement.
Naju, Republic of Korea; 4 Chung-Ang University Hospital, Psychiatry,
Seoul, Republic of Korea; 5 Yeouido St. Mary Hospital- The Catholic
University, Psychiatry, Seoul, Republic of Korea E-PP0070
Addiction in bipolar disorder: risk
Background and aims.– Majority of guidelines for bipolar disorders factors in a cohort of 220 patients
are based on research evidences. The Korean Medication Algo- H. Maatallah* , R. Damak, N. Ghazouani, I. Berrahal, W. Cherif, M.
rithm Project for Bipolar Disorder (KMAP-BP) was developed to Cheour
adopt and maintain an expert-consensus paradigm which was Razi Hospital, Psy E, Tunis, Tunisia
more practical. In this research, preferred medication strategies for
acute mania over five consecutively published KMAP-BP guidelines
(2012–2018) were investigated. Background and aims.– Comorbidity is particularly high in patients
Methods.– The KMAP-BP questionnaire using a 9-point scale had with bipolar disorder BD. Addiction is higher in bipolar patients
covered some specific clinical situations. A written survey asked than in the general population and estimated to range from 25 to
about the appropriateness of various treatment strategies and 60%.
treatment agents. Objectives.– We wanted to investigate risk factors for addiction in
Results.– The most preferred initial treatment strategy for all sub- bipolar disorder (BD) patients.
types of mania was a combination of mood stabilizer (MS) and Methods.– We undertook a retrospective study including a sam-
atypical antipsychotic (AAP) in every edition. In contrast to MS ple of BD type I (DSM IV -TR) out-patients. The inclusion criteria
monotherapy, the preference of combination therapy has been were:hospitalization between January 1 2000 and December 31
increased over time. Among MSs, lithium and valproate were 2015 and at least two years’ follow.
almost equally preferred except in the mixed subtype where val- We examined factors putatively associated with addiction in bipo-
proate was the most recommended MS. Olanzapine, quetiapine, lar patients. Factors were subcategorized into: sociodemographic,
and aripiprazole were the preferred AAP in later editions. This clinical features and commorbidities.
change might depend on the recent researches and safety pro- Results.– A total of 220 adult bipolar out-patients were recruited.
file. In cases of unsatisfactory response, KMAP-BP recommended The mean age was 34.9 years and 60% were male. Addictive behav-
switching or adding another first-line agent. In case of hypomania, ior was about 70%,it was higher in men (80% vs 25%). Alcohol use
MS monotherapy was the first-line strategy in every edition and disorder was about 65% and substance use disorder was 60%. The
was the treatment of choice in 2018. AAP monotherapy was also substance users was characterized by low socio-economic status.
rated as first-line since 2014. The first-line AAP were olanzapine They have a worse global functioning with 80% of unemployment.
and quetiapine in 2006 and aripiprazole was added since 2010. Childhood trauma (p < 0.02) were frequently noted in the substance
Conclusions.– The Korean experts have been increasingly convinced users. The family history of a psychiatric disorder (p < 0.04) and fam-
of the effectiveness of a combination therapy. There have been ily/personal history of suicide attempts (p = 0.03) were significantly
evident preference changes: increased for AAP and decreased for associated to addictive behavior in the two genders. The early onset
carbamazepine. of BD and the high number of depressive episodes were signifi-
Disclosure of interest.– The authors have not supplied a conflict of cantly associated to the substance use disorder (p = 0.02). Comorbid
interest statement. personality disorder was a predictor of addiction in men (p = 0.038),
while anxiety disorder predicted addiction in women (p = 0.04). In
both genders somatic disorder did not predict addiction.
E-PP0069 Conclusions.– Our study confirms the strong associations between
addiction and bipolar disorder,indicating a need for more studies
Factors influencing antipsychotics for
to develop better therapeutic interventions.
bipolar disorder in a thai hospital over Disclosure of interest.– The authors have not supplied a conflict of
ten years interest statement.
R. Kongsakon
Faculty of Medicine- Ramathibodi Hospital, Dep. of Psychiatry,
Bangkok, Thailand E-PP0071
Background and aims.– Bipolar disorder is an illness requiring con- Can lithium salts, in real life, prevent
tinuous use of antipsychotics to control its symptom. In the last
depressive-mixed episodes? data from
decade, the expenditure has been rising. This study aims to exam-
ine factors that influenced its expenditure by using the Laspeyres a long prospective follow-up
index. A. Gonzalez-Pinto González-Pinto1 , P. Lopez1 , C.
Methods.– Retrospective utilization data were retrieved from a Bermudez-Ampudia2 , E. Vieta3 , M. Martinez-Cengotitabengoa4*
1 CIBER-ISCiii- BioAraba Research Institute- University of the Basque
Thai hospital’s database. Changes in antipsychotics expenditure in
Y2008-2012 and 2013–2017 were attributed to two factors: num- Country, Psychiatry, Vitoria, Spain; 2 BioAraba Research Institute,
ber of patient (Q) and cost per patient (P) for each 5-years. By Methodology and Statistics Unit, Vitoria, Spain; 3 Hospital Clinic-
measuring quantity as defined daily dose, changes in P comprised Institute of Neuroscience- University of Barcelona- IDIBAPS-
two sub factors: DDD per patient (q) and cost per DDD (p). CIBERSAM, Psychiatry, Barcelona, Spain; 4 CIBERSAM- BioAraba
Results.– Expenditure on antipsychotics in bipolar patients rose Research Institute- University of the Basque Country, Psichiatry,
from 11.19 to 19.83 million Baht per year from Y2008-2012 to Vitoria, Spain
Y2013-2017 (77.2%). With Laspeyres index, total index of 1.77 was
Background and aims.– Lithium salts continue being the most E-PP0073
important treatment of bipolar disorder (BD). A major problem Similarities and differences between
to achieve its effect is to achieve treatment adherence, because
bipolar smokers and bipolar
reduced adherence is associated with bigger morbidity. Depressive
symptoms in bipolar patients are the most common and difficult-
non-smokers
to-treat ones. The effect of lithium on manic and hypomanic S. Odebrecht Vargas Nunes1* , H. Odebrecht Vargas1 , M. Porcu2
1 State University of Londrina, Clinica Medica, londrina, Brazil; 2
episodes is well established but its effect on depressive-mixed
episodes has not been already measured. Tha aim of the sudy was State University of Maringa, Psychaitry, Maringa, Brazil
to assess the effectiveness of lithium salts in preventing depressive
symptoms, in a sample of bipolar patients followed-up during 10 Background and aims.– Introduction: Bipolar smokers are more
years, considering the adherence to treatment. likely to develop medical and psychiatry comorbidty, more severity
Methods.– Seventy-two patients with BD treated with lithium car- of depressive symptoms and increased levels of leptin and inflam-
bonate were included and followed-up during 10 years. Every 8 matory biomarkers.
weeks a trained psychiatrist assessed their morbidity. Adherence Objectives.– To investigate whether the co-occurrence of bipolar
was rated as good when more or equal than the 90% of bimonthly disorder (BD) and tobacco use disorder (TUD) was associated with
serum lithium assays remained ≥0.50 mEq/L and was verified with severity of symptoms, child abuse, lower quality of life, functional
the “Lithium Attitudes Questionnaire” score. impairment, alterations in the leptin levels, inflammatory biomark-
Results.– Fifty-six patients (77.8%) were considered as good adher- ers, and lipid profile,
ent. Those patients had significantly less episodes with depressive Methods.– Individuals investigated were BD smokers, BD
symptoms, required less hospitalizations during the follow-up, and never–smokers, non-BD smokers, and non-BD never-smokers.
a longer time to relapse than non-adherents. Socio-demographic and clinical data were assessed by structured
Conclusions.– In addition to its known role in the management of questionnaire. Other assessments used were body mass index
mania and hypomania, lithium salts have also a preventive effect (BMI), Hamilton Depression Rating Scale, Hamilton Anxiety Rating
of the occurrence of depressive symptoms in the long-term of BD. Scale, Young Mania Rating Scale, Sheehan Disability Scale, Quality
Treatment adherence should be addressed in order to translate the of Life (WHOQOL-BREF), Childhood Trauma Questionnaire and
efficacy of treatments into effectiveness in clinical practice. laboratoy biomarkers (leptin, high-sensitivity C-reactive protein,
Disclosure of interest.– The authors have not supplied a conflict of soluble tumor necrosis factor receptor 1 and 2, and lipid profile).
interest statement. Results.– BD smokers had significant positive correlation between
leptin levels and emotional abuse, leptin and severity of depression,
leptin and severity of anxiety, leptin and Castelli risk indexes 1 and
E-PP0072
2, emotional abuse and BMI, BMI and triglycerides but a negative
Sexual disorders in females diagnosed correlation between emotional abuse and quality of life.
with bipolar disorder Conclusions.– These findings suggest that bipolar smokers, whose
I. Miclutia1* , L. Damian2 leptin levels were increased, were linked to childhood trauma,
1 University of Medicine&Pharmacy, Neuroscience, Cluj-Napoca, greater severity of depressive and anxious symptoms and
Romania; 2 Municipal Hospital, Ergoterapie, Cluj-Napoca, Romania alterations in components of metabolism. Further studies are rec-
ommended to understand the role of leptin in the pathogenesis of
bipolar smokers.
Background and aims.– There might be at least two main types of Disclosure of interest.– The authors have not supplied a conflict of
sexual disorders recorded in bipolar patients: those emerged by interest statement.
the disorder itself and those provoked by different psychotropic
medication. The first could be recorded before treatment but melt-
ing etiologies make difficult to ascertain these disorders after E-PP0074
treatment administration. Another barrier against the accurate
Does dopamine replacement therapy
description of sexual behaviors in bipolarity might be attributable
to the tremendous disease heterogeneity. induce mania in bipolar patients?
Aims.– To describe the type of sexual disorders recorded in female C. Pinto Ferreira* , I. Pinto, S. Alves, M.J. Avelino
bipolar patients; to establish some predominant patterns of sexual Psychiatric Hospital Centre of Lisbon, Psychiatry, Lisbon, Portugal
disorders according to phases of mood episodes; to point if there is a
relationship of sexual disorders with the severity of mood episodes. Background and aims.– Dopamine replacement therapy (DRT) is the
Methods.– The sample consists of 173 women, 112 being bipo- main treatment of Parkinson’s disease, proved to ameliorate its
lar (81 depressive, 31 manic), and 61 healthy matched controls. motor deficits. Also it can be used to treat patients with Parkinson-
Being a cross-sectional observational study, following psychome- ism, namely caused by antipsychotic drugs when extrapyramidal
tric instruments were given to all subjects: the Sexual disorders symptoms are present. Nevertheless, behavioral disturbances have
interview (SDI), Females Sexual Function Index (FSFI), and BDI, been associated with the use of DRT. The goal of this study is to
YMRS in bipolar patients. systematically review the literature regarding the use of DRT and
Results.– Sexual disorders were detected in the majority of bipolar its effect in patients with bipolar disorder.
patients. Less sexual interest, attributable to depression or medi- Methods.– The authors searched for scientific papers published in
cation, rare sexual intercourse, discomfort, pain were common in ®
the last 15 years, written in English, available in PubMed , using the
depressive patients while manic patients display rather intense
words “Dopamine Replacement Therapy”, “Mania” and “Bipolar” in
sexual fantasies, higher arousal, lubrication, sexual satisfaction.
the Title and/or Abstract.
There could not be established any association between sexual
Results.– Some evidence suggests the induction of hypo-
disorders and the severity of the mood episode.
manic/manic symptoms in non-Parkinson disease (PD) related
Conclusions.– Bipolar women were less sexual active than controls,
bipolar disorder with the use of DRT. Both cases of new-onset mood
various sexual disorders being detected in both groups, but more
elevation and worsening of a previously diagnosed bipolar disor-
disturbing in depression; no association of sexual disorders were
der have been reported. Altogether with corticosteroids, L-dopa
related to the severity of mood disorder.
seems to be the most common prescribed drug associated with sec-
interest statement.
ondary mania. These episodes seem to be reversible, with response Valencia, Spain; 3 Instituto de Salud Carlos III, Centro de Investigación
to decreasing or stopping dopaminergic agents. Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain
Conclusions.– Scientific literature shows that L-dopa may induce * Corresponding author.
mood elevation in bipolar patients without PD. DRT may also be

associated with other behavioral changes like hallucinations, delu- Background and aims.– The influence of different types of variables
sions and confusion. These agents should then be used with caution on the cognitive involvement of Bipolar Disorder (BD) is known.
in all psychiatric patients and specifically in those diagnosed with Aspects related to physical health influence neurocognitive perfor-
bipolar disorder. mance. Recently the research is aimed at assessing the relationship
Disclosure of interest.– The authors have not supplied a conflict of of cardiovascular risk factors and cognition, such as obesity in BD.
interest statement. The Screening for Cognitive Impairment in Psychiatry – Spanish (SCIP-
S) is a test validated as screening for cognitive impairment in
patients with BD5 .
E-PP0075 Our aim is to determine the relationship between neurocognitive
Concentration of VSELs and HSCs in state and anthropometric variables such as the Body Mass Index
(BMI) and abdominal perimeter in a clinical sample of clinically
the peripheral blood in stable bipolar
stabilized outpatient BD patients.
patients, not treated with lithium salts Also, to check whether there is an association with positive screen-
A. Reginia1* , J. Kucharska-Mazur1 , M. Jabłoński1 , M. Tarnowski2 , E. ing for cognitive impairment evaluated with SCIP-S (percentiles
Ferensztajn-Rochowiak3 , J. Rybakowski4 , M. Ratajczak5 , J. ≤15).
Samochowiec1 Methods.– Evaluation by SCIP-S of 118 euthymic patients with BD
1 Pomeranian Medical University, Department of Psychiatry,
according to DSM-5. Analysis of the statistical correlation of the
Szczecin, Poland; 2 Pomeranian Medical University, Department of SCIPS-S scores with anthropometric variables (BMI and abdominal
Physiology, Szczecin, Poland; 3 Poznan University of Medical Sciences, perimeter).
Department of Adult Psychiatry, Poznań, Poland; 4 Poznan University Results.– The SCIP-S total score was statistically significantly cor-
of Medical Sciences, Department of Adult Psychiatry- Department of related to the BMI (p = 0.0048) and the abdominal perimeter
Child and Adolescent Psychiatry, Poznań, Poland; 5 University of (p = 0.0214). No statistically significant relationship was found
Louisville, Stem Cell Institute at James Graham Brown Cancer Center, between positive screening for cognitive impairment evaluated
Louisville, USA with the SCIP-S and these anthropometric variables
Conclusions.– The abdominal perimeter and the BMI are associ-
ated with worse neurocognitive functioning according to SCIP-S
Background and aims.– There is growing evidence of immune acti-
raw score. This study was performed with a short screening instru-
vation in certain psychiatric disorders and their potential influence
ment for cognitive impairment and it does not corroborate a direct
on the process of stem cell mobilization into the peripheral blood,
relationship between body weight and cognitive impairment. How-
as in the case of patients with first episode psychosis. Hence, we
ever, it does confirm that there is a positive relationship between
put forward a hypothesis that mobilization of some types of stem
overweight and worse cognitive functioning in patients with BD.
cells into the peripheral blood may occur in patients with bipolar
disorder (BD).
interest statement.
The aim of the study was to evaluate concentration of VSELs and
HSCs in the peripheral blood of stable BD patients, not treated with
lithium salts.
E-PP0077
Methods.– The study included 30 unrelated individuals with the
diagnosis of bipolar disorder, with disease duration of at least 10 All that glitters is not gold
years, not treated with lithium salts for at least five years prior I.D.L.M. Santos Carrasco* , J.I. Gonçalves Cerejeira, M. De Lorenzo,
to the study. At the time of the study, all patients met the crite- M.D.L.N. Uribe Viloria
ria for bipolar disorder in remission. The control group consisted Resident Doctor, Psychiatry, Valladolid, Spain
of 30 healthy subjects, matched for age, sex, BMI, origin, socio-
demographic factors and nicotine use. Blood samples underwent Background and aims.– This case aims to raise awarenes about the
cytometric analyses to assess concentrations of: VSEL CD34+ (Lin- importance of monitoring blood lithium levels in patients following
/CD45-/CD34+), VSEL AC133+ (Lin-/CD45-/AC133+), HSC CD34+ treatment with this drug.
(Lin-/CD45+/CD34+), HSC AC133+ (Lin-/CD45+/AC133+). Methods.– We present a case of a patient admitted to the Emergency
Results.– Stem cell concentrations in the peripheral blood in the Department due to dizziness, disorientation and worsening of her
patient group were not different compared to the control group. mood. The patient came back to the hospital having her litemia
Conclusions.– There is no evidence of stem cell mobilization into the range about 2.7, so it was necessary to dialyze.
peripheral blood in stable bipolar patients, not treated with lithium Results.– We should use a blood test with any patient treated with
salts. lithium as one of the first tools in our diagnosis.
Disclosure of interest.– The authors have not supplied a conflict of Blood test: Lithium levels = 2.7 mmol/L
interest statement. Blood test after dialysis: Lithium levels = 0,90 mmol/L
Conclusions.– This is a patient who comes to the Emergency Service
with symptoms consistent with lithium poisoning and just using a
E-PP0076
test as simple and efficient as a blood test we could have reached the
Overweight and cognitive diagnosis previously and modify the pattern, ultimately avoiding
performance in bipolar disorder the dialysis.
C. Ribera1* , E. Moreno-Soldado1 , J. Tejera-Nunez1 , V. We must take into account in our differential diagnosis an intox-
Rosello-Molina1 , C. Garcia-Yuste Ribera Viñe1 , A. Ballester-Gil1 , G. ication by this drug when we find a patient who is in a state of
Lera-Calatayud1 , F. Giner-Zaragozá1 , C. Miró-Bujosa1 , J. decompensation, remembering the numerous causes that can alter
Vila-Francés2 , V. Balanzá-Martínez3 , S. Vidal-Rubio1 , S. its absorption. Since lithium is still the first line of treatment in
García-Olmos1 bipolar disorder, we should be aware of the importance of periodi-
1 Hospital Universitario de La Ribera, Psychiatry, Alzira, Spain; 2
cally measuring lithium levels in these patients, thus reducing the
University of Valencia, IDAL - Intelligent Data Analysis Laboratory, frequency of toxicity.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– We report data on 62 demographically matched DSM-IV-
interest statement. TR BD I patients having a current episode, 22 patients with BD-R and
37 HC. All groups were assessed by HAM-D and YMRS. Impulsivity
was measured by BIS-11A and a DDT.
E-PP0078 Results.– In comparison to HC, BD-E patients had significantly
Differences in psychopathology higher BIS-total (p = 0,01), BIS-motor (p = 0,031) and BIS-atten
between offspring of parents with (p = 0,001) subscores. BD-R patients also had higher BIS-total, BIS-
motor and BIS-atten subscores in comparison to HC but these
bipolar I disorder and those with
differences did not reach significance. BD-E and BD-R groups did
bipolar ii disorder: a cross-sectional not differ significantly from each other in respect to their BIS scores.
study Neither the HAM-D score, nor the YMRS score had a significant
S. Shim1* , H. Jung2 , S.W. Hahn3 , J. Yang4 , J.S. Kim1 , Y.S. Lee1 , I.H. effect on the BIS scores. BD-patients did not differ from HC in
Lee2 , M.G. Hwang3 respect to their k-value.
1 Soon Chun Hyang University Hospital, Psychiatry, Cheonan,
Conclusions.– Our results suggest that: 1) BD patients regardless of
Republic of Korea; 2 Soon Chun Hyang University Hospital, their affective state have higher levels of impulsivity in comparison
Psychiatry, Bucheon, Republic of Korea; 3 Soon Chun Hyang to HC, as revealed by BIS; 2) different aspects of impulsivity could
University Hospital, Psychiatry, Seoul, Republic of Korea; 4 Chonbuk contribute to the impulsive behavior in BD patients. Our results
National University Hospital, Psychiatry, Chonju, Republic of Korea support the notion that impulsivity could be regarded as a stable
trait of BD.
Background and aims.– Differences in phenomenology of bipolar
interest statement.
I disorder (BP-I) and bipolar II disorder (BP-II) have remained a
subject of continuous research interest. Despite clinical implica-
tions, few previous studies have evaluated the psychopathology in E-PP0080
offspring considering bipolar subtypes. The aim of this study was
Soft neurological signs in bipolar
to evaluate differences in psychopathology between offspring of
parents with BP-I and those with BP-II. patients in current affective episode
Methods.– The sample included 201 children and adolescents and in remission
between 6 and 17 years of age who had at least one parent M. Stoyanova1* , R. Iakimova2 , L. Hranov2
1 Mental Health Center “Prof. N. Shipkovenski”, Outpatient
with BP-I or BP-II. The offspring were diagnostically evaluated
using the Korean Kiddie-Schedule for Affective Disorders and Department, Sofia, Bulgaria; 2 University Hospital of Neurology and
Schizophrenia-Present and Lifetime Version. Psychopathology and Psychiatry “Sveti Naum”, Second Psychiatric Clinic, Sofia, Bulgaria
Clinical characteristics were evaluated, including DSM-5 main diag-
nosis, comorbidity, depression, anxiety, and childhood trauma.
Differences of lifetime DSM-5 diagnoses between BP-I and BP-II Background and aims.– Soft neurological signs (SNS) are minimal,
were also compared between schoolchildren group aged 6 to 11 objective abnormalities that are supposed to reflect specific cog-
years and adolescent group aged 12 to 17 years. nitive deficits. Recently, many data support the notion that SNS
Results.– In DSM-5 primary and comorbid diagnosis, offspring of could be regarded as endophenotypic markers of bipolar disorder
parents with BP-I had significantly higher rates of MDD and BP-I (BD). The aim of our study was to compare the incidence of SNS in
than offspring of parents with BP-II. The offspring of parents with BD patients manic/mixed episode (BD-M), BD patients in depres-
BP-I had significantly (p = 0.004) higher scores in childhood trauma sive episode (BD-D), BD patients in remission (BD-R) and healthy
scale than those of offspring of parents with BP-II. controls (HC).
Conclusions.– The present study suggests that BP-I and BP-II might Methods.– We report data on 32 demographically matched DSM-
be genetically and etiologically distinct. Our findings indicate that IV-TR BD I patients having a current manic/mixed, 30 BD patients
additional research related to offspring with parents with bipo- having a current depressive episode, 22 BD patients in remission
lar is needed to enhance understanding of multiple dimensional and 37HC with no Axis I or II mental condition. All groups were
differences between BP-I and BP-II. assessed by the Heidelberg Scale.
Disclosure of interest.– The authors have not supplied a conflict of Results.– In comparison to HC, BD-M and BD-D patients had sig-
interest statement. nificantly higher SNS total (p < 0,001), SNS motor (p < 0,001), SNS
sensory (p < 0,001) and SNS complex scores (p < 0,001). Addition-
ally, BD-D patients had significantly higher SNS orientation signs in
E-PP0079 comparison to HC (p = 0,008). BD-R patients had only significantly
higher SNS motor score (p = 0,011) in comparison to HC. There were
Impulsivity in bipolar disorder – a
no inter-group differences in hard signs scores.
state or a trait? Conclusions.– Our results reveal that BD patients irrespective of the
M. Stoyanova1* , R. Iakimova2 , L. Hranov2 affective state (current manic/mixed/depressive episode or remis-
1 Mental Health Center “Prof. N. Shipkovenski”, Outpatient sion) have much more SNS in comparison to HC, i.e. have a discrete
Department, Sofia, Bulgaria; 2 University Hospital of Neurology and neurological dysfunction. Consequently, SNS could be regarded as
Psychiatry “Sveti Naum”, Second Psychiatric Clinic, Sofia, Bulgaria a stable marker of BD.
Background and aims.– Impulsivity is a multifaceted concept and is interest statement.
a prominent feature of bipolar disorder (BD). Whether impulsivity
is state or a trait marker of BD is still controversial. The aim of
the present study was to find out: 1) whether patients with BD
having a current episode (BD-E) and BD patients in remission (BD-
R) are more impulsive in comparison to healthy controls (HC) and 2)
whether the impulsivity level depends on the severity of affective
symptoms.
E-PP0081 bipolar patients. Antipsychotic drugs associated to mood stabilizers

Impulsivity in type I bipolar disorder: were thought to reduce impulsivity levels.
case-control study Disclosure of interest.– The authors have not supplied a conflict of
O. Zerriaa1* , O. Moula2 , A. Bouallagui2 , S. Chebli2 , R. Ghachem2 interest statement.
1 Military Hospital, Psychiatry Department, Tunis, Tunisia; 2 Razi
Hospital, Psychiatry B, Manouba, Tunisia
Metabolic syndrome among patients
Background and aims.– Impulsivity is a key aspect in bipolar dis- taking second generation anti
order that characterizes even the remission phase of the illness. psychotics (SGA): does obstructive
Authors suggest that, impulsivity represents a behavioral expres-
sion of a genetic relation with bipolar disorder, that patients and
sleep apnoea (OSA) and sleep quality
their siblings might share. This hypothesis raises the question of play any role ?
considering impulsivity as an endophenotype of bipolar disorder. P. Avinash Assistant Professor1* , R. Rohatgi2
1 Himalayan Institute of Medical Sciences- SRHU, Psychiatry,
The aims of ths study are to evaluate impulsivity and its different
components in euthymic type I bipolar patients and to compare it Motihari, India; 2 Himalayan Institute of Medical Sciences- SRHU,
with the impulsivity levels of healthy siblings and controls. Psychiatry, Dehradun, India
Methods.– A case-control study conducted on a sample of 30
euthymic type I bipolar patients, 30 healthy siblings and 30 healthy
Background and aims.– Metabolic syndrome is common among
controls. Impulsivity was assessed with the Barrat impulsivity sacle
patients who have been exposed to antipsychotics. Studies have
BIS-11.
found that SGAs may induce weight gain which is one of the risk
Results.– The comparative study found that the patients had higher
factors for Development of OSA. OSA and sleep quality may also
total (p = 0,016), cognitive (p = 0,029) and non planning impulsiv-
contributes to metabolic syndrome.
ity levels (p = 0,025), compared to healthy controls. In addition,
Aims.– To study the contribution of sleep quality and OSA on the
patients showed higher total (p = 0,047) and cognitive impulsivity
development of metabolic syndrome in patients taking SGAs.
levels (p = 0,002) compared with their healthy siblings. However,
Methods.– Total 60 patients taking SGA for more than 3months were
there was no difference noted in impulsivity levels between siblings
taken for the study. It was an observational, cross sectional study.
and controls.
The diagnosis of OSA was done using Berlin Questionnaire and
Conclusions.– In our study, even in euthymic state, bipolar patients
Hindi version of Pittsburg Sleep Quality Index was used to assess
were more impulsive than their siblings and healthy controls. This
the sleep quality. Metabolic Syndrome was diagnosed using Adult
impulsivity did not distinguish the siblings group and thus can’t be
Treatment Panel III criteria from National Cholesterol Education
considered as an endophenotype. It may however represent a pro-
Program.
tective factor explaining the absence of the disease in the siblings
Results.– Forty two subjects did not have metabolic syndrome, out
group.
of which 35 had low risk of OSA and 7 had high risk of OSA. The
results were highly significant with a p-value of 0.007 (p ≤ 0.05).
interest statement.
Subjects without metabolic syndrome (n = 42) comprised 4 good
sleepers and 38 poor sleepers. Subjects with metabolic syndrome
E-PP0082 (n = 18) comprised of 1 good sleeper and 17 poor sleepers. The
results were non-significant with a p-value of 0.525 (p ≥ 0.05). The
Impulsivity in type I bipolar patients high risk of OSA had around 6 times higher likelihood of contribu-
O. Zerriaa1* , O. Moula2 , A. Bouallagui2 , R. Lansari1 , R. Ghachem2 tion to metabolic syndrome.
1 Military Hospital, Psychiatry Department, Tunis, Tunisia; 2 Razi Conclusions.– Sleep quality did not play a role in increasing the like-
Hospital, Psychiatry B, Manouba, Tunisia lihood of metabolic syndrome and OSA increased the likelihood of
metabolic syndrome in subjects exposed to SGAs by six times.
Background and aims.– Trait impulsivity is increased in type I bipolar Disclosure of interest.– The authors have not supplied a conflict of
patients through all phases of the illness. It may be considered as a interest statement.
core feature of the disease.
The aim of this study is evaluate impulsivity and its correlations
E-PP0084
with sociodemographic, clinical and therapeutic characteristics of
bipolar patients. Associations between salivary
Methods.– The subjects completed forms collecting sociodemo- markers of stress system activation
graphic, clinical and therapeutic data, Barrat Impulsivness Scale with social withdrawal in humans
(BIS-11) in Arabic version, Beck Depression Inventory (BDI), Young S. Bauduin1* , E. Giltay1 , M. van Noorden1 , S. van der Werff1 , M. de
Mania Rating Scale (YMRS) and the Mini International Neuropsy- Leeuw2 , A. van Hemert1 , N. van der Wee1
chiatric Interview version 5 (MINI-5) to screen for substance and 1 Leiden University Medical Center, Psychiatry, Leiden, The
alcohol misuse. Netherlands; 2 GGZ Rivierduinen, Psychiatric Outpatient Clinic,
Results.– The exposure to childhood trauma was associated with Leiden, The Netherlands
higher motor impulsivity scores (p = 0,028). Bivariate study showed * Corresponding author.
a significant correlation between suicide attempts history and
total (p = 0,001; r = 0,593), motor (p = 0,015; r = 0,440) and non plan- Background and aims.– Social withdrawal (SW) is an early symp-
ning impulsivity (p = 0,004; r = 0,515). Mixed episodes seemed to tom of stress-related psychiatric disorders. Associations between
be also correlated with total (p = 0,010; r = 0,463), motor (p = 0,008; SW and the hypothalamic-pituitary-adrenal (HPA) axis have been
r = 0,478) and non planning impulsivity (p = 0,042; r = 0,374). The previously established. However, the relationship between salivary
association of antipsychotic drugs with mood stabilizers was cor- alpha-amylase (sAA; an enzyme reflecting autonomic nervous sys-
related to less total (p < 0,001), motor (p = 0,001) and non planning tem activation) and SW have not been investigated to date.
impulsivity levels (p = 0,007). Methods.– In this cross-sectional, observational study, saliva sam-
Conclusions.– In our study, impulsivity was associated with child- ples were collected over two days in 843 participants (231
hood trauma, suicide attempts history and mixed states in type I psychiatric patients and 612 healthy controls) that participated in
routine outcome monitoring (ROM). SW was determined on the much controversy over the clinical significance of PLMS. The aim
basis of 3 relevant ROM subscales, and the relationship between of study was to investigate the prevalence and impact on sleep of
salivary cortisol (sC) and sAA with SW was investigated by means PLMS in the elderly population in Republic of Korea.
of multivariate linear regression analyses. Mediation analyses were Methods.– A cross-sectional and community-based study was
run to determine the possible mediating role of SW in the relation- conducted in the city of Yongin-si,south Korea. Among 6,959 indi-
ship between sC, sAA, and depression scores on the Montgomery viduals aged 60 years or older, 696 subjects were selected using
Asberg Depression Rating Scale (MADRS). systemic random sampling. All the subjects were invited to visit
Results.– On average, participants were 44.0 years old and 64.1% University Hospital for overnight polysomnographic study. Peri-
were female. After adjustment, statistically significant positive odic leg movements were scored using the American academy
associations were only found between sC and one of the social of sleep medicine manual. Subjective sleep complaints,daytime
withdrawal subscales at certain specific time points (area under the sleepiness, cognitive function and depressive symptoms were
curve with respect to the increase, beta = 0.082, p = 0.02; evening sC assessed using Pittsburgh Sleep Quality Index (PSQI), etc. Insomnia
value: beta = 0.110, p = 0.003; mean sC value: beta = 0.097; p = 0.01), was diagnosed according to the criteria of DSM-IV-TR.
however not with any of the other subscales. Results.– Of the 696 subjects sampled, 354 completed overnight
Conclusions.– HPA-axis activity, but not ANS-axis activity is associ- PSG. Six subjects who sleep less than 3 hours were excluded from
ated with social withdrawal. analysis and 348 subjects (135 male,213 female,mean age 68.35.6
Disclosure of interest.– The authors have not supplied a conflict of years old) were analyzed. Final responserate was 50.0%. The preva-
interest statement. lence of periodic limb movement during sleep (PLM index > 15) was
29.3%(male: 24.1%,female 33.5%). There was no significant effect of
PLM index severity for polysomnographic sleep parameters and
E-PP0085 subjective sleep quality. The subjects with insomnia, compared
Sleep disorders in patients with to ones without it, showed higher PLMA and women predomi-
multiple sclerosis nance. Higher PLMA was independently related with insomnia after
M. Chakroun* , S. Sakka, O. Hdiji, N. Farhat, H. Haj Kacem, M. adjustment for gender.
Dammak, C. Mhiri Conclusions.– The PLMS prevalence of 29.3% in this study was com-
Habib Bourguiba University Hospital, Department of Neurology, Sfax, parable to those of previous studies. PLMS has little impact on
Tunisia nocturnal sleep quality and daytime sleepiness,but PLMA > 5 may
* Corresponding author. increase the occurrence of insomnia more than twice.
Background and aims.– Multiple sclerosis (MS) is associated with
interest statement.
a diverse range of physical, cognitive, emotional, and behavioral
symptoms. Sleep disturbance is a very common, yet underdiag-
nosed problem. E-PP0087
Aims.– To assess the prevalence of poor sleep and investigate the
Genetic analysis of high-risk/low-risk
factors that influence sleep quality of patients with MS.
Methods.– A cross-sectional and analytical study was carried out alcohol addiction phenotypes
on 31 patients with MS, followed up in the neurology department T. Duarte* , J. Gonçalves, I. Duarte Silva, P. Câmara Pestana, S.
of Habib Bourguiba hospital, Sfax, Tunisia, over a period of four Pombo
months. Demographic data, duration of the disease and the disease Hospital de Santa Maria - Centro Hospitalar Lisboa Norte- E.P.E.,
course were extracted from patients’ medical files. The quality of Serviço de Psiquiatria e Saúde Mental, Lisboa, Portugal
sleep was evaluated by the Pittsburgh Sleep Quality Index (PSQI)
and the insomnia severity index (ISI), anxiety and depression by Background and aims.–
the Hospital Anxiety and Depression Scale (HADS), the severity of Introduction.– A growing body of scientific research has estab-
fatigue symptoms by the Fatigue Severity Scale (FSS) and the level lished the value of Cloninger alcoholism typology. Type I alcoholism
of disability by the Expanded Disability Status Scale (EDSS). requires the presence of a genetic as well as an environmental pre-
Results.– The average age was 34, 19 ± 10 years old with an average disposition, affects both men and women (“milieu-limited”) and is
age at the onset of the disease 25, 06 ± 5,7 years. Relapsing remit- the most common type. Type II alcoholism, the less common type,
ting MS occurred in 80, 6% of cases. The prevalence of insomnia was is strongly influenced by genetic factors and affects mainly male
61, 3% with a delay of falling asleep in 25,5%. The average number individuals (“male limited”).
of hours of sleep was 6, 8 ± 3 hours. Insomnia was significantly cor- Objectives.– Examine the association of candidate genes of the
related to depression (p = 0,001), anxiety (p = 0,000), fatigue (p = 0, monoamine neurotransmitter pathways with the alcohol addiction
01) and anti-depressant medication use (p = 0,026). phenotype, classified according to Cloninger et al. (1981) model.
Conclusions.– Poor sleep is more common in patients with MS than Methods.– A case-control study was performed with 127 alcohol-
in the general population. Sleep disorders should routinely be eval- dependent patients and 105 healthy controls. Study participants
uated in patients with MS to improve the quality of sleep among were recruited in the alcoholism unit of Santa Maria University Hos-
them. pital in Lisbon. Patients were subtyped into type I (N = 100) and type
Disclosure of interest.– The authors have not supplied a conflict of II (N = 27) with a clinical algorithm. Mini Neuropsychiatric Inter-
interest statement. view was used for diagnostic evaluation. Genotyping was done by
polymerase chain reaction. Genotype and allele frequencies were
compared using Fisher’s exact test. The 95% confidence interval was
E-PP0086
used to estimate the precision of the Odds Ratio. Data were analysed
The prevalence and impact on sleep of using the SPSS (Version 20.0). Statistical significance was defined
periodic limb movements during at p < 0.05. All the observed genotype frequencies did not deviate
sleep in the elderly from Hardy-Weinberg equilibrium.
M.Y. Chung Results.– The frequency of the S allele of the 5-HTTLPR poly-
Worker’s Compensation Hospital/Yonsei Univ. College of Medicine, morphism was significantly higher in the subtype II (0.90) when
Dept.of Neuropsychiatry, Seoul, Republic of Korea compared to subtype I (0.62) and the control population (0.69)
Background and aims.– Periodic limb movements during sleep (p = 0.05; OR = 0.23, 95% CI = 0.05–1.1).
(PLMS) are common in the elderly population but there remains
Conclusions.– We may conclude that some classification systems of der and / or a Post-Traumatic Stress Disorder (PTSD) was assessed
alcohol addiction appear to possess a greater ability in capturing using the shortened Beck Depression Inventory (BDI) and PTSD
certain genetic influences than others. Check-List 5 (PCL-5) scales, respectively.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The mean age of our population was 37.47 years old.
interest statement. Twenty-five percent consumed alcohol with a mean score of 4.98
at the AUDIT scale. Forty-five percent of patients had PTSD with a
mean score of 33,6 at PCL-5 scale. Patients had mild depression in
E-PP0088 11% of cases; moderate in 30% of cases and severe in 25% of cases.
Plasma BDNF in relevance to cognitive We didn’t find a significant association between alcohol misuse and
functions in chronic heroin users PTSD nor depression.
S. Elghonemy* , A.E. Soliman, N. Zaki, R. ElGhamery, M. Farag Conclusions.– Alcohol misuse is quite common in the military.
Soliman Screening for early signs of alcohol misuse is important to identify
Ain Shams University, Neuropsychiatry Department, Cairo, Egypt individuals at risk prior to exposure to combat-related trauma.
* Corresponding author. Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
Background and aims.– Opioid abuse is a wide spread phenomenon
worldwide. Few studies reported cognitive deficits in patients with
chronic substance abuse with no consistent pattern of cognitive E-PP0090
deficits especially among the patients with heroin abusers. Validation of the severity of
Objective.– To determine the pattern of the cognitive dysfunction dependence scale-general (SDS-G) in a
in Egyptian patients with chronic heroin users and its relation to
sample of the Portuguese population
BDNF plasma level.
H. Espírito-Santo* , C. Madeira-Sério, C. Duarte, L. Lemos
Methods.– Thirty patients with chronic heroin use were selected
Instituto Superior Miguel Torga, Psychology, Coimbra, Portugal
from inpatient unit and outpatient clinics in Institute of Psychiatry- * Corresponding author.
Ain Shams University and were evaluated for cognitive function,
compared with 30 healthy frequency matched controls. They were Background and aims.– The SDS was developed to assess the degree
subjected to the following; SCID-I, The severity of addiction was of dependence of different types of drugs. We aimed to validate
assessed, battery of neuropsychological tests was introduced for a new extended SDS that assessed other addictive behaviors in a
assessing the cognitive functions and laboratory evaluation to BDNF sample of the Portuguese population.
plasma level was done. Methods.– 342 participants (age: M ± SD = 25.25 ± 7.87 years; sex:
Results.– patients with heroin use showed worse cognitive domains 61.4% men) filled a sociodemographic-clinical questionnaire and
of total intellectual functions, visual, verbal, immediate mem- the SDS-G in an internet survey. The instruction was “Indicate the
ory and executive function. Meanwhile, a statistically significant degree of dependence on something you cannot live without (drug,
higher plasma level of BDNF was found among cases. There was no gambling, exercise, eating, social-networking, drinking, shopping,
statistical significance between BDNF plasma level and different masturbating, interneting, smoking, watching TV shows, etc.)”. The
neuro-cognitive functions. five items, scored on a 4-point scale, were: 1) Do you think your
Conclusions.– Patients with chronic heroin use were suffering from dependence was ever out of control? 2) Does the prospect of not
dysfunction of multiple cognitive domains that could be detected having/being stopped of doing/using/consuming the object of your
by neuropsychological tests. Moreover, BDNF is one of the patho- dependence at the moment you were counting on it make you anx-
physiological factors that has role in addictive behaviors and ious or worried? 3) To what extent were you concerned about your
continued drug use and relapse. dependence? 4) Did you ever wish you could stop? 5) To what
Disclosure of interest.– The authors have not supplied a conflict of extent do you think will be difficult to stop your dependence?
interest statement. Results.– Cronbach’s alpha was 0.86 with a one-factor struc-
ture explaining 64.5% of the variance (Kaiser-Meyer-Olkin = 0.85;
Bartlett’s test of Sphericity: p < .001). SDS-G correlated with use
E-PP0089 frequency of alcohol, hallucinogenic, cannabinoid, club, stimulants
Evaluation of alcohol consumption drugs (r = 0.16; p < 0.01), and tobacco (r ranging from 0.13 to 0.35;
among military psychiatric p between .05 and .001).
consultants Conclusions.– The preliminary results indicate that the SDS-G is
F. Ellouze* , M.W. Krir, R. Jouini, C. Ati, I. Bouzouita, H. Elkefi, A. a valid instrument for the general population. Future directions
Oumaya include the replication with clinical samples.
Military hospital, Psychiatry department, Tunis, Tunisia Disclosure of interest.– The authors have not supplied a conflict of
* Corresponding author. interest statement.
Background and aims.– Traditionally alcohol has been used by the

military to cope with the intense stress of battle but also as a E-PP0091
way of mediating the transition from the heightened experience Smoking cessation in serious mental
of combat to routine safety. However, a striking range of alcohol- illness: a multi-pronged approach
related behaviors could be classified as injurious. At one extreme
using the treatment cascade
are behaviors that are clearly dangerous to both physical and men-
tal health. framework
The aim of this study was to assess alcohol consumption among mil- O. Freudenreich1* , S. MacLaurin2 , K. Irwin1 , C. Cather1 , C. Cieslak1 ,
itary psychiatric consultants and to determine factors associated S. Paudel1 , L. Donahue3 , C. Mulligan2 , M. Ujkaj4
1 Massachusetts General Hospital, Psychiatry, Boston, USA; 2 Erich
with alcohol misuse.
Methods.– This is a cross-sectional study involving 73 patients Lindemann Mental Health Center, Mental Health, Boston, USA; 3
followed at the psychiatric outpatient military clinic “Meftah Saâ- Brookline Community Mental Health Center, Mental Health,
dallah” during the period between February and March 2018. The Brookline, USA; 4 North Suffolk Mental Health Association, Mental
Alcohol Use Disorders Identification Test (AUDIT) scale was used to Health, Chelsea, USA
evaluate alcohol consumption. The presence of a depressive disor-
Background and aims.– Nicotine dependence contributes signifi- Conclusions.– According to the above results, the most striking find-
cantly to medical mortality in patients with serious mental illness. ing focuses on the Lesch type III patients (alcohol abuse for its mood
Reducing smoking in this population has been less successful than enhancing and sleep inducing properties), which is more likely
in the general population. A system-wide effort addressing the var- to coexist with perceived dominant views from partners. Future
ied obstacles to smoking cessation is needed to improve this health research should further investigate other confounding factors that
disparity. may influence the relationship between attitudes of important oth-
We introduce the treatment cascade framework and apply it ers and Lesch types.
to nicotine dependence. We then show how this conceptual Disclosure of interest.– The authors have not supplied a conflict of
framework can guide program development to address smoking interest statement.
cessation in patients with serious mental illness.
Methods.– Using quality improvement projects, we reviewed smok-
ing histories and treatments for patients in a community mental E-PP0093
health clinic, including a clozapine clinic. Focus groups with clini- Risk factors for wernicke-korsakoff
cal staff and psychiatry residents identified obstacles to addressing syndrome in patients with alcohol use
smoking cessation.
disorder. A series of five cases
Results.– 37% of 197 clozapine patients were current smokers; 32%
A. Giménez Palomo1* , J.E. Pinzón1 , G. Anmella1 , L. Espinosa2 , S.P.
had quit. Smoking status, and history, was not uniformly reported
Gomes1 , G. Mayà3 , P.R. Guzmán1 , N. Freixa4 , M. Balcells1
in the electronic medical record, thereby preventing population- 1 Hospital Clínic of Barcelona, Psychiatry, Barcelona, Spain; 2
based management for the whole clinic. Even motivated patients
Fundació Althaia - Manresa, Psychiatry, Barcelona, Spain; 3 Hospital
could not easily be linked to the full spectrum of care, particu-
Clínic of Barcelona, Neurology, Barcelona, Spain; 4 Hospital Clínic of
larly psychosocial interventions. There was no mechanism to track
Barcelona, Psychology, Barcelona, Spain
patients who had quit longitudinally. Less than 50% of patients who * Corresponding author.
quit had received evidence-based pharmacological treatments.
Conclusions.– Using the treatment cascade framework, we iden- Background and aims.– Wernicke-Korsakoff Syndrome (WKS)
tified several critical gaps in our clinic: lack of uniform and is a prevalent residual syndrome in patients with Wernicke
complete data entry; lack of easy linkage to provider with exper- encephalopathy who did not receive immediate treatment with
tise in smoking cessation; lack of consistent follow-up of motivated thiamine replacement. This syndrome entails profound cognitive
patients; and limited use of evidence-based treatments for smok- impairments and loss of functionality.
ing cessation. Quality improvement projects including educational A series of five cases admitted to our Acute Psychiatric Ward with
initiatives are underway to address identified barriers to successful this diagnosis is presented. As a whole, they had different risk fac-
smoking cessation. tors for WKS apart from alcohol use disorder.
Disclosure of interest.– The authors have not supplied a conflict of Case 1: 57 year-old man with history of bariatric surgery who is
interest statement. admitted from a suicide attempt by precipitation. Case 2: 60 year-
old man derived by court order due to behavioral disturbances
and alcohol abuse. Case 3: 42 year-old woman with anorexia ner-
E-PP0092 vosa and chronic renal failure who is hospitalized after presenting
Perceived parents’ and partners’ hematemesis. Case 4: 55 year-old man with history of HIV infection,
attitudes towards female women with dilated myocardiopathy and chronic renal failure who is admitted
alcohol dependence: do they really for alcohol cessation. Case 5: 43 year-old man with substance use
disorder and HIV infection who is derived due to auditive halluci-
matter?
nations and aggressiveness.
V. Giannouli1* , D. Ivanova2
1 Methods.– In all cases, diagnoses were performed clinically, follow-
Organisation Against Drugs, Okana, Athens, Greece; 2 South-West
ing the detection of mental state disturbances, nistagmus, ataxia
University “Neofit Rilski”, Department of Psychology, Blagoevgrad,
and memory impairments. In cases 1, 2 and 3, a magnetic resonance,
Bulgaria
* Corresponding author. a extension study of the neoplasia and a cognitive assessment were
performed respectively.
Background and aims.– The aim of this research is to examine Results.– Thiamine replacement therapy at high doses was started
whether specific subtypes of alcohol dependence according to in all cases.
Lesch typology in women from Southern Bulgaria are more likely Conclusions.– WKS is commonly underdiagnosed worldwide. Its
to coexist with specific perceived attitudes in parents and partners. early diagnosis and treatment are crucial given the associated mor-
Methods.– The study included fifty-three women bidity and mortality and the demonstrated possibility of preventing
with a diagnosis of alcohol dependence (Mage = 43.84, WKS in patients with Wernicke encephalopathy.
SDage = 9.48; Myears ofeducatio n = 15.11, SDyears of educatio n = 3.21; Clinicians should be able to identify the different risk factors for
Myears of addiction 12, SDyears of addictio n = 3.56, all raised by their WKS.
parents and with partners at the time of the examination). All Disclosure of interest.– The authors have not supplied a conflict of
were evaluated with the Bulgarian version of the Lesch Alcoholism interest statement.
Typology – Questionnaire (LAT), while data were collected with
self-report questionnaires regarding their parents’ attitudes. The
questions regarding their parents’ attitudes included close-ended E-PP0094
categorization (loved, not loved, not judgmental) and their part- Serial estimation of urine ethyl
ners’ attitudes were again rated in a close-ended way (categories: glucuronide (ETG) and ethyl sulfate
dismissive, dominant, inconspicuous, insecure). All questions were (ETS) during monitored abstinence in
answered by the patients.
alcohol dependence syndrome
Results.– Chi-square tests indicated that no interaction exists for
S. Huddar1* , P. Murthy2 , P.K. Chand2 , P. Sharma2 , L. Shukla3
parents’ attitudes and Lesch types (x2 (4) = 4.341, p = .362), but a 1 Senior Resident, Department of Psychiatry- SDM Medical College
significant interaction was found for partners’ attitudes and Lesch
and Hospital- Dharwad, HUBLI, India; 2 National Institute of Mental
typology (x2 (6) = 13.507, p = .036).
Health and Neurosciences, Centre for Addiction Medicine-
Department of Psychiatry, Bengaluru, India; 3 All India Institute of E-PP0096

Medical Sciences, Department of Psychiatry, Bhopal, India Nutritional status in patients under
methadone maintenance treatment
Background and aims.– Alcohol use disorders are recognized world (MMT)
over as a major public health issue. Thus, an urgent need for early A. Kheradmand* , A. kheradmand
identification of risk factors and timely management has been long Shahid Beheshti Medical University, Psychiatry, Tehran, Iran
felt in addiction treatment research. The role of biomarkers has
proved to be important in the identification of problem drinking
Background and aims.– Methadone maintenance treatment (MMT)
and in monitoring relapse. Urine EtG and EtS are direct biomark-
is an effective therapeutic modality for opiate addiction, beside the
ers of alcohol helpful in detection of recent alcohol use. This study
success of MMT on addiction; it can also cause some behavioral
focuses on understanding the pharmacokinetics of urine EtG and
habits during treatment like poor dietary habits. So the aim of the
EtS.
present study has been to evaluate the food frequency in Iranian
Aims and Objectives.– To characterise time course of urinary EtG and
patients under methadone maintenance therapy.
EtS during abstinence in alcohol dependent patients.
Methods.–
Methods.– Information regarding alcohol use was collected using
Patients and methods.– In this cross-sectional study, 198 adult
self-report measures among 100 subjects. Urine EtG and EtS was
subjects under MMT for more than 6 months were enrolled. Mea-
monitored serially in each subject sixth hourly for 72 hours.
surement tool consisted of Food Frequency Questionnaire (FFQ),
Results.– Median urine EtG and EtS levels approach zero at the end
and a demographic questionnaire. The questionnaires were self-
of 48 hours and 42 hours respectively. The percentage change in
completed, except where individuals were illiterate.
urine EtG and EtS is exponential and does not follow linear order
Results.– Mean age of the subjects was 41.2 ± 7.9 years and 93.4%
kinetics. Sensitivity and specificity of urine EtG at cut off of 300
of them were male. More than half of them used heroin. Rarely
ng/ml is 93% and 100% respectively. Similarly, for urine EtS at cut
or never times of using for soya and nuts in patients under MMT
off of 100 ng/ml sensitivity is 91% and specificity at 100%.
were 46.5% and 40.4% respectively, for seafood and vegetables were
Conclusions.– Urine EtG and EtS can be best detected within
27.3% and 28.3% sequential. Seldom usage of dairy was different
48 hours of last alcohol use with high sensitivity and specificity and
from 21.7% for milk to 2.0% for yogurt. Unlikely water and bread
these biomarkers provide valuable information of recent alcohol
were using more frequently in patients under MMT.
use.
Conclusions.– Patients under methadone maintenance treatment
had increased consumption of simple carbohydrates which can
interest statement.
cause remarkable gain in the mean calorie intake and body weight.
Further studies are needed to clarify whether opioid dependent
E-PP0095 patients should go on a diet during long term treatment or not.
Validation of the persian version of interest statement.
the smart phone addiction scale
among Tehran university students
A. Kheradmand1* , E. Amirlatifi2
1 Shahid Beheshti University of Medical Sciences, Taleghani Hospital E-Poster Presentation: Bipolar Disorders Part I /
Research Development Committee, Tehran, Iran; 2 Shahid Beheshti Substance related and Addictive disorders I
University of Medical Sciences, Medical School, Tehran, Iran
E-PP0097
Background and aims.– Smart phone addiction is a recent phe-
nomenon which has been rising tremendously as new applications
From a potential treatment to
being published specially in Southeast Asia. Iranian users play a probable harm: a case series of
noticeable part in utilizing this new technology. This research con- pregabalin withdrawal syndrome
ducted to evaluate psychometric characteristics of smart phone A. Eid El Aghory1 , M. Abdelghani2* , A.R. Hammad1
1 Ministry of Health, Abbassia Hospital for Mental Health, Cairo,
addiction scale in Persian population.
Methods.– This was a cross-sectional study which was conducted Egypt; 2 Zagazig University, Psychiatry, Zagazig, Egypt
in 2017. The Persian SAS and Internet addiction test (IAT), which is
already validated in Iran were fulfilled by 200 students of Tehran
universities who were selected with multistage sampling. Background and aims.– Pregabalin has been increasingly used
Results.– Pearson correlation coefficient was 0.7 (P = 0.00), which during detoxification programs to alleviate drug withdrawal symp-
shows that there is strong positive correlation between Persian SAS toms and craving, especially with alcohol and opioid use disorders.
and Persian IAT. The optimal cut-off score for identifying at-risk Over more than a decade, pharmacovigilance reports and case
cases was more than 106, with a sensitivity of 80%, a specificity of studies have provided information on the presence of a probable
86%. Cronbach’s alpha coefficient for the total scale was 0.93. Test- “pregabalin use disorder, PUD,” with overdose mortality reported
retest reliability of Persian SAS is high with Interclass correlation in opioid maintenance programs.
0.996. Methods.– Unpleasant withdrawal symptoms during pregabalin
Conclusions.– Persian SAS is a valid and reliable tool for examining use were described in six Middle-Eastern young adult male patients
smart phone addiction in Iranian society. (21 to 31 years old), who have a clinically-validated PUD, alone or
Disclosure of interest.– The authors have not supplied a conflict of with other substances.
interest statement. Results.– Duration of pregabalin use ranged between two to
six months. Total daily dose varied between 1500 mg to
4500 mg. Observed withdrawal symptoms were psychological (e.g.,
depressed or irritable mood, sense of restlessness, social with-
drawal, reduced spontaneous speech), autonomic (e.g., diaphoresis,
sense of being cold, GI upset), fatigue, chest pain, and tremors.
Conclusions.– Pregabalin has a rising “use disorder” pattern in the Aims.– To identify the major psychiatric factors among an inpatient
Middle-Eastern region, with withdrawal syndrome, that is distinc- population with TC versus other Non-Ischemic cardiomyopathies
tive from other substances. Risk of addiction liability was observed (NICM).
even without a history of other substance use disorders. Use of pre- Methods.– We searched 2012-15 inpatient Problem Lists for NICM
gabalin might warrant clinical attention during the healthcare of and TC (Mayo Criteria) related cardiomyopathies and confirmed 68
patients with substance use disorders, notably the sedative ones, diagnosed cases. These were evaluated for psychiatric comorbid-
or patients with risk factors for addiction. Further longitudinal stud- ity and indicators of substance abuse. Subjects diagnosed with TC
ies need to investigate the evolution of pregabalin use as a separate (n = 32) were compared to those with other NICM (Non-TC, n = 36).
substance use disorder. Results.– Females were more likely to meet TC criteria than males
Disclosure of interest.– The authors have not supplied a conflict of (66.7% vs 28.6%, P = 0.003). Patients with depression and/or anxi-
interest statement. ety were more commonly diagnosed with TC than without, (70%
vs 43.1%, P = 0.172, and 64.3% vs 42.6%, P = 0.229, respectively). A
higher proportion of patients with opioid use history met criteria
E-PP0098 for TC, relative to those without any history (64.9% versus 25.8%,
Motivation as a focus in the treatment Odds ratio = 5.2, P = 0.002).
of alcohol use disorders Conclusions.– Our sample confirms female gender, anxiety and
H. Afonso* , J. Gomes, G. Lima depression as characteristics often reported with TC. However,
Centro Hospitalar do Barreiro Montijo, Psychiatry and Mental Health, our underserved inpatient population with diverse psycho-social
Barreiro, Portugal stressors also suggests an additional association with opioid use.
* Corresponding author. The etiology of this is not clear, but QTc prolongation is another
reported risk factor for TC and chronic opioid use can cause QTc pro-
Background and aims.– Additive behaviors may be addressed, in longation. Further research is needed to categorize the association
clinical practice, with motivational focused strategies. Those inter- of TC with psychiatric co-morbidity as well as define its possible
ventions focus in addressing the ambivalence that the patient is relationship to chronic opioid abuse.
experiencing and, through motivational strategies, stimulating him Disclosure of interest.– The authors have not supplied a conflict of
to strengthen and develop the necessary motivation for change. interest statement.
Through this process the patient consequently progresses in the
stages of change and develops the means to modify its behavior.
The basis for this are openness, neutrality, empathy and respect. E-PP0100
While given the means to change, the patient’s autonomy is always Mood disorders in patients with
respected. Through this process, the patient is stimulated to address acromegaly and cushing’s disease
its problem while maintaining its autonomy and to develop the M. Alexandrova1* , D. Almaev2 , E. Starostina3 , Z. Belaya4 , A.
need tools for change. Bobrov5
This work aimed at evaluating the use of motivational based strate- 1 Institute of Psychotherapy and Clinical Psychology, Educational
gies in the treatment of alcohol use disorders. department, Moscow, Russia; 2 N.A. Alekseyev First Psychiatric
Methods.– The authors did a non-systematic review of the relevant Hospital, Out-Patient Psychiatric Facility №13, Moscow, Russia; 3
papers addressing this theme on the literature. Pubmed and Sci- Moscow Regional Research and Clinical Institute, Endocrinology
encedirect search engines were used to select the papers used and Department, Moscow, Russia; 4 Endocrinology Research Centre,
the relevance of those was evaluated by the authors. Neuroendocrinology and Bone Diseases, Moscow, Russia; 5 Pirogov
Results.– Literature shows support for motivational oriented strate- Russian National Research Medical University, Department of
gies in the treatment of additive behaviors, including alcohol use Psychiatry Faculty of Postgraduate Education, Moscow, Russia
disorder, even with brief interventions using this model. * Corresponding author.
Conclusions.– In alcohol use disorder, a focus on motivation may
provide the necessary momentum for change. Motivational inter- Background and aims.– Previous studies have shown high preva-
view gives some tools that allow the patient to develop this lence of mood (mostly unipolar) disorders in patients with
necessary force for inner change. Literature seems to support this endocrine diseases. There are nonsystematic data on bipolar spec-
kind of strategy for the treatment of additive disorders. Moti- trum disorders in patients suffering from Cushing’s disease (CD)
vational interview may be a interesting tool for addressing this and single case reports about mania states in patients with
problem. acromegaly.
Disclosure of interest.– The authors have not supplied a conflict of Aims.– To study prevalence of mood disorders in patients with
interest statement. acromegaly and CD.
Methods.– The study involved 115 patients with acromegaly (95
women/20 men, aged 55 ± 13), and 94 patients with CD (84/10,
E-PP0099 41 ± 12). Mental health was evaluated with structured psychiatric
Association of psychiatric and opioid interview (MINI 6.0) and ICD-10 criteria. In the majority of patients
use disorders with takotsubo who had affective disorder hypomania checklist (HCL-32) was also
used.
cardiomyopathy in an urban
Results.– Affective disorders were diagnosed in 47/115 (40,9%)
community hospital inpatient setting patients with acromegaly and 56/94 (59,6%) CD patients.
M. Ahmad* , G. Levitt, B. Bhattarai, G. Ramos Their spectrum included: hypomania in 5(4,3%) patients with
Maricopa Integrated Health System, Psychiatry, Phoenix, USA acromegaly and 11(11,7%) CD patients; mania in 0 and 3(3,2%)
patients, respectively; bipolar disorder in 20(17,4%) and 24(25,5%);
Background and aims.– Takotsubo cardiomyopathy (TC) is a non- other unspecified bipolar disorders (type IV mostly) in 14(12,2%)
ischemic stress-induced response of heart muscles that although and 0; depressive episode 3(2,6%) - 8(8,5%); recurrent depression
largely reversible, is often invasive and costly to differentiate from 6(5,2%) – 5(5,3%); cyclothymia 2(1,7%) - 5(5,3%). In 42/47 patients
acute coronary syndrome. The role of emotional and physical trig- with acromegaly and 39/56 CD patients who had mood disorder
gers in the etiology of TC remains unclear. the HCL-32 was used. 31/42(73,8%) patients with acromegaly and in
29/39(74,4%) CD patients scored ≥ 14, that was indicative of bipolar
type II disorder.
Conclusions.– Study confirms high frequency of mood disorders in leaves of the N,N-dimethyltryptamine (DMT)-containing Psycho-
patients with acromegaly and CD. High prevalence of bipolar spec- tria viridis, which acts as a potent agonist to 5-HT2a receptors.
trum disorders in both groups probably can be associated with Drinking ayahuasca has recently become very popular in shaman-
dysregulation at suprapituitary level, suggesting that these dis- istic ‘healing ceremonies’ for its potential cognitive benefits and
eases can have some similar epigenetic mechanisms influencing antidepressant properties. It has also been associated with severe
emotions. psychiatric sequelae.
Disclosure of interest.– The authors have not supplied a conflict of Aims.– To present a case report of a patient who was intoxicated
interest statement. with the psychoactive potion ayahuasca, followed by a literature
review on the hazards of intoxication with ayahuasca.
Methods.– An English language literature search was conducted
E-PP0101 using Pubmed and EMBASE searching for case reports and obser-
Prevalence of pregabalin abuse among vational studies reporting intoxication with the potion ayahuasca.
healthcare professionals in asser Results.– A 47-year-old female suffered a psychotic crisis after an
ayahuasca tea ceremony. Symptoms included delusional think-
province Saudi Arabia
ing, paranoid ideas, insomnia, emotional lability and hyperactivity
S. Alsubaie1* , A. Zarbah2 , A. Alqahtani Saeed3 , A. Abdullah3 , N.
with uncontrolled movements. These symptoms fluctuated and
Aledrees3 , W. Alshehri3 , F. Asiri3 , B. Zarbah4
1 Armed Forces Hospital- Southern Region, Psychiatry, Khamis persisted for over 4 weeks before she was taken into hospital.
There was no past history of any psychiatric problems. At the
Mushayt, Saudi Arabia; 2 Mental Health Hospital, Psychiatry, Abha,
psychiatric emergency department, she received an antipsychotic
Saudi Arabia; 3 King Khalid University, College of Medicine, Abha,
treatment with haloperidol and the psychotic symptoms gradually
Saudi Arabia; 4 King Khalid University, College of Pharmacy, Abha,
disappeared. Emotional lability including depressive symptoms
Saudi Arabia
* Corresponding author. remained for several months, possibly due to past traumatic expe-
riences she had not remembered until the moment of intoxication.
Background and aims.– Substance use disorders among healthcare Conclusions.– The use of ayahuasca can lead to long-term psy-
professionals (HCPs) are adversely affect the HCPs ability to per- chopathology. Subjects with a personal or family psychiatric
form their duties. The main objective of our study was to evaluate antecedents should avoid intake of this psychoactive potion.
the prevalence of pregabalin abuse among HCPs in Asser province Disclosure of interest.– The authors have not supplied a conflict of
of Saudi Arabia. We also correlate the results with different factors. interest statement.
Methods.– We conducted a descriptive cross-sectional study among
HCPs (n = 372) in three main hospitals in Asser region, using an
English online survey questionnaire. E-PP0103
Results.– Most of the participants were young (25.6 ± years), mar- Understanding public opinion to the
ried males with mean experience of 8.1 ± 10.6 years. About 43.4% introduction of minimum unit pricing
of the studied sample were physicians whereas paramedical staff, in Scotland: a qualitative study using
nurses and pharmacists constituted 29%, 17.7%, 9.7%, respectively.
twitter
The utilization rate was 11.6% of the sampled staff, and non-
L. Astill Wright* , S. Golder, A. Balkham, J. McCambridge
prescribed among 48.9% of pregabalin users. The prevalence of
University of York, Department of Health Sciences, York, United
pregabalin abuse among the studied sample was 0.06%. Almost,
Kingdom
61.9% of abusers were males, 52% (P = 0.03) of them were less * Corresponding author.
than 30-year-old, 57.1% (P = 0.05) paramedical staff. Approximately
42.9% of abusers use it for stress management with recorded sta- Background and aims.– On 1st May 2018 Minimum Unit Pricing
tistical significance (P = 0.005) and 52% abused more than one drug (MUP) of alcohol was introduced in Scotland. This study aimed to
at a time (P > 0.05). assess responses to the policy implementation in comments made
Conclusions.– The current research revealed that about 1 every on Twitter.
9 medical staff use pregabalin and nearly half of them use it Methods.– All tweets relating to MUP were captured during the
without medical prescription. Utilization rate was higher among two weeks after the introduction of the policy. These tweets were
young physicians and paramedical staff in special concern. Stress assessed using a mixture of human and machine coding for rele-
relief and euphoria sensation were the major factors behind abuse. vance, sentiment and source. A thematic analysis was conducted.
Despite limitations, this is the first study examined the prevalence Results.– 74,639 tweets were collected over 14 days. Study findings
of pregabalin abuse among HCPs. demonstrate that opinion on the introduction of MUP in Scotland
Disclosure of interest.– The authors have not supplied a conflict of is divided, as far as is discernible on twitter, with a slightly higher
interest statement. proportion of positive posts, particularly in Scotland itself. Fur-
thermore, 55% of positive tweets/retweets were originally made
by health or alcohol policy-related individuals or organisations.
E-PP0102 Thematic analysis of tweets showed some evidence of misunder-
Case-report of a ‘tea ceremony’ with standing around policy issues.
ayahuasca: an emotional rollercoaster Conclusions.– It is possible to appreciate the divided nature of public
M.H.L. Arts1* , S. Petrykiv2 , L. de Jonge3 opinion on the introduction of MUP in Scotland using twitter, the
1 Mental Health Care –Western North Brabant GGZ-WNB, nature of the sentiment around it, and key actors involved, and it
Department of Old Age Psychiatry and Neuropsychiatry, Halsteren, will be possible to later study how this changes when the policy
The Netherlands; 2 MUMC, Department of Clinical Pharmacy and becomes more established.
Pharmacology, Maastricht, The Netherlands; 3 Leonardo Scientific Disclosure of interest.– The authors have not supplied a conflict of
Research Institute, Department of Neuropsychiatry, Groningen, The interest statement.
Netherlands
Background and aims.– Ayahuasca, also called yagé, is a psy-

choactive potion of various plant infusions consisting of the
Banisteriopsis caapi vine, containing beta-carbolines, and the
E-PP0104 Background and aims.– In bipolar disorder, impairment in both cog-

Identification of cases of nitive functions and social functioning is seen even in remission.
We aimed to compare the cognitive functions of bipolar disorder
abuse/dependence by the
type 1 (BD-1) and healthy controls (HC) in the euthymic period
addictovigilance center of nancy and to investigate the relationship between cognitive functions and
university hospital (CEIP-A): a pilot functional areas in BD-1.
study in a psychiatric hospital Methods.– Consecutive outpatients with a diagnosis of euthymic
P. Barberot1* , V. Gibaja2 , D. Dobre3 , J. Tournebize2 , J.P. Kahn2,4,5 BD-1 (n = 75) and HC (n = 75) were included in the study. The sub-
1 CHRU de Nancy, Centre d’Evaluation et d’Information sur la jects were evaluated with Sociodemographic Data Form, Young
Pharmacodépendance-Addictovigilance CEIP-A, Nancy, France; 2 Mani Rating Scale (YMRS), Beck Depression Scale, Beck Anxiety
CHRU de Nancy, Centre d’Evaluation et d’Information sur la Scale, Montreal Cognitive Assessment Scale (MOCA) ve Bipolar Dis-
Pharmacodépendance-Addictovigilance CEIP-A - French order Functioning Questionnaire (BDFQ) and neuropsychometric
Addictovigilance Network FAN, Nancy, France; 3 Centre battery.
Psychothérapique de Nancy, Département de l’Information Médicale Results.– Statistically significant positive correlation was found
et Unité de Recherche et d’Investigation Clinique, Nancy, France; 4 between BDFQ total score and Auditory Verbal Learning Test (AVLT)
Centre Psychothérapique de Nancy, Pôle de Psychiatrie et de total recall score; and between BDFQ relations with friends score
Psychologie Clinique, Nancy, France; 5 Université de Lorraine, and AVLT immediate memory, learning scores. AVLT learning, high-
Professeur de Psychiatrie, Nancy, France est learning, self- recall, recognition scores and BDFQ daily activities
* Corresponding author. score were statistically significant positive correlated. Statistically
significant positive correlation was found between AVLT learning,
Background and aims.– France is the only European country self-recall, total recall scores and taking initiative score of the BDFQ
with a dedicated addictovigilance network (French Addictovig- (Table 1). Statistically significant negative correlation Wisconsin
ilance Network: FAN). Although mandatory, the reporting of Card Sorting Test (WCST) number of cards used for first categor-
abuse/dependence cases is insufficient. In an attempt to overcome ical completion and BDFQ total, social withdrawal, participation
this under-reporting, data from the Computerized Hospital Medical to social activities, daily activities scores (Table 2). There was a
Database (PMSI) is regularly used to identify cases. Since addictions statistically significant negative correlation between BDFQ total,
are frequently associated with psychiatric comorbidities, a pilot intellectual functioning, sexual functioning, taking initiative, occu-
study was conducted for the first time in a psychiatric hospital. pation scores and Trail Making Test-A scores (Table 3).
The objectives were 1: to identify the sociodemographic character- Conclusions.– Verbal memory, attention and executive functioning
istics and psychiatric diagnoses of patients abusing psychoactive disturbances in the euthymic patients followed by BD diagnosis
substances (PAS) and 2: to characterize those substances. may result in decreased functionality.
Methods.– A retrospective observational study was conducted Disclosure of interest.– The authors have not supplied a conflict of
between January and September 2017 at the Centre Psy- interest statement.
chothérapique de Nancy (CPN). Patients were identified in the
database by using the codes of the International Classification of
Diseases, tenth revision (ICD-10): F11 to F19, that characterize E-PP0106
mental and behavioral disorders associated with the use of PAS.
Benzodiazepines: why some
Cases presenting the criteria necessary for an addictovigilance noti-
fication were analyzed. detoxification procedures are
Results.– On an initial number of 252 cases, 82 cases of unsuccessful? rationale for
abuse/dependence (33%) were retained. The selected sample was serum-BZD monitoring
predominantly male (67%). Cannabis (29%), heroin (15%) and ben- A. Basińska-Szafrańska
zodiazepines (34%) were the most abused illicit PAS and drugs, Institute of Psychiatry and Neurology, Dept. of Prevention and
respectively. Overall, 64% of the subjects were diagnosed with “dis- Treatment of Addictions, Warsaw, Poland
orders related to the use of PAS” (F11-F19), 14% with “neurotic Background and aims.– Frequently detoxification from benzodi-
disorders” (F40-F48), 9% with “schizophrenia” (F20-F29) and 5% azepines (BZD) is ineffective. Moreover, there is no standardized
with “mood disorders” (F30-F39). procedure. This study was to identify what errors in common detox-
Conclusions.– This study identified a significant number of poten- ification procedures influence treatment failures.
tially reportable cases to the Addictovigilance Center and demon- Methods.– 420 in-patients converted to diazepam were detoxified
strated the interest of investigating cases of abuse/dependence in with concurrent serum-BZD monitoring (enzyme immunoassay).
a psychiatric hospital (1). Doses were reduced flexibly, driven by patients’ reports confronted
(1) Barberot et al. Thérapie.2018. https://doi.org/10.1016/j.therap. with laboratory results. Both the satiating serum-BZD and corre-
2018.10.002 sponding self-evaluation score (CIWA-B) were taken as baselines.
Disclosure of interest.– The authors have not supplied a conflict of Laboratory-confirmed elimination was followed by a 2-week-long
interest statement. observation.
Results.– After satiation, a fixed dose (“stabilization”) resulted
in over-accumulation (even 3-fold over the baseline), whereas
E-PP0105 an immediate dose reduction (16–33% daily) driven by labora-
The relationship between the tory feedback stopped the accumulation within 3–7 days. Facing
cognitive functions and areas of descending number of pills, some patients reported crises dur-
ing accumulation but rescinded after feedback information. The
functionality in bipolar disorder
serum-plateau initiated tapering driven by patient’s self-report,
type-1 but the overcumulation delayed reactions to reduced doses, which
Ö. Baş Uluyol1* , Ö. Şahmelikoğlu Onur2 misled clinical assessment. At zero-dose, high serum-BZD and
1 Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological negligible symptoms were typical. With lab-feedback minimized
Diseases Education and Research Hospital, 4. Psychiatric Clinic, accumulation, elimination still lasted 22 (sd14) days beyond drug
İstanbul, Turkey; 2 Bakirkoy Prof. Dr. Mazhar Osman Mental Health withdrawal. Elimination crises clustered at zero-level or later, pro-
and Neurological Diseases Education and Research Hospital, 3. longing medical assistance.
Psychiatric Clinic, İstanbul, Turkey
Conclusions.– Laboratory monitoring is crucial for successful detox. E-PP0108

Preventing over-accumulation starts the detox earlier and from Sermonide and the Z-drugs. A method
lower levels, increases reliability of patients’ reports, narrows the
driven by quantitative
elimination window (and protracted symptoms) after the nominal
withdrawal. Only adaptation at confirmed zero-serum level con-
serum benzodiazepine monitoring in
cludes the detox, not optimistic patients’ reports at withdrawal. treatment of non-BZD hypnotics
The laboratory-driven compression of initial stages enables long- dependent patients
enough assistance at the low-concentration phase. Prematurely A. Basińska-Szafrańska
concluded detox may cause a relapse by putting patients into Institute of Psychiatry and Neurology, Dept. of Prophylaxis and
inevitable crises outside the detox facility. Treatment of Addictions, Warsaw, Poland
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– SERMONIDE is a customized detoxification
interest statement. method driven by quantitative serum-benzodiazepine (BZD) mon-
itoring. Due to ability to cope with the widespread differences
in the BZD-metabolism rate, it provides a reliable detox proce-
E-PP0107 dure. Currently the method has been tested in treatment of Z-drug
Detoxification of dependency.
benzodiazepine-dependent patients, Methods.– Z-drug dependent patients (n = 75) were detoxified using
SERMONIDE. The results were compared with those from analo-
driven by serum-BZD concentration
gously treated 329 BZD-dependent patients. SERMONIDE consisted
analysis. presentation of the of 4 lab-defined stages. After switching to diazepam (1–2 days, sub-
sermonide (serum-BZD monitored stitution stage), the serum-BZD level at patient-reported satiation
detoxification) method and the related self-evaluation score (CIWA-B) were taken as base-
A. Basińska-Szafrańska lines. To counteract further serum-BZD accumulation, subsequent
Institute of Psychiatry and Neurology, Dept. of Prevention and doses were aggressively reduced, as driven by daily laboratory feed-
Treatment of Addictions, Warsaw, Poland back, until serum-BZD plateau was achieved (accumulation-control
Background and aims.– Customized detoxification, driven not only stage). Further tapering rate (elimination stage) positively slowed
by patient’s reports but quantitative serum-benzodiazepine (BZD) down, as driven by patients’ report, with serum-BZD check every
monitoring, may create a new efficient and reliable standard 3–7 days, until confirmed zero serum level. Medical assistance con-
procedure. This communication presents SERMONIDE (Serum- tinued (adaptation stage) until stabilization near patient’s CIWA-B
BZD Monitored Detoxification), an optimized method developed baseline.
through 420 courses of individual detoxifications with monitored Results.– The Z-drug patients needed higher satiating doses than
evolution (discussed elsewhere) of serum-BZD concentration. patients converted from the BZDs (median 31 vs 20 mg). The Z-
Methods.– SERMONIDE consists of 4 lab-defined stages: substitu- drug patients reported first withdrawal crises in markedly earlier
tion, accumulation-control, elimination and observation. For 1–2 stages of elimination (on med. 9th vs. 15th day) and completed the
days repeated doses of diazepam are administered until reported serum-BZD elimination after (median) 35 vs. 30 days. Despite those
satiation state (substitution stage). The serum-BZD level at satiation differences (analyzed within the presentation), the dropouts rates
(enzyme immunoassay) and related self-evaluation score (CIWA-B) were low (4 (5,3%) vs. 28 (8,5%).
are taken as baselines. To counteract further serum-BZD accumu- Conclusions.– In the Z-drug group SERMONIDE proved as highly
lation, subsequent doses are aggressively reduced (16–33% daily) effective as in the BZD group, resulting in a very high ratio of
driven by laboratory feedback, until serum-BZD plateau is achieved completed detoxifications. SERMONIDE might provide a universal
(accumulation-control stage). With the elimination stage, further detoxification treatment from many CNS-depressants.
tapering rate switches into driven by patients’ report and usually Disclosure of interest.– The authors have not supplied a conflict of
slows down, with serum-BZD check every 3–7 days. Serum-BZD interest statement.
monitoring lasts beyond drug withdrawal, until confirmed zero
serum level. After zero, medical assistance is continued until stabi-
lization near patient’s CIWA-B baseline. E-PP0109
Results.– Introduction of SERMONIDE increased treatment comple- Efficacy of celecoxib adjunct
tion rate from 46% to 92%. The substitution stage is well tolerated. treatment on bipolar disorder:
The immediate laboratory-driven dose reduction terminates the
systematic review and meta-analysis
accumulation stage within 3–7 days. Typically, elimination crises
D. Bavaresco1* , T. Colonetti1 , A. Jose Grande2 , F. Colom3 , S.
(mild-moderate as ameliorated by non-BZD medication support)
Valvassori4 , J. Quevedo4 , M.I.D. Rosa1
clustered at BZD-level approaching zero, 22 (sd14) days after drug 1 UNESC, Translational Biomedicine Laboratory, Criciúma, Brazil; 2
withdrawal. Clinical adaptation is reached 11 (sd16) days later.
Universidade Estadual de Mato Grosso do Sul, Laboratório de
Conclusions.– Laboratory-driven compressed substitution and
Evidências em Saúde, Dourados, Brazil; 3 IMIM-Hospital del
accumulation stages save time for longer medical assistance, nec-
Mar-CIBERSAM-, Mental Health Group, Barcelona-Catalonia, Spain; 4
essary at low-concentration stages (down to zero) and later, weeks
UNESC, Translational Psychiatry Laboratory, Criciúma, Brazil
after the nominal withdrawal. This prevents drop-outs and early * Corresponding author.
relapses.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– Bipolar Disorder (BD) is a psychiatric disor-
interest statement. der characterized by mood disturbances. The pathophysiology of
BD is still poorly precise. In the last years, the study involving the
role of inflammation in BD. The aim was performed a systematic
review and meta-analysis to evaluated the potential effect of the
cyclo-oxygenases (Cox)-2 inhibitor Celecoxib adjunct treatment in
BD, through of randomized controlled trials (RCT).
Methods.– A search of the electronic databases was proceeded,
on MEDLINE, EMBASE, Scopus, Cochrane Central Register of Con-
trolled Trials (CENTRAL), Biomed Central, Web of Science, IBECS,
LILACS, PsycINFO, Congress Abstracts, and Grey literature (Google
Scholar and the British Library) for studies published from January Background and aims.– Psychoeducational family intervention (PFI)
1990 to February 2018. A search strategy was developed using the is effective in improving the levels of family burden and patients’
terms: “Bipolar disorder” or “Bipolar mania” or “Bipolar depres- personal functioning in schizophrenia and bipolar disorders (BDs).
sion” or “Bipolar mixed” or “Bipolar euthymic” and “Celecoxib” Less is known about the impact of PFI on relatives’ coping strategies.
or “Cyclooxygenase-2 inhibitors” or “Cox-2 inhibitors” as text Aims.– To evaluate the efficacy of PFI improves problem-oriented
words and Medical Subject Headings (i.e., MeSH and EMTREE) coping strategies in relatives of patients with Bipolar I Disorder
and searched. The therapeutic effects of adjunctive treatment with (BD-I) compared to the treatment as usual (TAU) group.
Celecoxib were analyzed. The meta-analysis was performed includ- Methods.– A multicenter, controlled, outpatient trial coordinated by
ing the results of the Young Mania Rating Scale (YMRS) at the end the University of Campania “Luigi Vanvitelli” has been conducted
of RCT. in patients with BD-I and their relatives recruited in 11 randomly
Results.– Three primary studies were included in the systematic selected Italian community mental health centers.
review, with a total of 121 patients. In the meta-analysis showed Results.– The sample was constituted of 123 patients and 139
a significant effect in the YMRS scores from patients with BD who relatives. At the end of the intervention, relatives receiving PFI
used Celecoxib adjuvant treatment in comparison placebo. reported a higher endorsement of adaptive coping strategies, such
Conclusions.– The systematic review suggests that adjuvant treat- as “maintenance of social interests” (p < 0.05), “positive communi-
ment with Celecoxib improves the response of major treatments in cation with the patient” (p < 0.001), and “searching for information”
patients with BD when compared with adjuvant placebo treatment. (OR = 0.443, CI = 0.12–0.76; p = 0.007). Moreover, treated relatives
Disclosure of interest.– The authors have not supplied a conflict of less frequently reported to adopt “resignation” (p < 0.05) and “coer-
interest statement. cion” (p < 0.05) strategies, compared to the TAU group.
Conclusions.– PFI is effective in improving coping strategies of rela-
tives of BD-I patients, but further studies are needed for evaluating
E-PP0110 the long-term benefits of this intervention.
Bipolar disorder and suicide: risk Disclosure of interest.– The authors have not supplied a conflict of
factors to know in multiprofessional interest statement.
practice in health
R. Boaes
E-PP0112
Federal University of Rio de Janeiro, Health Sciences Centre \ Institute
of Gynecology, Rio de Janeiro, Brazil
Are neurocognitive functions altered
Background and aims.– This study analyzes the relationship in descendants of parents with bipolar
between suicide and bipolar disorder. disorder?
Methods.– Literature review on bipolar disorder, suicidal behavior G. Boukhari* , L. Mnif, M. Chakroun, S. Derouiche, W. Abdelghaffar,
and suicidal ideation. W. Melki
Results.– Suicidal behavior includes three types of self-destructive Razi Hospital, Sfar Department, Tunis, Tunisia
acts: consumed suicide, attempted suicide and non-suicidal self- * Corresponding author.
harm. Suicidal ideation includes suicidal thoughts and plans.

Bipolar disorder is strongly associated with suicidal ideation and Background and aims.– Descendants at familial high risk of bipolar
attempted suicide. Studies indicate: 14–59% of patients have suici- disorder may exhibit neurocognitive impairments. Large studies of
dal ideation and 25–56% have at least one suicide attempt during neurocognition in descendants at familial high risk are important
life. Approximately 15% to 19% of patients with bipolar disorder die to differentiate the pathophysiology and developmental trajectory
from suicide. In patients with bipolar disorder, multiple drug use, of this group.
borderline personality comorbidity-related impulsivity, and polar- Methods.– Electronic search was carried out in September 2018.
ity of the first episode of mood (depression or manic / hypomanic) PubMed database has been used to find studies to introduce in this
are markers of suicidal behavior. Depressed patients have a lifelong review. Keywords used in the search process were represented by
history of more suicide attempts. Manic / hypomanic patients were bipolar AND (young relatives OR offspring OR children OR descen-
more likely to attempt violent suicide. dants). Ultimately, ten articles were included following abstract
Conclusions.– Bipolar disorder is the psychiatric illness with the review.
highest risk of suicide attempts and consummation of suicide. It Results.– Some studies showed worse performance in processing
is related to the use of combination therapy, impulsivity and type speed and immediate recall of visual memory relative to descen-
of first episode. Suicide traitors (non-violent and violent) belong dants of parents with no history of psychotic disorder, as well
to different phenotypic groups. Health professionals need to know as reduced sensitivity during attention and executive funtions. In
the risk factors for suicidal behavior, in order to qualify the health other surveys, descendants of parents with bipolar disorder showed
care offered and prevent such behavior. selective deficits in spatial memory. Another survey suggests that
Disclosure of interest.– The authors have not supplied a conflict of descendants of bipolar parents have lower IQ scores compared to
interest statement. offspring of healthy controls.
On the other hand, other studies reported spared neurocogntive
functions with regard to intelligence, executive functions, verbal
E-PP0111 learning and memory, and attention. Neurocognitive deficits were
Psychoeducational family not necessarily concurrent with significantly lower intelligence.
Conclusions.– The evidence concerning neurocognitive functioning
intervention: is it effective in in descendants of parents with bipolar disorder is scarce and con-
improving relatives’ coping tradictory. Several studies observed deficits in processing speed,
strategies? attention, visual memory, executive functions, and intelligence,
G. Borriello* , G. Sampogna, V. Giallonardo, V. Del Vecchio, M. whereas other reported spared neurocogntive functions. Therefore,
Luciano, M. Savorani, B. Pocai, C. Palummo, A. Fiorillo there is a need to further explore this track, using larger samples,
University of Campania “L. Vanvitelli”, Department od Psychiatry, to clarify the above-mentioned contradictions.
Naples, Italy Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
E-PP0113 sodium valproate. As for the DPP, it was associated with female
Anxiety disorder and bipolar disorder: gender (p = 0,017), inaugural depressive episode (p < 0,001), greater
frequency, risk factors and impact in a number of mixed episodes (p = 0;003), rapid cycle (p < 0,001), anx-
iety disorder co-morbidities (p < 0,001), family history of mood
Tunisian population disorder, higher suicidal risk (p = 0,001), as well as the prescription
S. Smaoui, L. Mnif, G. Boukhari* , S. Derouiche, W. Abdelghaffar, W.
of antidepressants, lithium and lamotrigine.
Melki
Conclusions.– The concept of predominant polarity may have clin-
Razi Hospital, Psychiatry D Departement, la Manouba, Tunisia
ical and therapeutic relevance. His consideration as a specifier in
bipolar disorder remains debatable.
Background and aims.– Bipolar disorders (BD) have a high rate of Disclosure of interest.– The authors have not supplied a conflict of
comorbidity with a multitude of psychiatric disorders and medi- interest statement.
cal conditions. Among all the potential comorbidities, co-existing
anxiety disorders (AD) stand out due to their high prevalence.
E-PP0115
Our study aimed to assess the frequency and impact of anxiety
disorders on illness severity and complications. The attentional boost effect does not
Methods.– It is a retrospective, descriptive and analytical study increase long-term memory in
in the form of an investigation in which a form was completed euthymic bipolar patients
by the examiner based on the data collected from the patient, G. Bechi Gabrielli1 , C. Rossi-Arnaud1 , P. Spataro1 , G. Angeletti2 , G.
the examination of the medical file as well as results of the Sani2 , V. Cestari1*
Mini International Neuropsychiatric Interview (MINI) question- 1 Sapienza University, Psychology, Roma, Italy; 2 Sapienza University,
naire in its Arabic version, covering 188 patients followed for type UOC Psichiatria S. Andrea, Roma, Italy
I BD. * Corresponding author.
Results.– The average age in our sample was 37,29 years old. The
sex ratio was (♂ / ♀) = 0,84. In our sample, 49,5% had at least 1 Background and aims.– When stimuli are encoded with to-be-
lifetime anxiety disorder. The three most frequently observed anx- responded targets they are recognized more accurately than when
iety disorders were social phobia (26,6%), panic disorder (24,5%), encoded with to-be-ignored distractors. This attentional boost
and generalized anxiety disorder (20,2%). Bipolar patients with an effect (ABE) is robust in young adults, but eliminated in healthy
early onset of illness had more comorbidity with anxiety disorder older adults and in clinical populations. Bipolar (BP) disorder is
(p = 0,03), likewise patients with depressive onset. Anxiety disor- characterized by attention deficits, even in the euthymic phase of
ders were detected more frequently in patients with predominant the disease: it is thus worth investigating whether an ABE occurs
depressive polarity than patients with predominant manic polarity in BP patients.
(p < 0,001). Comorbidity with anxiety disorders was correlated with Methods.– 28 euthymic BP outpatients and 30 healthy controls (HC)
lifetime history of suicide attempt (p = 0,001), median/high suicidal were recruited. To investigate also age effects, we divided both sam-
risk (p < 0,001), rapid cycle (0,009) and prescription of antidepres- ples into two sub-groups: young (18 to 35 years) and adult (36 to 59
sants (p < 0,001). years). Participants had to encode a sequence of pictures while per-
Conclusions.– Patients with bipolar disorders often have comorbid forming a detection task: when a red target square appeared they
anxiety disorders, particularly patients with predominant depres- had to press the spacebar. After a 15-min interval, their recognition
sive polarity, early onset of illness and depressive onset. of pictures was tested.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Performance in the detection task was worse in BP patients
interest statement. than in HC, in both age groups. More importantly, neither young nor
adult BP showed an ABE while a robust ABE was found in young HC
but not in adult HC.
E-PP0114 Conclusions.– These data support the hypothesis that bipolar disor-
Predominant polarity in bipolar der is characterized by attentional deficits, even in the remission
phase. We suggest that the increase in the attentional demands of
disorder in a Tunisian population
the detection task subtracted attentional resources from the encod-
S. Smaoui, L. Mnif, G. Boukhari* , S. Derouiche, W. Abdelghaffar, W.
ing of target-associated stimuli in patients, eliminating the ABE. The
Melki
lack of ABE in adult control participants above 35 is in line with the
Razi Hospital, Psychiatry D Departement, la Manouba, Tunisia
hypothesis of an age-related decline in the facilitatory mechanisms
Background and aims.– The study of predominant polarity (PP) in
underlying the ABE.
bipolar disorder has been developed in recent years.
Our study aimed to examine PP in a Tunisian population.
interest statement.
Methods.– This is a retrospective, descriptive and analytical study.
A total of 188 patients followed for BD type I were recruited.
The definition of the predominant polarity retained was the pres-
E-PP0116
ence of at least two thirds of episodes in the whole life on the same
pole. We compared the predominant depressive polarity (DPP) Catatonia in psychotic
and the predominant maniac polarity (MPP) on a broad range of depression:diagnostic and therapeutic
parameters, including sociodemographic, clinical characteristics, challenges
co-morbidities and treatments. R. Chacko
Results.– The average age in our population was 37,29 years old. Methodist Neurological Institute, Psychiatry, Houston, USA
The sex ratio (♂ / ♀) = 0,84. In our sample, 64,1% of the subjects ful- Background and aims.– Catatonia is a Neuropsychiatric syndrome
filled the criteria of MPP, and 33,9% of them fulfilled the criteria with distinct psychomotor symptoms.
of DPP. MPP was associated with male gender (p = 0,017), manic Catatonia may mimic a variety of psychiatric and medical condi-
inaugural episode (p < 0,001), inaugural episode with psychotic tions.
features (p < 0,001), higher number of episodes with psychotic fea- Methods.– Catatonia, a neuropsychiatric syndrome may present
tures (p < 0,001), addictive comorbidities, earlier suicide attempt with mutism,immobility,stupor and frequently leads to life threat-
(p = 0,021), earlier hospitalization (0,043), greater number of hospi- ening medical complications of dehydration and malnutrition.
talizations (0,041) and prescription of neuroleptics (p < 0,001) and
NMDAR encephalitis,has more recently been implicated in several Conclusions.– The association between elevated CRP levels and BD
cases often presenting with bizarre behavior,altered mental status might be caused by reverse causality or mediated by confound-
and Catatonia. ing factors. Further studies are needed to clarify the role of CRP in
Comprehensive laborotary testing including lumbar puncture for pathophysiology of BD.
spinal fluid assessment of NMDAR antibodies and PET Brain Imag- Disclosure of interest.– The authors have not supplied a conflict of
ing which often reveal typical patterns of perfusion abnormalities interest statement.
often results in a probable diagnosis and treatment usually ensues
with Intravenous Corticosteroids,IVIG and Plasmapharesis.
The Case presented will illustrate a Case where the diagnosis of E-PP0118
Catatonia with Psychotic Depression was misidentified because of Behind the clinical scales:
evaluation findings which led to a diagnosis of autoimmune limbic neurocognition and social cognition
encephalitis,thus delaying appropriate treatement in a Psychiatric
in bipolar mania
setting with Electroconvulsive therapy.
E. Ciftci
Results.– Patient received a Course of ECT after a Diagnostic test
Cizre State Hospital, Psychiatry, Şırnak, Turkey
with Intravenous Lorazepam which immediately reversed the
Background and aims.– Patients with bipolar disorders exhibit
symptoms temporarily allowing for a Final Diagnosis of Catatonia
deficits in social and neurocognition even during remission and
secondary to Psychotic depression and appropriate treatment with
interfere with everyday life. This study aims to find association of
a course of Electroconvulsive therapy with complete remission of
executive functions and emotion and social cognition with clinical
symptoms after 8 treatments.
symptomatology (mood, activity and speech) and global function-
1 year follow up has confirmed the diagnosis because the patient
ing.
has maintained remission with Maintenance ECT, antidepressant
Methods.– Thirty-five male and sixteen female patients who were
therapy.
diagnosed as BD type I, manic episode according to DSM-5 in
Conclusions.– Catatonia is often a Neuropsychiatric syndrome
the mental health service were included. All participants received
which can mimic many conditions
a comprehensive neuropsychological assessment and ratings of
Most recently,the interest in Auto immune Limbic Encephalitis has
depressive Montgomery-Asberg Depression Rating Scale (MADRS)
often led to false positive or ambiguous test results and thus delay
and manic [Young Mania Rating Scale (YMRS)] symptoms at
in appropriate psychiatric interventions such as ECT.
baseline and follow-up. Symptoms were examined in relation to
neurocognitive performance.
interest statement.
Results.– In the first week of bipolar manic episode, YMRS scores
of bipolar mania patients, elevated mood (item 1), increased motor
E-PP0117 activity-energy (item 2), speech (rate and amount) (item 6) and
total scores were all significantly correlated with SSRT, spearman’s
Is C-reactive protein level a causal rho value (r) as were 0,583, 0,504, 0,338 and 0,505 respectively.
factor in risk of bipolar disorder? a Correlation of item 1 with deliberation time (r = 0,3) and rate of
mendelian randomisation study angry emotion recognition were found (r = -0,34). Item 2 and total
H.H. Chang1* , L.Y. Tang2 , P.S. Chen3 score were positively correlated with total rate of bet (r = 0,38 and
1 National Cheng Kung University, School of Pharmacy & Institute of r = 0,35). General assesment of functioning score was correlated
Clinical Pharmacy and Pharmaceutical Sciences, Tainan, Taiwan with deliberation time (r = -0,371) and total rate of bet (r = -0,443).
R.O.C.; 2 National Cheng Kung University, Institute of Clinical Conclusions.– Bipolar disorder mania clinical symptomatology was
Pharmacy and Pharmaceutical Sciences, Tainan, Taiwan R.O.C.; 3 associated with neurocognition and social cognition. Cognitive and
National Cheng Kung University, Department of Psychiatry, Tainan, emotion recognition dysfunction relation to other key symptom
Taiwan R.O.C. dimensions and to diagnostic categories and general functioning
* Corresponding author. will help clarify shared neural correlates and guide efforts toward
personalized treatment approaches.
Background and aims.– Patients with bipolar disorder (BD) showed Disclosure of interest.– The authors have not supplied a conflict of
more inflamed condition, which is at high risk of metabolic distur- interest statement.
bance and cognitive impairment. However, whether elevated CRP
level is causally associated with BD is not still established because
of study design, mood state and use of medications. In the study, E-PP0119
we aimed to examine whether CRP is a causal factor in risk of BD Impaired glucose metabolism in
by conducting a Mendelian randomization analysis in depressed
drug-naive BD patients.
bipolar disorder and response to
Methods.– We recruited 112 community-dwelling controls and 191 treatment: a prospective study
BD patients. The BD patients were all in a major depressive status, G. D’agostino1* , L. Steardo Junior1 , A. Monteleone Maria1 , V.
with 17-item HDRS scores > 15. The CRP level and the SNPs of CRp Buonomenna Maria1 , M. Fabrazzo1 , P. Monteleone2
1 University of Campania “Luigi Vanvitelli”, Department of Psychiatry,
genotype were examined to conduct a Mendelian randomization
analysis. Napoli, Italy; 2 University of Salerno “Scuola Medica Salernitana”,
Results.– The demographic characteristics did not differ signif- Department of Medicine- Surgery and Dentistry, Salerno, Italy
icantly between the controls and BD patients. The genotype
frequencies of the CRp SNPs in the BD patients and controls were
Background and aims.– Bipolar disorder (BD) is associated with sig-
not different, while the CRP levels were significantly higher in
nificant physical comorbidity, including type 2 diabetes mellitus
the BD patients than that in the controls (1818.51 ± 1732.61 and
(T2D) and insulin resistance (IR).
145.63 ± 199.63 ng/ml, respectively, p < .001). Moreover, we found
Our study aimed to investigate the one-year course of BD patients
that SNPs rs1205 and rs2794520 showed significant impacts on
with T2D or IR compared to euglycemic patients.
plasma CRP levels with a beta coefficient 0.522 (p = .028) and 0.532
Methods.– We recruited 92 BD patients (33 with T2D, 18 with IR
(p = .027), respectively. The overall estimates of Mendelian random-
and 41 with no abnormality of glucose metabolism). They were
ization indicated that the causal effect of the plasma CRP levels on
treated with different mood stabilizers and assessed prospectives
the risk of BD was not statistically significant.
on different psychometric scales and metabolic variables.
Results.– At one year assessment, we found that compared to Disclosure of interest.– The authors have not supplied a conflict of
euglycemic, patients with BD and comorbid T2D or IR, had a interest statement.
significant increase in body mass index (BMI) (0,00000376), hyper-
triglyceridemia (0,026), and significantly worse scores in Hamilton
Anxiety Scales and Montgomery-Asberg Depression Rating Scale. E-PP0121
However, BD patients with IR and T2D hadn’t higher odds of chronic History of childhood trauma and
course of the BD or higher odds of episodes compared to the eug- psychosis in bipolar disorder:
lycemic ones.
moderation by psychiatric family
Conclusions.– Present findings confirm that BD with comorbid T2D
or IR is associated with a worst metabolic course and more severe history
psychopathology, but contrary to previous literature findings, it had P. Ferentinos* , E. Porichi, K. Dafnas, F. Christidi, I. Troumousi, A.
not a worse clinical course. Douzenis
Disclosure of interest.– The authors have not supplied a conflict of National and Kapodistrian University of Athens- Medical School, 2nd
interest statement. Department of Psychiatry, Athens, Greece
Background and aims.– History of childhood trauma (HCT) is asso-

E-PP0120
ciated with higher clinical severity and worse outcomes/ prognosis
N-methyl-D-aspartate receptor of bipolar disorder (BD). Previous findings on the association of HCT
(NMDAR) and glutamic acid and lifetime psychosis in BD have been inconsistent. We aimed
decarboxylase (GAD) antibodies and to investigate the yet unexplored moderating role of psychiatric
peripheral insulin-like growth factor family history (FH) in the association between HCT and lifetime
psychosis in BD.
(IGF) in mania, depression and
Methods.– We administered to 99 euthymic BD-I patients,
remission during long-term followed-up in a bipolar clinic, the Childhood Abuse and Trauma
lithium-treatment Questionnaire (CATS), measuring four dimensions of HCT: neglect
E. Ferensztajn-Rochowiak1* , M. Kaczmarek2 , M. Wójcicka3 , E. (NEG), sexual abuse (SA), physical abuse/ punishment (PUN) and
Kaufman-Szukalska3 , S. Dziuda4 , A. Remlinger-Molenda1 , A. emotional abuse (EA). FH in first-degree relatives of schizophre-
Szeliga-Neymann1 , J. Losy3 , J.K. Rybakowski1 nia (FH-SCZ) and affective disorders (FH-AFF), i.e. BD (FH-BD) and
1 Poznan University of Medical Sciences- Poland, Department of Adult
major depression (FH-MDD), was extracted with the Family Inter-
Psychiatry, Poznań, Poland; 2 Poznan University of Medical Sciences- view for Genetic Studies. We fitted multiple regression models
Poland, Department of Clinical Immunology, Poznań, Poland; 3 predicting CATS total score and its four dimensions, including inter-
Poznan University of Medical Sciences- Poland, Department of actions between FH and lifetime psychosis as well as age and gender
Clinical Neuroimmunology, Poznań, Poland; 4 Poznan University of as covariates.
Medical Sciences- Poland, Department of Psychiatric Genetics- Results.– Overall, HCT was not associated with lifetime psychosis
Department of Psychiatry, Poznań, Poland or FH. We found a negative interaction of FH-BD with lifetime
psychosis for CATS total score (p = 0.002), NEG (p = 0.002) and EA
(p = 0.001); positive FH-BD patients with psychosis had lower HCT
Background and aims.– Bipolar disorder (BD) is related to scores than those without psychosis. We also recorded a negative
disturbances of glutamatergic system. The glutamate-related triple interaction between FH-AFF, FH-SCZ and lifetime psychosis
antineuronal antibodies against NMDAR and GAD can cause for CATS total score (p = 0.039), NEG (p = 0.045), PUN (p = 0.022) and
autoimmune limbic encephalitis and occur three times more fre- EA (p = 0.022).
quently in patients with BD [1,2]. The IGF-1 levels are increased Conclusions.– HCT and psychiatric family history have competing
in 1/3 bipolar subjects [3], with possible protective effect against effects on psychosis in BD. This might explain literature inconsis-
NMDA-induced excitotoxicity. Long-term lithium prophylaxis in tencies in associations between HCT and psychosis in BD.
BD may cause remission through normalization of glutamatergic Disclosure of interest.– The authors have not supplied a conflict of
system pathology. The aim of the study was to assess serum levels interest statement.
of anti-NMDAR and anti-GAD antibodies, and IGF-1 in BD patients
during manic and depressive episodes and in immediate remission
after episodes, compared with euthymic lithium-treated patients. E-PP0122
Methods.– Serum levels of anti-NMDAR, and anti-GAD 450/620
Interpersonal social rhythm therapy
antibodies, and IGF-1, were measured using ELISA in 19 manic and
17 depressed patients both in the acute episode and remission after (IPSRT) in group or individual format
the episode. The control group included 18 euthymic BD patients in bipolar disorder: a randomized
receiving lithium for 9–44 years (mean 22 ± 11 years), in which a controlled trial
single measurement was performed. G. Fico* , L.J. Steardo, V. Caivano, F. Zinno, M. Raia, G. Sampogna, M.
Results.– Anti-NMDAR levels were higher in mania than in lithium- Luciano, A. Fiorillo
treated patients (p = 0.006). Anti-GAD 450/620 levels were higher University of Campania “Luigi Vanvitelli”, Psychiatry, Naples, Italy
in mania and depression, compared with remission after respec- * Corresponding author.
tive episodes (p = 0.034 and p = 0.005) and lithium-treated patients

(p = 0.033 and p = 0.017). IGF-1 levels were higher in mania Background and aims.– Interpersonal and Social Rhythm Therapy
(p = 0.033) and remission after mania (p = 0.019), than in lithium- (IPSRT) is an evidence-based psychosocial intervention proven to
treated patients. be effective in adults with bipolar disorder (BD). The main goals
Conclusions.– Increased levels of anti-NMDAR and anti-GAD anti- of this therapy are to: regularize daily rhythms, promote mood
bodies may contribute to the glutamate-related pathology of BD. stability, manage interpersonal relationships, learn stress-coping
Increased levels of IGF-1 may comprise a compensatory mechanism strategies. IPSRT has been proposed in group or individual format,
against excitotoxicity. Long-term lithium prophylaxis may cause however, the comparative efficacy of these two formats has been
normalization of anti-NMDAR, anti-GAD antibodies and IGF-1 lev- examined rarely. Our aim is to evaluate the efficacy of group IPSRT
els. (IPSRT-G) in terms of reduction of the stress measured by the saliva
Cortisol Awakening Response (CAR) compared to individual IPSRT E-Poster Presentation: Child and Adolescent
setting (IPSRT-I). Psychiatry - Part I
Methods.– A randomized controlled trial is been carried out with all
patients affected by BD attending the outpatient unit of affective
disorders at the University of Campania “Luigi Vanvitelli”. Patients
will be randomly allocated to a group receiving 60-minute of IPSRT- E-PP0124
G every week for 8 weeks, or to a group receiving 60-minutes Safety and efficacy of lithium in
of IPSRT-I every week for 8 weeks. Patients will fill in: Clinical children and adolescents
Global Impression for BD (CGI-BD), Seasonal Pattern Assessment A. Amerio1* , S.N. Ghaemi2
Questionnaire (SPAQ), Morningness-Eveningness Questionnaire 1 Inpatient Mental Haelth Service- SS. Antonio e Biagio e Cesare
(MEQ-SA), Global Assessment of Functioning (GAF), Manchester Arrigo Hospital, Department of Mental Health, Alessandria, Italy; 2
Short Assessment of Quality of Life (MANSA), at baseline and at Tufts Medical Center, Mood Disorders Program, Boston, USA
3, 6 and 12 months post-randomization. Saliva samples at awaken- * Corresponding author.
ing and after 15, 30, 60 minutes after awakening will be collected
Background and aims.–
at each time.
Introduction.– Many clinicians are reluctant to use traditional
Results.– Patients receiving IPSRT-G will have a reduced cortisol
mood-stabilizing agents, especially lithium, in children and ado-
levels in comparison to those receiving IPSRT-I.
lescents. This review examined the evidence for lithium’s safety
Conclusions.– We expect that (IPSRT-G) will be effective in reduc-
and efficacy in this population.
ing relapses, stress, improving quality of life and reducing the cost
Objectives.– A systematic review was conducted on the use of
associated with the individual format.
lithium in children and adolescents with bipolar disorder (BD).
Methods.– Methods: Relevant papers published through June 30th
interest statement.
2018 were identified searching the electronic databases MEDLINE,
Embase, PsycINFO and the Cochrane Library. We combined the
E-PP0123 search strategy of free text terms and exploded MESH headings
for the topic of treatment with lithium in children and adolescents.
Lithium therapy and The strategy was first developed in MEDLINE and then adapted for
hyperparathyroidism: the importance use in the other databases (figure 1).
of calcium metabolism assessment
L. Steardo jr, V. Caivano, F. Zinno, A. Vece, S. Agnese, G. Fico* , M.
Luciano, A. Fiorillo
University of Campania “Luigi Vanvitelli”, Psychiatry, Naples, Italy
Background and aims.– According to international guidelines,

lithium is the gold standard for the treatment of patients with
bipolar disorder. Its use is associated with several side effects,
particularly thyroid and renal dysfunctions. Therefore, a careful
assessment of renal and thyroid functions is recommended before
and during lithium therapy. However, despite several evidences
show that lithium may induce hyperparathyroidism, the evaluation
of parathyroid functioning and calcium metabolism is not currently
recommended. Our aim is to evaluate the impact of lithium on
calcium metabolism and levels of parathormone (PTH).
Methods.– All patients with bipolar I or II disorders attending the
mental health department of the University of Campania “Luigi
Figure 1. Flow diagram of selected articles.
Vanvitelli” were enrolled. Socio-demographic data, as well as levels
of serum calcium, PTH and vitamin D were collected. Results.– 30 articles met inclusion criteria, including 12 randomized
Results.– The sample consisted of 67 patients, mainly women (55%), controlled trials (RCTs) (Fig.1). Findings from RCTs demonstrate
with a mean age of 49 (SD ± 12) years. 43% of patients received efficacy for acute mania in up to 50% of patients, and evidence
lithium treatment. No significant differences were found between of long-term maintenance efficacy. Lithium was generally safe, at
the two groups regarding socio-demographic and clinical charac- least in the short term, with most common side effects being gas-
teristics. Instead, patients treated with lithium (p < 0.001) reported trointestinal, polyuria, or headache. Only a minority of patients
higher levels of PTH compared to the other group, while no signif- experienced hypothyroidism. No cases of acute kidney injury or
icant differences were found in the levels of calcium and vitamin chronic kidney disease were reported.
D. Conclusions.– Though the available literature is mostly short-term,
Conclusions.– The results of our study highlight the importance there is evidence that lithium monotherapy is reasonably safe and
to evaluate calcium metabolism and PTH before starting lithium effective in children and adolescents, specifically for acute mania
treatment and during follow-up. Further evidences are needed in and for prevention of mood episodes.
order to identify the sociodemographic and clinical predictors for Disclosure of interest.– The authors have not supplied a conflict of
alterations of calcium metabolism. interest statement.
interest statement.
E-PP0125 E-PP0126
Psychotherapy for borderline Sex clinical and cognitive differences
personality disorder in adolescents: over an ADHD population using
systematic review and meta-analysis screening tests
A. Bahji* , J. Wong, S. Khalid-Khan A. Ballesteros Prados1* , Á.S. Rosero Enríquez2 , F. Inchausti
Queen’s University, Psychiatry, Kingston, Canada Gömez3 , A. Petcu4
* Corresponding author. 1 Osasunbidea, Psychiatry, Estella, Spain; 2 Osasunbidea, Psychiatry,
Pamplona, Spain; 3 Rioja Salud, Psychiatry, Logroño, Spain; 4 Pennine

Background and aims.– Borderline personality disorder (BPD) is a Hospital NHS Trust, Psychiatry, Preston, United Kingdom
debilitating condition, but several psychotherapies are considered * Corresponding author.
effective in children and adolescents. To date, however, their effi-
cacy has not been systematically reviewed or synthesized. Here, Background and aims.– ADHD scales have been used to monitor
the authors conduct a systematic review and meta-analysis of ran- severity of attention deficit hyperactivity disorder (ADHD). Among
domized clinical trials to assess the efficacy of psychotherapies for them, Swanson, Nolan, and Pelham-IV Questionnaire (SNAP-IV),
BPD in adolescent populations. is used from 6 to 18 years. The Standard for Clinicians’ Interview
Methods.– Search terms were combined for borderline personality in Psychiatry (SCIP) is a method of assessment of cognition used
and randomized trials into 4 online databases in accordance with the for adult ADHD. It demonstrated that, regarding working memory
PRISMA criteria. Randomized clinical trials of children/adolescents and visuomotor tracking subscales, is sensitive enough to detect
with diagnosed BPD randomized to psychotherapy exclusively or changes but, up to date, it has not been used for child and ado-
to a control intervention were included. Study selection differenti- lescents. A lower likelihood for girls to manifest psychiatric and
ated stand-alone designs (in which an independent psychotherapy cognitive impairment than boys has been found in previous litera-
was compared with control interventions) from add-on designs ture. We aim to evaluate gender differences in SNAP test and SCIP
(in which an experimental intervention added to usual treatment test over a ADHD child adolescent population.
was compared with usual treatment alone). Statistical analysis was Methods.– We performed bivariate analyses with independent sam-
conducted on efficacy outcome variables using fixed- and random- ple t-test in 35 stable patients diagnosed of ADHD. Statistical
effects meta-analysis with Review Manager 5.3. procedures were carried out using IBM SPSS 21st version. ADHD
Results.– Psychotherapy had a significant and large effect on BPD cllnical and cognitive tests were performed by an experimented
symptoms at posttest (g = −0.89 [−1.75, −0.02], I2 = 90%), but not consultant in Child and Adolescent Psychiatrist of an outpatient
in follow-up (g = 0.06 [−0.26, 0.39], I2 = 0%) or overall (g = −0.56 clinic.
[−1.17, 0.06], I2 = 89%). Similarly, psychotherapy did not have a sta- Results.– An independent samples t-test was conducted to compare
tistically significant effect on externalizing symptoms (g = −0.28 SNAP and SCIP subscores and total score for males and females.
[−0.69, 0.13]), internalizing symptoms (g = 0.02 [−0.26, 0.31]), or There were no significant differences in scores regarding cognitive
functioning (g = −0.04 [−0.26, 0.18]). (Figure 1) variables and SNAP score except for speed processing (M = 10.28,
SD = 2.74 for males and M = 12.50, SD = 2.33; t (35) = -2.09, p = 0.044).
Conclusions.– This preliminary data suggests that SCIP test may be
a useful tool for measuring gender differences. Validity and repro-
ducibility studies should be performed to confirm this hypothesis.
We did not find statistical differences regarding SNAP so further
studies with bigger samples would be necessary.
interest statement.
E-PP0127
Polymorphism of folate cycle genes in
children with autism spectrum
disorders
S. Biziukevich
Grodno State Medical University, Department of Psychiatry and
Addiction Medicine, Grodno, Belarus
Background and aims.– In recent years, there has been an increase in
Figure 1. Results: Psychotherapy. the incidence of autism spectrum disorders (ASD) among children
in different countries. According to literature sources, it is known
Conclusions.– Psychotherapies, most notably dialectical behavior that the polymorphism of MTHFR C677T gene is a genetic risk factor
therapy approaches, are effective for BPD symptoms and related for the development of ASD, and the allele of MTHFR A1298C gene
problems in adolescents. Nonetheless, effects are small, inflated plays the role of an additional aggravating factor. The purpose of
by risk of bias and publication bias, and particularly unstable at this study is to investigate polymorphism of genes of folate cycle
follow-up. in children with ASD.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– The study included 36 children with autism spectrum
interest statement. disorders aged 2 to 9 years. Identification of polymorphisms of
genes of folate cycle was performed by polymerase chain reaction.
Results.– In children with autism spectrum disorders polymor-
phisms in genes were as follows: MTRR (A66G) 85.6% (51.4% AG,
34.2% GG), in MTHFR (C677T) gene 65.7% (48.5% CT, 17.2% TT). The
polymorphism of MTR gene (A2756G) was 37% of the cases (31.4%
AG, 5.6% GG), MTHFR (A1298C) gene in 34.1% (34.1% AC, 0% CC).
Conclusions.– In this study, it was found that in children with ASD
polymorphisms of genes MTRR (A66G), MTHFR (C677T) prevailed.
In 17.2% of cases there was polymorphism in the homozygous state, bances are assessed with the PSQI questionnaire and additional
mainly – the most severe MTHFR T677T. questions (qualitative aspects, antecedents). Diagnosis was regis-
Disclosure of interest.– The authors have not supplied a conflict of tered (CIM10) and then confirmed six months later.
interest statement. Results.– 50 patients were included. Average age was 18.6 years.
Diagnostics post six months were: schizophrenia 28%, mood dis-
order 44%, anxiety disorder 6%, personality problem 24%, short
E-PP0128 psychotic episode: 2%, others 14%. 88% were considered as bad
Brain stimulation in child and sleepers and 52% as insomniacs. Patients diagnosed after six
adolescent psychiatry months with mood disorders (44%) and schizophrenia (28%) pre-
Y. Bloch* , H. Maoz, U. Nitzan sented more sleep disturbances (insomnia: respectively 32% et 8%)
Shalvata, Research Unit, Hod Hashron, Israel than the other ones (p (Fisher) = 0.012 et 0.059 Fischer). All patients
* Corresponding author. suffering from mood disorder were bad sleepers.
Conclusions.– Sleep disturbances are highly prevalent in young
Background and aims.– Adolescent depression is a severe life threat- patients, allbeit rarely evaluated and treated. Patients suffering
ening disorder affecting 5–8% of adolescents. It is a major risk factor from mood disorder are the more impacted. This could help to
for adolescent suicide. It carries with it a heavy burden of harsh determine long-term diagnosis.
co morbidities such as substance abuse, and behavioral problems. Disclosure of interest.– The authors have not supplied a conflict of
A substantial part of sufferers do not achieve a stable remis- interest statement.
sion with psychotherapy or pharmacotherapy. Brain stimulation
techniques open new therapeutic opportunities. Electroconvulsive
therapy (ECT) has been used successfully in open studies in ado- E-PP0130
lescents. In adult depression robust evidence is accumulating for Structure of disturbances in mental
the role of transcranial magnetic stimulation (rTMS) as a treatment development in children with
option in depression, currently has FDA approval as second line to
opsoclonus-myoclonus syndrome
treat depression. rTMS demands no anesthesia and is considered
N. Burlakova1* , Y. Fedorova1 , Y. Mikadze1 , R. Bembeeva2 , E.
extremely safe with few and generally insignificant side effects.
Ilyina3 , N. Zavadenko2
Since the hypothesis is that it mediates its’ effect by brain plasticity 1 Lomonosov Moscow State University- Faculty of Psychology,
it is not surprising that young age is a good prognostic factor for
Department of Neuro- and Pathopsychology, Moscow, Russia; 2
the use of rTMS.
Pirogov Russian National Research Medical University- Ministry of
Methods.– We will review our previous work with both ECT and
Health of Russia- Faculty of Pediatrics, Department of Neurology-
rTMS, and present our ongoing double blind placebo controlled
Neurosurgery and Medical Genetics, Moscow, Russia; 3 Russian
deep rTMS study.
Children’s Clinical Hospital- Ministry of Health of Russia,
Results.– The open label results of open label studies on both ECT
Psychoneurology Department, Moscow, Russia
and rTMS are promising with few side effects. Still approval of well * Corresponding author.
controlled studies in the field is difficult and patient recruitment is
an obstacle. Background and aims.– Opsoclonus-myoclonus syndrome (OMS) is
Conclusions.– It seems that lack of awareness of child and adolescent a severe neurological disorder often accompanied by mental distur-
psychiatrists is a significant difficulty in having more research and bances. Psychological structure of mental development disorders
clinical use of brain stimulation to treat adolescent depression. and positive trends in mental development were not researched
Disclosure of interest.– The authors have not supplied a conflict of previously.
interest statement. Methods.– The aim of the research was to analyze positive and neg-
ative trends in mental development of children suffering from OMS.
The research included 26 OMS-children aged from 1 year 7 months
E-PP0129 to 13 years. Following methods were used: analysis of patient’s
Self-assessment of sleep disturbances: development and medical record, semi-structured interviews with
prospective observational study parents and doctors, observation of child’s psychological condi-
during first psychiatric episode tion during psychological examination, neuropsychological and
pathopsychological assessment.
amongst teenagers and young adults
Results.– Positive trends in mental development (understanding
F. Brunet1* , S. Guessoum2 , A. Couturier3 , S. Tebeka3 , E. Kiesmann3 ,
simple speech; general cognitive interest, orientation in everyday
N. Mazer3 , Y. Le Strat3 , J. Mallet3 , C. Dubertret3
1 Hopital Louis Mourier- Institut Mutualiste Montsouris, 75, Paris, representations and knowledge about body; readiness for commu-
nication and cooperation with adults) were indicated. A stable set of
France; 2 Hopital Louis Mourier, Colombe, Colombe, France; 3 Louis
the most vulnerable mental processes was detected; it depended
Mourier, Colombes, Colombes, France
* Corresponding author. on different factors, such as disease onset time, age at the time
of assessment, severity of neurological disorders. We diagnosed
Background and aims.– Most psychiatric disorders start during neurodynamic features of mental processes with predominance of
teenage years and diagnosis is difficult to make during this prodro- tardiness (77%, 20 of 26), impulsivity (23%, 6 of 26); speech dis-
mal time. It therefore begs the question to fine tune the detection orders with predominance of autonomic speech (before 5 years)
of the first symptoms of psychiatric disorders. Besides, patients and delay in expressive speech (after 5 years), impairments in fine
frequently complain about sleep disturbances. It could be inter- motor skills (77%, 20 of 26); visual and spatial deficits (81%, 21 of
esting to evaluate how/when sleep disturbances arise during the 26).
prodromal period of mental disorders. Conclusions.– A stable set of the most vulnerable mental processes
Aims.– To determine (1) the prevalence of sleep disorders in young in children suffering from OMS was detected. Positive and nega-
adults and adolescents and (2) whether sleep disturbances can be tive trends in mental development suggest potential compensation
used as a predictive marker of conversion towards a specified men- resources that should be used for the psychocorrection and reha-
tal disorder. bilitation.
Methods.– It is an observational, prospective study amongst young Disclosure of interest.– The authors have not supplied a conflict of
adults hospitalized for the first time in psychiatry. Sleep distur- interest statement.
E-PP0131 feasibility, acceptability and efficacy of a CBT treatment programme

Antecedents of playing games in a series of children with MUS.
behavior of adolescents in chiang mai, Methods.– The study took place in a national and specialist Paedi-
atric Liaison psychiatry service and 6 participants aged 12–16 were
Thailand recruited. A mixed methods design was employed; quantitative
S. Chupradit1* , T. Sangyantanatam1 , C. Mhahawan1 , N.
data explored pre and post intervention levels of depression and
Kaewmamuang1 , S. Sawatla1 , A. Somnasak1 , N. Kienngam2
1 Chiang Mai University, Department of Occupational Therapy-
GAD (RCADS), quality of life (PedQL), overall functioning (CGAS)
and levels of alexithymia (AQC & CAM) based on both parent and
Faculty of Associated Medical Sciences- Chiang Mai University-
child reports. Qualitative data was collected via semi-structured
Chiang Mai- Thailand., Chiang Mai, Thailand; 2 Chiang Mai
interviews with participants and their parents.
University, Chiang Mai University Demonstration School- Faculty of
Results.– Quantitative data outcomes showed trend for improved
Education- Chiang Mai University- Chiang Mai- Thailand., Chiang
quality of life, overall functioning and reduction in alexithymia.
Mai, Thailand
Qualitative data identified themes of loss of control, disability and
change in ability to express emotions.
Background and aims.– Game Addiction in child and adolescents Conclusions.– CBT with an anxiety focus may be acceptable and
who use games will be exposed to more in the future that presents effective in this group and can be developed further for larger RCTs.
an incresed rate of youths in Thailand. Addiction to online games Disclosure of interest.– The authors have not supplied a conflict of
among Thai youths is rising alarmingly with latest survey show- interest statement.
ing almost 3 million youths have been addicted, thus prompting
parental worry about their kids’ health and behavior (Chanvit,
E-PP0133
2013). Internet Gaming Disorder (IGD) has been recently added as a
clinical diagnosis in Section III of the DSM-V (American Psychologi- Humiliation, emotional experiences
cal Association, 2013). The purpose of this research were 1) to study and emotion regulation processes in
game playing behavior and 2) to examine a causal relation model adolescents
of game playing behavior of adolescents in Chiang Mai, Thailand. M. Cunha1* , J. Pereira2 , A. Galhardo1 , T. Carvalho1
Methods.– The sample consisted of 496 adolescents by 12–18 1 ISMT- CINEICC - Universidade de Coimbra, Clinical Psychology,
years old. The sample was selected by the stratified random Coimbra, Portugal; 2 ISMT, Clinical Psychology, Coimbra, Portugal
sampling method. The data were collected using questionnaires, * Corresponding author.
Game Addiction Screening Test (GAST), Rubin’s Self Esteem Scale
and Suanprung Stress Test-20 (SPST-20). Data were analyzed Background and aims.– Humiliation is an emotion linked to suffer-
by utilizing descriptive statistics and Structural Equation Models ing, leading to isolation and causing a harmful impact. This emotion
(SEM). may be related to other relevant concepts such as negative emo-
Results.– The results showed that the game playing behavior could tional experiences and emotion regulation processes.
be categorized into 3 levels of game addiction: 1) Serious: prob- Objective.– Explore the association between humiliation, shame,
lematic addiction 2) Moderate: obsession, and 3) non-problematic bullying experiences and self-compassion in adolescence. Investi-
addiction. The proposed model was modified to fit with the empiri- gate gender differences, and age effect. Compare the study variables
cal data that causal variable explain self esteem had negative direct in participants attending public schools and the ones in foster care.
effect on game playing behavior but stress had no direct effect on Analyse the set of variables that predicts humiliation.
game playing behavior. Methods.– The sample included 200 adolescents (91 boys and 109
Conclusions.– However, The research suggest that we should be girls, including 49 girls in foster care and 151 in public schools)
more attractive activities and involved in changing behavior of with ages between 12 and 18 years old. Participants completed the
game addiction in adolescents. Peer Relationships Questionnaire (PRQ), Humilation Inventory (HI),
Disclosure of interest.– The authors have not supplied a conflict of Others as Shamer (OAS) and Compassion Attributes and Actions
interest statement. Scales (CAAS).
Results.– Girls showed higher scores regarding humiliation and
shame, as well as compassionate attributes and actions. Age was
E-PP0132 positively associated with humiliation. Participants in foster care
Evaluation of cognitive behavioural revealed significantly higher scores in humiliation, shame, pre-
disposition to provoke others and propensity to be victimized.
therapy (CBT) for anxiety in
They presented lower scores in compassion for others. Humil-
presentations of medically iation was positively associated with shame and tendency to
unexplained symptoms (MUS) in being victimized. It showed a negative association with self-
children and young people: an compassion actions. The humiliation predictor model included
exploratory multiple case study shame and the tendency to be victimized, explaining 63% of
M. Cooney1* , H. Bhatt1 , B. Baig1 , A. Cobbald2 , S. Dunsmuir2 variance.
1 South London & Maudlsey NHS Foundation Trust, Child and Conclusions.– A better understanding of humiliation and shame is
Adolescent Mental Health Liaison Service, London, United Kingdom; 2 presented, showing how these may be associated with interper-
University College London, Division of Psychology, London, United sonal experiences. Particularly in adolescents in foster care it is
Kingdom relevant to address these variables in order to design psychological
* Corresponding author. interventions that minimize their harmful impact.
Background and aims.– Children with Medically Unexplained Symp- interest statement.
toms (MUS) have high physical and psychiatric morbidity but
compared with adults, there exists little evidence for effective
treatment strategies and few RCTs. Clinical anxiety is a frequent
symptom for children with MUS. We hypothesize that using CBT to
treat dimensional anxiety in MUS may serve as a basis for devel-
oping new treatment strategies. This study aims to explore the
E-PP0134 placed on the waiting list and having received the usual care. We
Somatic complaints in parents of assessed intelligence, cognitive flexibility, memory, inhibition, and
children with somatization: is there a planning.
Results.– The average age of these children was 11.17 years old.
relationship? After an average duration of 7.27 months, we noticed a signifi-
M. Daoud* , M. Hamza, S. Bourgou, F. Charfi, A. Belhadj
cant improvement in group 1 compared to the control group in
Mongi Slim Hospital, department of Child and Adolescent Psychiatry,
this following cognitive functions : intelligence (p = 0.004) versus
Tunis, Tunisia
(p = 0.105), cognitive flexibility assessed by semantic verbal flu-
ency tests (p = 0.046) (p = 0.045) and phonemic verbal fluency
Background and aims.– Medically unexplained symptoms are fre- test (p = 0.035) versus (p = 0.919) (p = 0.306) (p = 0.084), inhibition
quently reported in psychiatric clinical samples of children and assessed by the Hayling test (p = 0.026) versus (p = 0.593), plan-
adolescents. What somatic symptoms are found in parents of chil- ning evaluated by the RCF (p = 0.003) (p = 0.000) versus (p = 0.533)
dren who somatize? (p = 0.182).
Objectives.– To explore somatic complaints in parents of somatizing Conclusions.– This pilot study shows that CRT is an effective
children and adolescents and factors conditioning their relation- therapeutic alternative to improve the different executive deficit
ship. functions in children followed for specific learning disorders.
Methods.– Retrospective cross-sectional study on Tunisian children Disclosure of interest.– The authors have not supplied a conflict of
and adolescents with a negative somatic workup, referred for emo- interest statement.
tional or behavioral problems and their parents. Child somatization
was explored via child and parent reports using the Children’s
E-PP0136
Somatization Inventory (CSI-24). Parental somatic complaints were
explored using the Patient Health Questionnaire 15 (PHQ15). Suicide in maori youth – reflections
Results.– Ninety-six patients were recruited accompanied with on the aetiology and evolving
their fathers in 13,5% of cases and their mothers in 86,5% of cases. management responses
Their average age was of 10,7 years with a sex ratio of 1,2. Patients O. Egan
were diagnosed mainly with depressive disorders (46,9%) and anx- College of Psychiatrists of Ireland, University Hospital Kerry, Tralee,
iety disorders (16,7%). Mean score on the CSI-Child report was Ireland
40,9. It was significantly correlated with parents’ reports (p = 0,000). Background and aims.–
Parents were classified according to PHQ15 scores into moderate Introduction.– This is an overview of the title subject, which
somatization disorder (77,1%) and severe somatization disorder explores its complex problematic in Maori youth. It discusses man-
(22,9%). Children scored significantly higher on CSI-24 in this latter agement at a local and national level, referencing the author’s
group (mean: 51,6 vs 37,8; p = 0,008). When comparing the occur- experience within the New Zealand Mental Health Service.
rence of each somatic symptom jointly in children and parents, Objectives.– To assess the extent, aetiology and societal and cultural
headaches and limb pain were more prevalent in children when factors which account for New Zealand having the highest rates of
they were experienced by their parents (respectively p = 0,023, youth suicide within OECD countries, in which Maori Youth are
P = 0,017) but not abdominal, back or chest pains. disproportionately over-represented to an alarming degree.
Conclusions.– Parental somatic complaints can influence the fre- Methods.– Review of current literature, data analysis of media
quency and type of childrens’ somatization. The degree of this reporting, review of national and local initiatives in New Zealand
influence is dependent on many factors including severity of and the author’s experience.
parental somatization. Results.– The results confirm increasing suicide rates and the criti-
Disclosure of interest.– The authors have not supplied a conflict of cal influence of societal and cultural determinants. These include a
interest statement. complex of factors which include: a macho culture, child poverty,
parental unemployment, domestic violence, teenage pregnancy
and school bullying. The development of creative management
E-PP0135 strategies are outlined, describing how they are constrained by
Impact of cognitive remediation overstretched human and other resources.
therapy on executive functions in Conclusions.– Suicide within the selected population is increasing.
children with specific learning It is complex in its aetiology and effective management is resource
constrained. It is now a politically charged subject within New
disorders: about a pilot Tunisian Zealand’s parliament.
experience Disclosure of interest.– The authors have not supplied a conflict of
M. Boudali1 , Z. Abbes1 , H. Ben Yahya2 , M. Hajri1 , H. Hemidi2 , M. interest statement.
Daoud1* , S. Halayem1 , A. Bouden1
1 Doctor, Child and Adolescent Psychiatry Department- Razi Hospital
UR12SP20 and Faculty of Medecine of Tunis, Tunis, Tunisia; 2 E-PP0137

Psyhologist, Child and Adolescent Psychiatry Department-Razi Gastrointestinal symptoms in children
Hospital UR 12SP20 and Faculty of Medecine of Tunis, Tunis, Tunisia
* Corresponding author. with autism spectrum disorders and
correlation with autism functionality
Background and aims.– Specific learning disorders would be due and severity: a case-control study
to a dysfunction of the executive functions. The objectives of our R. El Khatib1,2* , A. Hajj2,3 , S. Hallit4,5 , T. Itani1,2 , D. Karam Sarkis1,2
study were to assess the contribution of cognitive remediation ther- 1Saint-Joseph University, Microbiology Laboratory- Faculty of
apy (CRT) in the management of children with specific learning Pharmacy, Beirut, Lebanon; 2 Saint-Joseph University, Faculty of
disorders compared to a control group. Pharmacy, Beirut, Lebanon; 3 Saint-Joseph University, Laboratory of
Methods.– This is a prospective, descriptive, case-control exper- Pharmacology- Clinical Pharmacy and Quality Control of Drugs-
imental study that included 27 patients followed for specific Faculty of Pharmacy- Pôle Technologie- Santé PTS- Faculty of
learning disorders. They were recruited from school and clinical Pharmacy, Beirut, Lebanon; 4 Holy Spirit University of Kaslik USEK,
populations. They were divided into two groups : A first group of 17 Faculty of Medicine and Medical Sciences, Beirut, Lebanon; 5
patients included in CRT program and a second group of 11 patients
INSPECT-LB: Institut National de Santé Publique, Epidémiologie history and environmental factors that can affect sIgA levels were
Clinique et Toxicologie, Beirut, Lebanon also assessed.
* Corresponding author. Results.– Mean sIgA levels were significantly lower in ASD children
(1493 ␮g/ml) compared to healthy ones (6370 ␮g/ml; p < 0.001).
Background and aims.– Gastrointestinal (GI) dysfunctions have Results of the bivariate analysis showed that gender, presence
often been reported in children with Autism Spectrum Disorders of ASD, number of antibiotic treatment taken during the first
(ASD) and are recently recognized as a comorbid condition. three years of life, type of diet and severity of GI symptoms
We aimed to assess potential association between GI disorders and were significantly correlated to sIgA level (p < 0.05). Only the first
ASD functionality and severity. three variables remained significantly associated to sIgA level in
Methods.– We conducted a Lebanese multicentric (n = 13) case- the multivariable analysis. Hence, male gender (Unstandardized
control study (142 ASD children versus 124 age-matched healthy Beta = −2355.85; p = 0.026), the presence of ASD (Unstandardized
children) to identify whether GI dysfunctions could be corre- Beta = 2125.15; p < 0.001) and undergoing increased oral antibi-
lated with ASD. We then aimed at assessing if these GI disorders otic treatment during childhood (Unstandardized Beta = −6121.7;
could be associated with functionality and severity in the group p = 0.029) were associated with lower sIgA levels thus a reduced
of ASD children. GI symptoms were assessed using the Gastroin- intestinal mucosal immunity.
testinal Symptoms Rating Scale (GSRS) and problem behaviors Conclusions.– These findings may suggest the presence of an under-
were assessed using the Arabic validated version of the Childhood lying immune function deficiency in ASD children. Further studies
Autism Rating Scale (CARS). The local ethical committee approved are warranted to determine whether sIgA can be used as a potential
the study and all parents gave their written consent (Reference: biomarker for ASD.
USJ-2016-84). Disclosure of interest.– The authors have not supplied a conflict of
Results.– GI disturbances were more frequently reported in ASD interest statement.
children (76%) compared to healthy controls (15%). The results of
the bivariate analysis showed a significantly higher mean GSRS
score in ASD children (score = 2.58) compared to healthy ones E-PP0139
(score = 1.51; p < 0.001). When evaluating the functionality of ASD Study of some possible metabolic
children, the analysis showed no significant correlation between
the GSRS score and the functionality (p = 0.697). However, a sig-
alterations among autistic male
nificantly higher mean GSRS score was found in children with children with correlations to disease
severe autism (score = 2.84) compared to those with moderate severity
(score = 2.37; p = 0.018) and mild autism (score = 1.74; p = 0.007). M. Hassan1 , T. Desoky2 , H. Sakhr3 , R. Gabra4* , A. Helmy3
1 Faculty of Medicine- South Valley University- Qena-Egypt.,
Conclusions.– Our results indicate that autism symptoms may
derive, at least in part, from underlying GI problems. This emerg- Department of Medical Biochemistry-, Qena, Egypt; 2 Faculty of
ing evidence could speed up diagnosis and treatment initiation and Medicine- South Valley University- Qena-Egypt., Department of
ultimately improve the quality of life of ASD children. Neuropsychiatry, Qena, Egypt; 3 Faculty of Medicine- South Valley
Disclosure of interest.– The authors have not supplied a conflict of University- Qena-Egypt., Department of Pediatrics, Qena, Egypt; 4
interest statement. Faculty of medicine-Assiut University, Department of
Neuropsychiatry, Assiut, Egypt
E-PP0138
Secretory IGA levels in the stool of Background and aims.– The present study has been designed for
undertaking and delineating some aspects of metabolic derange-
children with autism spectrum ments that may occur in ASD.
disorder: a case-control study Methods.–
R. El Khatib1,2* , A. Hajj2,3 , S. Hallit4,5 , T. Itani1,2 , D. Karam Sarkis1,2 Design.– Cross-sectional, hospital based study.
1 Saint Joseph University, Microbiology Laboratory- Faculty of Patients and Methods.– 73 autistic male children have been
Pharmacy, Beirut, Lebanon; 2 Saint Joseph University, Faculty of recruited from the outpatients’ psychiatric clinics of the Neu-
Pharmacy, Beirut, Lebanon; 3 Saint Joseph University, Laboratory of ropsychiatric and Pediatric Departments of South Valley and
Pharmacology- Clinical Pharmacy and Quality Control of Drugs- Assiut University Hospitals. Serum cholesterol and some its steroid
Faculty of Pharmacy- Pôle Technologie- Santé PTS- Faculty of hormones derivatives were measured using ELISA assay kits.
Pharmacy, Beirut, Lebanon; 4 Holy Spirit University of Kaslik USEK, Biochemical assessments of mitochondrial dysfunction, oxidative
Faculty of Medicine and Medical Sciences, Jounieh, Lebanon; 5 stress and heavy metals (mercury, lead and aluminium) were done.
INSPECT-LB: Institut National de Santé Publique- Epidemiologie Mean ± SD was calculated for all measured values.
Clinique et Toxicologie, Departement d’Epidemiologie, Beirut, Results.– There were significant higher plasma lactate, serum
Lebanon pyruvate, lactate/pyruvate ratio, CK, PK, LDH and ammonia, with
significant lower serum L-carnitine and urea levels among autistic
children versus the controls, with p < 0.05 for all. Those were asso-
Background and aims.– Gastrointestinal (GI) disturbances, com-
ciated with significant higher blood heavy metals levels, serum
monly reported in children with Autism Spectrum Disorder (ASD),
total oxidant status, oxidative stress index with significant lower
have previously been associated with dysbiosis of the gut micro-
serum total antioxidant capacity, with p < 0.05 for all. There were
biota.
significant lower serum total cholesterol, cortisol and estradiol
Considering the mutual interaction between the gut microbiota
with significant higher serum levels of DHEA and free testosterone
and the intestinal immune system, we investigated secretory
among autistic children when compared with the controls, with
Immunoglobuline A (sIgA) levels as an indicator to assess the
p < 0.05 for all (figure 1).
mucosal immunity of ASD children.
Methods.– A Lebanese multicentric (n = 13) case-control study was
conducted. Stool sIgA levels of 50 ASD children and 50 age-
matched healthy children were measured using ELISA (Quick
DNATM Fecal/Soil Microbe Miniprep Kit, Zymo Research, California,
USA). Risk factors including socio-demographic factors, medical
Conclusions.– In addition to describing the study design and initial

results, I will also describe the ABCD study’s open science model
wherein any investigator can have complete, free access to this very
large dataset.
interest statement.
E-PP0141
Evaluation and validation of a
program for children with asd in
public child psychiatry
N. Garret1* , G. Apter2 , F. roos-weil3
1 CHU Nantes, Loire Atlantique, Nantes, France; 2 Université Rouen
Normandie, Seine Maritime, Le Havre, France; 3 CH Maison Blanche,
Seine, Paris, France
Background and aims.– The integrative program in place in public

Figure 1. Correlations of oxidative stress with performance I.Q (A
child psychiatry in France is built on a shared theoretical and prac-
and B) and short sensory profile (C and D).
tical basis. It is formalized according to a certified methodology and
Conclusions.– Several metabolic abnormalities have been encoun- is the subject of performance research. Children, most of whom are
tered among autistic children who could be helpful in establishing a from families with low socio economic backgrounds received inten-
medical protocol for therapy or at least improving the health status sive day care programs. Interventions are defined and implemented
and quality of life of these children following functional and psychopathological analysis. Programs are
Disclosure of interest.– The authors have not supplied a conflict of adapted to each individual child, tailoring integrative care while
interest statement. maintaining essential objectives toffee ASD developmental chal-
lenges. In order to better identify therapeutic results, we designed
a clinical research to identify appropriate integrative interventions
for very young children with ASD in a public health care setting
E-Poster Presentation: Child and Adolescent according to the severity of their symptoms
Psychiatry - Part II Methods.– A multi-centric and prospective research over a one-year
period, for 90 children between 3 and 6 years with a diagnosis ASD.
The results are presented according to patient-profile severities.
E-PP0140 The main objectives of evolution was improvement of criteria from
PEP-3.
Initial neuroimaging findings from
Results.– Each child showed heightened skills after one year of inte-
the adolescent brain cognitive grative treatment. The most severe symptomatic situations highly
development (ABCD) study benefited from this “customized” integrative treatment process.
H. Garavan We will describe the details and highlight the originality of our
University of Vermont, Psychiatry, Burlington, USA treatment program.
Background and aims.– Conclusions.– Il could be usefully to understand how tailored care
Introduction.– Adolescence is characterized by substantial changes could be implemented to larger groups of children with ASD, in
in physical and neurobiological development in which many order to address individual symptomatology. We believe more clin-
symptoms of psychopathology first emerge. Understanding the ical research is needed with “hands-on” approach.
numerous influences that impact on neurotypical development and Disclosure of interest.– The authors have not supplied a conflict of
how they relate to the risk for psychopathology motivated the ABCD interest statement.
study. ABCD is a multisite US study of almost 12,000 children aged
9 and 10 who are being followed for ten years with very rich, multi-
modal assessments including neuroimaging, genetics, family, social E-PP0142
and psychological factors. Psychogenic movement disorders in
Objectives.– I will present initial findings on the task functional child psychiatry: from diagnosis to
neuroimaging data acquired on the sample at baseline.
Methods.– All participants completed the same task battery includ-
treatment
R. Khemakhem, M. Hajri, O. Rajhi, M. Ghazzai* , Z. Abbes, S.
ing the STOP task (measuring executive functions through motor
Halayem, A. Bouden
response inhibition), a Monetary Incentive Delay task (measuring
Razi Hospital, Child and Adolescent Psychiatry, Manouba, Tunisia
reward processes through the anticipation and receipt of rewards * Corresponding author.
and losses), and an Emotional N-Back task (measuring working
memory through the maintenance of place and affective face stim- Background and aims.– Illustrate the clinical difficulties faced by the
uli). child psychiatrist with tics.
Results.– Task activation of each task shows broadly similar acti- Methods.– Illustration by case reports then review of the liter-
vation patterns to what has been observed for these tasks in ature by research carried out on the Pubmed and Sciencedirect
adolescent and adult studies. Critically, activation patterns show databases using the following key words “movement disor-
robust individual differences which bodes well for the ultimate goal ders”, “tic disorders”, “child psychiatry”, “Tourette syndrome”,
of linking variation in brain function at a young age to subsequent “Obsessive-Compulsive Disorder”.
developmental trajectories. The longitudinal data will reveal the Results.– Case report 1: A F, 10 years old, followed up since he was 7
extent to which this variation predicts important mental health years old for school difficulties, depressive symptoms and Separa-
outcomes. tion Anxiety Disorder. Family described him as an obsessive person.
He presented since a year complex motor tics and vocal tics (anar- Disclosure of interest.– The authors have not supplied a conflict of
chic general movements, coprolalia). Neurological explorations did interest statement.
not reveal any abnormalities. We diagnosed a Tourette syndrome
and atypical antipsychotic was started with partial response.
Case report 2: A B, 9 years old, followed up for depressive symptoms E-PP0144
(psychomotor instability, aggressive behaviors, school difficulties, Youth impulsivity in Southern
chronic boredom), trichotillomania and familial robbery. He pre- Bulgaria
sented simple (blinking) and complex motor tics (circular lips V. Giannouli1* , S. Stoyanova2
movements) associated with contamination’s obsessive ideations. 1 Organisation Against Drugs, Okana, Athens, Greece; 2 South-West
We diagnosed Obsessive-Compulsive Disorder with Tic-related and University “Neofit Rilski”, Department of Psychology, Blagoevgrad,
treatment based on antidepressant and classic antipsychotic was Bulgaria
prescribed. * Corresponding author.
Case report 3: M B, 14 years old, presented chronic vocal and
motor tics (scraping of the throat, blinking, head shaking) evolv- Background and aims.– Impulsivity is a multi-faceted construct,
ing since 5 years. The symptoms were in conflict’s situations with including both functional and dysfunctional aspects on the basis
secondary benefits. After the absence of structural or electroen- of speed and accuracy of information processing, effectiveness of
cephalographic abnormality in neurological exam, we diagnosed the decisions that were taken, and their positive or negative out-
a Conversion Disorder with abnormal movements and behavioral comes. The aim of this study was to investigate the prevalence of
therapy was started with good evolution. two types of impulsivity in youth.
Conclusions.– Using illustrative case histories, this review draws Methods.– Functional and Dysfunctional types of impulsivity were
attention to the practical difficulties in diagnosis and management studied among 458 students (age: 18 to 27) by means of a self-
of child movement disorders. report paper-and-pencil questionnaire (Radoslavova & Velichkov,
Disclosure of interest.– The authors have not supplied a conflict of 2005).
interest statement. Results.– Results indicated that Functional impulsivity was
expressed more frequently in medium level (among 70.1% of the
participants), but Dysfunctional impulsivity was reported mainly
E-PP0143 in high level (55.2%). The frequent high Dysfunctional impulsiv-
Parental mental health and quality of ity may mean more attention deficits in youth and difficulties in
life of Tunisian children and accuracy and precision of information processing that may result
in life-threatening behaviours. Dysfunctional impulsivity was dif-
adolescents with type 1 diabete:
ferentiated by the size and density of population in the place of
what’s the link? living (Kruskall Wallis coefficient = 8.242; df = 2; p = .016).
R. Khemakhem1 , Y. Dridi2 , M. Hamza1 , A. Ben Hamouda1 , M. Conclusions.– Dysfunctional impulsivity increased with the aug-
Ghazzai1* , N. Siala2 , A. Belhadj1 mentation of the size of place of living, as well as with the
1 Mongi Slim Hospital, Child and Adolescent Psychiatry, La Marsa,
augmentation of density of population of place of living. This find-
Tunisia; 2 Mongi Slim Hospital, Pediatrics and Neonatology, La ing reveals that the inhabitants of the more densily populated and
Marsa, Tunisia big cities were more prone to make quick ineffective decisions, act-
ing without thinking about the outcomes and this may imply more
frequent antisocial and deviant behaviour and aggression in the
Background and aims.– Measure the health related quality of life
more densily populated and big cities. Future research should fur-
(QoL) among Tunisian children and adolescents with type 1 Melitus
ther clarify if the above findings regarding impulsivity are similar
Diabetes (T1MD) and the impact the disease has on the family.
in other cultural contexts.
Methods.– A cross-sectional study was conducted involving 34 chil-
dren aged 3–18 years with T1MD, diagnosed for at least 6 months
interest statement.
and their parents during the outpatient exam since september
2018. Children QoL was assessed by PedQol 3.0 Diabetes Mod-
ule containing five dimensions (Diabete, Treatment I, Treatment II,
E-PP0145
Worry, Communication); a higher score indicate lower problems.
The glycemic control was assessed by the last HbA1c level. Par- Metabolic disturbances in adolescents
ent’s QoL was measured by PedQol 4.0 and we assessed their coping admitted to a psychiatric day
behaviors and thoughts with the Brief COPE and their depressive hospitalization unit
and anxiety symptoms with the Hospital Anxiety and Depression A. Giménez Palomo* , S.P. Gomes, G. Anmella, J.E. Pinzón, A. Morer
Scale (HADS). Hospital Clínic of Barcelona, Psychiatry, Barcelona, Spain
Results.– Children mean QoL score was 79.97 (±14.7) and the Treat- * Corresponding author.
ment I’s dimension corresponded to the lower score (62.2 ± 25.3).

Longer is the disease’s evolution, worse was the level of HbA1C Background and aims.– Psychiatric patients are known to have an
(p = 0.03). The parents mean QoL score was 69.87 (±16.4) and sig- increased risk of presenting metabolic disturbances, which is trans-
nificantly correlated to children QoL (p = 0.022). Children QoL was lated in the necessity their control and prevention. Few literature
positively correlated to planning strategy (p = 0.071) and positive has been published about metabolic disturbances in young psychi-
reframing (p = 0.01) in parent’s coping and negatively correlated to atric population.
humor (p = 0.013). Higher scores at parent’s depressive dimension This study included a sample of the 48 patients who were above
were correlated to emotion focused coping (p = 0.015), behav- 12 years old and were admitted to our General Psychiatric Day
ioral disengagement (p = 0.00), self-blame (p = 0.005) and denial Hospitalization Unit in 2016.
(p = 0.021). A higher score at anxiety dimension was correlated to Body mass index (BMI), its variation after hospitalization and blood
planning (p = 0.049), emotion focused coping (p = 0.001) and self- cholesterol levels are described.
blame (p = 0.001). The main objective in this study is to check if basic metabolic data
Conclusions.– These findings emphasize the importance of an inter- are registered, describe them and find possible changes in BMI
disciplinary, biopsychosocial and family centered care approach to throughout hospitalization. This study is also focused on finding
patients with T1MD. high-risk groups comparing treatment groups.
Methods.– Retrospective analysis of clinical records of patients who E-PP0147

were between 12 and 17 years old and were admitted to our General Sensory disorders in children with
Psychiatric Day Hospitalization Unit in 2016.
ADHD – a cross-sectional study
Results.– They were 43.8% women and 56.2% men and had a mean
R. Gonçalves1* , M. Marques1 , S. Neiva1 , A.R. Pinto1 , S. Nogueira2 , J.
age of 14.9 years. The average of their cholesterol levels was
Boavida Fernandes2
153.7 mg/dL, and BMI at the end of the follow-up was 25.4, with 1 Hospital Pediátrico de Coimbra - Coimbra Hospital and University
a mean increase of 1.4. Patients who did not receive antipsychotics
Center CHUC, Child and Adolescent Psychiatry Department, Coimbra,
had mean cholesterol levels of 164 mg/dL and a BMI of 28.5, and
Portugal; 2 Hospital Pediátrico de Coimbra - Coimbra Hospital and
the other group had averages of 152.9 mg/dL and 25.0 respectively.
University Center CHUC, ADHD Unit- Child Development Center,
Conclusions.– The mean BMI at the end of follow-up was consistent
Coimbra, Portugal
with overweight, having increased during their hospitalization, * Corresponding author.
which was not explained by antipsychotics.
It is crucial to implement a protocol to detect metabolic distur- Background and aims.– Parents of children with attention deficit
bances in young psychiatric population in order to prevent future hyperactivity disorder (ADHD) frequently report that their chil-
morbidity. dren exhibit unusual responses to sensory experiences. However,
Disclosure of interest.– The authors have not supplied a conflict of despite the evidence of impact in other neurodevelopmental dis-
interest statement. orders, little research is available, analyzing sensory disorders in
these children.
The aim of this study is to assess the prevalence and impact of
E-PP0146 Sensory Processing Disorders (SPD) in children with ADHD.
Worldwide overlook on the Methods.– In a cross-sectional evaluation, the Portuguese version of
differences in child and adolescent the Sensory Processing Measure (SPM) was administered to parents
psychiatry training program. and teachers of children with ADHD (aged 6–12 years) recruited
from a Portuguese specialized outpatient clinic and to a control
Descriptive cross-sectional study group, recruited from a general pediatric outpatient clinic.
based on early career pscyhiatrists’ We tested the association of these sensory outcomes to clinical fac-
point of view tors, such as number of ADHD symptoms, comorbidities or IQ. Data
T. Gomez Alemany1* , A.S. Hansen2 , A. Moscoso3 will be analyzed using SPSS.
1 Complex Asistencial Salut Mental Benito Menni, Psychiatry, Sant Boi Results.– Since this study is currently ongoing, the authors will
del LLobregat, Spain; 2 Aalborg University Hospital - Denmark, only be able to provide final results and conclusions by the time
Psychiatry Department, Aalborg, Denmark; 3 Service Universitaire de of submission of our work presentation, by April 2019. However,
Psychiatrie de l’Enfant et de l’Adolescent. Pr Speranza Centre according to the literature available, we are expecting to find sig-
Hospitalier de Versailles, CAP psychiatry, Versailles, France nificant higher scores of sensory difficulties in children with ADHD
compared with general population and an association between
some sensory processing patterns and the number of ADHD symp-
Background and aims.– Diversity in the psychiatry training program toms or some specific comorbidities.
can be hypothesized between countries worldwide. Nevertheless Conclusions.– SPD might be an under-recognized problem in chil-
there is a lack of knowledge when further details about these dif- dren with ADHD and have a substantial impact on daily functioning.
ferences are searched. It could be responsible for an important part of behavioral dis-
The main aim of the study is to disclose the differences regarding tress associated with ADHD. Sensory processing patterns should,
the CAP training program among different countries of different thereby, be considered when designing interventions for these chil-
continents. The specific objectives: 1) The possibility to pursue dren.
a CAP training program as specialty differentiated from general Disclosure of interest.– The authors have not supplied a conflict of
psychiatry, 2) Total years of training, 3) The trainees’ evaluation interest statement.
method.
Methods.– The European Federation of Psychiatry Trainees rep-
resents the consensus of trainee’s associations across European E-PP0148
countries and advocates for what training should look like regard-
Current status and future perspectives
less of the country. The CAP working group designed a cross
sectional survey aimed towards early career psychiatrists disclosed for child and adolescent psychiatry in
online among different countries and continents since June 2018. Mexico
Results.– More than 500 respondents from more than 50 countries D.P. Guizar-sanchez* , G. Heinze Martin, N. Bernard
were obtained. According to the results, a vast majority of trainees Universidad Nacional Autónoma de México, Posgraduate Unit,
are able to pursue a CAP training as a specialty itself in their own Mexico City, Mexico
country. The total length of the training program rangs between 4
and 5 years. Around 80% of the respondents states to have a final
Background and aims.– We will provide an update on advances in
mandatory exam in order to qualify as psychiatrist.
children’s mental health care in Mexico and the current data on the
Conclusions.– Major differences can be found across different coun-
number and geographic location of child and adolescent psychia-
tries worldwide. CAP training is separated in the majority of
trists (CAPs) in Mexico in order to know if mental health needs of
countries regardless Spain, Moldova and Georgia. Ireland has a
the country are being met.
training program of 6 years if duration in comparison to 2 years
Methods.– Using a descriptive and cross-sectional study, we exam-
in Ucraina, Azerbaijan and Russia.
ine how the current children’s mental health system operates in
Mexico, including recent changes in mental healthcare policy and
interest statement.
the need of a national mental health plan for children and ado-
lescents that should be well-integrated with the existing national
health and mental health plans. Several sources available in Mexico
were consulted to locate CAP and to identify where and what kind
of practice they have.
Results.– Prevalence rates of child mental disorders are up in Mexico E-PP0150

to twice as high as the U.S. and Canadian rates. Child and ado- School based empathy education and
lescent mental health services in Mexico are delivered through
anti-bullying programs. A systematic
an underfunded, underresourced, and uncoordinated network of
institutional providers isolated from the larger health care system.
review
There are only 234 CAPs in Mexico, or 0.62 CAP per 100,000 chil- M. Hafnaoui1* , M. Hajri2
1 Faculty of Medicine of Tunisia, Child and Adolescent Psychiatry,
dren, 56%practiced in Mexico City. There are 1.8male CAPs for every
female CAP. Only 40% are certified by the specialty board. Tunis, Tunisia; 2 Razi Hospital, Child and Adolescent Psychiatry,
Conclusions.– Future perspectives for the field are discussed in Tunis, Tunisia
terms of funding, research priorities, and research resources. The
number of CAPs in Mexico seems to be insufficient to cover the Keywords: empathy; bullying; programs; anti-bullying
needs of the country. Building a society that guarantees the right Background and aims.– Taking the example of Danemark in which
to mental health, adequate treatment, and rehabilitation are part empathy is a required part in their school curriculum, and based on
of our present challenges. the premise that children are not necessarily born with empathy,
Disclosure of interest.– The authors have not supplied a conflict of it seems clear that it is something they learn through education.
interest statement. This study focuses on publications about empathy education and
anti-bullying school programs, in order to assess their effectiveness.
Methods.– This article systematically reviews studies that were
E-PP0149
published in the science direct database during the last two
The relationship of anxiety disorders decades, in which school programs were conducted to promote
and asthma: is there specificity for empathy education in order to prevent bullying among 8 to 19
separation anxiety in psychiatrically years old children. We used predetermined keywords and strict
hospitalized youth? inclusion/exclusion criteria as to identify, screen, appraise, and syn-
S. Gupta1* , J. Kim2 , M. Chen3 , E. Reynolds3 , M. Grados3 thesize all relevant empirical studies.
1 Manipal Academy of Higher Education, Kasturba Medical College, Results.– A total of 19 articles composed the corpus of analysis and
Manipal, India; 2 Johns Hopkins University, Department of all were considered to have high methodological quality. Out of
Neuroscience, Baltimore, USA; 3 Johns Hopkins School of Medicine, them, 7 were from the US, 1 from Chile, 3 Canadian, 5 European
Psychiatry & Behavioral Sciences, Baltimore, USA (UK, Finland, Ireland, Norway, Italy), 2 from Turkey, 1 from Taiwan.
* Corresponding author. Different programs were evaluated, including the Olweus Bullying
Prevention Program (the most researched and best-known bul-
Background and aims.– Asthma is highly co-morbid with anxiety lying prevention program available today), the KiVa antibullying
disorders (x2.7) especially panic disorder, obesity (x2) and aller- program (a Finnish evidence-based program), as well as a mindful-
gic conditions. However, the type of anxiety disorder has not been ness based program and video games programs. All of them were
elucidated. In particular it is of interest to explore the relationship effective in changing children’s bullying knowledge, attitude, and
between separation anxiety disorder-a precursor of panic disorder- empathy.
and asthma due to breathing symptoms overlap and suggestion of Conclusions.– There is an urgent need for more rigorously evaluated
a common causal mechanism. and reported studies in low and middle income countries, adapted
Objective.– To explore the association between anxiety disorders for contexts of considerable resource constraints.
[social phobia (SoP), generalized anxiety disorder (GAD), and sep- Disclosure of interest.– The authors have not supplied a conflict of
aration anxiety disorder (SAD)] and asthma in a large pediatric interest statement.
inpatient psychiatry sample.
Methods.– Medical record data from 626 participants ages 5–17
years from a youth psychiatric inpatient service (Jan 2010-Jun E-PP0151
2014) included asthma diagnosis, type of anxiety disorder, sex, age, Catatonia in children
race, and estimated median household income. Frequency tables R. Hernández Antón1* , I.H. Marta2 , X. Edurne2
for anxiety, asthma, and other variables were subjected to chi- 1 Psiquiatría, Psiquiatría, Valladolid, Spain; 2 Complejo Asistencial de
square tests. Navarra, Psiquiatría, Pamplona, Spain
Results.– Of 626 youth inpatients, 135 had asthma (22%), while * Corresponding author.
78 had GAD (12%), 38 had SoP (6.1%), and 39 had SAD (6.2%).
Asthma was not associated with GAD (chi2 = 0.0028; p = 0.958), Background and aims.– Catatonia is a neuropsychiatric syndrome
SoP (chi2 = 0.2365; p = 0.627), but was marginally associated characterized by motor abnormalities that occur in association with
with SAD (chi2 = 3.4051 p = 0.065). Asthma was also not associ- changes in thought, mood, and vigilance. Kahlbaum first described
ated with presence of having any anxiety disorder (chi2 = 1.415; the syndrome in 1868, when he noted patients suffering from a
p = 0.234). However, when stratified by race (black/white) or condition of «profound mental anguish». In 1893, Kraepelin lim-
sex (male/female), SAD was significantly associated with asthma ited catatonia to a subtype of dementia praecox, and it was later
(chi2 = 4.3676; p = 0.037) in females, and more strongly in black redefined by Bleuler, in 1906, as catatonic schizophrenia.
females (chi2 = 5.5205; p = 0.019). Methods.– Clinical case: A 12-year-old man, who lives with his par-
Conclusions.– Asthma is specifically associated with SAD-a precur- ents and a 15-year-old sister. The sister has been diagnosed of
sor of panic disorder-in this youth psychiatric inpatient cohort, but schizophrenia and the father has been diagnosed of bipolar dis-
not SoP or GAD. Given the relationship between SAD, panic disorder order. He hadn’t psychiatric history. Two years ago he began to
and asthma, a common causal mechanism merits further study. participate less in class, he stopped going out to play and 3 months
Disclosure of interest.– The authors have not supplied a conflict of ago he was isolated at home and he presented changes in behavior
interest statement. with motor immobility, mutism and artificial posture and audi-
tory hallucinations. Medical tests: Complete analytics. study of
metabolic diseases and karyotype.MRI and EEG without alterations.
Results.– Clinical orientation: Schizophrenia. Catatonia associated
with schizophrenia. We started treatment with antipsychotics and
benzodiazepines.
Conclusions.– The specific manifestations vary and commonly Background and aims.– The article presents the results of a compar-
include mutism, stupor, stereotypies, mannerisms, diminished ative analysis of two diagnostic tools.
motor function (including waxy flexibility or rigidity), staring, The applied speech reveal violations of speech status, which aren’t
negativism, automatic obedience, echopraxia, and echolalia. Stereo- decisive in autism.
typies are purposeless repetitions of sounds, words, phrases, or Methods.– Comparative determination of the sensitivity of the
movements. Unexplained foreign accents, whispered or robotic developed method “Determination of speech disorders in children
speech, and tiptoe walking have also been observed. There are with autism” and the speech therapy method “Examination of the
two principal forms of catatonia: a hypokinetic retarded-stuporous speech of preschool children with mental retardation”.
variety and a hyperkinetic excited-delirious variety. Medical disor- Results.– The sample consisted of 609 people the age of 4 to
ders that can result in catatonia include heat stroke, autoimmune 7 years. Simultaneous diagnosis of children using the method
disease, uremia, hyperthyroidism, diabetic ketoacidosis, porphyria, “Determination of speech disorders in children with autism” and
and Cushing disease among other conditions. method “Survey of preschool children with mental retardation.” A
Disclosure of interest.– The authors have not supplied a conflict of two-factor analysis of variance was used, which was carried out
interest statement. according to a mixed scheme. The intergroup (the research group)
to which the subjects belonged (a group of normal children, a group
of children with the speech disorders and a group of children with
E-PP0152 childhood autism). The intragroup was the performance of both
Speech disorders diagnostics of diagnostic tools. As a dependent variable, the points scored by the
children with autism subjects on these indicators were considered.
S. Hreben1* , T. Dakukina2 , V. Zakharevich2 , S. Marchuk2 , A. Conclusions.– The study suggests that the method “Determining
Martynenka2 , T. Budzko2 , H. Shamarova1 speech disorders in children with autism” in relation to the method
1 Republican Scientific and Practical Center of Otolaryngology, “Speech examination of preschoolers with mental retardation” has
Psychoneurological Department for Children, Minsk, Belarus; 2 a higher sensitivity to the detection of speech disorders of children
Republican Scientific-Practical Center of Mental Health, Deparment with childhood autism age 4–7 years.
of Mental and Behavioral Disorders- Section Science, Minsk, Belarus Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– Early detection of speech children with

speech disorders and autism is extremely important, as long as E-PP0154
they provide timely specific medical and pedagogical assistance, Hearing loss and autism spectrum
they are amenable to correction. disorder comorbidity: challenges for
In the structure of medical and psychological-pedagogical assis-
an early diagnosis. case report and
tance to children with autism, there are no standardized methods
based on scientific research that allow examining the speech of literature review
such patients. J.E. Ibáñez Vizoso* , M.R. Pérez Moreno, N. Tur Salamanca, L. Oca
The aim of the study was the development and application of the Bravo, A. Pelaz Antolín, M.V. Costarelli
method “Determination of speech disorders in children with autism Hospital Clínico San Carlos, Instituto de Psiquiatría y Salud Mental,
at the age of 4 to 7 years.” The diagnostic toolkit was constructed Madrid, Spain
on the basis of the diagnostic criteria of ICD-10 for the heading
F84 General developmental disorders, combining the description
Background and aims.– Among deaf or hard of hearing (D/HH)
of speech disorders characteristic of all autism spectrum disorders.
children, Autism Spectrum Disorder (ASD) comorbidity occurs at
Methods.– The method makes possible to detect the presence of
least at similar rates than hearing children. ASD diagnosis can be
speech disorders in general and also to “measure” the severity of
delayed due to some symptoms overlap. There is a lack of validated
these symptoms.
screening and assessment tools for this specific population. This
Results.– The study involved 609 children aged 4 to 7 years: the
complicates early intervention, associated with better outcomes. A
main study group was represented by patients with established
case of a 16 years old male dually diagnosed is described.
diagnosis, children’s autism (F84.0) - 259 people; 1st comparison
Aims.– To discuss the D/HH and ASD comorbidity and its differential
group 161 people - children with specific speech disorders (F80);
diagnosis through a clinical case report and literature review.
The 2nd group of comparison of 189 healthy children.
Methods.– Clinical evaluation of the patient and literature research.
Conclusions.– Exclusion criteria were mental disorders that were
Results.– Case report: 16 years old, male. During the first trimester
not autistic, moderate mental retardation, including autistic dis-
of pregnancy he was transmitted rubella. At age one he was diag-
orders with moderate mental retardation. The obtained values of
nosed with bilateral profound hearing loss, but hearing aids were
psychometric indicators and evidence of the validity of the diag-
not available. He presented an abnormal communication pattern
nostic method gave grounds for using it to assess the severity of
and restricted behaviours and received autism diagnosis at age six.
speech disorders in children with autism, both for research and for
Overlapping symptoms between D/HH and ASD lie mainly on
diagnostic purposes.
communication domain. Differences exist as deafness associates
language delays instead of an atypical development. Less com-
interest statement.
monly, socialization difficulties and repetitive behaviours such
as sterotyped movements also appear in D/HH resembling other
autism symptoms. Several non validated tools have been used
E-PP0153
for autism screening in this population, such as ABC or BISCUIT,
Comparative analysis of the showing a good capability for differentiating D/HH alone or with
effectiveness of methods of the autism.
diagnosis of speech disorders of Conclusions.– Core autism symptoms should not be attributed to
children with autism age 4–7 years D/HH. Collaboration between professionals is mandatory. Early
S. Hreben identification of dual patients is necessary for better outcomes.
Republican Scientific and Practical Center of Otolaryngology, Disclosure of interest.– The authors have not supplied a conflict of
Psychoneurological department for children, Minsk, Belarus interest statement.
E-PP0155 Background and aims.– Stroke affects not only physical but also
Evaluation of hyperprolactinemia and emotional,psychological, cognitive, and social aspects of patients.
its relation with pubertal To evaluate psychiatric morbidity among the patientsof first ever
ischemic stroke.
development in children and Methods.– A cross sectional comparative study was carried outin
adolescents on second-generation the Department of Psychiatry, Sylhet MAG Osmani Medical Col-
anti-psychotics. One year prospective legeHospital, Bangladesh from July 2013 to June 2014. Sixty six
study ischaemic strokepatients of first attack aged above 18 years (case)
L. Ilzarbe1* , D. Ilzarbe2,3,4,5 , E. de la Serna2,5,6 , J. and 66 healthy peoplewithout any kind of stroke (control) match-
Merchán-Naranjo6,7,8,9 , P. Rodríguez-Latorre6,7,8,9 , C. ing age and sex were included. Ischaemic stroke was diagnosed by
Martínez-Cantarero10 , D. Muñoz-Samons6,11 , C. Llach1 , N. Arbelo1 , reviewing history, clinical examinationand accompanying reports
C. Arango6,7,8,9 , J. Castro-Fornieles2,3,5,6 , I. Baeza2,3,5,6 of CT scan of brain. Psychiatric assessment wasdone using General
1 Institute of Neuroscience- Hospital Clinic de Barcelona, Department Health Questionnaire (GHQ12) and positive cases wereevaluated
of Psychiatry and Psychology, Barcelona, Spain; 2 Institute of using mental state examination. A psychiatric disorder wascon-
Neuroscience- Hospital Clinic de Barcelona, Department of Child and firmed by psychiatrist using DSM-5 criteria.
Adolescent Psychiatry and Psychology- 2017SGR881, Barcelona, Results.– The patient of ischaemic stroke and control subjects were
Spain; 3 Universitat de Barcelona, Faculty of Medicine, Barcelona, similar inage (57.6 ± 5.5 versus 57.1 ± 4.5 years; p = 0.130] and sex
Spain; 4 Institute of Psychiatry- Psychology and Neuroscience- King’s (72.7% maleversus 68.2% male; p = 0.567). Psychiatric disorder was
College London, Department of Child and Adolescent Psychiatry, found significantlyhigher in ischaemic stroke group compared to
London, United Kingdom; 5 IDIBAPS, Institut d’Investigacions Biomèdi controls (34.8% versus 13.6%; p = 0.004). Psychiatric disorders were
ques August Pi Sunyer, Barcelona, Spain; 6 CIBERSAM, CIBER of generalized anxiety disorder (13.6%) and major depressive disorder
Mental Health, Madrid, Spain; 7 Universidad Complutense de Madrid, (21.2%) in stroke group; while generalizedanxiety disorder (3.0%)
School of Medicine, Madrid, Spain; 8 Hospital General Universitario and major depressive disorder (10.6%) in controls (p = 0.013).
Gregorio Marañón, Child and Adolescent Psychiatry Department, Conclusions.– Conclusion: Psychiatric disorders are more frequent
Madrid, Spain; 9 IISGM, Instituto de Investigación Sanitaria Gregorio among patients with firstever ischaemic. Therefore attention
Marañón, Madrid, Spain; 10 Hospital Infantil Universitario Niño Jesús, should be paidto the anxiety and depressive symptoms in stroke
Child and Adolescent Psychiatry Department, Madrid, Spain; unit and try to relieve the patient emotional stress and personal
11 Hospital Sant Joan de Déu, Child and Adolescent Psychiatry suffering, which could improve their neurological outcome.
Department, Barcelona, Spain Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– Hyperprolactinemia is a common adverse

effect in patients receiving antipsychotics (AP), specially amongst
females. Data on the influence of pubertal development in hyper- E-Poster Presentation: Child and Adolescent
prolactinemia is scarce. Our aim is to evaluate the effect of sex and Psychiatry - Part III
Tanner stage (TS) in serum prolactine levels in a sample of children
and adolescents on AP.
Methods.– Children or adolescents AP naïve or quasi naïve (<30 days E-PP0157
on AP) were included in a multicentric longitudinal study. Patients
Seeking for social support, self-blame
were on the same single AP during the follow-up. TS and prolactine
levels were measured at baseline, at 3, 6 and 12 months. Multilevel and self-reported psychopathology
mixed-effects linear regression models, where group, baseline pro- symptoms among adolescents
lactine levels and time were included as fixed effect and individual L. Pechnikova, G. Arina, M. Iosifyan*
as random effect. The interaction sex by TS, age and equivalent Moscow State University, Department of Psychology, Moscow, Russia
doses were also added as covariates when achieving significance
level.
Results.– 216 patients were induded. At baseline, patients Background and aims.– The present study investigated how poten-
(age:14.6 ± 3.4 years; 60.2% male) were on risperidone (N = 143), tially modifiable factors – coping strategies – are associated with
olanzapine (N = 37), or quetiapine (N = 36); and 145 had at least depression and anxiety symptoms among adolescents.
one prolactine level determination at follow-up. There were no Methods.– Participants (N = 102, 53 males, from 13 to 15 years old,
differences in the puberal status distribution at baseline (p = .66), Mage = 13.86) reported using various coping strategies (The Bern
but asignificant interaction between sex x TS was found (p = .016), Coping Forms; Heim, Valach, 1996), anxiety and depression symp-
showing that females at higher stage of pubertal development toms (CDI; Kovacs, 2001).
when the AP was firstly introduced presented higher prolactine Results.– Coping strategies explained a significant proportion of
levels compare to males. There was also a signifcant group effect variance in general anxiety (R2 = .18, F(5, 96) = 5.44, p < .001).
(p = .0001), with risperidone group presenting higher levels. Seeking for social support and self-blame were both positively
Conclusions.– Females at higher pubertal development when start- associated with anxiety (b = .28, t = 2.87, p = .005; b = .284, t = 2.53,
ing AP showed an incresed risk of presenting higher prolactine p = .013). Coping strategies also explained a significant proportion
levels during follow-up. Further studies are required to replicate of variance in general depression (R2 = .20, F(5, 96) = 5.99, p < .001).
these findings. Self-blame was positively associated with depression (b = .415,
Disclosure of interest.– The authors have not supplied a conflict of t = 3.73, p < .001).
interest statement. Conclusions.– In line with previous findings, the study confirms that
putting the blame of negative experiences on oneself is related to
reporting anxiety and depression symptoms among adolescents
E-PP0156 (Garnefski et al., 2002). However, contrary to previous findings, the
study found that seeking for social support is positively associated
Psychiatric morbidity among the
with higher reported anxiety symptoms. This result highlights an
patient of first ever ischaemic stroke importance to investigate factors related to inconsistencies in asso-
M. Inam ciations between seeking for social support and anxiety (Velez et al.,
BMDC, Child and Adolescent Psychiatry, Kulaura, Bangladesh
2016). Overall, the study indicated that self-blame and seeking for disorders increased. For example, the incidence of ASD in children
social support are positively associated with self-reported anxiety under 2 years was 0.5:1000 (data 2016), and in children under
and depression symptoms among adolescents. 4 years old it was 1.8:1000. Children at risk (155:1000), have a
Disclosure of interest.– The authors have not supplied a conflict of soft predisposition of mental pathology, they need comprehensive
interest statement. preventive measures to improve mental health.
interest statement.
E-PP0158
Total screening of the risk of
developing mental illness of young E-PP0159
children in primary health care in Language difficulties in childhood
M. Belarbi1 , N. M’Hadhebi1 , L. Jouini1* , I. hadjkacem2
Russia (data 2017) 1 Razi Hospital, Psychiatric A, Manouba, Tunisia; 2 Hedi Cheker
N. Simashkova1 , M. Ivanov1* , G. Kozlovskaya1 , E. Makushkin2 Hospital, Child Psychiatry, Sfax, Tunisia
1 Federal State Budgetary Scientific Institution “Mental Health * Corresponding author.
Research Center”, Department of Child Psychiatry, Moscow, Russia; 2
Federal State Budgetary Institution “National Medical Research Background and aims.– The language code develops harmoniously
Center of Psychiatry and Narcology of V.P. Serbsky” of the Ministry of in a context of necessary conditions: adjusted affective interac-
Health of the Russian Federation, administration, Moscow, Russia tions, bath of language, preserved audition and intelligence, normal
neurological development and harmonious psychic development.
The objective of this study was to identify early language difficulties
Background and aims.– The Ministry of Health of the Russian Fed- in children aged between 3 years and 3 years 9 months and to study
eration introduced the second stage of the pilot project – the total the personal and environmental factors associated with them.
screening of children 18–48 months of the general population. The Methods.– It is a cross-sectional, descriptive and analytical study
screening is focused on early detection of children from the risk with 165 children integrated into kindergartens in the city of
group for the occurrence of mental and behavioral disorders. Sfax (tunisia). The survey was conducted through Claude Chevrie
Methods.– The study was conducted in two levels. Muller’s Language and Behavior Questionnaire (QLC-3.5), trans-
Level I – the survey was conducted by the total screening in pri- lated into Arabic for teachers; and an information sheet for parents.
mary health care facilities in the nine largest regions of Russia. Results.– 13.4% of children have probable or certain language and
Level II – consultation by a psychiatrist (clinical diagnosis of ICD- motor difficulties. The prevalence of expressive and / or compre-
10). hensive language difficulties is 16.4%. The prevalence of motor /
Results.– In 2017, 329424 parents of children aged 18–48 months attention difficulties and behavioral difficulties associated with lan-
of life were questioned. According to preliminary data, the risk guage difficulties were 59.3% and 48.1%, respectively. Among the
group for the occurrence of psychopathology was 51325 children factors correlated with expressive and / or comprehensive lan-
(155:1000). This condition can last for several years and, over time, guage difficulties were : premature delivery, neonatal resuscitation,
become either a disease or practical health. Some children at risk neonatal hospitalization, the presence of personal or family history
of mental illness were consulted by a psychiatrist (23,158 cases) of delayed oral language; and environmental factors such as low
on a voluntary basis. In 3585 children (11:1000), clinical disorders socio-economic status, mother’s low level of education, postnatal
qualified by ICD-10 were revealed. The distribution of patients by depression, the undesirability of pregnancy, the presence of family
nosological groups is given in table 1. problems, and the poverty of language stimulation.
Table 1. The distribution of mental and behavioural disorders in Conclusions.– The results of this study confirm the high prevalence
children of 1.5–4 age in Russia (data 2017) of language and behavioral difficulties early in life, and suggest
the entanglement of environmental and biological factors in the
genesis of these difficulties.
interest statement.
E-PP0160
Polyvictimization and
psychopathology in a sample of
abused children in Greece
A. Kanellopoulos1* , X. Antoniou2 , G. Tzouvelas2 , M.
Chondrokouki2 , G. Nikolaidis2
1 Gender Dysphoria Care Center- Center for Adolescent Medicine,
First Department of Pediatrics- Athens University Medical School-

Aghia Sophia Children’s Hospital, Athens, Greece; 2 The Smile of the
Child, Day Care Center “House of the Child”, Athens, Greece
Background and aims.– The “House of the Child” (HoC) is a ther-

apeutic center operated by the NGO “The Smile of the Child” in
Greece which is providing comprehensive long-term treatment to
child abuse and neglect victims. The HoC throughout its 3 years
of operation has provided services by specialties such as child and
adolescent psychiatry, clinical psychology, social work, speech and
Conclusions.– As the study showed, with an increase in the age language and occupational therapy and pedagogy to 455 children
coverage of children in the general population, the risk group victims of abuse or neglect currently either living in the community
increased, and the detection of clinically pronounced mental or in residential and alternative care settings.
Methods.– Children which have survived child abuse or neglect E-PP0162

were referred to the HoC for various psychopathological symptoms. Cognition in children with attention
In a selected sample of these children receiving therapy currently
deficit hyperactivity disorder before-
living in residential care a study was conducted by delivering the
Juvenile Victimization Questionnaire (Finkelhor, Hamby, Ormrod,
and after methylphenidate treatment
& Turner, 2005) and the Child Behavior Checklist for ages between N. Khachapuridze* , S. Bakhtadze, N. Geladze
6–18 (Achenbach, Dumenci, & Rescorla, 2001) and a statistical test Tbilisi State Medical University, Paediatric Neurology, Tbilisi, Georgia
was run for checking correlation between polyvictimization and
certain features of psychopathology. Background and aims.– Attention Deficit Hyperactivity Disorder
Results.– Analysis of results showed that polyvictimization had a (ADHD) is one of the commonest condition affected approxi-
moderate positive correlation with Achenbach’s items impulsivity mately 5% of children and adolescents. Main treatment is cognitive
and disobedience, cruelty to others as well as preferring rela- behavioral therapy but in some cases drug management with
tionships with younger age children; while it was also correlated Methylphenidate also can be considered which is known to
negatively with exhibiting ticks, speaking too much and reporting improve behavioral profile and decrease restlessness and impul-
wired ideas. sivity.
Conclusions.– Our results highlight the importance of studying The aim of our study was to assess the impact of methylphenidate
these highly victimized samples, since it is not only the presence of on cognitive profile of ADHD children by assessing the most
multiple victimization experiences but the degree of polyvictim- valid objective method event related potentials (ERPs) parameters
ization that contributes to the severity of rule-breaking behavior before and after treatment.
and aggressive behavior. Methods.– We have examined 44 children with ADHD (28 boys,
Disclosure of interest.– The authors have not supplied a conflict of 16 girls) aged 9–12 years. All of them were diagnosed as ADHD of
interest statement. combined forms presenting with both inattentiveness and restless-
ness. The diagnosis was done by DSM-V criteria. IQ was measured
by Wechsler Scale. All children with IQ lower than 80 were
E-PP0161
excluded from the study. ERP was registered by using of oddball
Mental disorders and alexithymia in paradigm. The latency of ERP (P300) was assessed before- and after
children with sensory and mental Methylphenidate intake. Drug dosage was 1 mg/kg. Statistical anal-
impairments ysis was performed by ANOVA.
I. Karaush* , I. Kupriyanova Results.– P300 latency before Methylphenidate treatment ranged
Mental Health Research Institute SB RAMSci, Department of border from 350–400 msc (mean 370msc). Amplitude was between
States, Tomsk, Russia 50–90 mV (mean 70 mv). The latency decreased within 20 days
* Corresponding author. from treatment ranging from 300–330 msc (mean 310 msc) while
amplitude stayed the same 50–90 mV (mean 70 mv) after treat-
Background and aims.– ment. Reduction of latency was statistically significant (p < .0001).
Aims.– The detection of alexithymia and its relationship with Conclusions.– Methylphenidate can affect not only on behavioral
mental pathology in children with severe hearing and vision disorders in ADHD children but it can significantly improve cogni-
impairments. tive profile by decreasing the latency of P300 which correlates with
Methods.– Material: 368 students of specialized (correctional) attention parameters.
schools aged 7–18 were examined. Disclosure of interest.– The authors have not supplied a conflict of
Methods: clinical, alexithymia scale TAS-20, adapted for adoles- interest statement.
cents with disorders of psychological development, statictical.
Results.– There was a high prevalence of mental disorders (79.1%).
At the hearing and deaf students more frequent were mixed spe- E-PP0163
cific developmental disorders (64%), mental retardation (21,5%), Dynamics of arbitrary memory in
speech disorders (94,6%); in children with visual impairment –
children and adolescents with
organic disorders (19%), hyperkinetic disorder (13%). Combined
mental pathology was detected in 29.3%, significantly more often schizophrenia on treatment process
(p = 0.002) – in children with hearing impairment. Three adoles- A. Khromov1* , N. Zvereva2
1 Moscow State University of Psychology & Education MSUPE-,
cents (271 student 10–18 years) groups were selected – «normal»,
«risk alexithymia» and «alexithymia». It was noted the prevalence Department of Neuro- & Pathopsychology of Development, Moscow,
of the «alexithymia» group among children with hearing impair- Russia; 2 Mental Health Research Center MSUPE, Department of
ments (42,33%; p = 0.012). The main discriminating feature dividing Clinical Psychology, Moscow, Russia
the selected groups is the presence of a psychiatric diagnosis. Other
discriminatory signs were: the type of upbringing, the violation of Background and aims.–
adaptation to kindergarten, levels of anxiety and psychotraumatic Introduction.– Memory as cognitive function is affected in young
factor of «awareness of physical defect». patients with schizophrenia. Investigation of impairment of cog-
Conclusions.– The developed alexithymia scale allows to identify nitive functioning and its developmental ability in such patients
pupils who need preventive or psychotherapeutic, psycho- during pharmacological treatment demands follow-up assessment.
correction and psycho-educational measures. The main preventive Objectives.– To assess dynamics of arbitrary memory in longitudi-
the formation of alexithymic traits directions in a child with a sen- nal study of children and adolescents with schizophrenia between
sory defect are: early detection and correction of mental disorders; two points (soon after hospitalization and before discharge) and
the presence of family «models» of emotional reaction, empathy its relation to clinical factors (diagnosis, age of onset, duration of
and expression of emotions; correction of pathological upbringing illness).
types; the formation of emotional vocabulary; emotional support Methods.– 71 patients (53 males) with schizophrenia spectrum
at all periods of development. disorder (F21, F20.8) were included to study. Mean age was
Disclosure of interest.– The authors have not supplied a conflict of 12.3 ± 2.8 years. Patients were assessed twice during hospitaliza-
interest statement. tion in child psychiatric clinic of MHRC: soon after admission and
before discharge. Average interval between these points was 33.2
days. Memory was assessed with experimental pathopsychological E-PP0165

methods (10 words, Paired Associations). Examining factors associated with
Results.– Paired comparison for all patients didn’t reveal significant
problematic internet use among
changes in memory level, neither as groups divided by age or sex
did. Level of deferred memory in patients with F20.8 significantly
youth – a cross-sectional study
decreased and significantly increased in patients with F21. There H. Kiss1* , B. Pikó2
1 University of Szeged, Doctoral School of Education, Szeged,
was difference between patients with F20.8 and F21 in relation of
efficacy of memory with duration of interval: efficacy of memory in Hungary; 2 University of Szeged, Department of Behavioral Sciences,
patients with F20.8 was lower in second point if duration of treat- Szeged, Hungary
ment exceed 30 days and conversely in patients with F21. Relation
with duration of illness was revealed. Background and aims.– Tools of modern technology especially the
Conclusions.– Clinical factors (diagnosis, treatment duration) can Internet has become essential part of the life of new generations
moderate the level of memory in children and adolescents with during the past years. Besides many benefits (e.g., immediacy,
schizophrenia. Recommendations for psychiatrist are developed. anonymity, limitlessness), there are serious social and health
Disclosure of interest.– The authors have not supplied a conflict of consequences, such as behavioral addictions, sleeping disorders,
interest statement. physical symptoms like visual impairment or depression. We aimed
to detect psychological factors that can be present in the back-
ground of problematic Internet use (PIU) in a sample of Hungarian
E-PP0164
youth. In recognition of these data, we would like to develop an
Comparison of temperament and effective prevention program for young people.
character profiles for children with Methods.– Our sample consisted of 249 youth (mean age: 22.04
ADHD alone and children with ADHD years; 62.2% females). Data were collected via Internet using a
with tic disorder self-reported online questionnaire. It included demographic data,
D.H. Kim* , N.R. Kang, Y.S. Kwack questions about online time, and the Hungarian versions of seven
Jeju National University Hospital, Deparmet of Psychiatry, Jujusi, scales about PIU, boredom, flow, resilience, self-control, self-
Republic of Korea esteem and sensation seeking. Regression analysis was conducted
* Corresponding author. to explain the nature of the correlations between PIU and the above-
mentioned factors.
Background and aims.– ADHD is accompanied by various psychiatric Results.– We found that 6% of the participants are problematic
disorders. Tic disorder, in particular, is commonly comorbid with users. Linear regression showed that the hours spending online
ADHD. on weekends (␤ = 1.343, p < .001), self-control (␤ = −.344, p < .001),
There is no research about whether ADHD with tic disorder that resilience (␤ = −.285, p < .001), boredom (␤ = .080, p < .001) and age
temperamental features that differ from the ADHD. (␤ = −.340, p < .001) are important factors in the background of PIU,
This research aimed to identify temperament and character pro- while gender does not play a role.
files for children with ADHD according to tic disorder by comparing Conclusions.– Our results confirm previous findings that intensive
them with a healthy control group. use of Internet may contribute to PIU. Strengthening and devel-
Methods.– oping psychological skills like self-control, resilience and finding
Subject.– Forty children with ADHD without tic disorder and forty exciting activities seem to be cardinal points in prevention.
children with ADHD with tic disorder were selected as subjects. Disclosure of interest.– The authors have not supplied a conflict of
The diagnoses of ADHD and tic disorder were made accord- interest statement.
ing to DSM-IV, and confirmed by parent interviews using the
Korean version of Kiddie-Schedule for Affective Disorder and
Schizophrenia–Present and Lifetime Version.
Forty healthy children were recruited for control group. E-Poster Presentation: Child and Adolescent
To exclude psychiatric disorders, control group parents were con- Psychiatry - Part IV
ducted to Diagnostic Interview Schedule for Children Version IV.
The total subjects (N = 120, mean age 8.57 ± 1.71 years, 102 male)
consisted of 40 age- and gender- matched children in each group. E-PP0166
Results.– The two ADHD groups showed higher novelty seeking Prevalence of suicide behaviours in
and low persistence, self-directedness and cooperativeness than
the control group. The ADHD alone group had lower scores for
adolescents with autism
V. Muñoz Martinez* , B. Mata-Saenz, L. Asensio-Aguerri, E.
persistence and self-directedness than the other two groups.
Segura-Escobar, L. Beato-Fernández
Temperament and character profiles were useful for discriminating
Hospital General Universitario de Ciudad Real, Psychiatry, Ciudad
ADHD from the control group.
Real, Spain
Conclusions.– Differences in temperament and character in ADHD * Corresponding author.
children were present according to comorbid tic disorders.
JTCI’s discriminating power for ADHD alone and ADHD with tic dis- Background and aims.– A systematic review of the literature on the
order was relatively lower than that of the combined ADHD group prevalence of suicidal phenomena in adolescents found that the
and the control group. mean proportion of adolescents reporting having attempted sui-
Disclosure of interest.– The authors have not supplied a conflict of cide was 9.7%, whilst 29.9% of adolescents said they had thought
interest statement. about suicide at some point [2,3]. The aim of this study is to ana-
lyze the clinical features in patients with autism spectrum Disorder
who were admitted in our inpatient unit because suicidal attempts
and ideation.
Methods.– An observational, descriptive, retrospective study was
conducted. 15 patients were recruited during the period of four
years (2014- 2018). The age average was 16,2 years old. The diag-
noses were made with the ADOS-2.
Results.– The majority of participants were male (80,1%) and the Interdisciplinary Center Psychopathology and Emotion Regulation-
63,9% took psychiatric medication (73,4% antipsychotics, 15,2% Department of Developmental Psychology, Groningen, The
antidepressants and the 11,4% benzodiacepines). The 8,2% of the Netherlands
patients had two admission or more in our unit. The 35,2% of the * Corresponding author.
admission was for self harm and the 15,7% the admission were only
for suicidal ideation. The 0,7% had relatives who committed suicide Background and aims.– Sleep problems and anxiety symptoms
and 25,6% had a close person who had suicidal ideation, most of considerably increase during adolescence. Previous studies found
them were friends. Most patients with suicidal behavior or ideation a bidirectional association between sleep problems and anxiety
also had a comorbid diagnosis of depression and anxiety. The 72,9% symptoms, but did not distinguish differences between persons
of the diagnosis were high functioning Autism. from differences within persons. This could have led to erroneous
Conclusions.– Result suggest than suicidal ideation is common in conclusions regarding underlying causal mechanisms. We aimed to
adolescent with and ASD. The main principal feature was anxi- investigate the bidirectional association between sleep problems
ety and depression and difficulties in interpersonal relationships. and anxiety symptoms during adolescence and young adulthood
Most of this depression and anxiety symptoms were related with while differentiating between between-person effects and within-
interpersonal difficulties especially in teenagers. person effects.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– We used data from TRacking Adolescents’ Individual
interest statement. Lives Survey, a prospective cohort study including six waves of data
spanning 15 years. Participants included 2230 Dutch young adoles-
cents (mean age at baseline 11.1 years; SD 0.5,), who were assessed
E-PP0167 every 2 to 3 years up until young adulthood (mean age 25.6 years,
Admissions analysis during a year in SD 0.6). Sleep problems and anxiety symptoms were measured
by self-report questionnaires. Bidirectional temporal associations
an adolescent and childhood unit between sleep and anxiety were tested using a Random Intercept
V. Muñoz Martinez* , B. Mata-Saenz, L. Asensio-Aguerri, C.
Cross-Lagged Panel Model.
Rodriguez Gómez-Carreño, L. Beato-Fernández
Results.– Study participants who reported sleep problems were sig-
Hospital General Universitario de Ciudad Real, Psychiatry, Ciudad
nificantly more likely to report elevated anxiety than those who did
Real, Spain
* Corresponding author. not report sleep problems (␤ = 0.58, p < .001). Also at the within-
person level, sleep problems and anxiety were cross-sectionally
Background and aims.– A wide variety of studies from different associated at all waves (␤ = 0.014–0.018, p < .001). In addition, poor
countries have emphasised the increasing number of childhood and sleep predicted greater anxiety symptoms after 2 years at the
adolescent emergencies between the years. The principal diagnoses within-person level at some assessments waves, but the reverse
are: Disruptive Behaviour Disorder, Anxiety Disorder and Adaptive association was not statistically significant.
disorders. Conclusions.– These findings tentatively suggest that adolescent
Methods.– An observational, descriptive, retrospective study was sleep problems may precede anxiety symptoms, and so that anxiety
conducted. 243 patients were recruited during the period of one might be prevented by alleviating sleep problems.
year (2017). All patients were under 18 years of age. Disclosure of interest.– The authors have not supplied a conflict of
Results.– 56,8% of the 243 patients were women, the age average interest statement.
was 25,08 (standard deviation, SD, 1,62). The patients were admit-
ted for 14,62 days (SD 10,82). The 33,3% of the patients came from
E-PP0169
our area despite that 34,6% came from other areas. The rates of
re-admission were 34,6%. At the moment of admission, the more Learned resourcefulness, perceived
frequent diagnoses were: Disruptive Behaviour Disorder (32,5%), stress levels and related factors in
Suicidal Ideation (18,9%). After the admission, the discharge diag- high school students
nosis was: Depressive Disorder (32,5%) and Disruptive Behaviour F. Yıldız1 , F. Oflaz2*
Disorder (17,3%). Both diagnoses differ in 58% of the patients. 1 Şişli Eftal Vocational and Technical High School, Nursing
Conclusions.– The rates of admissions per sex and diagnosis and the Department, Istanbul, Turkey; 2 Koç University, School of Nursing,
average age scores were similar compared to previous studies. The Istanbul, Turkey
lack of external and ambulatory resources will be one of the rea- * Corresponding author.
sons because children and adolescents with Disruptive Behaviour
Diagnosis have more admissions in comparison with other diagno- Background and aims.– In order to solve the identity crisis experi-
sis. Improving social resources and other sanitary resources such as enced by adolescents, it is important to recognize the sources of
Child and Adolescent Child Day Hospital, will change this pattern stress, the resources of coping, social support and self-regulation.
and admissions will decrease. Moreover, intensive therapy with Aim.– The aim of this study was to investigate the learned resource-
these patients will also decrease the number of admissions due to fulness levels and its relationship with perceived stress and some
suicidal ideation because both diagnoses have high comorbidity. socio-demographic factors in high school students.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– This descriptive and correlational study was conducted
interest statement. in a Anadolu High School in Istanbul in 2016–2017. Study sam-
ple consisted of 343 females and 89 male students (total 434) who
were attending to the School that year. Data were collected by using
E-PP0168 “Personal Information Form”, “Rosenbaum Learned Resourceful-
The bidirectional association between ness Scale” and “Perceived Stress Scale”. ANOVA, t-tests, Pearson
sleep problems and anxiety symptoms correlation and linear regression analysis were performed to com-
pare the groups and variables.
in adolescents: a trails report Results.– There was a weak but statistically significant corre-
A. Narmandakh1* , A. M. Roest2 , P. De Jonge2 , O. J. Albertine1
1 lation between the student’s learned resourcefulness (LR) and
University Medical Center of Groningen- University of Groningen,
perceived stress levels (p < 0.05). There was no significant rela-
Interdisciplinary Center Psychopathology and Emotion Regulation-
tionship between learned resourcefulness scores and age, gender
Department of Psychiatry, Groningen, The Netherlands; 2 University
of students and parents related factors. However the 9th grade
Medical Center of Groningen- University of Groningen,
students have had significantly higher LR scores and lower stress
scores. There was significant difference between perceived stress not resulting from psychatric, neurologic or other medical condi-
levels and age, gender and grades of students. While learned tions such as hearing impairment, mental retardation, pervasive
resourcefulness scores increased, stress level, irritability and self developmental disorders or autism. It is generally characterized
efficiency scores were decreased. with significant discrepancy between the child’s language develop-
Conclusions.– Age, grades and parents features had no effect on the ment and general cognitive function. It is a common developmental
learned resourcefulness of students, however there was a strong disorder with a prevalence between 2.6–16% in preschool chil-
negative relationship between LR and perceived stress. Thus, try- dren. Environmental, demographic and socio-economic factors
ing to increase the LR level may help to prevent higher stress in have been found to be among factors associated with the devel-
adolescents. opment of specific language impairment. The role of exposure to
Disclosure of interest.– The authors have not supplied a conflict of a multilingual home environment in specific language impairment
interest statement. remains controversial, as previous reports have yielded conflicting
results.
Methods.– Herein we aimed to present four cases diagnosed with
E-PP0170 specific language impairment in order to discuss the effect of mul-
Sedation – an uncommon side effect tilingual home environment on this condition as well as different
of stimulant based ADHD treatment: a confounding factors. Cases were between ages 2–5 years at the time
of admission, all were male, living currently in multilingual home
case report
environment where at least three languages were spoken. Detailed
C. Ong* , A. Pumariega
psychiatric examination have been done by a child and adolescent
University of Florida, Psychiatry, Gainesville, USA
* Corresponding author. psychiatrist, other clinical branch consultations with relevant lab-
oratory and imaging tests have been performed in order to exclude
Background and aims.– Stimulant medications are first-line phar- other medical conditions.
macological treatments for attention deficient and hyperactivity Results.– Any psychiatric or other medical condition explaning lan-
disorder (ADHD). Common side effects of stimulants include guage impairment have been detected in patients, concluding the
headache, insomnia, weight loss, and irritability. We report the diagnosis as specific language impairment.
case of a 12-year-old boy with a history of ADHD who exhibits Conclusions.– Multilingual home environment might lead to spe-
the uncommon side effect of sedation on multiple stimulant based cific language impairment in children, emphasizing the importance
treatments. of detailed investigation of family characteristics and home envi-
Methods.– Case report of a child referred to our psychiatry clinic. A ronment in these cases.
PubMed literature review using the terms “stimulant,” “sedation,” Disclosure of interest.– The authors have not supplied a conflict of
and “drowsiness” was conducted. interest statement.
Results.– A 12-year-old boy was evaluated for management
of ADHD. He was previously started on low dose dextroam-
phetamine/amphetamine which helped with inattention, however E-PP0172
caused significant sedation. He was then trialed on low dose lis- Hospital outcomes in american teens
dexamfetamine that also reduced inattention, but again caused with ADHD in states with recreational
drowsiness. We hypothesized that he was an ultra-slow metab- marijuana laws
olizer who experienced supra-therapeutic levels of stimulants R. Patel1* , M. Rathod2 , A. Sadolikar3 , P. Mainali4 , Z. Mansuri5
resulting in sedation. He then tried low dose methylphenidate 1 Griffin Memorial Hospital, Psychiatry, Norman, USA; 2 Washington
which improved inattentive symptoms, however still caused seda- DC VAMC, Psychiatry, Washington DC, USA; 3 Florida International
tion (albeit not as severe). Pharmacogenetic testing was ordered to University, Internal Medicine, Miami, USA; 4 Zucker Hillside Hospital,
confirm our ultra-slow metabolizer hypothesis, but results showed Psychiatry, Glen Oaks, USA; 5 Texas Tech University Health Science
that he had reduced activity at the catechol-o-methyl transferase Center, Psychiatry, Midland, USA
(COMT) genotype and reduced response at the adrenergic alpha- * Corresponding author.
2A receptor gene (ADRA2A), both of which suggest a reduced
response to amphetamine based treatments. PubMed literature Background and aims.– To determine the differences in inpatient
review shows no known case reports of stimulants causing sedation outcomes in young cannabis users (CU) with ADHD between states
or drowsiness. with versus without recreational marijuana laws (RML).
Conclusions.– Sedation is a rare side effect of ADHD treatment which Methods.– We used the nationwide inpatient sample (NIS) from
is usually caused by supra-therapeutic stimulant blood levels. We 2012–2014. We identified adolescents (12–18 years) with ADHD
present the first known case report of stimulant induced sedation and cannabis use disorder as primary and secondary diagnosis,
not caused by supra-therapeutic blood levels as supported by phar- respectively, using ICD–9 diagnosis codes. They were divided into
macogenetic testing. groups- states with RML and non-RML Pearson’s chi square test
Disclosure of interest.– The authors have not supplied a conflict of was used for categorical variables and logistic regression model to
interest statement. generate odds ratio (OR).
Results.– All CU in RML group were admitted for ADHD on emer-
gency basis and they had 7-fold odds of weekend admission (95%
E-PP0171 CI 2.207–22.378, P < .001). The mean inpatient stay of CU in RML
Specific language impairment due to was lower (1.7 days vs 6.2 days, P = .012) compared to non-RML.
multilingual home environment And, inpatient cost in RML was $26,898 compared to $30,034 in
E. Akaydin1 , U. Ozer2* , A.E. Tufan3 non-RML group (P = .012). The median stay and charge for the sam-
1 Acibadem University School of Medicine, Medical Student, Istanbul, ple population was 5 days and $9,160 respectively. Though lower
Turkey; 2 Acibadem University School of Medicine, Psychiatry, proportion of CU in RML had hospitalization >5 days (23.8% vs 38%,
Istanbul, Turkey; 3 Acibadem University School of Medicine, Child P < .001), but more of these CU had inpatient charges >$9,160 (76.2%
and Adolescent Psychiatry, Istanbul, Turkey vs 48.7%, P = .013).
* Corresponding author. Conclusions.– CU have higher chances of inpatient admission for
ADHD during weekends through emergency department. Their
Background and aims.– Specific language impairment is defined hospitalization stay is shorter but are more likely for overall inpa-
as impaired language development expected for the child’s age,
tient cost above the median, may be due to increased utilization of thoughts about the need to resort to network activity (observed in
hospital resources. 70% of respondents 18 months before seeking medical care) and the
Disclosure of interest.– The authors have not supplied a conflict of choice of an electronic device in the presence of no less attractive
interest statement. alternative (observed in 50% of respondents 18 months before seek-
ing medical care) (phenomena of pathological attraction). Also, the
use of the scale allowed to identify signs of aggravation of symp-
E-PP0173 toms observed 15–16 months before the formation of a complete
Are American teens at a higher risk of clinical picture of the dependence that causes the appeal for help
suicidality in the states with legalized – stretching the child’s time spent at the computer (up to 70% of
respondents) and expressed “processing” of self-limited time (60%
recreational marijuana?
of respondents)(phenomena of loss of control).
R. Patel1* , M. Solanki2 , A. Sadolikar3 , P. Mainali4 , Z. Mansuri5
1 Conclusions.– The identification of these phenomena in the preclin-
Griffin Memorial Hospital, Psychiatry, Norman, USA; 2 Washington
ical stages of the addiction makes it possible to carry out prevention
DC VAMC, Psychiatry, Washington, USA; 3 Florida International
in time and greatly facilitates therapy, allows limiting psychother-
University, Internal Medicine, Miami, USA; 4 Zucker Hillside Hospital,
apeutic intervention
Psychiatry, Glen Oaks, USA; 5 Texas Tech University Health Science
Center, Psychiatry, Midland, USA
Background and aims.– To determine the risk of morbidity and suici-

dality in cannabis users (CU) with ADHD between states with versus E-PP0175
without recreational marijuana laws (RML). Family anxiety, attachment and
Methods.– We used the nationwide inpatient sample (NIS) from neuroendocrine biomarkers in obese
2012–2014. We identified adolescents (12–18 years) with ADHD children
and cannabis use disorder as primary and secondary diagnosis, I. Pinto1* , S. Wilkinson2 , D. Virella3 , M. Alves3 , C. Calhau4 , R.
respectively, using ICD–9 diagnosis codes. They were divided into Coelho5
groups- states with RML and non-RML Pearson’s chi square test 1 Hospital Beatriz Angelo, Psychiatry, Loures, Portugal; 2 Akershus
was used for categorical variables and logistic regression model to University Hospital, Child and Adolescent Psychiatry, Lørenskog,
generate odds ratio (OR). Norway; 3 Centro Hospitalar de Lisboa Central, Research Center,
Results.– Majority of the CU admitted for ADHD had moderate mor- Lisboa, Portugal; 4 NOVA Medical School, Nutrition and Metabolism,
bidity (52.4% in RML and 53.4% non-RML), but non CU in RML Lisboa, Portugal; 5 Faculty of Medicine- University of Porto,
had severe morbidity compared to that seen in 6.7% CU in non- Neurosciences and Mental Health., Porto, Portugal
RML states (P = .04). Despite of this CU in RML had higher odds * Corresponding author.
of longer hospitalization (OR = 2.53, 95% CI .696–9.219, P = .016). A
higher proportion of CU were suicidal in states with RML (52.4% vs Background and aims.– The quality of the relationship between a
18.3%, P < .001). So, CU in these states 4.1-folds more suicidal than child and his primary caregiver affects the child’s emotion reg-
those in non-RML states (95% CI 1.216–13.912, P = .023). 23.8% CU ulation and stress response. Extreme stress responses associate
in RML states were more likely to be discharged to skilled nursing with dysregulation of physiologic systems involved in emotion
facility compared to 3.4% CU in non-RML states (OR = 25.41, 95%CI and energy balance, which could be associated with emotional
2.971–217.355, P = .003). and/or behavioural disorders, and obesity. If research confirms
Conclusions.– Adolescents with ADHD and abusing cannabis in associations between quality of mothering and neuroendocrine
states with RML are more suicidal. They also require acute inpatient biomarkers, then mental health and obesity, prevention inter-
care and are more likely of adverse discharge after management. ventions might emphasize on the quality of maternal–child
This is a public health concern and requires amendment in RML in relationships.
the US. Aims.– Identify associations between anxiety, depression and neu-
Disclosure of interest.– The authors have not supplied a conflict of roendocrine biomarkers in obese children, exploring attachment
interest statement. and family functioning as intermediary variables.
Methods.– A convenience sample of 104 obese children, mean age
10.9 years, was recruited at a childhood obesity clinic of a tertiary
E-PP0174 hospital in Lisbon. Neuroendocrine biomarkers were measured.
The phenomenological diagnostic Symptoms of anxiety and depression, attachment strategies and
scale of addiction from a personal family functioning were assessed.
Results.– A significant, negative correlation (rs = −0.78; p = 0.003)
computer, the internet and mobile
between cortisol in obese girls and their mothers’ anxiety symp-
devices toms was found, limited to high functioning families. Obese boys
L. Perezhogin scored significantly higher than girls on mother-reported internal-
National Medical Research Center for Psychiatry and Narcology, Child izing symptoms but not on self-report. Type A, avoidant attachment
and Adolescent Social Psychiatry, Moscow, Russia strategies, had significant negative association with cortisol levels
Background and aims.– Dependence on a personal computer, Inter- (␤-estimate = −0.015(95%CI: −0.028 to −0.001; p = 0.036).
net and mobile devices has become one of the most urgent Conclusions.– These findings suggest that processes involved in
problems of modern addictology in recent years. development of the Type A attachment strategy may affect the reg-
Methods.– The empirical base of the study consisted of 220 minors ulatory mechanisms of the stress axis. In obese children, different
aged 9 to 17 years (133 boys and 97 girls) who applied for attachment strategies are associated with diverse metabolic pro-
psychotherapeutic help in 2013–2017 and found signs of Internet- files. Family functioning, parental mental state and child’s gender,
dependent behavior. The analysis of their clinical data allowed should be considered when investigating neuroendocrine biomark-
to develop a “Scale of evaluation of dependence on the personal ers in obese children associated with anxiety and depression in the
computer, the Internet and mobile devices providing access to it” family.
(phenomenological questionnaire). Disclosure of interest.– The authors have not supplied a conflict of
Results.– The use of the scale makes it possible to identify the interest statement.
first signs of the addiction at an early stage. These are persistent
E-PP0176 with autism than control, but there were no significant differences
Negative symptoms in children and in the frequencies either of the 102T/C genotype or His452Tyr
adolescents at clinical high risk for genotype between the two groups. was a significant increase of
homozygote A allele of the -1438A/G and CC genotype of the 102T/C
psychosis: a factorial analysis study polymorphism in ASD children with GID.
M. Pontillo1* , A. Vignapiano2 , A. Mucci2 , S. Vicaristefano.
Conclusions.– This study supports the possible involvement of the
vicari@opbg.net1 , S. Galderisisilvana.galderisi@gmail.com2
1 Paediatric Hospital Bambino Gesù, Neuroscience, Rome, Italy; 2
5-HT2A receptor in the development of ASD and associated GID.
University of Campania Luigi Vanvitelli, Psychiatry, Naples, Italy
interest statement.
Background and aims.– Recent years have seen an increase in clin-

E-PP0178
ical efforts towards detection and intervention in the individuals
at Clinical High Risk (CHR) for psychosis. In CHR adults the preva- Catechol-O-methyltransferase
lence of negative symptoms is high of which social isolation and Val158Met polymorphism and
reduced motivation are most frequently reported. There are no hyperactivity symptoms in egyptian
studies in which the prevalence and above all the factorial struc- children with autism spectrum
ture of the negative symptoms have been examined in children and
adolescents CHR.
disorder
N. Raafat1* , R. karam2 , N. Rezk2 , H. Abdelrahman3 , T. Hassan3 , D.
The aims of this study are twofold: the first was to determine the
Mohamed4 , H. Hashem5
prevalence of negative symptoms and explore their factor structure 1 Assistant Prof, Psychiatry, Zagazig, Egypt; 2 Assistant Prof,
as measured by the Structured Interview for Prodromal Syndromes
Biochemistry, Zagazig, Egypt; 3 Prof, Pediatric, Zagazig, Egypt; 4
(SIPS/SOPS); the second was to evaluate the correlations between
Assistant Prof, Pediatric, Zagazig, Egypt; 5 Prof, Psychiatry, Zagazig,
factors extracted from negative items and functioning.
Egypt
Methods.– 71 CHR, aged between 9–17 years, were included in the * Corresponding author.
study. All participants were assessed with SIPS/SOPS.
Results.– All participants (100%) had a score at moderate severity or Background and aims.– Catechol-O-methyltransferase (COMT)
above on at least one negative symptom of SIPS/SOPS. Social Anhe- plays an important role in the catabolism of brain dopamine and
donia/ Withdrawal was the most frequent negative symptom in our norepinephrine, which have been implicated in the pathogenesis
sample. The exploratory principal factor analysis (PCA) indicated of Autism spectrum disorder (ASD) as well as in other neuropsy-
a two-factor solution explaining 69.42% of total variance in the chatric disorders. We aimed to investigate the association of COMT
whole sample. Two factors were labeled “Expressive Deficit” and Val158Met gene polymorphism with ASD and to examine the influ-
“Anhedonia-Avolition”. In addition, “Anhedonia -Avolition” factor ence of such genotypes on hyperactivity symptoms in ASD patients.
was associated with functioning score. Methods.– Eighty ASD patients (mean age 9 ± 1.9 years) and
Conclusions.– This is the first study of prevalence and factorial 100 control children (mean age 8.9 ± 1.9 years) were examined.
structure of negative symptoms in children and adolescents CHR. COMT Val58Met polymorphism was genotyped using Tetra-primer
Negative symptoms are frequent in this clinical population and ARMS-PCR method. The clinical diagnosis of ASD and ADHD were
need specific treatments. Our data replicate the actual model of confirmed according to the DSM-IV criteria for research.
negative symptoms in schizophrenia and CHR adult populations. Results.– We found no significant difference in genotypes or alle-
Disclosure of interest.– The authors have not supplied a conflict of les’ frequencies of COMT Val158Met polymorphism between ASD
interest statement. patients and control group. There was a significant association
between COMT (Val/Val) genotype and both increasing CARS
(p = 0.001) and hyperactivity scores (p = 0.006). Regarding Conner’s
E-PP0177
Score, the DSM-IV hyperactive impulsive were significantly higher
Association of 5-HT2A receptor gene in Val/Val genotype than both Met/Val and Met/Met genotypes
polymorphisms with gastrointestinal (p = 0.03).
disorders in egyptian children with Conclusions.– Our data suggested an association between COMT
Val58Met polymorphism and hyperactivity symptoms in Egyptian
autistic disorder
children with ASD
N. Raafat1* , H. Abdelrahman2 , A. Alghobashi2 , L. Sherif3 , H.
Abouhashim4 , M. Abdelsalam2
1 Assistant Prof, Psychiatry, Zagazig, Egypt; 2 Assistant Prof, Pediatric, interest statement.
Zagazig, Egypt; 3 Prof, Pediatric, Zagazig, Egypt; 4 Prof, Psychiatry,
Zagazig, Egypt
Interleukin 8 (IL-8) and tumor
Background and aims.– Gastrointestinal disturbances (GID) are fre- necrosis factor alpha (TNF-alpha)
quently reported in children with autism spectrum disorders (ASD). serum levels in adolescent and young
Recently, mounting evidence suggests that there may be a genetic
link for autism with gastrointestinal disturbances. We aimed to
adults with mood disorders
A. Rajewska-Rager1* , M. Skibinska1 , M. Dmitrzak-Weglarz1 , P.
investigate whether there were any association between the -
Kapelski1 , N. Lepczynska2 , P. Sibilski2 , J. Pawlak1 , J.
1438A/G, 102T/C and His452Tyr polymorphisms of the serotonin
Twarowska-Hauser1
2A receptor gene (5-HT2A) in Egyptian children with ASD and GID. 1 University of Medical Sciences, Psychiatric Genetics Unit, Poznan,
Methods.– Eighty children with autistic disorder and 100 healthy
Poland; 2 University of Medical Sciences, Department of Child and
control children were examined. -1438A/G, 102T/C and His452Tyr
Adolescent Psychiatry, Poznan, Poland
polymorphisms of 5-HT2A were genotyped by polymerase chain * Corresponding author.
reaction-restriction fragment length polymorphism (PCR-RFLP)
method. Background and aims.– Inflammation and cytokines have emerged
Results.– There is Significant increase of the G allele and the GG as a promising target in mood disorders research, however there
genotype of the -1438A/G polymorphism was observed in children are still very limited numbers of study regarding inflammatory
alterations. The aim of this study was to investigate levels of 2: Referred to AMHS by Primary care or Emergency Units (9,3%):
interleukins: IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, associated with emergency room visits but not with pharmaco-
IFN-gamma and TNF-alpha in serum of adolescent and young adults logical treatment.
with mood disorders compared to healthy controls. 3: Dropped-out of CAMHS before transition (46,8%): associated
Methods.– We involved 79 patients aged 12–24 years with a with depressive, adaptive or anxiety disorders or to not having a
primary diagnosis of mood disorders: bipolar disorder (BP) and diagnosis and/or no pharmacological treatment.
unipolar disorder with BP spectrum, control group consisted 35 4: On-going treatment at CAMHS after transition age (9,7%):
persons. Clinical diagnoses according to DSM-IV-TR criteria were associated with psychosis, bipolar or serious neurodevelopmen-
assessed. Symptoms severity was rated using the Hamilton Depres- tal disorders and/or previous hospitalizations or pharmacological
sion Rating Scale (HDRS) and Young Mania Rating Scale (YMRS). treatment.
Serum protein concentrations were determined using Human 5: Referred by CAMHS to other services than AMHS (5%): associ-
High-Sensitivity Cytokine Multiplex Assay (Bio-Techne). Statistical ated with emergent personality disorder and/or police records
analyses were performed using Mann-Whitney U test and Spear- Conclusions.– Patients more likely to be lost are those with emo-
man’s correlation. tional disorders and without pharmacological treatment. Patients
Results.– Only Il-8 and TNF-alpha levels were detected in serum with more severe disorders are more likely to be ongoing in CAMHS.
samples. TNF-alpha levels showed negative correlation with HDRS Disclosure of interest.– The authors have not supplied a conflict of
scores (p = 0.005) and positive correlation with YMRS scores interest statement.
(p = 0.009). Compared concentrations of Il-8 and TNF-alpha to con-
trols we detected: in drug-free subgroup lower Il-8 (p < 0.01); in
medicated patients higher TNF-alpha (p = 0.05) and decreased Il-8 E-PP0181
in patients with family history of affective disorder (p = 0.05). We Whether the diet could affect course
found strong positive correlation between Il-8 and TNF-alpha levels of ASD comorbid symptoms? the
only in female patients group.
relationship between food intake and
Conclusions.– Our results shows correlations of IL-8 and TNF-
alpha levels with clinical features in acute episode of depres- insomnia and GI symptoms in ASD
sion/hypo/mania in young patients with mood disorders. Further patients group
studies on larger groups are recommended. Founding: National J. Rog1* , K. Skonieczna-Zydecka2 , D. Jamioł-Milc2 , H.
Science Center in Poland grant no 2011/03/D/NZ5/06146. Karakula-Juchnowicz3
1 Medical University of Lublin, 1st Department of Psychiatry-
interest statement. Psychotherapy and Early Intervention, Lublin, Poland; 2 Pomeranian
Medical University in Szczecin, Department of Biochemistry and
Human Nutrition, Szczecin, Poland; 3 Medical University of Lublin,
E-PP0180 Department of Clinical Neuropsychiatry, Lublin, Poland
Characterizing patient’s clinical
pathways at the age of transition Background and aims.– Autism spectrum disorder (ASD) is a
between child/adolescent and adult neurodevelopmental disorder characterized by dysfunctions of
mental health services (Crecer project) communication and social interactions, as well as repetitive
B. Reneses1* , A. Escudero2 , N. Tur2 , A. del Rey3 , J.D. Vaquerizo4 , M. behaviours. The growing body of evidence report high incidence
Graell5 , I. Mesian5 , L. Agüera6 , A. Ortíz7 , G. Seara3 of comorbidities in ASD, among them gastrointestinal symptoms
1 Clínico San Carlos Hospital, Complutense University, Department of (GI) and sleep problems which both negatively affect quality of life
Psychiatry, Biomedical Research Institute., Madrid, Spain; 2 Clínico in ASD patients. Nutritional status is considered as a possible factor
San Carlos Hospital, Institute of Research IdISSC., Department of involved in the etiology of these comorbidities.
Psychiatry, Biomedical Research Institute., Madrid, Spain; 3 Institute The aim of the study was to evaluate (1) the prevalence of insom-
of Research IdISSC, Department of Psychiatry, Madrid, Spain; 4 nia, GI symptoms and (2) food intake in ASD patients. We made an
Gregorio Marañón General University Hospital., Department of attempt to find the relationship between these variables.
Psychiatry, Madrid, Spain; 5 Niño Jesús University Hospital, Methods.– The study included 69 patients (84.06% boys), aged 3–24
Department of Psychiatry, Madrid, Spain; 6 12 de Octubre University year old who fulfilled DSM-IV criteria for ASD diagnosis. Medi-
Hospital, Complutense University Madrid, Department of Psychiatry, cal information (including GI symptoms), 3-day recall food intake
Madrid, Spain; 7 La Paz University Hospital, Department of record and Athens insomnia scale were collected.
Psychiatry, Madrid, Spain Results.– We found relationship between the severity of GI symp-
* Corresponding author. toms and (1) folate, fibre, vitamin C intake, %energy derived
from carbohydrates (negative) (2) severity of insomnia (positive)
Background and aims.– In spite of recent evidence about the gap (p < 0.05) in boys. A relationship between severity of insomnia
in health care between Child and Adolescent (CAMHS) and Adult and (1) %energy derived from carbohydrates (positive) and (2)
Mental Health Services (AMHS) at the transition age, data are still %energy derived from fat (negative) in subgroup of girls were found
very scarce. (p < 0.05).
Objectives.– To identify and characterize clinical pathways in Conclusions.– Nutritional deficiencies could be one of the potential
patients in CAMHS at the transition age. factor affecting the intensity of comorbidities in ASD patients. As (1)
Methods.– Retrospective study of a cohort of individuals that risk of inadequate nutrients intake, and (2) probable relationship
reached the age of 18 in an 18-month period and received treat- between nutritional status and insomnia and GI symptoms may be
ment at CAMHS without a discharge in 7 catchment areas in Madrid involved in ASD clinical course, dietary intervention could improve
(Spain). Subjects were studied two years before transition and 6 the quality of life this group of patients.
months after treatment at AMHS. Variables: socio-demographic, Disclosure of interest.– The authors have not supplied a conflict of
clinical and related to transition process. interest statement.
Results.– Five clinical pathways were identified
1: Referred to AMHS by CAMHS (29.2%): associated with previ-
ous hospitalizations, day hospital care, emergency room visits,
pharmacological treatment and/or eating disorders.
E-PP0182 fore, the delinquent behavior of the sub-experts can be viewed

Clinical characteristics of depression as provoked by unfavorable microsocial factors. The main share
in child and adolescents among offenses committed by adolescents was property crimes –
L. Sahli* , M. Hamza, H. Guedria, W. Askri, S. Bourgou, F. Charfi, A. 78,3%; crimes against life and health – 11,1%, as well as crimes
Belhadj against sexual inviolability – 6,4%. In the process of outpatient
Monji Slim Hospital, Child Psychiatry Department, Tunis, Tunisia forensic psychiatric examination, psychiatric disorders were iden-
* Corresponding author. tified in 88,7% of cases in which the structure was dominated by
organic personality disorder, specific personality disorder, behav-
Background and aims.– Depression in youths is often underdiag- ioral disorder and mental retardation.
nosed because of its heterogeneous clinical presentation which Conclusions.– In Russia there are regions with high crime of ado-
varies according to age and makes the diagnosis complex. lescents because of a difficult social and economic situation and a
The aim of this study was to compare the clinical characteristics of large number of dysfunctional families.
depression according to age groups. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– A retrospective study on 95 youths followed up for interest statement.
depressive disorders from January until August 2018. The sam-
ple was divided into children and adolescent groups choosing as
limit the age of 12. Chi-square test was used to compare clinical E-PP0184
characteristics and t-test for unpaired samples when comparing Audit on the application and
means. implementation of the tool for
Results.– The sample consisted of 56 adolescents (mean age: 14,45) assessment of suicide risk: adolescent
and 40 children (mean age: 8,7) with female predominance in ado-
lescent and male in children group. Children were mainly referred
version
E. Saliba* , N. Camilleri
for behavioral disturbances (34,2%) while adolescents for suicidal
Mount Carmel Hospital, Psychiatry, H’Attard, Malta
behavior (43%). The onset of the disorders dated from longer in * Corresponding author.
the children group. Irritability was found more significantly among
adolescent as well as withdrawal, anhedonia, insomnia, suicidal Background and aims.– Patient safety is of paramount importance.
ideation and suicide attempts (for all p < 0,01). Conduct disorders The Tool for Assessment of Suicide Risk: Adolescent Version (TASR-
were also more prevalent but concerned only runaways (p = 0,039). A) is a semi-structured instrument which is a clinically useful tool
In the children group, attentional problems were more reported to identify imminent suicide risk in depressed adolescents. It can be
(p = 0,011) and enuresis was more prevalent (p = 0,003) but not utilised to assess risk at baseline and throughout the management
encopresis and neither somatic complaints. Evolution of the disor- period.
ders were similar between groups but follow-up was more irregular Furthermore, the TASR-A comprises the Kutcher Adolescent
among children (p = 0,022) with more lost sight. Depression Scale (KADS-6) which is a 6-item self-rating scale to
Conclusions.– Clinical features in depression disorders happen to aid with diagnosis and severity of depression of the adolescent. It
differ according to the period of life and the recognition of this has good reliability and validity, comparable to Beck’s Depression
specificity is necessary to insure an optimal care and prevent com- Inventory, with sensitivity and specificity of 92% and 71% respec-
plications. tively.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– This was a prospective audit where the TASR-A was
interest statement. implemented in clinical practice at the Young People’s Unit (YPU),
in Malta. Adolescents aged twelve to eighteen years were included.
Suicide risk was assessed using the TASR-A on admission and during
hospitalization.
E-Poster Presentation: Child and Adolescent
Results.– The most common reason for admission in the Young
Psychiatry - Part V People’s Unit was depression with self harm or suicidal ideation
(45%).
36% had suicidal ideation and 40% had a past history of suicidal
E-PP0183 behavior.
The socio-psychological and clinical According to the KADS-6, 60% of adolescents had symptoms of
characteristics of adolescents in depression upon admission.
According to the TASR: A, 30% of admissions were high risk to self
Russia who have committed crime & 50% of moderate risk.
acts Conclusions.– The TASR provides an objective assessment of suicide
A. Sakharov* , M. Klinova risk which substantiates clinical judgement. With its implementa-
1 Chita State Medical Academy, Faculty of Psychiatry- Narcology and
tion, patients who are of high risk to self will be identified and
Medical Psychology, Chita, Russia managed using the biopsychosocial patient model. This objective
tool will support doctors further in a medicolegal inquest.
Background and aims.– To study socio-psychological and clinical
interest statement.
characteristics of adolescents who have committed socially dan-
gerous acts.
Methods.– We analyzed with continuous method on the basis of the E-PP0185
Regional Clinical Psychiatric Hospital named after V. Kh. Kandin-
sky 869 conclusions of out-patient forensic psychiatric expertise in
Transition program (tp) at infanta
criminal cases of adolescents. leonor hospital
Results.– It is established that the majority of adolescents with crim- C. Sanahuja Muñoz* , C. Sanchez Novella, M. Diez del Corral Belda,
inal behavior have psychopathologic ally burdened heredity for L. De Anta, A. Rodriguez Quintero, F.J. Quintero Gutierrez del
alcoholism of parents, are brought up more often in incomplete, Alamo
dysfunctional families with a low material level, in most cases in Hospital Infanta Leonor, Mental Health Service, Madrid, Spain
conditions of inadequate care with elements of aggression. There-
Background and aims.– A Transition Program is defined as a planned children and adolescents. This was achieved through the develop-
transfer of adolescents and young adults from child and adolescent ment of the STOP Suite of Suicidality Measures.
centers and resources to those for adults, in a process that takes into Objectives.– To develop a single assessment scale for the predictors
account the medical, psychological and educational needs of young of suicidality in children and adolescents.
people during this period. Our aim is to define how this program is Methods.– The STOP Suite of Suicidality Measures was embedded
being implemented in our Hospital. onto the HealthTrackerTM platform and was validated in seven
Methods.– A description of the Transition Program that is being cohorts from six European Union countries (UK, Italy, Spain, France,
carried out in the mental health department of the Infanta Leonor Netherlands and Germany) involving 1002 children and adoles-
Hospital. cents aged from 8–18 years.
Results.– The Transition Program team consists of a psychiatrist, a Results.– The scales from the STOP Suite of Suicidality measures
clinical psychologist, a specialized nurse and a social worker. The allowed the identification of specific domains for suicidality that
follow-up, described here, is done on an outpatient basis for ado- were developed into a single HealthTrackerTM based scale. The
lescents and young adults (14 to 26 years old) with severe mental psychometric properties of the HealthTrackerTM based suicidality
illness, from the moment of diagnosis to the point of successful prediction scale will be presented.
transition to adult mental health services. Conclusions.– The findings from the STOP suite of suicidality mea-
Conclusions.– As it is described in literature, as well as observed sures succeeded in developing a model that predicts the risk of
in clinical practice, there is a strong need for specialized services suicidality in young people.
during the transition period. On behalf of the STOP consortium.
Disclosure of interest.– The authors have not supplied a conflict of Disclosure of interest.– The authors have not supplied a conflict of
interest statement. interest statement.
E-PP0186 E-PP0187
A single assessment scale for the Parents of children with recent
predictors of suicidality in children psychiatric diagnosis: a look at the
and young adolescents possible impact of family income,
P. Santosh1,2,3* , K. Lievesley1,2,3 , J. Singh1,4 , C. Arango5 , J. parental education, psychopathology
Buitelaar6 , J. Castro-Fornieles7,8,9 , D. Coghill10,11,12 , R. Dittmann13 , and employment
P. Hoekstra14 , C. Llorente5 , D. Purper-Ouakil15 , U. Schulze16 , A.
A. Şeker1* , S. Ozmen2 , E. Demirci2
Zuddas17 , N. Iakovidou1 , F. Fiori1,2,3 1
1 King’s College London, Child and Adolescent Psychiatry, London,
Erciyes University Hospital, Child and Adolescent Psychiatry,
Kayseri, Turkey; 2 Erciyes University, Child/Adolescent Psychiatry,
United Kingdom; 2 South London and Maudsley NHS Foundation Kayseri, Turkey
Trust, Centre for Interventional Paediatric Psychopharmacology and * Corresponding author.
Rare Diseases, London, United Kingdom; 3 HealthTracker,
HealthTracker, Gillingham, United Kingdom; 4 South London and Background and aims.–
Maudsley NHS Foundation Trust, Child and Adolescent Psychiatry, Introduction.– The relationship that socioeconomic status and
London, United Kingdom; 5 Hospital General Universitario Gregorio parental mental health have with children’s mental wellbeing has
Marañón, Child and Adolescent Psychiatry, Madrid, Spain; 6 Radboud been supported by many researchers. Identifying such correlation
University Medical Centre, Cognitive Neuroscience- Donders Institute can contribute to preventative measures.
for Brain- Cognition and Behaviour, Nijmegen, The Netherlands; 7 Objectives.– In this study, it is aimed to explore the patterns of
Hospital Clinic of Barcelona, Child and Adolescent Psychiatry and parental education, employment, psychiatric diagnosis and income
Psychology, Barcelona, Spain; 8 CIBERSAM, Centro de Investigación in first-admission child/adolescent psychiatry patients.
Biomédica en Red de Salud Mental, Madrid, Spain; 9 University of Methods.– Methods: 152 children with first-time psychiatric diag-
Barcelona, Psychiatry and Clinical Psychology, Barcelona, Spain; 10 nosis have been randomized from the clinical cohort. The data on
University of Melbourne, Paediatrics and Psychiatry, Melbourne, household income, education levels, mental, marital and employ-
Australia; 11 University of Dundee, Division of Neuroscience, Dundee, ment status of their parents were collected through questionnaires
United Kingdom; 12 Murdoch Children’s Research Institute, Murdoch and individual interviews. The data were compared with the
Children’s Research Institute, Melbourne, Australia; 13 University of National Database (ND) rates via suitable statistical tests.
Heidelberg, Child and Adolescent Psychiatry, Mannheim, Germany; 14 Results.– Results: Maternal unemployment, maternal/paternal edu-
University of Groningen, Child and Adolescent Psychiatry, Groningen, cation less than 8 years and family income at ‘minimum wage’ (less
The Netherlands; 15 CHRU Montpellier, Médecine Psychologique de than 250 Euros) were found significantly higher than ND averages.
l’Enfant et de l’Adolescent, Montpellier, France; 16 University of Ulm, Maternal unemployment had the most significant difference with
Child and Adolescent Psychiatry/Psychotherapy, Ulm, Germany; 17 a p-value of 0.020858 (p < .05). Surprisingly, divorced/separated
University of Cagliari, Child and Adolescent Neuropsychiatry Unit, status and parental psychopathology were not significantly over-
Cagliari, Italy represented.
Conclusions.– Conclusions: With this study, maternal unemploy-
ment merits a special regard, contradicting the conventional take
Background and aims.– on motherhood. The need for further exploration on such sociode-
Introduction.– Although, the rates of suicide in childhood and early mographic patterns is once again recognized.
adolescence suicide are rare, in adolescents and young adulthood, Disclosure of interest.– The authors have not supplied a conflict of
however, suicide rates have become increasingly more prevalent. interest statement.
There is a paucity in the evidence base in terms of studies that
have explored suicidality in young people in which all relevant
bio-psycho-social mediators and risk have been simultaneously
collected to study their relevance. Part of the EU, FP7 ‘Suici-
dality: Treatment Occurring in Paediatrics’ STOP project was to
develop a comprehensive HealthTrackerTM based methodology for
the assessment and monitoring of suicidality and its mediators in
E-PP0188 symptoms was determined by scores on the Korean ADHD Rating

Effective interpersonal contact with Scale (K-ARS) in children and healthy controls.
juvenile convicts as a factor of their Results.– The difference of median plasma EPO levels between 2
groups was not statistically significant. Participants in the highest
mental health and psychological tertiles of plasma EPO had a 1.49 times higher risk of ADHD than
well-being those in the lowest tertile, and those in the second highest ter-
F. Ushkov1 , L. Shaigerova1 , Y. Zinchenko1 , O. Ezhova2 , A. Dolgikh1 , tile had a 2.39 times higher risk of ADHD than those in the lowest
R. Shilko1* tertile. Plasma EPO levels significantly correlated positively with
1 Lomonosov Moscow State University, Psychology, Moscow, Russia;
K-ARS scores including hyperactivity – impulsivity and total scores
2 Samara Law Institute of the Federal Penitentiary Service of Russia,
in 2 groups. A linear regression analysis showed that inattention
Management and Information and Technical Support of the score was significantly higher (3.04, [CI: 0.64, 5.44]) in the second
Penitentiary System, Samara, Russia highest tertile of plasma EPO comparing those in the lowest tertile.
Hyperactivity-impulsivity score was significantly higher (2.19, [CI:
0.10, 4.38]) in the highest tertile of plasma EPO comparing those in
Background and aims.– Interpersonal contact with the convict is
the lowest tertile. And, total K-ARS scores was significantly higher
a demanding task for both the correctional officer and the crim-
(5.06, [CI: 0.74, 9.38]) in the second highest tertile of plasma EPO
inal, especially in the case of interaction with a juvenile offender.
comparing those in the lowest tertile.
The communication could be accompanied by behavioral problems,
Conclusions.– These findings suggest plasma EPO levels in untreated
emotional instability and low confidence of a young convict. We
ADHD children did not differ with healthy controls.
studied the structure and the development of interpersonal contact
between psychologists working in correctional camps and juvenile
interest statement.
convicts.
Methods.– Psychologists working in correctional camps (n = 51)
aged 22 to 54 (M = 36.7) participated in the study (33 were female). E-PP0190
The method of unfinished sentences and the standardized self-
report technique were used to study the components and phases
Psychometric evaluation of the
of interpersonal contact. swedish adolescent and parent
Results.– Content analysis of unfinished sentences and the self- versions of the child sheehan
reports identified several components of interpersonal contact disability scale in psychiatric patients
between psychologists and juvenile convicts: perception and C. Soler Torres1* , K. Sonnby1 , S. Vadlin1 , S. Olofsdotter1 , M.
knowledge about situation; willingness to interact; strategy and Ramklint2 , K. Nilsson1
tactics of behavior; reflection; availability of internal means for the 1 Center for Clinical Research, Department of Neuroscience- Uppsala
mental state regulation during interaction with the correctional University, Västerås, Sweden; 2 Uppsala Universitet, Medicin,
officer. The development of interpersonal contact goes through sev- Uppsala, Sweden
eral stages: communication planning; creating a partner’s portrait; * Corresponding author.
creation of environment facilitating the establishment of contact;
establishment of interpersonal relations; evaluation of the con- Background and aims.–
vict’s attitude to the beginning of communication; maintenance of Introduction.– There is no published validation of the Swedish trans-
interpersonal communication; stimulating motivation for further lations of the Child Sheehan Disability Scale (CSDS) for use in
communication. adolescents or for the parent version (CSDS-P). The scale is used
Conclusions.– The success of interpersonal contact between prison for report of functioning in psychiatric settings.
staff and convict, as well as mental state, psychological well-being Objectives.– To explore the psychometric properties of the CSDS and
and the result of re-education of young criminals depend on careful the CSDS-P in adolescent psychiatric patients.
creation of all components of contact and paying attention to the Methods.– Consecutively referred patients from two child psychi-
stages of contact development of contact is undergoing. atric clinics in Vestmanland (n = 107) were assessed with CSDS
Disclosure of interest.– The authors have not supplied a conflict of and CSDS-P, Strengths and Difficulties Questionnaire (SDQ), inter-
interest statement. viewed with Schedule for Affective Disorders and Schizophrenia for
School-Age Children-Present and Lifetime version (K-SADS-PL).
Results.– Internal consistency (Cronbach’s alpha) was .813 and .842
E-PP0189 for CSDS and CSDS-P respectively. For both scales, principal com-
There is a correlation between plasma ponent analyzes (PCA) showed one component. The correlations
between the total scores of CSDS and CSDS-P in relation to a general
erythropoietin levels and attention
K-SADS-PL symptom summation index was .416, p < .001 and .302,
deficit hyperactivity disorder p = .001, respectively. The correlation of the total scores of CSDS-P
symptoms and SDQ parent was .328, p < .001.
S. Shim1* , H. Jung2 , S.W. Hahn3 , J. Yang4 , J.S. Kim1 , Y.S. Lee1 , I.H. Conclusions.– The Swedish versions of CSDS and CSDS-P have sim-
Lee2 , M.G. Hwang3 ilar psychometric properties as the English version of the CSDS.
1 Soon Chun Hyang university hospital, Psychiatry, Cheonan,
Republic of Korea; 2 Soon Chun Hyang University Hospital, interest statement.
Psychiatry, Bucheon, Republic of Korea; 3 Soon Chun Hyang
University Hospital, Psychiatry, Seoul, Republic of Korea; 4 Chonbuk
National University Hospital, Psychiatry, Chonju, Republic of Korea E-PP0191
The association of parental regulation
Background and aims.– The aim of the present study was to exam- of internet game use and risk of
ine the Erythropoietin (EPO) plasma levels and determine whether internet gaming disorder in
there was any correlation between plasma EPO levels and clinical adolescents
characteristics of attention deficit hyperactivity disorder (ADHD). H.J. Son
Methods.– Plasma EPO levels were measured in 78 drug-naïve chil- College of Medicine The Catholic University of Korea, Preventive
dren with ADHD and 81 healthy children. The severity of ADHD Medicine, Seoul, Republic of Korea
Background and aims.– It is more difficult for adolescent to con- Conclusions.– Creating cognitive profiles of normal IQ HFA chil-
trol Internet gaming behavior than adults. Previous studies have dren with varying intensification of autistic symptoms seems to be
showed different results on the relationship between parental beneficial in planning clinical interventions. Monitoring cognitive
regulation of Internet game use and the risk of Internet gaming abilities depending on psychopharmacotherapy may be helpful in
disorder (IGD) in adolescents. The purpose of this study was to controlling side effects or in the decision to initiate psychopharma-
examine the association of parental regulation of Internet game use cotherapy.
and risk of IGD in adolescents through prospective observation. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– The Internet User Cohort for Unbiased Recognition of interest statement.
Gaming Disorder in Early Adolescence (iCURE) study is an ongoing
prospective cohort study in Korea. Of 2,319 participants enrolled at
the baseline, 2,206 were tracked in the one-year follow-up survey. E-PP0193
The authors analyzed the data of 1,726 secondary school students Effects of childhood abuse and neglect
who lived with parent. Risk of IGD was measured by the Internet on suicidal behavior in an adolescent
Game Use-Elicited Symptom Screen (IGUESS). The one-year follow-
clinical population
up data was used as the outcome variable. Parental regulation, the
I. Kunovski* , G. Nikolova, A. Filipovska, L. Trpcevska, M. Raleva
exposure variable, meant that the parents checked the time spent
University Clinic of Psychiatry, Child and Adolescent Psychiatry,
on Internet gaming of their child and stopped them when they use
Skopje, FYR Macedonia
Internet games. To determine the independent effect of the parental * Corresponding author.
regulation of Internet game use on the risk of IGD, multiple logistic
regression analysis was conducted. Background and aims.– Suicide is among the leading causes of death
Results.– The result showed that parental regulation of Internet in the adolescent population. Little attention has been dedicated to
game use was not significantly related to the adolescents’ risk of the relationship between subtypes of childhood abuse and neglect
IGD (OR = 1.20, 95% CI: 0.75–1.93). and suicidal behavior in youth. The literature is especially limited
Conclusions.– It is not appropriate to emphasize parents’ responsi- in regard to the adolescent clinical population. The current study
bility of adolescents’ IGD. aims to explore the effects of childhood abuse and neglect (phys-
Disclosure of interest.– The authors have not supplied a conflict of ical abuse, emotional abuse, sexual abuse, emotional neglect and
interest statement. physical neglect) on suicidal behavior (ideation and attempt) in a
clinical sample of adolescents.
Methods.– Data was collected from adolescents (ages 11–18) under
treatment at the University Clinic of Psychiatry in Skopje, Macedo-
E-Poster Presentation: Child and Adolescent nia. Childhood abuse and neglect was assessed using the Childhood
Psychiatry - Part VI Trauma Questionnaire and suicide risk using the Mini-International
Neuropsychiatric Interview for Children and Adolescents.
Results.– A total of 68 (33 male, 35 female) adolescents partici-
E-PP0192 pated in the study (40 in-patients, 28 out-patients). The prevalence
Cognitive functioning in children with of suicidal ideation was 69% and suicide attempts 47%, while for
childhood trauma it was 53% (emotional abuse), 43% (physical
autism spectrum disorder with
abuse), 25% (sexual abuse), 51% (emotional neglect) and 29% (phys-
normal intelligence ical neglect). Emotional abuse (p = 0.02) and emotional neglect
M. Konop (p = 0.03) significantly predicted the presence of suicidal ideation.
Jagiellonian University Medical College, Department of Conclusions.– In line with available research, emotional abuse and
Psychotherapy, Kraków, Poland neglect showed to be the most prevalent childhood adverse expe-
Background and aims.– As the majority of children with an autism riences and the strongest predictors of suicidal ideation in the
spectrum disorder (ASD) have more or less severe cognitive impair- adolescent clinical population. The results may point to the pre-
ments, neuropsychological assessment has important implications vention of childhood abuse and neglect as an important measure
in education and psychotherapeutic process. Intelligence tests are in reducing suicidal behavior in youth under treatment.
often used in cognitive assessment and in the division of individ- Disclosure of interest.– The authors have not supplied a conflict of
uals into high or low functioning groups. This procedure seems interest statement.
to be insufficient in examination of autistic children with normal
intelligence.
The objective of the research was to determine possible differences E-PP0194
in cognitive functioning between children with high function-
An influence of certain biological
ing autism (HFA) and normally developing children. Received
psychopharmacotherapy and intensification of autistic symptoms factors in determination of autism
were controlled. spectrum disorders
Methods.– 21 children with ASD with normal intelligence were M. Lapshin
examined. The study was performed using selected tests of the Scientific and Practical Center of Mental Health n.a. G.E. Sukhareva,
Battery of Cognitive Functions PU-1. The results were compared 12th Psychiatric Department, Moscow, Russia
with the tool standard. The results of children using and not using Background and aims.– A number of autism spectrum disorders
psychopharmacotherapy were compared. The correlation between investigations have shown that deficiency of the protein H2AX
intensification of autistic symptoms and cognitive functioning was causes genomic instability, contributing to cell death. Can be
analyzed. expected that cells with high NRF2 production will maintain a high
Results.– HFA group received results lower than the tool standard level of H2AX.
in: selection and concentration of attention, phonological loop, Aim is to establish possible interrelations of some genetic factors
working visual memory, number of errors made, categorial fluency. and features of structural and dynamic characteristics of autism
Received psychopharmacotherapy did not differentiate the exam- spectrum disorders.
ined children in terms of the cognitive functions studied. Intensified Methods.– The study was conducted in the framework of research
autistic symptoms relate with lower working memory and shorter «Polymorphism of locus NRF2 and the relationship of individual
time of planning task. clinical parameters with allelic variants of NRF2». 94 children aged 3
to 7 years with autism spectrum disorders were examined (clinical- E-PP0196

psychopathological survey principle, the Childhood Autism Rating An exploration of the experiences of
Scale (CARS), Social Communication Questionnare (SCQ)/ Charac-
families with a child with autism
teristics of the sample: children’s autism (F84.02) - 61 children;
R. Loa
atypical autism with mental retardation (F84.11) - 7 children, atyp-
University of Santo Tomas, College of Nursing, Manila, Philippines
ical autism without mental retardation (F84.12) - 8, other common
Background and aims.– Families experiences many challenges in
developmental disorders with syndromic diagnosis of early child-
caring for their children with Autism. The experiences of families
hood autism (F84.8) - 18.
impacts their quality of life and their children. Understanding their
Results.– All the children participating in the investigation had a
experiences is important to help them cope with the challenges,
difference from the control group of the protein level H2AX in
and policy makers in creating programs to address their needs.
leukocytes (P = 0.039). Since the histone key repair protein H2AX
This study aims to explore and describe the experiences of couples
is a key marker of chronic genotoxic stress, characteristic of cells of
with a child with Autism. This study focused on two main questions:
patients with autism, it can be assumed that children with ASD are
1. What are the experiences of the family with a child with autism?
more prone to chronic stress.
2. How do families cope with the difficulties in caring for a child
Conclusions.– The study suggests that the genotyping of polymor-
with autism?
phic variants of NRF2 and the expression of the active forms of key
Methods.– This qualitative study utilized a phenomenological
proteins of an adaptive response to genotoxic stress will help cre-
approach to explore and describe the experiences of 20 cou-
ate personalized approaches to the treatment of autism spectrum
ples with a child with autism in the Philippines using in-depth
disorders.
interviews. Transcripts were analyzed using content analysis and
respondent validation was done to establish trustworthiness of the
interest statement.
findings.
Results.– The themes that emerged from the analysis are living a dif-
ferent way of life, difficulty in finding resources for the child, feeling
E-PP0195
of isolation from other families, and strained family relationships.
Does autism predict a worse prognosis Families cope up with the different issues by seeking emotional and
of problematic gaming? financial support from health care professionals, social workers,
C.T. Lee* , S.Y. Lee, Y.S. Kweon, H.K. Lee, K.U. Lee and other families with the same situation.
Uijeongbu St. Mary’s Hosptal The Catholic University of Korea, Conclusions.– Autism creates a social stigma among families. Sup-
Department of Psychiatry, Uijeongbu, Republic of Korea port from health care professionals, social workers, and other
families is important to help families cope with these difficul-
ties. Therefore, programs should focus on providing emotional and
Background and aims.– On contrary to risk factors, prognostic fac-
financial support to families of children with autism, and educating
tors of gaming disorder have not been studied well. Authors tried
the community about autism.
to determine psychological constructs affecting improvement of
problematic gaming.
interest statement.
Methods.– Children and adolescents aged between 10 to 16 years
participated our multicenter cohort study after written informed
consents. The 157 participants and their parents underwent var- E-PP0197
ious psychological surveys including Autism Spectrum Screening
Religious orientation mediating
Questionnaire (ASSQ), internet and smartphone addiction. They
were also interviewed for internet gaming disorder symptoms of between family prejudices and mental
the DSM-5 plus the symptom of craving. We included those who health: examining
demonstrated 3 or more positive on gaming symptoms. The base- achievement-related stereotypes for
line characteristics of the remitters and pathologic gamers (0 versus opposite gender and sect
5 or more gaming symptoms) were compared at the 6 month using A.A. Khan1 , J.A. Malik1* , S. Musharraf2 , C.A. Lewis3,4
t-test or Fisher exact test with p-value of 0.05 at both side. 1 Quaid-i-Azam University, National Institute of Psychology,
Results.– The remitters and pathologic gamers demonstrated sig- Islamabad, Pakistan; 2 Women University, Department of Psychology,
nificant differences in regard to number of gaming symptoms Multan, Pakistan; 3 Bishop Grosseteste University, School of Social
(p < 0.001), internet addiction (p = 0.001), and smartphone addic- Sciences, Lincoln, United Kingdom; 4 University of Warwick, Centre
tion (p = 0.01) at the 6 month follow up. The two groups did not for Education Studies, Coventry, United Kingdom
show significant differences in demographics, number of gaming * Corresponding author.
symptoms, internet and smartphone addiction scores. However,
the participants who continued to their problematic gaming at 6 Background and aims.– The study proposed and tested a cognitive
month displayed higher ASSQ scores by their parents (p = 0.024). developmental model to examine the role of family prejudices in
Conclusions.– Those who continued problematic gaming behavior development and formation of religious orientation of children and
at 6 month were more likely to display higher ASSQ at the baseline. its influence on their mental health.
Higher scores on parent reported autism measurements does not Methods.– A total of 280 children and their parents 175 fathers and
necessarily indicate autism. However, there is a chance that gaming 113 mothers recruited at various schools participated in the study.
may appeal more to people who experience greater difficulties in After taking informed consent from parents, responses were col-
social interactions. lected from children in their classes whereas parents’ forms were
Disclosure of interest.– The authors have not supplied a conflict of sent to their homes. Data were collected on achievement-related
interest statement. positive and negative stereotypes against opposite gender and sect,
religious orientation, anxiety, and depression.
Results.– Based on the conceptualization of the study, parallel
models addressing gender and sectarian ingroup-outgroup classi-
fication were developed and estimated. The results supported the
conceptual model of the study addressing underlying mechanism
for the role of family prejudices in formation of religious orienta-
tion among adolescents and their effect on depression and anxiety Background and aims.– High Functioning Autism (HFA) is charac-
in children. terized by the social deficits inherent to the diagnosis of autism but
Conclusions.– The study contributed to the existing literature by whose higher IQ allows these individuals to have a better capacity
clarifying ambiguities between religious orientation and mental for learning and integration in society norms, often going unnoticed
health. Additionally, it is the first study involving a multi-informant and undiagnosed to older ages - adolescence or early adulthood.
design to test associations between these constructs in a religious However, the self-perceived difficulties of these individuals tend
community in South Asia. to cause great anguish and anxiety, causing other symptoms that
Disclosure of interest.– The authors have not supplied a conflict of can be confused with psychotic states.
interest statement. Our aim is to raise awareness and illustrate how the difficulty in
diagnosing this individuals can condition great suffering with the
consequent development of confusing and unclear psychopathol-
E-PP0198 ogy.
Childhood trauma history and Methods.– Case report and revision of the most recent literature on
psychotic-like experiences in 50 the topic with the key-words: “high functioning autism”, “misdi-
adolescent patients hospitalized for agnosis”, “adolescence”.
Results.– Male, 15 years old, without previous follow-up in Psy-
the first time: a trans-diagnostic and
chiatry. Between November and December of 2017 went to the
prospective approach emergency department several timeswith high anxiety, irritabil-
J. Mallet1* , S. Guessoum2 , F. Brunet2 , A. Couturier2 , S. Tebeka2 , E. ity, insomnia and self-referential delirant ideas, culminating in an
Kiesmann2 , N. Mazer3 , Y. Le Strat2 , C. Dubertret2 episode of aggression in school and his suspension. He was hospi-
1 Psychiatry Department- CHU Louis Mourier- APHP- Colombes -
talized in an inpatient unit with the suspicion of a first psychotic
Université Paris Diderot - Inserm U894- Institut de Psychiatrie et outbreak. After a carefull evaluation he was diagnosed with HFA
Neurosciences de Paris IPNP, Psychiatry, Paris, France; 2 Psychiatry and prolonged depressive symptoms, without somatic symptoms
Department- CHU Louis Mourier- APHP- Colombes - Université Paris (ICD-9).
Diderot, Psychiatry, Colombes, France; 3 Psychiatry Department- Conclusions.– This adolescent did not have any previous monitoring
CHU Louis Mourier- APHP- Colombes - Université Paris Diderot - or diagnosis that justified his difficulties. The parents were con-
Inserm U894- Institut des Psychiatrie et Neurosciences de Paris IPNP, fused, not understanding what was happening. The school and the
Psychiatry, Colombes, France Hospital were also unprepared. This case illustrates the importance
of early detection and follow up as well as the education of their
Background and aims.– Psychotic like experiences (PLEs) and care-takers.
trauma history are both common and underevaluated in clinical Disclosure of interest.– The authors have not supplied a conflict of
practice. Valid autoquestionnaires could be more acceptable for interest statement.
adolescent population to improve their systematic assessment.
Aims.– To evaluate (i) the prevalence of different psychotic expe-
E-PP0200
riences in first-time psychiatric patients, without any diagnostic
prejudge, and (ii) their association with childhood trauma. Primary and secondary prevention of
Methods.– Adolescents (16–26 yo) hospitalized for the first time the anxiety disorders in children
and without antecedents were included. We recorded diagnosis T. Matkovska1* , N. Bagatska2 , E. Mykhailova3 , D. Mitelov3 , A.
at the end of hospitalization, updated 6 months after. Psychotic Goloborodko4
1 1SI «Institute for Children and Adolescents Health Care of the NAMS
experiences were measured using PQ16 (Prodrome Questionnaire).
Trauma history (emotional, physical and sexual) was assessed with of Ukraine»- Ukraine- 2. V. N. Karazin Kharkiv National University-
the CTQ (Childhood Trauma Questionnaire). Toxic comorbidities Ukraine, psychiatry, Kharkov, Ukraine; 2 1SI «Institute for Children
were registered. and Adolescents Health Care of the NAMS of Ukraine»- Ukraine- 2. V.
Results.– 50 patients were included in the study. The prospec- N. Karazin Kharkiv National University- Ukraine, genetic, Kharkov,
tive follow-up of patients showed at 6months: schizophrenia 28%, Ukraine; 3 SI «Institute for Children and Adolescents Health Care of
mood disorders 44%, anxiety disorders 6%, personality disorders the NAMS of Ukraine», psychiatry, Kharkov, Ukraine; 4 V. N. Karazin
24%, brief psychotic episode: 2%, others 14%. The evaluation of psy- Kharkiv National University- Ukraine, student 4 year, Kharkov,
chotic experiences showed high scores regardless of first diagnosis Ukraine
and 6months diagnosis. All items were widely represented. There
was a significant correlation between sexual abuse during child-
hood and PLES experiencing (spearman rho = 0.45, p = 0.007) and a Background and aims.– The existing methods for the treatment of
significant association between the two groups. P = 0.04). Only two the anxiety disorders (AD) are aimed at correction of anxiety and
experiences were associated with final schizophrenia diagnosis: depression, but they are not intended for taking measures to pre-
taste/olfactory hallucinations and reference ideas. vent the development and prophylaxis of recurrences.
Conclusions.– PLEs are highly common in adolescents first hospi- Methods.– The study included 120 children with AD. Clinical
talized, and are associated with sexual abuse history, regardless of psychopathological, somatoneurological, psychological (Children’s
diagnosis. Our results support the importance of a dimensional and Depression Rating Scale Revised - CDRS-R); the Spielberg scale
trans-nosographic approach to psychotic phenomena especially to estimate personality and reactive anxiety,and genetic meth-
when studying environmental risk factors. ods (determination of the karyotype – the frequency and type of
Disclosure of interest.– The authors have not supplied a conflict of chromosomal aberrations in the peripheral blood lymphocytes -
interest statement. standard methodology, as well as family accumulation of the mul-
tifactorial diseases in the genealogy of children).
Results.– Children with AD have a high share and different types of
E-PP0199 chromosomal disorders (chromatid, chromosomal, and genomic)
Hidden high functioning autism – a and also different contribution of heredity into their formation. In
case report the basis of treatment and prevention is the task of improving the
M. Marques* , T. Cartaxo, V. Santos method of the AD primary and secondary prophylaxis, taking into
CHUC, Child and Adolescent Psychiatry, Coimbra, Portugal consideration the genetic component: the use of Cytoflavin in com-
* Corresponding author. bination with folic acid on the background of cognitive-behavioural
psychotherapy. Clinical and dynamic observations have established 1 Loewenstwein Rehabilitation Hospital, Child Development Center,
certain regression of the anxiety and depression symptoms, elim- Raanana, Israel; 2 Loewenstein Rehabilitation Hospital, Child
ination of cognitive disturbances, improvement of psychosocial Development Center, Raanana, Israel; 3 Tel Aviv Medical Center, Sleep
adaptability of the child with AD, stabilization of the patient’s Disorders Center, Tel Aviv, Israel; 4 Haifa university, Department of
genome, and prevention of recurrences in the near and distant Occupational Therapy, Haifa, Israel
future. * Corresponding author.
Conclusions.– The proposed treatment complex with the lowest

pharmacokinetic load will improve the psychosocial adaptability Background and aims.– Sleep disorders have been reported in up
and stabilization of the patient’s genome. to 85% of children with ADHD. 40%-60% of children with ADHD
Disclosure of interest.– The authors have not supplied a conflict of exhibit sensory modulation difficulties (SMD) in addition to the
interest statement. core symptoms of ADHD. Children with ADHD who exhibit sensory
symptoms have been reported to experience more significant func-
tional difficulties. We aimed to evaluate whether SMD affect sleep
E-PP0201 characteristics of children with ADHD.
Diagnostic methodology of anxiety Methods.– 41 children with ADHD and 39 controls (ages 8–11)
were recruited and assessed, using the Conner’s Parent Rating
disorders in children
Scale–Revised: Short Form, the Short Sensory Profile (SSP) and The
T. Matkovska1* , E. Mykhailova2 , D. Mitelov2 , N. Mikhanovska3 , A.
Children’s Sleep Habits Questionnaire (CSHQ).
Goloborodko4
1 1SI «Institute for Children and Adolescents Health Care of the NAMS Results.– In the ADHD group, 78.1% of children lower quality
of sleep, compared to 21.9% of children in the control group
of Ukraine»- Ukraine- 2. V. N. Karazin Kharkiv National University-
(2 = 16.84, p < 0.001). A multivariable model revealed that chil-
Ukraine, Psychiatry, Kharkov, Ukraine; 2 SI «Institute for Children and
dren with ADHD and SMD had sleep scores that were lower than
Adolescents Health Care of the NAMS of Ukraine»- Ukraine,
controls, whereas children with ADHD and no SMD were indis-
Psychiatry, Kharkov, Ukraine; 3 1. V. N. Karazin Kharkiv National
tinguishable from controls. Use of stimulants, gender, mother’s
University- Ukraine- 2-SI «Institute for Children and Adolescents
education and age had no significant contribution.
Health Care of the NAMS of Ukraine»- Ukraine, Psychiatry, Kharkov,
Conclusions.– In this pilot study, we found that difficulties in mod-
Ukraine; 4 V. N. Karazin Kharkiv National University- Ukraine,
ulation of sensory input may correlate with lower quality of sleep
Student 4year, Kharkov, Ukraine
* Corresponding author. in children diagnosed with ADHD.
Background and aims.– The ICD-10 (International Classification of interest statement.
Diseases-10) and DSM-IV (Manual on Diagnosis and Statistics of
Mental Disorders) contain lots of specific anxiety and depressive
disorders. The use of diagnostic criteria for the anxiety disorders E-PP0203
(AD) according to ICD-10 or DSM-IV-R gives a discrepancy in almost Oxysterols profile in children with
50% of cases. autism spectrum disorders
Methods.– The study included 160 children, aged 6–18 years, G. Sahar1 , M. Messedi1 , M. Naifar2 , I. Hadj Kacem3 , M. Chtourou2 ,
with anxiety disorders. Clinical psychopathological, somatoneu- D. Ben Touhemi3 , H. Ayedi3 , L. Iuliano4 , Y. Moalla3* , F. Ayadi2
rological, neurophysiological, psychological (Children’s Depression 1 Unit of research “Molecular Bases of Human Diseases, Faculty of
Rating Scale Revised - CDRS-R); the Spielberg scale to estimate per- Medicine of Sfax, Sfax, Tunisia; 2 University of Sfax & Habib
sonality and reactive anxiety, as well as “Me and my illness” and Bourguiba Hospital, Laboratory of Biochemistry, Sfax, Tunisia; 3
“Man in the Rain” projective drawing tests), and Luria’s Memorizing University of Sfax &Hedi Chaker Hospital., Department of Child and
10 words technique. Adolescent Psychiatry, Sfax, Tunisia; 4 Vascular Biology and Mass
Results.– The psychopathological symptoms of AD in children are Spectrometry Laboratory, Department of Medical Sciences and
heterogeneous and have age-related characteristics: AD in children Biotechnology- University of Roma, Latina, Italy
are often comorbid with cognitive disorders, and in adolescents * Corresponding author.
- with affective and behavioural disturbances. Formation of the

AD in children is influenced by pathological types of family rela- Background and aims.– Altered oxysterol levels have been described
tions (split, separated, and rigid relationships). Formation of AD in in patients with numerous neuropsychiatric disorders. Recent
patients of different ages occurs in different ways: in children this studies have shown that Autism Spectrum Disorders (ASD) are
is a constitutional-neuropathic typological variant and in adoles- associated with disruption of cholesterol metabolism. The present
cents a thymopathic variant (depression, fears, obsessive phobias, study aimed at investigating the profile of oxysterols in plasma and
and anxiety) has been established. their association with clinical parameters in ASD patients
Conclusions.– The methodology enables the specialists to determine Methods.– 36 children with ASD and 38 healthy children, matched
the informative markers of the risk of anxiety and depression dis- for age and sex, were included in the study. ASD severity was evalu-
orders development in children, to predict an unfavourable course ated using the childhood autism rating scale. Standard lipid profile,
of the disease, to prescribe the timely differential treatment and to serum glucose, hs CRP, and orosomucoid levels were measured
prevent the AD secondary development in children. utilizing standard techniques; oxysterol levels were measured by
Disclosure of interest.– The authors have not supplied a conflict of isotope-dilution gas chromatography/mass spectrometry.
interest statement. Results.– Standard lipid profile, serum glucose, high-sensitive C-
reactive protein and orosomucoid levels were similar between
the two studied populations. Compared to the control group,
E-PP0202 children with Autism Spectrum Disorders showed a significant
Sleep quality in children with higher plasma level of 24-hydroxycholesterol, while border-
line significance was observed for 7␣-hydroxycholesterol, and
attention deficit hyperactivity
25-hydroxycholersterol. In patients, 24-hydroxycholesterol was
disorder (ADHD) and sensory inversely correlated with age. Multivariate analysis showed that
modulation difficulties high plasma levels of 24-hydroxycholesterol are independent risk
A. Mimouni-Bloch1* , H. Offek2 , R. Tauman3 , S. Rosenblum4 , B. factors for Autism Spectrum Disorders. On the other hand, an
Engel-Yeger4 analysis of the receiver’s operating characteristics proved that the
measured parameters recorded satisfactory levels of specificity and Background and aims.– Inflammation has been advocated as a pos-
sensitivity. sible common central mechanism for developmental cognitive
Conclusions.– The present study provides evidence that Autism impairment such as autism spectrum disorder (ASD). ASD is a devel-
Spectrum Disorders are associated with altered levels in circulating opmental disorder characterized by pervasive deficits in social
oxysterols. The finding that 24-hydroxycholesterol is an indepen- interaction, impairment in verbal and non-verbal communication,
dent risk factor for the disease and suggests the use of this oxysterol and stereotyped patterns of interests and activities.
as a diagnostic tool in Autism Spectrum Disorders. The aim of this study was to evaluate the inflammatory profile in
Disclosure of interest.– The authors have not supplied a conflict of Tunisian children with ASD.
interest statement. Methods.– This was a case–control study conducted at the depart-
ment of child psychiatry. Forty children with ASD diagnosed
according to the DSM-V criteria of the American Psychiatric Asso-
E-PP0204 ciation were recruited. Controls included 43 sexe and age-matched
Lipid peroxidation markers in randomly selected healthy children of the same socioeconomic
children with autism spectrum status. High Sensitive C-Reactive Protein and orosomucoid was
measured for all subjects by immunoturbidimetric method (cobas
disorders (ASD)
6000). The level P < 0.05 was considered as the value for significance
G. Sahar1 , M. Messedi1 , M. Naifar2 , W. Guidara1 , R. Makhlouf2 , D.
Results.– The mean age for autistic versus control children was
Ben touhemi3 , M. Chtourou2 , I. Hadj kacem3 , H. Ayedi3 , Y.
4,78 ± 0,93 versus 4,76 ± 1,08, respectively. Children with ASD
Moalla3* , F. Ayadi2
1 Unit of research “Molecular Bases of Human Diseases, Faculty of did not show significant variation compared to controls for oro-
somucoid concentrations (0.77 ± 0.36 g / L vs. 0.76 ± 0.29 g / L,
Medicine- University of Sfax, Sfax, Tunisia; 2 University of Sfax &
p > 0,05) and High Sensitive C-Reactive Protein (0.94 ± 4.05 mg / L
Habib Bourguiba Hospital. Sfax- Tunisia, Laboratory of Biochemistry,
vs. 0.58 ± 1.23 mg / L, p > 0.05).
Sfax, Tunisia; 3 University of Sfax&HediChaker Hospital, Department
Conclusions.– A considerable body of evidence has demonstrated
of Child and Adolescent Psychiatry, Sfax, Tunisia
* Corresponding author. that inflammatory response has an important role in the patho-
physiology of ASD. In our population, high-sensitive C-reactive
Background and aims.– Autism spectrum disorder (ASD) is a neu- protein and orosomucoid levels were similar between the two stud-
rodevelopmental disorder. It’s behaviorally defined by social and ied populations. A larger population is needed to fully understand
communication impairments and restricted interests and repet- the pathophysiology of ASD.
itive behaviors. In recent years, a potential role of the oxidative Disclosure of interest.– The authors have not supplied a conflict of
stress has been highlighted in the pathogenesis of neuropsychi- interest statement.
atric disorders such as ASD. Several studies suggest that high levels
of lipids oxidation may be contribute to development of ASD. The
aims of this study were to evaluate the plasma and erythrocyte lev- E-PP0206
els of lipid peroxidation markers and to determine their potential Autism spectrum disorder, OCD or just
roles in ASD pathophysiology in Tunisian population. an adolescent. The substrate
Methods.– 42 children clinically diagnosed with ASD using the Diag- underneath bullying
nostic and Statistical Manual for Mental Disorders (DSM-5) criteria G. Montero* , I. Alberdi, M. Pérez Lombardo, F. García-Escribano, J.
were included in the study. As controls, 43 healthy children age Pemán, J.E. Ibáñez
and sex matched, without any known genetic/developmental dis- Hospital Clínico San Carlos, Instituto de Psiquiatría y Salud Mental,
order were recruited. Standard lipids Profile and inflammatory Madrid, Spain
markers, were measured utilizing standard techniques. The malon- * Corresponding author.
dialdehyde (MDA) and conjugated dienes levels were determined
in plasma and erythrocyte as oxidative lipids biomarkers, using Background and aims.– The reason for consultation “bullying” is one
colorimetric methods. of the most frequent in the referrals from Pediatrics and Primary
Results.– Compared to the control group, children with ASD have Care to Child and Adolescent Mental Health Units. However, the
significantly higher plasma and erythrocyte levels of malondialde- diversity of diagnoses received by these patients, if they have any
hyde and conjugated diénes. Standard lipids profile,inflammatory mental disorder at all, is enormous. We present the case of a 16-
parameters were similar between the two studied population.A year-old adolescent who has been followed-up from the age of 11
Receiver Operating Characteristics (ROC) analysis proved that high due to “bullying” and symptoms described as follows.
plasma levels of MDA are predictive markers for ASD diagnosis. Methods.– Psychopathological examination: peculiar contact, elu-
Conclusions.– The present study suggested that ASD may be associ- sive, crestfallen, blink and mouth tics, postural rigidity. Obsessive
ated with higher levels of lipid peroxidation suggesting a potential ideas lived as absurd in relation to contamination with compulsive
role for MDA as a good predictive marker for early diagnosis and as acts of hand washing.
an important player in the pathophysiology of ASD. The only pharmacological treatment our patient has received dur-
Disclosure of interest.– The authors have not supplied a conflict of ing the 5-year follow-up is fluoxetine up to 40 mg per day, with
interest statement. progressive remission of almost every symptom.
Strenghts and Difficulties Questionnaire (SDQ): family: 15; patient:
27; Symptom CheckList (SCL-90-R): very high in all scales. Not
E-PP0205 valid. ADOS-2 Test (Autism Diagnostic Observation Schedule 2):
Inflammatory response in autism borderline classification between ASD and non-ASD.
spectrum disorders Results.– For the clinical evolution, persisting only social isola-
R. Makhlouf1 , M. Naifar1 , M. Chtourou1 , S. Grayaa2 , I. Hajkacem3 , tion, emotional indifference, peculiar interests (not restricted) and
D. Ben Touhemi3 , A. Chaabouni1 , H. Ayedi3 , F. Ayedi1 , Y. Moalla3* having reasonably ruled out the presence of an autism spectrum
1 Habib Bourguiba Hospital, Biochemistry Laboratory, Sfax, Tunisia; 2 disorder; we opted for the diagnosis of a predominantly schizoid
University of Sfax - Medical School, Research Unit in Molecular Basis personality still in development on which have been nesting differ-
of Human Pathology UR 12ES17, Sfax, Tunisia; 3 Hedi Chaker ent symptoms (psychotic, depressive and obsessive-compulsive) in
Hospital, Child Psychiatry Department, Sfax, Tunisia response to external stressors.
* Corresponding author. Conclusions.– Under “bullying” we find a florid and variable symp-
tomatology. It is extremely important to avoid diagnosis such as
Early Onset Schizophrenia or Autism Spectrum Disorder in young Aim.– To Compare Depression, Anxiety, perceived loneliness among
patients with complex symptoms not so very well clarified, for they school going adolescents between hostelers and day boarders.
generally imply pharmacological treatments. Methods.–
Disclosure of interest.– The authors have not supplied a conflict of • The study was conducted among the adolescents in the age group
interest statement. of 11–17 i.e. students from class 6 to class 11.
40 students were hostellers and 40 students were day boarders,
age matched.
E-PP0207 Only male children
The mediating role of children’s Scales applied are the UCLA Loneliness Scale, Screen for child
perfectionism in the association anxiety related disorders (SCARED, child version), 11- Item
Kutcher Adolescent Depression Scale: KADS 11.
between mindful parenting and
Results.–
children’s well-being • Significant difference has been found as per the chi square test
H. Moreira1* , B. Maia2 in the scores of SCARED, and sub scores of SCARED in the form of
1 University of Coimbra, Center for Research in Neuropsychology and Panic disorder, Generalized Anxiety disorder, School avoidance,
Cognitive-Behavioral Intervention, Coimbra, Portugal; 2 The Catholic social anxiety. The scores are higher for the students living in
University of Portugal, Faculty of Philosophy and Social Sciences- hostel.
Braga Regional Centre., Braga, Portugal • No difference has been found for seperation anxiety disorder.
• Similarly the score for KADS and UCLA is higher among hostelers.
Background and aims.– Although scarce, there is some evidence Conclusions.–
• The study poses additional challenges for students’ support
that parental practices are associated with the development of
children’s perfectionism. Mindful parenting, a parental approach services delivery which may require addressing mental health
characterized by the practice of bringing mindful awareness to problems along with common health strategies for the students.
parent-child interactions, is associated with several positive psy- The study results warrants need for interventions like social and
chosocial outcomes in children. However, no study examined psychological support to improve the quality of life for the stu-
whether it is associated with children’s perfectionism. dents. Student advisors and counselors may train students about
Objectives.– To explore whether mindful parenting can contribute stress management.
to lower levels of children’s perfectionism and, therefore, to higher Disclosure of interest.– The authors have not supplied a conflict of
levels of children’s well-being. interest statement.
Methods.– A sample of 222 mother-child dyads (56.3% girls;
Mage = 11.97 years, SD = 2.91, range = 8–18 years) was collected in
a public school in central Portugal. Mothers completed the Inter- E-Poster Presentation: Child and Adolescent
personal Mindfulness in Parenting Scale and children completed
the Child and Adolescent Perfectionism Scale and the Kidscreen-
Psychiatry - Part VII
10 index. The indirect effect of mindful parenting on children’s
well-being through perfectionism (socially prescribed perfection-
ism and self-oriented perfectionism) was explored through the E-PP0209
Process macro for SPSS. Children’s age was introduced as a covari- Baseline brain perfusion in
ate. adolescents with major depression
Results.– Higher levels of mindful parenting were associated with
following a short cognitive behavioral
higher levels of children’s well-being only through lower lev-
els of socially prescribed perfectionism (point estimate = .036, group intervention
95%BcCI = [.002, .100]), in a model explaining 30.26% of the chil- Z. Sosic-Vasic1* , B. Abler1 , P. Plener2 , J. Straub3
1 University Clinic of Ulm, Psychiatry and Psychotherapy, Ulm,
dren’s well-being variance.
Conclusions.– Mindful parents seem to help their children to be less Germany; 2 University Clinic of Vienna, Child and Adolescent
perfectionists, particularly to feel less pressured by others to be Psychiatry and Psychotherapy, Vienna, Austria; 3 University Clinic of
perfect, and consequently, to experience greater well-being. One Ulm, Child and Adolescent Psychiatry and Psychotherapy, Ulm,
fey feature of mindful parenting is the non-judgmental acceptance Germany
of children’s shortcomings and limitations, which seem to protect
them from developing maladaptive perfectionism. Background and aims.– While major effort has been put invested in
Disclosure of interest.– The authors have not supplied a conflict of investigating the neural correlates of depression and their mod-
interest statement. ulation by treatment in adults, less is known about the neural
correlates of psychotherapy in adolescents. The present study is
among the first investigating neural correlates of psychotherapeu-
E-PP0208
tic effects in adolescent patients with major depressive disorder
Depression, anxiety, perceived (MDD). We aimed at applying a rather new und non-invasive
loneliness among school going magnetic resonance imaging technique based on perfusion images
adolescents- a comparative study obtained with continuous arterial spin labelling (CASL).
between hostelers and day boarders Methods.– We investigated regional cerebral blood flow at rest
S. Mudgal (rCBF) in 21 medication-naive adolescents with MDD using CASL.
P.G. Resident, Psychiatry, Indore, India Participants were scanned before and after five 90 minutes ses-
Background and aims.– It is a globally accepted fact that during sions of a cognitive behavioural therapy (CBT) group intervention,
adolescence a child goes through a lot of changes physically, emo- or before and after five weeks of waiting with treatment as usual.
tionally and socially. These changes have a great impact on them; Group assignment was randomized.
they can either make or break an individual. Results.– A comparison of imaging data pre-/post the CBT group
Adolescents residing as Day Scholar or Hostelers are socialized and intervention revealed rCBF changes in the dorsolateral prefrontal
natured in totally different situations. cortex (DLPFC), the caudate nucleus and the parietal lobe following
the CBT. A time (post vs. pre) x group (intervention vs. waiting list)
interaction analysis confirmed the increased rCBF in the DLPFC after Background and aims.– Psychiatric comorbidity has a well-
treatment. established effect on functional gastrointestinal disorders such as
Conclusions.– Our findings indicate that non-invasive resting per- functional dyspepsia and irritable bowel syndrome in children and
fusion scanning is suitable to identify CBF psychotherapy-related adolescents, but the relationship between psychiatric disorders and
alterations in adolescent patients with MDD at rest. The observed Gastroesophageal Reflux Disease (GERD) in these age groups is not
rCBF alterations in the reported regions might be associated with studied well.
altered top-down cognitive processing in depressed adolescents Methods.– We performed a questionnaire-based survey of 173
following CBT. urban Siberian (Krasnoyarsk, Russia) adolescents aged 12–18 using
Disclosure of interest.– The authors have not supplied a conflict of the Russian version of Gastroesophageal Reflux Disease Ques-
interest statement. tionnaire (GerdQ) and computer-assisted DAWBA package of
interviews [J Child Psychol Psychiatry. 2000; 41: 645–655]. The sum
of the scores for the six GerdQ questions ranged from 0 to 18 and
E-PP0210 was defined as the GerdQ score, with a score ≥ 8 indicative of high
Risk factors influencing severity of probability for GERD. Each of psychiatric disorders was coded on
attention deficit hyperactivity a computer-generated 5-point probability scale. Data are shown
as Mean (Mean–SE-Mean + SE) of computer-predicted probability.
disorder in a sample of preparatory
The Kruskal-Wallis test was used to determine differences between
school students in cairo groups.
M. Sultan1* , H. Ramy1 , M. EL Sheikh2 , R. Bassim1 , M. Eid3 , R. Ali1 , Results.– Significant positive associations were detected between
M. El Miissiry1 GERD presence and depressive disorder (Table 1). Notably, the
1 Institute of Psychiatry- Ain Shams University, Neuropsychiatry,
probability of a depressive disorder increased with the impact
Cairo, Egypt; 2 Institute of Psychiatry Ain Shams University, of GERD on daily life. No associations were revealed between
Neuropsychiatry, Cairo, Egypt; 3 Institute of Psychiatry- Ain Shams GERD-related symptoms and anxiety, phobias, posttraumatic stress
Universty, Neuropsychiatry, Cairo, Egypt disorder and obsessive-compulsive disorder.
Table 1. Psychiatric comorbidity in adolescents with gastroe-

Background and aims.– Attention deficit hyperactivity disorder sophageal reflux disease
(ADHD) is one of the most common childhood psychiatric disorders.
Severity of symptoms is associated with more behavioral prob-
lems, poor academic performance, and persistence of symptoms
into adulthood.
Aim.– To examine the clinical and social correlates that may be iden-
tified as risk factors associated with ADHD severity in a sample of
adolescent ADHD school students.
Methods.– A total of 925 students were recruited from two
public and two private schools from eastern Cairo. They were
interviewed using Conners-Wells Adolescent Self-Report—short
version (CASS-S); students scoring more than 65 were fur-
ther interviewed with Kiddie Schedule for Affective Disorders
and Schizophrenia—present and lifetime version (K-SADS-PL)
to confirm the diagnosis, then Conners-Wells Adolescent Self-
Report—long version (CASS-L) to assess severity and Wechsler
Intelligence Scale for Children (WISC) to ascertain intellectual abil-
ity. Conclusions.– These results indicate that some psychological symp-
Results.– About 10.3% of cases were severe, 5.7% were moder- tomatologies, such as depressive disorder, are positively associated
ate, and 83.9% were mild. Severity was significantly associated with GERD-related symptoms in urban adolescents. We suggest
with female gender, psychiatric comorbidity, family problems, that chronic stress may lead to acid overproduction and violation of
conduct symptoms, and poor anger management. Diagnostic gastrointestinal motility and visceral sensitivity. High probability of
and Statistical Manual of Mental Disorders (4th ed.) (DSM-IV) depressive disorder should be taken into account when evaluating
hyperactive–impulsive type was the only predictive factor of ADHD the adolescents with GERD.
severity. Disclosure of interest.– The authors have not supplied a conflict of
Conclusions.– The diagnosis of hyperactive–impulsive subtype may interest statement.
predict the severity of ADHD symptoms.
interest statement. E-PP0212
Prevalence of mobile phone
E-PP0211 dependence among undergraduates
The development and well-being students of bpkihs, dharan
K. Thapa
assessment (DAWBA) screening for B.P. Koirala Institute of Health Sciences, Department of Psychiatric
psychiatric comorbidity in Nursing, Dharan, Nepal
adolescents with gastroesophageal Background and aims.– The charm of mobile phone is more among
reflux disease young generation and the increasing use can lead to various harm-
S. Tereshchenko* , N. Gorbacheva, M. Shubina ful effects and may result in dependence. The objective of the study
Scientific Research Institute of Medical Problems of the North, is to assess the prevalence of mobile phone dependence among the
Department of Child’s Physical and Mental Health, Krasnoyarsk, undergraduate students of BPKIHS, Dharan.
Russia Methods.– A descriptive cross sectional study was conducted on
* Corresponding author. a total of 390 undergraduate students of BPKIHS, Dharan aged
between 17 and 25 years who were using mobile phones for more
than 1 year by using stratified propionate sampling technique. Stu- E-PP0214

dents were requested to complete a pre tested self administered ‘Becoming dad’: a qualitative study
questionnaire which comprised their socio-demographic charac-
about the search for meanings of
teristics, pattern of mobile phone usage and a standard 17 items
Mobile phone addiction index.
fatherhood by brazilian adolescent
Results.– Among the total 390 students, all of them had their own fathers
smart phones. The average time spent by the students on the mobile J. Vasconcellos, D.B. Faria-Shutzer, F.G.C. Surita, E.R. Turato*
phone was 4.08 hrs. Majority of the students (67.4%) use mobile State University of Campinas, Laboratory of Clinical-Qualitative
phones at night. The median amount of money spent on recharge Research LPCQ, Campinas, Brazil
per month was 500. The prevalence of mobile phone dependence
among the undergraduate students was found to be 21.8%. Mobile
Background and aims.– Many researches study adolescent mothers,
phone dependence was found to significantly associated with time
but few consider adolescent fathers. They are especially relevant
spend on mobile; calls per day, money spend on recharge per month
for clinical practioners when attend pre-natal appointments with
and years of ownership of mobile phone.
their pregnant partners, because they are available for interven-
Conclusions.– The results of this study gives an alarming indication
tional actions. To understand their life experiences may contribute
that as days goes by the youth are getting more and more dependent
to better approach this population.
on mobile phones, which can be associated with different aspects
We aimed to explore emotional meanings about fatherhood among
or problems of mental health.
adolescent fathers seen at a public outpatient service.
Methods.– We used the clinical-qualitative method to be applied in
interest statement.
assistance setting. We in-depth interviewed 14 adolescent fathers
attending spontaneously with their pregnant adolescent partners
E-PP0213 at a prenatal outpatient of university woman hospital. We used the
trigger question: “Tell me how the experience with the pregnancy
Investigation of omega-6/omega-3 is for you”. We did also field diaries. We used theoretical saturation
fatty acids in children with depressive to build the sample. Data analysis followed steps-structured model
disorder and health psychology was the theoretical approach.
J. Trebatickà1* , Z. Matzova1 , Z. Hradečna1 , I. Guschina2 , I. Results.– As result, we raised 4 categories. (1) “Me, father?!”: con-
Garaiova3 , J. Šuba4 , Z. Ďuračkova5 ceptions about fatherhood; (2) Imaginary relationship with the
1 Comenius University- Faculty of Medicine, Department of Child and
baby; (3) Pregnancy and new dynamics in the relationship with
Adolescent Psychiatry, Bratislava, Slovak Republic; 2 Cardiff the pregnant adolescent; (4) Influence of social circles for the con-
University, School of Bioscience, Cardiff, United Kingdom; 3 Cultech stitution of fatherhood: the original family and friends.
Ltd, Research and Development Department, Port Talbot, United Conclusions.– There are several emotional experiences, with per-
Kingdom; 4 National Institute of Children’s Diseases, Department of sonal, familiar and social aspects influencing the adolescents’
Child and Adolescent Psychiatry, Bratislava, Slovak Republic; 5 conception about fatherhood. Theu desire to maintain participatory
Comenius University- Faculty of Medicine, Institute of Medical bonding in child care and report affective relationships with the
Chemistry- Biochemistry and Clinical Biochemistry, Bratislava, Slovak pregnant adolescents. Parenting can be catalyst for positive change,
Republic releasing them into adulthood. Health professionals include them
in prenatal care, to encourage them to share responsibility for the
child, support the adolescent pregnant woman, and family and pro-
Background and aims.– The prevalence of mood disorders in chil- fessional planning.
dren has an increasing trend. Omega-3 fatty acids (FA) are shown Disclosure of interest.– The authors have not supplied a conflict of
as a promising adjuvant treatment of depressive disorder in chil- interest statement.
dren. The primary objective of this pilot, single-centre, randomized,
double-blind controlled study was to investigate the levels of
Omega-3 and Omega-6 FA in serum and their ratio in children with E-PP0215
depression before and after fish oil emulsion administration.
ADHD symptoms, chronotype and
Methods.– 41 children (11 to 17 years) were randomised 1:1 to the
Omega-3 FA or Omega-6 FA groups. Patients were clinically inves- obesity in children and adolescents
tigated with CDI score (Children’s Depression Inventory) every S. Turkoglu1* , F.H. Çetin2
1 Selçuk University School of Medicine, Department of Child and
two weeks during 12 weeks of intervention. The levels of omega-
3 (eicosapentaenoic acid- EPA, docosahexaenoic acid-DHA) and Adolescent Psychiatry, Konya, Turkey; 2 Selçuk University School of
omega-6 FA in serum were determined by capillary FID-gas chro- Medicine, Department of Child and Adolescent Psychiatry-, Konya,
matography. Turkey
Results.– CDI scores decreased after the omega-3 FA supplemen-
tation by 27% compared to omega-6 FA (13%). The EPA and DHA Background and aims.–The risk for obesity is increased in child
levels were lower in depressed children, unlike in 20 healthy chil- and adolescents with attention-deficit / hyperactivity disorder
dren. After supplementation with omega-3 FA, the level of EPA has (ADHD). The potential mechanisms underlying this correlation are
risen to 500% and DHA to 250% of the original values. The omega- ambiguous. ADHD has been linked with disturbances in chrono-
6/omega-3 ratio was 25.5: 1 for depressed children and 18: 1 for type, especially rised eveningness. Here, we aimed at identifying
the control group (p = 0.021). After 6-week omega-3 supplementa- the factor contributing to the comorbidity between ADHD and obe-
tion, the omega-6/omega-3 ratio was reduced to 8.8: 1 (p < 0.0001), sity, including chronotype.
unlike in omega-6 supplementation where the omega-6/omega-3 Methods.– The study sample consisted of 70 treatment-naive chil-
ratio remained unchanged (24.5: 1). The ratio omega-6/omega-3 dren with ADHD aged 7–17 years. The ADHD module of the Kiddie
positively correlated with CDI score (p = 0.003). Schedule for Affective Disorders and Schizophrenia-Present and
Conclusions.– The omega-3 FA could be a suitable adjuvant therapy Lifetime Version was used to diagnose ADHD. The severity of ADHD
for reducing the severity of depression and the omega-6/omega-3 symptoms was assessed via Conners’ Parent Rating Scale (CPRS).
FA ratio. (APVV-grant 15-0063) Questionnaire and Children’s Chronotype Questionnaire were used
Disclosure of interest.– The authors have not supplied a conflict of for the evaluation of chronotype in children with ADHD.
interest statement.
Results.– The rate of overweight/obese children was 31.4% (n = 22) Background and aims.– The aim of this study was the analysis of
in the children with ADHD. The BMI percentile score had a posi- dynamics of motor cortex metabolite in the norm and in early stage
tive corelation with the children’s choronotype questionaire score of schizophrenia in period of BOLD response to event related single
and cognitive problem/inattentive subscore of CPRS. We found stimulus.
that overweight/obese children with ADHD had more eveningness Methods.– The patient group comprised 9 males aged from 16 to
Chronotype compared with the normal weight group. 28 years who met the criteria of schizophrenia (F20, ICD-10). Study
Conclusions.– These findings highlight possible reciprocal links was performed on clinical Phillips Achieva 3.0 T MRI scanner. VOI
between ADHD symptoms, BMI percentile score and chronotype in motor cortex was localized on the base of fMRI study (EPI FFE,
in children aged 7–17 years, which might lead to individualized TR = 3000 ms, TE = 30 ms).
treatment options. Results.– The BOLD signal in both groups demonstrated maximum
Disclosure of interest.– The authors have not supplied a conflict of at the 6th s after target stimulus, however its value was reliably
interest statement. lover in schizophrenia in comparison with the control group. The
only [NAA] in normal motor cortex was changed after the stimula-
tion. In schizophrenia [NAA], [Cr] and [Cho] were constant. [NAA]
E-PP0216 in normal cortex statistically significantly decreased at the 12th s
Dysfunction of microstructure and after stimulus presentation and returned to initial value at the 15ths
metabolism in corpus callosum in (figure 1).
juvenile schizophrenia
M. Ublinskiy1* , P. Menshchikov1 , A. Manzhurtsev1 , T. Akhadov1 , N.
Semenova1 , I. Lebedeva2
1 Clinical and Research Institute of Emergency Pediatric Surgery and
Trauma, Radiology, Moscow, Russia; 2 Psychiatry- National Mental

Health Research Centre of the Russian Academy of Medical Sciences,
Psychiatry, Moscow, Russia
Background and aims.– The aim of the study was to analyze the
microstructural and metabolic features of the corpus callosum in
recently onset schizophrenia.
Methods.– The study was carried out in 13 men with juvenile
endogenous paroxysmal psychosis (disease standing ≤ 5 years after
first manifestation) aged 17–27 years (median 22.0 ± 3.1 years). Figure 1. NAA and bold dynamics.
Control group consisted of 15 mentally healthy young men (18–28
years). Studies by MRI and 1H-MRS were carried out on Achieva Conclusions.– The reversible decrease of NAA observed for the norm
3T MRI scanner (Phillips). The spectroscopic voxel (2 × 1 × 1 mm) in the study could provide a short-term activation of neuronal Krebs
was placed in the CC knee region. The PRESS sequence was used cycle through a synthesis of Ac CoA using acetate obtained in ASPA
(TR/TE = 1500/40 msec). reaction. Different behavior of [NAA] in the norm and schizophrenia
Results.– In patients, increased ADC (p = 0.02) and RD (p = 0.008), might be related with a difference in location (or activity) of ASPA.
decreased FA (p = 0.008) and NAA (p = 0.03) were found in the cor- Decreased expression of glutamate transporters in schizophrenia
pus callosum genu, No intergroup differences by PD, Cho, Cr, Glx could also reduce consumption of NAA as a source of acetate in
were found in this area. Also, no statistically significant intergroup synthesis of Ac CoA which is used for restoration of ATP.
differences were observed for the DTI and MRS characteristics of Disclosure of interest.– The authors have not supplied a conflict of
the corpus callosum splenium. interest statement.
Conclusions.– Comparison of our DT-MRI and 1H-MRS data on the
CC knee showed that the increase of RD in patients with early
schizophrenia did not conform to active demyelination, which was E-PP0218
proven by the normal level of Cho, while axon damage, shown by Malfunction of diffusion parameters
low level of NAA, did not lead to PD reduction. The decrease of NAA in the corticospinal tract of patients
level detected in our study indicated axonal damage in the CC knee with early stage of schizophrenia
of patients with the early stage of schizophrenia. The increase of RD M. Ublinskiy1* , A. Manzhurtsev1 , P. Menshchikov1 , T. Akhadov1 , N.
in the presence of normal Cho level seemed to indicate disorders Semenova1 , I. Lebedeva2
in the axon cytoskeleton damage, but not active demyelination. 1 Clinical and Research Institute of Emergency Pediatric Surgery and
Disclosure of interest.– The authors have not supplied a conflict of Trauma, Radiology, Moscow, Russia; 2 Psychiatry- National Mental
interest statement. Health Research Centre of the Russian Academy of Medical Sciences,
Psychiatry, Moscow, Russia
E-PP0217
NAA and bold dynamics after single Background and aims.– Among various neurobiological models of
short stimulus in motor cortex of schizophrenia, much attention is paid to structure and microstruc-
schizophrenia patients ture disturbances in brain white matter. The aim of this study
M. Ublinskiy1* , A. Manzhurtsev1 , P. Menshchikov1 , N. Semenova1 , is to research the most important pyramid pathway of the brain
T. Akhadov1 , I. Lebedeva2 responsible for impulse transduction during motion regulation -
1 Clinical and Research Institute of Emergency Pediatric Surgery and corticospinal tract (CST) - using method of diffusion tensor imaging
Trauma, Radiology, Moscow, Russia; 2 Psychiatry- National Mental (DTI).
Health Research Centre of the Russian Academy of Medical Sciences, Methods.– The study was done in accordance to the Code of Ethics
Psychiatry, Moscow, Russia of the World Medical Association (Declaration of Helsinki) for
* Corresponding author. experiments involving humans. All participants signed an informed
consent. 13 young (17 -27) male patients with schizophrenia (F20,
ICD-10) and 15 mentally healthy age- and sex-matched subjects E-PP0220

were analyzed. MRI data were obtained on Achieva 3.0T scanner Cognitive, emotional and psychosocial
(Philips) with DualQuasar gradient system and 8-channel radio-
avatar reinforcement program: cesar
frequency receiver coil for the head. DT-images were acquired
in the axial plane using echoplanar impulse sequence. Diffusion
as co-therapist in
gradient were applied in 32 non-collinear directions. Functional neurodevelopmental disorders,
anisotropy (FA) and diffusion coefficient (DC) were measured in emotional dysregulation,
the following parts of CST in left and right hemispheres: motor area, immigration and transculturally in
radiate crown, posterior limb of internal capsule, cerebral peduncle, children & adolescents
pyramids of the medulla oblongata.
A. Vargas Castro
Results.– A decrease in the coefficient of fractional anisotropy in the
Fondation Santé des Etudiants de France, Child & Adolescent
posterior limb of the internal capsule and an increase in diffusion
Psychiatry, Neufmoutiers-en-Brie, France
coefficient in the radiate crown and motor cortex were observed. * Corresponding author.
Conclusions.– The results reflect different mechanisms of changes in
water diffusion in various areas of the corticospinal tract: changes Background and aims.–
in nerve fiber microstructure in internal capsule (left hemisphere) Objectives.– Demonstrate the good results of the psychotherapeutic
and density decrease in motor cortex and radiate crown. approach for children with neurodevelopmental disorders through
Disclosure of interest.– The authors have not supplied a conflict of the prepositioning of general functioning levels, the adjustment of
interest statement. group therapy and the graphic support of stories.
Methods.– It is an observational pilot study of therapy based on the
project of individual care of six children between 5–6 years old.
E-PP0219 They have an ASD diagnosed by ADI-R,ADOS & CARST,without a
Inductive effects of phenytoin as a moderate to greater deficit in cognitive ability, all of whom partic-
pediatric epileptic drug on gingival ipated in 12 sessions (sometimes with their siblings and their two
fibroblasts parents) of training programs with two therapists.
S. v1* , B. Nazemi2 Interventions were based on the positive reinforcement thanks
1 Shahid Beheshti University of medical sciences, Perio, Tehran, Iran; to caricature characters representing each child and their fam-
2 ZUMS, Pedodontics, Zanjan, Iran ily,emotional expressing, social skills and adapted behaviors.
* Corresponding author. Social Skills Rating necessary for Interpersonal relations (EHSRI)
was used to evaluate generalization with parents and Quantitative
Background and aims.– Gingival Overgrowth (GO) is a well- evaluation was carried out before the training program and at the
documented and unwanted side effect that occurs mainly as a result last session.
of certain anti-seizure, phenytoin. Recent studies have demon- Results.–
strated that deregulated cytokine production of fibroblast may Results & conclusions.– Our findings highlighted an increase in the
contribute more significantly in development and maintenance of total score of social and emotional skills following the training ses-
GO. According to epidemiologic studies, age is an important predis- sions. ADOS and CARST give better results in the objectivation of
posing factor, and GO is observed at a higher prevalence in children symptoms.
and adolescents. The aim of this study was to compare the effect Children were more interactive between them, identifying each one
of phenytoin on proliferation and production of IL1␤ and PGE2 in with his avatar and more spontaneous with their partners.
cultured human gingival fibroblasts (HGF) of children and adults. CESARprogram is an excellent intervention in transdisciplinary
Methods.– Normal HGFs were obtained from 4 healthy children and teamwork with children an Autism Spectrum Disorder,specifically
4 adult and then were cultured with phenytoin (20 mg/ml). MTT in stimulating social communicative development.
test was used to evaluate the proliferation and ELISA to determine The results would have more scientific validity with an enlarge-
the level of IL1␤ and PGE2 production by HGFs. Analysis of prolif- ment of the sample.
eration were assessed by Independent T-Test and ANOVA analysis Conclusions.– CESAR program is an excellent co-therapist with dif-
was used to assess the level of IL1␤ and PGE2 production with an ferent approaches and the positive results for the patients, their
a error level less than 0.05. families and psychoeducation process.
Results.– The proliferation of HGF was not affected significantly by Disclosure of interest.– The authors have not supplied a conflict of
phenytoin in both cultured fibroblast sources. (P>0.05) Phenytoin interest statement.
induced a significantly higher formation of IL1␤ and PGE2 in child’s
HGFs as compared to adult’s HGFs. (P < 0.05)
Conclusions.– The results suggest that different inflammatory E-PP0221
responces and cytokine formation by child’s and adults HGFs are A qualitative service review and
probably the key elements that cause different reaction of pheny- service user feedback of dialectical
toin therapy. Although more advanced and systematic studies are
behavioural group therapy for
needed to verify these fibdings about the pathogenesis of GO in
different age. adolescents at the national children
Disclosure of interest.– The authors have not supplied a conflict of and young people service (CYPS) Malta
interest statement. D. Vella Fondacaro* , N. Camilleri
Mount Carmel Hospital- Attard- Malta, Psychiatry, Attard, Malta
Background and aims.– DBT is effective for borderline personality

disorder and targets emotional regulation by teaching cop-
ing/adaptation skills to improve emotional stability.
This study aimed to assess changes in mental state following group
DBT sessions through:
• Qualitative feedback using questionnaire followed by thematic E-PP0223

analysis on patients’ experience attending DBT group skills Impairment of neurological
course. ontogenesis in children with autism
• Outcome measures (CGAS, HoNOSCA, SDQ, M&F).
Methods.–
spectrum disorders
T. Voloshyn1* , V. Kozyavkin2
1. DBT skills sessions carried out on nine adolescents at CYPS 1 Author, Medical Psychology, Truskavets, Ukraine; 2 ICR, Medical
(Malta, July-September 2017). Session feedback forms were
Psychology, Truskavets, Ukraine
filled in to gather ongoing data. * Corresponding author.
2. Patient’s caregivers were contacted approximately six months
following sessions and asked to complete feedback ques- Background and aims.– Autism spectrum disorders (ASD) are not
tionnaire. Consent obtained from every parent/adolescent. A singly related to a psychiatric field. Often changes of motor devel-
thematic analysis was carried out. opment and neurological condition occur that worsen socialization
3. CGAS, HoNOSCA, SDQ (11-17y/o) and M&F questionnaires were of these patients and their quality of life. Frequently patients do
filled in. not communicate with peers because they cannot fulfil tasks that
Results.– Mean attendance within adolescent group was 5.14/9 typically developing children are capable of.
sessions which was similar to parent group (5.28). Parents rated Methods.– 179 patients with ASD (F84.0) were examined using
sessions better through feedback scores (Mean = 9.38 vs the ado- Autism Comorbidity Interview, parent’s questionnaires, neurologi-
lescent group mean = 7.14). Mean adolescent feedback (+1.95) cal examination, dynamometry, Box and Blocks test, and the 9-hole
improved more than mean parent feedback (+0.55) from 1st to last peg test. Patients aged 5 to 14 years, mean age - 7.2 years.
session. From pre to post DBT assessment an improvement was Results.– It was found that only 28.9% of children with ASD had
recorded in HoNOSCA and CGAS scores for all adolescents. 3 out of 4 no comorbid neurological pathology. 34.8% had uni/bilateral pyra-
M&F scores collected also showed improvement. Common themes midal tract insufficiency, 21.9% had perinatal lesion of the Central
emerging from feedback: parking, appearance of clinic, providing Nervous System (F82), 9.9% had Cerebral Palsy (G80), and 9.9% had
evening sessions. epilepsy (G40). 25.7% of patients had an increase of muscle tone in
Conclusions.– Adolescents were more reluctant to attend than par- distal parts of lower/upperlimbs, 18.8% had a decreased range of
ents and gave lower feedback scores, which might reflect the passive motions in the joints of the lower limbs. Fine hand function
current mental state or the level at which the sessions were pitched. was impaired in 45.9% of patients, both manipulative and grasping
However, although a small case sample, results show that there was abilities were worse in comparison to average scores.
a general reduction in psychiatric symptomatology following DBT Conclusions.– Changes in neurological state in patients with ASD
sessions. are common. There is an acute necessity to identify and code
Disclosure of interest.– The authors have not supplied a conflict of them accordingly. This will benefit complex treatment approach
interest statement. for these patients. Indicates the necessity for the rehabilitation of
ASD patients it to be multidirectional.
E-PP0222
interest statement.
Risk-taking behaviours related to
internet use in adolescence
M.F. Vieira1* , J. Sanchez2 E-PP0224
1 Department of Child and Adolescent Psychiatry- Dona Estefânia Obsessive-compulsive disorder: a
Hospital- CHLC- Lisbon- Portugal, Child and Adolescent Psychiatry, descriptive study of 17 tunisian
Lisbon, Portugal; 2 Hospital Dona Estefânia- CHULC- EPE, Child and
Adolescent Psychiatry, Lisbon, Portugal
adolescent patients
* Corresponding author. A. Wael* , S. Bourgou, B.O. Asma, S. Lina, H. Mariem, C. Fatma, B.
Ahlem
Background and aims.– The use of Internet is leading to many risk- Monji Slim Hospital, Child and Adolescent Psychiatry Department,
taking behaviors between adolescents. Internet communication Marsa, Tunisia
has become an important way of social interaction (and probably
one of the main) between teenagers.
Background and aims.– Obsessive-compulsive disorder (OCD) is a
The authors intend to review the type of risk-taking behaviors
frequent disorder, however it has been poorly studied in children
related to internet use among adolescents, describe the principal
and adolescents in Tunisia.
risks and consequences and evaluate what can be done to prevent
The aim of this study is to describe demographic and clinical charac-
these behaviors.
teristics in a sample of Tunisian adolescent patients with a principal
Methods.– For this presentation, a non- systematic search of pub-
diagnosis of OCD.
lished literature from January 2005 and December 2018 was carried
Methods.– A retrospective study of 17 adolescent patients referred
out, through PubMed, using the following key words: “adoles-
to the department of child and adolescent psychiatry at Mongi
cents”, “internet” and “risk” and “behaviour”.
Slim hospital in Tunis (Tunisia). The DSM-5 OCD criteria and the
Results.– Adolescents have several risk-taking behaviors and other
Yale–Brown Obsessive Compulsive Scale were used.
related problems while using the internet. There is evidence that
Results.– The mean age was 14 years old. The sex ratio was 0.5.
these kind of behaviors happen more frequently among adolescents
A triggering factor was found in 53% of the cases. Contamina-
who lack parental supervision and who have other risk factors.
tion was the most prevalent obsession, followed by death fear.
Conclusions.– Several studies suggest that adolescents have risky
Washing/cleaning was the most common compulsion followed by
behaviors on the Internet. The consequences can be detrimental
checking and ordering rituals. Comorbidity was present in 64.7%
to their development. There is an urgent need to educate parents,
of the patients, forty-seven percent of referred adolescents had a
teachers, and address this issue on a greater scale including at the
depressive disorder and 23.5% had an anxiety disorder. Seventy
policy level. All health care providers need to be informed of Inter-
percent of the subjects had an important impact on their social
net behaviors in order to assess for children at risk and to intervene
life and school results, family conflicts, social withdrawal and poor
and to educate adolescents, teachers and parents.
school performance were the most common consequences. Forty-
one percent of the subjects had a pharmacological treatment and
interest statement.
a cognitive behavioral therapy, forty-one percent had only psy- E-Poster Presentation: Classification of mental
chotherapy and 18% had only pharmacotherapy. disorders / Research Methodology - Part I
Conclusions.– Obsessive-compulsive disorder is a distressful dis-
order that has a serious impact on adolescent’s quality of life.
Depressive and anxiety disorders are very commonly associeted.
Disclosure of interest.– The authors have not supplied a conflict of E-PP0226
interest statement. Relationship of psychological
problems with life satisfaction and
E-PP0225
optimism among students of
Community multi-discipline youth university of Karachi, Pakistan
S. Ali1* , A.A. Malik2
treatment programme 1 University of Leicester, Department of Neuroscience- Psychology
T. Wilkes1* , I. ortega2 , C. Tortorelli3 , T. Basi4 , R. Kent5 and Behaviour, Leicester, United Kingdom; 2 University of Karachi-
1 University of Calgary, Psychiatry, Calgary, Canada; 2 Alberta Health Pakistan, Department of Psychology, Karachi, Pakistan
Services, Psychiatry, Calgary, Canada; 3 Child Family Services- * Corresponding author.
Alberta, Child Welfare, Calgary, Canada; 4 Wood’s homes, Director of
Wood’s Homes, Calgary, Canada; 5 Alberta Health Services, Child Background and aims.– Students are the essential asset of any coun-
Adolescent Mental Health and Addictions Psychiatry Programme, try who plays the great role in driving the country towards big
Calgary, Canada achievements Numerous studies demonstrated the psychological
problems faced by students of university. Nonetheless, much work
has not been through in Pakistan with respect to psychopathology
Background and aims.– The youth community support programme and its influence on their well-being. Present study is an attempt
in Calgary, Canada is a cross ministry initiative that aims to provide to explore the relationship between Psychopathology and its effect
a step down service for youth and their families who are dis- on student’s Life satisfaction and Optimism. Gender difference with
charged from patient mental health placements.A trans disciplinary reference to psychopathology was also investigated.
approach has been utilized wrap around services for a number of Methods.– It is a cross sectional study. Sample of 400 participants
youth. YCSP serves youth aged 13–18. had been taken from major representative departments of Human-
Methods.– During May 2015 to January 2018 there were 126 refer- ities, Sciences, Social Sciences, Management and administrative
rals, 55 enrolments and 38 discharges. The medium and mean sciences of University of Karachi. Consent form was got signed from
length of stay were calculated. every participant. Interview sheet and General Health Question-
Similarly the number of emergency health visits: 6 months prior naire: GHQ 28 (assess somatic symptoms, anxiety and insomnia,
to admission, during YCSP stay, and 6 month afterwards were also social dysfunction and severe depression), Satisfaction With Life
calculated. Scale (SWLS) and Life Orientation Scale (LOT) were administered
This process was replicated for calculating impatient mental health on each participant.
admissions prior during and after YCSP. Results.– Analysis of data done on Statistical Package for The Social
Subsequently the number of mental health bed days were also esti- Science SPSS-13 V. Findings specifies that the mean and standard
mated. deviation of most of the variables are encouraging, the correla-
Additionally the distribution of the diagnostic profiles for all tions between psychological problems and satisfaction with life,
patients were determined. optimism found negatively associated and significant at 0.01alpha
Results.– There was a 98.9% reduction of days in hospital for these level. No significant gender difference was observed in the level of
youth once they were enrolled in the YCSP programme. psychological problems.
The evaluation also indicated youths demonstrated an improve- Conclusions.– Well-being of students determines their quality of
ment in general emotional and behavioural functioning from pre future life. Student with overall better expectations from life, con-
to post treatment as indicated by the CGAS scores. 43% of fami- tentment with their life, are likely to handle challenges in a fine
lies had protective children’ services involvement and 30% had a way. Quality of students’ well-being can become better if we work
psychotic disorder. on students psychological problems.
Quality of life scores for youth and care givers also improved. The Disclosure of interest.– The authors have not supplied a conflict of
mean adverse childhood experience score was 4.9 and at discharge interest statement.
40$ of youth had 5 or more diagnosis.
Conclusions.– This wrap around trans disciplinary approach using a
collaborative cross ministry approach is a successful alternative to E-PP0227
intensive impatient treatment for high risk youth.
Diagnostic instability in psychiatry
B. Côrte-Real1* , P. Câmara Pestana1,2 , T. Duarte1,2 , A. Bonito
interest statement.
Ferreira1,2
1 Santa Maria’s University Hospital – Lisbon’s North Hospital Center,
Psychiatry and Mental Health, Lisbon, Portugal; 2 Faculty of

Medicine- University of Lisbon, Psychiatry, Lisbon, Portugal
Background and aims.– Diagnostic instability is a measure to which

psychiatric diagnoses change over time in the same patient. Since
psychiatric diagnostic categories are developed without biological
markers, the diagnostic process is less reliable in psychiatry than
in other fields of medicine.
The authors aim to study changes in psychiatric diagnoses and the
factors involved.
Methods.– Nonsystematic review of the literature with the follow-
ing search terms: “diagnostic instability”, “diagnostic accuracy”,
“overdiagnosis”, “misdiagnosis” and “diagnostic error”.
Results.– The overall mobility of diagnoses ranged from 27 to E-PP0229

40%. For most studies, the diagnosis with greater instability Missed diagnoses and misdiagnoses of
was schizoaffective disorder, with some authors even defend-
adults with autism spectrum disorder
ing its elimination from the diagnostic classification. On the
other hand, the most stable diagnosis over time is schizophrenia
(ASD)
(mean stability: 90%). The greatest diagnostic shifts move towards L. Fusar-Poli1* , N. Brondino2 , P. Politi2 , E. Aguglia1
1 University of Catania, Department of Clinical and Experimental
schizophrenia with the existence of negative symptoms as the main
contributing factor. Bipolar disorder (BD) revealed the most vari- Medicine- Psychiatry Unit, Catania, Italy; 2 University of Pavia,
able results depending on the study. In some, underdiagnosis is Department of Brain and Behavioral Sciences, Pavia, Italy
the issue, especially when the first episode is depressive or when
psychotic symptoms are present. In fact, approximately 61,5% of Background and aims.– After diagnostic criteria changes,
bipolar patients with psychotic symptoms received a first diagno- researchers are looking for the “lost generation” of adults
sis different from BD. BD may also be overdiagnosed, particularly with autism spectrum disorder (ASD), a condition which affects
in the presence of personality and substance use disorders. about 1% of the population. However, given the overlapping
Conclusions.– In the absence of biological markers, longitudinal val- symptomatology with other psychiatric conditions, diagnosing
idation through a long-term follow-up is necessary for accurate ASD represents a challenge for clinicians. Consequently, people
diagnostic ascertainment. It is believed that family or genetic stud- with ASD may remain undiagnosed or misdiagnosed, not receiv-
ies will become a more reliable tool in error detection as well. ing adequate support. The present study aimed to evaluate the
Disclosure of interest.– The authors have not supplied a conflict of clinical history of subjects who received a first diagnosis of ASD in
interest statement. adulthood.
Methods.– We reviewed the clinical charts of all subjects who
received a diagnosis of ASD in two Italian centres specialized in
E-PP0228
adults with ASD. Diagnoses were confirmed by a team of psychia-
Gaming behavior in portuguese trists with wide expertise in the field, after the administration of
university students standardized tests (e.g. ADOS-2, ADI-R).
A.R. Dores1,2* , A. Geraldo3 , F. Barbosa2 Results.– The sample comprised 129 subjects, of which 91 (70.5%)
1 School of Health- Polytechnic Institute of Porto, Human and Social were males. Mean age at diagnosis was 23.15 years (range 14–55),
Sciences, Porto, Portugal; 2 Faculty of Psychology and Educational with a mean IQ of 99.85 (range 30–145). The first evaluation by
Sciences of University of Porto, Laboratory of Neuropsychophysiology, a mental health professional was performed meanly at the age of
Porto, Portugal; 3 School of Health- Polytechnic Institute of Porto- 14.91 years, with a mean gap of 10.56 years between first evaluation
Faculty of Psychology and Educational Sciences of University of Porto, and diagnosis of ASD. Of note, 36% of subjects had never received a
Human and Social Sciences- Laboratory of Neuropsychophysiology, psychiatric diagnosis. The most common past diagnoses were intel-
Porto, Portugal lectual disability, personality disorders, psychoses and depression,
with differences according to gender.
Conclusions.– Given the prevalence of autism and the high rates of
Background and aims.– Gaming behaviors have been receiving psychiatric comorbidities, it is important for clinicians to consider
increased attention from the scientific community in recent years. ASD in the differential diagnosis process. An accurate identifica-
This phenomenon has accompanied the easier access to betting and tion of ASD also in adulthood is in fact fundamental for outcome
casino-like games, and the establishment of online gaming as an improvement.
important recreational activity, particularly in western societies. Disclosure of interest.– The authors have not supplied a conflict of
Considering the impact that the potential addictive power of games interest statement.
can have in human health and well-being, it seems important to
better know and understand this phenomena.
We aimed to study gaming behaviors in Portuguese univer- E-PP0230
sity students. Additionally, we explored the predictive power of Clinical practice in coding using
sociodemographic and academic variables (age, years of educa-
tion, years of registration and number of withholdings) in gaming
ICD-10 as a source of inspirations for
behavior. the implementation of ICD-11. A
Methods.– The study comprised 908 university students qualitative analysis
(Mage = 22.07, SD = 7.08), 525 females (57.8%). All participants W. Kosmowski
filled online the Gaming Addiction Scale (Lemmens, Valkenburg, Nicolaus Copernicus University, Department of Psychiatry, Bydgoszcz,
& Peter, 2009; Portuguese version of Baptista, Viegas, & Gradil, Poland
2010). Background and aims.– ICD-10 has been used in Poland since 1996.
Results.– These results are consistent with the literature, highlight- The aim of this study is to compare clinical descriptions, written
ing the increase in gaming behaviors among youths in the last years. diagnoses and ICD-10 codes used by professionals. Even a per-
Besides, it were found positive correlations among pathological fect diagnostic system can be used in proper or improper way.
gaming and some sociodemographic variables. The results may be beneficial for the preparation of doctors and
Conclusions.– The above-mentioned results shed light on the ques- statisticians for the changes forced by ICD-11.
tion “Why do some individuals undergo this transition from Methods.– 500 medical histories, containing referrals to psychiatric
recreational to addictive gambling/gaming behaviors?”, as it allows care or discharge summaries from both psychiatric and non-
to reflect on the influence of some moderating variables. In future psychiatric wards, were randomly selected from the psychiatric
studies, it seems important to explore the impact of the Gaming outpatient clinic records from years 2017–2018. All codes were
Disorder in the quality of life of gamers. assigned by doctors.
Disclosure of interest.– The authors have not supplied a conflict of A competent psychiatrist compared codes with medical data.
interest statement. Results.– The types of errors were as follow. Different names
than the official ICD-10 translation were used to diagnose certain
disorders. General codes were implemented to describe specific
problems (e.g. nicotine dependence coded as Z72 instead of F17.2).
The most important error was incompatibility of the code and Background and aims.– Body dysmorphic disorder (BDD) previously
description (e.g. ADHD coded as G98 instead of F90). known as ‘dysmorphophobia’ is defined as a preoccupation with
Conclusions.– The implementation of the new ICD-11 classification imagined imperfections in physical appearance. Currently, it is rec-
must be preceded by thorough training of doctors and statisticians ognized that patients with BDD do not necessarily perceive their
to avoid the errors described above. Moreover, training in the use symptoms as unreasonable and their ideas may be described as
of ICD-10 is needed to ensure the accuracy of codes in the current overvalued or delusional. It is sometimes difficult to distinguish
documentation. It is crucial to translate codes from ICD-10 to ICD- between BDD and delusional disorder (DD) somatic type especially
11 in a proper way. when BDD is associated with delusional ideas.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– We will discuss a clinical case and we will proceed to a
interest statement. literature research about this case.
Results.– The patient is a 25 years old man hospitalized for suicidal
ideation. The patient was convinced that he had a cranial deformity
E-PP0231 and that everyone was laughing at him because of the distorted
ICD-11 ecological implementation aspect of his skull. These ideas appeared in adolescence. The patient
field studies in russia: focus on was obsessed with this idea; he was afraid to go out of his house and
had repetitive behaviours (mirror checking,growing hair, wearing
psychotic disorders
a cap). The content of his concerns were sometimes so weird that
M. Kulygina1* , V. Krasnov1 , P. Ponizovsky1 , G. Reed2
1 they seemed delirious. The patient did not consider his ideas to be
V. Serbsky National Medical Research Centre on Psychiatry and
unreasonable or absurd. He had also delusional ideas of reference.
Narcology, Moscow Research Institute of psychiatry, Moscow, Russia;
2 WHO, Department of Mental Health and Substance Abuse, Geneva, The main suspected diagnoses were BDD and DD somatic type. The
patient was treated with several antipsychotic drugs (haloperidol,
Switzerland
* Corresponding author. risperidone, olanzapine, amisulpride) without any improvement.
Conclusions.– Distinguishing between BDD with delusional beliefs
Background and aims.– ICD-11 field studies are being conducted and DD somatic type is important because of the therapeutic
through the WHO’s International Field Study Centers in coun- implications. Delusional syndrome in general, may respond to
tries representing all WHO regions. Ecological Implementation field antipsychotics, whereas in BDD, even with psychotic ideas, there is
studies evaluate the clinical consistency and utility of the proposed less likelihood of success.
guidelines in natural practice condition. In the Russian Federation, Disclosure of interest.– The authors have not supplied a conflict of
Moscow Research Institute and P.P. Kaschenko 1st St. Petersburg interest statement.
City Mental Hospital have been assigned as the local sites for these
purposes.
Methods.– 44 psychiatrists participated in the study, which evalu- E-PP0233
ated patients presenting with psychotic symptoms. Clinician raters Visual attention task is associated
conducted interviews together and made independent diagnoses with increased theta/alpha ratio in
that were used to calculate inter-rater reliability. Data were gath- specific brain regions
ered from 104 diagnostic interviews with adult patients. A. Yadollahpour1* , F. Riahi2 , M. Naraghi-Arani1
Results.– The results demonstrate high ratings of clinical utility 1 Ahvaz Jundishapur Univeristy of Medical Scineces - Ahvaz - Iran,
and implementation characteristics of the guidelines. Russian clin- Medical physics, Ahvaz, Iran; 2 Ahvaz Jundishapur Univeristy of
icians participating in the ICD-11 Field studies consider the ICD-11 Medical Scineces - Ahvaz - Iran, Psychiatry, Ahvaz, Iran
Guidelines for Schizophrenia and other primary psychotic disor- * Corresponding author.
ders to be quite easy for use as well as clear and understandable
and with good fit. However the reliability of diagnostic conclusions Background and aims.– Identifying quantified markerof attention
for Schizophrenia and Schizoaffective disorders was found to be task is necessary for developing new modalities for controlled
moderate compared to good or very good in the broader sample. enhancement of attention in healthy and cognitive impairment
Conclusions.– Such tendency may be related to the differences in patients. EEG based measures are valuable biomarkers for attention
how the clinicians conceptualize psychotic disorders according process. This study aims to investigate the potential of theta/alpha
to their diagnostic attitudes based on the Russian clinical psy- ratio as an attention measure and to identify the brain regions
chopathological traditions. Results will be used to identify areas involved in visual attention task processing using attentional net-
of lower diagnostic agreement in psychotic disorders assessment work task (ANT).
as well as to analyze translation issues and country specific differ- Methods.– This was an open label single-blind trial conducted
ences that could be used to make further additional comments to on healthy right handed university students (n = 30; 18–28 years
ICD-11 diagnostic guidelines on the national level. old). The EEGs (19 channel 10–20 system) of the subjects were
Disclosure of interest.– The authors have not supplied a conflict of recorded under two states: eyes open resting state and attentional
interest statement. state when subjects performing the ANT. The theta (4–7 Hz)/alpha
(8–13 Hz) ratio was calculated and the averaged values for the two
states were compared for all 19 electrode sites. The correlation
E-PP0232 between theta/alpha ratios and the alerting, orienting, and exec-
Body dysmorphic disorder or utive control scores of ANT was calculated.
delusional disorder ?: a case report Results.– The theta/alpha ratios under the attentional state signifi-
A. Rebai1 , S. Tlili2 , R. Maamouri3* , R. Triki4 , O. Moula4 , R. cantly increased in C4, P4, T6 (p < 0.05), and Fz compared with the
Ghachem4 resting state (p < 0.001). In contrast, F7, F8, T3, and T4 sites showed
1 Medical School of Tunis, Department of Psychiatry, Tunis, Tunisia; 2 reduced ratios under attentional state, but the reductions were
Medical School of Tunis, Family Medecine Department, Tunis, not statistically significant. Moreover, the theta/alpha ratios during
Tunisia; 3 Medical School of Tunis, Psychiatry, Tunis, Tunisia; 4 resting state showed significant correlations with orienting score
Hospital Razi, Pinel Psychiatry B, Mannouba, Tunisia of ANT in O1, O2, and F8 sites (figure 1).
E-PP0235
Validation of the russian version of
the cyberchondria severity scale
N. Rostovtseva1 , E. Rasskazova2 , A. Tkhostov3 , A. Chepeliuk4* , O.
Tikhomandritskaya5
1 Moscow State University, Clinical psychology, Moscow, Russia; 2
Moscow State University- Mental Health Research Center, Clinical

Psychology- Medical Psychology, Moscow, Russia; 3 Moscow State
University- I.M. Sechenov First Moscow State Medical University,
Clinical Psychology, Moscow, Russia; 4 Moscow State University,
Clinical Psycholgy, Moscow, Russia; 5 Moscow State University, Social
Psychology, Moscow, Russia
Figure 1. The theta/alpha ratios.

Background and aims.– Cyberchondria is defined as an exces-
Conclusions.– The theta/alpha ratio particularly in Fz and middle of sive online search for health-related information, which causes
frontal regions may be an attention task marker. The right hemi- or strengthening of anxiety about health (Starcevic, Berle, 2013).
sphere in right handed individuals is involved in the attention task Although there is the measure to assess this construct, it is a mat-
processing. ter of dispute, is the cyberhondria a part of hypochondria or of
Disclosure of interest.– The authors have not supplied a conflict of problem internet use. The aim was to validate Russian version of
interest statement. the Cyberchondria Severity Scale (CSS) and to compare cyberchon-
dria with both the problem user activity and behavior typical for
hypochondria disorder.
E-PP0234 Methods.– 126 adults (18–70 years old, M = 37.6; SD = 11.8) filled
The seven steps of the The Cyberchondria Severity Scale (McElroy, Shevlin, 2014), Chen
clinical-qualitative content analysis: a Internet Addiction Scale (Chen et al., 2003), Scale for Assessing Ill-
data-processing technique for ness Behavior (Rief et al., 2001), Cognitions About Body and Health
Questionnaire (Rief et al., 1998).
research into clinical care settings
Results.– 5-factor structure explained 61.97% of variance with an
D.B. Faria-Schützer, R. Bastos* , V. Alves, C.J.G. Campos, F.G. Surita,
excellent reliability for the overall measure (Cronbach ␣ = .93) and
E.R. Turato
good to excellent for subscales (.85-.94). All but one subscales of CSS
State University of Campinas, Laboratory of Clinical-Qualitative
correlated to Internet Addiction Scale (r = .37). Cyberchondria was
Research LPCQ, Campinas, Brazil
* Corresponding author. related to autonomic sensations (r = .23), bodily weakness (r = .23),
intolerance of bodily complaints (r = .29) and somatosensory ampli-
Background and aims.– Qualitative research procedures are not fication (r = .29). Illness behavior was related to “Reassurance” scale
always well understood or correctly applied in the Health context, (r = .16-.33).
especially in the data analysis step. Our methodological proposal Conclusions.– Results support reliability and validity of the Russian
considers that one oftupes of qualitative research applied in the version of the CSS. Cyberchondria is related to both excessive inter-
health field can acquire an analogous perspective to clinical prac- net use and illness behavior but relationships are medium. Research
tice. The Clinical-Qualitative Content Analysis aims to explore is supported by the Russian Foundation for Basic Research, project
emotional meanings through individual interviews. No. 18-013-01222.
We aimed to present a systematized and concise technique of Disclosure of interest.– The authors have not supplied a conflict of
step-by-step procedures for certain refined content analysis in the interest statement.
assistance health field: The Clinical-Qualitative Content Analysis.
Methods.– Methodologically, the qualitative research design, when
applied to the field of health, can have a way analogous to the
E-Poster Presentation: Comorbidity - Dual
traditional approach in professional clinical practice, thus the
denomination: clinical-qualitative content analysis. This kind of Pathologies - Part I
analisys is a section of the Clinical-Qualitative Method, such as it
was developed in the Brazilian environment academic.
Results.– The Clinical-Qualitative Content Analysis technique com- E-PP0236
prises seven steps: 1) Editing material for analysis; 2) Floating When a neurological condition is
reading; 3) Construction of the units of analysis; 4) Construction interpreted as psychiatric disorder
of codes of meaning; 5) General refining of the codes and the Con- P. Argitis1* , K. Charisiou2 , A. Kourti1 , C.M. Platsa1 , D. Garnelis1 , A.
struction of categories; 6) Discussion; 7) Reflexivity. Karampas3 , K. Paschalidis4 , I. Merianos1 , Z. Chaviaras1
Conclusions.– As final considerations, we state it is a proposal for 1 General Hospital of Corfu, Psychiatric, Corfu, Greece; 2 University
systematization qualitative content analysis procedures in order Hospital Ofioannina, Neurology, Corfu, Greece; 3 University Hospital
to bring clarity to the researcher who intends to do qualitative of Ioannina, Psychiatric, Ioannina, Greece; 4 Psychiatric Hospital of
research in clinical settings and ensure quality of the analysis. It Thessaloniki, Psychiatric, Ioannina, Greece
is a technique indicated for questions arising in an assistance set- * Corresponding author.
ting and that seek to encourage reflections an interventions for
professionals faced with the life experiences of their patients. Background and aims.– It is common knowledge that many neu-
Disclosure of interest.– The authors have not supplied a conflict of rological conditions manifest with psychiatric symptoms, such as
interest statement. cognitive impairment, mood disorders, personality changes or even
psychotic symptoms, either on the early or on the late stages. Some
of those diseases are of infectious or autoimmune cause, others are
related to seizures, stroke or trauma. Additionally, the neuropsychi-
atric symptoms may be due to hormonal or metabolic disorders,
CNS tumours or Paraneoplastic syndromes of non-CNS tumours. E-PP0238

One of the maincases of psychiatric conditions’ occurrence in the Comparative retrospective study of
context of brain disease and one that is very often mentioned in
schizophrenic patients with/without
international literature, is reversible or irreversible dementia of
various origin.
substance use disorder and
Methods.– We present a case series in which the patient was employment in Bulgaria
admitted to our unit due to psychiatric symptoms. After thorough P. Chumpalova1* , V. Valtchev2 , L. Tumbev1 , M.
examination as well as imaging and other tests needed for the dif- Stoimenova-Popova1 , I. Veleva1 , K. Stoychev1
1 Medical University, Psychiatry and Medical Psychology, Pleven,
ferential diagnosis, we reached a completely different conclusion.
Results.– Dementias are in many cases misdiagnosed as psychiatric Bulgaria; 2 National Sports Academy, Physiology and Biochemistry,
disease due to an overlap of the symptoms present in such con- Sofia, Bulgaria
ditions. With the eligible treatment for dementia in some of them
remission was achieved, while in others of irreversible cause no
Background and aims.– Comorbidity substance use disorder
specific change was observed and palliative care with symptomatic
increases the financial cost of schizophrenic patients, complicates
medication was offered.
contacts with relatives, people in the social environment, and
Conclusions.– Whatever the reason might be for the psychopathol-
controlling medical structures and, as a result, exacerbates social
ogy present in neurological conditions in general and dementias
isolation
in particular, the result is often misdiagnosis of the latest as psy-
Methods.– After screening and on the basis of “inclusive” and “exclu-
chiatric ones. Thus, dementia should be excluded from differential
sive” criteria in accordance with the study design were established
diagnosis before characterizing a condition a psychiatric one.
two distinct groups with a total of n = 202: 101 hospitalized patients
with schizophrenia and comorbid substance abuse and hospitalized
interest statement.
patients with schizophrenia without substance use in a compara-
ble ratio by sex, age, place of residence and level of education with
E-PP0237 the study group with comorbidity.
Results.– The results of our study detected a significant propor-
Incidental discovery of somatic tion of patients with schizophrenia and comorbid substance use
pathology in psychiatric patients disorder (75.3%) have a workload before the onset of mental disor-
I. Baati* , S. Snoussi, K. Yaich, S. Ellouze, R. Sellami, M. Moalla, I. der. In the course of the disease, the ratio of work capacity in the
Feki, J. Masmoudi two groups under study changed - a significantly higher proportion
Hedi Chaker University Hospital- Sfax- Tunisia, Department of of men and women without substance use disorder continued to
Psychiatry “A”, Sfax, Tunisia work compared to both man and female with schizophrenia and
comorbid substance use disorder. The non-working women with
comorbid schizophrenia are significantly higher (54.2%) compared
Background and aims.– Somatic comorbidities in patients suffering
to the non-working men with comorbid schizophrenia (37.7%).
from psychiatric disorders represent a substantial burden, and have
Most patients with schizophrenia and comorbid substance use dis-
become an important issue in the overall care of these patients.
order (60%) are unemployed and patients with schizaphrenia and
Objective.– To study the prevalence of somatic pathology first-
comorbid alcohol use are the most in the group of the disabled by
discovered (SPFD) in psychiatric patients.
mental disorder (87%).
Methods.– This was a retrospective and descriptive survey, con-
Conclusions.– Coordinated efforts at the national, state, and pro-
ducted during the period from January 2015 to December 2017 at
gram levels will be required to remove barriers and to provide
the Psychiatry“A” department, in Hedi Chaker University Hospital
optimal care for this vulnerable population.
in Sfax (Tunisia).
We included all patients presenting at least a SPFD during their
interest statement.
hospitalization and we excluded those with physical or biological
disorders secondary to psychotropic drugs.
Results.– Among 209 patients hospitalized, we identified 73 E-PP0239
patients (34,9%) with at least one SPFD. The total number of SPFD
was 119. The mean age of our patients when diagnosed with Comparing comorbidity of chronic
SPFD was 43.56 years (SD = 15.05). The most common psychi- pain and depression between Asian
atric disorders affecting our patients were bipolar disorder (38.3%), Americans and European Americans
schizophrenia (19.2%) and schizoaffective disorder (12.3%). The M. Park
prevalence of SPFD was 56.9% by number of patients and 50.2% by University of California San Francisco, Dept. of Family Health Care
number of hospitalizations. These SPFDs were mainly hematologi- Nursing, San Francisco, USA
cal disorders (42.5%, 31/73), endocrine diseases (24.7%, 18/73) and * Corresponding author.
heart diseases (15.1%, 11/73). SPFDs were acute in 70.6% of cases

and chronic in 29.4% of cases. Background and aims.– Literature have suggested that minority
Conclusions.– Searching somatic comorbidities is crucial, con- patients may experience greater rates of pain and psychiatric
sidering its high prevalence and important implications on the comorbidities than their White counterparts in the U.S. However,
management of psychiatric patients. few studies have confirmed such a hypothesis, using a large repre-
Disclosure of interest.– The authors have not supplied a conflict of sentative data. To fill this knowledge gap, we examined if Asian
interest statement. Americans experience chronic or disabling pain at rates similar
to European Americans and if gender and ethnicity modify the
associations between chronic or disabling pain and psychiatric
morbidities.
Methods.– Using a representative sample of community-residing
U.S. adults (2284 Asian Americans and 6696 European Americans),
lifetime and 12-month pain were assessed by self-report. We used
weighted descriptive statistics and multivariate logistic regression.
Covariates included sociodemographic and immigration character- E-PP0241

istics. Gender identity disorder symptoms in
Results.– Approximate 35.8% of Asian Americans (95% CI: 32.9–38.8)
young Russian women with comorbid
and 56.8% (95% CI: 54–59.5) of European Americans endorsed
lifetime chronic pain. About 30% (95% CI: 27.6–32.2) of Asian Amer-
endogenic mental disorders
icans endorsed 12-month chronic pain and 21.1% (95% CI: 19.5- T. Piskareva* , S. Enikolopov
22.8) endorsed disabling pain in the past 12 months. Pain was sig- Mental Health Research Center, Medical Psychology, Moscow, Russia
nificantly associated with increased odds for having psychiatric
morbidity during the corresponding time period in both Asian Background and aims.–
Americans and European Americans (ranged between 2.04 and Introduction.– Gender identity disorder can be diagnosed when
10.31 folds). There were significant gender and ethnic variations a person expresses “a strong and persistent cross-gender
in the prevalence of co-morbid pain and depression. identification. . ., which must not be a symptom of another men-
Conclusions.– Compared to European Americans, Asian Americans tal disorder”(ICD-10). Therefore some patients with schizophrenia,
report lower rates of lifetime pain morbidity but a similar strength personality disorders and endogenic affective disorders report of
of association between pain and psychiatric morbidity. the persistent desire to change their biological sex, which remains
Disclosure of interest.– The authors have not supplied a conflict of even during remission periods. These cases have not been investi-
interest statement. gated, since they are usually excluded from demographic and other
studies.
Objectives.– This study seeks to address how gender identity disor-
E-PP0240
der (GID) symptoms are represented in young women with mental
Lifetime suicide attempts are disorders.
associated with mood disorders and Methods.– The sample consisted of twenty-five women with diag-
tobacco use disorder nosed mental disorders and GID symptoms, aged 16–26, and
L. Piccoli-Melo* , S.O.V. Nunes, H.O. Vargas twenty-three women of the same age and nosological groups with-
Londrina State University, Department of Clinical Medicine- out GID symptoms. The structure of gender identity was measured
Psychiatry Unit, Londrina, Brazil by Bem Sex-Role Inventory, Projective Tests.
* Corresponding author. Results.– Patients with GID symptoms had significantly more severe
psychiatric symptoms, then those without GID. They were divided
Background and aims.– Mood disorders have been associated with into three groups according to gender identity impairment type:
elevated levels of high sensibility C-reactive protein (hs-CRP) and tangled (positive attitude towards both M and F roles, but nega-
components of the lipid profile, which could be a risk factor for sui- tive attitude towards themselves; mostly found among affective
cide attempts. The co-occurrence of mood disorders with Tobacco disorders), underformed (thought about themselves as children
Use Disorder (TUD) has also been associated with the increase of or adolescents in attempt to evade the sex conflict; comorbid
suicide risk. To investigate if TUD and lipid profile levels may influ- with personality disorders), rejected (had negative or ambiva-
ence mood disorders in subjects with lifetime suicide attempts. lent attitude towards F role, and positive or neutral towards M
Methods.– Psychiatric outpatients with (n = 79) and without role; significantly related to schizophrenia). All patients with GID
(n = 460) a history of lifetime suicide attempts were submitted to a symptoms were androgenic according to Bem Sex-Role inventory,
questionnaire, a structured clinical interview for TUD, Bipolar Dis- whereas 74% of patients without GID symptoms were feminine.
order (BD) and Major Depressive Disorder (MDD). They were also Conclusions.– This study shows the importance of accurate investi-
evaluated by Hamilton Depression Rating Scale (HDRS17 ), Fager- gation of GID cases in mental disorders.
ström Test for Nicotine Dependence (FTND), Body Mass Index Disclosure of interest.– The authors have not supplied a conflict of
(BMI), and lipid profile and hs-CRP levels. interest statement.
Results.– Lifetime suicide attempts were mostly women (p = 0.002),
more diagnoses of obesity (p = 0.001), BD (p = 0.000) and
TUD (p = 0.001), more severity on FTND (p = 0.027) and on E-PP0242
HDRS17(p = 0.000), high number of smoking cessation attempts Does methadone promote
(p = 0.021), high levels of hs-CRP (p = 0.005), and inflamma-
antipsychotic adherence among
tory state and high cardiovascular risk (hs-CRP > 3 mg/L,
p = 0.030). A multivariate analysis showed that lifetime suicide dually-diagnosed patients exposed to
attempt group suffer significant influences of TUD (Odds Ratio, correctional supervision?
OR = 2.005, 95% Confidence Interval, CI = 1.087–3.696; p = 0.026), S. Rezansoff BCom- MS- PhD- PDF
BD (OR = 23.31, CI = 8.723–62.291; p = 0.000) and MDD (OR = 9.650, Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada
CI = 3.441–27.065; p = 0.000) after controls by gender and age.
Conclusions.– These results evidenced that lifetime suicide
attempters have more BD mostly, followed by MDD and TUD diag-
Introduction.– Substance use disorders are common among peo-
noses independently. Therefore, it suggests that mood disorders
ple with schizophrenia and undermine antipsychotic adherence;
(BD mostly) and the TUD diagnoses can impact in the lifetime sui-
a clinical profile prevalent in justice-involved populations. Opi-
cide attempt prevention.
oid agonist treatment increases adherence to pharmacotherapy
of comorbid infectious disease (e.g., HIV). Little clinical research
interest statement.
investigates the concurrent treatment of opioid dependence and
schizophrenia, despite the current North American opioid crisis and
the fact that opioid overdose is the leading cause of death on release
from custody internationally.
Objectives.– Does methadone potentiate antipsychotic adherence
among dually-diagnosed patients exposed to correctional supervi-
sion?
Methods.– Over a 17-year period, using linked administrative data,
we estimated the temporal association between methadone and
antipsychotic adherence in a large (N = 1,996), retrospective cohort E-PP0244

of justice-involved adults diagnosed with concurrent opioid depen- Ipmact of obssessive-compulsive
dence and schizophrenia. We applied a panel data design using
disorder in patients with bipolar
120-day cycles, controlling for relevant variables. Adherence was
estimated using the medication possession ratio (>0.80), calculated
disorder
in each 120-day period beginning with the first date of concurrent N. Sahar* , J. Ben Thabet, W. Bouattour, M. Maalej Bouali, S. Omri, R.
use of methadone and antipsychotic medication. Feki, N. zouari, L. Zouari, N. Charfi, M. Maalej
Results.– Eligible participants were predominantly white (74%) CHU Hedi Chaker, Psychiatry C, Sfax, Tunisia
males (68%) of approximately 35 years of age and followed for
an average of 6.4 years. Methadone adherence (>.80) more than Background and aims.– Comorbid obsessive-compulsive disorder
doubled the odds (AOR: 2.07; CI: 1.09–1.25) of subsequent antipsy- (OCD) is common among bipolar patients. We aimed to assess the
chotic adherence. Despite this strong temporal association, overall comorbidity rate of obsessive compulsive disorder and obsessive
adherence levels for both medications were below 50% throughout compulsive symptoms (OCS) in patients with bipolar disorder and
the study period. the eventual association with functionality
Conclusions.– Antipsychotic adherence was significantly associated Methods.– 30 out-patients with Bipolar Disorder (BD) were
to subsequent methadone adherence, although adherence to both recruited for this study f rom September to October 2018. Only
medications was low. Opioid agonist treatment and antipsychotics remitted BD patients were included using Hamilton Depres-
should be prescribed concertedly, particularly during transitions sion Rating Scale (HDRS) and Young Mania Rating Scale (YMRS).
between custody and community supervision. Yale-Brown Obsessive-Compulsive Scale, Yale Brown Obsessive
Disclosure of interest.– The authors have not supplied a conflict of Compulsive Symptom Screening Inventory and Global Assessment
interest statement. of Functioning Scale (GAF) were applied to patients
Results.– The mean age of our patients was 40.47 years (min = 23,
max = 64). They were females in 83.3% of cases (sex ratio = 0.2). They
E-PP0243
were married in 57.5% of cases. The age of onset of bipolar disor-
VHC among drug-dependent der was 27.07 years (min = 43, max = 17) years. The first episode
inpatients: the relevance of dual was a depression in 53.3% of cases. The mean number of suicide
disorders attempts was 0.37 (min = 0, max = 4). Among our patients 26.6%
C. Roncero1,2,3* , C. LLanes4 , J. de la Iglesia1 , N. Casado1 , M.Á. had obsessive-compulsive disorder or symptoms (N = 8). Aggres-
Garzón5 , L. García-Ullán1,2,3 , M.L. Aguilar1,2,3 , E. Álvarez-Lamas5 , sive then religious obsessions were seen most frequently (44.4%
M.P. Andrés1 , B. Vicente5 , M.P. Ciudad5 , A. Alvarez5 and 22.2% respectively). Verification compulsions were the most
1 University of Salamanca Health Care Complex, Psychiatry, common (57.1%). Patients without OCS or OCD had a better Global
Salamanca, Spain; 2 University of Salamanca, Psychiatry, Salamanca, Assessment of Functionality score (p = 0.003). Number of hospi-
Spain; 3 University of Salamanca, Institute of Biomedicine of talizations and suicide attempts in psychiatric history were not
Salamanca, Salamanca, Spain; 4 Zamora Health Care Complex, significantly higher for patients with obsessive compulsive symp-
Psychiatry, Zamora, Spain; 5 University of Salamanca Health Care toms (p = 1.000).
Complex, Dual Diagnosis Unit. Psychiatry Service., Salamanca, Spain Conclusions.– Our findings indicate that obsessive-compulsive
* Corresponding author. symptoms are seen frequently among patients with bipolar dis-
order, and could have an effect upon the course of bipolar disorder
Background and aims.– Drug use has been associated to high especially global functionality.
prevalence of VHC+, although there are few studies made in Disclosure of interest.– The authors have not supplied a conflict of
Detoxification/Dual Disorders units. There is scarce information interest statement.
on the influence of other mental disorders among drug-dependent
patients, so called Dual Disorder/Dual Diagnosis (DD) in the preva-
lence of HCV. E-PP0245
Methods.– Descriptive, observational, retrospective study of 830 Disorders of emotions and
drug-dependent patients hospitalized between 2014–2017. Of motivations in children after severe
them, 279 were HCV+ and 4% were People Who Inject Drugs (PWID).
We compared the clinically relevant characteristics of a DD-group
spinal trauma
versus a non-DD group all of them HCV+. Y. Sidneva
Results.– Among the HCV+ patients, 69% had DD: 45% personal- Clinical and Research Institute of Emergency Pediatric Surgery and
ity disorders, 35% affective disorders, 13% anxiety disorders and Trauma- N.N. Burdenko National Medical Research Center of
10% psychotic disorders. In the DD patient group 23% were women Neurosurgery, Neurorehabilitation and Recovery Treatment-
compared to 14% in the non-DD group. 28% of the patients in the Neurosurgery, Moscow, Russia
DD group were HIV+, versus 34% in the non-DD group. Cocaine Background and aims.– Psychological and psychiatric disorders of
was consumed by 33% of the DD patients and 40% of the non-DD varying severity are revealed after a spinal trauma (ST). Emotions
patients. The number of PWID at the time of admission was not after SCI are studied in adults; data on the study of emotional dis-
significant in any of both groups, but 70% of those who inject had orders in children, and their medical treatment is not.
a DD.A treatment for HCV had been made by 7% of DD patients Aims.– To evaluate emotions and motivations in children after
compared to a 28% among the non-DD group severe ST in early rehabilitation.
Conclusions.– HCV infection is higher in DD patients. HCV+ patients Methods.– 35 children with severe ST (8–18 years old) admitted to
with DD had received treatment with interferon or with direct- treatment and rehabilitation. Psychological and psychopathologi-
acting antivirals (DAAs) with significantly less frequency than cal methods were used. Diagnostic scales and questionnaires used
non-DD patients. Therefore, patients with HCV+ and DD are a risk to detect depression, to assess the severity of individual symptoms.
group and an important reservoir of HCV+,which must be taken Results.– three groups of children were identified, depending on
into account in order to be referred for treatment of HCV emotional disorders and their severity: 1 - with depression 6 (2
Disclosure of interest.– The authors have not supplied a conflict of boys, 4 girls from 14–17 years old), 17.2%; 2 - with high anxiety,
interest statement. decreased motivation, with subdepressive prerequisites 11 (4 girls,
7 boys from 12–16 years old), 31.4%; 3 - no depression or depressive
tendencies 18 (15 boys, 3 girls, 8–17 years old), 51.4%. Children with
a lowering of emotions, with an average or low level of anxiety, but a other psychiatric disorder. Comorbidity is associated by severity of
safe motivation, needed only the accompaniment of a psychologist. clinical presentation, poor prognosis, and outcome.
Children with a decrease in emotions, medium or high levels of The aim of the study was to determine the frequency and to exam-
anxiety and low motivation needed the treatment of a psychiatrist ine the most common somatic disorders in patients with bipolar
and a psychologist. Children with depression, high anxiety and low disorder at the Psychiatric Hospital of Sarajevo Canton during the
motivation required the supervision and medical treatment of a period of one year.
psychiatrist. Methods.– The study included 27 out of 574 patients hospitalized for
Conclusions.– In 48.6% of children after severe spinal trauma there a stated period. The patients were diagnosed with bipolar disorder
are emotional and motivational disorders requiring differentiated according to ICD-10 criteria. Patients’ age and sex were were taken
psychological and psychiatric care in the period of early rehabil- in consideration, as well as the presence of somatic disease.
itation with the algorithm of joint interaction in the treatment Results.– Sixteen patients with bipolar disorder (59.25%) were
complex. females and 11 (40.74%) were males. All patients that were included
Disclosure of interest.– The authors have not supplied a conflict of in this study met the criteria for one or more comorbid diagnoses,
interest statement. of which 28.5% met criteria for one, and 71.5% for two comorbid
disease. Twelve patients (44.44%) had cardiovascular disease, ten
(37%) had hypertension, and two patients (7.4%) had post-stroke
E-PP0246 condition. In nine (33.3%) patients dyslipidemia was found, four
The alpim (anxiety, laxity, pain, (14.81%) patients had diabetes mellitus type 2, and two (4.7%)
immune and mood) syndrome in patients were diagnosed with thyroid disease.
Conclusions.– Comorbidity is a product, rather than a sum of two
adolescents and young adults- a
or more diseases, which makes this problem more demanding for
cohort study treatment. An interdisciplinary approach is needed in treatment
D. Singh of these patients with emphasis on individual approaches, basic
NYU Winthrop Hospital, Behavioral Health, Mineola, USA follow ups and introduction to a new lifestyle.
Background and aims.– The ALPIM (Anxiety, Laxity, Pain, Immune, Disclosure of interest.– The authors have not supplied a conflict of
and Mood) Syndrome has been described in adults as a spectrum interest statement.
disorder which incorporates distinct med-psych comorbidities. We
explore its occurrence in adolescents and re-assess its existence
in adults. Additionally, separation Anxiety Disorder (SAD) was E-PP0248
explored as a comorbidity.
Aid to patients with alzheimer’s
Methods.– Medical records of patients aged 11 to 34 with a diagnosis
of depression, or anxiety (panic disorder, SAD, social anxiety or gen- disease that is complicated by
eralized anxiety disorder (GAD)) seen during a 1-year period were psychotic disorders
reviewed. Data were collected on the presence of ALPIM comorbidi- I. Strelnikova* , V. Koshchii
ties. Analyses were conducted to detect their co-occurrence and Kharkiv National Medical University, Psychiatry- Narcology and
evaluate possible predictors of the ALPIM syndrome. Medical Psychology, Kharkiv, Ukraine
Results.– Inclusion criteria were met by 185 patient-charts. A signif-
icant association was noted between the ALPIM comorbidities with
20 subjects (10.8%), meeting criteria for ALPIM syndrome (patients
Introduction.– Extending the life expectancy and aging of popula-
with one or more diagnoses from each ALPIM domain). Patients
tion on the globe leads to an increase of cases of dementia. The most
with SAD had increased odds of being diagnosed with ALPIM
common form of dementia is Alzheimer’s disease. Patients with
(OR = 7.14, 95% CI: 2.48–20.54, p-value < 0.001). Neither MDD nor
dementia require long-term care and treatment, which requires
GAD was found to be predictive of ALPIM syndrome. There was
significant economic and social costs. Impairment of memory,
no difference in the prevalence of ALPIM related comorbidities
speech, visual-spatial orientation, executive and motor distur-
between subjects younger than 18 years vs. 18 years of age or older.
bances. At all stages of the development of Alzheimer’s disease
Conclusions.– Our findings replicate the association of distinct psy-
there may be psychotic disorders.
chiatric and non-psychiatric conditions described as the ALPIM
Objectives.– Treatment of psychotic disorders due to Alzheimer’s
syndrome. Further, the syndrome may present during adolescence.
disease using Aripiprazole.
SAD may be an independent predictive factor for the occurrence
Methods.– A comprehensive clinical and psychopathological exam-
of ALPIM syndrome. Patients with individual ALPIM comorbidi-
ination of 79 patients aged 65 to 82 years old, of both sexes (35 men
ties should be assessed for the syndrome, especially if they have
and 44 women) for Alzheimer’s disease with psychotic disorders.
a history of SAD.
The diagnostic and research criteria of ICD-10, MMSE scale, MoCA,
DAS, PANSS. Patients received therapy with Aripiprazole at a dose
interest statement.
of 15–20 mg per day dividing it into two doses.
Results.– In patients, there was reduction of psychotic symptoms,
E-PP0247 leveling of affective stress, improvement of cognitive parame-
ters (self-orientation, orientation in time and place, improvement
Challenges in psychiatry - chronic of memory and concentration of attention), which affected the
somatic illnesses and psychiatric improvement of visual-spatial orientation, executive acts and
disorders motor activity; an increase of indicators by an average of 0.5 points
R. Softic* , S. Sarkic-Bedak, B. Kurtovic by MMSE scale; improvement of values by all scales of cognitive
Psychiatric Hospital of Sarajevo, Department of Psychiatry, Sarajevo, assessment; increasing the degree of adaptation (cognitive abil-
Bosnia - Herzegovina ity, development of social and domestic skills, the use of adaptive
coping strategies) and positive dynamics of the level of social func-
tioning of the patients.
Background and aims.– Numerous studies have shown great correla- Conclusions.– The obtained results allowed substantiating the expe-
tion between psychiatric disorders and somatic co morbid diseases. diency of therapy of psychotic symptoms in Alzheimer’s disease
There is higher rate of comorbidity in bipolar disorder than in any using Aripiprazole.
Disclosure of interest.– The authors have not supplied a conflict of and mixed subtype (MX- relating to manual dexterity, coordina-
interest statement. tion between upper and lower limbs, dysdiadochokinesia, imitation
of gestures, digital praxis, digital perception disorders, and items
failureassociated to VSC-DCD).
E-PP0249 Methods.– Eighteen children (4–15 years old) with ASD were com-
Prevalence and clinical correlates of pared to 58 children with DCD (33 VSC-DCD, 25 MX-DCD). All
self-injurious behavior in gilles de la children were assessed with neuropsychological tests and with a
French standardized neurodevelopmental battery “the NP-MOT”.
tourette syndrome
Results.– Failures of all the markers of DCD were most weakly
N. Szejko1* , A. Jakubczyk2 , P. Janik3
1 impaired or sometime better in our sample of ASD children versus
Medical University of Warsaw, Department of Neurology and
DCD group. Thus, impairments of ASD were not specific to the diag-
Bioethics, Warsaw, Poland; 2 Medical University of Warsaw,
nostic markers of DCD because no correlation was found between
Department of Psychiatry, Warsaw, Poland; 3 Medical University of
predictive markers described for each DCD subtype, making its
Warsaw, Department of Neurology, Warsaw, Poland
* Corresponding author. impairments unlikely associated to a DCD diagnosis as a comor-
bidity of ASD.
Background and aims.– Gilles de la Tourette syndrome (GTS) is a Conclusions.– These results support the hypothesis about sensorial,
neurodevelopmental disorder affecting children and adults. Major motor and psychomotor impairments in the ASD children belong-
symptoms are tics, but in 90% of cases psychiatric comorbidities ing to a global aetiology of sensory-motor integration disturbance
occur. Self-injurious behavior (SIB) is defined as deliberate and which include various cortical brain regions, the corpus callosum,
repetitive infliction of self-harm and could be found in 4–53% subcortical networks (basal ganglia) and the cerebellum.
patients with GTS. The aim of our study was to investigate lifetime Disclosure of interest.– The authors have not supplied a conflict of
prevalence and risk factors of SIB in Polish cohort of GTS patients. interest statement.
Methods.– Diagnosis of GTS and psychiatric disorders was estab-
lished according to DSM-IV-TR criteria. We evaluated SIB severity
and divided patients, into mild, moderate and severe SIB groups E-PP0251
according to strict definition which will be provided on poster. Evaluation of alcohol and other drug
Results.– SIB was reported by 65 patients (39.4%). The age of SIB dependency in hypertension and
onset was known in 55 cases (84.6%) and the average value was of diabetes with primary care
11.4 ± 6.8 years. In 30 patients (46.2%) SIB was evaluated as mild, M.C. Vastag Ribeiro De Oliveira* , G.M. Evangelista, R. Santos
in 27 (41.5%) as moderate and in only 9 (13.9%) cases as severe. Our University of Western São Paulo, Faculty of Nursing, Presidente
results of univariable analysis showed, that SIB in GTS was asso- Prudente, Brazil
ciated with: ADHD, OCD, aggression, depression, anxiety disorder, * Corresponding author.
significant social skills problems and increased tic intensity as well
as total number of complex tics. Nevertheless, in logistic regression Background and aims.– Chronic diseases are considered a public
only OCD and ADHD remained in significant association with SIB. health problem, since they are responsible for the high mortality
Conclusions.– SIB in GTS could be the consequence of two most rate, as well as for hospitalizations and early economic inactivity.
common co-morbid mental disorders such as OCD and ADHD. Among the main chronic diseases are Hypertension and Diabetes
Disclosure of interest.– The authors have not supplied a conflict of Mellitus, treatment involves habits and attitudes that promote the
interest statement. quality of life so that complications are prevented. Aims to identify
the use of alcohol and other drugs in patients with chronic diseases.
Methods.– Application of specific scales called AUDIT - Alcohol Use
E-PP0250 Disorder Identification Test and ASSIST - Alcohol, Smoking and Sub-
Exploring the specific markers of stance Involvement Screening Test, in the sample of 80 volunteers
developmental coordination disorder with diabetes and hypertension.
Results.– The majority of interviewees were 57.5% (46), among
(DCD) in autism spectrum disorder
those 28.75% (23) had hipertension, 7.5% (6) had Diabetics and
(ASD): DCD is not a comorbidity in ASD 21.25% (17) had both. In relation to the male sex, 42.5% (34) partici-
children pated in the study, with 27.5% (22) hypertensive, 2.5% (2) diabetics
L. Vaivre-Douret1,2,3,4* , A. Paquet5 only and 12.5% (10) hypertension and Diabetes. According to data
1 University of Paris Descartes- INSERM Unit 1178/1018-CESP- collected, the majority of respondents 87.5% in relation to Alcohol,
University of Paris-Sud- UVSQ- Universities of Paris-Saclay and Paris tobacco and other Drugs, make use and consumption of low risk,
Descartes, Faculty of Medicine, Paris, France; 2 Necker-Enfants the diagnoses are performed in the vast majority.
Malades University Hospital- AP–HP, Department of Child Psychiatry, Conclusions.– The female sex being a group that consequently
Paris, France; 3 University Institute of France, Research team attend more health services for the prevention and promotion of
“Neurodevelopment and disabilities”, Paris, France; 4 Imagine health, either for its cultural positioning as caretaker, accountability
Institute- Necker-Enfants Malades University Hospital- AP–HP, with the care of other people. This function is intrinsically related to
Endocrinology Laboratory, Paris, France; 5 Esquirol Hospital, the greater frequency with which women seek the health services,
Research Unit and Neurostimulation, Limoges, France when compared to the men, whose masculinity profile contradicts
the involvement with the care.
Background and aims.– Several studies suggest a comorbidity
interest statement.
of developmental coordination disorder (DCD) in children with
autism spectrum disorder (ASD).
We aimed to study the nature of DCD in ASD compared to a group of
DCD children. We analyzed the salient diagnostic markers of DCD in
accordance to a cluster analysis study which highlighted DCD sub-
types. Profiles of ASD children were compared to two principal DCD
subtypes: visuospatial constructional (VSC- relating to visual motor
integration, visual spatial structuring, Lego blocks impairments)
E-PP0252 Background and aims.– Anxiety and depressive disorders (ADD)

Implementation of a clinical decision affect rheumatoid arthritis (RA) disease activity and treatment
support system for optimizing the response. Psychopharmacotherapy (PPT) of ADD attempts to
improve the treatment response.
dosing mode of Aims.– To determine predictors of RA treatment response.
psychopharmacotherapy in patients Methods.– 128 RA-patients were enrolled, 86% were women
with affective disorders based on with a mean age of 47,4 ± 11,3 yrs. All patients met 2010
pharmacogenic biomarkers ACR/EULARcriteria for RA. The SDAI treatment response cri-
M. Zastrozhin1 , V. Skryabin2 , A. Sorokin2 , V. Matskevich2 , E. teria were used. Mean RA activity was high at baseline
Bryun2 , D. Sychev1 (SDAI 33,5 ± 15,5). ADD were diagnosed in 123 (96,1%) of
1 Russian Medical Academy of Continuous Professional Education of patients in accordance with ICD-10 in semi-structured inter-
the Ministry of Health of the Russian Federation, Addictology, view. Severity of depression and anxiety was evaluated with
Moscow, Russia; 2 Moscow Research and Practical Centre on MADRS and HAM-A, pain–with Brief Pain Inventory (BPI). RA-
Addictions, Addictology, Moscow, Russia patients with ADD were divided into the following treatment
* Corresponding author. groups: 1–conventional disease-modifying antirheumatic drugs
(DMARDs) (n = 39), 2–DMARDs + PPT (sertraline and/or mianser-
Background and aims.– Although pharmacogenetic tests provide the ine) (n = 43), 3–DMARDs + biologic DMARDs (bDMARDS) (n = 32),
information on a genotype and the predicted phenotype, these tests 4–DMARDs + bDMARDs + PPT (sertraline and/or mianserine) (n = 9).
themselves do not provide the interpretation of data for a physi- Logistic regression analysis was conducted to determine predictors
cian. The aim of our study was to study the effect of implementing of treatment response.
the decision support system to optimize the drug dosage regimen, Results.– At 5-yrs endpoint in 83 RA-patients SDAI response rate
based on pharmacogenomic biomarkers, on the efficacy and safety was 73,5% (38,6% and 34,9% for major and minor improvement,
of therapy for patients with affective disorders and comorbid alco- respectively). Non-response rate was higher in DMARDs group
hol addiction. (58%) vs groups 2 (10,4%), 3 (23,8%) and 4 (0%), p < 0,05. According
Methods.– The study included 118 male patients (48 in the main to regression model, SDAI treatment response was associated with
group and 70 in the control group) with affective disorders and successful treatment of ADD (OR = 7,07; 95%CI: 1,04–48,24), base-
comorbid alcohol use disorder. To evaluate the efficacy and safety of line BPImax (OR = 1,42; 95%CI: 1,0–2,02), baseline SDAI (OR = 1,08;
therapy several international psychometric scales and rating scales 95%CI: 1,0–1,18) and younger age (OR = 0,93; 95%CI = 0,87–0,99).
to measure side effects were used. Genotyping was performed Conclusions.– Successful psychopharmacotherapy of ADD and
using real-time polymerase chain reaction with allele-specific younger age independently predict RA treatment response.
hybridization. Pharmacogenetic test results were interpreted using Disclosure of interest.– The authors have not supplied a conflict of
free software PGX2 (www.pgx2.com). interest statement.
Results.– The statistically significant differences between the scores
derived from all psychometric scales were revealed. For instance,
the total score on Hamilton Rating Scale by day 16 was 14.0 [13.0; E-PP0254
15.0] for the main group and 14.0 [13.0; 14.0] (p < 0.001) for the Psychosocial functioning in the
control group. The total score on UKU scale by day 16 was 3.0 [0.0; balance between autism and
4.2] for the main group and 9.0 [7.0; 11.0] (p < 0.001) for the control
group.
psychosis tendencies: evidence from
Conclusions.– Pharmacogenetic-guided personalization of the drug three populations across the
dose in patients with affective disorders and comorbid alcohol use autism-psychosis spectra
disorder can reduce the risk of undesirable side effects and pharma- A. Abu-Akel1* , S.J. Wood2 , R. Upthegrove3 , K. Chisholm4 , A. Lin5 ,
coresistance. It allows recommending the use of pharmacogenomic P.C. Hansen4 , S.M. Gillespie6 , I.A. Apperly4 , C. Montag7
1 University of Lausanne, Institute of Psycholoy, Lausanne,
clinical decision support systems for optimizing drug dosage.
Disclosure of interest.– The authors have not supplied a conflict of Switzerland; 2 Orygen, The National Centre of Excellence in Youth
interest statement. Mental Health, Glenroy, Australia; 3 University of Birmingham,
Institute of Clinical Sciences, Birmingham, United Kingdom; 4
University of Birmingham, School of Psychology, Birmingham, United
Kingdom; 5 The University of Western Australia, Telethon Kids
E-Poster Presentation: Comorbidity - Dual Institute, Subiaco, Australia; 6 University of Liverpool, Psychological
Pathologies - Part II/Consultation Liaison Sciences, Liverpool, United Kingdom; 7 Charité University Medicine
Psychiatry and Psychosomatics - Part III Berlin, Department of Psychiatry and Psychotherapy, Berlin, Germany
Background and aims.– Difficulties with psychosocial functioning is

E-PP0253 central to both autism and psychosis spectrum disorders. While the
Successful psychopharmacotherapy of disorders are diagnostically independent, they can co-occur in the
anxiety and depressive disorders same individual at both the diagnostic and trait levels. The effect
improves rheumatoid arthritis of such co-occurrence is hypothesized to worsen functioning. The
‘imprinted brain theory’, however, suggests that the disorders are
treatment response etiologically and phenotypically diametrical, predicting opposing
A. Abramkin1* , T. Lisitsyna1 , D. Veltishchev2 , O. Seravina2 , O.
effects on functioning. The aim of the study is to test these two
Kovalevskaya2 , E. Nasonov1 , V. Krasnov2
1 Nasonova Research Institute of Rheumatology, Vascular contrasting hypotheses.
Methods.– We evaluated the association of psychosocial function-
Rheumatology, Moscow, Russia; 2 Moscow Research Institute of
ing with copy number variants (CNVs) conferring risk for both
Psychiatry- NMRC PN MoH RF, Stress Related Disorders, Moscow,
autism and schizophrenia in healthy carriers (N = 139), and with
Russia
* Corresponding author. their autism and schizophrenia symptom expressions in individu-
als with first episode psychosis (N = 83) and schizophrenia (N = 174).
Results.– Across the three populations, autism and positive symp- patients;the discharge CPZEq-dose of SMISA -patients was 486.9 SD
tom expressions in the first episode and schizophrenia groups, and 324,1 vs. 366.1 SD 280.5 of SMINSA-patients. Moreover, we found
their genetic risks in healthy carriers are interactively associated the discharge LiEq-dose of SMISA-patients was 1234.5 SD 751.8 vs.
with psychosocial functioning, such that individuals with balanced 1190.0 SD 787.9 of SMINSA-patients. All SMISA-patients used BDZ
symptom expressions of/risks for autism and schizophrenia were at discharge (all p > 0.05).
associated with better functioning. Conclusions.– We found a tendency of SMISA-patients to have more
Conclusions.– The results suggest that some individuals may severe-general-illness vs. SMINSA-patients and,therefore,a more
present fewer psychosocial difficulties due to a balanced expres- homogenous-sample. Moreover, this is one of few studies evalu-
sion of autistic and psychosis liability. The results from the genetic ating acute-hospitalized-patients based on the RDoC-framework.
data suggest that this interaction is possibly mediated by the rela- Further, insight into the role of this conceptualization might help
tive dominance of genetic risk factors associated with autism and to ultimate the long-term-goal of the NIMH-RDoC-Initiative, such
psychosis spectrum disorders, and warrants further investigations as precision medicine in psychiatry.
of the protective effects of autism in psychosis spectrum disor- Disclosure of interest.– The authors have not supplied a conflict of
ders. The concurrent assessment of autism and psychosis may be interest statement.
necessary to predicting illness aetiology, prognosis and diagnostic
practices in both conditions.
interest statement. Multiple sclerosis and related
psychiatric syndromes
H. Medeiros, J.M. Coelho, A.B. Medeiros* , C. Peixoto, R. Rego
E-PP0255
Hospital do Divino Espírito Santo de Ponta Delgada, Psychiatry, Ponta
A framework based on the research Delgada, Portugal
domain criteria (RDOC) comparing * Corresponding author.
individuals with severe mental illness

Background and aims.– Multiple sclerosis (MS) is a degenerative
with and without history of child autoimmune disease of the central nervous system often associated
sexual abuse: clinical evaluation and with psychopathological symptoms and signs, such as complaint
characteristics of initial presentation before a definitive neurological diagnosis or
A. Amodeo* , A. Talamo, A. Riconi, L. Contini, N. Lisi, A. Ilaria, F. di more commonly with the progression of the disease. Psychiatric
Michele, P. Brogna, A. Paterniti, V. Infante, A. D’Argenio, G. syndromes are one of the main contributory factors for morbidity
Tarantino, M.L. Coviello, A. Facchi, L. Procenesi, A. Siracusano, C. and mortality associated with MS.
Niolu Methods.– Non-systematic review of the literature.
Università degli Studi di Roma Tor Vergata, Benessere della Salute Results.– Up to 60% of MS patients have a psychiatric disorder
Mentale e Neurologica- Dentale e degli Organi Sensoriali., Rome, Italy concomitantly. The pathophysiological relationship between these
* Corresponding author. comorbid entities remains unclear, and it is difficult to clarify
whether psychiatric disorders are indicative of the severity of the
Background and aims.– The DSM has been an invaluable tool in disease. In addition, both the disease process and the treatments
establishing reliability and creating a common language to facilitate involved may adversely affect the mental health of the patient with
communication about mental-illnesses. However, contemporary MS. Psychiatric syndromes with particular relevance in MS are:
neuroscience-research shows that current diagnostic-system is unipolar depression, bipolar disorder and anxiety. Unipolar depres-
not informed by recent scientific-breakthroughs. The NIMH-RDoC- sion is the most frequently associated psychiatric condition, with a
Initiative calls for the development of new ways of classifying prevalence of approximately 50%, being an important factor related
mental-disorders based on dimensions of observable behavior and to the risk of suicide, therefore, it should be systematically investi-
neurobiological-measures. gated. Although psychiatric comorbidity is common in MS patients,
Objective.– Clustering patients according to the RDoC-concept, we its incidence and prevalence remains poorly studied.
compared hospitalized-patients with severe-mental-illness and Conclusions.– Patients with MS have high psychiatric comorbidity,
child-history of sexual-abuse [SMISA]vs. those without [SMINSA] with emphasis on mood disorders. Thus, they require a multidis-
by clinical-evaluation and characteristics. ciplinary approach in the recognition and treatment of comorbid
Methods.– After written-informed-consent was obtained, we psychiatric conditions.
included 174-patients and, then, divided in two-groups: SMISA Disclosure of interest.– The authors have not supplied a conflict of
(n = 17,9.8%, Mean-age 41.3 SD 13.3 yrs;Women n = 15,88.2%) vs. interest statement.
SMINSA (n = 157, 90.2%, Mean-age 46.9 SD 14.9 yrs; Women n = 85,
54.1%). They were consecutively hospitalized (January–June2018)
at the Acute-Psychiatric-Unit “Policlinico Tor Vergata” Hospital, E-PP0257
Rome, Italy. The Brief-Psychiatric-Rating-Scale (BPRS), the DSMV- Effects of knowing the patient’s life
categorial-diagnostic evaluations and medical-records were used
story on the quality of the
to evaluate clinical-characteristics.
Results.– SMISA-patients had younger age at onset of psychiatric- doctor-patient relationship in
illness (26,62 SD 11.0), more violent-acts (n = 12, 70.6%), primary care
more patients with psychosis-spectrum-disorder-diagnosis (n = 9, L. Mehl-Madrona1 , B. Mainguy2
1 University of Maine, Graduate School, Orono- Maine, USA; 2
52.9%),more current-substance-use-disorder (n = 5, 29.41%) vs.
SMINSA-patients with a psychiatric-onset at 30.5 yrs (SD 13.31), University of Maine, Social Work, Orono- Maine, USA
violent-acts of 49,68% (n = 78), with psychosis in 43.9% (n = 69) of
the cases. SMISA-patients had more Medical-Comorbidity (64.7%
Background and aims.– The importance of the doctor-patient rela-
N11) than SMINSA-patients (61.8%, N97). Hospital-days were sim-
tionship in response to medications and in the placebo response
ilar (SMISA-patients 14.1 SD 7.2 vs. SMINSA-patients with 15.4 SD
is becoming more appreciated. Doctors with greater empathy have
9.6 days); The admission BPRS-score of SMISA-patients was 57.4 SD
greater mirror neuron activity. We set out to ask if the quality of the
11.8 vs. 66.2 SD 21.0 of SMINSA -patients; the discharge BPRS-score
of SMISA-patients was 33.1 SD 6.3 vs. 38.9 SD 12.0 of SMINSA-
doctor-patient relationship would improve if doctors knew their E-PP0259

patients’ life stories. Personality traits in a sample of
Methods.– Patients with chronic pain and anxiety and/or depres-
patients with drug-resistant epilepsy
sion were interviewed with the Northwestern University Life Story
Interview. Following the interview, they rated their relationship
in an epilepsy unit in Barcelona
with their doctor on the Doctor-Patient Relationship Questionnaire E. Monteagudo Gimeno1* , R. Sánchez-González1 , A.
- 16, as well as completing rating scales regarding their levels of Rodríguez-Urrutia2 , S. Herranz-Villanueva3 , A. Trabsa-Biskri1 , D.
pain (McGill Pain Inventory), anxiety (Zung Anxiety Inventory) and Sanagustin-Bosqued4 , L. Pintor-Pérez5
1 Institut de Neuropsiquiatria i Addiccions. Hospital del Mar. IMIM
depression (Center for Epidemiology Depression Scale). Doctors
rated their patients on the DPRQ-16 and completed the Jefferson Hospital del Mar Medical Research Institute., Department of
Empathy Scale. Then doctors were invited to read their patient’s life Psychiatry, Barcelona, Spain; 2 Consultation-Liaison Psychiatry Unit.
story. We collected the same data three more times at 3–4 month University Hospital Vall d’Hebron. CIBERSAM., Department of
intervals. Psychiatry, Barcelona, Spain; 3 Consultation-Liaison Service. Institut
Results.– The quality of the doctor-patient relationship improved de Neurociències. Hospital Clínic i Provincial de Barcelona.,
statistically significantly for both doctors and patients, though Department of Psychiatry, Barcelona, Spain; 4 Institut de
more for doctors, after reading the patients’ life stories. Doctors’ Neuropsiquiatria i Addiccions. Hospital del Mar., Department of
scores rose on average 0.8 points (p < 0.0001), while patients’ scores Psychiatry, Barcelona, Spain; 5 Consultation-Liaison Service. Institut
improved 0.6 points (p < 0.03). Improvement in the doctor-patient de Neurociències. Hospital Clínic i Provincial de Barcelona. Institut
relationship was correlated with reduction in the pain rating on d’Investigacions Biomèdiques August Pi i Sunyer IDIBAPS -
the McGill Pain Inventory (0.64, p < 0.047), the anxiety rating on Universitat de Barcelona. CERCA Programme/Generalitat de
the Zung (2.2; p < 0.019), and the depression rating (5.4, p < 0.016). Catalunya., Department of Psychiatry, Barcelona, Spain
Conclusions.– Knowing the patient’s life story improved the
doctor-patient relationship. This improvement was correlated with Background and aims.– Epilepsy is associated with increased preva-
reduction in depression ratings, anxiety ratings, and pain ratings. lence of psychopathology compared with general population and
Disclosure of interest.– The authors have not supplied a conflict of is present to a higher rate in drug resistant epilepsy (DRE), which
interest statement. makes treatment of DRE more complex, as it must not only focus
on achieving seizure-freedom, but also on managing of psychiatric
comorbidities amongst other complications (1).
E-PP0258
During years it has been investigated how epilepsy can affect the
The quality of liaison psychiatry neural circuits mediating personality (2). It has been shown that
written communication to accident seizures may negatively influence personality development and
and emergency can result in developing maladaptive personality traits (3). This can
D. Mirfin* , M. Clark, S. Liu, D. Deo be seen to a higher extent in patients with DRE, who could show
Surrey and Borders Partnership NHS Foundation Trust, Liaison more marked personality traits.
Psychiatry, Chertsey, United Kingdom AIM: To describe the personality profile of a sample of patients with
* Corresponding author. DRE from an Epilepsy Unit of Hospital Clinic in Barcelona during a
9-year period (2008–2016).
Background and aims.– The National Confidential Enquiry into Methods.– Retrospective study of 453 patients with DRE. Clinical
Patient Outcome and Death (NCEPOD) defined core standards that and sociodemographic variables were analyzed and patients com-
should be present within medical notes from Liaison Psychiatry. pleted the PDQ-4 questionnaire. Analyses were performed using
These include assessment of capacity, legal status, risk assessments SPSS Statistics.
and care plans. Results.– Sociodemographic and presence of axis I disorders and
We aimed to assess the quality of documentation within Accident results of PDQ-4 are shown in figure1.
and Emergency notes in two district general hospitals and obtained
data from feedback of these hospitals to determine how satisfied
they are with our documentation. The aim of this is to determine
areas of improvement and improve the quality of documentation.
Methods.– We completed two audits exploring the how compliant
Liaison Psychiatry entries within A&E notes with guidelines estab-
lished by NCEPOD. Each audit comprised of around 30 patients
within a two week period and only included working age adult
patients. We also requested feedback from referrers within A&E
specifically enquiring about their perception of the quality of doc-
umentation.
Results.– We noted in both samples that risk assessment and
plans are well communicated however areas which significant
improvement could be made included capacity and legal status and
providing a summary or formulation of the underlying difficulties. Figure 1. Sociodemographic and presence of axis I disorders and
We found that overall referrers were satisfied with written docu- results of PDQ-4.
mentation however were most concerned with areas concerning
risk and management plans. At times it also seemed that they were Conclusions.– The results from our sample show moderate and high
less sure about a patients legal status. levels of psychopathology in different subtypes of personality dis-
Conclusions.– Areas of improvement included mental capacity and orders, being particularly high (scores>30) in all the areas except for
legal status and what the expected action would be if a patient narcissistic, antisocial and dependent. They are in accordance with
attempted to leave A&E. As a result of this we introduced a proforma previous data (3,4) and suggest that the presence of abnormal per-
to improve documentation. sonality profiles in patients with epilepsy is high, being more severe
Disclosure of interest.– The authors have not supplied a conflict of in DRE. This implies an important concern as their recognition is
interest statement. essential in diagnosis and management as well as its presence can
affect the ability to treat the underlying epilepsy (4) and has great the real extent of addiction to benzodiazepines and its link with
impact on quality of life. self-threatening behaviors in psychiatric outpatients.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– We recruited 2813 psychiatric outpatients from 2011 to
interest statement. 2017, administering the BAS (Benzodiazepine Addiction Scale) and
the SHS (Self-Harming and Suicide Screening).
Results.– Most of the outpatients were affected by anxious disorders
E-PP0260 (59.5%), mood disorders (19.4%) and personality disorders (8.9%).
The effect of urinary incontinence and Their BZD prescriptions increased from admission to discharge
depression in elderly on the quality of (36.1% vs 54.0%, p < .0001). Patients who experienced tollerance
to BZD in the last year were 6.8%, sedation 8.8% and dependence
the life
17.4%, without significant differences among the main psychiatric
B. Nam
groups. Patients who experienced, in their lifetime, tollerance to
Konkuk University, Psychiatry, Chungju-si, Republic of Korea
BZD were 8.5%, sedation 10.6% and dependence 19.4%. 47.9% were
Background and aims.– Little is known about the influence of urinary positive for a problematic use of BZD in the lifetime. 3.5% of the
incontinence and depression on individual’s QOL (Quality of life). whole sample self-harmed during the last year and 3.5% attempted
We aimed to clarify how the interaction between urinary inconti- suicide, without significant differences among the main psychiatric
nence and depression influences one’s QOL. groups. During their lifetime, 8.5% of the whole sample self-harmed
Methods.– A total of 1262 patients were enrolled in this study. We and 11.8% attempted suicide. Moreover, there was a highly signif-
estimated the severity of depressive symptoms and QOL, using icant association between BAS positivity and self-harming in the
SGDS-K, EQ-5D. We also investigated the morbidity of urinary lifetime (p = .002).
incontinence for each patient in person or by questionnaire. Com- Conclusions.– An increase in BZD prescription and the evidence
parisons of QOL between groups with or without depression, with of a pathological use underline their addictive property, that
or without urinary incontinence were established using t-test, results transnosographic. Furthermore, the association between
ANOVA and Scheffe’s post hoc analysis. The interaction between BZD addiction and self-harming behaviors stress the importance
urinary incontinence and depression was analyzed by each domain of time-limited prescription and attention to addictive behaviors
of QOL, using multiple regression analysis. and interplay with self-harming in addicted.
Results.– Patients with depression and urinary incontinence Disclosure of interest.– The authors have not supplied a conflict of
showed significantly higher EQ-5D scores on every domain of QOL interest statement.
than other patients, which means significantly lower QOL. Patients
with depression, no urinary incontinence reported lower QOL,
especially in the domain of ‘usual activity’, ‘anxiety’ and ‘visual E-PP0262
analogue scale (VAS)’, whereas those with urinary incontinence, Bidirectionality between attention
no depression showed lower QOL in ‘motility’, ‘usual activities’ and deficit hyperactivity disorder and
‘pain’ domain. Statistically significant interaction effects of two dis- sleep disorders: what are the
eases were observed in the domain of ‘VAS’, ‘self care’ and ‘anxiety’.
implications?
Conclusions.– Comorbidity of urinary incontinence and depression
L. Ferreira1* , C. Ferreira2
showed significantly lower QOL of patients, compared with urinary 1 Hospital Distrital de Santarém, Departamento de Psiquiatria e
incontinence or depression respectively, which implies additive
Saúde Mental, Santarém, Portugal; 2 Centro hospitalar Lisboa Norte:
interaction effects of two diseases. Optimal diagnosis and treat-
Hospital Santa Maria, Psiquiatria, Lisboa, Portugal
ment of depression should be emphasized for patients with urinary * Corresponding author.
incontinence.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– Attention Deficit Hyperactivity Disorder
interest statement. (ADHD) is a common neuropsychiatric condition and sleep disor-
ders are an important comorbid conditions in adults with ADHD.
Sleep alterations associated with adulthood ADHD are poorly
understood. Our aim is to evaluate the relationship between ADHD
E-Poster Presentation: Comorbidity - Dual symptom severity and sleep alterations and to explore the potential
Pathologies - Part III/Neuroscience in Psychiatry - implications for treatment.
Part III Methods.– Literature research conducted using “PubMed” database
and search equation built using the MeSH terms “Attention Deficit
Disorder with Hyperactivity”, “Sleep Disorders, Circadian Rhythm”
E-PP0261 and “Sleep Wake Disorders”.
Addiction to benzodiazepines and Results.– The patient ADHD have several subjective complaints
of sleep. Some primary sleep disturbances, such as sleep apnea,
self-threatening behaviors
periodic limb movements, and circadian rhythm disturbances are
G. Bonfanti1 , E. Di Giacomo2* , D. La Tegola3 , F. Colmegna3 , E.
frequent comorbidities in ADHD. In adult ADHD, attention and
Biagi3 , F. Pescatore4 , M. Clerici1
1 School of Medicine and Surgery-University of Milano Bicocca, executive control are already compromised; therefore, insomnia
should be recognized and treated. The treatment of ADHD has a
Psychiatric Department, Monza, Italy; 2 ASST Monza-University of
variable effect on sleep, which depends not only on the drug, but
Milano-Bicocca, Psychiatry, Monza, Italy; 3 ASST Monza, Psychiatric
also on the nature of the disease. In addition, pharmacological and
Department, Monza, Italy; 4 Residency Program in
behavioral approaches to sleep have been shown to be effective in
Psychiatry-University of Milano Bicocca, Psychiatric Department,
alleviating some of the symptoms of ADHD.
Monza, Italy
* Corresponding author. Conclusions.– Both clinically significant ADHD symptoms and inat-
tention and hyperactivity symptom dimensions were consistently
Background and aims.– Benzodiazepines (BZD) are psychotropic associated with insomnia symptoms and altered sleep duration.
drugs which can cause addiction. The purposes of this study were Adults with ADHD should be assessed for sleep disorders, which
detecting the prevalence of BZD prescription, their problematic use is frequently comorbid, and both conditions should be treated.
and self-harming/suicide among abusers. We aimed at attesting The relationship is complex and bidirectional, being modulated by
interactions with the therapy used for ADHD and by psychiatric Results.– She presented a drug-seeking behaviour, tolerance and
comorbidities and their treatments. dependence phenomenon and intense craving which led to a
Disclosure of interest.– The authors have not supplied a conflict of state of depression during her stay in our unit. As it is known
interest statement. patients with borderline personality disorders tend to have a self-
destructive behaviour, which in this case, made it more difficult for
her to manage our objectives of stopping the substance abuse and
E-PP0263 the treatment of her mood disorders.
Quality of life and anxious depressive Conclusions.– It is important to keep in mind the comorbidities
disorders in patients with allergic that exist with the different psychiatric disorders, identifying in
this case our first diagnosis of eating disorder, personality disorder
contact eczema
and later on, substance abuse and mood disorders in order to be
A. Fki1* , A. Kchaou1 , N. Kotti1 , K. Jmal Hammami1 , A. Masmoudi2 ,
able to treat them all. The detection and control of the psychiatric
M.L. Masmoudi1 , M. Hajjaji1
1 Hedi Chaker Hospital, Occupational Medicine, Sfax, Tunisia; 2 Hedi comorbidity in our patient was a priority to be able to improve her
long-term outcome.
Chaker Hospital, Dermatology, Sfax, Tunisia
interest statement.
Background and aims.– Allergic Contact Eczema (ACE) is a common
skin disease that is progressive and disabling.
The purpose of our work was to assess the quality of life, anxiety E-PP0265
and depression in patients with ACE and to determine the factors Retrospective study of obstructive
associated with anxious-depressive disorders in these patients. sleep apnea (OSA) in an adult mental
Methods.– This is a cross-sectional study conducted among patients health community service
with ACE followed in the allergology unit of the Dermatology T.M.D.C. Gomes* , L. Marques, D. Fitzpatrick
department in Tunisia. Data were obtained using a pre-established Gorey Community Mental Health Services, Wexford, Ireland, Adult
form. This fact sheet included the socio-occupational data, clinical Psychiatry, Dublin, Ireland
data from the dermatological examination, the Arabic version of * Corresponding author.
Dermatology Life Quality Index (DLQI) to assess the impact of ACE
on quality of life, the Hospital Anxiety and Depressive Scale ques- Background and aims.– The common symptoms of obstructive sleep
tionnaire (HAD) to determine the level of anxiety and depression. apnea are: daytime sleepiness, fatigue, irritability and impaired
Results.– The predominant location was at the hand (86%). Almost cognitive function. Obstructive sleep apnea can mimic or exac-
two-thirds of the patients had acute eczema (75%). Chromium erbate symptoms of psychiatric disturbance such as depression,
was the predominant allergen in 37.5% of cases. The ACE had anxiety and panic disorders. It is associated with major depressive
a significant effect on quality of life in 72.9% of cases. Hand disorder and post-traumatic stress disorder.
eczema was associated with a significant effect on quality of life Methods.– Retrospective study in a mental health community, with
(p = 0.028). Patients with certain anxiety and depressive symptoms 340 patients. We searched through correspondence the terms
were 41.66% and 18.75% respectively. Anxiety was associated with “Obstructive Sleep Apnea” and “Epworth Sleepiness Scale” on active
the chronic form of eczema (p = 0.031) and hand eczema (p = 0.03). patients in the month of June 2018. 74 charts were identified.
Also, depression was associated with hand eczema (p = 0.02). Results.– In our sample (59% female, 41%male), there was more inci-
Conclusions.– Hand eczema has an impact on the quality of life with dence of obstructive sleep apnea in obese patients, male gender and
a repercussion on the emotional, psycho-social and relational level. smokers. Obstructive sleep apnea was associated with other medi-
Management of the hand eczema should also include psychological cal diseases, in particular hypertension and hypercholesterolemia.
counseling or psychotherapy. From a mental health perspective and in our sample it showed a
Disclosure of interest.– The authors have not supplied a conflict of higher incidence on patients with diagnosis of depression. From a
interest statement. medication perspective 30% of patients with sleep apnea diagnosis
were on regular SSRI. The prevalence of obstructive sleep apnea in
our sample was of 7%.
E-PP0264 Conclusions.– Is important to take obstructive sleep apnea as part
Case report of a young woman treated of a differential diagnosis once symptoms mimics depression.
in a specific hospitalisation unit for International data indicate that at least 4% of the middle aged adult
population has it. On our sample the prevalence was 8%, 4% more
patients with dual disorders
than the general population, which makes the differential diagnosis
S. Gamonal Limcaoco* , M.T. Lozano López, R. De la Mata Hidalgo,
of obstructive sleep apnea even more important.
N. Casado Espada, M.A. Garzon de Paz, A.I. Álvarez Navares, J. De la
Iglesia Larrad, R. De Alarcón Gómez, I. Valriberas Herrero, D.
interest statement.
Gonzalez Parra
Hospital, Psychiatry, Salamanca, Spain
E-PP0266
Background and aims.– This report presents the case of a 42-year-old Clinical and therapeutic aspects of
female diagnosed of an eating disorder and borderline personality premenstrual syndrome comorbid
disorder who asked for a voluntary internment in our specific hos- with panic disorder
pitalisation unit for patients with dual disorders due to her alcohol R. Iakimova1* , M. Stoianova1 , M. Stoimenova-Popova2 , P.
and benzodiazepine abuse and the misuse of sibutramine, phen- Chumpalova2 , I. Veleva2 , L. Tumbev2
termine and ephedrine, pills she would buy from the internet as a 1 Medical University, Psychiatry and Medical Psychology, Sofia,
compensatory behaviour. Bulgaria; 2 Medical University, Psychiatry and Medical Psychology,
Methods.– A retrospective collection of data from our patient’s clin- Pleven, Bulgaria
ical history and bibliographic review in the main search engines: * Corresponding author.
PUBMED and COCHRANE.
Background and aims.– Premenstrual syndrome (PMS) is often Disclosure of interest.– The authors have not supplied a conflict of
comorbid with panic disorder (PD). Selective serotonin re-uptake interest statement.
inhibitors (SSRIs) are treatment of choice in the management of
both PMS and PD when they occurred separately. PMS and comor-
bid PD often complicates the treatment. E-PP0268
Objectives.– (1) to evaluate the clinical symptoms of PMS and Psychiatric manifestations in
comorbid PD; (2) to assess the 6-month efficacy of SSRIs on the rheumatoid arthritis
symptoms of PMS. J. Jendoubi1* , A. Maamri1 , O. Zeriaa2 , H. Zalila1
Methods.– Longitudinal interventional study on the clinical symp- 1 Razi Hospital, the Outpatient Service of the Hospital Razi, Manouba,
toms of PMS and comorbid PD before and during the course of SSRIs Tunisia; 2 Military Hospital, Psychiatry, Tunis, Tunisia
treatment. We examined 30 women (mean age 31.2 ± 7.89) suffer- * Corresponding author.
ing from PMS and a current episode of PD, verified by means of PSST
and MINI, respectively. Background and aims.– Rheumatoid arthritis (RA) is an inflamma-
Results.– According to our results before treatment initiation the tory degenerative disease that restricts the patient’s daily activities
clinical symptoms were dominated by irritability (100%), mood and alters their quality of life, which in turn impacts mental well-
lability (90%), anxiety (90%), breast tension and tenderness, changes being that may worsen the course of the disease.
in appetite, headaches, and palpitations (100%), abdominal bloating The aim of this study is to critically evaluate and summarize current
(90%). Somatic symptoms were more than twice as common as psy- evidence on the different psychiatric manifestations of rheumatoid
chological. Only moderate and severe cases were present. After 6 arthritis reported in the medical literature.
months of treatment most of the above mentioned symptoms were Methods.– Review of the literature by research on the Medline
still present despite to a lesser degree of severity. Forty percent of database over a period from 1990 to 2018.
the women were completely recovered. Results.– The prevalence of anxio-depressive disorders in patients
Conclusions.– 1. The most prevalent symptoms in cases of PMS with RA varies between 13 and 48% in the studies. Depressive
and comorbid PD are irritability, mood lability, breast tension and comorbidity increases the symptoms common to RA. The inten-
tenderness, appetite changes, headaches, palpitations, abdominal sity of pain and the duration of morning stiffness are increased in
bloating. Mild cases are lacking. 2. Somatic symptoms are more patients with comorbid depression. In RA, sleep quality is impaired
prevalent being around twice as common as psychological. 3. SSRIs due to sleep fragmentation and is associated with an exacerbation
are an effective option for managing both somatic and psychologi- of pain perception and more marked disease activity. The reported
cal symptoms. fatigue in RA would be multifactorial, associated not only with dis-
Disclosure of interest.– The authors have not supplied a conflict of ease parameters but also with the physical, emotional, cognitive
interest statement. and social functioning of the patient. Psychiatric disorders may
be secondary to the treatment of RA, for example: corticosteroids
induce a lability of mood, irritability, anxiety, insomnia, cognitive
E-PP0267 disorders, confusion or sometimes psychosis; hydroxychloroquine
Quality of sleep in fibromyalgia induces a mood disorder, anxiety or psychosis. It would be prudent
J. Jendoubi1* , O. zeriaa2 , A. maamri1 , A. Tounsi amal1 , H. zalila1 , M. to consider these factors in the therapeutic management of RA.
haddad3 Conclusions.– Psychiatric manifestations comorbid with RA are
1 Razi hospital, the Outpatient Service of the Hospital Razi, Manouba, prevalent and may increase the quality of life of patients. Screening
Tunisia; 2 Military Hospital, Psychiatry, Tunis, Tunisia; 3 The Pain and treatment of psychiatric disorders improves the management
Treatment Center, la Rabta Hospital, Tunis, Tunisia of patients with RA.
interest statement.
Background and aims.– The clinical description of fibromyalgia is
enriched over the decades. Despite evidence of the impact of sleep
disorders on mood and quality of life, their evaluation in fibromyal- E-PP0269
gia is not systematic. Case presentation: affective disorder
The aim of this work is to study the quality of sleep in women with
in multiple sclerosis
fibromyalgia.
G. Kalpak* , B. Gjorgovska, Z. Babinkostova, S. Iloski, V. Zdravevska,
Methods.– This was a retrospective and descriptive study that took
B. Stefanovski
place at the Pain Treatment Center at La Rabta Hospital. Sleep qual-
University Clinic of Psychiatry, Biological Psychiatry, Skopje, FYR
ity was assessed using the Pittsburgh Sleep Quality Index (PSQI) in
Macedonia
25 patients followed for fibromyalgia according to the classifica- * Corresponding author.
tion criteria established by the American College of Rheumatology
(ACR). Background and aims.– The relationship between MS and affective
Results.– The mean age was 41 ± 2 years and 60% were married. On disorder is multi-factorial, complex and the underlying mecha-
the basis of PSQI, three quarters of the patients were “poor sleep- nisms are not clear encouraging further investigation. The growing
ers”. To the question “In the last month, how would you evaluate body of knowledge for multiple sclerosis gives hints that the affec-
the quality of your sleep? 64% rated their sleep as “pretty bad” or tive disturbances may be due to the demyelinating changes in the
“very bad.” The average time to fall asleep was 30 minutes. Sleep brain. MS most commonly goes with depressive symptoms or sub-
duration was greater than seven hours per night for 80% of patients. tle emotional disturbances that often don’t merit the criteria for
Sleep efficiency was greater than 85% in 56% of the cases. The most making a diagnosis. In this case presentation, we decided to report
commonly reported nocturnal sleep disturbances were: waking up a case of multiple sclerosis presenting with manic symptoms.
in the middle of the night (40%), coughing or snoring loudly (24%) Methods.– Here we present a 47 year old woman, diagnosed with
and having nightmares (28%). Nine of our patients used hypnotics 3 multiple sclerosis three years before the current admission to the
or 4 times a week. More than half of our patients reported daytime adult psychiatric ward. The primary diagnosis is confirmed via
fatigue (56%). CS fluid and MRI fulfilling the McDonald criteria for MS diagno-
Conclusions.– Further studies focusing on sleep disorders in sis. Previous psychiatric history is remarkable with one episode of
fibromyalgia with larger samples will be required to better address depression one year before admission. On admission, the patient
this important question. was euphoric with psychotic features, elevated mood, irritable. Few
weeks before admission she is reported to have increased sexual with post-traumatic stress disorder (PTSD). But this traumatiza-
desire, engaging with strangers over social media, planning semi- tion influenced a lot on the quality of successful adaptation and
nars, making travel arrangements, impulsively spending money. re-socialization during the deployment and in the postdeployment
Results.– On admission the patient was treated with antipsychotic period.
medication and psychostabilizer treatment was initiated. During Methods.– Were observed 128 postdeployment men participated in
the hospital stay, there has been marked reduction in the present- the military actions in eastern Ukraine for 0.5–4.5 years before the
ing symptoms. study with the Boston Assessment of TBI-Lifetime (BAT-L), Scale
Conclusions.– Differential diagnostic difficulties are encountered in for clinical diagnosis of PTSD (CAPS-5) and Sheehan disability scale
patients with MS when severe affective disturbances are present. (SDC).
The diagnosis of bipolar disorder is secondary to the primary diag- Results.– According to BAT-L 65.2% observed persons had at least
nosis of MS which proves as the candidate for the underlying cause one mTBI throughout their lives, especially 41.3% ones had at least
for the affective disorder. one military mTBI, with documentary evidence in only 19.8%. But
Disclosure of interest.– The authors have not supplied a conflict of 18.1% persons did not seek medical assistance at all. According to
interest statement. the CAPS-5 scale, 46.5% of patients with mTBI had also PTSD, and
42.1% had an adjustment disorder. Persons with mTBI and PTSD
comorbidity had the higher disability in comparison with mTBI and
E-PP0270 adjustment disorders comorbidity, and mTBI or PTSD along.
Connection between depressive and Conclusions.– Boston’s assessment of traumatic brain injury during
anxiety disorders and the rate of life (BAT-L), PTSD clinical diagnostic scale (CAPS-5) and Sheehan
disability scale (SDC) are useful for mTBI + PTSD management.
progression of HIV infection
A. Kaminska* , N. Kiriliuk
interest statement.
National Pirogov Memorial Medical University- Vinnytsya, Medical
Psychology and Psychiatry Department with the Course of
Postgraduate Education, Vinnytsya, Ukraine
E-PP0272
Analysis of stress-potentiating factors
Background and aims.– In recent years the world has witnessed in the dynamics of cerebrovascular
increased attention to mental characteristics of HIV-infected pathology development
patients. There is an increased risk of HIV infection among patients H. Kozhyna1* , M. Markova1 , T. Yavorska2 , I. Strelnikova1 , I.
with mental disorders and substance-dependent. Patients with Leshchyna1
mental disorders and receiving antiretroviral therapy (ART) typi- 1 Kharkiv National Medical University, Psychiatry- Narcology and
cally have problems with adherence, which can result in disease Medical Psychology, Kharkiv, Ukraine; 2 Kharkiv Medical Academy of
progression and formation of resistant strains of HIV. Postgraduate Education, Ultrasound Diagnostics, Kharkiv, Ukraine
Our aim was to investigate relationship between anxiety and * Corresponding author.
depressive disorders in HIV-infected patients and rate of disease
progression. Background and aims.– It is generally acknowledged that psychoso-
Methods.– Clinical method and psychological testing were used cial stress is one of the leading factors in the development of both
(Spielberger-Khanin Anxiety Test, Hamilton Depression Rating mental and somatic disorders, among which cardiovascular and
Scale). cerebrovascular pathology occupy the first place. Purpose: deter-
Results.– First group (G1) consisted of 62 patients with a CD-4 level mine the structure of stress risk factors in patients with different
of 70 to 220 cells/ml and requiring ART. Second group (G2) con- stages of the cerebrovascular pathology.
sisted of 72 patients with a CD-4 level of 370 to 780 cells/ml. In Methods.– 383 patients were examined: 122 -with cardiovascular
24 patients (45.2%) from G1 and in 20 patients (21.7%) from G2, diseases with clinically and laboratory confirmed high risk of the
one of depressive disorders was diagnosed. Average anxiety score cerebrovascular pathology, 134 patients with transient ischemic
in G1 was 47.4 ± 4.5 for reactive anxiety and 44.8 ± 6.5 for person- attacks, 127 patients who had suffered from ischemic cerebral
ality anxiety, in G2 - 36.9 ± 8.0 - reactive anxiety and 38.6 ± 0.5 - stroke. 47 healthy persons were examined as comparison group.
personality anxiety. HDRS score in G1 was 12 ± 2 and 6 ± 4 points To test the stress level the Boston Stress Test was used.
in G2. Consequently, higher rates of anxiety and depression were Results.– Pathological effect of psychosocial stress is realized
found in group with significantly lower immune status. through meaningfully different stress-potentiating factors depend-
Conclusions.– Results indicate higher levels of depression and anx- ing on the stage of development cerebrovascular pathology. The
iety in group with more rapid progression of HIV infection. First spectrum of stress-potentiating factors is transformed with the
group will be assigned to ART; and therefore, people with larger progressiveness of cerebrovascular pathology: at the initial stages,
manifestations of anxiety and depression may have trouble with the behavioral factors that are offset by the progression of the
adherence. disease have the biggest negative effect, giving way to psycho-
Disclosure of interest.– The authors have not supplied a conflict of emotional factors that contribute to progression and aggravation
interest statement. of the course of cerebrovascular pathology.
Conclusions.– The presence of a somatic disease is big stress-
potentiating factor that triggers a cascade of psychological,
E-PP0271 behavioral reactions from the side of the person. The direction of
Mild traumatic brain injury in the psychological response depends on personal, behavioral and
patients with PTSD psychosocial factors that, with favorable course of the adaptation
O. Khaustova1* , O. Smashna2 process in patients, in the dynamics, the cerebrovascular pathol-
1 Bogomolets National Medical University, Medical Psychology- ogy is oriented on changing the lifestyle to health-preserving, and
Psychosomatic Medicine and Psychotherapy, Kiyv, Ukraine; 2 in the case of unfavorable, it deepens existing distress and becomes
Ternopil State Medical University, Psychiatry, Киeв, Ukraine a source of psychological maladaptation.
interest statement.
Background and aims.– The mild traumatic brain injury (mTBI)
is often low diagnosed in combatants especially in combination
E-PP0273 overall of 8%(n = 14). 5% (n = 9) show signs of bulimia nervosa, Binge

Demographic profile of patients with eating disorder in total 7% (n = 12) and 7% (n = 12) are suffering from
dual diagnosis in Poland alcohol abuse.
M. Struzik1 , K. Wilczyński2 , J. Chałubinski1 , E. Mazgaj3 , K. Krysta3* Conclusions.– Medical students are more affected by depressive dis-
1 Upper Silesian Association “Familia”, Center for Addiction Therapy, orders (p < 0.05), while law and economics develop anxiety and
Gliwice, Poland; 2 Medical University of Silesia, Department of Child panic disorders. Academic overload which medical students are
and Adolescent Psychiatry, Sosnowiec, Poland; 3 Medical University more exposed to comparing to others can be one of the triggers of
of Silesia, Department of Rehabilitation Psychiatry, Katowice, Poland the developing symptoms. The presence of any affective disorder
* Corresponding author. helps to acquire bad drinking habits while studying.
Background and aims.– Dual diagnosis is a term describing co- interest statement.
occurrence of a mental disorder with a comorbid substance
abuse. Deinstitutionalization of psychiatric patients, despite obvi-
ous benefits, resulted in new challenges, such as social stigma, E-PP0275
deterioration of family life and social exclusion. Patients facing Eating disorder comorbidity in a
those obstacles on their way to recovery, resort to different meth- sample of personality disorder
ods of coping with them, inter allia drugs and alcohol beverages. patients ongoing day hospital
Our aim was to create a socialdemographic profile of patients with
dual diagnosis.
treatment
M. Torrijos Zarcero1 , N. Megías2 , P. Rosique3 , L. Valenciano3 , F.
Methods.– Study group was recruited from patients treated in a drug
Soler3 , L. Mellado Cuerno1*
rehabilitation centre of the Upper Silesian Association “Familia” 1 Hospital Universitario La Paz, Psychiatry- Clinical Psychology and
in Gliwice. The study group involved 100 patients, average age
Mental Health, Madrid, Spain; 2 Hospital Virgen de Altagracia,
equaled 29,7 years (min age 20, max age 48), and it consisted of
Psychiatry- Clinical Psychology and Mental Health, Ciudad Real,
9 females and 91 males.
Spain; 3 Hospital de día Francisco Román, Psychiatry- Clinical
Results.– Average age of introduction to psychoactive substances
Psychology and Mental Health, Murcia, Spain
was 20.4 years (95%CI: 14.9–25.8), and the lowest initiation age * Corresponding author.
was in case of alcohol (beer 13.9 years (95%CI: 13.3–14.6)) and the
higher in case of designer drugs (25.2 (95%CI: 19.7–25.9)). Primary Background and aims.– Research has demonstrated that Eating Dis-
motivation for undertaking treatment was a progressive deteriora- order (ED) is highly associated with Personality Disorder, and also
tion of a mental health and family pressure. that when associated symptomatology is more severe and progno-
Conclusions.– Patients included into our study used a plenty of dif- sis is much worse than if there is not comorbidity.
ferent drugs, usually in search of the substance that will improve Moreover, it has been found that individuals with an ED and Per-
one’s mental condition. It is worth noting that majority of partici- sonality Disorder may have poorer treatment outcome than those
pants planned to undertake a new job or raise their qualifications with Personality Disorder alone.
after treatment. Therefore rehabilitation programs should cover Methods.– We aimed to compare severity of clinical symptomatol-
reintegration and preparation of patients for future employment. ogy in Personality Disorder patients with and without ED.
Disclosure of interest.– The authors have not supplied a conflict of N = 41 patients in treatment at Hospital de Día Francisco Román
interest statement. because of Personality Disorder diagnosis. Our sample is only
composed by women. PD diagnosis = 48,48%; PD and ED diagno-
sis = 51,2%.
E-PP0274
This is a cross-sectional, naturalistic and descriptive study. We con-
Do medical students develop more ducted statistical analysis to compare severity in both groups before
addictions while studying in medical treatment started. We measured severity through Beck Depression
school? Inventory, State-Trate Anxiety Inventory, Global Severity Index of
S. Kuzmina* , E. Mukhametshina Mukhametshina, A. Valeeva, R. SCL-90- R questionnaire, Plutchik Risk Scales, among other indica-
Garipov tors.
Kazan State Medical University, Psychiatry, Kazan, Russia Results.– Significant differences were found in severity of symp-
* Corresponding author. tomatology between PD patients and PD-ED patients. Surprisingly,
results point out that PD patients without ED have more severe
Background and aims.– Medical school can be a period of a high symptomatology (more anxiety and higher suicidal risk).
stress and deterioration for students’ mental health. Our cross- However, the results of this study show that PD patients with ED
sectional study assesses the impact of stress on the formation of have more hospitalization admissions and stay hospitalized more
dependencies in the students of different programs: the general time than PD patients.
medicine faculty, law and economics and finances faculty students Conclusions.– Results are contrary to what previous research had
Methods.– 170 students: 64 medical, 31 economics and finance fac- suggested. It seems that in the comorbid group, symptoms are
ulty, 75 law. PHQ, PHQ-9, STAI, Mental status examination, habits focused on ED, while in PD group there are more diffuse symp-
and their attitude to smoking, drinking and using recreational drugs tomatology and higher risk of suicide.
questioner. We must continue investigating this issue and try to replicate these
Results.– More than a half of the surveyed students 73% (n = 124) surprising results.
presented minimal and mild level of depression, 14% (n = 25) Disclosure of interest.– The authors have not supplied a conflict of
presented moderate depression level, 6% (n = 10) and 4% (n = 6) interest statement.
have shown the level of moderately severe depression and severe
depression symptoms respectively. There are 17% (n = 30) who suf-
fer from major depressive symptom, among them there are 56%
(n = 17) medical students, 37% (n = 11) law, 7% (n = 2) economics
and finance. There are almost the same number 19% (n = 33) who
showed signs of other depressive syndromes. Panic syndrome
affects 12% (n = 20) of students. Other anxiety syndrome affects
E-PP0276 sion and anxiety risk; and 62% (n = 186, 95% IC 56.5–67.4) of
Depression and comorbide alexithymia risk. Overall treatment satisfaction was good.
cardiovascular diseases Conclusions.– The prevalence of depression, anxiety and alex-
B. Mykhaylov1* , V. Mykhaylov2 , V. Zabashta3 ithymia risk using the HADS and TAS-20 scale is among the highest
1 Kharkiv Medical Academy of Postgraduate Education, reported so far in medical literature. The prevalence of suicide risk
Psychotherapy, Kharkiv, Ukraine; 2 Kharkiv National Medical is higher than the general population and similar to previously pub-
University, Psychiatry, Kharkiv, Ukraine; 3 Kharkiv Medical Academy lished articles. This study supports the concept that psoriasis should
of Postgraduete Education, Psychotherapy, Kharkiv, Ukraine be approached in a multidisciplinary and systemic manner.
interest statement.
Background and aims.– The main objects of our research were:
To study clinical structure, patterns of development, pathophys-
iological formation mechanisms of somatogenic depression and E-PP0278
associated disorders in Myocardial infarction (MI) and Cerebral Spontaneous movement disorders in
stroke (CS) patients. first episode schizophrenia: a
Methods.– For conducting the research 120 patients were involved literature review and case study
and they were divided into 2 supervision groups (60 MI patients H. Raai1* , P. Manocha2 , P. Korenis2 , Y. Aronova3
and 60 CS patients). Examination was carried out in four stages: 1 Montefiore Medical Center- Albert Einstein College of Medicine,
acute phase, subacute phase, the recovery period, consequences Department of Psychiatry and Behavioral Sciences, New York, USA; 2
period. Throughout the period of the survey on the background of BronxCare Health System, Department of Psychiatry and Behavioral
basic therapy patients have been conducted by psychotherapeutic Sciences, New York, USA; 3 Saint Barnabas Health System,
correction and psychological support. Department of Psychiatry and Behavioral Sciences, New York, USA
Results.– Asthenic-depressive syndrome was observed in 33,3% * Corresponding author.
of patients, asthenic-anxiety in 23,3% of patients, asthenic-
hypochondriac in 13,3% of patients, phobic syndrome in 16,7% Background and aims.– The aim of this study is to review lit-
of patients, anozognostical disorders in 5,0% of patients. The erature of Spontaneous Movement Disorders (SMDs) in first
multimodal based system of psychotherapeutical correction of episode schizophrenia, exploring prevalence, and associations with
somatogenic depression depressive and associated disorders in schizophrenia and other psychotic disorders. We will also discuss a
MI and CS patients were developed. For MI patients this system case of a 24-year-old male who presented with SMDs and negative
includes personal - oriented, rational, and AT, for CS patients - hyp- symptoms as first episode psychosis. This case aims to illustrate
nosuggestive, cognitive - behavioral therapy, cognitive and AT. The the potential for exploring both psychiatric as well as neurological
proposed system demonstrated a significant improvement in 80% signs for unusual psychiatric presentations and aspires to add to the
of MI patients and 77% of CS patients, a partial improvement in 10% growing list of evidence for SMDs as atypical presenting symptoms
of MI patients and in 13% of CS patients. of psychosis.
Conclusions.– Among MI patients the pain syndrome is the main Methods.– Case study and literature search of the terms “Sponta-
one, leads to severe psycho-emotional disorders. Against the back- neous Movement Disorders”, and “Neurological Soft Signs” using
ground of cognitive function preservation phobic, anxiety and PubMed and selected relevant articles published in peer-reviewed
depressive symptoms prevail. Psychotherapy system decrease journals.
depression in 83% of patients. Results.– Neurological soft signs (NSS) are described as non-
Disclosure of interest.– The authors have not supplied a conflict of localized, minor sensory and motor neurological abnormalities that
interest statement. are not related to an impairment of a specific brain region. A grow-
ing body of literature suggesting NSS may also have diagnostic
significance in schizophrenia spectrum disorders. There have been
E-PP0277 a number of studies illustrating NSS in antipsychotic-naïve patients
Risk of depression, anxiety, suicide with psychotic disorders. This suggests that NSS may have clinical
and alexithymia in mexican value as a “non-mental sign” for schizophrenia spectrum disor-
ders. The positive finding of NSS correlated with the severity of
population with psoriasis
schizophrenia, non-response to conventional antipsychotics, more
A.P. Orozco Anahuati* , M.G. Olguín García, M.A. Morales Sánchez
negative symptoms, and poor prognosis.
Dermatologic Centre “Dr. Ladislao de la Pascua”, Dermatology,
Conclusions.– Physicians need to consider NSS in screening for first
Mexico City, Mexico
* Corresponding author. episode schizophrenia spectrum disorder. NSS as an initial presen-
tation of schizophrenia might be predictive of a poorer prognosis
Background and aims.– Psoriasis is associated with a myriad of and an indication for a more aggressive treatment approach to
psychiatric disorders that have an impact on disease severity, avoid a poor outcome.
life quality, response to treatment and cardiovascular risk among Disclosure of interest.– The authors have not supplied a conflict of
others. The objective is to determine prevalence of the risk of interest statement.
depression, anxiety, suicide and alexithymia, as well as treatment
satisfaction in patients with psoriasis in a Dermatology Center in
Mexico City (Dr. Ladislao de la Pascua) E-PP0279
Methods.– We included 300 patients with psoriasis. The follow- Neuropsychiatry aspects in space
ing questionnaires were applied: Hospital Anxiety and Depression travel
Scale (HADS), Plutchick Suicide Scale and Toronto Alexithymia O.E. Rodriguez Espinosa
Scale-20 (TAS-20). Socio-demographic and clinical characteristics, Royal Melbourne Hospital, Neuropsychiatry, Melbourne, Australia
comorbidities, severity in terms of Psoriasis Activity Severity Index
(PASI) and risk of joint involvement in terms of Psoriatic Arthritis Background and aims.– Human space travel is associated with
Screening Questionnaire (PASE) were assessed. numerous stressors such as radiation, microgravity, isolation, and
Results.– We found 9.7% (n = 29, 95% confidence interval (CI) confinement just to name a few.
6.3–13.0) of suicide risk; 48% (n = 144, 95% CI 42.3–53.6) of depres-
Many scholars have published scientific articles describing the Hospital stay (mean-days): 25.1 for hyperhomocysteinemia with
human biological, psychological and psychiatric changes associated low folic acid and/or Vitamin B12; 19.8 for isolated hyperhomo-
with space flight. cysteinemia; 16.1 for normohomocysteinemia.
Understanding the neuropsychiatry aspects of human space mis- Conclusions.– The predominance of hyperhomocysteinemia not
sions is pivotal and crucial, given the complex interaction between related to vitamin B12 and folic acid deficiency suggests that other
the neuropsychological and psychiatric factors with biological, factors might be relevant. Hyperhomocysteinemia was associated
sociocultural factors in space’s unique and hostile environment can with longer hospital stays compared to patients with normoho-
compromise space missions. mocysteinemia, suggesting that hyperhomocysteinemia might be
This literature review aims to raise awareness of neuropsychia- a treatment response/prognostic factor in psychiatric patients.
try risk in space travel, as well as identifying critical studies and Disclosure of interest.– The authors have not supplied a conflict of
research gaps. interest statement.
Methods.– A thorough literature review of the Neuropsychiatry
aspects of space travel on humans. The review was based on
academic articles published over the last decade that focuses on E-PP0281
various biological, psychological and social-cultural dimensions of The role of MPH on normalizing dmn
space travel on astronauts. The paper adopts Engel’s Biopsychoso- function in ADHD - a systematic
cial model as the framework when explaining the neuropsychiatry
review
aspects of space flight.
P. Santos* , R. Gonçalves, S. Pedroso
Results.– A holistic approach of assessing an astronaut’s mental
Centro Hospitalar e Universitário de Coimbra, Child and Adolescent
health is proposed using the biopsychosocial model. Radiation,
Psychiatry, Coimbra, Portugal
microgravity, and immunological changes increase the neuropsy- * Corresponding author.
chiatry risks in deep space exploration.
Conclusions.– One of the literature gaps identified is the lack of Background and aims.–
research around problems related to mood and psychotic disorders Introduction.– Methylphenidate (MPH) is a first-line agent
in deep space exploration. Further research is warranted in differ- with strong efficacy evidence for the treatment of Attention
ent areas to help understand and evaluate the neuroinflammatory Deficit/Hyperactivity Disorder (ADHD). Among the altered neural
responses occur during a long-term mission and the adjustment networks proposed to be affected in ADHD is Default Mode Net-
reaction in short-term missions. This facilitate the formulation of work (DMN). DMN is a set of midline brain regions which usually
protocols in addressing psychiatric emergencies in Space travel. deactivates under the execution of external tasks. DMN deactiva-
Disclosure of interest.– The authors have not supplied a conflict of tion failure under those circumstances was found in ADHD patients.
interest statement. This failure was also associated with poor performance on working
memory and inhibitory control tasks.
Objectives: To determine whether an association between MPH
E-PP0280 administration and DMN functioning in ADHD patients exists and,
High homocysteine serum levels as if an association is found, whether it correlates with neuropsycho-
possible treatment logical tasks performance.
response/prognosis factor in Methods.– We conducted a systematic review on the effects of
MPH in DMN activity in ADHD patients. For eligibility, studies were
psychiatry
required to assess the effects of MPH administration on DMN func-
M. Sales* , A. Silva-dos-Santos
tion and to include ADHD patients’ samples.
Hospital Vila Franca de Xira, Psychiatry, Vila Franca de Xira, Portugal
* Corresponding author. Results.– After a systematic search, seven studies fulfilling the inclu-
sion criteria were included in this review. Five studies evaluated the
Background and aims.– performance on neuropsychological tasks. DMN activity was mea-
Introduction.– Hyperhomocysteinemia has been associated with sured by fMRI in five studies, steady-state visual evoked potential in
neurological and psychiatric disorders. Although low folate and one study and by EEG in another. Six studies showed deactivation of
vitamin B12 levels are frequently linked to hyperhomocysteine- DMN related brain areas while another failed to show a significant
mia, they are not the main causes. Being neurotoxic, homocysteine difference. When assessed, neuropsychological tasks performance
might be related to treatment response and/or prognosis of psychi- improved after MPH administration.
atric patients. However, this association is not fully understood. Conclusions.– Our results suggest that MPH improves the DMN
Objectives.– To assess serum levels of homocysteine in acute psychi- dysfunction in ADHD, by increasing DMN deactivation. The
atric patients and its possible association with folic acid and vitamin improvement seems to be associated with symptoms severity
B12 serum levels, age, race, sex, diagnosis and hospital stay. decrease.
Methods.– Analysis of 266 consecutive medical records of patients, Disclosure of interest.– The authors have not supplied a conflict of
with homocysteine serum levels, admitted in Vila Franca de interest statement.
Xira Hospital’s Psychiatric Department, between January 2015-
December 2017.
Results.– Population: 266 patients. 43.61% (n = 116) male; 56.39% E-PP0282
(n = 150) female. Mean age: 46.6 year-old (16–89). Tourette disorder and
A wide spectrum of psychotic and affective disorders were obsessive-compulsive disorder:
included. re-examining the relationship
Serum Levels.– C. Sereijo* , M.J. Gonçalves, R. Saraiva, C.L. Rodrigues, R. Santos, R.
Homocysteine: 75.19% (n = 200) hyperhomocysteinemia vs 24.81% Barandas
(n = 66) normohomocysteinemia; 78,9% (n = 142) with hyperhomo- Centro Hospitalar Lisboa Norte - EPE, Psychiatry and Mental Health,
cysteinemia had normal Folic Acid/B12 Vitamin. Lisbon, Portugal
Vitamin B12: 6.77% (n = 18) deficiency vs 85.34% (n = 227) normal * Corresponding author.
levels; 7.89% levels not available (NA);
Folic acid: 10.90% (n = 29) deficiency vs 80.45% (n = 214) normal Background and aims.– Tourette disorder (TD) is a a neuropsy-
levels; 8.65% NA. chiatric movement disorder and is often accompanied by specific
behavioral problems such as obsessions, compulsions, hyper- 2017): bilateral high signal around the temporal horn, and diffu-
activity, distractibility, and impulsivity. Research suggest that sion abnormality, suggestive of encephalitis. PCR and Anti- NMDAR
an important number of TD patients develop clinical levels of antibodies: negative. Anti-VGKC: positive. Patient was treated with
obsessive-compulsive disorder (OCD). levitiracetam and prednisolone.
The aim of this review is to analyze the distinctions and similarities Conclusions.– It is important to consider the possibility of anti-VGKC
between Tourette disorder and obsessive–compulsive disorder and encephalitis in all patients with new-onset psychosis or mania.
its impact in clinical practice. Red flags include neurologic symptoms such as facial twitching,
Methods.– A literature review was conducted using the PubMed seizures, confusion, and cognitive decline.
search database. Disclosure of interest.– The authors have not supplied a conflict of
Results.– The similarities between repetitive movements that are interest statement.
a manifestion of chronic tic disorders such as TD and repetitive
behaviors characteristic of OCD makes a precise clinical differen-
tial diagnosis necessary. There is an important correlation between E-PP0284
both entities, many patients who suffer from TS also suffer from New approaches to molecular
OCD and vice versa. modeling anticonvulsant
In most cases making a differential diagnosis between tics and OCD
meta-chlorobenzhydryl urea
is relatively easy after a correct symptom recognition. However
there are borderline forms, and correct symptom recognition is (m-ClBHU) on neuronal GABAA
crucial for choosing an appropriate treatment strategies for each receptor and new perspectives in
disorder, which includes the pharmacological, psychotherapeutic psychopharmacotherapy
or brainstimulation aproach. T. Shushpanova
Conclusions.– A correct understanding of the contributions of both Mental Health Research Institute of Tomsk National Research Medical
tics and behavioral problems in patients’ health-related quality of Center, Addictive State Disorders, Tomsk, Russia
life is crucial in formulating an appropriate targeted management * Corresponding author.
plan.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– The study of the effects of chemical sub-
interest statement. stances that have a modulatory effect on neuronal GABA receptor
(GABAAR) will make it possible to develop new approaches to
treatment of alcohol dependence. New approaches to molecular
E-PP0283 modeling have allowed the use of computer-aided design of new
Limbic encephalitis with anti- VGKC chemical substances based on the mechanism of their action or
structure.
receptor antibodies: a case of a
Methods.– For docking, a model crystal structure of the ␣1␤2␥2
53-year man with no previous receptor GABA receptor heteropentamer optimized to study the
neuropsychiatric history presented interaction of GABAAR with agonists and allosteric modulators that
with manic symptoms and delusional bind to the GABAAR site at the benzodiazepine site was used.
disorder Results.– Known agonist of the GABAAR Carbamazepine and m-
H. Shahpesandy1* , R. Mohamed-Ali1 , U. Ramaiah2 , T. Al-Kubaisy2 , ClBHU were used to build the model by a high degree of compliance
A. Oladosu3 , A. Turan3 with the model - 0.745 and 0.651, respectively. Thus, taking into
1 Lincolnshire NHS Foundation Trust, The Hartsholme Centre, Lincoln, account the calculated values of the degree of conformity of
United Kingdom; 2 Lincolnshire NHS Foundation Trust, Peter the compounds of the pharmacophoric model of the barbiturate
Hodgkinson Centre, Lincoln, United Kingdom; 3 Lincolnshire NHS binding site on the GABAAR, one can say that m-ClBHU and Carba-
Foundation Trust, Pilgrim Hospital, Boston, United Kingdom mazepine are low complementary to the barbiturate binding site
* Corresponding author. on the GABAAR and probably interact poorly with it. The molecule
m-ClBHU proved to be complementary to the benzodiazepine site
Background and aims.– Limbic encephalitis represents a group GABAAR and interacts with key amino acids on the ␣1␥2 receptor
of autoimmune conditions, and its key symptoms are a severe interface.
impairment of short-term memory and psychiatric symptoms, as Conclusions.– Our studies confirm our data on the modulation of
psychosis and mania. the properties of benzodiazepine receptors on the GABAA receptor
We aim to present a case of 53-year old gentleman, with poor complex in the rat cerebral cortex during experimental alcoholism
English who initially presented with symptoms of mania and delu- by increasing the receptor affinity (1).
sional disorder. 1. Shushpanova TV1, Solonskii AV, Novozheeva TP, Udut VV. Meta-
Methods.– A 53-year old Latvian gentleman with no previ- chlorobenzhydryl urea (m-ClBHU) on the benzodiazepine receptor.
ous neuropsychiatric history was admitted to the psychiatric Bull Exp Biol Med. 2014, 156(6):813-8. doi:10.1007/s10517-014-
intensive care unit on 10th September 2017 following a sub- 2458-4.
acute deterioration of his mental health; physically aggressive, Disclosure of interest.– The authors have not supplied a conflict of
elevated in mood, paranoid-persecutory and grandiose delu- interest statement.
sions. No cognitive deficit, no neurological symptoms. Psychosis
effectively manged with zuclopenthixol deaconate due no non-
compliance with oral medication, and on 25th October transferred E-PP0285
to acute psychiatric ward with diagnosis of persistent delusional Hypernatraemia and mental activity
disorder. Y. Sidneva* , L. Astafyeva, M. Kutin, P. Kalinin, I. Klochkova
On 10th November 2017, he had a four-minute grand mal seizure. N.N. Burdenko National Medical Research Center of Neurosurgery,
On further assessment, cognitive decline, and severe short-term Neurosurgery, Moscow, Russia
memory noted; Addenbrooke’s Cognitive Examination: 55/100. * Corresponding author.
Results.– Normal ECG, neutrophilia 9.14 × 109 , ALT 65 umol/l, GGT

−83 umol/l, Prolactin 388 mIU/l, and Vitamin B12-184 ng/l. CT head Background and aims.– Electrolyte disbalance affected on mental
(14th September, and 8th November 2018): normal. EEG and lum- disorders, their structure and dynamics in the literature has not
bar punction (November 2017): normal. MRI head (21st November been sufficiently studied. Perhaps there are certain factors and
patterns of the influence of hypo- and hypernatraemia on mental Conclusions.– Neurophysiological data point that in patients pro-
activity with various lesions of the brain, which requires study. cesses of excitation and inhibition are simultaneously present
Purpose.– To study the effect serum sodium concentration on men- predominantly in the anterior brain areas that is physiologi-
tal disorders on the model of a benign tumor of craniopharyngioma. cally paradoxical and can be explained by the disturbance of
Methods.– 89 patients (18–65 years) after removal of craniopharyn- neurotransmitters–GABA, glutamate and dopamine- function
giomas in the early postoperative period. Psychopathological, data Disclosure of interest.– The authors have not supplied a conflict of
of endocrinological, neurological, neuroimaging. Serum sodium interest statement.
concentrations are norm of 135–145 mmol/l.
Results.– 1 group - 43 patients (48%) with hypernatraemia: endo-
suprasellar (10%), suprasellar (35%), extra-intraventricular (45%) E-PP0287
and intraventricular (10%) craniopharyngiomas. Group 2 - 46 Association between schizophrenia,
patients (52%) with normal serum sodium concentration: endo- cognitive disorders and vitamin d
suprasellar (39%), suprasellar (37%), extra-intraventricular (11%)
serum level: review
and intraventricular (13%) craniopharyngiomas. Productive symp-
R. Trabelsi* , H. Ben Ammar, A. khalifa, A. Aissa, Z. Elhechmi
toms were in 80%: motor excitement, affective disorders, delirium,
Razi Hospital, Psychiatry F, La Manouba, Tunisia
visual hallucinations, amnestic confusion. These disorders occurred * Corresponding author.
in patients with hypernatraemia more often (p < 0.001) (group 1)
than in patients with normal serum sodium concentration (group Background and aims.– Vitamin D deficiency has been identified
2). There was a subgroup of patients with persistent long hyper- as a global problem. Approximately 14% of the world population
natraemia (lasting more than 5–7 days) in 22 patients (51%). There has inadequate vitamin D levels. This vitamin may be an important
were negative (deficient) symptoms: Korsakov’s syndrome, apa- factor in the development of psychiatric illnesses, therefore clini-
thy, increased drowsiness in 15 patients (68%). It was significantly cians should not leave this serious issue unresolved. The aim of this
more frequent (p < 0.001) compared to patients with normal serum review is to describe the current data concerning the association
sodium concentration. between vitamin D serum levels, cognition and mental disorders.
Conclusions.– Serum sodium concentration affects a person’s men- Methods.– We conducted a systematic bibliographical research, of
tal activity. Hypernatraemia can be a factor that causes productive PubMed, MedLine literature and Cochrane database without lan-
symptoms and syndromes of mental disorders and adversely guage restriction to identify all publications concerning this issue
affects their dynamics. from 2012 to the first quarter of 2017.
Disclosure of interest.– The authors have not supplied a conflict of Results.– We found 85 articles concerning vitamin D and
interest statement. schizophrenia, published during the last 5 years. We selected only
those publications focused on the association between vitamin D
serum deficiency and cognitive disturbances in schizophrenia. Fif-
E-PP0286 teen papers were found suitable to our selection criteria. Careful
Paradoxical neurophysiological evaluation of the relevant literature demonstrates that addition of
manifestations of schizophrenia vitamin D to antipsychotic (Clozapine) was associated with a trend
V. Strelets1* , A. Arkhipov Arkhipov1 , G. Rodionov Arkhipov2 , V. towards improved cognition, but did not affect psychosis, mood or
Ushakov Arkhipov3 metabolic status.
1 IHNA&NPh RAS, Laboratory of Human Higher Nervous Activity, Conclusions.– In order to recommend supplementation of vitamin
Moscow, Russia; 2 IHNA&Nph of RAS, Laboratory of Human Higher D as a standard therapeutic attitude, more randomized placebo-
Nervous Activity, Moscow, Russia; 3 NRC “Kurchatov Institute”, controlled studies should be performed with definite results
Department of Medical Physics, Moscow, Russia showing its efficacy.
interest statement.
Background and aims.– The study was aimed at analysis of complex
neurophysiological and neuroimaging data in paranoid schizophre-
nia patients, which is important for schizophrenia pathogenesis E-PP0288
understanding. Microstructure features of the brain
Methods.– Visual ERPs to neutral and emotionally negative (threat-
as a possible etiopathogenetic cause
ening) pictures taken from IAPS were studied in 39 paranoid
schizophrenics and 43 healthy subjects. Neuroimaging studies of the clinical heterogeneity of
were done in the same patients with the same stimuli. endogenous psychoses
Results.– In both groups activation to more significant emotionally G. Mamedova1 , V. Ushakov2* , D. Kutovoy3 , N. Zakharova3 , S.
negative stimuli was higher than to the neutral ones in occipital Kartashov2 , V. Orlov2 , A. Vartanov4 , M. Sharaev5 , G. Kostyuk6
1 Lomonosov Moscow State University, Faculty of Fundamental
and temporal areas. This effect occurred in 200 ms after stimulus
presentation in the right hemisphere, in 300 ms - in the left hemi- Medicine, Moscow, Russia; 2 NRC «Kurchatov Institute», department
sphere, and in 400 ms–again in the right hemisphere. However, in of neurocognitive technologies, Moscow, Russia;3 State Healthcare
patients in 200 ms along with the higher activation during percep- Institution «Psychiatric Clinical Hospital 1 n. a. N.A. Alekseev of
tion of the threatening stimuli simultaneous increase of both P200 Healthcare Department of Moscow», The educational center, Moscow,
amplitude and latency took place in the left temporal area and in Russia; 4 Lomonosov Moscow State University, Department of
the right frontal and central areas - their simultaneous decrease. We Psychophysiology, Moscow, Russia; 5 Skolkovo Institute of Science
called this phenomenon “paradoxical effect”. In 300 ms such effect and Technology, Center for Computational and Data-Intensive
took place also in the left frontal and in 400 ms–in both prefrontal Science and Engineering, Skolkovo- Moscow region, Russia; 6 State
areas. Healthcare Institution «Psychiatric Clinical Hospital 1 n. a. N.A.
Neuroimaging analysis showed that healthy subjects “automat- Alekseev of Healthcare Department of Moscow», Head doctor,
ically” exclude the neutral stimuli from further analysis as Moscow, Russia
non-significant ones. In patients this does not happen and they
additionally have to use their voluntary attention resources which
Background and aims.– There are two hypothesis of schizophre-
are limited.
nia according to the numbers of studies of brain anatomy in
schizophrenic patients: neuro-ontogenetic and neurodegenerative. anti-NMDAR encephalitis; psychiatry requested appropriate diag-
To date there is still no compelling data of damage or deteriora- nostic evaluation including EEG, MRI, LP, and pelvic ultrasound.
tion of brain development due to the early onset of the disease. After a positive ultrasound with suspicion of teratoma that was
This study of brain microstructure (in particular gyrification) confirmed by pelvic MRI, the patient received high dose steroids,
and pathocharacterological traits, some of which are constitu- IVIG and bilateral ovarian cystectomy. Despite initiation of first-
tional, would make our understanding of the etiopathogenesis of line therapy, her clinical condition continued to decline, requiring
schizophrenia better. transfer to a specialized hospital.
Methods.– In vivo study of human brain’s microanatomy and Conclusions.– Anti-N-methyl-d-aspartate (NMDA)-receptor
characterological features, as mostly congenital characteristics, in encephalitis is a multi-faceted syndrome with neuro-psychiatric
patients with psychotic disorders compared to healthy individuals. features that can be misdiagnosed as substance abuse disorder.
The sample include 40 patients, 18–40 years old, with a verified We encourage a multidisciplinary approach and consideration
diagnosis of paranoid, catatonic schizophrenia and 21 healthy vol- of immediate treatment with cases of high clinical suspicion,
unteers. although confirmatory diagnosis is pending.
Tractographic reconstruction of neural connections was made by Disclosure of interest.– The authors have not supplied a conflict of
DTI with the subsequent calculation of matrices of connectivity of interest statement.
the brain areas in accordance with AAL atlas. The factor analysis
with Cattle’s criterion and following comparative analysis using the
t-test were performed to the matrix. E-PP0290
Deep analysis of the brain zones anatomy was made by FreeSurfer. A cross-sectional study of caregiver
Pathopsychological assessment performed using PBQ, 5PFQ, burden and its correlates in caregivers
TEMPS-A and ANNOVA. of chronic kidney disease patients
Results.– Three factors described motor functions and limbic system
on tractographic reconstruction were identified that revealed sta-
undergoing haemodialysis
S. Bhandari MD1* , S. Joseph1 , S. Dutta1 , D. Khatri2
tistically significant differences in the patients and healthy control 1 Sikkim Manipal Institute of Medical Sciences, Department of
group. Deep analysis of the brain zones is underway. No significant
Psychiatry, Gangtok, India; 2 Sikkim Manipal Institute of Medical
differences in characterological traits were obtained.
Sciences, Department of Medicine, Gangtok, India
Conclusions.– Based on preliminary data, hypothesis about the het- * Corresponding author.
erogeneity of the mechanisms of development of psychosis can be
proposed. Data processing is underway, the results will be shown Background and aims.– Caregivers face a lot of adversities while
at the congress. supporting their near ones undergoing haemodialysis and their
Disclosure of interest.– The authors have not supplied a conflict of burden is often ignored by health professionals. Paucity of research
interest statement. in Indian context has kept their needs out of sight.
Aims and objectives.– To assess the caregiver burden in caregivers of
patients with chronic kidney disease (CKD) undergoing haemodial-
E-Poster Presentation: Consultation Liaison ysis, socio-demographic and patient related variables affecting
Psychiatry and Psychosomatics - Part I caregiver burden and to assess the relation between patient depres-
sion and caregiver burden.
Methods.– 51 patients and their caregivers from two dialysis
units in Sikkim were assessed. Zarit Caregiver Burden Scale
E-PP0289 (ZCBS) was administered to measure the Caregiver Burden. Patient
Substance use bias delays Health Questionnaire (PHQ-9) and Charlson’s comorbidity index
(confounding) diagnosis and assessed patient’s depression and medical comorbidities respec-
treatment of ANTI-NMDAR tively. Descriptive analysis was done for the socio-demographic
and clinical variables. Chi square test was used to find the asso-
encephalitis
ciation between the categorical data. Kruskal-Wallis tested the
R. Babalola1* , F. Oluyadi2 , K.R. Kaufman1
1 association between categorical and quantitative variables.
Rutgers, Psychiatry, New Brunswick, USA; 2 Rutgers, Familyl
Results.– Mean age of patient was 46.13 (±13.15) years and that of
medicine, New Brunswick, USA
* Corresponding author. the caregiver was 44.78 (±12.14) years. 68.6% of caregivers had mild
to severe levels of caregiver burden. Mean duration of dialysis was
Background and aims.– Anti-N-methyl-d-aspartate receptor (anti- 19.92 (±15.4) months. Caregivers who were unemployed, educated
NMDAR) encephalitis is a common autoimmune encephalitis till secondary school were more likely to report caregiver burden.
characterized by autoantibodies produced against NMDA recep- Female gender, older caregivers and caregivers attending patients
tors. Prominent psychiatric symptoms in the absence of neurologic with longer history of hemodialysis reported more severe burden.
symptoms have led to misdiagnosis in multiple cases. There is lim- Conclusions.– The level of burden in caregivers is significant and
ited literature addressing how false positive toxicology confounds is affected by various factors and in turn also affect patient’s well
anti-NMDAR encephalitis diagnosis. This case report is a further being. Further research in this area is needed in our country for
example of how delayed diagnosis and treatment with positive better management of patients and policy making.
urine toxicology may lead to increased morbidity. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– Case analysis with PubMed literature review of anti- interest statement.
NMDAR encephalitis and co-morbid substance usage.
Results.– A 20-year-old female presented with altered mental sta-
tus (AMS). Initial laboratories were unremarkable excluding mild E-PP0291
leukocytosis and positive urine toxicology for amphetamines (false Suicidality following hsv encephalitis:
positive with ranitidine). Neurology noted no focal findings, con- a case report
sidered a witnessed tonic-clonic seizure to be a pseudoseizure, and D. Bieber1* , E. Bieber2 , K. Miller2 , U. Camsari2
cleared the patient for psychiatric care. Psychiatric consultation 1 Mayo Clinic, Neurology, Rochester, USA; 2 Mayo Clinic, Psychiatry
with collateral history from family revealed an acute onset AMS and Psychology, Rochester, USA
with rapid deterioration that progressed even after neurological * Corresponding author.
clearance. Psychiatric diagnosis was delirium with consideration of
Background and aims.– Despite improvements in treatment, 40–60% were not correlated with other variables. A stepwise regression
of herpes simplex virus (HSV) encephalitis survivors display behav- analysis revealed that resilience was the only variable contributing
ioral and personality changes. There is a dearth of literature significantly to the calculation of BAI score, even after controlling
describing suicidality following HSV encephalitis. This case aims for the effect of age, gender, duration and severity of psoriasis, as
to add literature on psychiatric outcomes of HSV encephalitis. well as comorbidity with other physical illness.
Methods.– Mrs. G was evaluated by each of the authors. Literature Conclusions.– Psoriasis is a psychodermatologic condition requir-
of known sequela of HSV was reviewed. ing a multidimensional therapeutic approach. The evaluation and
Results.– Mrs. G, a 63-year-old high functioning nurse with no treatment of anxiety symptoms is essential for improving dis-
significant medical or psychiatric history, was hospitalized for order’s global outcome. Resilience may moderate severity of
febrile illness with altered mental status and diagnosed with anxiety symptoms. Therefore, resilience-oriented interventions
HSV encephalitis by cerebral spinal fluid (CSF) polymerase chain could either prevent the emergence, or alleviate established anxiety
reaction (PCR). Acyclovir was initiated and continued for 3 symptoms.
weeks. Magnetic resonance imaging (MRI) demonstrated bilat- Disclosure of interest.– The authors have not supplied a conflict of
eral mesiotemporal lobe changes more pronounced on the right, interest statement.
a well-established finding of this illness associated clinically with
anterograde amnesia, which persisted despite improvement in
mental status. Discharge was inhibited by suicidal ideation and E-PP0293
gestures, which the patient did not recall, with no evidence of a Consultation-liaison psychiatry and
psychiatric disorder. Collateral information revealed a significant length of stay in the general hospital:
change in personality, including chronic irritability and histrionic
a pathway analysis
symptoms, for which antidepressant trials were unhelpful. Mood
M. Brunn1* , J. Strain2 , A. Diefenbacher1
stabilization with valproate also showed minimal benefit. Psychi- 1 KEH Hospital, Psychiatry, Berlin, Germany; 2 Mount Sinai Hospital,
atric hospitalization was of little utility as the patient could not
Psychiatry, New York, USA
participate in unit programing and could not learn new material. * Corresponding author.
Mrs. G was discharged home with 24-hour supervision. One-year
follow-up revealed an improved cognitive assessment but ongoing Background and aims.– As health systems are overhauling hospi-
suicidal statements and irritability. tal payment systems and organization, there is renewed interest in
Conclusions.– Despite improved mortality, morbidity due to psy- the role of consultation-liaison psychiatry (CL). While early studies
chiatric sequela of HSV encephalitis remains extremely impairing suggest that timely consultations are associated with shorter length
with poor treatment outcomes. Suicidality may be part of this pre- of stay (LOS), subsequent reviews questioned this. Recent analyses
sentation. have addressed further interactions between factors that are asso-
Disclosure of interest.– The authors have not supplied a conflict of ciated with LOS and time to referral (TTR), including e.g. medical
interest statement. comorbidity and psychiatric functioning. Yet, the available studies
do not account for factors that seem relevant, as time from referral
to consultation (RTC) and the effects of psychotropic medication.
E-PP0292 Our study aims at analyzing factors associated with LOS in a large
Resilience moderates severity of sample of patients, with a large set of variables and by accounting
anxiety symptoms in psoriasis for interactions.
patients Methods.– Retrospective cohort analysis of n = 3190 adult patients
E. Parlapani1 , E. Mitsiou2 , D. Kirla1 , A. Patsatsi2 , G. Floros3 , I. referred to the CL psychiatry service of a general hospital. We use
Diakogiannis1 , V. Bozikas3* descriptive and univariate statistics for a first assessment of the
1 Faculty of Medicine- Aristotle University of Thessaloniki, 1st patient cohort. Multiple regression will be performed to assess the
Department of Psychiatry, Thessaloniki, Greece; 2 Faculty of association between patient characteristics and LOS. Pathway anal-
Medicine- Aristotle University of Thessaloniki, 2nd Department of ysis will be used to elucidate the mediating role of TTR.
Dermatology and Venereology, Thessaloniki, Greece; 3 Faculty of Results.– Univariate analysis shows that TTR, age, medication side
Medicine- Aristotle University of Thessaloniki, 2nd Department of effects and poor general functioning are associated with longer LOS;
Psychiatry, Thessaloniki, Greece suicidal ideation, a diagnosis on Axis II and discharge at home are
* Corresponding author. linked to lower LOS; diagnosis on Axis I and RTC have no signifi-
cant association with LOS in our sample. Preliminary results of the
Background and aims.– Psoriasis patients show a high prevalence of multiple regression are shown in Table 1.
anxiety symptoms, associated with psoriasis-related factors, per-
ceived stigma and quality of life. Psychological contributors to
anxiety symptoms have not been extensively investigated yet. The
present study focused on resilience, in an effort to explore addi-
tional factors affecting the emergence of anxiety symptoms in
psoriasis patients.
Methods.– Fifty-eight study participants were recruited from the
Psoriasis Outpatient Clinic of the 2nd Department of Dermatol-
ogy and Venereology, Aristotle University of Thessaloniki, during
a 14-month period. Sociodemographic data, psychiatric and medi-
cal history were recorded based on a semi-structured interview and
Table 1. Multiple regression of length of stay (N = 3167)
patients’ medical records. Psoriasis severity was evaluated by the
Conclusions.– Our study will inform the debate on the role of timely
Psoriasis Area and Severity Index, the Physician Global Assessment
psychiatric consultations in the general hospital.
and the Body Surface Area. Psychometric assessment included the
Beck Anxiety Inventory (BAI) and the Resilience Scale. Participants
interest statement.
were divided into two subgroups based on the optimal BAI cut-off
score.
Results.– Psoriasis patients with more severe anxiety symptoms
displayed significantly lower resilience levels. Anxiety symptoms
E-PP0294 nition, documentation and management of pre-existing mental

Collaboration between primary care health diagnoses in patient’s being referred, including delirium.
physicians and consultation-liaison Methods.– Project plan: To evaluate the impact of a prototype of
embedded care between physical and mental health services for
psychiatrists for complex cases: a case the older person presenting via A&E: a 4 week trial in March 2018 of
report a Higher Trainee Psychiatrist (project lead) working directly within
C. Derbel* , K. Tzartzas, T.S. Goncalves Alvané, R. Marion-Veyron the TREAT MDT on a daily basis, in a model of embedded care
University of Lausanne, Department of Ambulatory Care and between mental and physical health care.
Community Medicine, Lausanne, Switzerland Results.– Results (4 weeks of data):
Number of complex delirium patients avoiding admission on new
pathway and attributable to intervention: 3
Background and aims.– Mental disorders are common in primary
Total cost savings from new admission avoidance (×3) attributable
care (25% to 60%). More than half of patients consult a primary
to project over 4 week trial: £9753
care physician (PCP) for psychiatric symptoms. Complex situations
Potential annual savings from integrated care for complex delirium:
require a close cooperation between PCPs and psychiatrists.
£117,036
Our aim is to demonstrate the role of consultation-liaison (CL)
Conclusions.– By full integration of care between community, sec-
psychiatrist in the management of polymorbid patients and
ondary care and mental health services we can achieve better
improvement of quality of care.
outcomes at lower cost for our patient group.
Methods.– Case report of Mrs. L, a 55 years separated woman.
She suffered from gastric carcinoid tumors treated with total
interest statement.
gastrectomy and oesophagectomy, with multiple postoperative
complications and chronic abdominal pains (AP). Due to these
problems, she stopped working and she is socially isolated. AP E-PP0296
worsened during the last year with an onset of anxio-depressive
symptoms (ADS), motivating multiple emergency consultations
Dimensions of personality that are
and Lorazepam introduction. correlated with the high risk of
Results.– During CL brief intervention (4 sessions), the hypotheses perinatal depression and anxiety
that AP worsening was a somatic manifestation of mental distress V.R. Enatescu1* , M. Craina2 , A. Gluhovschi2 , I. Enatescu3 , L.
linked with her separation and social isolation, was advanced. Even Hogea4 , L.A. Nussbaum5 , V. Enatescu6 , E. Bernad2
1 Victor Babes’ University of Medicine and Pharmacy Timisoara,
if AP augmentation was not explained by an organic deterioration, a
real and disabling suffering was validated and communicated to the Psychiatry, Timisoara, Romania; 2 Victor Babes’ University of
patient and the PCP. By this way, bereavement around the loss of the Medicine and Pharmacy Timisoara, Obstetrics and Gynecology,
patient’s job, her physical health and her couple was worked-out. Timisoara, Romania; 3 Victor Babes’ University of Medicine and
Anxiety symptoms were decreased and iatrogenic benzodiazepine Pharmacy Timisoara, Neonatology, Timisoara, Romania; 4 Victor
dependence was avoided. Babes’ University of Medicine and Pharmacy Timisoara, Psychology,
Conclusions.– Through our CL intervention, we made links between Timisoara, Romania; 5 Victor Babes’ University of Medicine and
the patient’s somatic and psychiatric symptoms, which were Pharmacy Timisoara, Pedopsychiatry, Timisoara, Romania; 6 West
intertwined and mutually reinforced. Better understanding of the Medica Clinic Satu Mare, Psychiatric Ambulatory, Satu Mare,
symptoms was introduced for the patient and the PCP, and thus, a Romania
treatment plan, taking into account the psychosomatic dimension,
was mutually accepted.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– Perinatal depression and anxiety are the
interest statement. most frequent psychopathological phenomena occurring in preg-
nancy and postnatal period that result in a wide array of negative
psychological and biological consequences, both in mother and
E-PP0295 infant. Personality should be considered as a possible mediating
factor for the appearance of both psychopathological conditions.
Beyond consultation-liaison
Our study aims to identify the dimensional aspects of personality
psychiatry: mental and physical that could play a predictive role in the development of anxiety and
health collaboration for admission depressive symptoms during the perinatal period.
avoidance in the emergency Methods.– Of 202 initially assessed pregnant women, 142 were
department with older adults–a agreeing to be evaluated in the second phase of a clinical prospec-
prototype model of care tive study being between 6 to 8 weeks postnatally. Personality
dimensions were measured based on five-factor model along with
J. Dove1* , S. Joels2
1 trait anxiety.
Barnet Enfield & Harringey NHS Trust, Liaison Psychiatry, London,
Results.– Interestingly, both depression and anxiety levels have
United Kingdom; 2 Camden & Islington NHS Foundation Trust, Old
decreased more than twice in the postnatal period compared
Age Psychiatry - Memory Service Camden, London, United Kingdom
* Corresponding author. to the antenatal period. Neuroticism has had a predictive value
shared by both perinatal anxiety and antenatal depression.
Background and aims.– Low level of extraversion predicted antenatal anxiety while the
Background.– Integrated care models between physical and men- high level of agreeability predicted postnatal depression. High
tal health services in the UK NHS are being asked to address their level of trait anxiety was the strongest predictor for perinatal
unwarranted variation in care outcomes in novel ways (NHS 2014, depression.
Naylor 2016). The purpose of this project is to demonstrate how an Conclusions.– Anxiety and depression have a similar pattern of
alternative model of psychiatric care in the acute hospital setting evolution during perinatal period being more pronounced in ante-
can better serve our patients. natal than in postnatal period. Distinct dimensions of personality
Aims.– To increase the impact (admission avoidance) of the Triage together with trait anxiety may be an interface and the mediating
and Rapid Elderly Assessment Team (TREAT) at the emergency factors for perinatal depression and anxiety.
department of the Royal Free Hospital London by improved recog- Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
E-PP0297 appearance changes in dermatological diseases and mental health

The antipsychotic property of conditions, e.g. depression and anxiety.
neoadjuvant chemotherapy regime Objective is to investigate an association between dissatisfaction
with cutaneous body image and depression/anxiety in dermato-
5-flourouracil, epidoxorubicin and logical diseases.
cyclophosphomide (FEC) in a patient Methods.– 100 patients with dermatological disorders: psoriasis
with treatment resistant (n = 63), localized scleroderma (n = 20), melanocytic nevi (n = 17),
schizophrenia: a case study and healthy subjects (n = 57) participated in the study. The Patient
B. Francis1* , J.S. Gill1 , A.H. Sulaiman1 , C.F. Petrus2 , O.H. Koh1 Health Questionnaire (PHQ-4) was applied as a screening tool for
1 University of Malaya, Psychological Medicine, Kuala Lumpur, depression and anxiety. The Cutaneous body image scale (CBIS)
Malaysia; 2 Hospital Raja Permaisuri Bainun, Internal Medicine, Ipoh, was used as a part of a major study of its Russian version adap-
Malaysia tation. Mann-Whitney U-Test, Kruskal–Wallis test and Spearman
* Corresponding author. correlation were applied.
Results.– Preliminary results of adaptation of CBIS showed signifi-
Background and aims.– Chemotherapy plays a pivotal role in the cant differences in all 7 scale items in comparison of dermatological
armamentarium of malignant breast cancer treatment. However, patients to healthy controls (p ≤ 0.05). Comparison between der-
little is known of their antipsychotic property. This case study aims matological diseases showed significant differences in 3 from 7 CBIS
to describe the antipsychotic property of the 5-Flourouracil, Epi- items (p ≤ 0.05) for psoriasis indicating lower satisfaction with the
doxorubicin and Cyclophosphamide (FEC) regime in a patient with overall appearance of the skin (item 1), complexion or overall color
treatment resistant schizophrenia. of the skin (item 2), and appearance of finger nails (item 6). Cor-
Methods.– A case study describing the marked improvement relation analysis showed a negative relation (r = −0.247, p = 0.01)
of psychotic symptoms in a patient with treatment resistant of satisfaction with cutaneous body image and PHQ depression
schizophrenia upon initiation of the FEC regime is presented. severity and no significant relation of scores in CBIS and anxiety.
Results.– A 47 year old lady diagnosed with chronic schizophrenia Conclusions.– Dissatisfaction with cutaneous body image is related
for the past 25 years failed to respond to adequate dosages of several to depression (but not to anxiety) and could have a distinguish-
atypical antipsychotics such as risperidone, olanzapine, and queti- ing ability in the research of mental state of patients in different
apine. Eventually she showed partial response to clozapine at the dermatologic diseases.
dose of 450 mg/day, however clozapine could not be titrated further Disclosure of interest.– The authors have not supplied a conflict of
due to severe hypotension. She was diagnosed with adenocarci- interest statement.
noma of the left breast a few months after clozapine was initiated.
After a thorough workup, she was commenced on the neoadjuvant
FEC regime and planned for 6 cycles to shrink the tumour prior E-PP0299
to operation. At this time, she was maintained on oral clozapine Creutzfeldt-Jakob disease hidden by a
450 mg/day and still had psychotic symptoms such as persecutory traumatic brain injury, a case report
delusions and loosening of association. After the fifth cycle, she had A.M. Gomez Alzate1* , S. Gomes da Costa2 , L.M. Paramo Duque3
markedly improved positive and negative symptoms and did not 1 Universidad de Antioquia, Psychiatry, Medellín, Colombia; 2
have loosening of association. Hospital Clinic, Psychiatry- Clinical Institute of Neuroscience,
Conclusions.– This case illustrates the antipsychotic property of the Barcelona, Spain; 3 Hospital Universitario San Vicente Fundacion,
FEC regime used in a patient with treatment resistant schizophre- Liaison Psychiatry, Medellin, Colombia
nia. The antipsychotic property of the FEC regime could be by * Corresponding author.
virtue of its dopaminergic modulation at the basal ganglia, affecting
salience perception. Background and aims.– Creutzfeldt–Jakob disease (CJD) is a rare
Disclosure of interest.– The authors have not supplied a conflict of neurodegenerative and rapidly progressive condition, occurring in
interest statement. 1 to 1.5 per million population worldwide. There are 3 forms, of
which the sporadic form is the most common. It presents typi-
cally at around 60 years of age with cognitive decline, ataxia, and
E-PP0298 myoclonus. This is a case report of a patient who initially presented
Dissatisfaction with cutaneous body with changes in personality after a mild traumatic brain injury (TBI)
image and depression/anxiety in and was finally diagnosed with CJD.
Methods.– A 57-year-old male was brought by his family one month
dermatological diseases: preliminary
after a mild TBI. He had been experiencing changes in personality,
results mood, language, and motor behavior. Blood chemistry and neu-
A. Malyutina1 , M. Vinogradova2 , V. Golimbet3* , A. Lvov4 , D. roimaging were interpreted as normal. Over the next three months
Romanov5 he progressively deteriorated with impossibility to walk, to control
1 Lomonosov Moscow State University, Department of Neuro- and
sphincter and to talk. A second MRI evidenced areas of hyperin-
Pathopsychology, Moscow, Russia; 2 Lomonosov Moscow State tensity and restriction of cortical and basal ganglia diffusion in T2,
University, Department of Neuro- and Pathopsychology- Faculty of considered as MRI definitely CJD.
Psychology, Moscow, Russia; 3 Mental Health Research Center, Results.– Despite the increasing incidence over the last decades,
Clinical Genetics Laboratory, Moscow, Russia; 4 Moscow Scientific CJD is still rare, for which it is not usually considered as part of
and Practical Center for Dermatovenerology and Cosmetology, the differential diagnosis. In this patient, TBI acted as a confounder
Department of Clinical Dermatovenerology and Venerology, Moscow, factor and delayed appropriate diagnosis and management. MRI
Russia; 5 I.M. Sechenov First Moscow State Medical University played a crucial role in this patient’s diagnosis process, as it was
Sechenov University, Department of Psychiatry and Psychosomatics, impossible to obtain samples for a neuropathologic diagnosis.
Moscow, Russia Conclusions.– A high level of suspicion is required to diagnose CJD.
In patients with a rapid clinical decline, other clinical information
Background and aims.– Dissatisfaction with cutaneous body image, (such as TBI) may act as a confounder.
reflecting distortion in individuals’ perception of the skin, hair Disclosure of interest.– The authors have not supplied a conflict of
and nails, could be a helpful psychological construct mediating interest statement.
E-PP0300 Conclusions.– The presence of transient, acute or chronic mental

Severe suicide attempts in disorders during the medical illness impact on the evolution and
consultation-liaison: what can we therapeutic adherence, as well as on the quality of life of the patient.
learn? interest statement.
F.J. Gomez Beteta* , M. Villanueva Gallego, D. Gimeno Alvarez
Instituto de Psiquiatria y Salud Mental del Hospital Clinico San
Carlos, Psychiatry, Madrid, Spain E-PP0302
A cross-sectional study of depression
Background and aims.– Most of people who die by suicide have and quality of life in chronic kidney
psychiatric disorders, notably mood, substance-related, anxiety, disease patients undergoing
psychotic and personality disorder. Another risk factor associated haemodialysis
to suicide is drug consume. The most common methods of suicide S. Joseph John1* , S.S. Bhandari2 , S. Dutta2 , D. Khatri3
world wide are pesticide poisoning, hanging and fire guns. Our aim 1 Dr. Shijo JJ- Senior Resident and Faculty- Sikkim Manipal Institute
is to study and describe sociodemographic and clinical character- of Medical Sciences, Psychiatry, GANGTOK, India; 2 Sikkim Manipal
istic of people who has committed a suicide attempt and has been Institute of Medical Sciences, Psychiatry, Gangtok, India; 3 Sikkim
recovered in a medical room due to severe physical consequences. Manipal Institute of Medical Sciences, Internal Medicine, Gangtok,
Methods.– We checked the clinical histories of recovered patients India
in a medical service because of suicide attempt, who required * Corresponding author.
consultation-liaison psychiatry intervention from January 2016 to
December 2017. We obtained a sample of 52 patients and we regis- Background and aims.–
tered sociodemographic data, method of suicide attempt, diagnosis Introduction.– Patients with Chronic Kidney Disease (CKD) who
and drug abuse. receive hemodialysis are vulnerable to emotional problems due to
Results.– We found that the most common method was overdosing chronic stress associated functional restrictions, accompanying ill-
(75%), followed for precipitation (19%) and self-cutting. About 46% ness, and adversities of treatment. There is a scarcity of literature
of patients has used any drug (alcohol, stimulants) when they did with this regard in developing and low income countries like India.
the attempt. The diagnosis were major afective disorder (31%), per- Objectives.– To assess depression and Quality of Life (QoL) in CKD
sonality disorder (31%), adjustment disorder (27%) and psychosis patients undergoing haemodialysis and its impact of depression on
(5,5%). The left 5,5% didn’t have psychopathology alteration when their QoL.
they attempted suicide. Methods.– Patients were assessed from two dialysis centres in
Conclusions.– We found that overdose is the main method of sui- Sikkim state of India. Patient Health Questionnaire-9 (PHQ-9),
cide with severe psychical consequences, followed by precipitation. World Health Organization Quality of Life-BREF (WHOQOL-BREF)
Drug abuse is frequently associated with suicide attempt. and Charlson Comorbidity Index (CCI) scales were used. Sociode-
Disclosure of interest.– The authors have not supplied a conflict of mographic and clinical variables were described using mean and SD
interest statement. for continuous variables, while categorical variables using percent-
ages. c2 test, Kruskal-Wallis, Man Whitney, Spearman’s rho tests
were used for statistical analysis with the aid of SPSS version 20.
E-PP0301 Results.– The mean age of the participants was 49.21 (SD = 13.371).
We need help The number of males was higher (58.6%) than females (41.4%). A
M.J. Gordillo Montaño* , S.V. Boned Torres, I. Moreno Encabo, M. sizable number of participants (45.9%) were unemployed individ-
Amuedo Rincon, J. Iglesias Lopez, L. Torres Guasch, S. Latorre uals. The duration of dialysis had a mean of 16.00 (SD = 12.781)
Hospital Can Misses, Psychiatry, Eivissa, Spain (in months). The prevalence of depression was found to be
* Corresponding author. 36.04%. QoL had mean scores of 11.1609 (SD = 2.61954) for physi-
cal health, 13.3682 (SD = 2.54318) for psychological health, 16.0360
Background and aims.– The liaison Psychiatry or consultative psy- (SD = 2.77192) for social relationships and 14.3919 (SD = 1.65887)
chiatry focuses its clinical interest in the interaction or meeting for environment. Depression was found to significantly impact all
between psychiatry and other medicine specialties. Among the domains of QoL negatively. (p-value = 0.000, with all domains of
medical specialties, the assessment by consultative psychiatry of QoL)
the psychosocial repercussions of the disease in the hospitalized Conclusions.– This study concluded that depression is prevalent in
patient is increasing its recognition. CKD patients undergoing haemodialysis and it adversely impacts
Objective.– Current health care requires holistic and comprehensive QoL in all domains.
treatment of the hospitalized patient, considering that the man- Disclosure of interest.– The authors have not supplied a conflict of
agement and treatment of some diseases can affect the mental and interest statement.
emotional state of the person in addition to requiring cooperation
between different medical specialties. Involvement of the patient
and his family in stabilizing the disease is also required. E-PP0303
Methods.– We analyse the queries requested and attended during Physicians’ perceptions and
a whole year distinguishing the service that requested it and the
reason why they did it.
experiences on functional
Results.– The affective syndromes, and among them the depressive neurological symptom disorder: the
syndromes, are the most frequent reasons for the consultation to negative emotions aspect
the psychiatry service. Somatization, complex in its management, O. Kilic1* , H. Yapici-Eser2 , C. Aktas3 , I. Necef4 , U. Altunoz5 , O.
occupies another place of interest. Another important reason was Oztop-Cakmak6
1 Koç University Hospital, Psychiatry, Istanbul, Turkey; 2 Koç
the intoxication, dependence or deprivation to alcohol or other
substances. Low number of hematology and oncology consulta- University School of Medicine, Department of Psychiatry, Istanbul,
tions, due to their own specific programs. Most of the consultations Turkey; 3 Koç University School of Medicine, Department of
requested by medically ill psychiatric patients for pharmacological Emergency Medicine, Istanbul, Turkey; 4 Koç University Hospital,
adjustment were in patients already diagnosed and even with good Department of Psychiatry, Istanbul, Turkey; 5 Wahrendorff Clinic,
therapeutic adherence. Department of Transcultural Psychiatry & Psychotherapy, Hannover,
Germany; 6 Koç University Hospital, Department of Neurology, frequent was Adjustment Disorder. About a quarter (16,67%,) of the
Istanbul, Turkey clinical presentations were directly related to work and burn-out.
* Corresponding author. After the consultation, 51,5% were considered fully apt and 44,6%
conditionally apt. We found that 10% of the professionals have been
Background and aims.– Background and aims: Our understanding under limited functions due to psychiatric disease despite not hav-
of the management of functional neurological symptom disorder ing mental pathology that interfere with working capacity.
(FNSD) (conversion disorder) has improved significantly over the Conclusions.– The prevalence of psychiatric diseases which are not
past decade, however, it is unlikely to improve the care. We aim to associated with chronic impairment and the significant percentage
explore physicians’ experiences and perceptions related to FNSD of release from consultancy determine that this program of psychi-
that might provide important insight into this treatment gap. atric consulting can be an asset in occupational mental health and
Methods.– A structural, cross-sectional survey was distributed in the reduction of sick leave.
online to emergency medicine specialists’, internists’, and psychia- Disclosure of interest.– The authors have not supplied a conflict of
trists. The survey included questions on general knowledge related interest statement.
with FNSD, physician’s own emotional and behavioral reactions
towards FNSD patients and their management strategies.
Results.– 557 physicians filled in the questionnaire. Approximately E-PP0305
three-fourths were visited by patients with FNSD either every day Using research domain criteria over
or at least 2–3 times each week. Three-fourths of the physicians
dsm and ICD as a means of simplifying
felt negative emotions towards these patients. Nevertheless, three-
fourths of the physicians perceived themselves well-equipped to the teaching of general practitioner
treat them. Age, gender, being a trainee or a specialist and spe- trainees how to prescribe psychiatric
cialty type do not affect physicians’ negative emotions. Knowledge medications
of the seizure-like presentation of conversion disorder increases L. Mehl-Madrona1 , B. Mainguy2* , P. McFarlane3
the likelihood of positive emotions (p = 0.017) towards patients. 1 University of Maine, Graduate School, Orono- Maine, USA; 2
Conclusions.– Physicians’ negative emotions could be explained University of Maine at Orono, School of Social Work, Orono, USA; 3
by inadequate training programs on the assessment and manage- University of New England - Bangor Campus, Family Medicine,
ment of functional neurological symptom disorder. An elaborative Bangor, USA
education of physicians on the practical aspects of treatment and * Corresponding author.
preparing guidelines can help to overcome negative emotions

towards those patients. Background and aims.– In North America, the majority of psychi-
Disclosure of interest.– The authors have not supplied a conflict of atric prescribing is done by general practitioners, especially in rural
interest statement. areas. The DIagnostic and Statistical Manual of the American Psy-
chiatric Association and the International Classification of Diseases
are only growing in number of diagnoses and can be quite confusing
E-PP0304 to general practice trainees. We wondered if a simplified method of
Psychiatry consultation in the teaching psychiatric prescribing based upon brain circuitry would
be easier for these trainees to understand and learn and still allow
occupational health service - 3 years
them to make appropriate prescriptions.
of experience in centro hospitalar de Methods.– We reconceptualized psychiatric symptoms in terms
São João, Porto, Portugal of disturbances in brain function. We generated five basic areas:
A.S. Machado1* , R. Grangeia1 , P. Norton2 (1) hopelessness and helplessness, (2) anxiety, fear, and worry,
1 Centro Hospitalar Universitário de São João, Clínica de Psiquiatria e (3) disturbances in perception, processing, and interpretation of
Saúde Mental, Porto, Portugal; 2 Centro Hospitalar Universitário de the world, (4) disturbances in goal setting, pursuit of goals, pur-
São João, Serviço de Saúde Ocupacional, Porto, Portugal suit of rewards, (5) disturbances in salience, (6) disturbances in
attention, (7) disturbances in central executive functioning. Within
each of these seven areas, we linked brain circuits and developed
Background and aims.– The effects of mental disorder on the
a rationale for drug selection. For example, for #1, the antide-
working population are an increasing problem worldwide. The
pressants; #2, antidepressants, buspirone, benzodiazepines, and
Occupational Health Service collaborated with the Psychiatry and
certain anticonvulsants; #3, antipsychotics; #4, antipsychotics,
Mental Health Clinic of Centro Hospitalar de São João creating a pro-
anticonvulsants; #5, antipsychotics for down regulation; agents
tocol of psychiatric consultation in April 2015 in order to make a
that increase dopamine and norepinephrine for up-regulation; #6,
better evaluation of working impairment caused by mental pathol-
stimulants and agents that increase dopamine and norepinephrine;
ogy.
#7, antipsychotics.
We aim to examine the effectiveness in terms of organizational and
Results.– General practice trainees were more able to understand
clinical outcomes of three years of protocol of psychiatric consul-
this simplified approach which was more grounded in brain func-
tation in the OHS.
tion and contemporary neuroscience than the taxonomy approach
Methods.– A retrospective study regarding psychiatric consultation
of DSM or ICD. They felt more comfortable with psychiatric pre-
in the OHS of CHSJ from April 2015 to April 2018 was carried out.
scribing.
Data were analyzed with SPSS (V 24.00) using descriptive statistics.
Conclusions.– Our reconceptualization made learning and prescrib-
Results.– During this period 100 patients were evaluated. The typol-
ing psychiatric medications easier for general practice trainees.
ogy of the patient evaluated is female, health care assistant or nurse,
which has been referred due to exemption from night work. Psy-
interest statement.
chiatric diagnoses were established in 71% of the patients, the most
E-Poster Presentation: Consultation Liaison Background and aims.–

Psychiatry and Psychosomatics - Part II Introduction.– Chronic obstructive pulmonary disease (COPD) asso-
ciated with wide range of psychiatric disorders and symptoms.
Among them a special place occupied by psychopathological reac-
tions to disease, which impair quality of life, pulmonological
E-PP0306 compliance and course of COPD. Objectives of the study–identify
Motivational conflicts, coping and validate types of psychopathological reactions to disease in
strategies and ego defense patients with COPD, in order to determine therapeutic strategies
mechanisms in middle-age patients and conduct rehabilitation programs.
Methods.– Sample n = 138 outpatients with COPD (34 female). Mean
with essential hypertension: the
age 65 (st. dev 9.4). Single-center observational study. Dependent
network analysis variable–type of psychopathological reaction to disease (clinical
E. Pervichko* , Y. Babaev, Y. Zinchenko psychopathological method was used). Independen variables: age,
Lomonosov Moscow State University, Faculty of Psychology-, number of smoke cessation attempts, pulmonological therapy com-
Moscow, Russia pliance, hemoglobin oxygen saturation (Sat O2), depression and
anxiety level (HARS, HDRS), emotion regulation strategies (CERQ).
Background and aims.– Many studies show that patients with essen- Ordered logit model was used for statistical analysis.
tial hypertension (EH) demonstrate certain patterns of motivation, Results.– Four types of psychopathological reactions to COPD dis-
coping strategies, ego defense mechanisms, and personality traits. ease were defined (via clinical psychopathological method): 1.
Network analysis could help to discover and visualize them. Normal, 2. Depressive 3. With anxiety about health 4. With
The purpose of this study was to examine the interconnection of poor insight. Statistical analysis allowed to build a model, which
psychological variables in EH patients (motivation, coping strate- describes connections between 9 independent variables with above
gies, ego defenses), compared to healthy individuals, using the mentioned psychopathological 4 types reactions. pci = 1/(1 + exp
network approach. (−␣c + Si)), S = 0.07. Age + 1.40. Number of smoke cessation
Methods.– Network analysis (Bomsbroom, 2013), 16PF Question- attempts −2.13 Treatment + 0.24 SatO2 −0.26 HARS + 0.71 HDRS
naire (Cattell, Mead, 2008), TAT by H. Heckhausen, Multi-Motive −0.19 Rumination [CERQ] −0.20 Positive thinking [CERQ] −0.30
Grid (Sokolowski et al., 2000), Life Style Index (Plutchik, Keller- Other blame [CERQ].
man, Conte, 1979), The Ways of Coping Questionnaire (Folkman, Conclusions.– Defined 4 types of psychopathological reactions to
Lazarus, 1988), Cognitive Emotion Regulation Questionnaire (Gar- COPD disease were validated with ordered logit statistical analysis.
nefski, Kraaij, Spinhoven, 2001), The Stroop Color and Word Test Each type suppose personalized and differential approach to treat-
(Stroop, 1935), Hamilton Depression and Anxiety Rating Scales. ment (psychopharmacotherapy and psychotherapy) of patients
The study involved 83 naive middle-age EH patients with uncom- with COPD.
plicated EAH, stage 1–2, average age is 51.1 ± 6.78, and 70 Disclosure of interest.– The authors have not supplied a conflict of
normotensive persons, average age is 47,9 ± 6,6. interest statement.
Results.–
1. Patients with EH demonstrate strong correlations between dif-
E-PP0308
ferent psychological variables compared to healthy individuals.
This may reflect more rigid patterns of psychological functioning. Quality of life and psychological
2. There are certain clusters of variables which form “small worlds” distress in patients with dilated
in terms of network approach in HE patients, for example cardiomyopathy
self-blame coping strategy, positive thinking, achievement moti- S. Sallam1* , K. Aly2
vation, vigilance and privateness. 1 Faculty of Medicine- Ain Shams University, Psychiatry, Cairo, Egypt;
3. Depression and anxiety levels are connected to some psycholog- 2 Faculty of medicine- Ain Shams University, Cardiology, Cairo, Egypt
ical variables in HE patients and have no significant connections * Corresponding author.
in healthy group.
Conclusions.– Network approach helps broaden our vision of the Background and aims.– Cardiovascular diseases are the leading
psychological correlations of essential hypertension, the results cause of death globally. [1] They also cause severe problems in
open up perspectives for further studies on this topic. psychological and social aspects [2].
The research was supported by RFBR; project № 17-06-00954. Those with dilated cardiomyopathy (DCM) have substantial limi-
Disclosure of interest.– The authors have not supplied a conflict of tations in daily activities; moreover the poor prognosis may result
interest statement. in emotional distress among patients and their families [3].
Objectives.– To measure quality of life and psychological state in
patients with dilated cardiomyopathy using standardized mea-
E-PP0307 sures.
Psychopathological reactions of Methods.– This is an observational cross sectional study. A hundred
patients with DCM without previous history of psychiatric disor-
patients to chronic obstructive
der were included and compared to hundred healthy controls. They
pulmonary disease (clinical analysis underwent physical examination, echocardiography. Quality of life
and mathematic modeling) was assessed using the short form 36 health survey (SF-36). Anx-
S. Ovcharenko1,2 , B. Volel1,2 , Y. Galetskayte1,2 , I. Pluzhnikov3* , A. iety and depression were assessed with the hospital anxiety and
Simonov1 , S. Khrushchev4,5 depression (HAD) scale.
1 The Mental Health Research Center MHRC, The Mental Health
Results.– Patients with DCM had a worse quality of life with lower
Research Center MHRC, Moscow, Russia; 2 Sechenov First Moscow mean SF-36 score (47.9 ± 10.59) compared to the control group
State Medical University, Sechenov University, Moscow, Russia; 3 The (69.9 ± 8.1). They also had worse HAD scale (35.2 ± 18.73) com-
Mental Health Research Center MHRC, Department of Young Adult pared to the control group (17.3 ± 15.3) SF-36 score had strong
Psychiatry, Moscow, Russia; 4 National Research Center for positive correlation with left ventricular systolic function measured
Hematology, Moscow, Russia; 5 Lomonosov Moscow State University, by ejection fraction (LVEF) with (r: 0.777, R2 : 60.3%, p < 0.001) While
Psychology Department, Moscow, Russia HAD scale had a strong negative one with (r: −0.734, R2 : 53.9%,
p < 0.001).
Conclusions.– Patients with DCM have a worse quality of life as well patients are not identified in this setting. The objective of this inves-
as psychological distress (anxiety and depression symptoms) com- tigation is to describe the clinical features of a sample of medically
pared to healthy control with standardized references of 69.9 ± 8.1 ill inpatients with comorbid MDD attended by a general hospital
and 17.3 ± 15. 3 for SF-36 and HAD scale respectively. Patients with consultation-liaison psychiatry (CLP) service.
lower LVEF are at higher risk. Methods.– Descriptive study assessing adult inpatients who met
Disclosure of interest.– The authors have not supplied a conflict of DSM-IV-TR diagnostic criteria for MDD admitted to non-psychiatric
interest statement. units of the University Clinical Hospital of Barcelona (Spain) and
who were referred to our CLP service between 2005 and 2015.
Results.– During that period, 10287 psychiatric consultations were
E-PP0309 received, 559 of them (5.4%) concerned patients with MDD. These
The prevalence and correlates of patients were aged 61.4 ± 16 years and 58% were female. Figure
autism spectrum disorder in children 1 shows the referral sources according to specialty departments.
with epilepsy The most frequent reasons for referral to CLP were the assessment
M. Salma1* , L. Cherif1 , L. Sfaihi2 , K. Khmekhem1 , J. Boudabous1 , I. of depressive symptoms (52.5%) and suicidal risk/attempt eval-
Hadjkacem1 , H. Ayèdi1 , T. Kamoun2 , Y. Moalla1 uation (14.2%). In respect to CLP intervention, 95.4% of patients
1 University Hospital Hedi Chaker, Department of Child Psychiatry, with MDD received a psychopharmacological prescription and 73%
Sfax, Tunisia; 2 University Hospital Hedi Chaker, Department of required 2 or more psychiatric visits. The mean length of the hospi-
Pediatrics, Sfax, Tunisia tal for patients with MDD (20.4 ± 16.5 days) was significantly longer
* Corresponding author. (p < 0.001) than that of all the general admissions (6.8 ± 11.2 days).
Background and aims.– The present study aimed to assess the

prevalence and risk factors for autism spectrum disorder (ASD) in
epilepsy, and to better understand the relationship and comorbid-
ity between these disorders.
Methods.– The study included 130 patients with epilepsy followed-
up at Pediatric department. Autism screening was performed using
the Child Behavior Checklist (CBCL) for children aged from 2 to 5
years and the Social Communication Questionnaire (SCQ) for chil-
dren aged more than 5 years. Autism spectrum disorders diagnoses
were made with respect to Diagnostic and Statistical Manual crite-
ria.
Results.– The CBCL showed that 7.8% of our population aged from 2
to 5 years presents a significant risk of autism spectrum disorders,
also the SCQ showed that 10.1% of our population aged more than
5 years presents the same risk. Of these, only 18 children (14%)
had established ASD diagnoses. Autism spectrum disorders were
significantly correlated to the early onset of epilepsy (p = 0.008)
Figure 1. referral sources according to specialty departments.
and the specific epilepsy syndromes (infantile spasms and Dravet
syndrome) (p = 0.04). Conclusions.– The impact of comorbid MDD on hospital stays and
Conclusions.– Given the high rate of ASD comorbidity in childhood utilization of healthcare resources highlights the important role
epilepsy and noted under recognition, forming a clinical profile of of consultant psychiatrist to improve the management of these
a patient with epilepsy who is at risk for ASD, may allow for ear- patients.
lier diagnosis and intervention. Much further research is needed Disclosure of interest.– The authors have not supplied a conflict of
to define the relationship and directionality between epilepsy and interest statement.
ASD.
interest statement. E-PP0311
Exenatide worsens depression and
E-PP0310
causes suicidal ideation relapse: a case
Consultation-liaison psychiatry report
A. Şeker
intervention in a sample of inpatients Erciyes University Hospital, Child and Adolescent Psychiatry, Kayseri,
with major depressive disorder Turkey
R. Sánchez-González1* , E. Monteagudo-Gimeno1 , A.
Rodríguez-Urrutia2 , S. Herranz-Villanueva3 , L. Pintor-Pérez3 Background and aims.–
1 Institut de Neuropsiquiatria i Addiccions - Centre Emili Mira, Introduction.– Exenatide is a glucagon-like peptide-1 receptor ago-
Department of Psychiatry, Santa Coloma de Gramenet, Spain; 2 nist, belonging to incretin mimetics, approved for use in Type-2
University Hospital Vall d’Hebron, Consultation-Liaison Psychiatry Diabetes. It is not a known depressogenic drug, although there is a
Unit. Department of Psychiatry, Barcelona, Spain; 3 Institut de case report of Exenatide induced depression in a geriatric patient.
Neurociències. Hospital Clínic i Provincial de Barcelona, Objective.– To strike attention to a not well recognized side effect
Consultation-Liaison Service, Department of Psychiatry, Barcelona, of Exenatide.
Spain Methods.– Literature review in scientific database and case report
* Corresponding author. presentation.
Results.– A 14-year-old boy who had a history of type 2 diabetes,
Background and aims.– Major Depressive Disorders (MDD) are over- admitted with severe depressive complaints and recurrent suici-
represented among patients admitted to nonpsychiatric units of dal ideations. He was clinically depressed, scored 34 on Children’s
general hospitals (Rentsch et al., 2007). Although it is associated Depression Inventory (CDI) and started on Sertraline 50–100 mg
with increased healthcare costs, longer hospital stays and higher and Supportive Therapy. After 3 months of treatment, his CDI
functional disability (Egede, 2007), the majority of depressed
dropped to 15 and he was also subjectively feeling better. At that Background and aims.– Mental health services are not well-
stage, he was started on Exenatide 5 mcg/day for his Diabetes. After established in Pakistan and emergency room (ER) physicians are
the dose increase to 10 mcg/day, he started feeling significantly not well trained in dealing with psychiatric emergencies, lead-
more depressed and irritable, and his suicidal thoughts relapsed. ing to misdiagnosis and mismanagement. Since its inception more
His CDI was back to 32. He was added Aripiprazole 5 mg with no than 30 years ago, AKUH has been providing 24-hours consulta-
effect. He was hospitalized twice, both for glucose regulation and tion service for patients referred from emergency department with
depressive symptoms. Setraline was changed to Fluoxetine with no psychiatric problems. The on-call psychiatric team, comprising of a
difference. After a total of 4 months, his Exenatide was stopped and resident and a consultant, takes referrals from the ER. The depart-
his mood responded almost immediately. As he was feeling better, ment maintains a database for all such referrals.
Aripiprazole was cut off and he continued with 20 mg Fluoxetine. Methods.– Although database dates back to almost 20 years, we
His CDI was now 17. are presenting data of referrals from August 2017 to July 2018.
Conclusions.– It’s important to have a holistic look at patients, and This includes information on socio-demographic details, reason for
keep in mind that other treatments may affect the psychic state to referral, assessment, management, and outcome of referral. Data
various extents. was entered and analyzed using SPSS version 19.0.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Number of consults to psychiatric services has increased
interest statement. gradually over the years. There were more females than males. Most
patients were in the age range 21–30 years. The most common
reason for referral was self-harm followed by agitation/aggression.
E-PP0312 The most common psychiatric diagnosis was mood disorders and
Utility of structured inventory of majority of patients advised admission to psychiatric unit.
malingered symptomatology in a Conclusions.– Psychiatric emergencies are challenging and require
urgent assessment and management to stabilize the patient. Due to
sample of patients with chronic pain
lack of well-established mental health services, physicians in ER are
A. Serrano García1* , C.M. Franch Pato2 , R. Gómez Martínez2 , C.
first point of contact and need training in assessing and managing
Martínez Martínez2 , I. González Rodríguez2 , P. García Vázquez2 , S.
patients with psychiatric problems.
Núñez Sevillano2 , C. Manso Bazús3
1 Complejo Asistencial Universitario de León. Universidad de León, Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
Psychiatry, León, Spain; 2 Complejo Asistencial Universitario de León,
Psychiatry, León, Spain; 3 Corporaciò Sanitaria Parc Taulí, Psychiatry,
Sabadell, Spain
E-PP0314
Guanfacine extended release for the
Background and aims.– Pain, due to its subjective nature, is a usual reduction of aggression and self
place of simulation behaviour, however the research done in this injurious behavior in Prader-Willi
field to develop or adapt tools that allow its detection is scarce. To
syndrome–a case series
arrive to the simulation diagnosis is necessary a multidisciplinary
D. Singh1* , Y. Wakimoto2 , A. Pinkhasov1 , M. Angulo3
approach and an exquisite rigor in the application of available sci- 1 NYU Winthrop Hospital, Behavioral Health, Mineola, USA; 2 SUNY
entific evidence.
Stony Brook School of Medicine, School of Medicine, Mineola, USA; 3
Objectives.– To evaluate the usefulness of the Structured Inventory
NYU Winthrop Hospital, Endocrinology and Genetics, Mineola, USA
of Malingered Symptomatology (SIMS) in the clinical context of a * Corresponding author.
pain clinic.
Methods.– All patients were evaluated in a multidisciplinary way Background and aims.– Prader–Willi Syndrome (PWS) commonly
by an anaesthesiologist, a psychiatrist and a rehabilitator. Those presents with behavioral disturbances such as aggression, impul-
who presented medically unexplained pain were referred to psy- sivity, and self-injurious behavior like skin-picking. However, there
chiatry for individual assessment and were given to complete the are currently no well-established psychotropic medication options
SIMS. Statistical analysis was performed using COR curves of the for PWS patients. The goal of this study is to demonstrate the role of
psychometric values obtained. Guanfacine Extended Release (GXR) in the management of behav-
Results.– 288 patients with medically unexplained pain were ioral disturbances seen in PWS patients.
assessed, 78 cases of symptom simulation were detected as the Methods.– In this retrospective case series, charts of PWS patients
most probable diagnosis after the psychiatric interview. The values at a single clinical site over a 4-year period who presented
obtained for sensitivity and specificity for the SIMS tool were 0.910 with aggression/agitation, skin-picking, and/or symptoms of atten-
and 0.757 respectively. No subscale exceeded the overall sensitiv- tion deficit/hyperactivity disorder (ADHD), and treated with
ity score but the subscales of Psychosis and Amnesic Disorders had GXR were reviewed. Clinical response to GXR were categorized
a very high specificity (0.957 and 0.910, respectively). as improved, worsened, or unchanged, and side-effects were
Conclusions.– The psychometric properties of the spanish version analyzed.
of the SIMS allow its use in the clinical context of a pain clinic and Results.– Twenty PWS patients with behavioral disturbances
it supports the clinical diagnosis. treated with GXR were identified. Eleven patients reported skin-
Disclosure of interest.– The authors have not supplied a conflict of picking, 17 reported aggression/agitation, and 16 reported ADHD
interest statement. symptoms. Improvement in symptoms were observed with GXR
treatment in 9 (81.8%) of the patients with skin-picking, 14 (82.3%)
with aggression/agitation, and 15 (93.7%) with ADHD symptoms.
E-PP0313 Two patients with prior history of psychosis (auditory hallucina-
Psychiatric emergencies in low & tion and delusions) did not respond to GXR. No weight gain was
middle income countries: experiences observed in patients treated with GXR.
at AGA Khan University Hospital Conclusions.– GXR demonstrated improvement in symptoms of
skin-picking, aggression/agitation, and ADHD in patients with PWS.
(AKUH), Karachi
No efficacy of GXR in treatment of psychotic symptoms was demon-
S.A. Siddiqui, H. Saeed
strated. More studies are warranted to further establish the utility
Aga Khan Univeristy, Psychiatry, Karachi, Pakistan
* Corresponding author. of GXR in patients with PWS.
Disclosure of interest.– The authors have not supplied a conflict of burden than cognitive/affective and would be more strongly asso-
interest statement. ciated with all-cause mortality post-implantation.
Methods.– In this retrospective study, pre-operative PHQ-9 scores
were utilized to evaluate somatic and cognitive/affective symp-
E-PP0315 toms in patients who underwent LVAD placement from 2007–2017.
Liaison psychiatry in a portuguese Demographic variables, mean PHQ-9 scores, and proportions of
general hospital: improving delirium patients with PHQ-9 scores ≥10 were compared in both groups. An
analysis of the effect of PHQ-9 total, somatic, and cognitive/affective
recognition among junior doctors
scores on all-cause mortality was completed using Cox Proportional
L. Sousa* , I. Carvalho, E. Mendes, L. Ribeiro
Hazards Model.
Centro Hospitalar de Vila Nova de Gaia/Espinho, Psychiatry and
Results.– Total PHQ-9 scores did not differ between groups, but
Mental Health, Vila Nova de Gaia, Portugal
* Corresponding author. there was a trend toward more DT patients with PHQ-9 scores
≥10. Somatic symptoms accounted for three-quarters of total PHQ-
Background and aims.– Despite the increase in research on delirium 9 scores in both groups. In Cox Proportional Hazards Models, PHQ-9
it remains underdiagnosed and difficult to manage. Liasion psychi- total, somatic and cognitive/affective symptoms were not associ-
atry is in a special position to help improve the management of ated with all-cause mortality.
this syndrome and junior doctors are an important population to Conclusions.– The mean severity of depressive symptoms and the
be targeted. proportion of patients with clinically significant depression did
We aim at exploring the understanding of junior doctors about not differ between groups. Mean depressive symptoms were mild,
Delirium, their ability to diagnose and treat this condition and to with a preponderance of somatic symptoms. Pre-implantation
investigate patterns of referral to liaison psychiatry. depressive symptoms were not associated with post-implantation
Methods.– Retrospective study of cases referred to liaison psychia- mortality. Additional work is needed to identify depression better
try during a 6-month period in a general hospital. Conduction of in this population and to measure its unique effects on their clinical
face-to-face Interviews with junior doctors and application of a course and well-being.
pre-defined questionnaire. Disclosure of interest.– The authors have not supplied a conflict of
Results.– During the study period 157 cases have been referred to interest statement.
liaison psychiatry; 95 were delirium cases and of those 67% were
misdiagnosed as a psychiatric illness. 78% of the junior doctors
in the hospital have answered a questionnaire regarding delirium E-PP0317
identification and management; less than half correctly identified Early identification of psychological
clinical characteristics of delirium; only 60% reported doing rou- problems in young people with
tine examinations of mental state; around 50% identified delirium long-term physical conditions
as having an organic etiology; different types of delirium were H. Thabrew
correctly identified by around a third; active search of organic University of Auckland, Psychological Medicine, Auckland, New
pathology before psychotropic administration was reported by Zealand
55%; almost 80% assume they will ask liaison psychiatry consul-
tation in first place; almost 90% expressed the opinion that their Background and aims.– Children and adolescents with long-term
knowledge about delirium diagnosis and management is not ade- physical conditions are at greater risk of developing psychological
quate. problems, particularly anxiety and depression. In some countries,
Conclusions.– Delirium is often misdiagnosed as a psychiatric screening for these problems is undertaken in certain sub-groups
syndrome and psychiatry consultation is frequently requested. (e.g. young people with cystic fibrosis) using individual screening
However, when identified, workup and pharmacological manage- instruments. The administration and scoring of these instruments
ment seems appropriate. Junior doctors expressed a need for more can be costly and/or time-consuming and screening for multiple
information on delirium. problems is rarely undertaken due to the lack of validated compos-
Disclosure of interest.– The authors have not supplied a conflict of ite screeners.
interest statement. Methods.– An composite electronic psychosocial screener called
“YouthCHAT” has recently been developed in New Zealand and
been shown to be effective for identifying adolescent anxiety,
E-PP0316 depression, substance abuse and other psychosocial problems.
Cognitive/affective and somatic The acceptability and feasibility of using YouthCHAT to identify
aspects of depression prior to LVAD psychosocial problems in young people with different long-term
physical conditions was evaluated over a 2 month period with 30
implantation and associations with
young people attending a paediatric outpatient clinic in Auckland,
mortality New Zealand.
L. Suarez Pardo1* , S. Schettle D2 , J. Stulak M.2 , J. Staab P.1 , S. Results.– YouthCHAT was found to be acceptable to both young peo-
Dunlay M.3 ple (mean rating of 6.8 out of 10) and paediatric clinicians (87.5%
1 Mayo Clinic, Psychiatry, Rochester, USA; 2 Mayo Clinic,
rating receiving and addressing YouthCHAT results in clinic as
Cardiovascular Surgery, Rochester, USA; 3 Mayo Clinic, acceptable or very acceptable). YouthCHAT screening took a mean
Cardiovascular Diseases, Rochester, USA of 6.35 (3.1–16) minutes to complete and identified cases of both
depression and anxiety. Apart from a need for a strong WiFi signal,
Background and aims.– Left ventricular assist devices (LVAD) are YouthCHAT proved to be feasible to use in an outpatient setting.
increasingly utilized as bridge to transplant (BTT) or destination Conclusions.– YouthCHAT may provide a viable option for undertak-
therapy (DT) for patients with advanced heart failure. There is lim- ing routine or opportunistic psychosocial screening in an efficient
ited evidence regarding the effect of depression on these patients. and acceptable manner.
We hypothesized that DT recipients would have more severe Disclosure of interest.– The authors have not supplied a conflict of
depression pre-implantation than BTT recipients. We also hypothe- interest statement.
sized that somatic symptoms would contribute more to depressive
E-PP0318 Results.– 32 GPs (80%) responded to our questionnaire and 18 GPs

“WHIZZ! It moves, broom! it vibrates, participated in FGs. Three sets of expectations emerged regard-
fisst! it stretches”. case report of a ing referral: dealing with confrontation to their treatments’ limits;
protecting or improving the doctor-patient relationship; avoid-
baillarger’s hipochondriac delusion in ing undesirable consequences for the GP himself (self-esteem and
a patient with neurosyphilis recognition issues). Various factors associated with referral moti-
L. Tost1* , H. Hernández Tost2 , J. Rodríguez Alvarez-Cienfuegos2 , J. vations or inhibitions are exposed in Figure 1.
Gutiérrez Naranjo2 , C. Morales Hernández2 , I. Rodríguez Baz2 , V.
González Coello2 , V. Mota Balibrea2 , J. Alonso Pérez2
1 University Hospital La Candelaria Tenerife, Psychiatric Department,
Santa Cruz de Tenerife, Spain; 2 University Hospital La Candelaria

Tenerife, Neurology Department, Santa Cruz de Tenerife, Spain
Background and aims.– A 63-year-old male patient with active alco-

holism was admitted to the hospital with aggressive behaviors,
confusional syndrome, memory disturbance and impaired balance.
The patient was diagnosed with organic brain syndrome related to
alcohol. He was later followed up by a neurologist because of a quick
worsening of cognitive functions and neurosyphilis diagnosis was
Figure 1. Themes constellation.
established by serum and CFR serological tests.
Methods.– After treatment with intravenous penicillin the patient GPs’ concerns and emotions are crucial during the referral process,
presented a cognitive and behavioral improvement but remained and are influenced by multiple dynamic interpersonal interactions:
having sensitive ataxia, hypoesthesia, diminished vibratory per- doctor-patient, GP-specialists and GP- supervisor/colleagues rela-
ception and reflexes, pricking sensation and burning pains tionships.
consistent with Tabes dorsalis. Conclusions.– Multiple personal and contextual factors motivate
Results.– A year after, the patient started with somatic and passiv- referrals to specialists. GPs’ lived experience and the relationships
ity delusions with cenestesical hallucinations. He described that he built within their work environment are crucial in referral pro-
could travel within his body observing his brain becoming inde- cess. CLPs’ interventions could help them to take into account
pendent and conducting a war against his body: “virus leave my (insight) and better manage these experiences; and to create
brain through the top of my skull, they get me drunk, remove nico- efficient healthcare networks by processing and interfering into
tine, my brain moves within the skull, commands me, provokes interpersonal interactions.
me pain, makes my organs shift and vibrate, stretches my stomach, Disclosure of interest.– The authors have not supplied a conflict of
manipulates my anus . . ..” interest statement.
Conclusions.– Neurosyphilis has become an unusual disease entity
thanks to early treatment. The main psychiatric forms include
expansive states with grandiose delusions and depressive forms. E-PP0320
Baillarger described in 1869 hypochondriac delusions poorly sys- Post-traumatic stress disorder and
tematized, childish, absurd and grotesque, variable and easily
suicidal ideation in traumatic spinal
suggestible, within the framework of syphilitic dementia. It was
postulated that delusion could be related to a reinterpretation cord injury: preliminary results of a
by the patient of proprioceptive dysfunction caused by syphilitic cross-sectional study
mielopathy’s damages. N.G. Usta Saglam1* , D. Dogan2 , C. Aksoy Poyraz3 , B. Erhan2
1 Istanbul Gaziosmanpasa Taksim Research and Training Hospital,
interest statement. Psychiatry Department, Istanbul, Turkey; 2 Istanbul Gaziosmanpasa
Taksim Research and Training Hospital, Physical Therapy and
Rehabilitation Department, Istanbul, Turkey; 3 Istanbul University
E-PP0319 Cerrahpasa Medical Faculty, Psychiatry Department, Istanbul, Turkey
General practitioners’ expectations
when referring to specialists; Background and aims.–
consulation-liaison psychiatrist’s Introduction.– Spinal cord injury (SCI) is a major traumatic event
perspective: a qualitative study that is associated with abnormal levels of psychiatric morbidity
K. Tzartzas1* , R. Marion-Veyron1 , P.N. Oberhauser2 which can interfere with rehabilitation and long-term management
1 University of Lausanne, Department of Ambulatory Care and of the patients.
Community Medicine, Lausanne, Switzerland; 2 University of Objectives.– To analyze unmet psychiatric needs in people with
Lausanne- UNIL, Faculty of Social and Political Sciences, Lausanne, traumatic spinal cord injury by exploring predictors and clinical
Switzerland correlates of persistent post-traumatic stress disorder (PTSD), sui-
* Corresponding author. cidal ideation and depression.
Methods.– A consecutive series of 40 inpatients receiving rehabilita-
Background and aims.– A referral rate of 9.44% is reported in tion for traumatic SCI who were at least 3 months post-injury were
Switzerland. General practitioners’ (GP) referring motivations interviewed. Turkish version of the PTSD Checklist for Diagnostic
have yet to be further investigated. This is a central issue for and Statistical Manual of Mental Disorders, Fifth Edition (PCL-
consultation-liaison psychiatrists (CLPs) who process medical 5), Suicidal Behaviors Scale, The Suicide Probability Scale, Patient
requests. Our aim was to describe GPs’ more or less conscient moti- Health Questionnaire (PHQ-9) and Brief Resilience Scale were used.
vations and experiences when they refer to specialists. Socio-demographic and clinical data were also collected.
Methods.– A questionnaire survey based on the existing literature Results.– Suicidal ideation was detected in 35% of patients. PTSD
was distributed to the GPs working at the Department of Ambula- prevalence was stated 22.5%. Suicide ideation, suicide probabil-
tory Care and Community Medicine of the University of Lausanne. ity and depression were significantly higher in patients with PTSD
Afterwards, two focus groups (FGs) were conducted.
(p < 0.001). Despite this high comorbidity rates, only 17.5% of his admission. Significant laboratory test (see table 1) were
patients were receiving any psychiatric treatment. rising Creatinine Kinase (CK); hypocalcemia; hyperkalemia;
Conclusions.– There is a need for increase awareness among health hypophosphatemia; hyponatremia and leukocytosis while electro-
care providers with psychiatric comorbidities in SCI. cardiogram showed tachycardia. He was diagnosed with NMS with
Disclosure of interest.– The authors have not supplied a conflict of atypical presentation after diagnoses like breakthrough seizure
interest statement. were excluded. SGA were stopped and he was managed in ICU
with supportive management. He improved markedly and was
discharged in 5 days.
E-PP0321
Seasonality and suicide attemps with
severe consequences in
consultation-liaison psychiatry
M. Villanueva* , F.J. Gómez Beteta, J.M. Del Rio
Hospital Clínico San Carlos, Psychiatry, Madrid, Spain
Background and aims.– Most suicides are a consequence of either

overflowing coping strategies or internal and external biological
risk factors. It is known that seasons modify the disease course
of mental disorders, as occurs in bipolar disorder. Several studies
about suicide have highlighted the impact of exposition to sun-
light, air pollution and pollination, among others, in the incidence
of suicide. Our aim is to study the influence of the seasonality in the
number of suicide attempts with severe consequences.
Methods.– For this purpose, we checked the clinical histories of Table 1. Significant laboratory test
recovered patients who were hospitalized in a medical or surgical Conclusions.– This case illustrated that adverse event of NMS can
service for suicide attempt and required consultation-liaison psy- occur in the long-term use of SGA. The patient may also remain
chiatry interventions from January 2016 to December 2017. We afebrile. It is important to consider NMS in all cases of delirium on
obtained a sample of 52 patients and registered their sociodemo- antipsychotics as a delay in diagnosis can be fatal.
graphic data, date of suicide attempt, and other clinical information. Disclosure of interest.– The authors have not supplied a conflict of
Results.– In our study sample, we found that attempted suicides interest statement.
occurred most frequently during fall (40.4%), while in winter and
spring we found a frequency of 25%; and a 9.6% in summer.
Conclusions.– These results contrast with similar researches, which
illustrate spring as the season with the largest suicide ratio. These E-Poster Presentation: Cultural
findings may be useful in order to assist planners for prevention at Psychiatry/Depression - Part VI
different times of the year.
interest statement.
E-PP0323
Consanguinity as a risk factor for
E-PP0322 severe mental illness: historical study
Atypical neuroleptic malignant of half-siblings
syndrome in an afebrile patient on C. Alario Ruiz* , A. Royuela Rico, P. Herrera Gener, A. Hernández
second generation antipsychotic García, C. Rodríguez Fernández
P.P. Yap1* , V. Kwok2 , K.H. Tay2 , W.S.A. Chee2 , I. Rawtaer2 Psychiatry, Psychiatry, Palencia, Spain
1 Ministry of Health Holdings, Psychiatry, Singapore, Singapore; 2
Sengkang General Hospital, Psychiatry, Singapore, Singapore
* Corresponding author. Background and aims.– The role of consanguinity as a risk factor for
serious mental illness continues to be a subject of debate today.
Background and aims.– Neuroleptic malignant syndrome (NMS) is There are 2 basic techniques to study this problem: the so-called
rare but potentially fatal. It classically presents with altered mental Runs of Homozygosity (ROH), and the study of genealogical trees.
status, fever, muscle rigidity, and autonomic dysfunction. However, The study of genealogical trees has obtained inconclusive results,
the presentation can be atypical and may be associated with second perhaps due to the fact that, in general, studies have been limited
generation antipsychotics (SGA). Pathophysiological mechanism in to a maximum of 6 generations. This problem could be overcome
SGA may be due to dopamine receptor antagonism in hypotha- by studying the ancestors of the royal families, in which there is no
lamus; nigrostriatal region and skeletal muscles. This case study such limitation.
describes a case of NMS that presented with atypical symptoms. This work studies the coefficient of inbreeding in 8 pairs of siblings
Methods.– This is a case study of a 54 years old Chinese gentle- with only one common parent (half-brothers) belonging to Euro-
man with Schizophrenia, Intellectual Disability and Epilepsy on pean royal families, in which one of them might have been affected
phenytoin. His other medications were Risperidone 4 mg; Sulpiride by a mental illness.
1200 mg and Benzhexol 4 mg each day. He presented to a general Objectives.– To determine if the coefficient of inbreeding is higher
hospital in Singapore with altered mental status, agitation, gener- in the sick sibling than in the healthy one.
alized rigidity, decreased verbal output, diaphoresis and retention Methods.– A historical study was conducted about possible mental
of urine. illnesses in European royal families, with special attention to cases
Results.– Physical examination found diaphoresis; tachycardia; involving half-brothers. Genealogical trees were created using the
hypertension; generalized rigidity; dyskinetic movements and PED-PRO program, with a database of 25,178 individuals, calculat-
resting tremors. However he remained afebrile throughout ing the coefficient of inbreeding (F) for 24 generations.
Results.– Will be shown in the poster as a graphic.
Conclusions.– Coefficient of inbreeding is greater in the sick half- Methods.– This media lab will examine and discuss the treatment of
brother than in the healthy one. refractory depression with ayahuasca in Native American cultures
The study of large genealogical trees of royal families provides through the “Last Shaman” 2016 movie.
greater detail in the determination of the coefficient of inbreeding Results.– The media covered allows the debate on the controver-
and its risks. sial use of culturally established alternatives with no foundation
According to these results, consanguinity is a risk factor for serious in scientific literature. It is also possible to discuss the cultural
mental illness. influence on psychopathological understanding in these tribes and
Disclosure of interest.– The authors have not supplied a conflict of the neuropsychiatric/neurobiological repercussions of the use of
interest statement. Ayahuasca- a psychedelic substance- in patients with a psychiatric
history. Ayahuasca is composed by the N-dimethyltryptamine, a
serotonin and sigma-1 receptors agonist, and reversible IMAO A,
E-PP0324 causing changes in perception, emotion and cognition. Studies sug-
Celebrities’ disclosure about mental gest its antidepressant potential, and demonstrate its safety and
health and stigma: will Mariah Carey tolerability. These studies associate the potential action in long-
term modulation of the serotonergic system, HHA axis and immune
be our Angelina Jolie?
system, with an increase in prolactin, cortisol and reduction of
J.V. Blanc1* , L. Malandain2 , S. Mouchabac1 , F. Ferreri1 , P. Nuss1
1 CD3/CD4, affecting the evolution of the depressive disorder.
Saint Antoine Hospital - AP-HP- Sorbonne University, Psychiatry
Conclusions.– Our proposal is to discuss the ethical, social and
and Medical Psychology Departement, Paris, France; 2 Sorbonne
mental health impact of the use of Ayahuasca in cases of major
University, Psychiatry and Medical Psychology Departement, Paris,
depressive disorder including risks, biological basis, placebo effect
France
* Corresponding author. and the dissemination of this cultural practice around the world.
Background and aims.– Stigma surrounding mental health is very interest statement.
frequent, preventing patients from seeking care and increasing the
burden of mental disorders. On April 11, 2018, singer Mariah Carey
disclosed that she had Bipolar Disorder II in an interview for People E-PP0326
magazine. Celebrity statements about health can be a powerful way The opinion of tunisian medical
to raise awareness in the general population and for patients to students on corporal punishment
enter the healthcare system. This so-called “Angelina Jolie Effect”, M. Ghazzai1* , L. Jouini2 , R. Ben Massoued3 , S. Halayem1 , Z.S. Abbes
has been studied since 2013, when the American actress published Ghorbel1 , M. Hajri1 , A. Bouden1
an opinion column in The New York Times, in which she shared her 1 Razi Hospital, Department of Child and Adolescent Psychiatry,
decision to undergo a prophylactic bilateral mastectomy after she Mannouba, Tunisia; 2 Razi Hospital, Psychiatry A, Mannouba,
learned she had a deleterious BRCA1 mutation. Tunisia; 3 Razi Hospital, Psychiatry B, Mannouba, Tunisia
Methods.– Our study’s aim is to examine the impact of Mariah * Corresponding author.
Carey’s interview about bipolar disorder with data analysis on

Google Trends and a content analysis on People Magazine’s social Background and aims.– A growing number of studies have shown
media page related to the article (182 comments, 93 on Twitter and that corporal punishment (CP) is ineffective and harmful. How-
89 on Facebook). ever cultural diversity poses challenges and CP is still considered
Results.– The search query “bipolar disorder” reached its 5-year an acceptable method of discipline among Tunisian population.
peak in popularity on Google in April 2018 in the USA. In con- Understanding the opinion of future doctors is important to estab-
tent analysis, supportive comments about disclosure were the most lish preventive strategies.
common theme (n = 49, 27%), followed by fan comments (n = 33, Objectives.– The aim of this study was to assess the opinion of the
18%), closely followed by stigma or hatred comments (n = 27, 15%). medical student about the use of CP
Conclusions.– There is a large public interest in celebrities’ disclo- Methods.– A self-questionnaire has been completed by Tunisian
sures about mental health and this could be a great opportunitiy to medical students. They were asked about their personal history of
raise awareness in the general population. Stigma toward bipolar CP and their opinions about physical discipline.
disorder is still high on social media platforms. Results.– Our sample is composed of 140 medical students, aged
Disclosure of interest.– The authors have not supplied a conflict of between 18 and 28 years old (M = 22, SD = 1.68) with a sex ratio of
interest statement. 0.46. 71.4% of them reported a history of CP and 7.1% thought that
they have been the victim of physical abuse. There was a signif-
icant association between history of CP and prediction of future
E-PP0325 use of corporal punishment (2 , p = .003). The mother used the
The last shaman: understanding the physical discipline in 73.2%, the father in 64.9% and the teachers
in 44.8% of the cases. CP was thought to be common in our society
refractory depression and the possible
by 96.2%. Major reasons why parents use CP were: they were raised
basis of ayahuasca’s cultural solutions the same way (62%), they don’t believe it’s harmful (51%). 89.8% of
M.L. De Falco1* , L. Peroni1 , N. Haddad2 the students believed using CP could have negative downsides.
1 FMABC Brazil, Psychiatry, São Paulo, Brazil; 2 FMABC, Psychiatry, Conclusions.– It’s necessary to understand the cultural context of
São Paulo, Brazil CP, in order to navigate between respecting cultural norms and
assessing what can be harmful for the child.
Background and aims.– “The last shaman” is a documentary that Disclosure of interest.– The authors have not supplied a conflict of
discusses the search for a young man to cure a refractory depres- interest statement.
sion. It shows moments of extreme negativism and refractoriness
of the protagonist’s depression, initially submitted to pharmaco-
logical treatments and ECT. Having no answer to these therapeutic
options, he began to search in Peru and Amazonia for methods of
shamanic healing, culturally popular in these local communities of
Latin America.
E-PP0327 were 1.16 (95%CI: 1.01, 1.33) times more likely than pre-war
Ernest Jones and British cohorts to have schizophrenia. Sensitive analyses show that our
Psychoanalysis estimates of war effect on schizophrenia were robust and valid.
M. Goujon Conclusions.– Prenatal exposure to the Sino-Japanese War of
Cambridge University Hospital, CAMEO Early Intervention for 1937–1945 had long-run detrimental effect on risk of schizophre-
Psychosis, Cambridge, United Kingdom nia in the female adults. Further investigations are warranted to
Background and aims.– Remembering 100 years since the end of extend the enduring wartime impact on other health outcomes in
World War I, it is time to revisit the contribution of Dr Alfred Ernest China.
Jones (1879 –1958), president of both the International Psychoan- Disclosure of interest.– The authors have not supplied a conflict of
alytical Association and the British Psycho-Analytical Society (BPS) interest statement.
to British Psychoanalysis.
Methods.– Relevant writings were evaluated.
E-PP0329
Results.– Jones was particularly inspired by Sigmund Freud’s the-
ories on psychosexual development during his early work on Comparison of clinical and
shell-shock. Jones was not only Freud’s disciple but also his biogra- sociodemographic variables between
pher and a close friend to him and his daughter Anna. Later, Jones Spanish and Moroccan patients
ideas drifted from Freudian doctrine under the influence of Melanie hospitalized in a Spanish psychiatric
Klein’s work on child psychology and he originated with the con-
unit
cepts of “phallocentrism” and “aphanisis”. He subsequently became
E. Nieto, M. Khatib* , M. De Chiara, C. Isern, S. Biel, M. Puig
the instigator of the Freud-Jones controversy: distinguishing the
Althaia Xarxa Assistencial Universitaria, Psychiatry, Manresa, Spain
study of dreams or use of free association from the “true Freudian * Corresponding author.
method”.
Ernest Jones is a lot less known for his key role in Freud’s exile to Background and aims.–
London during the Nazi invasion in World War II as he convinced Background.–Transcultural psychiatry shows that presentation and
the famous psychoanalyst to flee the unrest. In fact, Jones not only prevalence of different mental disorders and suicidal behaviour
helped Freud to immigrate to Britain but a significant number of changes across the different cultures, religions and races. The emi-
psychoanalysts who were to become pillars of the BPS and bring gration of population (mostly young people) is associated with
their expertise to various parts of the country. greater prevalence of mental disorders specially psychotic disor-
Jones, indefatigable and talented, was a pioneer in interna- ders.
tional psychiatric relations. We owe him both the American Aims.–
Psychopathogical Association and the American Psychoanalytic 1. To determine the % of Moroccans hospitalized in a Spanish psy-
Association. chiatric unit
Conclusions.– In the present day, it is important to emphasise the 2. To determine the signicantly different clinical and socide-
advantage of putting ‘brains together’ to allow progress. mographics characteristics between Spanish and Moroccan
Disclosure of interest.– The authors have not supplied a conflict of inpatients
interest statement. Methods.– Patients: We include all psychiatric patients hospitalized
in the Psychiatric Unit of General Hospital (Spain) in the last nine
years.
E-PP0328 Method.– We reviewed, retrospectively and annually, the clinical
Prenatal war exposure and chart records of the hospitalization of all inpatients and we regis-
schizophrenia in adulthood: evidence tered 80 clinical and sociodemographic variables.
from the Sino-Japanese War of Statystics.– In multivariate analysis (with Moroccan origin as
dependent variable) we used logistic regression test including the
1937-1945
qualitative variables significantly associated (Chi-square) in uni-
P. He
variate analysis as independent variables.
Peking University, China Center for Health Development Studies,
Results.– A total of 3890 patients were hospitalized,3592 were
Beijing, China
* Corresponding author. Spanish and 157 (4% moroccan inpatients compared to the 8%
Moroccan of the whole population in our region). The next Table 1
Background and aims.– War has a profound damage to human shows the odd ratio and confidence interval of variables that remain
health and well-being and become a serious public health prob- significantly associated in multivariate logistic regression analysis.
lem. However, limited evidence is known regarding the long-term
impact of war on mental health in developing nations. This study
aimed to examine the long-term effect of prenatal exposure to the
Sino-Japanese War during 1937–1945 on risk of schizophrenia in
adulthood among Chinese wartime survivors.
Methods.– We obtained data from the Second National Sample Sur-
vey on Disability conducted in 31 provinces in 2006. We restricted
our analysis to 369,469 adults born between 1931 and 1950.
Schizophrenia was ascertained by psychiatrists based on the Inter-
national Statistical Classification of Diseases 10th Revision. War
intensity was assessed by the ratio of war-caused civilian causali-
ties to the pre-war population. The effect of prenatal exposure to
war on schizophrenia was estimated by difference-in-difference
models, established by examining the variation of war across birth
cohorts.
Results.– In the male population, war cohorts of 1937–1946 had no
significant higher odds of schizophrenia compared with the pre-
war cohorts of 1931–1936. In the female population, war cohorts
Table 1. the odd ratio and confidence interval of variables that Background and aims.– Significant barriers have been described in
remain significantly associated in multivariate logistic regression the literature for indigenous people to obtain medical care. In all
analysis. countries studied, indigenous people have worse physical and men-
Conclusions.– tal health than the non-indigenous population and have greater
- The prevalence of Moroccan psychiatric inpatients is underrep- problems accessing health care. One of the problematic areas lies
resented (4% compared to the 8% Moroccan people of the whole in the provider-patient relationship and patterns of communica-
population in our region) tion. We set out to develop a training program to help providers
- The Moroccan psychiatric inpatients are significantly younger, communicate more effectively with indigenous patients.
of male gender, suffer more psychotic disorders, consume more Methods.– The training program consisted of a series of video
cannabis, leave more the treatment, make lower previous sui- lectures with live discussion sections, practice interviews with
cide attempts and are treated more frequently with long-acting indigenous patients, and an immersion period in the indigenous
injectable antipsychotic treatment. community to experience life within that community. Trainees
Disclosure of interest.– The authors have not supplied a conflict of learned to allocate more time for indigenous patients so that social
interest statement. yarning could occur prior to diagnostic and treatment yarning
(yarning being an Australian aboriginal term for ‘talking story”).
They learned about the primacy of relationship for indigenous
E-PP0330 people (to people and to place). They learned circle processes for
The ottawa self-injury inventory interacting in traditional ways with the patient’s family and com-
version 3.1 speaks many languages: a munity as part of the creation of the treatment yarn. They learned
about the role of ceremony and the infusion of spirituality as an
systematic review of the literature
everyday part of life.
C.A. Lewis1,2* , S. Davis3 , M.J. Lewis3
1 Results.– Trainees reported improved understanding of indigenous
Bishop Grosseteste University, School of Social Sciences, Lincoln,
patients and their cultures and increased competence in interact-
United Kingdom; 2 University of Warwick, Centre for Education
ing with these patients. The indigenous patients reported greater
Studies, Coventry, United Kingdom; 3 Glyndŵr University,
comfort with the providers. Cultural competence improved.
Psychology, Wrexham, United Kingdom
* Corresponding author. Conclusions.– An experiential, immersion program focused around
listening to stories, telling stories, eliciting stories, and co-creating
Background and aims.– The growth in research on self-harm (non- a treatment/management story or yarn was more successful than
suicidal self-injury), has been accompanied by an increase in the conventional didactic approaches to teaching cultural competence.
number of psychometric measures available to measure self-harm. Disclosure of interest.– The authors have not supplied a conflict of
The Ottawa Self-injury Inventory version 3.1 (OSI 3.1) has been used interest statement.
in an increasing number of studies. The OSI 3.1 contains 26 items
and is made up of four subscales (occurrence, frequency, func-
tions, and addictive features). The OSI 3.1 was developed in English E-PP0332
and has been translated into a variety of different languages. The Reconciliation justice circles for child
present aim was to review previous research that has employed the sexual abuse: healing or traumatizing
OSI 3.1 in order to critically examine the utility of the measure. for indigenous people
Methods.– A systematic search of pertinent research databases L. Mehl-Madrona
was undertaken to examine the use of the OSI 3.1. Subsequently, University of Maine, Graduate School, Orono- Maine, USA
comparative analysis was undertaken between research identified * Corresponding author.
using the various linguistic versions of the OSI 3.1.
Results.– The majority of the research identified was undertaken Background and aims.– Reconciliation Justice Circles (RJC) have
using the English, German, and French language versions of the OSI emerged as alternative sentencing strategies for indigenous people
3.1, and was conducted among young people. Three critical points in North America and are spreading to Europe. Beginning with the
with the OSI 3.1 were identified. First, a variety of translation pro- perpetrator acknowledging guilt, the circle uses traditional indige-
cedures have been employed, though typically the back-translation nous cultural practices and methods of communication to create a
method has been favoured. Second, there is evidence for the relia- plan for reconciling all the stakeholders in the crime including the
bility and validity of the subscales of the various translated versions. families of all parties involved in a process to restore balance and
Third, caution is noted when comparing prevalence rates across the harmony in the community. Its use in child sexual abuse is contro-
different samples and cultures. versial. In this context, psychiatrists may be asked if individuals are
Conclusions.– The outcome of this systematic review provides sat- able to engage in this process and little data exists to inform their
isfactory evidence that the OSI 3.1, in its’ various linguistic forms, opinion.
is a valid and reliable measure of self-harm. Methods.– From a larger study of life stories of indigenous people
Disclosure of interest.– The authors have not supplied a conflict of related to spiritual practice and health outcome, we found 99 sto-
interest statement. ries in which child sexual abuse had occurred. Among 19 of those
stories, RJCs had been used. Sixteen stories involved RJC practices
in which a proxy sat-in for the perpetrator. The remainder of the
E-PP0331 stories involved the conventional criminal justice system. Teams of
Development of a curriculum for graduate students rank ordered the stories for their sense of well-
improving communication of mental being and personal resolution of the experience. The Kruskal-Wallis
statistic was used to determine differences in rank among the three
health clinicians with indigenous
groups
people Results.– Participation in RJC was associated with the life stories
L. Mehl-Madrona1 , B. Mainguy2* , P. McFarlane3 being ranked statistically significantly higher (p < 0.0001). Actual
1 University of Maine, Graduate School, Orono- Maine, USA; 2 RJC was almost higher ranking than proxy RJC (p = 0.06).
University of Maine at Orono, School of Social Work, Orono, USA; 3 Conclusions.– Among this population, we found no evidence that
University of New England - Bangor, Family Medicine, Orono, USA RJC had negative effects upon the survivors who participated in
them and may have been beneficial.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– A total of 340 in- and outpatients (66,1% male) mean
interest statement. age 49,76 SD 11,352 were included in survey performed from
October 2017 to February 2018 in Neuropsychiatric Hospital in
Popovača, Croatia. Patients were assessed with structured ques-
E-PP0333 tionnaire about their preference to psychiatrist’s gender, age group,
“Going off the beaten track”: a review how they like to be addressed (by name, title and surname, neutral)
on travel-related psychosis and how they prefer to address the psychiatrist (by name, title and
A. Samouco1* , F. Caetano2 , M. Araújo2 , M. Barros2 , C. Agostinho1 surname, neutral).
1 Unidade Local de Saúde do Norte Alentejano- E.P.E., Departamento Results.– The majority of the male patients are neutral about psy-
de Psiquiatria e Saúde Mental, Portalegre, Portugal; 2 Hospital de chiatrist gender. Female participants are more likely to choose
Magalhães Lemos- E.P.E., Departamento de Internamento, Porto, female psychiatrist (p = 0,019; df = 2; ␹2 = 7,876). Both, male and
Portugal female prefer psychiatrist to be between 35 and 50 years old. Both
* Corresponding author. patients’genders are comfortable with being addressed by name or
they showed to be neutral about the form of addressing, but were
Background and aims.– Travelling constitutes a stress-inducing less likely to choose being called by title and surname. Both gen-
environment, which has been associated in literature with the ders have chosen that the most appropriate form to address the
development of mental health problems, including psychotic psychiatrist is by title and surname.
symptoms (Travel-related psychosis). The purpose of this review Conclusions.– Our results show that patient’s gender affects their
is to summarize the existing data on this topic. attitude toward psychiatrist gender, age and addressing form.
Methods.– A research was performed on PubMed using the terms Disclosure of interest.– The authors have not supplied a conflict of
“travel” and “psychosis”; the resulting articles were subsequently interest statement.
reviewed and summarized.
Results.– The literature on Travel-related psychosis is scarce. Its
occurrence has been reported more frequently in the context of E-PP0335
travel to high cultural value destinations (e.g. Jerusalem, Paris and Effectiveness of a culturally-adapted
Florence); however, it is not clear whether it is more likely to behavioural family psychoeducational
occur in these locations. It may constitute an exacerbation of a pre-
programme on the attitude of
viously diagnosed psychotic illness, a first-episode of psychosis,
the result of substance abuse/withdrawal, or the consequence of caregivers of patients with
a medical disorder (e.g. infections). It has been associated with schizophrenia: an Egyptian study
several potential contributing factors, including disruption in cir- M. Sultan1* , G. El Nahas2 , H. Ramy2 , D. El Gabry2 , R. Bassim2 , R. El
cadian rhythms (insomnia, jet-lag), fatigue, dehydration, irregular Ghamry3
1 Institute of Psychiatry, Department of Psychiatry, Cairo, Egypt; 2
food intake, drug use, prolonged travel in relative confinement and
isolation, cultural shock and loss of control. Treatment approaches Institute of Psychiatry- Ain Shams University, Neuropsychiatry, Cairo,
include antipsychotic medication and melatonin, although some Egypt; 3 Institute of Psychiatry-Ain Shams University,
reports suggest the symptoms could resolve spontaneously within Neuropsychiatry, Cairo, Egypt
few weeks; repatriation to a familiar environment should also be
facilitated.
Conclusions.– Travel-related psychosis constitutes a difficult situa- Background and aims.–
tion for both patients and local medical professionals. Considering Background.– Few studies in Egypt have examined the effectiveness
the growing number of international travellers, clinicians must of psychoeducational programmes as an adjunct to pharmacother-
be aware of travel-related mental problems, and patients with apy in patients with schizophrenia. This is especially relevant
a pre-existing mental illness should be offered pre-travel advice. because of the traditional collectivistic nature of the Egyptian cul-
Additional research is needed to further clarify this phenomenon. ture, where the primary (especially financial) responsibility falls on
Disclosure of interest.– The authors have not supplied a conflict of families and not to society at large.
interest statement. Aim.– We aimed to study the effect of a culturally-adapted
behavioural psychoeducational programme on the attitude of a
sample of the caregivers of patients with schizophrenia in Egypt.
E-PP0334 Methods.– Thirty caregivers of patients with schizophrenia were
randomly selected to receive 14 sessions of a culturally-adapted
How does patient’s gender affect their
behavioural family psychoeducational programme (CA-BFPEP). A
attitude toward psychiatrists? matching control group of 30 caregivers on all outcome param-
M. Škarić1* , B. Margetić2 , B. Aukst-Margetić3 , Z. Borko-Ivandić1 , eters received standard treatment as usual (STU) for 6 months.
M. Kovač1 Pre- and post-intervention assessment included primary outcomes
1 Neuropsychiatric Hospital ‘Dr. Ivan Barbot’, Psychiatry, Popovača,
that assessed clinical, social, quality of life and attitude towards
Croatia; 2 Clinical Hospital Dubrava, Psychiatry, Zagreb, Croatia; 3 medications measures, using the Arabic versions of the Commu-
Clinical Hospital Centre Sestre Milosrdnice, Psychiatry, Zagreb, nity Attitudes Toward the MentallyIll (CAMI) and Knowledge about
Croatia Schizophrenia Interview (KASI).
Results.– There was a statistically significant difference (p < 0.001)
between pre- and post- treatment scores for caregivers receiving
Background and aims.– Understanding patients’ needs and expecta-
CA-BFPEP on CAMI and KASI scores. There was also a statistically
tions from psychiatrist is important for building a good therapeutic
significant difference (p < 0.001) between cases receiving CA-BFPEP
alliance. Gender affects our attitudes and perception and accord-
and controls receiving STU on intervention outcome measures
ingly may affect patients’ preferences in choosing a therapist. To
using CAMI and KASI.
our knowledge, such research is scarce and so far has not been
Conclusions.– These results demonstrate the feasibility and effec-
conducted in Croatia.
tiveness of implementing family therapy psychoeducational
With this survey we wanted to evaluate gender specific differences
interventions in different cultural settings, with relatively minor
in patients’ preference to psychiatrist gender, age and forms of
modifications. This may have implications for mental health pol-
addressing.
icy makers to make such programmes available for patients and GABRA6 gene in interaction with stress showed a strong effect on
mental health professionals. suicide risk. We compared the effect of the two variants in interac-
Disclosure of interest.– The authors have not supplied a conflict of tion with recent stress on suicide-related risk phenotypes.
interest statement. Methods.– 2206 subjects genotyped for GABRA6 rs3219151 and
CNR1 rs7766029 completed the Brief Symptom Inventory, and pro-
vided information on recent stressors. Data were analysed using
E-PP0336 linear regression models testing gene-by-environment effects on
How ethiopean individuals each depression and anxiety symptom.
comprehend social cognitive tests Results.– rs3219151 in interaction with stress influenced more
depression-related suicide risk items and with a stronger effect
developed for European individuals. a
than rs7766029 (e.g. thoughts of ending life p = 0.004 vs p = 0.041;
cross-cultural study feeling hopeless about the future p = 0.019 vs p = 0.048; feelings
E. Varga1* , K. Tesfay Berhe2 , A. A. Damte2 , T.B. Mossie2 , T. Tényi1 , of worthlessness p = 0.004 vs p = 0.034; feelings of guilt p = 0.002
R. Herold1 , T. Bugya3 vs p = 0.683, for rs3219151 and rs7766029 respectively), except
1 University of Pécs, Department of Psychiatry and Psychoterapy,
for thoughts of death or dying where rs7766029 had a more pro-
Pécs, Hungary; 2 Mekele University, Mental Health, Mekelle, Ethiopia; nounced effect (p = 0.002 vs p < 0.001). Only rs3219151 had an effect
3 University of Pécs, Department of Cartography and Geoinformatics,
on anxiety-related suicide risk including spells of panic (p < 0.0001)
Pécs, Hungary and extreme restlessness (p < 0.001).
Conclusions.– Both variants had a strong effect on suicide risk-
Background and aims.– Social cognitive deficits are remarkable fea- related phenotypes in interaction with stress, however the effect
tures of many psychiatric disorders. There are several tests to was stronger in case of GABRA6 especially on thoughts of suicide,
measure social cognition of mentally ill patients in the European feelings of worthlessness, hopelessness and guilt, and unlike CNR1,
culture, however it is still a question, whether these tests can it also had a strong effect on intense restlessness and drive to act
be used in other, non-Western cultures. In the present study, we immediately. Thus GABRA6 offers a possible target for pharmaco-
investigated how Ethiopian individuals comprehend social cogni- logical intervention in suicide risk.
tive tests developed for Europian individuals. We hypothesized that Disclosure of interest.– The authors have not supplied a conflict of
Ethiopian individuals would have some difficulties comprehending interest statement.
these tests due to cultural differences.
Methods.– 36 healthy Tigrinya university students (EG) and 36
E-PP0338
matched, healthy Hungarian students (HG) were investigated. Par-
ticipants took the tests in their own language. Social cognition was Reward related learning and
assessed with SCAN software (scan.ttk.pte.hu), which can detect anhedonia in depression and
response rates, response times and mouse-handling times. The fol- remission: a controlled
lowing social cognitive domains were examined: Theory of Mind cross-sectional study
(Faux pas Test, Eyes Test), pragmatic language (irony and metaphor A. Gürcan1* , K. Başar2
tests), emotion perception (Face test, pairing facial and postural 1 Yozgat City Hospital, Psychiatry, Yozgat, Turkey; 2 Hacettepe
emotions), social perception, gesture comprehension and empathy. University Faculty of Medicine, Psychiatry, Ankara, Turkey
Results.– The EG was significantly slower in all tasks (p < 0.0001), * Corresponding author.
while mouse-handling times of the groups did not differ signifi-
cantly (p = 0.278). The two groups performed similarly in the Eyes Background and aims.– Anhedonia is one of the core symptoms of
Test (p = 0.923) and in the Face Test (p = 0.086), however, the EG depression, the degree of which is associated with overall sever-
performed significantly worse in the remaining tests (p < 0.0001). ity and treatment resistance. Anhedonia is currently considered a
In the metaphor test the difference between the performance of the multifaceted construct, broadly including deficits in wanting, lik-
two groups was p = 0.021. ing and learning dimensions. In different mental health conditions,
Conclusions.– Our results show that social cognitive tests developed changes in diverse dimensions are proposed to be responsible from
for European individuals might be inappropriate to measure social the anhedonia assessed clinically.
cognition in Ethiopian individuals. Our results are probably due to It was aimed to compare reward related learning (RRL) in patients
significant cultural differences between the two groups. with major depression and those with history of remitted depres-
Disclosure of interest.– The authors have not supplied a conflict of sion, and healthy individuals.
interest statement. Methods.– Participants were enrolled into either ‘Remitted Major
Depression’ (RMD, n = 35), ‘Major Depression’ (MD, n = 15) or
‘Control’ (C, n = 37) groups, according to their current clinical assess-
E-PP0337 ment and history. Probabilistic Reward Task (PRT) was used to
Effects of genetic variation in two assess RRL. Participants were also evaluated with Chapman Phys-
distinct neurotransmitter systems on ical and Social Anhedonia Scales, Clinician Administrated Snaith
Hamilton Pleasure Scale Turkish Version (SHAPS-C-TR).
suicide risk-related phenotype
Results.– There was no significant difference between three groups
profiles: cnr1 and GABRA6 with respect to reward related learning performance. SHAPS-C-TR
X. Gonda1* , N. Eszlari2 , D. Baksa2 , P. Petschner2 , S. Sutori2 , Z. Gal2 , scores, which overlap with the clinical assessment of anhedonia,
S. Koncz2 , S. Kumar2 , G. Juhasz2 , G. Bagdy2 of MD group was higher than RMD and C groups. The sample was
1 Semmelweis University, Department of Psychiatry and
divided into anhedonics (n = 12) and non-anhedonics (n = 75) using
Psychotherapy, Budapest, Hungary; 2 Semmelweis University, SHAPS-C-TR scores as the threshold criteria. Following analysis
Department of Pharmacodynamics, Budapest, Hungary revealed that the anhedonic group performed significantly worse
in PRT.
Background and aims.– The CNR1 endocannabinoid receptor has Conclusions.– In contrast to clinically assessed consummatory
been one of the most promising obesity drug targets, however, anhedonia which appears to be state dependent and associated
drugs acting on this receptor including rimonabant precipi- with the presence of depressive symptoms, the deficits in reward-
tated severe side effects possibly increasing suicide risk. Recently related learning are not uniformly shown in patients with major
depression. RRL has stronger association with the experience of Methods.– The research method was descriptive and correlational.
anhedonia, rather than the current or life-time presence of major The statistical samples consisted of 80 married people that were
depression. selected and responded to Van der Zee et al’s Multicultural Per-
Disclosure of interest.– The authors have not supplied a conflict of sonality Questionnaire (Short Form, with subscales of Cultural
interest statement. empathy, Flexibility, Social Initiative, Emotional stability and Open-
mindedness), Ahwas’s Psychological Hardiness Scale and Key’s
Social Health Inventory. The data were analyzed by Pearson cor-
E-PP0339 relation formula.
Hypertension, socioeconomic status Results.– The results showed that there was a positive and signif-
and depressive symptoms in Chinese icant correlation between subscales of cultural personality traits
with social health and psychological hardiness in married people.
middle-aged and older adults:
Conclusions.– The findings can be used in family counseling centers
findings from the China health and and family educational programs for increasing the social health
retirement longitudinal study and psychological hardiness in married people.
Y. Jin1 , Y. Luo2 , P. He3* Disclosure of interest.– The authors have not supplied a conflict of
1 Peking University, Department of Global Health- School of Public interest statement.
Health, Beijing, China; 2 Peking University, APEC Health Science
Academy- Institute of Population Research, Beijing, China; 3 Peking
University, China Center for Health Development Studies, Beijing,
China E-Poster Presentation: Depression - Part II
Background and aims.– Depressive disorders have become a major

E-PP0340
mental health problem in middle-aged and elderly adults and is
predicted to be the second leading causes of disability by 2020. Retinal electrophysiology
Hypertension is proposed as a key risk factor for depressive symp- disfunctions in patients with MDD
toms biologically and psychosocially. This study was to examine E. Dańczura1* , W. Lubiński2 , J. Samochowiec1 , J.
the effect of hypertension on depressive symptoms and socioeco- Kucharska-Mazur1 , H. Grabek-Kujawa2
1 Pomorski Uniwersytet Medyczny SPSK-1 PUM, Psychiatry, Szczecin,
nomic status (SES) as moderator in the effect in middle-aged and
older adults in China. Poland; 2 Pomorski Uniwersytet Medyczny SPSK-2 PUM,
Methods.– We used data from the nationally representative sur- Ophtalmology, Szczecin, Poland
vey of China Health and Retirement Longitudinal Study, including
6,273 participants free from depressive symptoms at baseline in
Background and aims.– Depression is a multifactorial disease with a
2011–2012. We assessed the depressive symptoms based on the
complex and not fully recognized etiology. Currently, it is believed
10-item Center for Epidemiological Studies Depression scale. We
that the pathogenesis of depressive disorders, as well as the
conducted Cox proportional hazards regression models to exam-
response to pharmacotherapy depends on the adaptive mecha-
ine the effect of baseline hypertension status on the subsequent
nisms of nerve cells.
depressive symptoms in 2011–2015.
The study was designed to investigate the problems of functional
Results.– The hypertensive participants were more likely to have
retinal impairment in patients diagnosed with depression as a
depressive symptoms than non-hypertensive peers (HR = 1.12, 95%
potential biomarker of depressive disorders.
CI: 1.02–1.23) after adjusted for controlled variables. The effect only
Methods.– The study included 30 patients diagnosed with: depres-
occurred in the group of low SES, with rural residency (HR = 1.13,
sive episode (F32 according to ICD-10) or recurrent depressive
95% CI: 1.02–1.26), below-average household income (HR = 1.14,
disorders (F33 according to ICD-10), aged 18–65.
95% CI: 1.02–1.26) and primary school or below educational attain-
Depressive symptom severity was assessed with the Hamilton
ment (HR = 1.12, 95% CI: 1.00–1.25).
Depression Scale (HAM-D) and Beck Depression Inventory, fol-
Conclusions.– Hypertension is a chronic stressor leading to depres-
lowed by electrophysiological examinations of the retina: flash
sive disorders, and the responses to this stressor merely occurred
electroretinography (fERG), pattern induced electroretinography
among the low socioeconomic individuals. Our findings shed lights
(PERG), and visual evoked potentials (VEP). The procedure involved
on the action to prevent and control hypertension, which may con-
two psychiatric and opthalmological examinations: before and
tribute to fighting against depressive symptoms, especially in the
after pharmacotherapy with SSRI or SNRI drugs.
low socioeconomic population.
Results.– To date, the performed statistical analysis of PERG results
in fourteen patients before pharmacotherapy, compared with the
interest statement.
control group matched for sex and age, suggest statistically signif-
icant differences between the groups.
E-PP0339A Conclusions.– Although the study is still ongoing, initial results
remain in accordance with previous reports that the dysfunction of
Correlation between cultural the retinal cells is observed in patients with depression. The retina
personality with social health and of the eye, due to its embryonic origin, is a direct part of the central
psychological hardiness in married nervous system. It is believed that changes in retinal cell activity
staff people may reflect changes in neurotransmission that underlies mental
A. Homayouni1* , P. ZabihiniaGerdroudbari2 disorders.
1 Department of Psychology, Bandargaz Branch, Islamic Azad Disclosure of interest.– The authors have not supplied a conflict of
University, Bandargaz, Iran; 2 Department of Women Surgery- interest statement.
Shahid Beheshti Hospital, Babol, Iran
Background and aims.– The purpose of this research was to inves-

tigate correlation between cultural personality with social health
and psychological hardiness in married staff people.
E-PP0341 Results.– The prevalence of depression was twenty five (25%) per-
Relevance of spect in differential cent. Most of the respondents have moderate (10.8%), borderline
diagnosis between dementia and (9.3%), severe (3.4%) and extreme (1.5%) levels of depression. Major-
ity were male, single, finished tertiary education, employed, lives
depression. A case report in urban centers, without family history of depression, without
H. De La Red Gallego* , A. Alonso Sánchez, A. Álvarez Astorga, C.
partners, more than 200 CD4 counts, without comorbid illnesses,
Noval Canga, L. Rodríguez Andrés, M. De Lorenzo Calzón, N. De
non-drug users, receives antiretroviral regimen, one to five years
Uribe Viloria, M. Gómez García, E.M. Rodríguez Vázquez, C.M.
duration, without adverse drug interactions. The age group of nine-
Capella Meseguer, A. Pérez Escudero, F. De Uribe Ladrón de
teen to twenty nine (19–29 years old), level of CD4 counts and
Cegama
recipient of antiretroviral therapy were significantly associated
Hospital Clínico Universitario de Valladolid, Psychiatry, Valladolid,
with the level of depression.
Spain
Conclusions.– The high prevalence of depression among human
immune deficiency virus patient was a great challenge for clinicians
Background and aims.– Regarding to dementia and depression, the to accurately diagnose and effectively identify patients who were
possibility of comorbidity and overlapping symptoms complicate at risk of developing depression. Early screening and detection of
the differential diagnosis. 25% of patients diagnosed with mild cog- depression improves patient’s health and well-being.
nitive impairment suffer from depression, a prevalence that can Disclosure of interest.– The authors have not supplied a conflict of
increase up to 65% in dementia. Moreover, about half patients with interest statement.
late-onset depression suffer from cognitive impairment.
Methods.– A 74-year-old male admitted to a psychiatric unit due to
E-PP0343
a major depressive episode with psychotic symptoms since three
weeks ago. During admission, progressive cognitive deterioration The direct and longitudinal impact of
was observed. the receptive composite montage in
Results.– Blood test including folic acid level, vitamin B12, hepatitis, treating depression: a new music
HIV and lues without alterations. Brain MRI: chronic changes due to therapy in psychiatry
atrophy and microangiopathy. The neuropsychological evaluation L. Delpech1* , D. Deplante2 , J.L. Sudres1
suggests severe cognitive deterioration. SPECT HMPAO: moderate- 1 Université de Toulouse Jean Jaurès, Psychologie, Toulouse, France; 2
severe hypoperfusion in both temporal and parietal lobes, with Université de Toulouse Jean Jaurès, Musicology, Toulouse, France
greater involvement of the left side, and moderate hypoactivity in * Corresponding author.
the occipital lobe, suggesting Alzheimer’s disease (AD). No perfu-
sion alterations in other locations. He was diagnosed with major Background and aims.– The RCM is a new receptive music ther-
depressive disorder and probable AD. apy technique associating both the traditional and the institutional
Conclusions.– Studies propose that late- onset depressive symp- techniques. It consists in an ensemble made of six pieces of music
toms can be a risk factor or prodrome of AD. SPECT allows early divided into 3 phases, each one bearing two aspects: one is objec-
distinction of different hypoperfusion patterns in dementia and tive and aims to bring the patient to a relaxed state, and the other is
depression that can be useful as an auxiliary tool in differential subjective and leads to a positive mood (A phase: stimulating and
diagnosis, added to exhaustive clinical assessment and neuropsy- negative; B phase: relaxing and neutral; C phase: awakening and
chological evaluation. Amen, Krishnamani et al. differentiated positive mood).
patients with depression and comorbid dementia from patients The aims of this research are (1) to demonstrate the RCM validity
with a single diagnosis with 83% accuracy. by verifying its expected direct effects. (2) to demonstrate the RCM
Disclosure of interest.– The authors have not supplied a conflict of impact on depression in the medium term.
interest statement. Methods.– 23 patients in Psychiatric Hospital participated in this
study, 10 of whom in the control group (61,53% woman; aver-
age age = 52 + 12). The expected direct effects are measured with
E-PP0342 an oximeter, and interviews. The depression progress is estimated
Depression among human through Beck’s depression inventory.
immunedeficiency virus patients in Results.– The heartbeats decrease during the B phase and then
increase during the C phase (F = 14.64, p < .001; F = 79.07, p = < .001).
Corazon Locsin Montelibano
The interviews report a mostly negative mood (84%) before the ses-
Memorial Regional Hospital sions versus a mainly positive mood afterward (88%). Furthermore,
W. Dela Cruz MPM-HSD, M.J. Gayares the group having attended the therapy shows depression scores
1 Corazon Locsin Montelibano Memorial Regional Hospital, Internal
lower than they were at the start, and smaller than the control
Medicine, Bacolod City, Philippines group’s progress (z = .003; z = .012 respectively).
Conclusions.– The RCM elicits a relaxed state and a positive mood
Background and aims.– Depression is the most common neuropsy- without medication. Moreover, the ones who received the ther-
chiatric complication among Human Immune Deficiency Virus apy in the medium-term are less pathological than the others. This
patients that occurs in all phases of the disease. It affects the quality study shows the advantages of using the RCM in psychiatry.
of life, increasing disease progression and mortality. Disclosure of interest.– The authors have not supplied a conflict of
Objectives.– This study aims to determine the prevalence of depres- interest statement.
sion and it significant association among demographic and clinical
profile of patients.
Methods.– Two hundred four respondents (n = 204) were randomly
selected at the treatment hub with a prospective-descriptive cross
sectional study design. A validated Beck Depression Inventory was
administered during the study. The results were analyze using sta-
tistical package for social sciences, multivariate logistic regression,
chi square and odds ratio for association.
E-PP0344 Results.– The results show that drivers are a particularly risky popu-
RAT amygdala based altered miRNA lation. Their working conditions were difficult. During 3 years ago,
transcriptomics and role of 22.75% of drivers report having two accidents, 15.75% have had
one accident. On the other hand, stress was assessed using the
MIR-128-3P IN developing depression Perceived Stress Scale (PSS) which indicated that 38.75% of pro-
phenotype via WNT signaling fessional drivers suffer from regular stress, compared to 26% of
Y. Dwivedi non-professional drivers (p = 0.026). Moreover, the evaluation of
UAB, Department of Psychiatry and Behavioral Neurobiology, the psychic state of the subjects, mentioned that 23.75% of the
Birmingham, USA professional drivers present anxio-depressive disorders (HADS),
against 18% of the non-professional drivers (p = 0.000).
Conclusions.– This work was able to highlight the altered neu-
Background and aims.– As epigenetic modifier, microRNAs (miR-
ropsychological disorders specific to the occupation of professional
NAs) present novel regulators of gene expression in brain. Recent
drivers. All this is in order to promote road safety and reduce the
studies suggest that miRNAs can participate in depression patho-
production of road accidents.
genesis by altering a host of genes that are critical in neurobiology
of cortico-limbic functioning. Amygdala is part of the limbic sys-
interest statement.
tem involved in memory modulation, fear and stress response, as
well as emotional learning. The present study focused on examining
whether alterations in miRNA network in amygdala is associated E-PP0346
with susceptibility (learned helplessness: LH) or resiliency (non-
learned helplessness: NLH) to develop depression in rodents.
Pharmacological interventions for
Methods.– miRNA-specific next generation sequencing was used prevention of depression: systematic
to identify dysregulated miRNA transcriptomics across LH and review and meta-analysis
NLH, groups. Bioinformatic tools were applied to understand the S. Farooq1* , S. Singh2 , D. Burke3 , F. Naeem4 , M. Ayub5
1 Keele University, Faculty of Health Sciences, Keele, Staffordshire,
target gene set enrichment and altered pathways resulting from
overall miRNA dysregulation. Furthermore, miRNA-specific target United Kingdom; 2 Consultant Psychiatrist, Black Country NHS
interaction was determined using in-vitro transfection assay in Partnership Trust, Wolverhampton, UK and University of
neuroblastoma cell line. Wolverhampton, Wolverhampton, UK, Mental Health,
Results.– Group-wise comparison identified 17 significantly upreg- Wolverhampton, United Kingdom; 3 Research Institute for Primary
ulated and 8 downregulated miRNAs in LH compared to NLH group. Care & Health Sciences Keele University, UK, Centre for Prognosis
Target prediction analysis showed that a majority of upregulated Research, Keele Staffordshire, United Kingdom; 4 Centre for Addiction
miRNAs had target genes enriched for Wnt signaling pathway. & Mental Health, Mental Health, Toronto, Canada; 5 Queens
Amygdala-specific in-vivo target expression analysis also showed University, Department of Psychiatry, Ontario, Canada
significant downregulated Wnt signaling genes including Wnt3,
Wnt3a, Wnt5a, Wnt9b, Dvl1 and Lef1 in LH compared with NLH
or control rats. In-vitro transfection assay using the most signifi- Background and aims.– Depressive disorders account for about of all
cantly upregulated miR-128-3p demonstrated marked decrease in Disability Adjusted Life Years caused by psychiatric disorders. We
the expression of Dvl1 and Lef1 from Wnt signaling pathway. aimed to assess efficacy of pharmacological treatments in preven-
Conclusions.– Altogether, our study suggests that miRNAs may play tion of depression
an important role in depression susceptibility, which could be Methods.– We searched PubMed, Psych Info, EMBASE, and CINHAL
mediated through disruption in Wnt signaling pathway. from 1980 to September 2018 and bibliographies of relevant sys-
Disclosure of interest.– The authors have not supplied a conflict of tematic reviews. Randomised controlled trials (RCTs) that used a
interest statement. pharmacological intervention to prevent the onset of new depres-
sive episode in adult population were selected. Study selection, data
extraction and reporting is done following PRISMA guidelines. Data
E-PP0345 were pooled using random-effects meta-analysis
Results.– 27 trials included 2493 non-depressed participants at
Stress, anxiety and depressive
baseline. Prophylactic antidepressants (22/27 studies), Selenium,
disorders among a sample of small Hormone Replacement Therapy and Omega-3 fatty acids were used
taxi drivers in Morocco to prevent depression, mostly in physical conditions associated
I. Echarbaoui* , I. Cherkaoui El-Malki, A.O.T. Ahami with high risk of depression. All pharmacological interventions
Faculty of Science, University Ibn Tofail, Unit of Neuroscience and [pooled Odds Ratios (OR) 0.35; 95% CI 0.23, 0.50] and antidepres-
Applied Nutrition, Laboratory of Nutrition, Health and Environment, sants (OR 0.29; 95% CI: 0.17, 0.50) were significantly more effective
Department of Biology, Kenitra, Morocco than placebo in preventing depression. Drug treatment was signif-
icantly better in preventing post stroke depression (OR = 0.16, 95%
CI: 0.05, 0.55), depression associated with Hepatitis C (OR = 0.51
95% CI: 0.31, 1.02), head and neck cancer (OR 0.30;95% CI 0.13, 0.69),
Background.– Occupational stress is a major public health problem
postnatal depression (OR = 0.59;95% CI: 0.33, 1.04), traumatic brain
in the world. The stressed individual is likely to somatize neuropsy-
injury OR = 0.26 (95% CI: 0.08, 0.84) and acute coronary syndrome
chological problems such as anxiety and depression. Moreover, the
OR = 0.18 (95% CI 0.04, 0.86).
impact of stress on road safety can also be road accidents that are
Conclusions.– This is first meta analysis of all pharmacological inter-
now a major social problem in Morocco.
vention used in depression prevention. Despite the limitations of
Objective.– The aim focuses on the description of the level of stress
of the short follow up period in most trials, prophylactic antide-
in drivers, related to psychological suffering of anxious-depressive
pressants may be useful for preventing depression in high-risk
type, as factors generating road accidents.
conditions such as stroke.
Methods.– The study is transversal, with descriptive and analytical
aims. It involved 200 drivers in Kenitra, Morocco. It conducted using
interest statement.
a questionnaire assessing the characteristics of the subjects, the
Perceived Stress Scale (PSS) and Hospital Anxiety and Depression
scale (HADS).
E-PP0347 or Malay version Montgomery-Asberg Depression Scale-Self. Func-

Alexithymia and cognition in patients tional status was assessed using Modified Barthel Index (MBI)
with depression: a cross sectional Results.– A total of 65.4% of patients had good positive emotion and
23.5% of patients had depression. Patients with length of stay less
study than 5 days were 7.3 times more likely to have good positive emo-
A. Faye1* , R. Tadke2 , D. Singh2 , S. Gawande2 , V. Kirpekar2 , S.
tion and 12.3 times less likely to have depression. Patients with
Bhave2
1 NKPSIMS & Lata Mangeshkar Hospital, Department of Psychiatry,
less than 3 medical co-morbidities were 4.3 times less likely to
have depression. Total PERS and MADRS-S scores were significantly
Nagpur, India; 2 NKPSIMS & Lata Mangeshkar Hospital, Psychiatry,
associated with functional independence and functional recov-
Nagpur, India
ery. However, using multiple linear regression, only total PERS,
was significantly associated with both functional independence
Background and aims.– and functional recovery. Other factors that significantly associated
Introduction.– Depression is known to cause impairment in individ- with post-stroke function were the length of stay, MBI (discharge),
uals’ emotions & cognitive abilities. Alexithymia can be a feature spouse and age.
associated with depression. Cognitive symptoms like impairment Conclusions.– Positive emotion is a stronger predictor of functional
in concentration, memory and executive functions are commonly independence and function recovery compared to post-stroke
present in depression and correlated with its severity. depression. Other predictors of functional outcome were length of
Objectives.– To find the relation between alexithymia and cognitive stay, MBI at discharge, married status and age.
function in patients with depression. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– A cross sectional study was conducted on 70 patients interest statement.
of major depressive disorder (MDD) attending the Psychiatry
Out Patient Department of tertiary care hospital. Participants
were selected consecutively and assessed with semi-structured E-Poster Presentation: Depression - Part III
proforma, Hamilton Depression Rating Scale (HAM-D), Toronto
Alexithymia Scale (TAS-20) and Montreal Cognitive Assessment
(MOCA). Data collected was tabulated and analysed statistically
using mean, standard deviation, chi square test and spearman cor- E-PP0349
relation test. Impact on clinical evolution and
Results.– Mean age of participants was 37.86years and mean quality of life of comorbid
duration of MDD 3.3years. 30% of the participants were newly diabetes-depression. do we need to
diagnosed, 42.85% were in partial remission, 18.57% in complete
improve detection in primary care?
remission whereas very few were resistant and relapse cases. Anx-
G. Heinze* , N. Bernard, D.P. Guízar
iety (45.71%) and somatic symptoms (27.14%) were commonest
National University of Mexico, Faculty of Medicine, Mexico City,
comorbidities. 47.14% had mild MDD and 25.71% were in moderate
Mexico
severity range. 67.14% of the participants had alexithymia (mean * Corresponding author.
score 69.81) whereas 20% had ‘possible alexithymia’ (mean score
56.57). Those with high HAM-D score also had higher score on alex- Background and aims.– Major Depressive Disorder (MDD) and dia-
ithymia. Negative correlation was found between score of HAM-D betes mellitus (DM) have been recognized as worldwide major
and alexithymia with the score on MOCA. public health issues; however, in Mexico no studies to date exam-
Conclusions.– More than 2/3rd patients had alexithymia, corre- ined the impact on clinical evolution and quality of life.
lating positively with the severity of MDD. Patients with severe To assess the prevalence of undiagnosed MDD in patients with DM2
depression and higher score on alexithymia had more cognitive and to compare clinical evolution and quality of life in patients with
impairment (less score on MOCA). and without current MDD.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Comparative longitudinal study coordinated by UNAM
interest statement. and INTERPRET-DD. 137 DM2 patients (mean age 53.3 ± 8.21 years)
were evaluated by using the MINI (Mini International Neuropsychi-
atric Interview), Problem Areas in Diabetes Questionnaire (PAID),
E-PP0348 Well-Being Index (WHO-5) and Patient Health Questionnaire (PHQ-
Association between positive 9) and a brief medical history about socio-demographic data,
emotions, depression and functional lifestyle factors and clinical characteristics.
recovery in post-stroke patients Results.– Of the total sample, 27% (n = 37) had depression (25
J.S. Gill1* , J.S. Low2 , A. Kaur1 women, mean age 52.0 ± 7.1 years). WHO-5 showed a lower mean
1 University Malaya, Psychological medicine, Kuala Lumpur, for patients with vs without depression (14.2 ± 6.6 vs 23.3 ± 2.4,
Malaysia; 2 Penang Hospital, Psychiatry, Penangm, Malaysia p < 0.001). PAID showed a greater uncomfortableness in depressed
* Corresponding author. patients (15.8 ± 12.6 vs 5.4 ± 7.8, p < 0.001) and PHQ-9 showed a
greater symptomatology in depressed patients (10 ± 5.5 vs 1.9 ± 3).
Background and aims.– Stroke is a major health problem in Malaysia Patients with MDD presented more complications (1.43 ± 1.16 vs
which leads to substantial disease burden to the country. Post- 0.98 ± 1, p = 0.01): neuropathy (61% vs 37%) and retinopathy (43.9%
stroke depression was well studied in association with functional vs 17%).
outcome. However, there was no study on positive emotion in post- Conclusions.– Patients with comorbid DM2-Depression showed a
stroke patients in local setting. The objective of this study is to greater number of complications (neuropathy/retinopathy), which
assess positive emotion and depression in post-stroke patients in represent an impact on quality of life. These findings support a
Hospital Pulau Pinang and their association with functional recov- recommendation for routine screening and management of comor-
ery. bidity, especially for those in primary care, in order to reduce the
Methods.– A total of 136 patients at 6–12 weeks post stroke, number of non-recognized depressed diabetic patients, improve
were recruited, and assessed with Positive Emotion Rating Scale treatment adherence, decrease the number of complications and
(PERS) and Montgomery-Asberg Depression Scale-Self (MADRS-S) improve quality of life.

interest statement.
E-PP0350
Psychiatrists’ satisfaction, attitudes
and opinions regarding current
antidepressants and outlook for the Figure 3. Agreement with Statements.
future: 2018 survey
S. Hess1,2* , A. Weizman3,4
1 Geha Mental Health Center, Closed Ward A, Petah Tikva, Israel; 2
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3

Felsenstein Medical Research Center, Petah Tikva, Israel; 4 Geha
Mental Health Center, Research Unit, Petah Tikva, Israel
Background and aims.– By 2030 it is expected for depression to be

the leading disability in high-income countries.1 In most cases cur-
rent treatments result only in partial symptomatic improvement2 .
Figure 4. Importance of Drepression Treatment Goals.
In the “real-world” as presented in the STAR*D study, response and
Conclusions.– Psychiatrists’ satisfaction with current anti-
remission rates were 47% and 28%, respectively.3 In two-thirds of
depressive treatments is only partial.
patients with depression significant functioning impairments per-
• Lowest level of satisfaction is regarding cognitive symptoms of
sists for at least 3 more months following initiation of treatment.4
depression.
The present study aims to investigate psychiatrists’ satisfaction,
• Main treatment objectives: mood improvement, symptomatic
attitudes and opinions regarding current antidepressants and out-
remission and return to full functioning.
look for the future.
• New psychopharmacological and psychotherapeutic treatments
Methods.– The data was collected via an internet survey distributed
that focus more on cognitive improvement and return to full
via the website of the Israel Psychiatric Association in January 2018.
functionality are needed for depression patients.
The satisfaction rating scale ranged from 1–10 with 1 = “completely
dissatisfied” and 10 = “completely satisfied”. The rating scale for
interest statement.
agreeing or disagreeing with the statements in the survey ran
from 1–10 with 1 = “completely disagreeing” and 10 = “completely
agreeing” and the same range was used for indicating the impor-
E-PP0351
tance attached to the anti-depressive treatment objectives with
1 = “completely unimportant” and 10 = “highly important”. Statis- Linguistic analysis of descriptions of
tical analysis was done using the 2 -test and the T/F-test (one-way naturally occurring events in
ANOVA). depressed individuals: a daily diary
Results.– Satisfaction, attitudes and opinions of the psychiatrists study comparing clinically depressed
who participated in the survey are presented below (Figs. 1–4).,
and healthy controls
P. Holas1* , N. Rohnka2 , I. Krejtz2 , M. Rusanowska3 , J. Nezlek4
1 University of Warsaw, Psychology, Warsaw, Poland; 2 University of
Social Sciences and Humanities, Psychology, Warsaw, Poland; 3 Polish
Academy of Sciences, Psychology, Warsaw, Poland; 4 University of
Social Sciences and Humanities, Psychology, Poznan, Poland
Background and aims.– Major Depressive Disorder (MDD) is a debili-

tating disorder and one of the most common psychiatric problems.
Figure 1. Summary of Satisfaction with Existing Treatments in the In order to advance treatment of depression, more research are
Different Dimensions. needed to understand its nature and facets. One of the valuable but
rarely used method of investigation of cognitive operations associ-
ated with depression is linguistic analysis of people writing style.
The aim of current study was to examine differences in descrip-
tion and perception of naturally occurring events in a sample of
clinically depressed and healthy individuals.
Methods.– 135 individuals with MDD and 138 nonclinical subjects
participated in the study. Each day for up to two weeks, partici-
pants provided brief descriptions of events that happened to them
on day in question, and rated each event in terms of its stress-
fulness and positivity. Descriptions of events were analysed using
computerised text analysis program, Linguistic Inquiry Word Count
(LIWC).
Results.– Multilevel analyses found that depressed individuals used
Figure 2. Distribution of Satisfaction by Workplace and Geographic more words related to negative emotions and less words describing
Region. positive emotions than healthy controls. Depressed referred more
to other people and to the past than controls, wrote less about fam-
ily and used more words reflected discrepancy. They also rated their
daily experiences as more stressful and less positive. Daily stress
was significantly related to events descriptions. Stressfulness of the Background and aims.– Depression is one of the most common
day was positively related to frequency of words related to self and mental disorders. Major Depressive Disorder (MDD) in accordance
negative emotions and was negatively related to positive emotions to the inflammatory concept is associated with immunologi-
and cognitive mechanisms. cal disturbances in the central nervous system. Recent studies
Conclusions.– These findings suggest that depressed people per- on neurodegenerative diseases have focused on the kynure-
ceive their naturally occurring daily events as more stressful and nine metabolism. Kynurenines are the products of tryptophan
less positive. metabolism. There are studies providing evidence for a role of
E-PP0352 aabnormalities of the kynurenine (KYN) pathway in the pathophys-
Changes of EEG coherence after the iology of depression. Nevertheless, an exact relationships between
course of combined antidepressive each metabolite of the KYN pathway and mood disorder remain
unclear. Dityrosine is clinical marker of oxidative stress, aging and
treatment included transcranial neurodegenerative diseases.
magnetic stimulaton The goal of this research project is to assess the role of oxidative
A. Iznak1* , E. Iznak1 , E. Damyanovich1 , I. Oleichik2 , T. Medvedeva3 modification products in pathophysiology of depression.
1 Mental Health Research Centre, Laboratory of Neurophysiology, Methods.– The study comprised of 21 patients with depression aged
Moscow, Russia; 2 Mental Health Research Centre, Department of 30–65 who were hospitalized in the Clinic of Psychiatry of Faculty of
Endogenous Mental Disorders and Affective Conditions, Moscow, Health Sciences, Medical University of Warsaw, Poland. Examined
Russia; 3 Mental Health Research Centre, Department of Medical group included people suffering from MDD. The mean duration of
Psychology, Moscow, Russia the episode was 2 weeks - 1year. Blood specimens were taken to
measure the levels of oxidative modification products: dityrosine,
kynurenine, N-formylkynurenine, and tryptophan.
Background and aims.– High-frequency transcranial magnetic stim-
Results.– Statistical analysis revealed significant correlations
ulation (TMS) of the left dorsolateral prefrontal cortex (DLPFC)
(Spearman’s rho, p < 0, 05) between kynurenine and dityrosine.
confirmed as non-invasive instrumental method for improvement
Therefore the present study shows the associations between N-
of clinical conditions and cognitive functions in depressive patients.
formylkynurenine and dityrosine (Spearman’s rho, p < 0, 05).
Nevertheless, post-treatment EEG changes observed in brain areas
Conclusions.– The results of the research may play an important role
beyond the site of TMS application, and in lower frequency EEG
in understanding the exact role of kynurenine pathway in patho-
bands.
physiology of depression. Research with response to treatment and
The aim of the study was the search of post-treatment EEG changes
oxidative stress associations with the kynurenine pathway taken
in the area of TMS application.
into account pose a promising target for future studies.
Methods.– Two groups of female depressive patients (age 18–49)
were studied. TMS group (n = 27) received combined treatment
included antidepressants and course of TMS (25 Hz) of left DLPFC. E-PP0354
Control group (n = 24) received only pharmacotherapy. Multichan-
nel EEG was recorded before and after course of treatment with
Depressive symptoms masking an
consequent spectral-coherent EEG analysis. amyotrphic lateral sclerosis: a case
Results.– After the treatment, improvement of clinical conditions report
(by HDRS-17) occurred in both groups, but the psychological W. Kabtni* , C. Bencheikh, R. Maamouri, A. Baatout, M.W. Krir, H. El
state (by SCL-90-R), as well as decision-making (in WCST and IGT Kefi, A. Oumaya
tests) appeared significantly better (p < 0.05) in TMS group. Post- Military Hospital, Psychiatry Department, Tunis, Tunisia
treatment EEG coherence in TMS group increased mainly in бetɑ2
(20–30 Hz) EEG sub-band between F7-F3 EEG leads (that is near the
site of TMS application), and accompanied by increase of beta2 EEG Background and aims.– Amyotrophic lateral sclerosis (ALS) is a neu-
spectral power (at tendency level). In control group EEG coherence rodegenerative disorder characterized by progressive loss of motor
increased in ɑльфɑ2 (9–11 Hz) and tetɑ1 (4–6 Hz) EEG sub-bands neurons, leading to physical impairment, sleep disturbance and
over frontal-central-temporal regions of both hemispheres and other symptoms which may confound the diagnosis with a depres-
inter-hemispherically. sive disorder.
Conclusions.– The data obtained suggested that activation of left This case report highlights the prevalence of depressive symptoms
DLPFC by high-frequency TMS in combined antidepressive treat- as inaugurating symptoms of ALS and identify diagnostic means to
ment improves mainly psychological conditions and cognitive avoid confusion.
functions, and reflected in changes of beta2 EEG coherence rather Methods.– We have used the medical file of a patient who consulted
than spectral power. the psychiatric department of the military hospital of Tunis.
Disclosure of interest.– The authors have not supplied a conflict of Results.– A 46-year-old military male, married and father of three
interest statement. children with medical history of diabetes and dyslipidemia and psy-
chiatric history of a depressive disorder treated 10 years ago. The
patient consulted for moodiness, severe asthenia and choppy sleep
E-PP0353 with an intermittent feeling of dyspnea.
A depressive relapse was the more likely diagnosis and the patient
Kynurenine pathway in depression
was put on an antidepressant and anxiolytic treatment.
M. Janoska-Jaździk1* , A. Zalewska2 , M. Maciejczyk3 , N.
One month later, the patient re-consulted for a slurred speech with
Waszkiewicz4 , A. Szulc1
1 Medical University of Warsaw, Faculty of Health Sciences, Clinic of a worsening of his asthenia which caused him difficulty of walking.
Thus, the patient was referred to the neurology consultation to
Psychiatry, Warsaw, Pruszków, Poland; 2 Medical University of
eliminate an organic cause.
Bialystok, Department of Restorative Dentistry, Bialystok, Poland; 3
The explorations discovered an amyotrophic lateral sclerosis.
Medical University of Bialystok, Department of Physiology, Bialystok,
Conclusions.– Depressive symptomatology may feature in the early
Poland; 4 Medical University of Bialystok, Department of Psychiatry,
stages of ALS because of many similar features. The use of the appro-
Bialystok, Poland
* Corresponding author. priate diagnostic means allows to detect pathologies masked by a
psychiatric chart.
interest statement.
E-PP0355 Results.– The evaluation of prevalence of DD showed the follow-

The role of inhibition in the link ing distribution: Absence of symptoms of depression was revealed
between daily repetitive negative in 65% (n = 466), separate symptoms - 18% (n = 128), mild DD
13% (n = 91), major DD 4% (n = 28). During comparison of distri-
thinking and daily mood bution of depressive symptoms in rural and urban areas there
M. Kornacka1,2* , C. Douilliez3 , P. Napieralski4 , I. Krejtz1
1
were no differences. Gender differences in the incidence of depres-
SWPS University of Social Sciences and Humanities, Faculty of
sion were observed in females and males (2:1) Mild and major
Psychology, Warsaw, Poland; 2 University of Lille, EA 4072 - PSITEC -
DD in women was higher - 23.76% (n = 82) than in men - 10.05%
Psychologie: Interactions Temps Émotions Cognition, Lille, France; 3
(n = −37), (p < 0.0001). This study included 368 men (51.62%), 345
Catholic University of Louvain, Faculty of Psychology and Educational
women (48.38%). At rank correlation of some items in the BDI, the
Sciences & Psychological & Sciences Research Institute,
most significant moderate associations (r > 0.6) were with cogni-
Louvain-La-Neuve, Belgium; 4 Lodz Technical University, Institute of
tive impairment with low self-esteem, feeling of worthlessness,
Information Technology, Łódź, Poland
anhedonia and anergy. Correlation coefficient varied from 0.63 to
0.66.
Background and aims.– Repetitive negative thinking (RNT) is a risk, Conclusions.– As a result of the investigation with use of the BDI
maintenance and recurrence factor in numerous psychological dis- probable differences in DD frequency in women and men and the
orders like depression, anxiety, addiction or eating disorders (for a main symptoms of depression with cognitive changes.
review see: Watkins, 2008). A recent literature suggests that one E-PP0357
of the factors responsible for RNT recurrence might be inhibition Features of psychosocial
impairment (Yang et al., 2017). maladaptation in women with
The aim of the present study was to verify whether inhibition depressive disorder depending on its
efficiency affects the causal link between daily RNT and mood in
etiology
remitted depressive patients and healthy controls. We examined
I. Leshchyna1* , R. Isakov2 , K. Zelenska1 , T. Kraskovska1
the relationships with the use ecological momentary assessment 1 Kharkiv National Medical University, Psychiatry, Narcology and
(EMA) methodology.
Medical Psychology, Kharkiv, Ukraine; 2 Ukrainian Medical
Methods.– 25 participants underwent a 7-day assessment via
Stomatological Academy, Psychiatry- Narcologyand Medical
mobile phone application (mood and RNT assessment 5 times a day,
Psychology, Poltava, Ukraine
inhibition assessment with Emotional Stroop Task, once a day). * Corresponding author.
Results.– The results show that remitted depressive patients
reported higher level of rumination comparing to healthy controls. Background and aims.– It is well-known that depressive disorders
However, the 3 level model in multilevel modeling (level 1– obser- affect the quality of social functioning. At the same time, the prob-
vations, level 2 - days, level 3–persons) did not support the results lem of psychosocial maladaptation, which is considered both as
from self-reported measures. It seems that in both groups daily predictor of the emergence of depression and as consequence of
RNT similarly predicts negative affect. Moreover, daily inhibition the disintegrating influence of the disease on adaptive mechanisms
efficiency of negative material strengthens the link between RNT and social connections, is particularly acute. Purpose: assessment
and daily mood. of psychosocial maladaptation in women with depressive disorders
Conclusions.– The present study disentangles the causal relation of different genesis.
between RNT and mood in daily life. The study provides also data Methods.– Clinico-psychopathological and psycho-diagnostic
on the role of inhibition in this relation. The results are promis- methods were used. 252 women with diagnosis of depressive dis-
ing in the perspective of executive functions training addressing order were examined: 94 persons with psychogenic depression, 83
maladaptive RNT. The study provides an important contribution to women with endogenous depression, 75 -with organic depressive
methodological concerns of comparing retrospective self-reports disorder.
to daily sampling measures, supporting their potential indepen- Results.– In order to identify and quantify the degree of psy-
dence. chosocial maladaptation, based on a comprehensive analysis
Disclosure of interest.– The authors have not supplied a conflict of of data on the peculiarities of functioning in various spheres,
interest statement. we have developed an original psycho-diagnostic scale that
allows us to distinguish and evaluate the key trends in psy-
chosocial maladaptation. The scale is suitable for use in clinical
E-PP0356 practice. The scale encompasses three main clusters of psychoso-
Prevalence of depression among cial functioning: macro-social (an assessment of socio-economic,
students of colleges in West Siberia socio-informational maladaptation); meso-social (an assessment
N. Kornetov* , A. Prikhodko of socio-professional, interpersonal maladaptation); micro-social
Siberian State Medical University, Department of Psychiatry, (assessment of family, parental maladaptation).
Narcology and Psychotherapy, Tomsk, Russia Conclusions.– Assessment of the state of psychosocial maladapta-
* Corresponding author. tion according to the data of the survey patients with depressive
disorders of psychogenic, endogenous, organic nature allowed to
Background and aims.– Depressive disorder (DD) is the most com- establish that the severity of maladaptation in all 6 areas in patients
mon and severe disease in adolescents. Objective was to study the with depression of organic genesis is the most difficult, endogenous
probable prevalence of DD among students of colleges. –average, and psychogenic–the easiest. The revealed patterns are
Methods.– One-time cross-sectional survey among students from important for the planning of psychoprophylaxis and psychocor-
11 colleges was carried out in Tomsk and the Tomsk Region. Total rective measures in patients with depressive disorders of various
number of respondents was 797, of whom 423–male, 374–female. genesis.
The clinical sample included students aged 15–19 years. Mean age Disclosure of interest.– The authors have not supplied a conflict of
was 17.38 ± 1.86. Beck Depression Inventory (BDI - version for ado- interest statement.
lescence) was used for measuring the symptoms of depression
and DD. For statistical processing rank correlation, х2 -criterion was
used.
E-PP0358 Results.– The main effects of diagnosis displayed abnormal GM vol-

The role of the sigma-1 receptor in the ume located in the left superior parietal lobule (MDD < HC) and
rapid antidepressant effect of right middle occipital gyrus (MDD > HC). While the left dorsolat-
eral prefrontal cortex (DLPFC) volume revealed a significant main
ayahuasca effect of childhood trauma, as shown by decreased GM volume of
M. Liester* , M. Liester
the left DLPFC in subjects with CTE, regardless of diagnosis. A nega-
University of Colorado School of Medicine, Psychiatry, Monument,
tive correlation was also found between the left DLPFC volume and
USA
emotion abuse in individuals reporting CTE.
Conclusions.– The present findings suggest that decreased GM vol-
Background and aims.– Ayahuasca is an Amazonian brew used by ume of the left DLPFC is a function of childhood trauma rather than
indigenous healers in South America. Recently, ayahuasca has been MDD, which may represent the risk for developing MDD.
demonstrated to exhibit rapid onset antidepressant (AD) effects. Disclosure of interest.– The authors have not supplied a conflict of
We set out to understand the mechanism responsible for the rapid interest statement.
antidepressant action of ayahuasca.
Methods.– We conducted a PubMed search using the terms
E-PP0360
“ayahuasca,” “depression,” “sigma-1 receptors,” and “brain derived
neurotrophic factor.” Articles selected for inclusion consisted Depression subtyping based on
of those studies that investigated the relationship between evolutionary psychiatry
ayahuasca, depression, sigma-1 receptors, and BDNF. S. Luoto1* , H. Karlsson2 , I. Krams3 , M.J. Rantala4
1 University of Auckland, School of Psychology, Auckland, New
Results.– Ayahuasca is a tea prepared by mixing Amazonian
plants rich in harmala alkaloids, which act as monoamine oxidase Zealand; 2 University of Turku, Department of Clinical Science, Turku,
inhibitors (MAOIs), and dimethyltryptamine (DMT). Ayahuasca Finland; 3 University of Tartu, Institute of Ecology and Earth Sciences,
exhibits rapid (i.e. 1–2 days) antidepressant effects. Ayahuasca Tartu, Estonia; 4 University of Turku, Department of Biology, Turku,
binds to SIGMAR1, which increases the production of BDNF. Finland
Increased BDNF is associated with improvement in depression.
Other medicines that exhibit a rapid AD response (e.g. ketamine
and dextromethorphan) also act as ligands at SIGMA1R, indicating Background and aims.– Major depressive disorder is not a unitary
this protein may play a key role in the rapid AD response of multiple disease—it is a heterogeneous syndrome, with patients differing
medications. remarkably in symptom profile, pathophysiology and treatment
Conclusions.– We suggest ayahuasca’s rapid AD response is medi- responsiveness. Previous attempts to subtype major depressive dis-
ated by epigenetic up-regulation of brain-derived neurotrophic order have showed limited clinical applicability. We seek to present
factor (BDNF) resulting from modulation of sigma-1 receptors (SIG- a classification of major depressive disorder episodes based on the
MAR1). Understanding the rapid AD response to ayahuasca and proximate mechanisms that led to the original mood change that
other medicines may provide clues that will help in the develop- caused the depressive episode.
ment of other rapidly acting antidepressant medicines. Methods.– We reviewed existing research on depression and inte-
Disclosure of interest.– The authors have not supplied a conflict of grated it with evolutionary psychiatry.
interest statement. Results.– The review identified discrete depression subtypes that
are induced by: (1) infection, (2) long-term stress, (3) loneliness,
(4) traumatic experience, (5) hierarchy conflict, (6) grief, (7) roman-
E-PP0359 tic rejection, (8) postpartum events, (9) the season, (10) chemicals,
(11) somatic diseases and (12) starvation. Examining the ultimate
The left dorsolateral prefrontal cortex
functions of these subtypes shows that not all types of mood
volume is reduced in adults reporting changes that trigger depression are adaptive. Instead, some are
childhood trauma independent of clearly maladaptive and some are byproducts of other adaptations.
depression diagnosis Conclusions.– In modern societies, low mood after adverse life
S. Lu1* , W. Gao2 , Y. Xu1 , L. Li3 events may turn into a pathological depressive state. Modern
1 The First Affiliated Hospital, Zhejiang University School of Medicine, lifestyle increases susceptibility to inflammatory dysregulation and
Psychiatry, Hangzhou, China; 2 The Children’s Hospital, Zhejiang chronic stress, both of which increase the amount of proinflam-
University School of Medicine, Child Psychology, Hangzhou, China; 3 matory cytokines in peripheral blood, leading to low mood and
Mental Health Institute of The Second Xiangya Hospital, Central sickness behaviour. Proinflammatory cytokines may aggravate the
South University, Psychiatry, Changsha, China previously adaptive short-term mood changes to a chronic mal-
* Corresponding author. adaptive depressive state by preventing the normalization of mood
after adverse life events. Subtyping depression enables an effective
Background and aims.– Both major depressive disorder (MDD) and and intelligent long-term treatment of patients in each subtype by
childhood trauma have been linked with brain structural changes. treating the underlying causes of depression.
As childhood trauma is more highly prevalent in MDD patients, pre- Disclosure of interest.– The authors have not supplied a conflict of
vious morphometric findings in MDD therefore might have been interest statement.
confounded by childhood trauma. This study aimed to differen-
tiate the impact of childhood trauma from the influence of MDD
diagnosis on gray matter (GM) volume. E-PP0361
Methods.– Seventy-eight subjects were recruited into four study An innovative approach to evaluating
groups (n = 16, MDD patients with childhood trauma exposures,
CTE/MDD; n = 14, MDD patients without CTE, non-CTE/MDD; n = 24,
the ‘disease factors’ in the
healthy controls with CTE, CTE/HC; and n = 24, HCs without CTE, management of
non-CTE/HC). All participants underwent high-resolution struc- ‘treatment-resistance’ (TR) in mood
tural magnetic resonance scans. Voxel-based morphometry was disorder in older adults (MDOA)
used to investigate GM alterations, and a 2 × 2 analysis of variance A.S. Luthra1* , T. Semplonius2 , H. Millman3 , S. Remers4
was performed to identify the main effects of diagnosis, childhood 1 McMaster University, Behavioural Neuroscience, Hamilton, Canada;
trauma, and their interactions. 2 McGill University, Medicine, Montreal, Canada; 3 Homewood
Health Centre, Program for Older Adults, Guelph, Canada; 4 on admission, 6 of whom normalized by discharge. 2 additional
Homewood Health Centre, Research and Outcomes, Guelph, Canada patients achieved partial remission.
* Corresponding author. Conclusions.– MMSE is not an effective tool to capture cogni-
tive deficits in MDOA. MoCA is an effective tool both to screen
Background and aims.– Literature identifies a multitude of factors for deficits, and to monitor change in cognitive function with
contributing to ‘treatment-resistance’ in MDOA. We developed an treatment. Among the patients who showed impairment at admis-
approach in the Program for Older Adults (POA) at Homewood sion, 36% normalized in their scores. The rest showed significant
Health Centre (Guelph, Canada) to elucidate the heterogeneity of improvement in the scores, averaging at 23. This innovative
the ‘index episodes’ and their relevance in treatment resistance. approach to treating MDOA offers added benefits to the existing
Preliminary results of the application of this innovation are being evaluative paradigm.
presented in order to validate this approach. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– Patients were evaluated 3 times/week. To evaluate the interest statement.
‘disease factors,’ for the first 3–4 weeks the signs and symptoms
of each index episode were collected at the end of each week, and
grouped as emotional, cognitive, intellectual or physical. Pharma- E-PP0363
cological treatment was tailored to the phenotypic presentation Peculiarities of diagnostics and
of the illness during each week for an average of 12–14 weeks.
detection of depression by general
Each patient was administered the ‘Residents Assessment Inven-
tory’ at the time of admission and at discharge. All patients were practice doctors
also administered the long version of ‘Geriatric Depression Scale’ S. Magzumova* , R. Userbayeva
1 Tashkent Medical Academy, Psychiatry and Narcology, Tashkent,
(GDS) on admission and at discharge to demonstrate response to
treatment. Uzbekistan
Results.– 136 patients were admitted between the years
2012–2015. 63.2% achieved full remission and 30.9% achieved
Background and aims.– To study the features of diagnosis and detec-
partial remission. 4.4% of the patients did not show any response,
tion of depressive disorders in general medical practice.
and 2 patients (1.5%) got worse.
Methods.– 220 patients were examined - 110 men and 110 women
Conclusions.– Over 95% of the patients admitted to POA with a
aged from 30 to 60 years. Patients were tested by Hamilton to assess
diagnosis of MDOA responded to the pharmacological treatments
the depressive state. Patients were interviewed by the method of
designed through the application of this innovative approach to
rapid questionnaire to identify depression. Examination and eval-
evaluation, and the collection of signs and symptoms resulted in
uation of the effectiveness of treatment were carried out on an
very precise diagnosis. This method of evaluation of major men-
outpatient basis, and all patients underwent general somatic and
tal disorders may offer an alternative to the existing approach for
neurological studies. Criteria for inclusion in the survey: patients
teaching medical learners.
about their health status.
Results.– As a result of hypodiagnosis, only 12% of patients received
interest statement.
the necessary specialized care. 61% of patients with depression
focused on somatic complaints. Among elderly patients who go to
the clinic, patients with depression account for about 23%. 37% of
E-PP0362
them are determined by serious somatic pathology, which leads
Cognitive deficits in mood disorder in them to depression. Analysis of all cases studied shows that depres-
older adults (MDOA): state or trait sive disorders occur in 30% of cases.
phenomena Conclusions.– The lack of diagnosis of depressive disorders by
A.S. Luthra1* , T. Semplonius2 , H. Millman3 , S. Remers4 general practitioners has been determined. Hypodiagnosis occurs
1 McMaster University, Behavioural Neuroscience, Hamilton, Canada; much more frequently, the main cause of which is the peculiarities
2 McGill University, Medicine, Montreal, Canada; 3 Homewood of the clinical picture of depression, manifested in the prevalence
Health Centre, Program for Older Adults, Guelph, Canada; 4 of somatization symptoms, autonomic manifestations, sleep disor-
Homewood Health Centre, Research and Outcomes, Guelph, Canada ders and appetite. It should be emphasized that the identification
* Corresponding author. and qualification of depression in the conditions of general prac-
tice are fraught with considerable difficulties. Only 12% of patients
Background and aims.– Studies suggest the persistence of cognitive received the necessary specialized care.
deficits even after the full remission of depressive symptoms, but Disclosure of interest.– The authors have not supplied a conflict of
most use intricate neuropsychological measures to establish this interest statement.
relationship. We present data on the use of standardized screen-
ing tools (Mini-Mental State Examination- MMSE, and Montreal
Cognitive Assessment- MoCA) used with patients in the Program E-PP0364
for Older Adults, Homewood Health Centre, Guelph, ON, in order Stimulation of neurogenesis in the
to establish the applicability of these scales in everyday clinical
hippocampus in depressive-like
practice.
Methods.– Patients were evaluated through the Resident Assess- animals by modulated immune cells
ment Inventory (RAI) on admission and at discharge, to establish E. Markova1* , M. Knyazheva1 , T. Amstislavskaya2 , M. Tichonova2
1 Research Institute of Fundamental and Clinical Immunology,
change in their clinical condition. In addition, each patient was sub-
jected to the MMSE and MoCA on admission and at discharge, to Neuroimmunology Lab., Novosibirsk, Russia; 2 Research Institute of
elicit a change in scores. The treatment intervention applied this Physiology and Fundamental Medicine, Laboratory of Experimental
innovative approach to tailoring pharmacological treatment for Models of Neurodegenerative Processes, Novosibirsk, Russia
‘index episodes.’
Results.– Out of 126 patients admitted to the program between
Background and aims.– Depression is a devastating and prevalent
2012–2015, 75 showed cognitive impairment on the MoCA, and
disease, with profound effects on neural structure and function. The
27 of these normalized at the time of discharge. 45 achieved partial
potential role of neurogenesis, both its decline with the occurrence
remission. On the MMSE, 11 patients showed cognitive impairment
of depression and its enhancement by therapies, has provided a
promising avenue for research; significant findings have been made (striatum, hippocampus) and IL-10 increase in hippocampus and
relating neurogenesis to the effective treatment of depression. hypothalamus.
We first demonstrated that in vitro caffeine-modulated immune Conclusions.– Thus, M2-macrophages soluble factors, affecting the
cells after the transplantation eliminated cognitive and immuno- main pathogenetic mechanisms of depression, have a positive psy-
logical impairment in depressive-like recipients. The aim of this choneuromodulating effect. So, M2 cell based immunotherapy may
study was to investigate neurogenesis in the hippocampus in be a new approach to the treatment of depressive disorders.
depressive-like recipients after the caffeine-modulated immune Disclosure of interest.– The authors have not supplied a conflict of
cells transplantation. interest statement.
Methods.– (CBA × C57Bl/6) F1 depressive-like male mice, developed
under the long-term social stress, were undergoing the transplan-
tation of syngeneic immune cells in vitro treated with caffeine. The
histological picture of the hippocampal nuclei in recipient’s brain E-Poster Presentation: Depression - Part IV
was studied.
Results.– In depressive disorders is decreasing the volume of the
hippocampus, due to a decrease in the density of pyramidal neu- E-PP0366
rons in the CA1 and CA3 fields. Neurons apoptosis in these zones The protective effect of
is considered one of the pathogenetic mechanism of cognitive
self-compassion on the impact of
impairment in depression. We found that after the transplanta-
tion of in vitro caffeine-modulated immune cells in the brain of early shame and safeness memories
depressive-like mice the number of neurons in the CA1, CA3 fields on later depressive symptoms and
in the right and left hippocampus was significantly increased. safe affect
Conclusions.– Results demonstrated that immune cells with M. Matos1* , S. Steindl2 , A. Creed2
caffeine-modulated functional activity caused stimulation of neu- 1 Center for Research in Neuropsychology and Cognitive and
rogenesis in the hippocampus in depressive-like recipients. This is Behavioural Interventions CINEICC, University of Coimbra, Faculty of
experimental evidence of the promise of depression immunother- Psychology and Educational Sciences, Coimbra, Portugal; 2 University
apy by autologous immune cells with modulated in vitro functional of Queensland, Compassionate Mind Research Group, School of
activity. Psychology, Brisbane, Australia
Disclosure of interest.– The authors have not supplied a conflict of * Corresponding author.
interest statement.
Background and aims.– Psychological interventions that aim to pro-
mote compassion have gathered support for their effectiveness
E-PP0365 in the treatment of psychopathology. Compassion focused ther-
New experimental approach to apy (CFT), in particular, is a promising treatment for depression,
especially for patients presenting high levels shame. CFT works to
immunotherapy of depression based cultivate compassion competencies and reduce fears of compas-
on M2-macrophages sion, to promote mental health and positive affect, and alleviate
E. Markova1* , C. Shevela2 , A. Ostanin2 , M. Knyazheva1 , I. Savkin1 , distress.
E. Chernykh2 Although there is empirical support for the association between
1 Research Institute of Fundamental and Clinical Immunology,
fears of compassion, early emotional memories and depression, this
Neuroimmunology Lab., Novosibirsk, Russia; 2 Research Institute of study aims to explore the protective role of compassion competen-
Fundamental and Clinical Immunology, Cellular Immunotherapy cies in these associations.
Lab., Novosibirsk, Russia Methods.– 223 participants recruited from the general popula-
tion completed self-report questionnaires measuring traumatic
qualities and centrality of shame memories, early memories of
Background and aims.– The involvement of immune mechanisms
warmth and safeness, compassion for others, from others and self-
in the development and maintenance of neuro-inflammation is
compassion, and depressive symptoms and safe affect.
an essential link in the pathogenesis of depressive disorders.
Results.– Results revealed that shame memories’ traumatic qual-
Macrophages have high plasticity and are able to control the inflam-
ities and centrality to identity were positively correlated with
matory response. M2 anti-inflammatory cells have a pronounced
depressive symptoms and negatively with safe affect, compas-
regenerative potential due to the production of the complex of
sion from others and self-compassion, while early memories of
soluble mediators and cytokines, including neurotrophic, proan-
warmth and safeness were negatively correlated with depressive
giogenic and immunoregulatory factors.
symptoms and positively with safe affect and self-compassion.
The aim of this study was to investigate effect of M2 cells con-
Self-compassion had the strongest correlations with depressive
ditioned medium on behavioral phenotypes and brain cytokine
symptoms and safe affect. Path analysis revealed self-compassion
synthesis in depressive-like animals.
as the only significant mediator on associations between early emo-
Methods.– M2 macrophages were generated by culturing an adher-
tional memories, depressive symptoms and safe affect.
ent fraction of mononuclear cells with 50 ng/ml recombinant
Conclusions.– Targeting shame memories directly is important,
human GM-CSF in serum deprivation conditions for 7 days.
however the current study supports the added benefit of devel-
(CBA × C57Bl/6) F1 depressive-like male mice, developed under the
oping compassion competencies, and therefore developing the
long-term social stress, were undergoing the M2 cells conditioned
compassionate self, to reduce depressive symptoms and enhance
medium intranasal administration (60 ml twice daily for one ani-
safe positive affect.
mal) for 6 days. Behavioral phenotyping was carried out using an
automatic registration system (Noldus Information Technology).
interest statement.
Cytokines were determined by ELISA.
Results.– Depressive-like mice behavioral phenotyping after
immunotherapy with M2 cells conditioned medium revealed stim-
ulation of motor activity in open field and forced swimming tests,
anxiety reduction in elevated plus maze. Behavioral changes were
recorded against the decline of pathogenetically significant pro-
inflammatory cytokines (TNF-␣, IL-1␤, IL- 6, INF␥) in brain regions
E-PP0367 Methods.– A prospective cohort study was conducted on 105

Resilience and cognitive biases patients with depression who were sub-grouped depending on
mediate the relationship between severity of depression and presence of somatic syndrome. At base-
line, the severity of depression (MADRS), serum NGF, NT-3 and NT-4
early exposure to traumatic life events were estimated. Thirty-five healthy volunteers were recruited as
and depressive symptoms in young controls for a baseline comparison of neurotrophins. All patients
adults were followed up after 6 weeks, to evaluate the changes in neu-
˛ 1* , A. Arciszewska1 , A. Daren1 , A. Cechnicki1 , D.
D. Metel rotrophin levels and correlate it with the change in MADRS scores.
Frydecka2 , Ł. Gaweda
˛ 3 Results.– At baseline, neurotrophin levels were significantly lower
1 Jagiellonian University Medical College, Community Psychiatry in patients with depression in comparison to healthy control. In
Department, Krakow, Poland; 2 Wroclaw Medical University, group I, serum NGF, NT-3 and NT-4 level were found to increase
Department of Psychiatry, Wroclaw, Poland; 3 Medical University of significantly after treatment whereas changes in group II and III
Warsaw, II Department of Psychiatry, Warsaw, Poland were statistically not significant. MADRS score and serum NGF at
* Corresponding author. baseline had an inverse relation (r = −0.648) whereas the change in
MADRS score had a positive correlation (r = 0.563) with the change
Background and aims.– In recent years prevalence of depression of serum NGF.
in young adults has increased. Early trauma is a well-established Conclusions.– In patients with depression, monotherapy with ser-
risk factor for developing depressive disorders. However, our traline increased the level of non-BDNF neurotrophins, however,
knowledge of potential psychological factors mediating trauma- treatment with dosulepin and venlafaxine did not produce any
depression relationship is limited. In light of the current findings significant changes.
both risk and protective factors are involved in the development Disclosure of interest.– The authors have not supplied a conflict of
of any psychopathology. Psychological resilience may have a pro- interest statement.
tective function for depressive symptoms development. It was
consistently demonstrated that higher levels of resilience go in line
with lower severity of depression. E-PP0369
Our goal is to test a hypothesis that cognitive biases and psycholog- Adherence to antidepressant
ical resilience mediate the relationship between exposure to early
traumatic experiences and current depressive symptoms in young
therapies in patients with depressive
adults and to investigate the role of gender in this relationship. disorders attending an outpatient
Methods.– 2218 non-clinical young adults completed an online clinic in a Public Mental Health
survey consisting of selected items from several questionnaires Hospital, Antioquia - Colombia 2017
including: a short version of the Center for Epidemiological L. Martinez-Sanchez, J. Restrepo Zapata, G. Martínez Dominguez,
Studies-Depression Scale (CES-D), Traumatic Experience Check- M. Rodríguez Gázquez, J. Gaviria García, A. Urrego Vásquez, J.
list (TEC), Childhood Experience of Care and Abuse Questionnaire Ospina Sánchez, N. Morales Quintero* , F. Hernández Restrepo, S.
(CECA.Q), Davos Assessment of Cognitive Biases Scale (DACOBS- Ochoa Uribe
18), Connor-Davidson Resilience Scale (CD-RISC-10). Parallel Universidad Pontificia Bolivariana, School of Medicine, Medellín,
mediation analyses were performed. The role of gender was con- Colombia
sidered. * Corresponding author.
Results.– A significant standardized indirect effect of childhood
trauma on depressive symptoms through cognitive biases and Background and aims.– To determine the level of adherence to
resilience was found. A standardized direct effect of childhood antidepressant therapies and associated factors in patients with
traumatic life events on depressive symptoms remained also sig- depressive disorders.
nificant, meaning that mediation is complementary. An analysis by Methods.– A cross-sectional analytical study was conducted in
gender showed similar results for women and men. patients with diagnosis of depressive disorder. The sample was for
Conclusions.– Cognitive biases and resilience are important, but not convenience; a survey was designed including sociodemographic,
exclusive, mechanisms of the relationship between early trauma clinical and therapeutic variables; Morisky-Green instrument,
and depressive symptoms. Questionnaire of patients beliefs about their medication (BMQ)
Disclosure of interest.– The authors have not supplied a conflict of and Simplified questionnaire of adherence to medication (SMAQ)
interest statement. were also used, which are validated to be applied on depression.
The qualitative variables were evaluated with absolute and relative
frequencies; a bivariate analysis was performed.
E-PP0368 Results.– This study included 54 patients, the average age was
Effect of sertraline, dosulepin and 49.5 ± 13.7 years and 83.3% were women. All patients had the
venlafaxine on non-bdnf diagnosis of major depression, and 9.25% also had anxiety disor-
der. According to the Morisky test, only 37% of the patients were
neurotrophins in patients with compliant to the pharmacological treatment, although it was not
depression: a cohort study a statistically significant finding, the women were less compliant
B.R. Mishra1* , R. Maiti2 , S. Nath1 , A. Mishra2 , P. Sahoo1 , M. Jena2 than men (33.3% versus 55.6%; p = 0.21).
1 All India Institute of Medical Sciences, Bhubaneswar, Psychiatry, Conclusions.– The beliefs that patients have regarding medication
Bhubaneswar, India; 2 All India Institute of Medical Sciences, do not have a great impact on the adherence to antidepressant
Bhubaneswar, Pharmacology, Bhubaneswar, India therapy. However, it was evidenced that adherent patients had
less doubts about the medication administered compared to the
non-adherent.
Background and aims.– The neurotrophic hypothesis of depression
has been mostly studied with a focus on brain-derived neurotrophic
interest statement.
factor (BDNF) leading to lack of data on non-BDNF neurotrophins.
The aim of this study was to evaluate the effect of antidepres-
sant drugs on changes in serum Nerve growth factor (NGF),
Neurotrophin-3 (NT-3) and Neurotrophin-4 (NT-4).
E-PP0370 Background and aims.– Electroconvulsive therapy (ECT) is an effec-

Interleukin 6 levels in major tive treatment for late-life depression (LLD). However, there is a
depressive disorder and serotonin concern about the possible negative impact of ECT on cognition.
Our aims were to map the change of Mini-Mental State Exami-
transporter polymorphism correlates nation (MMSE) scores during and after ECT, and to compare the
A. Munjiza1* , M. Kostic2 , D. Pesic1 , M. Mitkovic-Voncina3 , I.
evolution of MMSE-scores in a group of cognitively impaired and
Markovic4 , V. Dobricic5 , I. Novakovic6 , D. Lecic-Tosevski7
1 Institute of Mental Health, Day Hospital for Adolescents, Belgrade,
unimpaired patients.
Methods.– Patients aged 55 years and older with unipolar depres-
Serbia; 2 Institute of Mental Health, Faculty of Medicine, University of
sions were included. MMSE was assessed one week prior to ECT,
Belgrade, Day Hospital for Adults, Department for Affective Disorders,
weekly during ECT, one-week and six months after the last ECT.
Belgrade, Serbia; 3 Institute of Mental Health, Faculty of Medicine,
Piecewise random Liniear Mixed Models were used to obtain trends
University of Belgrade, Day Hospital for Adolescents, Belgrade, Serbia;
4 Faculty of Medicine, University of Belgrade, Institute for
in cognition.
Results.– 110 patients were included. The MMSE-score increases
Biochemistry, Belgrade, Serbia; 5 Institute of Neurology, Genetics,
significantly during ECT. During the follow-up period MMSE-score
Belgrade, Serbia; 6 Institute of Neurology, Faculty of Medicine,
remains stable. The group with a low cognitive performance at
University of Belgrade, Genetics, Belgrade, Serbia; 7 Institute of
baseline increases significantly on the MSSE during the course of
Mental Health- Serbian Academy of Sciences and Arts, Department
ECT. The group with no cognitive impairment at baseline remains
for research and education, Belgrade, Serbia
the same during the ECT course. After the ECT course, the MMSE-
score still increases slightly but significantly in both groups.
Background and aims.– It has been proposed that interleukin 6 (IL- Conclusions.– ECT does not cause deleterious cognitive effects dur-
6) is involved in the pathophysiology of major depressive disorder ing and until six months after the index course in patients with
(MDD). One of posible pathways is through controlling SERT levels LLD, as measured with the MMSE. Even in the event of a baseline
and consequently serotonin reuptake. Aims: To compare IL-6 levels cognitive impairment, MMSE-scores improve significantly during
between patients with MDD and healthy controls; to analyze the ECT and six months after ending it. The presence of pretreatment
associations of IL-6 levels with socio-demographics, clinical char- cognitive impairment should not urge clinicians to withhold ECT
acteristics and with serotonin transporter polymorphism in patient in older patients with severe depression. Weighing pros and cons,
group. MMSE may still be useful in screening for cognitive impairment in
Methods.– Blood samples were obtained from 60 patients who ful- older patients.
filled DSM-IV-R criteria for a current major depressive episode Disclosure of interest.– The authors have not supplied a conflict of
without psychotic symptoms and 53 healthy controls, matched for interest statement.
age and gender. Participants were administered the Beck Depres-
sion Inventory (BDI), the Hamilton Depression Rating Scale (HDRS)
E-PP0372
and the Hamilton Anxiety Rating Scale (HARS). The 5- HTTLPR dele-
tion (L/S) polymorphism was assayed using gel electrophoresis of Monitoring ect-related anxiety: the
PCR products, and serum IL-6 concentration was determined by ect-related anxiety questionnaire
enzyme-linked immunosorbent assay. (ERAQ)
Results.– The concentration of IL-6 was significantly higher in J. Obbels1* , K. Vanbrabant2 , E. Verwijk3 , F. Bouckaert4 , P. Sienaert5
patients compared to healthy controls. Serum levels of IL-6 were 1 KU Leuven, University of Leuven, University Psychiatric Center KU
not associated to any clinical and socio-demographic character- Leuven, Academic Center for ECT and Neuromodulation, Kortenberg,
istics or the severity of symptoms. Majority of patients were Belgium; 2 KU Leuven, University of Leuven, University of Leuven,
heterozygotes for the serotonin transporter polymorphism (5- Leuven, Belgium; 3 Academic Medical Center Amsterdam, University
HTTLPR) with higher mean values of IL-6, comparing to two other of Amsterdam, Parnassia Psychiatric Center, Department of Medical
homozygous forms, but this difference was not statistically signif- Psychology, Neuropsychology Department, Department of
icant. Psychology, Brain and Cognition, ECT Department, Amsterdam, The
Conclusions.– Interleukin 6 could be an important marker for major Netherlands; 4 KU Leuven, University of Leuven, University
depressive disorder in adult patients. However, there is a need to Psychiatric Center KU Leuven, Academic Center for ECT and
search for more precise, person orientated reasons to explain the Neuromodulation, Kortenberg, Belgium; 5 University Psychiatric
role of it in the pathogenesis of depression. Center KU Leuven, Academic Center for ECT and Neuromodulation,
Disclosure of interest.– The authors have not supplied a conflict of Kortenberg, Belgium
interest statement. * Corresponding author.
Background and aims.– Although electroconvulsive therapy (ECT) is

E-PP0371 an effective and safe treatment, a significant proportion of patients
MMSE during ect in late-life is afraid of the treatment and therefore refuses it. A questionnaire
designed to measure ECT-related anxiety is currently not avail-
depression: useful or useless?
able. We report the development and psychometric evaluation of
J. Obbels1* , K. Vansteelandt2 , E. Verwijk3 , F. Bouckaert2 , P.
the ECT-related anxiety questionnaire (ERAQ), a questionnaire that
Sienaert2
1 KU Leuven, University of Leuven, University Psychiatric Center KU measures anxiety with respect to ECT in clinical practice.
Methods.– This study was conducted at two psychiatric hospitals in
Leuven, Academic Center for ECT and Neuromodulation, Kortenberg,
Belgium and The Netherlands. Patients who were about to start
Belgium; 2 KU Leuven, University of Leuven, University Psychiatric
with or were having an ECT course were included. ECT-related
center KU Leuven, Academic Center for ECT and Neuromodulation,
anxiety was measured with a Dutch self-designed questionnaire
Kortenberg, Belgium; 3 Academic Medical Center, Amsterdam,
(17 items, four-point scale). We used an exploratory (EFA), con-
Parnassia Psychiatric Institute, University of Amsterdam, Department
firmatory factor analysis (EFA) and Item Respons Theory (IRT) to
of Medical Psychology, Neuropsychology, Department of Psychology,
investigate psychometric properties of the ERAQ.
Brain and Cognition, ECT Department, Amsterdam, The Netherlands
* Corresponding author. Results.– 185 patients were included. The scale was unidimensional.
The location parameters for the 17 parameters reflected a sizeable
underlying anxiety for ECT (−1.06; 2.02).
Conclusions.– ERAQ is a valid questionnaire to measure ECT-related symptoms of depression, cognitive functioning, impulsivity, side
anxiety. ERAQ offers a global score in the form of the sum of 17 effects and social functioning.
items on a 4-category response scale as a measure of severity of Methods.– The participants of this study consist of patients who
ECT-related anxiety. Moreover, the ERAQ can differentiate between have been diagnosed with depression and prescribed an SSRI
various topics of anxiety and can inform the clinician about the (n = 30) or agomelatine (n = 30). On the first day of treatment,
specific aspects of an ECT-course that trigger less or more anxiety. a socio-demographic data form and SCID-I were applied to all
The differentiation of the ERAQ between various topics and inten- patients. Afterwards, the patients were called in for consultations
sities of anxiety can have an important role in the development of in the first and fourth week of treatment. In every consultation,
psychoeducational programs and in guiding clinicians to talk with the patients were evaluated with the Hamilton Depression Scale,
patients and relatives about their anxieties. the Clinical Global Impression Scale, the Social Functioning Scale,
Disclosure of interest.– The authors have not supplied a conflict of the Suicide Probability Scale, the UPSS-Impulsive Behaviour Scale,
interest statement. the Epworth Sleepiness Scale and the UKU-Side Effect Rating Scale
in addition to cognitive tests comprising of the Stroop Test, the
Trail-Making Test and the Verbal Fluency Test.
E-PP0373 Results.– Patients on SSRI showed better treatment response and
Are remitted affective disorders and remission rates at the end of the first month. SSRI’s caused more
high familial risk of affective autonomic and sexual side effects compared to agomelatine. No
difference was observed between the effects of the two medica-
disorders associated with metabolic
tions on cognitive-social functioning, impulsivity, sleeping patterns
syndrome and peripheral markers of and suicide probability. Improvement in cognitive functioning was
inflammation and oxidative stress? correlated with decrease in symptoms of depression. Moreover,
N.M. Ottesen cognitive performance in the first week of treatment does not pre-
Psychiatric Center Copenhagen, Copenhagen Affective Disorder dict the outcome of treatment.
Research Center, Copenhagen, Denmark Conclusions.– New drugs with mechanisms based on diverse neuro-
transmitter systems are needed in order to improve remission rates
and to reduce autonomic-sexual side effects at the same time.
Background and aims.– Metabolic Syndrome (MetS) is associated
with reduced life expectancy in patients with affective disorders,
interest statement.
however whether MetS also plays a role before the onset of affec-
tive disorder is unknown. We aimed to investigate whether MetS,
inflammatory markers or oxidative stress act as risk factors for E-PP0375
affective disorders and whether MetS is associated with increased
Incidence of acute cardiovascular
inflammation and oxidative stress.
Methods.– We conducted a high-risk study including 204 monozy- diseases in population with
gotic (MZ) twins with unipolar or bipolar disorder in remission or depression in Russia/Siberia: gender
partial remission (affected), their unaffected co-twins (high-risk) features. based on WHO
and twins with no personal or family history of affective disor- MONICA-psychosocial study
der (low-risk). Metabolic Syndrome was ascertained according to E. Gromova, V. Gafarov, D. Panov* , E. Krymov, I. Gagulin, A.
the International Diabetes Federation (IDF) criteria. Inflammatory Gafarova
markers and markers of oxidative stress were analyzed from fasting NIITPM - Branch of Institute of Cytology and Genetics, Collaborative
blood and urine samples, respectively. Laboratory of Cardiovascular Diseases Epidemiology, Novosibirsk,
Results.– The affected and the high-risk group had a significantly Russia
higher prevalence of MetS compared to the low-risk group (20% * Corresponding author.
vs. 15% vs. 2.5%, p = 0.0006) even after adjusting for sex, age, smok-
ing and alcohol consumption. No differences in inflammatory and Background and aims.– To determine gender differences in the
oxidative markers were seen between the three groups. Further, prevalence of depression in an open population of 25–64 y and
MetS was associated with inflammatory markers and oxidative to assess risk of CVD in the population of Russia/Siberia.
stress was to some extend correlated with inflammation. Methods.– Under the III screening of the WHO MONICA-
Conclusions.– Metabolic syndrome is associated with low-grade psychosocial program a random representative sample of the pop-
inflammation and may be a risk factor and a trait marker for affec- ulation aged 25–64 years of Novosibirsk (men = 657, women = 870)
tive disorders. This suggests the importance of early intervention was examined in 1994. Depression measured at the baseline.
and preventive approaches targeted towards unhealthy lifestyle Myocardial infarction (MI) and stroke were detected in women
factors that may contribute to later psychopathology. (15 and 35) and in men (30 and 22, respectively) over the 16-year
Disclosure of interest.– The authors have not supplied a conflict of period.
interest statement. Results.– 54.5% of women and 29% of men had depression, 11.8% of
women and 3.1% had a major depression (p = 0.0001). MI risk in peo-
ple with depression was higher in women (HR = 2.5) than in men
E-PP0374 (HR = 2). MI risk was 1.6-fold higher in men after adjustment. The
Effects of antidepressants with greatest risk of MI was in men (HR = 6.8) and women (HR = 6.3) at
different mechanisms of action on the age of 55–64 years, as well as in men with college or elementary
education level, in those with heavy manual work and in men who
cognitive functioning, side effects and
were never married, divorced or widowed. Stroke risk was higher
social functioning in men (HR = 5.8) than in women (HR = 4.6) with depression. The
C. Erdogan, H. Ozdemir* , O.M. Kocak, S.V. Buturak risk of stroke was higher in men with an initial level of education,
1 University of Kirikkale, Department of Psychiatry, Kirikkale, Turkey
in widowed men and divorced men (p for all < 0.05).
Conclusions.– Women are more likely to be depressed. MI risk was
Background and aims.– The aim of the study was to compare the higher in women than in men with depression; risk of stroke was
effects of two antidepressants of different mechanisms of action - higher in men than women. The risk of CVD in men with depression
selective serotonin reuptake inhibitors (SSRI) and agomelatine- on is aggravated by a social gradient.
Disclosure of interest.– The authors have not supplied a conflict of for aggressive IBD. Corticosteroid treatment may induce symptoms
interest statement. of mood disorders.
The aim of study was to examine the relationship between severity
of depressive symptoms and IBD activity.
E-PP0376 Methods.– Study was conducted on a sample of patients with
Association between cognitive IBD and no previous history of mental disorders. Beck Depression
symptoms and everyday functioning Inventory (BDI) was used to evaluate depression. Collected data
processed using methods of descriptive and analytical statistics.
in patients with major depressive
Results.– A total of 137 patients with IBD, of whom 103 with Crohn’s
disorder (MDD) in routine clinical disease and 34 with ulcerous colitis, were divided into two groups,
practice in Greece those in exacerbation (30.66%) and those in remission (69.34%).
A. Galanopoulos1 , D. Roukas2 , D. Karaiskos2 , I. Argyropoulos3 , A. Based on BDI scoring, subjects were classified into six groups, one
Spyropoulou2 , P. Vassilopoulou2 , P. Fotiadis3 , E. Papalexi1* considered normal (26.28%) and five with some level of depression.
1 Lundbeck Hellas, Medical Department, Athens, Greece; 2
Statistical analysis showed positive association between depres-
Psychiatrist, Medical Office, Athens, Greece; 3 Psychiatrist, Medical sion and IBD in group with exacerbation, with no statistically
Office, Thessaloniki, Greece significant difference between males and females in both groups.
Corticosteroids were used by 19 patients, all with exacerbation of
disease, so it was not possible to assess their exact influence on
Background and aims.– Clinical remission, as measured by com-
the development of depressive symptoms independent of the IBD
monly used rating scales, although considered as a successful
activity.
treatment outcome, does not necessarily indicate patients’ func-
Conclusions.– This study confirmed the positive correlation
tional recovery. Patients’ level of functioning is related, apart from
between depression and exacerbation of IBD, without difference
mood symptoms, to other clinical domains of major depressive
in relation to gender. The impact of IBD corticosteroid treatment
disorder (MDD), such as cognitive symptoms.
on the onset of depression requires additional research.
The aim of the current study analysis was to assess cognitive func-
tion in MDD patients clinically responded to treatment in clinical
interest statement.
practice in Greece, applying both clinician and patient ratings and
to investigate associations between cognitive symptoms and every-
day functioning. E-PP0378
Methods.– This was a non-interventional, cross-sectional multi-site
Further validation of the postpartum
study in outpatients with MDD clinically responded to antidepres-
sant treatment. Cognitive symptoms were evaluated by patient- depression screening scale-19
rated PDQ-D (Perceived Deficits Questionnaire-Depression) and by A.T. Pereira1* , S. Xavier1 , J. Azevedo1 , M.J. Soares1 , C. Marques1 , S.
clinician-based 6th item of MADRS scale (concentration difficul- Meneses1,2 , M. Marques1,2,3 , A. Macedo1,2
1 Faculty of Medicine, University of Coimbra, Institute of
ties). Patient functioning was assessed by Sheehan Disability Scale
(SDS) total score. Stepwise multiple linear regression and correla- Psychological Medicine, Coimbra, Portugal; 2 Coimbra Hospital and
tion analysis were applied. University Centre, Psychiatry department, Coimbra, Portugal; 3
Results.– 335 patients with MDD participated in the study. 62.4% Miguel Torga Higher Institute, Miguel Torga Higher Institute,
had concentration difficulties (6th MADRS Item score ≥2). “Concen- Coimbra, Portugal
tration difficulties” was the most severely rated MADRS item and
the only item correlated with functioning (p < 0.001). PDQ-D total
Background and aims.– We have recently obtained a 19-item version
score was also significantly correlated with functioning (p < 0.001).
of the Postpartum Depression Screening Scale (PDSS-19; Marques
The highest rated PDQ-D item was the decision-making item. 46%
et al., 2017) through Confirmatory Factor Analysis of the PDSS-21
of patients reported “having trouble making decisions” at least 3–5
(Pereira et al., 2013), a Portuguese short-form of the original PDSS
times during the last 7 days.
(35 items), less time consuming, but equally valid. Actually, PDSS-
Conclusions.– Patients included in the analysis (MADRS responders)
19 presented better reliability and construct validity than PDSS-21
had very frequently cognitive symptoms, either clinician or patient
assessing postpartum depressive symptoms. However, it is neces-
reported. Furthermore, cognitive function has been strongly linked
sary to analyze its operational characteristics before using it for
with everyday functioning in clinical practice in Greece.
screening purposes.
Objectives: To determine PDSS-19 cut-off points and associated con-
interest statement.
ditional probabilities to screen for major depression, according to
DSM-5.
Methods.– 388 women (Mean age = 32.75 ± 4.721 years;
E-PP0377
range = 22–44) in the first sixth months of the postpartum
Depression in inflammatory bowel period (M = 12.09 ± 4.251 weeks; range = 5–20) completed the
disease: relation to disease activity PDSS-21 and were interviewed with the Diagnostic Interview for
B. Pavkovic1* , M. Zaric1 , M. Markovic1 , M. Klacar2 , M. Kuljanin3 , A. Psychological Distress–Postpartum (Xavier et al., 2015). This is a
Caricic3 , A. Huljic3 , B. Prokic3 semi-structured clinical interview developed by our team, to assess
1 Health Center “Dr. Simo Milosevic” Cukarica, Psychiatry, Belgrade,
the most prevalent psychiatric disorders in the perinatal period
Serbia; 2 Health Center “Dr. Simo Milosevic” Cukarica, Pediatrics, according to the DSM-5 diagnostic criteria. MedCalc was used to
Belgrade, Serbia; 3 Health Center “Dr. Simo Milosevic” Cukarica, perform ROC analysis; cut-off points and associated conditional
General Medicine, Belgrade, Serbia probabilities adjusted to the real prevalence were determined.
Results.– Major depression prevalence was of 7.7% (n = 30). The
cut-off point maximizing the Youden Index (J = .73, 95% CI [.55-
Background and aims.– Inflammatory bowel disease (IBD) affects
.80]) was 32 (95% CI: [29–34]), resulting in sensitivity of 93.33%
individuals not only physically but also mentally. The evidence
(77.9%–99.2%), specificity of 78.77% (74.2%–88.9%), positive predic-
indicates that depression is more common in patients with IBD
tive value of 29.5% (24.3%–35.4%) and negative predictive value of
and symptoms of depression are more severe during the periods
98.7% (96.7%–99.5%).
of active IBD. Baseline depression is associated with a higher risk
Conclusions.– The PDSS-19 presents a good combination of sensi- France; 4 Sorbonne University, Sorbonne University, Paris, France; 5
tivity and specificity, being useful for postpartum depression both INSERM- Institut de Psychiatrie GDR 3557, Laboratoire de
in research and in primary health care settings. “Physiopathologie des maladies Psychiatriques”, Paris, France; 6 Paris
Disclosure of interest.– The authors have not supplied a conflict of Descartes University, Sorbonne Paris Cité, Paris, France; 7 Institut
interest statement. Pasteur, Imagopole-CITech, Paris, France; 8 INSERM, u1141, Paris,
France; 9 Paris Diderot University, Sorbonne Paris Cité- UMRS 1141,
Paris, France; 10 Centre Hospitalier de Versailles, Service Universitaire
E-PP0379 de Psychiatrie d’adultes, Le Chesnay, France; 11 La Pitié-Salpêtrière
Prevalence and incidence of perinatal Hospital, Assistance Publique-Hôpitaux de Paris, Multidisciplinary
depression in Portugal: ten years later Intensive Care Unit, Department of Anesthesiology and Critical Care,
A.T. Pereira1* , S. Xavier1 , J. Azevedo1 , M.J. Soares1 , C. Marques1 , S. Paris, France; 12 Centre Hospitalier Sainte-Anne, Department of
Meneses1,2 , M. Marques1,2,3 , B. Maia4 , A. Macedo1,2 Intensive Care, Paris, France; 13 Hôpital Lariboisière, Assistance
1 Faculty of Medicine, University of Coimbra, Institute of Publique Hôpitaux de Paris, Service de Biochimie et Biologie
Psychological Medicine, Coimbra, Portugal; 2 Coimbra Hospital and Moléculaire, INSERM U942, Paris, France; 14 Centre Hospitalier
University Centre, Psychiatry Department, Coimbra, Portugal; 3 Sainte-Anne, Laboratoire Hospitalo-Universitaire de
Miguel Torga Higher Institute, Miguel Torga Higher Institute, Neuropathologie, Paris, France
Coimbra, Portugal; 4 The Catholic University of Portugal, Faculty of
Philosophy and Social Sciences, Braga, Portugal
* Corresponding author. Background and aims.– In recent decades, comprehensive evidence
has accumulated that inflammation might be implied in the eti-
Background and aims.– A decade ago we reported that the post- ology of major depressive disorder besides monoamine imbalance
partum prevalence of Major Depression at the third month classically described. In inflammatory conditions, the degradation
postpartum was of 11.7%. Using the Postpartum Depression of tryptophan is prioritized towards the production of kynure-
Screening Scale (PDSS-21/24) cut-offs, we estimated that the preg- nine, leading to the production by microglial cells of quinolinic
nancy and postpartum prevalence of Major Depression/DSM-IV, acid (QUIN), an excitotoxic NMDA receptor agonist. Ketamine is
Depression/ICD-10 and of Mild/Moderate Depression with Somatic a very promising antidepressant and its NMDA antagonism might
Syndrome or Severe without Psychotic Symptoms/ICD-10 was counteract QUIN accumulation.
around 20% (10% for this last category). In this study, the immune-modulating capacities of ketamine was
Objectives: To estimate the postpartum Major Depression preva- investigated in depressed patients by examining the effect of
lence according to the DSM-5 diagnostic criteria and the caseness ketamine treatment on tryptophan metabolites plasma levels.
proportions (point-prevalence and incidence) of perinatal depres- Methods.– 15 treatment-resistant depressed in-patients received a
sive disorder, according to the PDSS-21/24 cut-offs, based on data cure of ketamine infusions (0.5 mg/kg intravenously), one or two
from a population-based sample collected more recently, ten years times per week. Before and after each infusion, depression severity
later. was assessed with the MADRS and plasma levels of tryptophan,
Methods.– 388 women (Mean age = 32.75 ± 4.721 years) answered kynurenine, kynurenic acid (KYNA), and QUIN were measured by
the PDSS-24 in the second pregnancy trimester and the PDSS-21 at HPLC and mass spectrometry.
the third month postpartum. The Diagnostic Interview for Psycho- Results.– We observed that pre-treatment KYNA/QUIN is a predictor
logical Distress was used only in the postpartum. of MADRS score after a ketamine infusion and after a whole cure of
Results.– The postpartum prevalence of Major Depression/DSM-5 ketamine independently to depression severity (beta = 0.28 ± 0.07,
was of 7.7%, with the majority presenting the specifier “with anx- p = 0.0002; beta = 1.05 ± 0.35, p = 0.016 respectively). The variation
ious distress”. According to the PDSS cut-offs, the point-prevalence of QUIN after a ketamine infusion is also a predictor of the per-
of the three diagnostic categories was respectively of 19.1%, 24.0%, centage of variation in MADRS score after a ketamine infusion
and 16.1% in pregnancy and of 19.3%, 17.5% and 9.5% in the postpar- (beta = 0.35 ± 0.14, p = 0.015).
tum. Considering the PDSS scores prospectively, from pregnancy to Conclusions.– Ketamine acts not only by counteracting QUIN on
postpartum, 9.5%, 9.3% and 5.2% were new cases of clinical depres- NMDA receptors but by reducing its production. As the trypto-
sion. phan metabolism pathway is mainly supported by microglia in the
Conclusions.– In comparison with our results from a decade ago, brain, these findings underpin the immune-modulatory capacity
the postpartum depression prevalence is lower; the percentages of of ketamine, suggesting microglia as a key therapeutic target and
women with clinical significant depressive symptoms are similar. QUIN as a biomarker of ketamine response.
This is in line with the best available literature, including the find- Disclosure of interest.– The authors have not supplied a conflict of
ings that depressive symptoms prevalence is higher in pregnancy. interest statement.
interest statement.
E-PP0381
Effect of agomelatine 25–50 MG on
E-PP0380 social functioning in adults and older
Kynurenine pathway as a target and patients with major depressive
biomarker of the antidepressant disorder over 6 months
effect of ketamine S. Kennedy1 , R. Heun2 , V. Olivier3 , F. Picarel4* , C. De Bodinat3
1
A.C. Petit1,2* , F. Verdonk2,3,4 , P. Abdel-Ahad1,5,6 , F. Vinckier1,5,6 , G. University of Toronto, St. Michael’s Hospital, Centre for Depression
Jouvion2 , P. de Maricourt1,5,6 , G. Ferreira de Medeiros2 , A. & Suicide Research, Toronto, Canada; 2 Derby City General Hospital,
Danckaert2,7 , J. Van Steenwinckel8,9 , M. Blatzer2 , A. Maignan10 , O. Radbourne Unit, Derby, United Kingdom; 3 Institut de Recherches
Langeron11 , T. Sharshar12 , M.O. Krebs1,5,6 , J. Callebert13 , J.M. Internationales Servier, Neuropsychiatry, Suresnes, France; 4
Launay13 , F. Chrétien2,6,14 , R. Gaillard1,2,6 SERVIER, Global Medical Affairs, Suresnes, France
1 Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, * Corresponding author.
Paris, France; 2 Institut Pasteur, Experimental Neuropathology Unit,

Paris, France; 3 Saint Antoine Hospital, Assistance Publique-Hôpitaux Background and aims.– By assessing the level of functioning in addi-
de Paris, Department of Anaesthesiology and Intensive Care, Paris, tion to depressive symptoms, one likely achieves a more complete
picture of “real-world” outcomes of depressed patients.
The present work assesses the long-term effect of agomelatine on E-PP0383

functioning compared to placebo in adults and older patients suf- Vitamin d deficiency and depression: a
fering from Major Depressive Disorder (MDD).
preliminary study
Methods.– Data from two randomized, parallel, double-blind,
R.S. Romosan1* , L. Dehelean1 , A. Pantea2 , I. Drut2 , R. Balint2 , A.M.
placebo-controlled agomelatine studies, one in adult (average age:
Romosan1
44 years) and one in older MDD patients (average age: 72 years), 1 “Victor Babes” University of Medicine and Pharmacy, Neurosciences,
that evaluated the effect on social functioning are reported.
Timisoara, Romania; 2 “Victor Babes” University of Medicine and
The HAM-D17 scale was used to assess depressive symptoms. The
Pharmacy, Neurosciences, PhD Candidate, Timisoara, Romania
effect on functioning was assessed using the Sheehan Disability * Corresponding author.
Scale (SDS). SDS total and sub-item scores as well as the functional
remission (SDS total score ≤6) were evaluated. Background and aims.– Vitamin D deficiency, especially in devel-
Results.– In each study depressive symptoms and SDS scores sig- oped countries, has become an increasing problem in the past
nificantly improved versus placebo. In adults, the percentage of decades, both in regards to incidence and severity. Although there
remitters (HAM-D 17 total score ≤7) was 57.4% on agomelatine seems to be a direct link between depression and severe Vitamin
versus 22.0% on placebo and the percentage of patients achiev- D deficiency, it is yet unclear whether the depression might be
ing functional remission was 53.1% on agomelatine versus 27.8% secondary to the Vitamin D deficiency or if the deficiency merely
on placebo. In olders, the percentage of remitters was 33.8% on increases the severity of depressive symptoms.
agomelatine versus 22.9% on placebo and the percentage of patients The purpose of our study was to assess antidepressant therapy
achieving functional remission was 37.4% on agomelatine versus efficacy in two patient samples (with and without Vitamin D sup-
21.7% on placebo. plementation).
Conclusions.– In long term agomelatine improves the social func- Methods.– The study was conducted on 63 patients diagnosed with
tioning of adults and older depressed patients. recurrent depressive disorder, with either a moderate or severe
Disclosure of interest.– The authors have not supplied a conflict of episode (according to ICD-10 diagnostic criteria), admitted in our
interest statement. psychiatric clinic during January and August 2018. All patients
included in our study had a severe Vitamin D deficiency. Of these, 33
patients received antidepressant (SSRI) treatment coupled with an
oral supplement of 1000 U.I./day Vitamin D. The other 30 patients
E-Poster Presentation: Depression - Part V received antidepressant (SSRI) medication without the supplement
of Vitamin D. Symptom severity was assessed by using the MADRS
scale.
E-PP0382 Results.– There were no significant differences between symptom
Some features of clinical severity between the two study samples upon study entry. After 15
pathomorphosis of depressive days of hospitalization, we found significantly lower MADRS scores
in the patient sample with Vitamin D supplementation (p = 0.02).
disorders
Conclusions.– Vitamin D supplementation may speed up recov-
N. Pshuk* , O. Belov
1 National Pirogov Memorial Medical University, Vinnytsya, Medical ery in depressed patients with severe Vitamin D deficiency, thus
increasing the quality of life for patients with recurrent depressive
disorder.
Postgraduate Education, Vinnytsya, Ukraine
interest statement.
Background and aims.– Depressive disorders are one of the main
problems in modern psychiatry. Study of their pathomorphosis is
an important factor for depressive disorders prevention. E-PP0384
Aim of this study was to reveal features of clinical pathomorphosis Can whole body cryotherapy become
of bipolar disorder (BD) and major depressive disorder (MDD) over an add-on treatment for depressed
the last 30 years. people?
Methods.– Medical documentation of patients with BD and MDD, J. Rymaszewska1 , K. Lion1 , T. Pawłowski1 , J. Ubysz2 , J.
who were treated during 1988–2018, was analyzed. A total of 112 Rymaszewska2* , D. Szcześniak1 , B. Stańczykiewicz3
cases of BD and 67 cases of MDD were studied. 1 Wrocław Medical University, Psychiatry, Wrocław, Poland; 2
Results.– The study revealed that percentage of nonspecific symp- Wroclaw Medical University, Student Scientific Association at
toms during the initial stage of BD and MDD increased, in particular, Department of Psychiatry, Wrocław, Poland; 3 Wrocław Medical
emotional hyperesthesia from 18.2% to 39.0% in BD, and from 23.8% University, Nervous System Diseases, Wrocław, Poland
to 25.0% in MDD, asthenia–from 21.2% to 41.5% in BD, and from * Corresponding author.
19.0% to 29.2% in MDD, somatic and vegetative symptoms–from
15.2% to 24.4% in BD, and from 14.3% to 16.7% in MDD, sleep disor- Background and aims.– Whole-body cryotherapy (WBC) is already
ders - from 24.2% to 36.6% in BD and from 28.6% to 33.3% in MDD. proven method in somatic medicine and among standards of
In the manifest stage structure, percentage of anxiety symptoms supportive therapies in rheumatoid, neurological diseases (e.g.
increased from 39.4% to 63.4% in BD, and from 42.9% to 66.7% in multiple sclerosis) and biological rejuvenation (athletes). WBC is
MDD, somatic and vegetative symptoms–from 57.6% to 80.5% in a short, repeatable application of stimuli of very low tempera-
BD, and from 61.9% to 87.5% in MDD, sleep disorders from 78.8% to ture (<−110 ◦ C) in a short period of time (2–3 min) on whole body
100% in BD, and from 81.0% to 100% in MDD. surface to provoke positive physiological and immunological reac-
Conclusions.– Thus, clinical pathomorphosis of depressive disor- tions of human body. There is limited data (Rymaszewska 2003;
ders is characterized by tendency towards increase in severity of Rymaszewska 2008; Miller 2011) about the WBC in mood disor-
nonspecific symptoms at the initial and manifest stages, as well as ders, although the effectiveness of WBC may be associated with
increase of anxious forms of depression in general. inflammatory depression theory.
Disclosure of interest.– The authors have not supplied a conflict of The aim was to confirm if short, repetitive exposition to extreme
interest statement. low temperatures may support treatment of depressed patients.
Methods.– According to RCT protocol 117 patients with depres- E-PP0386

sive disorder (F.32, F.33) under standard psychopharmacology Depression and depressive symptoms
were assessed for eligibility, among which 92 were randomized
in patients with breast cancer
into experimental (n = 50) and control (n = 42) group. Experimen-
E. Samirkhanov
tal group undergo 10 sessions of WBC daily from −110 to −160 ◦ C,
Tashkent Medical Academy, Psychiatry and Narcology, Tashkent,
2–3 min each, whereas control into −50 ◦ C. Before the first and after Uzbekistan
the last WBC the Beck Depression Inventory and self-report scale of * Corresponding author.
“well-being” including: mood, level of motivation and sleep quality
with Visual Analogue Scale were collected. Background and aims.– Identify the features of anxiety-depressive
Results.– Finally, 33 participants in experimental and 30 in con- disorders that occur in women diagnosed with breast cancer after
trol group ended the study. The level of depressive symptoms surgical treatment.
significantly decreased after WBC (p < 0.05). More significant Methods.– The research material served data on 39 patients aged
improvement of self-reported well-being comparing to controls 35 to 69 years with the first currently established diagnosis of
was also observed (VAS, p < 0.05). breast cancer stage I–IV. Group control, comparable to the main age
Conclusions.– The results are very promising and prove that WBC as group (p > 0.05), was 30 clinically healthy women. An assessment
an adjuvant treatment in depression is worth exploring in further of the severity of anxiety symptoms and depression symptoms
studies. was performed by the Hamilton (HARS) and Depression Rating
Disclosure of interest.– The authors have not supplied a conflict of Scale (HDRS). Freiburg Personal Inventory (FPI). The structure of
interest statement. the internal picture of the disease - TOBOL (LOBI). Assessment of
quality of life indicators - SF-36, in adaptation of the Interethnic
Center for the Study of Quality of Life (Uzbekistan).
E-PP0385 Results.– 81% of patients undergoing mastectomy have moderate
A randomized, double-blind study to severe symptoms of depression, 93% have moderate to severe
comparing the efficacy and safety of symptoms of anxiety. In patients with mastectomy of breast can-
trazodone oad and venlafaxine XR for cer, signs of 11 of 13 possible types of attitudes towards the disease
were found. The most frequently identified inadequate types of
the treatment of patients with major relationships with the disease were depressive (18.7%), anxious
depressive disorder (14.7%) and sensitive (13.5%). Paranoid (0.3%), harmonious (2.1%)
E. Salvatori1* , A. Comandini1 , G. Di Loreto1 , L. Olivieri1 , S. and anosonomic (3.7%) types of attitudes towards the disease were
Tongiani1 , U. Albert2 , A. Fagiolini3 , S. Kasper4 most rarely identified.
1 Angelini S.p.A., RR&D Research, Regulatory & Development, S.
Conclusions.– All patients with breast cancer undergoing mas-
Palomba, Pomezia RM, Italy; 2 University of Bologna, Department of tectomy have anxiety-depressive disorders with psychogenic,
Biomedical and Neuromotor Sciences, Bologna, Italy; 3 Santa Maria somatogenic, and mixed according to the states of genesis. Between
alle Scotte University Hospital, Department of Molecular Medicine, these conditions there are differences in the severity of the struc-
Siena, Italy; 4 Medical University Vienna, Department of Psychiatry tural components of the complex depressive syndrome, which
and Psychotherapy, Vienna, Austria predetermines the differences in the response to the use of various
treatment methods.
Background and aims.– To generate new data about the efficacy and
interest statement.
safety of trazodone OAD in patients with Major Depressive Dis-
order (MDD), a randomized, non-inferiority clinical trial against
venlafaxine XR, was implemented. E-PP0387
The primary efficacy end-point of the study was the demonstration
of the non-inferiority of trazodone OAD vs. venlafaxine XR evalu- Face memory and the perception of
ated as change from baseline at final visit (day 56) on the 17-items emotions in women with depression
HAMD total score. V. Savickaya
Methods.– Randomized, venlafaxine-controlled, double-blind, par- Republican Scientific and Practical Center for Mental Health,
allel design study. A total of 166 patients in the trazodone OAD Organizational-Methodical Department, Minsk, Belarus
300 mg/day group and 158 in the venlafaxine XR 75 mg/day group
were randomized.
Background and aims.– Intensive study of the processes of the per-
Results.– Both treatments showed a good efficacy in terms of
ception of emotions in the recent decades has shown correlation
reduction of HAMD-17 total score at day 56 (ITT: trazodone OAD
between such perception and the effectiveness of social function-
−12.9 ± 6.82, venlafaxine XR −14.7 ± 6.56; PP: trazodone OAD
ing and the quality of life. At the same time, the peculiarities of the
−15.4 ± 5.32, venlafaxine XR −16.4 ± 5.39), demonstrating the non-
emotion perception in correlation with the severity of depressive
inferiority of trazodone OAD vs. venlafaxine XR.
symptoms have not been studied enough.
Notably, patients in the trazodone OAD arm achieved a statisti-
Objectives.– To study the face memory and the emotion perception
cally significant reduction in the HAMD-17 score after 7 days of
in women suffering from depression.
treatment only.
Methods.– The evaluation of the emotion perception produced by
The most frequent AEs were dizziness and somnolence in the tra-
the neuropsychological battery (PennCNP) of the University of
zodone OAD group, nausea and headache in the venlafaxine XR
Pennsylvania. The assessment of the severity of depression was
group. Overall, the intensity of AEs experienced on both treatments
carried out using the Beck questionnaire.
was mild to moderate in majority of the cases.
Results.– As a result, the decrease of the ability to remember faces
Conclusions.– This trial confirmed that trazodone OAD and ven-
and the decrease of the ability to distinguish the differences in the
lafaxine XR represent an effective and relatively safe therapeutic
expression of emotions have been revealed in women, suffering
option for patients with MDD; moreover, trazodone OAD was able
from the depressive disorder. The degree of the deficits in such
to reduce MDD symptoms after only 7 days of treatment, providing
women is on the level between the results of patients suffering
a fast onset of action.
from schizophrenia and mentally healthy women. The negative
moderate correlations were revealed between the severity of the
interest statement.
depression and the parameters “the amount of correct answers in
detecting the happiness” (r = −0,399) and “the amount of correct University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa,
answers in detecting sadness” (r = −0,294) in the group of women, Italy, Department of Neuroscience, Rehabilitation, Ophthalmology,
suffering from depression. Genetics, Maternal and Child Health DINOGMI, Genoa, Italy; 2
Conclusions.– In the conducted study it was revealed, that the face Kutvolgyi Clinical Center, Semmelweis University, Department of
memory and the ability to detect differences in emotions in women Psychiatry and Psychotherapy, Budapest, Hungary, Hungary; 3
with the depressive disorder is less expressed than in schizophrenia University of Campania ‘Luigi Vanvitelli’, Naples, Department of
patients. This fact corresponds to a dimensional model of psychotic Psychiatry, Naples, Italy; 4 Suicide Prevention Center, Sant’Andrea
disorders. Hospital, University of Rome, Rome, Italy, Department of
Disclosure of interest.– The authors have not supplied a conflict of Neurosciences, Rome, Italy; 5 University of Toronto, Toronto, ON,
interest statement. Canada, Department of Psychiatry, Toronto, Canada; 6 Section of
Psychiatry, University of Genoa, IRCCS Ospedale Policlinico San
Martino, Genoa, Italy, Department of Neuroscience, Rehabilitation,
E-PP0388 Ophthalmology, Genetics, Maternal and Child Health DINOGMI,
Clinical characteristics of chronic Genoa, Italy
depression - data from a large
naturalistic follow-up Background and aims.– Specific predictors of relapse/recurrence in
F. Seemüller1,2* , M. Kolter2 , R. Schennach2,3 , R. Musil2 , M.
major depressive disorder (MDD) have been identified. However,
Riedel2,4 , P. Falkai2 , M. Hans-Jürgen2 , F. Padberg2
1 Kbo-Lech-Mangfall-Klinik Garmisch-Partenkirchen, Psychitry, evidence to this regard are currently inconsistent across studies.
Thus, the present study aimed to identify the most relevant socio-
Psychotherapy and Psychosomatic, Garmisch, Partenkirchen,
demographic and clinical predictors of MDD recurrence in a large
Germany; 2 Ludwig-Maximilians-University Munich, Psychiatry and
sample of 508 MDD outpatients.
Psychotherapy, Munich, Germany; 3 Schön Klinik Roseneck Haus
Methods.– The sample of this naturalistic cohort study included 508
Prien, Pschotherapy and Psychosomatics, Prien, Germany; 4
currently euthymic MDD patients (mean age = 54.1 ± 16.2) of which
Sächsisches Krankenhaus Rodewisch, Psychiatry, Psychotherapy and
53.9% had a single and 46.1% had recurrent depressive episodes.
Psychosomatics, Rodewisch, Germany
* Corresponding author. A detailed data collection was performed and the illness histo-
ries were retraced through clinical files and lifetime computerized
Background and aims.– Around 20% - 30% of depressed individu- medical records.
als experience a chronic form of depression lasting two or more Results.– Compared to MDD patients with single episode, MDD
years. Chronic depression is associated with higher rates of physical patients with recurrent episodes significantly differ regarding age,
comorbidity, functional impairment and poses a significant burden age at first treatment, gender, working status, and family history of
over long stretches of time on relatives as well as on society as a mental disorders, typical depressive characteristics at first episode,
whole. psychotic symptoms at first episode, duration of untreated illness,
The aim of this study was to shed light on clinical characteristics of melancholic characteristics, seasonality, and comorbid cardio-
chronic depression. vascular/endocrinological conditions. However, after multivariate
Methods.– Naturalistic multisite follow-up on inpatients with analyses adjusting for age, gender, educational level, and working
major depressive disorder. Patients with chronic depression were status, recurrence was associated with typical depressive fea-
compared with patients with nonchronic depression on clini- tures at first episode (ˇ = 4.635; p ≤ 0.001), melancholic features
cal symptomatology, sociodemographic information, clinical and (ˇ = 4.011, p ≤ .05), age at first treatment (ˇ = −9.723; p ≤ .005),
personal history, personality factors and psychiatric comorbidity, duration of untreated illness (ˇ = −5.630; p ≤ .05), and current age
outcome as well as treatment specifics (ˇ = 14.702; p ≤ 0.001).
Results.– Data of 954 patients were included in the analysis. 113 Conclusions.– The predictors of recurrence of major depressive
patients (11,8%) fulfilled criteria of chronic depression. Chronic episodes identified in the current study may aid in the stratification
depression was significantly associated with a low age at onset, of patients who could benefit from more intensive maintenance
a relatively higher age at first treatment, fewer years of profes- treatments for MDD. However, clinicians should rapidly identify
sional training, use of benzodiazepines as well as psychotherapy cases that are not likely to recur in order to avoid unnecessary
during the current episode, a depressive personality disorder and a treatments which are commonly considered as the standard of care.
low degree of extraversion (NEO-FFI). Baseline HAMD and MADRS Disclosure of interest.– The authors have not supplied a conflict of
ratings were comparable. However, chronic depressed patients interest statement.
showed a longer hospital stay and showed lower remission rates,
increased rates of suicidal ideation as well as higher depression
ratings and lower extraversion scores at discharge. E-PP0390
Conclusions.– These findings support the notion that both ill- Differential clinical and
nesses belong to the same disorder category–unipolar affective neurocognitive characteristics
disorder–and that the distinguishing dimensions of symptom
between patients with major
severity and chronicity are valid specifiers for classifying unipolar
affective disorders. depressive disorder and
Disclosure of interest.– The authors have not supplied a conflict of treatment-resistant depression
interest statement. G. Serafini1* , G. Giacomini1 , C. Porcelli1 , S. Zanaboni1 , M. Pompili2 ,
M. Amore1
1 Department of Neuroscience, Rehabilitation, Ophthalmology,
E-PP0389 Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry,
Socio-demographic and clinical University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa,
predictors of recurrence in major Italy, Department of Neuroscience, Rehabilitation, Ophthalmology,
Genetics, Maternal and Child Health DINOGMI, Genoa, Italy; 2 Section
depressive disorder
of Psychiatry, Sapienza University of Rome, Sant’Andrea Hospital,
G. Serafini1* , X. Gonda2 , A. Fiorillo3 , M. Pompili4 , A.F. Carvalho5 ,
Department of Neurosciences, Rome, Italy
M. Amore6 * Corresponding author.
1 Department of Neuroscience, Rehabilitation, Ophthalmology,
Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry,

Background and aims.– Nearly 30% of subjects with major hormone levels and increased risk of incident depressive symp-
depressive disorder (MDD) do not appropriately respond to cur- toms.
rently available antidepressant medications (NTRD). Patients with Conclusions.– There was no apparent association between subclin-
treatment-resistant depression (TRD) commonly experience an ical hypothyroidism and incident depressive symptoms in a large
important disability and psychosocial impairment. Our aim was prospective cohort of middle-aged men and women.
to compare clinical and neurocognitive features of TRD and NTRD Disclosure of interest.– The authors have not supplied a conflict of
individuals as well as identify possible predictors of resistance. interest statement.
Methods.– Overall, 40 outpatients with TRD (based on Thase and
Rush staging method) and 23 with NTRD were recruited at the
section of Psychiatry, University of Genoa (Italy). Participants com- E-PP0392
pleted the Continuous Performance Test (CPT), Stroop Color Word Factors influencing help-seeking
Interference (SCWT), Trail Making Test (TMT-A/B), Verbal Fluency behavior in Korean depressed
test (VFT), and Rey Auditory Verbal Learning Test (RAVLT).
adolescents
Results.– TRD patients reported a significantly lower education
M.S. Shin1* , R.M. Do2 , J. Park3 , S. Lee3 , J. Kim3 , M. Cho3
(p ≤ 0.05) and socio-economic (p ≤ 0.001) levels, poorer insight 1 Seoul National University College of Medicine, Psychiatry, Seoul,
(p = 0.01), higher stressful lifetime events (p ≤ 0.05), greater ill-
Republic of Korea; 2 Seoul National University College of Medicine,
ness duration (p = 0.001) and illness episodes (p = 0.01), later age
Cininical Medical Science, Seoul, Republic of Korea; 3 Seoul National
at first hospitalization (p ≤ 0.05), higher antipsychotic treatments
University Children’s Hispotal, Child and Adolescent Psychiatry,
(p ≤ 0.001), and a more impaired performance at CPT, TMT-B,
Seoul, Republic of Korea
VFT, RAVLT, and SCWT relative to NTRD subjects. After multi- * Corresponding author.
variate regression analysis, the amount of variation in TRD that
was accounted for all potential predictors was 57.5% (R2 = 0.575) Background and aims.– Depressed adolescents are less likely to
with the SCWT CW (p < 0.005), SCWT WI (p < 0.05), poorer socio- seek any professional help. A computer-based cognitive behavior
economic (p ≤ 0.05) level, and higher stressful lifetime events therapy can be an alternative treatment for helping them. The pur-
(p ≤ 0.05) that resulted significant predictors of resistance. pose of this study was to explore promoting and inhibiting factors
Conclusions.– TRD and NTRD subjects significantly differed with for help-seeking behaviors among Korean depressed adolescents.
resistance which was associated with specific clinical and neu- We also examined the variables influencing attitude toward the
rocognitive predictors. Differential clinical characteristics and computer-based psychotherapy.
selective neurocognitive impairments should be identified by clin- Methods.– A total of 246 adolescents (mean age: 15.10 years) from
icians as early targets for treatment. 3 middle schools and 3 high schools in South Korea participated in
Disclosure of interest.– The authors have not supplied a conflict of this study. They completed questionnaires individually to measure
interest statement. depression, help-seeking experiences (trust in therapist, stigma tol-
erance, recognition of need for help, interpersonal openness), and
attitude toward computer-based psychotherapy. Data were ana-
lyzed using SPSS.
E-Poster Presentation: Depression - Part VII Results.– Depressed adolescents showed lower scores of stigma
tolerance (F = 6.47, P < 0.05) and interpersonal openness (F = 31.51,
P < 0.001) than normal adolescents. Female students with prior
E-PP0391 help-seeking experiences had lower interpersonal openness score
Subclinical hypothyroidism and (F = 12.443, P = 0.001) than males, while males with prior experi-
incident depression in young and ence showed high score of trust in therapist (F = 4.859, P < 0.05)
than females. Male students had more positive perception about
middle age adults
computerized psychotherapy than females (F = 6.778, P < 0.01).
S. Shim1* , H. Jung2 , S.W. Hahn3 , J. Yang4 , J.S. Kim1 , Y.S. Lee1 , I.H.
Conclusions.– To promote help-seeking behavior of depressed ado-
Lee2 , M.G. Hwang3
1 Soon Chun Hyang University Hospital, Psychiatry, Cheonan, lescents, it could be helpful to improve help-seeking attitude such
as trust in therapist with carefully considering gender difference. A
Republic of Korea; 2 Soon Chun Hyang University Hospital,
computerized CBT can be an alternative therapeutic option espe-
Psychiatry, Bucheon, Republic of Korea; 3 Soon Chun Hyang
cially for male depressed adolescents.
University Hospital, Psychiatry, Seoul, Republic of Korea; 4 Chonbuk
National University Hospital, Psychiatry, Chonju, Republic of Korea
Background and aims.– The role of subclinical hypothyroidism in the

development of depression remains controversial. We examined E-PP0393
the prospective association between subclinical hypothyroidism Depressive symptomatology in full
and incident depressive symptoms. term pregnant women: prevalence
Methods.– We conducted a prospective cohort study in 220,545 and psychosocial factors
middle age adults without depression who underwent at least V. Silva1* , B. Rodrigues Maia2 , R. Miguelote1
2 comprehensive health exams between January 1, 2011 and 1 University of Minho, School of Health Sciences, Life and Health
December 31, 2014. Thyroid-stimulating hormone (TSH), free tri- Sciences Research Institute, Braga, Portugal, Braga, Portugal; 2 The
iodothyronine (FT3) and free thyroxin (FT4) levels were measured Catholic University of Portugal, Braga Regional Centre, Faculty of
by an electrochemiluminescent immunoassay. The study outcome Philosophy and Social Sciences, Braga, Portugal
was incident depressive symptom defined as a CES-D score >16. * Corresponding author.
Results.– During a median follow-up of 2 years, incident depressive
symptoms occurred in 7,323 participants. The multivariable- Background and aims.–
adjusted hazard ratio (HR) for incident depressive symptoms Introduction.– The prevalence of perinatal depression is quite high
comparing subclinical hypothyroid to euthyroid participants was and the deleterious consequences for the mother, baby and family
0.97 (0.87 to 1.09). Similarly, among euthyroid participants are well documented. Despite being an important public mental
(n = 87,822), there was no apparent association between thyroid
health, the studies exploring depression in full term pregnancy are Conclusions.– PPEP4ALL may be a cost-effective self-management
scarce. intervention for chronic depression.
Aim.– To calculate the prevalence of depression in full term preg- Disclosure of interest.– The authors have not supplied a conflict of
nancy and to explore some aetiological factors. interest statement.
Methods.– 403 women in full term pregnancy (37–41 weeks of ges-
tation) with a mean age of 30,5 years old (SD = 4,67; range = 18–41)
fulfilled a socio-demographic, psychosocial and obstetric question- E-PP0395
naire and the short version of the Postpartum Depression Screening Clinical study of panic attacks in
Scale (PDSS-24; Pereira et al., 2013). anxiety and depression
Results.– Prevalence of depression was found to be 38,7% (n = 156) S. Srivastava
based upon PDSS-24 cut-off scores (ICD-10–mild/moderate depres- None, None, Lucknow, India
sion with somatic syndrome or severe depression without * Corresponding author.
psychotic symptoms). Women with a planned pregnancy, mar-
ried, and with perceived social support were less likely to present Background and aims.– Although PA are known long back ago with
depression, 2 (1, n = 401) = 9,531, p = ,002; 2 (1, n = 401) = 5,996, different names, but recently it gained much attention not only by
p = ,014; and 2 (1, n = 402) = 10,678, p = ,001, respectively. Women psychiatrist but also by other specialities like Cardiologists, Physi-
with an history of significant life events were more likely to cians as its symptoms are much similar as cardiovascular disease.
present depression, 2 (1, n = 403) = 5,702, p = ,017). The full The aim of my study is to create awareness for cardiovascular symp-
model containing all predictors was statistically significant, 2 (4, toms of PA in anxiety and depression.
n = 398) = 20,048, p < ,001. Only two of the independent variables Methods.– Total 1192 patients (among them 584 of depression and
made a unique significant statistical contribution to the model 608 of anxiety disorder) were selected for study. All of them were
(perceived social support and marital status). Finally, the stronger thoroughly screened for PA during their course of illness and a
predictor of depression was perceived social support, recording an detailed treatment history were also obtained.
odds ratio of 2,62. Results.– Approximately 85% patients of anxiety disorder consulted
Conclusions.– Our results confirm the need to screen for depression doctor for their PA while only46% patients of depression con-
in full term pregnancy and improve our knowledge about depres- sulted doctor for PA. Among anxiety disorder majority approx
sion aetiology in this particular pregnancy stage. 90% consulted cardiologist firs then casualty, medical o.p.d., family
Disclosure of interest.– The authors have not supplied a conflict of physician respectively in decreasing order. On other hand majority
interest statement. 74% patients of depression did not sought any treatment for PA.A
very interesting finding which I found, although anxiety disorder
patients seeks very early consultation to doctor but reaches to psy-
E-PP0394 chiatrist very late in comparison to depression who consults doctor
Economic evaluation of a very late, but reaches to psychiatrist early.
self-management intervention Conclusions.– In my study I found that most of the anxiety disorder
patients when reached to me were also fulfilling the criteria of PD
(PPEP4ALL) for patients with
which further complicates the treatment, On other hand patients
persistent depressive disorder and of depression reached to me very late for treatment.
their partners: a multi-center Disclosure of interest.– The authors have not supplied a conflict of
pragmatic randomized controlled trial interest statement.
E. Solis* , I. Carlier, A.M. van Hemert
LUMC, Psychiatry, Leiden, The Netherlands
Positive correlation of a
Background and aims.– According to the Dutch guidelines for
patient-reported measure of fatigue
depression, treatment for patients with Persistent Depressive Dis-
order (PDS; >2 years depressed) should focus on rehabilitation. with depressive symptoms in a phase
The availability of rehabilitation-focused treatments in Dutch 2 major depressive disorder trial of
mental healthcare, however, are limited. We propose a short SAGE-217
self-management intervention, namely the “Patient and Partner E. Suthoff1* , H. Gunduz-Bruce2 , C. Silber2 , R. Lasser2 , A. Arnaud1 ,
Education Program for All Chronic Diseases” (PPEP4All), in which A. Sankoh3 , H. Li3 , I. Nandy3 , V. Bonthapally1 , B. Werneberg2 , J.
the patient and the partner (i.e., life partner or other close relation) Jonas2 , J. Doherty2 , S. Kanes2
learn to deal more effectively with the chronic illness. The aim of 1 Sage Therapeutics Inc., Health Economics and Outcomes Research,
this study is to evaluate psychiatric rehabilitation in patients with Cambridge, USA; 2 Sage Therapeutics Inc., Medical Science,
PDS and their partners and to provide a cost-effective rehabilitation Cambridge, USA; 3 Sage Therapeutics Inc., Data Sciences, Cambridge,
protocol for chronic depression. USA
Methods.– Between April 2017 and October 2019, we aim to include * Corresponding author.
144 patients from mental healthcare clinics in The Netherlands.

Patients will be randomized to either PPEP4All (n = 72) or the stan- Background and aims.– Fatigue is a common comorbidity of major
dard treatment (n = 72). Participants must be at least 18 years, depressive disorder (MDD) and is associated with relapse. A pivotal
fluent in Dutch, have a main diagnosis of chronic depression, and trial examining the antidepressant efficacy of the investigational
a treatment indication for rehabilitation. Participants with severe GABAA receptor positive allosteric modulator SAGE-217 included
psychiatric or somatic comorbidity (such as psychosis, bipolar I an exploratory endpoint examining fatigue. This study examines
disorder, schizophrenia, or dementia), a high suicide risk, and an the correlation of depressive symptoms with patient-reported
IQ < 80 will be excluded. At baseline, 3-, 6-, and 12 months, partic- fatigue.
ipants will complete questionnaires. Methods.– Subjects (n = 89) with MDD and a Hamilton Rating Scale
Results.– PPEP4All, compared with standard treatment, is expected for Depression (HAM-D) total score ≥22 were randomized 1:1 to
to lead to lower costs in the Dutch healthcare system and a better receive SAGE-217 Capsule 30 mg or placebo for 14 days, with four
quality of life, more mental resilience, fewer symptoms, and less weeks follow-up. Depressive symptoms were evaluated by HAM-D
disease burden for both the patient and partner. and the Montgomery and Åsberg Depression Rating scale (MADRS).
Patient-reported fatigue was also measured using the Fatigue Asso- The work was supported by National Science Centre, Poland, grant
ciated with Depression (FAsD) scale. Adverse events (AEs) were no.2016/21/B/NZ5/00148.
reported through Day 42. Disclosure of interest.– The authors have not supplied a conflict of
Results.– At the Day 15 primary endpoint, a significantly greater interest statement.
least-squares mean HAM-D total score reduction was observed
for SAGE-217 (−17.4) versus placebo (−10.3; p < 0.001). Addition-
ally, SAGE-217 showed significant improvements versus placebo E-PP0398
in FAsD total (−1.6 vs. −1.0, p = 0.017) and fatigue impact (−1.7 vs. Lurasidone for the treatment of major
−1.0, p = 0.004) scores. In the total study population, at Days 15 and depressive disorder with mixed
42, changes in HAM-D and MADRS total scores were moderately-to-
features: results of a 12-week
highly correlated with changes in FAsD total, fatigue impact, and
fatigue experience scores (p < 0.001; all relationships). The most open-label extension study
common AEs (≥5%) in the SAGE-217 group were headache, nausea, S.M. Stahl1 , A. Pikalov2 , M. Tocco2* , Y. Mao3 , A. Loebel2
1 University of California at San Diego School of Medicine, and the
dizziness, and somnolence.
Conclusions.– Over the study period, total population patient- Neuroscience Education Institute, Psychiatry, La Jolla, USA; 2
reported fatigue was moderately-to-highly correlated with depres- Sunovion Pharmaceuticals Inc., Medical Affairs, Marlborough, USA; 3
sive symptoms. SAGE-217 administration significantly reduced Sunovion Pharmaceuticals Inc., Statistics, Marlborough, USA
depressive symptoms and patient-reported fatigue versus placebo
at Day 15. Background and aims.– To evaluate the efficacy and tolerability
Disclosure of interest.– The authors have not supplied a conflict of of longer-term treatment with lurasidone in patients with major
interest statement. depressive disorder (MDD) with mixed features.
Methods.– Patients in the US (N = 48) with MDD who presented with
2 or 3 manic symptoms and who completed 6 weeks of double-
E-PP0397
blind, placebo-controlled treatment with lurasidone 18.5–56 mg/d
Brain transcriptome analysis in the rat were enrolled in a 12-week, open-label (OL) extension study in
model of depression which patients were continued on lurasidone (Lur-Lur group) or
D. Szczepankiewicz1 , P. Celichowski2 , P. Zakowicz3 , E. switched from placebo to lurasidone (Pbo-Lur group). The primary
Banach-Kasper4 , K. Kuras5 , P. Kołodziejski1 , E. efficacy measure was the Montgomery-Åsberg Depression Rating
Pruszynska-Oszmalek1 , M. Sassek1 , L. Nogowski1 , J. Pawlak3 , J. Scale (MADRS).
Twarowska-Hauser3 , A. Szczepankiewicz5* Results.– A total of 48 patients entered the extension study, with
1 Poznan University of Life Sciences, Animal Physiology and
a mean MADRS at OL-baseline: Lur-Lur (N = 29), 15.0; Pbo-Lur
Biochemistry, Poznan, Poland; 2 Poznan University of Medical (N = 19), 24.1; 9 patients (18.8%) discontinued prematurely. Mean
Sciences, Department of Histology and Embryology, Poznan, Poland; 3 change from OL-baseline to week 12 (OC/LOCF) in MADRS total
Poznan University of Medical Sciences, Department of Psychiatric scores for the Lur-Lur group was −4.1/−3.3, and for the Pbo-Lur
Genetics, Poznan, Poland; 4 Nencki Institute, Department of group was −11.2/−9.7. In the OL study, adverse events (≥5%)
Molecular and Cellular Neurobiology, Warsaw, Poland; 5 Poznan were akathisia (10.4%), diarrhea (8.3%), upper respiratory infec-
University of Medical Sciences, Laboratory of Molecular and Cell tion (8.3%), and headache, sedation, nausea, fatigue (6.3% each).
Biology, Poznan, Poland For the Lur-Lur and Pbo-Lur groups, respectively, median change
in metabolic parameters (DB-baseline to week 12-OC) were as fol-
lows: cholesterol (−6.5 and +1.5 mg/dL), triglycerides (−3.5 and
Background and aims.– In the study we used animal model of +20.0 mg/dL), and HbA1c (+0.15% and +0.30%). There were no clin-
depression to analyze the differences in the expression of rat ically significant changes in body weight. Treatment-emergent
brain transcriptome in relation to the control animals. The most mania or hypomania as an adverse event occurred in 2 patients
involved in the pathogenesis of depression and the best doc- (4.2%).
umented changes concern two brain regions–hippocampus and Conclusions.– Treatment with lurasidone (18.5–56 mg/d) was gen-
amygdala. Therefore, changes in gene expression profile were per- erally safe and well-tolerated for up to 12 weeks in patients with
formed in these two brain regions. MDD with mixed features. Continued improvement in depressive
Methods.– In the study we used male Wistar rats. The depression symptoms was observed.
was induced using chronic mild stress protocol (CMS). Depressive Disclosure of interest.– The authors have not supplied a conflict of
behavior was assessed using behavioral tests (forced swim test, interest statement.
open field test, elevated maze test) and change of >40% in compar-
ison to the baseline results was regarded as depression. Total RNA
isolation was performed using NucleoSpin Total RNA/Protein Isola- E-PP0399
tion Kit. Gene expression analysis was performed on the Affymetrix
Distinguishing subgroups based on
platform using WT Rats Microarray GeneChip Rat Gene 2.0ST Array.
Gene expression patterns were compared between control group psychomotor functioning among
and individuals with induced depression. patients with major depressive
Results.– There were significant differences in the expression of disorder
185 genes in amygdala (>2-fold change, p < 0.05). These genes L. Van Diermen1* , D. Schrijvers1 , O. Cools1 , T. Birkenhäger2 , E.
were clustered into 26 significantly enriched biological processes, Fransen1 , B. Sabbe1
with the most prominent associated with locomotory behaviour 1 UAntwerpen, Faculty of Medicine and Health Sciences, Antwerp,
(decreased gene expression) and transmembrane transport, includ- Belgium; 2 Erasmus University Medical Center, Psychiatry,
ing ions and metal ions and neurogenesis (increased gene Rotterdam, The Netherlands
expression). We did not find significant differences in hippocam- * Corresponding author.
pal transcriptome between animals with depressive behaviour and

control animals. Background and aims.– Retardation and agitation are symptoms
Conclusions.– The genes showing different expression in depression ofmajor depressive disorder (MDD), and their presence couldplay
may be a starting point for translational studies to identify targets a role in determining clinically meaningful depressivesubtypes
for new therapies of depression. such as nonmelancholic depression (NMD) andmelancholic depres-
sion (MD). In this project, we exploredwhether three depression Disclosure of interest.– The authors have not supplied a conflict of
subgroups (NMD, MD with psychoticsymptoms, and MD without interest statement.
psychotic symptoms) could be distinguished based on objective
measures of psychomotorfunctioning.
Methods.– Sixty-nine patients withMDD underwent extensive E-PP0401
clinical and psychomotor testingprior to treatment with elec- Basal and stimulated inflammation
troconvulsive therapy. Psychomotorfunctioning was assessed markers and the course of individual
subjectively using the CoreAssessment of Psychomotor Change
symptoms in depressed patients
(CORE) and objectivelyby means of both 24-h actigraphy and per-
W. Van Eeden1* , A. van Hemert1 , I. Carlier1 , B. Penninx2 , F.
formance on a finemotor drawing task.
Lamers2 , F. Eiko3 , R. Schoevers4 , E. Giltay3
Results.– The daytime activity levelsmeasured by actigraphy were 1 Leiden University Medical Center, Psychiatry, Delft, The
significantly lower (F = 7.1, p = 0.0004) in MD patients both with and
Netherlands; 2 VUMC, Psychiatry, Amsterdam, The Netherlands; 3
without psychoticsymptoms than in those with NMD. No objective
Leiden university, Social Science, Leiden, The Netherlands; 4
psychomotorvariable was able to distinguish between melancholic
University Medical Center Groningen, Psychiatry, Groningen, The
patientswith and those without psychotic symptoms.
Netherlands
Conclusions.– The depression subtypes NMD, MD with psychotic- * Corresponding author.
symptoms, and MD without psychotic symptoms are notmarked by
increasing psychomotor retardation, possibly becausepsychomo- Background and aims.– Multiple studies found an association
tor disturbance in MD with psychotic symptomsoften consists of between inflammatory markers and major depressive disorder
agitation rather than retardation, or amixture of the two. However, (MDD). It has been theorized that some people with chronic low-
psychomotor functioning asmeasured by actigraphy can be used to grade inflammation are at increased risk of MDD, as an exacerbated
distinguish betweenNMD patients and MD patients. form of sickness behaviour. We hypothesized that inflammation
Disclosure of interest.– The authors have not supplied a conflict of is only related to a subset of MDD symptoms that overlap with
interest statement. sickness behaviour.
Methods.– We tested the association between basal and
lipopolysaccharide (LPS)-induced inflammatory markers with
E-PP0400 individual MDD symptoms over a period of nine years using
Neuroticism and chronicity as multivariate mixed model adjusted for relevant covariates in 2931
predictors of 9-year course of participants of the Netherlands Study of Depression and Anxiety
individual depressive symptoms (NESDA-cohort).
W. Van Eeden1* , A. van Hemert1 , I. Carlier1 , B. Penninx2 , P. Results.– At baseline, participants were 42.2 years old, 66.5% were
Spinhoven3 , E. Giltay1 women, and 53.6% had a current mood or anxiety disorder. In
1 Leiden University Medical Center, Psychiatry, Leiden, The line with our hypothesis, it turned out that specific inflammatory
Netherlands; 2 Vumc, Psychiatry, Amsterdam, The Netherlands; 3 markers were associated with a higher severity low energy, psy-
University Leiden, Psychology, Leiden, The Netherlands chomotor problems, arousal and anhedonia, but not to all other
* Corresponding author. MDD-symptoms over 9 years follow-up.
Conclusions.– Inflammation is not related to depression as a uni-
Background and aims.– Major Depressive Disorder (MDD) is a fied syndrome, but rather to the presence and course of certain
heterogeneous psychiatric illness, with large between-person MDD symptoms that are related to sickness behaviour. Low-grade
differences in symptomatology and highly variable course trajecto- inflammation may be a novel target for treatment strategies in a
ries. We hypothesized that chronicity (i.e., being depressed for 24 subgroup of patients with MDD.
months during the preceding 48 months at baseline) and neuroti- Disclosure of interest.– The authors have not supplied a conflict of
cism at baseline would predict adverse course trajectories during 9 interest statement.
years of follow-up in different magnitudes for individual depressive
symptoms.
Methods.– In total, 560 patients with MDD were included from the E-PP0402
Netherlands Study of Depression and Anxiety (NESDA-cohort). A The use of subcutaneous ketamine for
multivariate linear mixed model with repeated measures was used treatment-resistant depression
with IDS-SR item score as outcome variable using both history of A. Vargas Alves Nunes1* , E. Carrara2 , S. Odebrecht Vargas Nunes3 ,
chronicity and neuroticism separately as main independent vari- I. Fernandes Jorge2 , E. Alves2 , M. Haddad2
ables. For each individual symptom models were adjusted for age, 1 Instituto de Assistencia Médica ao Servidor Publico Estadual de São
gender, and baseline depression severity (sum-score). Paulo, Psychiatry, Sao Paulo, Brazil; 2 Instututo de Assistência Médica
Results.– Patients were on average 42.7 (SD: 12.1) years old, and ao Servidor Público Estadual de São Paulo, Psychiatry, Sao Paulo,
64.7% were women. Patients with chronic depression or with Brazil; 3 Universidade Estadual de Londrina, psychiatry, Londrina,
high levels of neuroticism showed largely similar absolute rates Brazil
of decline over time as compared to their counterparts. How- * Corresponding author.
ever, as symptoms had higher starting points for mood, cognitive,
and somatic/vegetative symptoms, respectively, symptom severity Background and aims.–
remained higher over time. Especially the symptoms low self- Introduction.– Major depressive disorder is highly common with
esteem and high interpersonal sensitivity remained persistently up to 50% to 60% of the patients not achieving adequate response
higher. following antidepressant treatment. In this scenario, ketamine
Conclusions.– Chronicity and neuroticism at baseline predict a emerges as an important alternative to conventional treatments,
higher severity of mood and cognitive symptoms over 9 years with its action of being an antagonist of N-methyl-d-aspartate
time. This is also the case although to a smaller extent regard- (NMDA) receptor, once its has a quick and effective action.
ing, severity of somatic/vegetative symptoms. Low self-esteem and Ketamine is most frequently administered intravenous. However,
high interpersonal sensitivity and may be important for personal- oral, sublingual, transmucosal, intranasal, subcutaneous (SC), and
ized treatment of patients with chronic depression or high levels intramuscular routes of administration have also been examined.
of neuroticism. Aim.– This study aims to investigate whether SC ketamine is effec-
tive in the treatment of unipolar major depression and if it has more
effective and sustainable response than electroconvulsivetherapy Background and aims.– Prior studies have suggested that exercise
(ECT). might help patients with depression. However, a systematic review
Methods.– Participants will be comprised of patients with unipolar including the most recent RCTs is lacking. We wanted to determine
depression resistant to conventional treatment, men and women, if exercise has a positive effect on depression and to examine for
aged ≥18 across a range of ethnicities, recruited from General Hos- which severity of depression the best results are obtained.
pital Servidor of State of São Paulo, Brazil. Participants will be Methods.– A systematic review following the PRISMA criteria was
separeted in two groups. The first one will recieve a SC administra- conducted on 20th December 2017, including literature searches
tion of ketamine in the dose of 0,5 mg/kg weekly, for 6 weeks. The in Embase, Medline and PsycInfo. RCTs published in English in
second will be submitted to ECT treatment, two sessions a week, for 2007–2017, involving adults with unipolar depression rated with
at least 8 sessions. The response of each treatment will be evaluated either BDI, HDRS or MADRS and treated with exercise as either main
and compared by MADRS questionnaire. or adjunct intervention were included. From an initial retrieval of
Results.– We expect that SC ketamine has a good response in the 293 articles, 12 articles describing RCTs were included and rated
treatment of major depression and that it has a similar response according to GRADE criteria.
compared to ECT. Results.– In general, exercise significantly reduced depression
Conclusions.– Conclusion: Once SC ketamine is a secure, quick and scores when used as an adjunct treatment of depression. Factors
simple procedure, it is a promising alternative to available treat- that were seen as central to good outcomes were group workouts,
ments in psychiatry. good supervision and high motivation. Because the RCTs had not
Disclosure of interest.– The authors have not supplied a conflict of consistently classified the severity of depression when they mea-
interest statement. sured the effect of exercise, we could not determine which severity
of depression that had the best outcome of exercise.
Conclusions.– Exercise can be recommended as adjunct treatment
E-PP0403 of depression. Further primary studies should classify depression
Psychiatric evaluation for detection of severity to establish which of these groups has the best effect of
major depression in patients with exercise.
multiple sclerosis
interest statement.
D. Vasile* , O. Vasiliu
University Emergency Central Military Hospital “Dr. Carol Davila”,
Psychiatry Department, Bucharest, Romania E-PP0405
COMT VAL158MET polymorphism
Background and aims.– Major depression is frequently reported in influences the cerebral blood flow
patients with multiple sclerosis, and data from literature support changes related to psychomotor
values of 50% cases of dual diagnosis. Depression may nevertheless
retardation in major depressive
be difficult to diagnose because of several symptoms reported by
patients with multiple sclerosis which can overlap: fatigue, mem- disorder
ory and attentional deficits, low performance in daily activities. The Y. Yin
objective was to perform a literature search in order to find the Psychosomatics and Psychiatry, ZhongDa Hospital, School of
most appropriate instruments for detection of major depression in Medicine, Southeast University, Nanjing, China
patients diagnosed with multiple sclerosis.
Methods.– A search of major electronic databases (Cochrane,
Background and aims.– Previous studies revealed different CBF
PubMed, PsychInfo, EMBASE, CINAHL) was performed, using
changes of Major depressive disorder (MDD) patients with psy-
keywords “major depressive disorder”, “multiple sclerosis”, “psy-
chomotor retardation (PMR). While numerous studies consistently
chometric instruments”, and “diagnosis”.
reported decreased CBF of prefrontal cortex was associated with
Results.– A number of 267 papers published between 1998 and
PMR, several studies which found negative correlation between
2018 were found after the application of the search paradigm, and
PMR and the CBF of basal ganglia or precuneus were not well
33 remained after filtering out papers through inclusion/exclusion
repeated. The different CBF changes might result from other fac-
criteria. Several multiple sclerosis specific scales were identified
tors such as gene. This study aimed at investigating the influence of
in trials (N = 28) which included patients with major depression-
COMT Val158Met Polymorphism on the cerebral blood flow (CBF)
multiple sclerosis dual diagnosis, and the most cited were Multiple
changes in major depressive disorder (MDD) patients with psy-
Sclerosis Quality of Life −54 items, Functional Assessment of Multi-
chomotor retardation (PMR).
ple Sclerosis Questionnaire, Multiple Sclerosis Quality of Life Index,
Methods.– COMT Val158Met genotypes and arterial spin labeling-
and MS Impact Scale. Non-disease specific scales were identified in
magnetic resonance imaging (ASL-MRI) data of 98 Chinese Han
a large number of trials (N = 19), with Short Form Health Survey
subjects (59 MDD, 39 NC) were collected in this study. MDD patients
(SF-36) and EQ-5D being the most frequently applied.
were divided into PMR group (N = 22) and NPMR group (N = 37)
Conclusions.– Both disease-specific scales for the determination
according to the Salpetriere Retardation Rating Scale score. CBF
of quality of life in multiple sclerosis, and general scales may be
throughout the whole brain were analyzed based on the ASL-MRI
applied in patients who are also diagnosed with major depression.
data. The interactions between genotype and PMR on the CBF were
analyzed in a voxel-wise manner throughout the whole brain.
interest statement.
Results.– The interaction of PMR and Val158Met Polymorphism
primarily influenced the CBF of left precuneus and right caudate.
The Met allele led a deceased CBF in NC and NPMR group, but an
E-PP0404
increased CBF in PMR group.
Effect of exercise on depression: a Conclusions.– Our findings indicate COMT Met allele could modu-
systematic review late the CBF changes of left precuneus and right caudate in MDD
L.Y. Andorsen, R. Wynn* patients with PMR, which might interpret why previous studies
UiT - The Arctic University of Norway, Department of Clinical without considering the COMT genotype reported different results
Medicine, Tromsø, Norway in CBF changes of MDD patients with psychomotor retardation.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The mean number of anxious depression definitions met
interest statement. was 4.7 (SD = 2.1). Only 4.2% (n = 14) of the 331 patients did not
meet any anxious depression definition, and 28.1% (n = 93) met
all 7 definitions. The level of agreement between the definitions
E-PP0406 was significant, albeit modest (median kappa = .28). Discussion: The
Depression and anxiety after severe modest association between the different definitions of anxious
traumatic brain injury depression suggests that the results based on one approach towards
O. Zaitsev subtyping may not generalize to the DSM-5 anxious distress speci-
Burdenko National Medical Research Center, Psychiatry Research fier. It therefore cannot be assumed that the DSM-5 anxious distress
Group, Moscow, Russia specifier is valid just because other definitions of anxious depres-
* Corresponding author. sion have been shown to be valid.
Conclusions.– The modest association between the different defi-
Background and aims.– Was to study depressive and anxiety disor- nitions of anxious depression suggests that the results based on
ders in the process of mental recovery after severe traumatic brain one approach towards subtyping may not generalize to the DSM-5
injury (TBI). anxious distress specifier.
Methods.– Psychopathological investigation of mental recovery was Disclosure of interest.– The authors have not supplied a conflict of
performed in 153 survivors of severe TBI, with the initial coma interest statement.
score < 8 by GCS.
Results.– Depression was found in 48% of cases, anxiety in 38%.
Depression manifested significally earlier than anxiety. In 10% of
patients first signs of sadness were found at the level of disin- E-Poster Presentation: Depression Part I
tegrated consciousness as emotional reflection of fact of trauma
and handicap. After orientation recovery depression was found in
38% of patients and anxiety was in 10% only. On the way to pre- E-PP0408
morbid level rate of depression decreased down to 10% and rate Influence of parental dimensions in
of anxiety increased up to 38%. Depressive manifestation itself
relation to the development of
correlated with good recovery, especially in the longterm follow-
up (p < 0,001). Anxiety didn’t correlate with outcome. In cases of depressive symptoms among
marked and prolonged (>1 week) depression it was necessary to adolescents
use antidepressants, they were successfull only in 44% of them, in R. Addo1* , C. Åslund1 , S. Olofsdotter2 , K. Nilsson1
1 Uppsala University, Neuroscience, Vasteras, Sweden; 2 Uppsala
52% cases unfavorable side-effects were revealed. Exclusion of tri-
cyclic antidepressants, use of four-cyclic and serotoninergic ones University, Center for Clinical Research, Vasteras, Sweden
allowed to increase efficacy of antidepressive therapy to 59% and
reduce rate of side-effects to 29%. Anxiolytic treatment was suc-
Background and aims.– Previous research have shown that parental
cessful in 41% of courses, unfavorable side-effects was found in 35%.
dimensions are associated to the development of depressive symp-
Exclusion of benzodiazepine drugs increased efficacy up to 63% and
toms among children, less is known about the influence different
decreased side-effects down to 16%.
parental dimensions might have among adolescents. This study
Conclusions.– There is a further need to study depression and
describes the development of depressive symptoms among 13- and
anxiety disorders and search of their effective treatment for reha-
15 year old Swedish adolescents (N = 1541) during three years, in
bilitation of patients with severe TBI.
relation to the potential influence of parental dimensions
Methods.– Adolescents born in 1997 and 1999 were invited to par-
interest statement.
ticipate by completing a questionnaire sent by regular mail (wave
1). Three years later a second questionnaire was sent to the partic-
E-PP0407 ipants (wave 2).
Results.– Between wave 1, and wave 2, a 50% increase in estimations
What is anxious depression? Overlap of depressive symptoms were seen, although females reported a
and agreement between different higher level of depressive symptoms at both waves. All parental
definitions dimensions were related to depressive symptoms at wave 2. The
M. Zimmerman1* , S. Kerr2 , C. Balling2 , R. Kieffer2 , K. Dalrymple2 three positive dimensions were associated with a decreased level
1 Brown University, Psychiatry and Human Behavior, Providence, of depressive symptoms, and the three negative dimensions with
USA; 2 Rhode Island Hospital, Psychiatry, Providence, USA an increased level of depressive symptoms. Significant interaction
effects were found between depressive symptoms at wave 1 and
higher levels of the dimensions of structure and warmth, which
Background and aims.– A problem with the research on the signif- decreased the level of depressive symptoms at wave 2, as well as
icance of anxiety in depressed patients is that anxiety has been between sex and the dimensions of structure and coercion, where
characterized in different ways. Little research has examined the the influence of the parental dimensions were more pronounced in
concordance and overlap between the various definitions of anx- females.
ious depression. With research on the DSM-5 anxious distress Conclusions.– Parental influence on child mental health is often sug-
specifier just beginning, it will be important to understand how gested to decrease during adolescence. The present results suggest
defining anxious depression according to DSM-5 agrees with pre- that parental dimensions might be an important influence on the
viously studied definitions. In the present report from the Rhode development of depressive symptoms even in later adolescence.
Island Methods to Improve Diagnostic Assessment and Services Disclosure of interest.– The authors have not supplied a conflict of
(MIDAS) project we examined the association between the DSM-5 interest statement.
anxious distress specifier and 6 other approaches towards defining
anxious depression.
Methods.– Three hundred thirty-one patients with a principal
diagnosis of major depressive disorder were evaluated with semi-
structured diagnostic interviews.
E-PP0409 Results.– The prevalence of depressive symptoms was 64% while

Psychological problem in cancer 47% endorsed the presence of anxiety. 35% of respondents with
patients in rural India (West depressive symptoms fulfil the criteria for moderately to severe
depression. Approximately 27% of respondents with anxiety symp-
Bengal)–experience of an NGO toms found to have moderate to severe anxiety. Only 5% of patients
M. Aditya
with depression and 3% of patients with anxiety were receiving
Narikeldaha Prayas, Palliative Care, Purba Medinipur, India
psychiatric treatment.
Conclusions.– This study collaborates with studies from other pop-
Background and aims.– As in any developing countries state of West ulations to support that the rate of psychiatric disorder is high
Bengal in India has a huge psychological burden of cancer patients among people with rheumatic diseases and it appears to exceed
in any stage coming from rural area where awareness regarding the the rate found in the general population. Pending further scrutiny,
usefulness of cancer care in rather poor. Objective of this study is mechanisms are needed in Oman to increase the awareness among
to identify the main psychology difficulties in achieving the above physicians dealing with rheumatology patients. Such an undertak-
goal in a rural village setting in India. ing could include providing means for early detection and prompt
Methods.– Newly diagnosed or survivors cancer patients in need interventions.
of psychology support in various villages in of rural India were Disclosure of interest.– The authors have not supplied a conflict of
selected for this study. Their symptoms and managements in that interest statement.
rural surroundings were evaluated by an NGO (guidance of oncolo-
gist or psychologist) working in that area. An attempt was made to
E-PP0411
identify the main obstacles in getting proper psychological support
as well as cancer care in a rural setting. New initiatives of depression
Results.– Apart from pain, fatigue psycho-social problem also main management physician order at the
symptoms affecting these patients. In most patients pain and other mental hospital of ministry of health
symptoms were managed by different therapy but fear or men- in Saudi Arabia
tal trauma were grossly inadequate due to lack of properly trained N. Alsolami1* , Y.A. Alomi1-2
counsellor or psychiatric manpower in the rural India. However 1 Al Amal Medical Complex, Pharmacy Department, Riyadh, Saudi
regular homecare visits by a group of social workers were of Arabia; 2 Ministry of Health, Pharmacy Department, Riyadh, Saudi
immense help in these cancer patients. NGO team was well guided Arabia
by oncologist and psychiatric specialist. * Corresponding author.
Conclusions.– There is a wide gap of trained manpower in this filled
in rural areas of India. Dedicated groups from rural area itself need Background and aims.– The general administration of pharmaceuti-
encouragement and proper training, so that difficult symptoms can cal care stated evidence-based pharmacy guidelines at Ministry of
be managed locally along with necessary social and psychological Health hospitals and primary healthcare centers in 2015. The hos-
support to these patients. pital started with a standard disease like depression. The tax force
Disclosure of interest.– The authors have not supplied a conflict of team designed the updated guidelines and approved by an official
interest statement. body in the hospital.
Methods.– The form friendly used and very important in preventing
drug related problems and education system for healthcare staff.
E-PP0410 The depression physician order form consisted of patient demo-
The prevalence and risk factors of graphic data, the type or stage of disease, the first line of treatment,
depression and anxiety in patients the dose and duration of therapy, and the second line of choice if
existed. The co morbid disease with primary disease and appro-
with rheumatic diseases attending a
priate choice for each combined disease. The prescribed data and
tertiary care hospital in Muscat, Oman clinical pharmacist data as explored in the physician order form.
O. Al Salmi1* , R. Martin2 , S. Al-Adawi2 , B. Hassan3 , S. Murthi4 , Z. Al Results.– Implementations steps of Depression management physi-
Rashdi1 cian Oder It is evidence-based setting up psychiatric therapeutic
1 Oman Medical Speciality Board, Psychiatry, Muscat, Oman; 2 Sultan
guidelines at the most prominent hospital a mental hospital at Min-
Qaboos University Hospital, Department of Behavioural Medicine, istry of Health in Kingdom of Saudi Arabia. The guidelines based on
Muscat, Oman; 3 Sultan Qaboos University Hospital, Rheumatology evidence based on American psychiatric society recommendations.
Unit, Muscat, Oman; 4 Oman Medical Speciality Board, Studies and It designed through pharmacy task force team and headed by the
Research Section, Muscat, Oman author. The guidelines implemented through several educational
sessions with hospital staff. The manual physician order sent to
Background and aims.– There is ample evidence to suggest that information technology to convert as electronic physicians order
physical illness tend to impact on mental disorder and conversely entry
mental disorder affect physical illness. There is a death of studies Conclusions.– The depression management therapy physician order
examine such link in societies in transition such as those in Oman. is a new initiative program at the Mental hospital of Ministry
This study aims to determine the prevalence of depression and anx- of health in Saudi Arabia. The new project may prevent the
iety among patients attending a rheumatology clinic in a tertiary drug-related problem and prevent economic burden in Healthcare
care hospital in Oman. Related aims are to tease out the contribu- system.
tion of demographic and clinical characteristics to the development Disclosure of interest.– The authors have not supplied a conflict of
of depression and anxiety. interest statement.
Methods.– A cross-sectional study was conducted among atten-
dees (n = 103) seeking consultation from a rheumatic unit.
Depressive symptom and anxiety were assessed using Patient
Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disor-
der (GAD-7) respectively. Data regarding demographic and clinical
characteristics of respondents were collected.
E-PP0412 this matter and these studies ignore the final outcome of the early
Comparison of the affective lability non-improvers.
AIMS: to assess prospectively the predictive value symptom-
and temperament characteristics
responsiveness in major depression after 2-week antidepressant
between depressive patients with and treatment.
without mixed features Methods.– A 6-week longitudinal single-blind design was used. In-
K. Altinbas1* , H.I. Tas2 and-outpatients with moderate-to-severe unipolar major depres-
1 Selcuk University Faculty of Medicine, Psychiatry- Mazhar Osman sion episode (U-MDE) (DSM-IV criteria) assessed by 17-item-HDRS
Mood Clinic, Konya, Turkey; 2 Canakkale Onsekiz Mart University aged 18–70 years received protocolized antidepressant treatment
Faculty of Medicine, Psychiatry, Canakkale, Turkey according to baseline severity5 . Clinical severity (HDRS) was mon-
itored at baseline and at 2, 4, and 6-weeks by raters blind to
the treatment option. “Improvers” were those presenting a ≥25%
Background and aims.– Mixed features specifier has been intro-
reduction in HDRS-score at baseline. Efficacy analyses focused on
duced in the latest version of the Diagnostic and Statistical Manual
6-week outcome comparing 2-week improvers and 2-week non-
of Mental Disorders (DSM-5). However, characteristics of mixed
improvers. Recruitment period was February/2007-January/2018.
depression has been argued for many years even before DSM-
Results.– 618 patients were finally included. All 2-week improvers
5. Here, we aimed to evaluate emotion regulation and affective
showed significantly better outcome at 6-week evaluation in
temperament among depressive patients with and without mixed
comparison to the 2-week non-improvers, regardless of the
symptoms.
antidepressant subgroup. Interestingly, more than 80% of 2-week
Methods.– Patient with major depression (n = 63) who were not
non-improvers were full responders (≥50% reduction in HDRS-
on a treatment recruited for the study. Hamilton Depression Rat-
baseline-score) or remitters (HDRS < 8) at 6-week endpoint.
ing Scale (HDRS), modified Hypomania Checklist-32 (mHCL-32),
Conclusions.–
Difficulties in Emotion Adjustment Scale (DDSS) and Affective Tem-
- 2-week antidepressant responsiveness does not provide enough
perament Scale (TEMPS-A) were applied to the participants. The
information to make therapeutic decisions in patients with
collected data were evaluated with Statistical Program for Social
moderate-to-severe U-MDE.
Sciences (SPSS) version 20.
- Responsiveness after two weeks of antidepressant treatment
Results.– Proportion of the mixed depression was 23.8% (n = 15).
could be suggested as a prognostic factor.
There was no significant difference between patients with and
- A high proportion of 2-week non-improvers end up being full
without mixed depression in terms of gender, age, family history,
responders or remitters at 6-week-endpoint.
number of disease onset, total episode and temperament scores.
Non-acceptance subscale scores of DDSS was significantly higher
interest statement.
in mixed depression group (p = 0.035). Correlation and regression
analysis revealed that cyclothymic temperament scores was sig-
nificantly associated with mHCL-32 scores which is related with E-PP0414
mixity in depression (p = 0.024). The effect of an educational
Conclusions.– Mixed features in depression is not rare as we found
that one five of the patients had hypomanic symptoms during
intervention based on
depressive episode. The association between cyclothymic temper- gerotranscendence theory on
ament scores and mixed symptoms is in line with the idea that depression among
temperamental features are subclinic forms of mood disorders. community-dwelling older adults: a
Considering the higher non-acceptence scores and cyclothmiyc randomized controlled trial
temperament scores in mixed depression, it could be concluded S. Asiri1* , M. Foroughan2 , M. Rassouli3 , A. Montazeri4
that mixed depression rely between pure depression and bipolar- 1 Guilan University of Medical Sciences, Community Health, Rasht,
ity. However, further prospective bigger sample sized studies are Iran; 2 University of Social Walfareand Rehabilitation Sciences,
required. Gerontology, Tehran, Iran; 3 Shahid Beheshti University of Medical
Disclosure of interest.– The authors have not supplied a conflict of Sciences, Cancer Research Center, Rasht, Iran; 4 Academic Center of
interest statement. Education, Culture and Research, Iranian Institute for Health Sciences
Research, Tehran, Iran
E-PP0413
Predictive value of 2-week Background and aims.– Depression is one of the most common
antidepressant responsiveness in mental disorders in older adults. Gerotranscendence theory is a
major depression: a 6-week positive view of aging, stating that human development is a pro-
cess that continues into old age, and achieving it can lead to a better
longitudinal single-blind study
acceptance of the aging changes, and reduce depression. The pur-
G. Anmella Diaz1* , I. Boulahfa2 , A. Obach1 , J. Guarch3 , J. Pinzon1 , A.
pose of this study was to determine the effect of an educational
Gimenez1 , V. Navarro3
1 Hospital Clínic of Barcelona, Barcelona, Catalonia, Spain, intervention based on the Gerotranscendence theory on reducing
depression symptoms of community-dwelling older adults.
Department of Psychiatry and Psychology, Barcelona, Spain; 2 Parc
Methods.– An educational intervention designed based on Gero-
Sanitari Sant Joan de Déu, Research, Innovation and Teaching Unit,
transcendence theory was performed as a clinical trial on 26
Sant Boi de Llobregat Barcelona, Spain; 3 Hospital Clinic of Barcelona,
community-dwelling older adults. Participants were randomly
IDIBAPS, CIBERSAM, Department of Psychiatry and Clinical
allocated to the two intervention and control groups. The inter-
Psychology, Barcelona, Spain
* Corresponding author. vention group participated in six 90-minute weekly sessions. The
pre-test and post-test was performed one week before and one
Background and aims.– Unipolar-Depression Clinical-Guidelines week after the intervention by completing demographic informa-
clearly recommend a minimum of 4–6 weeks of antidepressant tion, and geriatric depression questionnaires. Chi-square, Fisher’s
treatment in therapeutic doses in order to assess antidepressant exact test, independent t-test, Mann–Whitney, Wilcoxon, ANCOVA
efficacy. In contrast, various post-hoc analyses of clinical trials sug- and regression tests were used to describe and analyze the data.
gest that improvement at 2-weeks could be a predictor of response. Results.– A significant difference was found between the two groups
Scarce evidence has been provided in prospective assessment in in terms of the mean score (P = 0.001) and level of depression
(P = 0.011) after the intervention. Regression model, for control- Background and aims.– Previous studies have demonstrated predic-
ling the demographic and confounding variables showed that the tive efficacy of early change of prefrontal theta cordance and there
effect of the educational intervention (P = 0.038) and pre-test score are some findings on association of baseline occipital alpha asym-
(P = 0.015) were significant. metry and change of depressive symptoms in depressive patients.
Conclusions.– The results showed that the educational intervention The aim of analysis was to evaluate and compare predictive effi-
based on Gerotranscendence theory significantly reduced the mean cacy of changes of occipital alpha asymmetry (OAAC) and prefrontal
score and level of depression. The practical application of this the- theta cordance (PFCC) after the 1st week of treatment.
ory can help prevent and reduce depression symptoms in older Methods.– All patients (n = 46) were treated with SNRIs (venlafax-
adults. ine, milnacipran) for ≥4 weeks. EEGs were performed at baseline
Disclosure of interest.– The authors have not supplied a conflict of and week 1. Depressive symptoms were evaluated using MADRS at
interest statement. baseline, week 1 and the end of treatment.
Results.– Twenty-three (50%) patients responded to treatment.
PFCC and OAAC were identified as predictors of response to SNRIs.
E-PP0415 Comparing values of AUC of ROC analyses of OAAC, PFCC and
Risk of perinatal depression in men model combining OAAC and PFCC we did not find significant
and women in a public hospital in differences–for details (AUC, predictive values) - Table 1.
North Greece Table 1. Prediction of response to SNRIS
A. Bompoli1 , K. Argyropoulos2 , D. Avramidis3* , E. Jelastopulu2
1 Frederick University of Cyprus, Health Management, Nicosia, Parameter AUC (95% CI) PPV (95% CI) NPV (95% CI)
Cyprus; 2 University of Patras, Public Health, Patras, Greece; 3
PFCC 0.82 (0.68–0.92) 0.74 (0.60–0.84) 0.84 (0.64–0.94)
University of Patras, Medical School, Patras, Greece OAAC 0.73 (0.58–0.85) 0.67 (0.56–0.76) 0.92 (0.63–0.99)
PFCC + OAAC 0.88 (0.75–0.96) 0.86 (0.68–0.95) 0.83 (0.67–0.93)
model
Background and aims.– Perinatal depression is a frequent psychi-
atric disorder in women during and after pregnancy. However,
Conclusions.– The predictive efficacy of early changes of PFCC,
perinatal depression can affect men too. The aim of the present
OACC and model both parameters was comparable. This study was
study was to investigate the risk of perinatal depression in both
supported by the grants of MH CR nr.15-29900A, MH CZ - DRO
women and men, at the General Hospital of Veria, North-Greece,
(NIMH-CZ, 00023752) and the project Nr. LO1611 from the MEYS
and to examine the associations with various risk factors.
under the NPU I program. No other conflicts of interests.
Methods.– A cross-sectional study was conducted in a sample of
60 consecutive mothers that were hospitalized in 2017–2018 in
interest statement.
the Obstetrics Department, together with their partners. Data were
collected using the Greek version of Edinburgh Postnatal Depres-
sion Scale (EPDS), before and after partum. Men answered the EPDS E-PP0417
before partum. EPDS score above 11 was considered as risk of ate-
Psychiatric and cognitive disorders in
natal or postnatal depression.
Results.– In women, the mean EPDS score before partum was 10.5 LRRK2-G2019S Parkinson’s disease
and after partum 14.1 (p < 0.05) and in men 9.5 before partum. The S. Ben Romdhan1* , N. Farhat1 , A. Nasri2 , M. Damak3 , R. Gouider4 ,
overll prevalence of peritnatal depression in women was 46,7% C. Mhiri3
1 Laboratory of Neurogenetics, Parkinson’s Disease and
before and 70% after partum. In men a prevalence of 30% was
observed. The EPDS scores in women were significantly associ- Cerebrovascular Disease, University Hospital Habib Bourguiba, Sfax,
ated with residency, education, relations with parents and partner, Tunisia, Neurology, Sfax, Tunisia; 2 Department of Neurology
psychological problems and medications, previous abortion and University Hospital Razi-Mannouba, Tunisia, Department of
complications during partum, whereas in men the associated factos Neurology University Hospital Razi-Mannouba, Tunisia; 3 Laboratory
were family status, education, relations with parents and partner of Neurogenetics, Parkinson’s Disease and Cerebrovascular Disease,
and psychological problems. University Hospital Habib Bourguiba, Sfax, Tunisia, Laboratory of
Conclusions.– Women are experiencing high percentages of post- Neurogenetics, Parkinson’s Disease and Cerebrovascular Disease,
natal depression, but also one in 3–4 men show symptoms of University Hospital Habib Bourguiba, Sfax, Tunisia; 4 Department of
depression. Thus, postnatal depression should not be seen as explic- Neurology University Hospital Razi-Mannouba, Tunisia, Department
itly maternal and both, mothers and fathers should be routinely of Neurology University Hospital Razi-Mannouba, Tunisia, Sfax,
screened and get emotional and practical help. Tunisia
interest statement.
Background and aims.– The LRRK2-G2019S mutation is the most
common cause of Parkinson’s disease (PD) in North Africa. G2019S-
PD has been described as similar to idiopathic with minor clinical
E-PP0416
differences.
The early changes of occipital alpha The aim of this study was to compare cognitive and psychiatric
asymmetry and prefrontal theta disorders between G2019S-carriers and non-carriers.
cordance in the prediction of response Methods.– our study included 107 G2019S-carriers and 119 non-
to SNRIs carriers. Patients were enrolled in the study regardless of their
M. Bares1,2* , T. Novak1 , P. Vlcek3 , M. Hejzlar1 , M. Brunovsky3 familial history of PD, age at examination and age at onset. The mini-
1 National Institute of Mental Health Czech Republic, Clinical mental state examination (MMSE) was used to measure the degree
Division, Klecany, Czech Republic; 2 Third Faculty of Medicine, Charles of cognitive impairment according to educational attainment. Any
University, Department of Psychiatry and Medical Psychology, MMSE score higher than or equal to 21 for middle school (<6 years),
Prague, Czech Republic; 3 National Institute of Mental Health Czech 23 for high school (6–13 years), and 24 for university/graduate
Republic, Applied Brain Electrophysiology, Klecany, Czech Republic attainment (>13 years) was considered as normal. Beck’s Depres-
* Corresponding author. sion Inventory was used to evaluate mood disturbance and detect
depression. Adult out-patients with a score higher than or equal
to 20 were considered as severely depressed. Logistic regression

models were used to compare clinical features between the studied
groups.
Results.– Adjusted for age, sex, disease duration, levodopa-
equivalent dose and educational level, MMSE scores were
significantly higher (adjust-p = 0.019) in the G2019S-carriers than
non-carriers. Also men had higher level of education, better cogni-
tion (adjust-p-value for educational level = 0.042) and less tendency
towards depression than females (adjust-p = 0.046).
Conclusions.– In this study, G2019S-PD patients showed better
performance on the MMSE test compared with iPD. Cognitive
impairment and depression were less common in G2019S male
carriers compared with females.
interest statement.
E-PP0418
SPECT: complementary tool in
diagnosis and follow-up in depressive
pseudodementia
S. Boi1* , B. Sanz-Aranguez Avila1 , P. Maguilla Franco1 , J. Herranz
Herrer1 , L. Gayubo Moreo1 , F.J. De Haro Del Moral2
1 Hospital Puerta de Hierro, Psychiatry, Majadahonda, Spain; 2
Hospital Puerta de Hierro, Nuclear Medicine, Majadahonda, Spain

Background and aims.– Dementia and depressive disorder are

neuropsychiatric conditions that often coexist and whose symp-
tomatology frequently overlaps and a precise differential diagnosis
Figure 1. Depressive pseudodementia.
is often challenging. Functional neuroimaging shows a promising
tool to differentiate them. Conclusions.– SPECT could be a useful tool for the differential diag-
Methods.– We present a case report of a 48 years old male nosis between cognitive dysfunction and pseudodementia. Control
with several depressive disorder hospital admissions refractory SPECT after treatment could add strength to differential diagnosis
to multiple antidepressants and, who develops cognitive dysfunc- due to possible gradual perfusion improvement after treatment in
tion, also identified in functional neuroimaging. We objectified depression whereas in cognitive dysfunction we could see a wors-
depressive symptomatology, high levels of anxiety, reitera- ening. Until this date there is no clinical trial available that uses
tive speech, mnemonic mistakes and regressive behaviour and SPECT in depression and dementia differential diagnosis. We found
assistance needs in basic activities such as hygiene and feed- relevant the simultaneous depressive symptomatology improve-
ing. Clinical remission was achieved lately, with SPECT results ment and perfusion pattern normalization.
normalization. Disclosure of interest.– The authors have not supplied a conflict of
Results.– Initial SPECT showed extensive alterations principally at interest statement.
frontal and temporal regions suitables with dysthymia, without
dismissing DFT. After a month with psychopharmacological treat-
ment it was seen an improvement in depressive symptomatology, E-PP0419
with disappearance of regressive behaviour and cognitive dys- Post stroke psychiatric disorders: a
function, which was confirmed by the control SPECT where global prospective study
perfusion progress was shown. (figure 1) A. Bouhamed* , O. Hdiji, I. Bouchhima, N. Farhat, H. Hadj Kacem, S.
Sakka, M. Dammak, C. Mhiri
Neurology Department, Habib Bourguiba Hospital, Sfax, Tunisia
Background and aims.– The first 6 months after stroke are a time in
which a person is highly vulnerable to develop these psychiatric
conditions. We discuss the different psychiatric manifestations
occurring after an arterial stroke in a series of patients followed
in our department.
Methods.– Our study is prospective, including patients consulting
for a stroke or transient ischemic attack (TIA), over a period of
10 months (November 2008–August 2009) with a follow-up of 6
months. We used the Hamilton and HAD (Hospital anxiety and
depression scale) respectively as the means of diagnosis for depres-
sion and anxiety.
Results.– Our series contained 65 patients with an average age of
67.6 ± 14.2 years. We reported 48 ischemic stroke,10 hemorrhagic
stroke and 7 TIA. Psychiatric complications were present in 20% of
cases (13/65 patients). Depression and anxiety were the most fre-
quent, observed respectively in 10 and 8/13 patients. They were
associated in 75% of cases. Only one patient presented a confusion E-PP0421

in the 2nd month without apparent cause. These psychiatric disor- Inflammation and remission of
ders predominated in ischemic stroke. The mean time to onset of
depression in patients treated with
depression and anxiety was respectively 54.6 and 38 days. Anxiety
was more common than depression during the first week. In the fol-
electroconvulsive therapy; findings
lowing weeks, depression predominate. Stroke was severe in 70% from the modect study
of depression cases (initial NIHSS score >13). Antidepressant treat- A. Carlier1,2* , J. Berkhof1 , F. Bouckaert3,4 , P. Sienaert4 , P.
ment was initiated in 7 cases. Eight patients showed improvement Eikelenboom1 , R. Veerhuis5 , M. Vandenbulcke3 , J. Berkhof6 , M.
in depressive symptoms. Stek1,2 , D. Rhebergen1,2 , A. Dols1,2 , E. Exel1,2
1 GGZ inGeest, Department of Old Age Psychiatry, Amsterdam, The
Conclusions.– The clinician must screen and recognize these psy-
chiatric symptoms for any progression on every follow up visit Netherlands; 2 Amsterdam UMC, Amsterdam Public Health Research
especially within first 6 months as this is time with extreme vulner- Institute and Neuroscience, Amsterdam, The Netherlands; 3
ability to develop psychotic symptoms. Neurology and psychiatry University Psychiatric Centre KU Leuven, Department of Old Age
should work in collaboration to address these neuropsychiatric Psychiatry, Leuven, Belgium; 4 University Psychiatric Centre KU
phenomena. Leuven, Academic Center for ECT and Neuromodulation, Leuven,
Disclosure of interest.– The authors have not supplied a conflict of Belgium; 5 Amsterdam UMC, Clinical Chemistry Department,
interest statement. Amsterdam, The Netherlands; 6 Amsterdam UMC, Department of
Epidemiology & Biostatistics, Amsterdam, The Netherlands
E-PP0420
Background and aims.– Compelling evidence links elevated C-
Trace elements differences in the reactive protein (CRP) and other inflammatory markers to a poor
depression sensitive and resilient treatment outcome to antidepressant medication.
chronic unpredictable mild stress rat Aim.– To test if low-grade inflammation, i.e. moderately elevated
models CRP levels (3 to 10 mg/L), contributes to a poor treatment outcome
B. Cao1* , L. Yan1 , Y. Chen2 , J. Wang1 in severely depressed patients treated with Electroconvulsive Ther-
1 Peking University, School of Public Health, Beijing, China; 2 apy (ECT).
University of Toronto, Dalla Lana School of Public Health, Toronto, Methods.– Associations between serum levels of CRP, Interleukin-
Canada 6, Interleukin-10, Tumour Necrosis Factor-␣, and remission of
* Corresponding author. depression, time to remission and speed of decline of depressive
symptoms, were examined in 95 unipolar depressed patients (age
Background and aims.– Depressive disorders are the leading cause ≥55 years, 68.4% women) treated with ECT.
of disability worldwide; however, the etiology and pathophys- Results.– Moderately elevated levels of CRP at baseline, but no
iology behind the diseases remain unclear. Increasing evidence other inflammatory markers were associated with higher remission
has demonstrated that trace elements may play important roles rates. Odds ratio for remission, in those with moderately elevated
in depressive symptoms. Altered levels of several trace elements, CRP levels was 3.62 (95% confidence interval [CI], 1.09–11.97;
such as zinc, magnesium, iron, calcium, selenium and chromium p = 0.04). Time to remission was shorter in those with moderately
are associated with mental diseases by affecting the N-Methyl- elevated CRP levels, p = 0.05. Speed of decline was higher in those
d-aspartic Acid (NMDA) receptors in several brain parts and patients with moderately elevated CRP levels as compared to those
antioxidant capacity. with low CRP levels (decline of 3.2 MADRS points per treatment
Methods.– Our current study used a Chronic Unpredictable Mild session vs. 2.3 points per session, p = 0.03).
Stress (CUMS) model to simulate social pressure in rat model and Conclusions.– Whereas earlier studies show that low-grade inflam-
compared the levels of 20 trace elements in the plasma and brain, mation contributes to poor treatment response in those treated
within and between groups. 35 adult male rats (Control group: 14; with antidepressants, our study provides clues that low-grade
CUMS group: 21) were included for detection. We used sucrose inflammation does not have such a detrimental effect on the treat-
preference reductions as the indicator of depression severity. ment response to ECT. This is underscored by our finding that
Results.– In the CUMS model, 57% (12 in 21) of rats showed no moderately elevated CRP levels were associated with increased
significant decrease in sucrose preference and were grouped as remission rates of depression and a higher speed of decline in
CUMS-resilient; otherwise, CUMS-sensitive. The resilient group has MADRS scores in patients treated with ECT.
higher levels of iron, sodium, sulfur, manganese and cobalt than Disclosure of interest.– The authors have not supplied a conflict of
the sensitive group in the brain samples. The sensitive group has interest statement.
lower levels of calcium, potassium, sulfur, selenium and cobalt
than the resilient groups, in the plasma samples. Zinc, magnesium,
calcium, selenium and chromium had the similar positive trend E-PP0422
among groups both in the brain and plasma samples while iron Botulinum toxin for the treatment of
had the opposite trend.
resistant depressive disorder.
Conclusions.– The higher levels of iron, calcium, selenium, man-
ganese and cobalt in the resilient group indicated these trace Comparison of two facial injection
elements might be protective against the development of depres- sites
sive symptoms in response to stress. C. Ceolato1 , E. Charles1* , G. Gallouedec2 , J.P. Clement1 , D. Ranoux3
1 CH Esquirol, UCER Paul Mondain, Limoges, France; 2 CHU
interest statement. Dupuytren, Neurology, Limoges, France; 3 CHU Dupuytren,
Neurosurgery, Limoges, France
Background and aims.– Introduction: In the last decade, 3

randomized, placebo-controlled studies have suggested that
OnabotulinumtoxinA (OnaA) into glabellar muscles could be a safe
and effective treatment for resistant depressive disorder.
Objective.– To confirm or infirm previous results, using another Disclosure of interest.– The authors have not supplied a conflict of
methodology. interest statement.
Methods.– Single blind, randomized trial. All patients received OnaA
injections, and were randomly assigned to two sites of injection,
either glabellar or crow’s feet area. Patients did not know which E-PP0424
site was thought to be efficacious. Patients of the “glabella” group Investigating the presence of
received injections into the procerus and both corrugator (5 units depressive symptoms among students
each). Patients of the “crow’s feet” group were injected into the
with type D personality
orbicularis oculi (15 units in three sites on each side). We have
M. Csibi1* , S. Csibi2 , M.D. Pasca2 , M. Gabos Grecu2
planned to include 58 patients. Here, we present the preliminary 1 University of Medicine and Pharmacy Tg.Mures, Hygiene, Tg.Mures,
results in the 23 first patients. The primary outcome measures were
Romania; 2 University of Medicine and Pharmacy Tg.Mures, Ethics
the changes from baseline in MADRS score at 6 weeks.
and Social Sciences, Tg.Mures, Romania
Results.– Scores on the MADRS dropped of 57,6% in the “glabellar” * Corresponding author.
group versus 36% in the “crow’s feet” group (p = 0.004). We also
found a significant change in most of the secondary endpoints: Background and aims.– In the biopsychosocial approach, the medi-
number of responders (p < 0.01), EGF score (p = 0,004), CGI score cal act targets the individual, along with its biological, psychological
(p = 0,037). We observed no adverse events. and social characteristics. Getting to know the patient becomes
Conclusions.– Using a different methodology, these preliminary primordial for treatment, the manifestation of a disease being
results support the view that OnaA into the glabellar muscles may influenced by individual experiences and personality. The type D
be a safe and effective treatment for resistant depressive disorder. personality proves relevant associations with an increased vulnera-
We suggest that OnaA may act as a neuromodulator of the mirror bility toward various diseases and related psychological difficulties.
neurons system by reducing the motor input to the premotor area. The study aims to identify the existing association between the type
Disclosure of interest.– The authors have not supplied a conflict of D personality and depressive symptoms, controlling for gender.
interest statement. Methods.– Participants were 445 students from the 18–25 age
group. An online questionnaire was uploaded to the Qualtrics XM
E-PP0423 Platform, collecting demographic data (age, sex, year of study),
responses to the D-type Personality Questionnaire (DS 14, Denollet,
Functional recovery in remitted 2005) and reports on the presence of depressive symptoms (Patient
patients treated for major depressive Health Questionnaire-9, Kroenke, Spitzer and William, 2001).
disorder (MDD) in routine clinical Results.– In our sample, the prevalence of D-type personality was
practice in Greece 30.7%, both the prevalence of type D personality and reported
A. Chatzimanolis1* , N. Avgerinos1 , D. Dimellis2 , D. Pappas1 , I. symptoms of depression was significantly higher among female
Genaris2 , T. Mylonaki1 , E. Papalexi3 students. Participants with higher scores on Type D personal-
1 Psychiatrist, Medical Office, Athens, Greece; 2 Psychiatrist, Medical ity scale reported more depressive symptoms, such as suicidal
Office, Thessaloniki, Greece; 3 Lundbeck Hellas, Medical Department, thoughts, intense feelings of concern/guilt, sadness, loss of interest,
Athens, Greece concentration problems, weight changes or appetite modifications.
* Corresponding author. Conclusions.– The study brings evidence regarding the type D
personality’ s predictive role in the occurrence of depressive symp-
Background and aims.– Almost half of the patients who meet toms. The results are useful for specialists treating patients with
symptom-based definitions of remission, as measured by com- different physical or mental diseases and presenting D-type per-
monly used rating scales, although considered as a successful sonality. A better knowledge about the patient’ personality and
treatment outcome, do not consider themselves remitted, expe- propensity toward depressive symptoms can influence the effi-
riencing functional impairment. Determining functional recovery ciency of the treatment.
in domains such as work/school, social and family life based on Disclosure of interest.– The authors have not supplied a conflict of
patients’ ratings thus is an important indicator for the patients’ interest statement.
wellbeing.
The aim of the current study analysis was to assess functional recov-
ery in patients with MDD who have remitted after antidepressant
treatment in clinical practice in Greece and to assess correlations E-Poster Presentation: E-mental Health/Oncology
with mood and cognitive symptoms. and Psychiatry
Methods.– This was a non-interventional, cross-sectional multi-
site study in outpatients with MDD who have clinically responded
to antidepressant treatment. Symptom remission was defined by E-PP0425
MADRS score (MADRS ≤12) and functional recovery was defined by
Sheehan Disability Scale total score (SDS ≤6). Cognitive symptoms
Use of information and
were also assessed using PDQ-D (Perceived Deficits Questionnaire- communication technologies among
Depression). Stepwise multiple linear regression and correlation individuals with and without serious
analysis were applied. mental illness
Results.– 335 patients with MDD participated in the study. 53.7% Z. Abu Rahal1* , L. Vadas2 , B. Bloch2,3 , A. Avital2,3
(n = 198) of the participants were remitted and 40.3% (n = 135) were 1 Clalit Health Services, Psychiatry Department, Northern District,
functionally recovered (SDS ≤6). In the subgroup of remitters, only Israel; 2 Emek Medical Center, Psychiatry Department, Afula, Israel; 3
nearly half of the patient population were functionally recovered Technion–Israel Institute of Technology, Faculty of Medicine, Haifa,
[n = 113, (57%)]. Functional recovery correlated significantly with Israel
MADRS total score (p-value < 0.001, beta-coefficient: −0.155) and * Corresponding author.
with PDQ-D total score (p-value = 0.045, beta-coefficient: −0.039).
Conclusions.– Although patients with MDD in routine clinical prac- Background and aims.– Growing interest surrounds the use of
tice in Greece may have remitted from their symptoms, functional information and communication technologies (ICTs) for mental-
recovery remains an unmet need, linked to both depressive and health-related purposes, yet little is known about rates of ICT use
cognitive symptoms. among the psychiatric population and those with severe mental ill-
ness. This study examines ICT accessibility among the psychiatric Objectives.– To study the efficacy of blended care model, integrat-
population, focusing on serious and non-serious mental illness (SMI ing telemedicine platform and online tools to in-clinic treatment
and non-SMI). protocolsto improve patient recruitment and adherence to therapy.
Methods.– Patients (N = 427) from all service branches of the Psychi- Methods.– The authors studied patient recruitment to the blended
atry Department at Emek Medical Center were recruited orally or treatment program during a 4 month period (Cases), and patients
through advertisement. Respondents completed a self-report sur- receiving traditional models of therapy only with walkin clinic
vey regarding accessibility and use of ICTs (i.e., computer, internet, consultations (Controls) during a comparable time period in the
Facebook, mobile phone, smartphone). calendar year. The modules were studied using measurable quality
Results.– Results revealed that 59.3% of respondents used comput- of care parameters on dimensions of stage of patient recruitment
ers, 77.3% used the internet, 92.7% owned a mobile phone, 68.7% (severity of case at which patient made first contact with doc-
owned a smartphone, and 64% used Facebook. Over half of par- tor) and treatment adherence (measured by patient drop-out from
ticipants who used ICTs reported doing so at least once per day. treatment).
SMI and non-SMI respondents differed significantly in their use Results.– The results were statistically analysed to verify the
and access to a computer, the internet, Facebook, and smartphones hypothesis that blended care models improve outreach to patients
(see Figure 1). and enhance adherence to treatment while maintaining quality of
care.
Conclusions.– The blended care model allows doctors to expand
reach, while providing efficiency in managing patient care. The
incorporation of online tools in treatment plan improved treatment
adherence, and the availability of online data and related analytics
further improved the quality of care provided by doctors. It high-
lighted further research into the impact of the blended care model
on patient outcomes.
interest statement.
E-PP0427
How do patients subjectively
experience electronically delivered
cognitive behavioural therapy (ECBT)?
Qualitative findings and two case
Figure 1. Percentage of information communication technology
reports
(ICT; computer, internet, Facebook, mobile phone, smartphone) use
E. Cindik-Herbrüggen1* , T. Berger2 , T. Krieger2 , B. Meyer3 , H.
and ownership among all participants. Comparison between par-
Riper4 , A. Urech2
ticipants with serious mental illness (SMI) and non-SMI: * < 0.006; 1 Neuro-Psychiatric Centre Riem, Psychiatric, München, Germany; 2
** < 0.0001.
University Bern, Clinical Psychology and Psychotherapy, Bern,
Conclusions.– The findings suggest that mental illness is not a barrier Switzerland; 3 GAIA, Research, Hamburg, Germany; 4 VU University
to using and accessing technology; however, when differentiating Amsterdam, Faculty of Behavioural and Movement Sciences- Section
between SMI and non-SMI, illness severity is a barrier to poten- of Clinical Psychology, Amsterdam- Netherlands, Netherlands Antilles
tial ICT utilization. These results may encourage policy makers to
design ICTs that suit the needs of individuals with SMI.
Background and aims.– Electronically delivered cognitive
behavioural therapy (eCBT) for depression is often regarded
interest statement.
as an efficient treatment tool to augment antidepressant medica-
tion or face-to-face (FtF) CBT. Indeed, meta-analyses have shown
E-PP0426 that some eCBT interventions are effective, although they differ in
content and efficacy. Little is known, however, about the subjective
Efficacy of blended care models experiences of patients using eCBT. The aim was to illuminate how
(virtual/telepsychiatry combined with patients subjectively experience the eCBT intervention deprexis,
inclinic consultations) in treating which has been shown to be effective in 12 RCTs.
psychiatric illnesses in a developing Methods.– Findings from a recent qualitative analysis are presented,
economy; a study of psychiatrists in in which patients were interviewed about advantages and disad-
vantages of using deprexis (Urech et al., 2018). Additionally, two
India case examples are presented.
A.I. Ahmed1* , A. Sinha2 , A. Choudhury1 , G. Sharma3 , H. Nirankari
Results.– Qualitative analyses showed that many patients expe-
Singh2
1 PsyCare Neuropsychiatry Care Center, Psychiatry, New Delhi, India; rience deprexis as a valuable addition to treatment, and that its
2 Wayuhealth, Software Development, Gurgaon, India; 3 PsyCare flexibility and constant availability are perceived as distinct advan-
tages. Some contact with a clinician is also regarded as important,
Neuropsychiatry Care Center, Psychology, New Delhi, India
* Corresponding author. as it provides a sense of security and facilitates motivation. In the
first case example, a 58-year-old man who had become depressed
Background and aims.– India has an acute shortage of qualified men- after recent job loss found it difficult to engage with deprexis. This
tal health professionals, with only 6000 psychiatrists for a nation of improved, however, when the therapist gently prompted him to
1.4Billion people. With this shortage of mental health professionals complete eCBT modules and bring print-outs to sessions. In the
with barriers to access, and a large disease burden of 7.5% of pop- second example, a 38-year-old woman with anorexia nervosa and
ulation it is imperative to explore models that allow doctors to see comorbid depression engaged daily with deprexis; her intensive
more patients while maintaining the quality of care. desire for support could not be satisfied by F2F therapy alone.
Conclusions.– These qualitative findings can help clinicians under- Methods.– Data were collected using a self-administered ques-
stand which factors may influence the success of using eCBT as a tionnaire including demographic information, risk factors and
treatment tool. consequences of violence. Quality of life was estimated using a
Disclosure of interest.– The authors have not supplied a conflict of standardized mental health questionnaire from Goldberg’s General
interest statement. Health Questionnaire (GHQ12).
Results.– A total of 133 participants (response rate 88.6%): 64.5%
nurses, 25.5% doctors, 7.3% versatile workers and 2.7% administra-
E-PP0428 tive staff. The majority (70.9%) were female. The population was
Adherence predictors in an exposed to physical (36.4%) and non-physical (67.3%) assaults. The
internet-based intervention program actors of violence were mainly visitors (68.2%) and patients (31.8%).
The limited number of staff (63.3%) and lack of materials (43.3%)
for depression
were the main reasons for WPV. Violence has considerable conse-
M. Gili Planas1* , M. Roca2 , A. García-Palacios3 , J. García-Campayo4 ,
quences on workers’ well-being, patient care, and job performance.
R.M. Baños5 , C. Botella3 , F. Mayoral6 , M.A. Perez-Ara2 , A. Seguí2 , A.
Among respondents, 55% reported immediately high levels of stress
Castro2
1 IUNICS-IDISBA, Psychology, Palma de Mallorca, Spain; 2 University and 50% reported fear and insecurity feeling. Later, 43.3% of the
participants expressed exhaustion and 38.3% reported anxiety. Psy-
of Balearic Islands, IUNICS-IdisBA, Palma de Mallorca, Spain; 3
chological distress was noted in 53.6% of cases.
University Jaume I, Faculty of Health Sciences, Castellón, Spain; 4
Conclusions.– WPV is prevalent among healthcare staff, and several
Hospital Miguel Servet, Department of Psychiatry, Zaragoza, Spain; 5
complex factors are associated with a greater risk of such violence,
University of Valencia, Department of Psychological, Personality,
including work setting, and work environment. We recommend
Evaluation and Treatment, Valencia, Spain; 6 Institute of Biomedicine
that leaders provide and enhance education and support for high-
of Málaga, University Regional Hospital of Málaga, Málaga, Spain
* Corresponding author. risk groups to help and protect them from workplace violence.
Background and aims.– Internet-delivered psychotherapy has been interest statement.
demonstrated to be effective in the treatment of depression. Nev-
ertheless the study of the adherence in this type of the treatment
reported divergent results. The main objective of this study is to E-PP0430
analyze predictors of adherence in a primary care Internet-based Evaluation of a blended CBT platform
intervention for depression in Spain. for depression through mixed
Methods.– A multi-center, three arm, parallel, randomized con- methods: a clinical trial and
trolled trial was conducted with 194 depressive patients, who were
qualitative evaluation from
allocated in self-guided or supported-guided intervention. Sociode-
mographic and clinical characteristics were assessed using a case psychotherapists
report form. The Mini International Neuropsychiatric Interview J.B. Hazo1* , J. Holztmann2 , M. Michel3 , C. Picot-Ngo4 , M. Dorsey5 ,
(MINI) diagnoses major depression. Beck Depression Inventory was A. Prigent3 , K. Chevreul5
1 INSERM ECEVE, UMRS-1123 ECEVE, Paris, France; 2 FondaMental
used to evaluate depression severity. The visual analogic scale
assesses the respondent’s self-rated health and Short Form Health Advanced Centers of Expertise in Resistant Depression FACE-RD, CHU
Survey was used to measure the health-related quality of life. Grenoble, Grenoble, France; 3 AP-HP, Urc Eco, Paris, France; 4
Results.– Age results a predictor adherence for both intervention INSERM, UMRS 1123 Eceve, Paris, France; 5 INSERM, UMRS-1123
groups (with and without therapist support). Perceived health is a Eceve, Paris, France
negative adherence predictor for the self-guided intervention when
change in depression severity was included in the model. Change in
Background and aims.– As part of the E-COMPARED project, we
depression severity results a predictor of adherence in the support- ®
conducted an experiment on the Moodbuster platform which pro-
guided intervention.
vides web-based cognitivo-behavioural therapy (CBT) modules for
Conclusions.– In our sample there are specific adherence predic-
major depressive disorder. These modules are blended with face-
tors in each intervention condition of this Internet based program
to-face CBT sessions. Our first aim was to assess the clinical and
for depression (self-guided and support-guided). It is important to
cost-effectiveness of such blended CBT compared to traditional CBT.
point that further research in this area is essential to improve tai-
The second objective was to analyse professional feedbacks about
lored interventions and to know specific patients groups can benefit ®
from these interventions. blended therapy in general and Moodbuster in particular, of the
Disclosure of interest.– The authors have not supplied a conflict of therapists involved in the project.
interest statement. Methods.– A two-arm randomized controlled trial was carried out in
10 specialized major depression centres. Adult patients who meet
DSM-IV criteria for MDD were included either in the blended CBT
®
E-PP0429 arm, mixing 8 face-to-face sessions with Moodbuster modules, or
Mental health consequences of in the control group, consisting in 18 sessions of face-to-face CBT.
The depressive symptoms, quality of life and healthcare consump-
exogenous violence against tion information have been taken at baseline, post-treatment and
healthcare professionals 12 months.
Z. Hakim* , N. kotti, S. imen, F. amen, J.H. kaouthar, M. mohamed 10 therapists involved in both arms of the protocol were inter-
larbi, H. mounira viewed afterward with a semi-structured interview grid. Their
Hedi Chaker Hospital, Occupational Medicine, Sfax, Tunisia answers were thematically categorised and analysed by two
Background and aims.– researchers.
Introduction.– Workplace violence (WPV) is very common and leads Results.– Quantitative analyses showed either inferiority or non-
to a series of adverse results. inferiority of blended CBT vs traditional one in terms of cost and
Objective.– This study addresses the characteristics, associated risk clinical effectiveness, depending of the outcome and time of mea-
factors, and consequences of exogenous WPV against workers in surement.
two public hospitals in Tunisia. Qualitative results provide the advantages, limiting factors and per-
spectives of improvement of blended CBT.
®
Conclusions.– As designed in Moodbuster and in this trial, blended E-PP0432
CBT seems not as efficient as face-to-face therapy for major depres- Time spent on social media as a
sive disorder but consideration of feedbacks from therapists and, predictor of the level of anxiety and
in the future, users, are prone to improve their results.
depression in Albanian university
interest statement. students
K. Kola1* , F. Elezi2
1 Resident in General Psychiatry, University Hospital Center of Tirana
E-PP0431 ‘Mother Theresa’, Neuroscience Department, Psychiatric Service,
Tirana, Albania; 2 Head of Emergency Psychiatry Unit, University
Attitudes of professionals from South
Hospital Center of Tirana ‘Mother Theresa’, Neuroscience
Eastern Europe toward dialog+ Department, Psychiatric Service, Tirana, Albania
psychosocial intervention for patients * Corresponding author.
with psychosis–short survey

S. Jerotic1* , M. Milutinovic2 , T. Radojicic3 , T. Pemovska4 , I. Ristic1 , Background and aims.– Social media have become an ever-
L. Novotni2 , S. Repisti3 , L. Injac Stevovic5 , A. Novotni6 , N.P. Maric7 , increasing part of our lives. With the progress of technology and
N. Jovanovic4 the widespread use of smartphones, people are spending more time
1 Faculty of Medicine, University of Belgrade, Psychiatry, Belgrade, on their screens. This has sparked the interest of many researchers,
Serbia; 2 Faculty of Medicine Ss Cyril and Methodius, University of resulting with a wide variety of studies conducted on this topic.
Skopje, Psychiatry, Skopje, FYR Macedonia; 3 Clinic for Psychiatry, This study aims at investigating the following variables among
Clinical Centre of Montenegro, Psychiatry, Podgorica, Montenegro; 4 Albanian students:
Queen Mary University of London, Unit for Social and Community The predictive value that time spent on social media has on anxiety
Psychiatry, WHO Collaborating Centre for Mental Health Services and depression.
Development, London, United Kingdom; 5 School of Medicine, The correlation between the levels of anxiety, depression and time
University of Montenegro & Clinic for Psychiatry, Clinical Centre of on social media.
Montenegro, Psychiatry, Podgorica, Montenegro; 6 Faculty of The gender differences in anxiety and depression.
Medicine Ss Cyril and Methodius, University of Skopje & University Methods.– Students (18–30 years old) from ten Albanian Universi-
Clinic of Psychiatry, Skopje, Psychiatry, Skopje, FYR Macedonia; 7 ties were selected through a convenient sampling method during
Faculty of Medicine, University of Belgrade & Clinic for Psychiatry, the period (15th–27th of May, 2017). Questionnaires were admin-
Clinical Centre of Serbia, Psychiatry, Belgrade, Serbia istered online. Data were gathered using PHQ-9 (Patient Health
* Corresponding author. Questionnaire-9) and BAI (Beck Anxiety Inventory).
Results.– Findings suggest a significant positive correlation between
Background and aims.– Technology-assisted and patient-centered depression and anxiety (r = 0.70, N = 664, p = 0.01), depression and
communication based methods could improve routine meetings time on social media (r = 0.45, N = 664, p = 0.00), anxiety and time
between clinicians and patients. DIALOG+, a new intervention on social media (r = 0.29, N = 664, p = 0.01). Time on social media
which effectively structures routine meetings, made them com- has a predictive value for anxiety (t = 20.98, p = 0.01, r2 = 0.09)
prehensive and solution-focused and improved quality of life in and depression (t = 11.78, p = 0.00, r2 = 0.2). The level of depression
persons with psychotic disorders from UK. Psychotic disorders are is predicted by the level of anxiety (t = 12.17, p = 0.01, r2 = 0.47).
one of the major health burden in low- and middle- income coun- Women scored higher levels of anxiety (F(1, 662) = 6.85, p < 0.01),
tries (LMICs), which struggle to overcome funding difficulties and and higher levels of depression (F(1, 662) = 5.66, p = 0.01) compared
lack of qualified staff. However, it is still unknown how local factors to men.
in LMICs could influence implementation and efficacy of methods Conclusions.– Time spent on social media has a predictive value on
such as DIALOG+. the levels of anxiety and depression, and there is a positive rela-
Objective of our survey was to explore a priori assumptions about tionship between the three variables. Females report higher levels
DIALOG+ of mental health professionals from FYR of Macedonia, of anxiety and depression compared to males.
Montenegro and Serbia. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– During the professional meetings with large audi- interest statement.
ence (National Congress/Symposium), the intervention has been
described to the audience by local experts in local language. After
the presentation which lasted for 20–30 minutes, professionals E-PP0433
(with no experience in Dialog+) were invited to answer 8-questions The experience of psychosocial online
survey anonymously, addressing their interest towards Dialog+, an counselling project in Ukraine on
opinion about its applicability and also about the possible obstacles
Ipso-care platform
for the implementation in the local mental health facilities.
V. Korostiy1* , I. Missmahl2 , O. Polishchuk3 , O. Penderetska3 , G.
Results.– On the basis of 182 replies (20 + 46 + 116, respectively),
Krapivnyk4
the first impression about Dialog+ was positive. Dialog+ was differ- 1 Kharkiv National Medical University, Psychiatry, Narcology and
ent in comparison to common practice of participating clinicians.
Medical Psychology, Kharkiv, Ukraine; 2 International Psychosocial
The most of them have shown interest to implement it and found
Organization, Ipso, Berlin, Germany; 3 Bukovina State Medical
this innovation being primarily in favor of patients. As the major
University, Medical Psychology Center, Chernivci, Ukraine; 4 Kharkiv
obstacles clinicians mentioned lack of their time and equipment
National Pedagogical University, Phylology, Kharkiv, Ukraine
acquisition limitations. * Corresponding author.
Conclusions.– This survey could provide meaningful directions for
DIALOG+ implementation in LIMCs. Background and aims.– In the last two years the problem of inter-
Disclosure of interest.– The authors have not supplied a conflict of nally displaced persons has not lost its’ topicality and for Ukraine
interest statement. it has become a new severe challenge.
The aim of the project is to provide professional, accessible, free for
the users and fully anonymous psychosocial online care.
Methods.– Analysis of protocols of online counseling sessions and
supervisions. The online counseling may be used by any person, but
the target audience includes the people who in any way have been E-PP0435
affected by the armed conflict: veterans, their families, internally Detecting depression on social media
displaced people etc. The counsellors are professional psychologists
for supporting patients’ management
who were trained within the scope of the project. Sessions may be
A. Leis1* , F. Ronzanco1 , M.A. Mayer1 , C. Castillo2 , M. Torrens3 , L.I.
held in Russian or Ukrainian, according to the user’s choice.
Furlong1 , F. Sanz1
Results.– The key and most frequent issues mentioned by the clients 1 Research Programme on Biomedical Informatics GRIB, Hospital del
are loneliness, the loss of the sense of life, fear, uncertainty, anx-
Mar Medical Research Institute IMIM, Department of Experimental
iety, difficulties in family relations, in particular, with children,
and Health Sciences, Universitat Pompeu Fabra UPF, Barcelona,
job insecurity, addictions, psychosomatic disorders and so oth-
Spain; 2 Institute of Neuropsychiatry and Addictions, Hospital del
ers. Essentially, information on the opportunity to get psychosocial
Mar Medical Research Institute IMIM, Barcelona, Spain; 3 Institute of
online care is communicated via social media; therefore, to pre-
Neuropsychiatry and Addictions, Hospital del Mar Medical Research
vent no-show cases, a step-by-step procedure with the description
Institute IMIM, Psychiatric Department of Universitat Autonoma de
of registration and counselling was made, which enabled to gradu-
Barcelona, Barcelona, Spain
ally reduce the number of addresses without actual online sessions * Corresponding author.
with a counsellor from 81.8% in October, 66.7% in November, 50%
in December 2017 to 20.8% in January 2018. Background and aims.– Over 300 million people are suffering from
Conclusions.– Most frequent issues mentioned by the IDPs are depression worldwide, with an important impact in health care sys-
loneliness, the loss of the sense of life, fear, uncertainty, anxiety, tems and, in some cases, leading to suicide ideation and attempts.
difficulties in family relations, in particular, with children, job inse- People with depression also use social media (SM) platforms to
curity, addictions, psychosomatic disorders. share information and experiences about their illness.
Disclosure of interest.– The authors have not supplied a conflict of To identify the behavioral patterns of Twitter users and the lin-
interest statement. guistic features of tweets in Spanish that could suggest signs of
depression.
Methods.– Using the Twitter API for streaming tweets, we selected
E-PP0434 a set of tweets of users who publicly mentioned in their profile
Stopblues: a French e-health device to that they suffer from depression (n = 1,100), and tweets selected
prevent suicide in the general randomly (n = 1,006,000). Linguistic features obtained with Natural
population Language Processing tools were compared between the two sets of
A. Le Jeannic* , M.A. Vinet, K. Chevreul tweets.
Assistance Publique, Hôpitaux de Paris/INSERM, URC Eco/UMR 1123, Results.– The use of the first-person singular pronoun from depres-
Paris, France sive users doubles those of general users. The main emotion
* Corresponding author. expressed in the depression dataset was sadness (34,5%) mean-
while happiness (54%) was in the random sample (p < 0.01). In the
Background and aims.– France is one of the Western European depression sample the number of negation words compared to the
countries most affected by suicide, an epidemiological burden asso- random sample was 56% versus 78% without negation words, and
ciated with a high societal cost of several million euros per year. 28% versus 16% for one word respectively (p < 0.01). The depressed
Several European projects have either implemented web-based users tended to send more tweets during the night.
interventions for care of mental disorders associated with suicide Conclusions.– Social media have been proposed as a tool for mon-
or recommended online actions which have demonstrated their itoring different diseases such as depression. The language and
effectiveness for suicide prevention. features of the tweets of depressive users show significant different
The objective of the project was the construction of an application from non-depressive ones. Linking social media to electronic health
and website to prevent suicide in the general population, with its record could help health professionals in follow-up and decision-
promotion being supported by local authorities and general prac- making of depressed patients.
titioners (GPs). Disclosure of interest.– The authors have not supplied a conflict of
Methods.– The detailed content of the devices and promotional interest statement.
tools to be made available to local authorities and GPs was deter-
mined through literature reviews and focus groups with experts
(psychiatrists, local authorities’ workers) and potential users. E-PP0436
Results.– An application and a website were constructed with two Technolgy and psychiatry: negative
parts: a public interface with videos about psychological suffering, aspests of a flourishing relationship
coping strategies and the help available, and a private interface P. Malliaris
which requires registration and gives access to a map with local General Hospital of Karditsa, Psychiatry, Karditsa, Greece
resources and contact information (psychiatrists, psychologists, * Corresponding author.
associations. . .), mental health questionnaires, a safety plan to fill
in case of crisis, an emergency button, and many tips and videos to Background and aims.– The incorporation of new technological
overcome a period of psychological suffering (see Fig. 1). application in all medical fields is a universal phenomenon that
Conclusions.– StopBlues can be downloaded on iOs and Android also affects Psychiatry. The use of online or mobile psychometric
stores, and is available at www.stopblues.fr. Forty local authorities instruments, psychiatric smartphone applications, technologically
are involved in StopBlues promotion. advanced medication or new forms of psychotherapy, like distance
Disclosure of interest.– The authors have not supplied a conflict of therapy or virtually reality based therapy, are the new psychiatric
interest statement. trends. Nevertheless, this flourishing relationship also manifest
negative aspects, not well documented.
Methods.– In order to illuminate the negative consequences of tech-
nological aspects, in relation with clinical psychiatric practice, a
review of relevant research articles in Pubmed database has been
made, in addition to an attempt to categorize systematically alter-
native, technology-related presentations of psychiatric symptoms
in most areas of psychopathology.
Results.– Through the classification of alternative novel presen- E-PP0438

tations of psychopathological symptoms, especially prodromal or Does self-efficacy provide buffer
negative psychotic symptoms, mania-related behavior and suici-
against negative mental health
dality, their implications in the internet-context digital world of
social media are highlighted. Furthermore, technologically related
consequences of cyber victimization?
psychopathologies that have recently emerged, like on-line para- Implications for intervention
philias, the proposed in DSM 5 Internet Gaming Disorder, or cultural S. Musharraf1,2* , S. Bauman3 , M. Anis-ul-Haque1
1 National Institute of Psychology, Quaid-i-Azam University,
syndromes, like Hikikomori syndrome in Japan, are presented.
Conclusions.– Technology and especially internet, has already trans- Islamabad, Pakistan; 2 The department of Applied Psychology, The
formed the model of medical practice, since the easy access and Women University, Multan, Pakistan; 3 Disability and
abundance of the available, yet unconfirmed and unreliable infor- Psychoeducational Studies, The University of Arizona, Tuscon,
mation, has resulted in a transition from an ‘informed patient’ Arizona, USA
care to a ‘patient (mis-) informed’ care. Despite the undeniable
progress in disease prevention, objectification of diagnosis and
Background and aims.– Cyber victimization is a global public health
treatment options, technology does seem potentially dangerous
issue and the growing body of research on both adolescents and
or even harmful, under certain circumstances, concerning mental
young adults has confirmed its negative impacts on the mental
health issues, a fact that the psychiatric community should recog-
health of victims. This study investigated the role of self-efficacy
nize, highlight and further research.
as a potential factor to deal with the negative mental health conse-
quences of cyber victimization.
interest statement.
Methods.– The sample was composed of 1314 Pakistani univer-
sity students. Data were collected on cyber victimization, cognitive
E-PP0437 appraisals of the cyber victimization, general self-efficacy, ICT self-
efficacy, social desirability, traditional victimization, depression,
Artificial intelligence and intuition anxiety, and stress. Based on the assumptions of the study, a moder-
G. Hesles Sanchez1 , L. Moron Nozaleda2*
1 ated mediation model was developed to test the role of self-efficacy
Universidad Miguel de Cervantes. Universidad Villanueva, Social
on the effect of cyber victimization on depression, anxiety, and
Science, Madrid, Spain; 2 Pofessor Dr, Neuroscience, Madrid, Spain
* Corresponding author. stress through four types of appraisals: challenge, threat, centrality,
and resources.
Background and aims.– Fuzzy or fuzzy logic, approximate reasoning, Results.– Controlling for the effect of age, gender, traditional victim-
there are many advances by experts in artificial intelligence (AI) to ization, ICT self-efficacy and social desirability results showed that
simulate natural intelligence with algorithms. cyber victimization resulted in negative appraisals (threat, and cen-
But how to translate intuition, imagination, ambition for knowl- trality) and self-efficacy increased positive appraisals (challenge
edge or even human obsessions, perceptible from the earliest ages, and resources). Furthermore, self-efficacy moderated the effect
to mathematical algorithms? In a materialized, algorithmized sci- of cyber victimization on all four types of appraisal. Self-efficacy
ence, there is no place for concepts such as intuition or, let us say, decreased negative mental health consequences by increasing the
the feeling that they are, to a large extent, responsible for achieving effect of positive appraisals and decreasing the effect of negative
the advances that are marking the first third of the 21st century. appraisals. The model explained 15% variance in depression, 19.4%
Methods.– General research. Specialized journals, web sites and in anxiety, and 22% in stress and showed a good fit to the data.
books. Conclusions.– It is concluded that general self-efficacy is an impor-
Results.– Intelligence is a construct, it is not a formula. Its definition tant positive factor that should be focused on while planning and
is in constant review and scientists have not managed to reach an implementing interventions to counter the effect of cyber victim-
agreement in centuries. How is an “artificial” production system ization on mental health.
designed and elaborated correctly from a construct that lacks def- Disclosure of interest.– The authors have not supplied a conflict of
inition?The simulation of human intelligence based on algorithms interest statement.
exponentially multiplies capacities, but also, in the case of failed
or malicious algorithms, errors. Unknown, latent or immediately
E-PP0439
explosive errors, already processed, converted into big “misdata”.
Conclusions.– It is necessary to develop a theory about ethics and Suicide in Bangladesh reported in
even the philosophy applied to AI, and, therefore, the urgent imbri- facebook
cation of the humanities in a world that we are entering fully, that T. Rashid Soron
of AI, when not even, until now we have been able to define the Telepsychiatry Research and Innovation Network, Telepsychiatry
concept of intelligence. Innovation Lab, Khulna, Bangladesh
interest statement.
Background and aims.– Globally data quality of suicide is poor, and
the problem is more prominent in developing Countries where
suicide stigmatized. In Bangladesh, suicide is stigmatized and con-
sidered as a criminal offense that makes the data quality worse.
With the rise of the popularity of Facebook, it becomes an impor-
tant source of information data for suicide. In this study, we aimed
to find out the different pattern of reported suicide in various public
sources in Facebook.
Methods.– This cross- sectional study was conducted from January
2018 to June 2018. Three independent data collectors collected
information on suicide from the different public Facebook pages
and profiles. One research associate rechecked their reported data
and after cross checking he entered the information in the SPSS-
24.
Results.– Six eighty-nine cases were reported to commit suicide Background and aims.– According to the World Health Organiza-
during this study period. Their age ranged from 8 to 86 year and tion (WHO) report 2001, around 450 million people suffer from
female committed more suicide. About 67% of people committed mental health disorders globally. Despite the high prevalence and
suicide by hanging, followed by poisoning, jumping, cut injury etc. potentially disabling consequences of mental disorders, specialized
Thirty-nine different reasons were reported as the related cause of mental health services are extremely deficient. Over 70% of this
suicide. population does not have access to mental healthcare. These facts
Conclusions.– This study provided an overview of different pat- clearly manifest an urgent need of looking into other methods of
tern of suicide in Bangladesh. We observed few unique methods treatment and tele-medicine can help to overcome geographical
of suicide that were not previously reported. Moreover, the study barriers, and increase access to health care services.
revealed different unnoticed causes of suicide. The government of Methods.– This is a cross sectional study on 382 patients seen at
Bangladesh is not ready to spend millions of dollars to monitor sui- Gilgit Medical Centre and Booni Medical Centre. Data was collected
cide. However, a real time national database is required to track from VirtualDoc after approval from ethical review committee,
and make necessary plan to prevent suicide. Facebook can be used this includes information on socio-demographic details, present-
a cost-effective source of data. ing complains, assessment and management. Data was entered and
Disclosure of interest.– The authors have not supplied a conflict of analyzed using SPSS version 19.0.
interest statement. Results.– There were more males than females. Most patients were
in the age range 21–30 years. The most common psychiatric diag-
nosis was depression and they were prescribed medications. All the
E-PP0440 patients seen were satisfied with the service provided
Digital epidemiology of paraphilias on Conclusions.– The greatest promise of tele-psychiatry is providing a
information exchange platforms feasible alternative for the existing and grossly scarce mental health
D. Sendler1* , M. Lew-Starowicz2 services. Tele-psychiatry facility has filled the gap in service deliv-
1 Felnett Health Research Foundation, Laboratory of Forensic ery and offered quality care in far and distant areas and has proved
Sexology, Legal Medicine- and Digital Ethnography, Staten Island, to be time saving, cost effective and resourceful.
USA; 2 Institute of Psychiatry and Neurology, III Department of Disclosure of interest.– The authors have not supplied a conflict of
Psychiatry, Warsaw, Poland interest statement.
Background and aims.– We present functional and clinically appli- E-PP0442

cable methodological pipeline for identifying, characterizing, and It takes four to tango! A study to
helping individuals affected by paraphilia, searching for help within explore the relationship between
Internet communities. To develop a research tool to examine how
compulsive buying, depressive
people with paraphilias use online technologies to network and
exchange health information symptomatology, coping strategies
Methods.– We applied mixed-methods approach, combining tools and personality traits
in qualitative content analysis of and survey research. D. Singh1* , V. kirpekar2 , A. faye2 , R. tadke3 , S. gawande4 , S. bhave4
1 BJ Govt Medical College and Sassoon Hospital, Pune, Dept of
Results.– Our data comes from an extensive digital ethnogra-
phy of 958 zoophiles, 245 pedophiles, and 320 sadomasochistic Psychiatry, Pune, India; 2 NKP Salve Medical College, Psychiatry,
fetishists. The proposed approach entails three steps of analy- Nagpur, India; 3 NKP Salve Medical College, Psychiatry, Nagpur,
sis — retrospective qualitative review of messages, quantitative India; 4 NKP Salve Medical Colg, Psychiatry, Nagpur, India
surveys, and semi-structured video interviews. The final step is
interventional — a long-term structured psychotherapy, offered
online. For zoophiles, we determined information related to sexual
Background.– In recent times with the global paradigm shift there
and co-habitation practices, pornography sharing, and prevalence
has been an exponential growth but paucity of research in the
of sadistic traits. For pedophiles, we identified modes of shar-
developing countries with respect to compulsive buying disorder.
ing pornography (i.e. using unregistered servers) without getting
Aims: This study aims to assess the prevalence of compulsive buy-
caught by police. For gay-sadomasochists group, we identified
ing disorder and its relationship with depressive symptomatology,
important themes explaining safe sex practices, functional role of
coping strategies and personality traits.
having a verbal consent, and safe words, as means of preventing
Methods.– After ethics committee approval 286 MBBS students,
long-term sexual trauma. In all three studies, participants self-
interns and post graduate residents were included in the study. Self-
reported distress, imposed by their unusual sexuality. Given that
self-admission, we reasoned that there is need to develop online reported semi-structured questionnaire which included details
about socio-demographic profile, Richmond Compulsive Buying
counseling for paraphilias.
Scale, Patient Health Questionnaire 9, Coping Inventory for Stress-
Conclusions.– Our work offers specialized approach to conducting
ful Situation 21 (CISS-21) and Mini-International Personality Item
digital ethnography, with intention to offer follow- up counseling
Pool were administered after written informed consent. Data was
provided online to those needing it.
then analyzed statistically.
interest statement. Results.– Compulsive buying disorder was seen in 23.77% of the par-
ticipants with significantly more prevalence in younger age group
and in females. Compulsive buyers had significant trouble related
E-PP0441 to finances and relationships [83.82%] and most used shopping
to increase their self esteem [72.05%]. Depressive symptomatol-
Tele-psychiatry in Pakistan -
ogy was seen in 63.23% patients. Compulsive buyers used more
experience at AGA Khan University of avoidance and emotion based coping than task oriented cop-
Hospital (AKUH), Karachi ing mechanisms. Severity of compulsive buying was negatively
S.A. Siddiqui correlated with task based coping and positively correlated with
Aga Khan Univeristy, Psychiatry, Karachi, Pakistan avoidance and emotion based coping. Higher score on neuroticism
& extraversion and a low score on conscientiousness was seen in
compulsive buyers.
Conclusions.– This study is one of the very few studies in the Aim: To understand if depression can represent a risk factor for
developing country like India. Further research will help us in deter- cancer incidence, progression and survival.
mining the causal relations as well as management interventions. Methods.– A survey was made on depression as a risk factor
®
Disclosure of interest.– The authors have not supplied a conflict of for cancer; PubMed and ClinicalKey databases were searched
interest statement. to identify studies and meta-analysis on the subject. The key
words/expressions: “depression”, “risk factor” and “cancer” were
used.
E-PP0443 Results.– 24.6% of cancer patients suffered from at least one cate-
Epidermoid CYST of cerebellopontine gory of syndromal depression (major depression, minor depression,
angle with cerebellar tonsillar descent or dysthymic disorder). Chronic depression was associated with
revealed by depressive and anxiety a higher risk for cancer incidence. Depression is associated with
more rapid progression, increased symptons of cancer (especially
symptoms: a case report pain), shortened survival [2] and with treatment non-adherence.
S. Tlili1 , A. Rebai2 , M.W. Krir3 , R. Maamouri4* , C. Ben Cheikh3 , A.
Psychophysiological mechanisms linking depression and cancer
Baatout3 , H. Kefi3 , A. Oumaya3
1 Medical School of Tunis, Family Medecine, Tunis, Tunisia; 2 Medical progression include dysregulation of the hypothalamic-pituitary-
adrenal axis, especially diurnal variation in cortisol and melatonin
School of Tunis, Psychiatry, Tunis, Tunisia; 3 Military Hospital of
[3].
Tunis, Psychiatry, Tunis, Tunisia; 4 Medical School of Tunis,
Conclusions.– Depression affects the immune function, affecting
Psychiatry, Psychiatry, Tunisia
* Corresponding author. cancer incidence and progression; it also complicates the way
patients cope with cancer and the adherence to treatment.
Background and aims.– Tumors of the cerebellopontine angle (CPA) There is a growing evidence of a mutual relationship between can-
represent 5%–10% of all cranial tumors. Psychiatric features associ- cer and depression; this is of uttermost importance on finding
ated with CPA tumors are uncommon and not specific leading to a new opportunities for therapeutic intervention. Further research
delayed diagnosis. is necessary to determine whether optimal depression treatment
Methods.– We will discuss a clinical case and we will procede to a improves cancer survival.
bibliographic research about the case. Disclosure of interest.– The authors have not supplied a conflict of
Results.– A 44 years old man with no medical history consulted interest statement.
for insomnia. The patient had several stress factors (family and
professional conflicts). The first interview revealed many symp-
toms especially diminished ability to concentrate, sad mood, loss E-PP0445
of interest, anxiety and irritability. The clinical examination did not Quality of life in patients with breast
reveal any neurological signs. The diagnosis of Major depressive cancer in relation to oncological
episode has been made. A cerebral CT scan was performed show- characteristics of the disease
ing an extra-axial expansive process of the right cerebellopontine J. Stojanov* , O. Zikic, A. Cvetanovic, I. Binic, J. Antonijevic
angle compatible with an epidermoid cyst. A cerebral MRI was com- Faculty of Medicine, University of Nis, Department of Psychiatry, Nis,
pleted which showed that the tumour has a mass effect on the Serbia
brainstem. There was also a ptosis of the cerebellar tonsils in the * Corresponding author.
occipital foramen suggesting Arnold- Chiari malformation type I.
Neurosurgeons did not indicate surgical treatment but regular radi- Background and aims.– Breast cancer is the most common cancer
ological monitoring. Meanwhile the patient received sertraline as among women worldwide. It is, therefore, important to consider
an antidepressant and the course was marked by a partial remission every woman individually with breast cancer and assess their qual-
of symptoms. ity of life (QOL). QOL provides a meaningful way to determine the
Conclusions.– The pathological mechanisms of depressive and anx- impact of health care and it is an integral part of cancer patient man-
ious symptoms caused by a tumor of the cerebellopontine angle agement. Objective was to evaluate correlation of different domains
are multiple. Hydrocephalus, ptosis of the cerebellar tonsils, com- of quality of life and oncological characteristics in women who are
pression of the brainstem inculding serotonergic systems in the diagnosed with breast cancer.
dorsal and median raphe nucleus and compression of the internal Methods.– The study involved 95 patients with breast cancer who
temporal region are the hypotheses found in the litterature. completed surgical treatment and are currently receiving adjuvant
Disclosure of interest.– The authors have not supplied a conflict of therapy. It was taken into account the type of cancer and their hor-
interest statement. monal sensitivity, as well as the duration of the disease. Information
on tumor characteristics and treatment was abstacted from medi-
cal records. Patient’s quality of life was assessed using the 15-item
E-PP0444 Flanagan’s Quality of Life Scale (QOLS), modified by adding a 16th
Depression as a risk factor for cancer item on independence.
C. Pereira* , I. Caldas, I. Pinto Results.– The results have shown a correlation between poor quality
Centro Hospitalar Psiquiátrico de Lisboa, General Psychiatry, Lisbon, of life and the duration of the illness (p = 0,017). Quality of life is
Portugal considerably depending on whether the cancer is hormon-sensitive
* Corresponding author. (p = 0,004) or not as well is the cancer HER positive or negative
(p = 0,034).
Background and aims.– Conclusions.– The quality of life in patients with breast cancer is
Background.– Depression and cancer are common co-morbidities one of the most important outcome indicators for chronic diseases
[1]. Depression is now conceptualized as a systemic disease of associated with the oncological characteristics and the duration of
chronic inflammation; it has a well-known deleterious impact on the disease. Quality of life instruments can be useful in the early
the course and outcome of inflammatory-mediated medical ill- identification of patients whose score low on functional scales and
nesses [2]. There are evidences that depression predicts cancer symptoms.
progression and mortality and that providing psychosocial support Disclosure of interest.– The authors have not supplied a conflict of
reduces depression, anxiety, and pain, and may increase survival interest statement.
time with cancer [3].
E-PP0446 so categorized by Qualitative Content Analysis. The results were

Development of positive and negative peer-reviewed in the Laboratory of Clinical-Qualitative Research.
emotional reactions and level of Results.– The analysis resulted six emerging categories: (1) hard
experience in the process of getting ill, medical investigation and
anxiety in women treated for breast final diagnosis; (2) treatment paradoxes and the consolidation of a
cancer–initial reports psychosocial identity due to the HNC; (3) perceptions of a personal
A. Skiba, P. Maruszewska, J. Milczarek, M. Łukasik, B. Helman, M. impact from the RT; (4) elaboration of changes in body image and
Talarowska* relative social identity; (5) a post-treatment imagined/idealized
Medical University of Lodz, Department of Adult Psychiatry, Łódź, life; (6) the peculiarities of patient-health professional communi-
Poland cation.
Conclusions.– The ruptures in social life and emotional impact of
illness and treatment come accompanied by feelings of guilt and
Background and aims.– Cancer is the second most common cause
shame, as wells as a stigma experienced in the face of bodily
of death in the world. The most frequently diagnosed malignant
changes brought about by disease and RT. Negative impact on self-
disease among women is breast cancer (about 25% incidence) with
image, limitations in social life, thoughts of death, and grief were
more than 2 million new cases in 2018. The diagnosis and treat-
related to treatment.
ment of breast cancer in many patients causes serious emotional
disorders such as anxiety and depression.
interest statement.
The aim of the study was to measure the intensity of positive and
negative emotions and anxiety as a conditioned situational state
and personality trait in the studied group.
Methods.– Twenty-three patients with diagnosed breast cancer E-Poster Presentation: Eating Disorders - Part I
took part in the study. The Polish adaptation of the Positive and
Negative Affect Schedule (PANAS) by D. Watson and L.A. Clark as
well as the Polish adaptation of The State-Trait Anxiety Inventory
E-PP0448
(STAI) by C. D. Spielberger, R. L. Gorsuch, R. E. Lushene were used
to assess emotions as a state and as a trait. Gender-related patterns of emotion
Results.– Statistical analyses show that in the studied group: regulation among patients with
- the \taverage of positive emotions as a state (28.92) is lower than eating disorders
the \taverage of positive emotions as a trait (34.67); Z. Agüera1* , G. Paslakis2 , L. Munguía3 , I. Sanchez2 , R. Granero4 , J.
- the average of negative emotions as a state (21.67) is higher than Sánchez-González2 , S. Jiménez-Murcia1 , F. Fernández-Aranda1
the average of negative emotions as a trait (18.17); 1 University Hospital of Bellvitge-IDIBELL/CIBERobn/University of
- the \taverage level of anxiety as a state (41.42) is higher than the Barcelona, Psychiatry, Barcelona, Spain; 2 University Hospital of
level \tof anxiety as a trait (38.34). Bellvitge-IDIBELL, Psychiatry, Barcelona, Spain; 3 School of Medicine
Conclusions.– Psychological decompensation, which manifests and Health Sciences, University of Barcelona, Department of Clinical
itself in an increased sense of anxiety and increased experience of Sciences, Barcelona, Spain; 4 Autonomous University of
negative emotions with simultaneous reduction of positive emo- Barcelona/CIBERobn, Department of Psychobiology and Methodology,
tions, occurs in the group of women treated for breast cancer. Barcelona, Spain
interest statement.
Background and aims.– Difficulties in Emotion Regulation (ER) are
common in females with eating disorders (ED). However, no study
E-PP0447 has so far analyzed ER in males with ED. Objectives: to assess ER
Emotional meanings attributed to the in males with ED and to compare results with both females with
ED and male and female healthy controls (HC). To examine asso-
head and neck cancer by Brazilian
ciations between ER difficulties and personality as well as other
University outpatient service during psychopathological features.
radiotherapy: a qualitative study Methods.– A total sample of 62 males with ED were compared
A.R. Malta1 , A. Weber1* , M.E.F. Bremberger1 , C.S.P. Lima2 , E.R. with 656 females with ED as well as 78 male and 286 female HC.
Turato1 Besides psychopathology and personality features, ER was assessed
1 University of Campinas, Laboratory of Clinical-Qualitative Research
by means of the Difficulties in Emotion Regulation Scale (DERS).
- LPCQ, Campinas, Brazil; 2 University of Campinas, Department of Results.– As expected, males and females with ED showed greater
Medical Clinic, Campinas, Brazil ER difficulties compared to HC. Also, females with ED displayed
statistically higher scores than males with ED in most DERS sub-
scales, albeit statistical effect sizes were small. Increased deficits
Background and aims.– Contextualizing, in Brazil the diagnosis of
in interoceptive awareness, pronounced general psychopathology
Head and Neck Cancer (HNC) usually occurs when the disease is
and lower self-directedness were shared factors associated with
already at an advanced stage. Biopsychosocial damages resulting
higher ER difficulties in both males and females with ED. However,
from illness and treatment of radiotherapy (RT) interfere meaning-
while higher novelty seeking, lower reward dependence and lower
fully in patients’ quality of life, but each psychosocial group has its
self-transcendence were related to higher ER difficulties in females
manner of reacting.
with ED, lower persistence as a personality trait was significantly
This work aimed to explore the emotional meanings attributed by
associated with ER difficulties in males with ED.
patients with HNC to both their disease/illness and the treatment
Conclusions.– Results suggest that males and females with ED show
during RT at the General Hospital at the University of Campinas,
similar ER difficulties, yet distinct in some aspects with regard to
South-eastern Brazil.
specific personality traits. Based on these results, greater emphasis
Methods.– A qualitative study using semi-directed interviews with
and future studies on strategies promoting ER in the treatment of
open-ended questions, in-depth. Thirteen invited patients have
males with ED are needed.
participated of the study in sample closed by saturation of infor-
mation. The interviews were audio recorded, fully transcribed and
interest statement.
E-PP0449 Results.– One third of the sample (34%) had high score of EAT-
“The golden cage”–revisiting hilde 26. Older age students, obese, secondary grade, wishing to wear
bruch revolutionary concepts on small clothes, and obsessed or preoccupied by watching a fashion
models news had higher EAT-26 score with statistically significant
anorexia nervosa differences p value (0.03, 0.05, 0.01, 0.001, 0.01) respectively. In
B. Almeida* , C. Machado, C. Fonseca, C. Fragoeiro, L. Monteiro
1 Hospital Magalhães Lemos, General Adult Psychiatry, Porto,
relating eating disorder with eating behavior, it was significant
with use laxative, diuretics to control weight 7% (P = 0.04) and 18.8%
Portugal
(P = 0.01) with thought for attempt suicide. About 69.6% of the sam-
pled female students had high score of OCI-R. The association rate
Background and aims.– Anorexia nervosa (AN) is the oldest recog- between OCD and EDs was 40.2% (P = 0.002).
nized eating disorder, but its aetiology is still poorly understood. Conclusions.– The prevalence of having OCD was very high. Also, one
With this work, the authors review the theoretical model of AN pro- out of each three girls recorded some degree of eating disorders.
posed by Hilde Bruch, one of the most influential figures in eating We found a very high association between having OCD and EDs,
disorders field. and significant association with suicidal thought or attempt.
Methods.– A literature review on eating disorders textbooks and Disclosure of interest.– The authors have not supplied a conflict of
PubMed database was performed, using the terms “anorexia ner- interest statement.
vosa” and “Bruch.”We selected the chapters and articles written in
English, which fulfilled the objectives exposed above.
E-PP0451
Results.– Bruch conceptualized AN as manifestation of an
underlying self-disorder–self-starvation represents a struggle for The REVAM project: a virtual reality
autonomy and self-esteem. With the ideal of “mind over body” based clinical tool to correct body map
patients experience for the first time they have power and control. overestimation in anorexia nervosa
Anorexics’ families communicate with a “confusion of pronouns”, P. Barbara1* , D. Clus1 , M. Walter1 , N. Le Bigot2 , S. Berrouiguet1
without expression of negative feelings. Patients feel obligated to 1 University Hospital of Brest, Psychiatry, Brest, France; 2 Université
fulfil the expectations of others, fearing they aren’t good enough. de Bretagne Occidentale, Psychologie, Brest, France
Also, the relationship with parents is too close, without separation, * Corresponding author.
individuation, and differentiation. AN occurs as a developmental
crisis, when the adolescent is faced with the task of becom- Background and aims.– Patients suffuring from Anormexia Nervosa
ing increasingly independent. Additionally, Bruch defends that (AN) disclaim their body despite effective pathological thinness.
patients didn’t develop accurate interpretations of their own per- Such a mismatch appears to be underpinned by a cognitive bias
ceptions and can’t differentiate between disturbances in their leading to body map overestimation. Individuals look like block
biological field, emotions and interpersonal experiences. The goal into a null and void body map.
of therapy should be to help patients develop a valid self-concept The aim of this study was to test both acceptability and efficiency
and autonomy–like a sparrow in a golden cage to whom treatment of an virtual reality based dispositif which lead AN users to correct
help to discard the notions and ideas that built the cage. their body map by embodying an avatar.
Conclusions.– Bruch established a new model for AN understand- Methods.– REVAM is a monocenter controlled trial conducted by the
ings, conceptualisations and treatment, based on developmental Brest Univesity Hospital, France. Two groups, healthy (n = 28) and
disturbances and family interactions, still valid today. AN (n = 10), participants were asked to estimate their possibility to
Disclosure of interest.– The authors have not supplied a conflict of pass through different doors in order to mesure their perceptive
interest statement. body map threshold after five conditions of expositions to their
chosen avatar: a baseline modality, a neutral modality, a morphing
modality, a visuo-tactile stimulation and crossed modality (morph-
E-PP0450 ing*stimulation). After immersive session, participants were asked
Prevalence of eating disorders and to answer acceptability and tolerance questionnaires.
Results.– Results suggested that the REVAM dispositive is well
obsessive-compulsive disorder among
accepted and tolerated. Moreover a visuo-tactile stimulation leads
adolescents schoolgirls: sample from participants to a better passibility than before the avatar exposure,
Abha City Southern Saudi Arabia expressing a more accurate perceptive body map threshold by the
S. Alsubaie1* , B. Alalfard2 , A. Muhaya2 , H. Albishi3 , H. Alalfard3 , K. AN group.
Abdullah Mohammad3 Conclusions.– This finding indicates that REVAM immersive clini-
1 Armed Forces Hospital, Southern Region, Psychiatry, Khamis
cal tool is accepted and tolerated by a AN population. Second, we
Mushayt, Saudi Arabia; 2 Khamis Mushayt Maternity and Pediatric proved that Full Body Illusion is efficient to supplant the correction
Hospital, Pediatrics, Khamis Mushayt, Saudi Arabia; 3 King Khalid of body map actualization, dysfunfctionning in AN.
University, College of Medicine, Abha, Saudi Arabia Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
Background and aims.– Adolescents concern about their body-
weight and shape can lead to disturbed eating behaviors. The main E-PP0452
aims of the current study are to estimate prevalence of both eat-
ing disorders EDs and obsessive compulsive disorders OCD among
Experimental treatment of
adolescent females, to explore if there is any association in between self-assertion curtails eating disorders
these disorders, and to correlate the results with different factors. (ED) symptoms
Methods.– We conducted a descriptive cross-sectional study among A.L. Barrios-Hernandez1* , A. Blanco Fernandez1 , M. Graell-Berna2 ,
224 girl students at six schools in Abha, southern Saudi Arabia. G. Gonzalez-Cuevas1
1 European University of Madrid, Psychology, Madrid, Spain; 2
The main tool of the study was a self-administered question-
naire including socio-demographic, behavioral questions, other Hospital Infantil Universitario Niño Jesus, Servicio de Psiquiatria y
important associated factors, Eating Attitude Test 26 (EAT-26) and Psicologia, Madrid, Spain
Obsessive-Compulsive Inventory–Revised short form (OCI-R).
Background and aims.– A deficit in assertive communication skills is Results.– Results. Supplementation with AKBA promotes moderate
a common hallmark in patients with Eating Disorders (ED) as well beneficial effects with low/rare adverse responses in physical ill-
as detrimental to their recovery. Overall, patients with the most nesses such as cancer, diabetes and osteoarthritis. AKBA may also
severe EA symptoms may have the most difficulty being assertive. be beneficial to reduce leukotrienes that are elevated in those with
Given that low assertiveness has previously been linked to exac- restrictive AN.
erbation of symptoms and worsening outcomes in these patients, Conclusions.– AKBA could be a novel, safe, cost-effective adjunct to
our aim was to study to what extent experimental manipulation of treatment, to increase weight gain, improve neurocognitive func-
parental self-assertion may impact EA symptoms. tion, psychiatric comorbidities and high relapse rates in AN
Methods.– Our sample comprised 79 female adolescents with ED Disclosure of interest.– The authors have not supplied a conflict of
that received group therapy treatment at Niño Jesús hospital in interest statement.
Madrid. Out of the 123 parents participating in the study, 59
were part of the experimental group and subjected to training in
assertive skills (8-week sessions for about 2 hours). In addition, 64 E-PP0454
parents formed the control group (with no assertiveness training). Anorexia nervosa and social
Before and after this training (or the same amount of time for the ostracism: a case-control study
control group), both parents and adolescents were administered P. Meneguzzo, E. Collantoni, P. Busetto* , E. Tenconi, A. Favaro
the questionnaire Rathus Assertiveness Schedule (RAS). Adoles- University of Padova, Department of Neurosciences, Padova, Italy
cents were also administered the Eating Attitudes Test (EAT), a * Corresponding author.
measure of symptoms characteristic of ED.
Results.– The experimental treatment significantly increased RAS Background and aims.– In the present study, we aimed to compare
scores in both adolescents and parents in comparison with their the emotional and the cognitive response of patients with Anorexia
control groups. Furthermore, there was a significant decrease in Nervosa (AN) during a social ostracism experience and an inclusion
EAT symptoms in adolescent patients after their parental assertive- one.
ness intervention. No significant changes were observed, however, Methods.– We enrolled 20 AN patients and 20 healthy controls (HC)
in the control group. to a virtual ball-toss game where they were randomly assigned to
Conclusions.– Our experimental treatment may represent a promis- the interpersonal ostracism experience or to an inclusion one. Par-
ing therapeutic opportunity not only for boosting the levels of ticipants were manipulated and instructed of being part of a virtual
assertiveness in adolescents with EA and their parents but also trio with other two participants present in an another room, but
ameliorating EA symptoms. they actually did not exist. AN and HC were ask to complete a sur-
Disclosure of interest.– The authors have not supplied a conflict of vey before and after the toss-game to evaluate the effect of being
interest statement. ostracised or included into a group activity.
Results.– Patients with AN showed a significantly lower difference
in the ability to change positive emotions before and after the
E-PP0453 game when compared to HC only for inclusion scenario (AN vs HC
Neuroinflammatory markers as p = 0.035), no differences in the excluded one. Examining the two
hypothalamic, hippocampal and samples separately, we found no emotional or cognitive modifica-
tion in AN patients when they were included or excluded; unlike,
prefrontal cortex targets for
HCs have shown greater emotional modification in exclusion sce-
anti-inflammatory intervention in nario than in the inclusion one (p = 0.027).
restrictive anorexia nervosa Conclusions.– We hypothesize that patients with AN might be
S. Brooks1* , H. Schioth B2 unable to communicate or to perceive different type of social inter-
1 Liverpool John Moores Uni, Natural Sciences and Psychology, Liver, action. These results could also our knowledge about both social
United Kingdom; 2 Uppsala University, Neuroscience, Uppsala, perception and interaction in patients with AN, especially the way
Sweden of perceiving self-emotional state or the possibility to modify their
self-emotional state according to to external behaviour, showing
an important target of therapeutic intervention.
Background and aims.– Anorexia Nervosa (AN) is an often Disclosure of interest.– The authors have not supplied a conflict of
resistant-to-treatment eating disorder associated with neuroin- interest statement.
flammation. Nuclear factor kappa light chain enhancer of activated
B cells (NF-kB) underlies activation of pro-inflammatory cytokines.
Animal models show NFkB activation in hypothalamic pro- E-PP0455
opiomelanocortin (POMC) and neuropeptide Y (NPY) hippocampal
Disordered eating behaviour in
and prefrontal cortex neurons is present in AN, and that sup-
pression of NFkB promotes weight gain and reduces anxiety and Portuguese University students–two
depression. AN, like other pathological weight loss conditions decades later
is associated with elevated levels of NFkB and the leukotrienes A.T. Pereira1 , B. Maia1,2 , M.J. Soares1 , H. Moreira3 , C. Cabaços1* , C.
interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor Marques1 , A. Macedo1,4
1 Institute of Psychological Medicine, Faculty of Medicine, University
alpha (TNF-al;), with sustained weight gain linked to normalisation
of these levels. Transcription regulation of IL-1, IL-6 and TNF-␣; is of Coimbra, Portugal, Institute of Psychological Medicine, Coimbra,
associated with the arachidonic 5-lipoxygenase (5-LOX) enzyme Portugal; 2 The Catholic University of Portugal, Faculty of Philosophy
within the NFkB pathway. and Social Sciences, Braga, Portugal; 3 University of Coimbra, Center
Against this background, we review inhibition of 5-LOX and for Research in Neuropsychology and Cognitive-Behavioral
leukotrienes with low-adversity acetyl-11-keto-beta-boswellic Intervention, Coimbra, Portugal; 4 Coimbra Hospital and University
acid (AKBA), a natural anti-inflammatory triterpenoid derived from Centre, Psychiatry Department, Coimbra, Portugal
the nutritional supplement Boswellia serrata.
Methods.– To investigate, studies of inflammatory markers in AN
Background and aims.– According to recent European community-
and weight loss populations (n = 28) and Boswellia Serrata/AKBA
based studies, rates of anorexia and bulimia nervosa remained
(n = 103) are reviewed in light of potential weight gain and psychi-
stable or decreased since the 1990s (Smink et al., 2016). This may
atric effects of suppression of the 5-LOX NFkB pathway.
be due to improved detection and/or changes in diagnostic criteria.
However, other eating disorders and some specific disordered eat- more frequent than the consumption of a single sutance in our
ing/DE symptoms may be increasing (Keski-Rahkonen & Mustelin sample.
2016). Disclosure of interest.– The authors have not supplied a conflict of
Aim.– To analyse whether the levels of DE symptoms in univer- interest statement.
sity students have decreased or increased in comparison with the
beginning of the 2000’s.
Methods.– Sample 1: collected in 2000–2001; n = 500 (68.4% girls). E-PP0457
Sample 2: collected in 2017–2018; n = 455 (79.3% girls). Mean Cortical thickness and gyrification
age and BMI (20.14 ± 1.135 vs. 20.20 ± 1.1794; 21.52 ± 2.400 vs. index in eating disorders
21.41 ± 2.897) was not significant different between samples. G. Cascino1* , A. Canna2 , F. Esposito2 , A. Prinster3 , A.G. Russo4 , A.M.
Both samples answered the Eating Attitudes Test-25 (EAT-25; Monteleone1 , F. Di Salle2 , P. Monteleone2
Pereira et al., 2008; Marques et al., 2017), which evaluates Bulimic 1 University of Campania “Luigi Vanvitelli”, Department of
behaviours/BB and Diet. Psychiatry, Naples, Italy; 2 University of Salerno, Department of
Results.– In boys, total (3.76 ± 3.447 vs. 6.33 ± 5.842) and Diet Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, Section
(2.02 ± 2.015 vs. 3.73 ± 3.410) scores were significantly higher of Neuroscience, Salerno, Italy; 3 IRCCS SDN Istituto di Ricerca,
in sample 2. In girls, BB (3.32 ± 3.274 vs. 2.30 ± 3.247) was Department of Radiology and Nuclear Medicine, Naples, Italy; 4
significantly lower and Diet (2.42 ± 2.255 vs. 3.55 ± 3.059) was University of Salerno, Dipartimento di Scienze Politiche, Sociali e
significantly higher in sample 2. In both genders, 10 items were sig- della Comunicazione, Salerno, Italy
nificantly higher in sample 2, except for item 25 “Have the impulse * Corresponding author.
to vomit after meals”. Relevant items such as “Am preoccupied with
a desire to be thinner” (10), “Take laxatives” (15) and “Engage in Background and aims.– Eating disorders (EDs) are psychiatric ill-
dieting behavior” (23) were significantly higher in sample 2 in both nesses with possible neurodevelopmental etiopathogenesis. Aim
genders. of this study was to estimate and compare regional cortical thick-
Conclusions.– DE is not decreasing in Portuguese university stu- ness (CT) and gyrification index (GI), specific markers of deviations
dents. Given its serious health consequences we should consider from normal neurodevelopment, in females with EDs and healthy
to screen for ED in young adults. controls.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Twenty-two acute anorexia nervosa (acuAN), 10 recov-
interest statement. ered anorexia nervosa (recAN), 24 bulimia nervosa (BN) women
and 35 healthy controls (HC) underwent a 3T MRI scan. Data were
processed by FreeSurfer.
E-PP0456 Results.– Significant differences were found in CT of left and right
Eating disorders and substance use: lateral orbitofrontal cortex (OFC) and right medial OFC between
update and description of a sample of acuAN and recAN groups. AcuAN group showed reduced CT val-
ues in left inferior temporal regions compared to HC. Significant
patients in the eating disorders
positive correlations were found between body mass index (BMI)
treatment unity of Salamanca and CT in left and right lateral OFC and right medial OFC. AcuAN
N.M. Casado Espada* , J.I. De La Iglesia Larrad, S.R. Gamonal group showed greater values of GI in cingulate cortex and in para-
Limcaoco, R. De Alarcón Gómez, M.T. Lozano López, R. De La Mata central lobule, lower values in right parahyppocampal region than
Hidalgo, A. Macías Casas, D. González Parra recAN group and lower values of GI in left superior parietal cortex
Complejo Asistencial Universitario de Salamanca, Psychiatry, than HC. BN group showed lower GI in right frontal cortex com-
Salamanca, Spain pared to HC. BMI values correlated negatively with GI mean values
in parahyppocampal and paracentral clusters.
Conclusions.– Present results show CT and GI alterations in AN
Background and aims.– Comorbidity between eating and substance
patients and, for the first time, in BN ones. Although some of
use disorders can reach a 35% according to the different samples.
these changes seemed due to malnutrition, they may underlie psy-
The aim of this study is reviewing, collecting and presenting up-to-
chopathological aspects of EDs, since the altered areas are involved
date information on the usual association between addictions and
in modulation of brain functions such as body image perception,
eating disorders. Additionally, we analize comorbidity in a sample
which have a central role in ED psychopathology.
of patients attending out Unity for Treatment of Eating Disorders
in the Salamanca University Healthcare Complex
interest statement.
Methods.– Descriptive, restrospective observational study on a
sample of 281 patients diagnosed of Anorexia Nervosa, Bulimia Ner-
vosa and unspecified eating disorders. Diagnostic tests employed:
E-PP0458
EAT-40, EDI-2. In our clynical record model we included questions
about the use of substances. Literature review in the main search Social functioning in eating disorders:
engines. an evaluation of theory of mind,
Results.– 26% of the sample abused substances: 55% of the Bulimic empathy, self-other distinction and
patients, 35% unspecified eating disorder; 20% anorexia nervosa. pro-social behaviour (preliminary
The association of different substances was more frequent than the
findings)
use of only one substance. Alcohol and cannabis were the most
E. Corsi1* , E. Subhedar2 , J. Treasure1 , V. Ricca3 , V. Cardi2
prevalent. Comorbidity with Anxiety disorders (30%), Borderline 1 King’s College of London, Eating Disorders Department, London,
personality disorder (29%) and affective disorders (55%).
United Kingdom; 2 King’s College of London, Eating Disorder
Conclusions.– The prevalence of consumption in our sample is
Department, London, United Kingdom; 3 Azienda Ospedaliera
lower than expected according to the studies reviewed in the
Universitaria di Careggi, Psichiatria, Firenze, Italy
TCA population, however it is higher than the general population, * Corresponding author.
which supports the existence of similarities in the pathophysiol-
ogy between the two groups as well as an addictive model in the Background and aims.– It has been theorised that social difficulties
psychopathology of eating disorders, especially Bulimia nervosa play an important role in the maintenance of eating disorder symp-
(Bealy, Welch, Turón). Moreover, the polydrug use (2 or more) is toms. A lack of experimental research limits the conclusions that
can be drawn on the contribution of specific, modifiable psychoso- tive pathology, and greater emotional safety than patients with
cial factors on abnormal eating behaviours. This has implications AN.
for the development of personalised and targeted treatments. The publication was prepared with the support of the “RUDN Uni-
The goal of this project is to map the role that mentalization, theory versity Program 5–100”.
of mind, empathy, prosocial behaviour and self-other perceptual Disclosure of interest.– The authors have not supplied a conflict of
differentiation have in the maintenance of eating disorder symp- interest statement.
toms.
Methods.– Seventy-one women with an eating disorder and 30
healthy controls were recruited. Mentalization was assessed with E-PP0460
the Reflective Functioning Questionnaire (RFQ) and The Movie for The associations between disordered
the Assessment of Social Cognition (MASC). Empathy was measured eating attitudes, sociocultural
using the Empathy Accuracy Task and self-other distinction was
attitudes towards appearance,
evaluated with the Imitation-Inhibition task. Pro-social behaviour
was measured with The Prosocial Cyberball Game (PCG). comorbid psychiatric illnesses and
Results.– On average, the clinical group exhibited lower mental- self-esteem among Turkish women
ization skills (p < 0.001), greater difficulties in identifying fear and E. Deveci1* , B. Ince2
1 Isik University, Department of Psychology, Istanbul, Turkey; 2
anger (p = .072; p = 0.028) and in imitating others’ actions than
healthy controls (although not significantly). However, during the Istanbul Arel University, Department of Psychology, Istanbul, Turkey
prosocial game, the clinical group displayed a greater sensitivity to
social exclusion compared to the healthy group (p = .027). Difficul-
Background and aims.– Women are under pressure of ideal beauty
ties in SF and insecure attachment style were associated with the
standards shaped by all forms of media, family and friends. Liter-
severity of the eating disorder symptoms.
ature demonstrated that women who try to adapt themselves to
Conclusions.– These findings indicate that specific, modifiable, psy-
societal demands likely to have serious problems in eating atti-
chosocial factors are associated to the severity of eating disorder
tudes and behaviours. Thus, this study aimed to investigate the
symptoms and have the potential to inform the development of
relationships between disordered eating attitudes (DEA), sociocul-
targeted trainings to remediate these difficulties.
tural attitudes towards appearance (SATA), comorbid psychiatric
illnesses and self-esteem (SE) among Turkish women.
interest statement.
Methods.– 124 women aged between 19–46 years with body mass
index (BMI) ranged between 17.58–39.01 were recruited. Partici-
E-PP0459 pants were asked to complete questionnaires on SATA, DEA, SE and
demographic form.
Comorbidity of anorexia nervosa and
Results.– Descriptive analysis showed that 50% of the participants
bulimia with schizophrenia had Facebook account, 86% of them had Instagram account, and
I. Danilin1* , A. Arseniev2 , M. Artemieva1 , R. Suleymanov1 , A. 23% of them had Snapchat account. 52% of the participants were
Lazukova1 , Z. Niewozinska3 following body appearance related accounts. Findings of multiple
1 Peoples’ Friendship University of Russia RUDN University,
regression analysis showed that internalization of general attrac-
Department of Psychiatry and Medical Psychology, Moscow, Russia; 2 tiveness and muscular body and BMI statistically significantly
Medical and Psychological Center, “Mobilmed”, Dubna, Russia; 3 predicted DEA. Overweight and obese participants were found to
Pirogov Russian National Research Medical University, Moscow be significantly more influenced by the social pressure from family,
Scientific-and-Practical Center for Dermatovenereology and peers and significant others compared to those with low and nor-
Cosmetology, Moscow, Russia mal BMI. Moreover, low body fat and internalizing attractiveness
were positively related to DEA. Participants with a psychiatric ill-
ness had significantly lower SE and more DEA and internalization
Background and aims.– Objective: to study the role of schizophrenia
of SATA than participants without a psychiatric illness.
in the development of pathological food craving (PFC) and comor-
Conclusions.– Sociocultural attitudes and societal pressure can
bid impulse disorders in anorexia nervosa NA and bulimia nervosa
influence DEA which increases with the rise of BMI, existence of
BN.
psychiatric illnesses and low SE. Moreover, pressure from collec-
Methods.– A 15 years’ psychopathological follow-up study of 51
tivistic societies like Turkey might be more risky for internalization
patients with AN restricting type (16 patients, 31,4%) and BN (35
of ideal beauty standards.
patients, 68.6%) with comorbid schizophrenia.
Results.– The study revealed that the syndrome of pathological food
interest statement.
craving includes three main components: volitional, affective and
ideational. Prevalence of each component consequentially varied
depending on the duration of the eating disorder. On the early
E-PP0461
stages the affective component of PC was predominant. The maxi-
mum obsession and loss of situational control over food intake was Phenomenology of corporeality in
observed on the stage which can be characterized as loss of volition. anorexia nervosa
As a rule, it coincided with severe somatic-endocrine disturbances. O. Doerr
Stage of remission was characterized by impoverishment, deple- Universidad Diego Portales, Center for Studies on Phenomenology
tion of affect. and Psychiatry, Santiago, Chile
Conclusions.– Coenesto-hypochondriac, depersonalization disor-
Background and aims.– There are very few and only brief studies
der, in the form of stiffness, lethargy, increase muscle tone was
about phenomenology of corporeality in anorexia nervosa unlike
revealed in follow up of patients with AN. In patients with BN,
in other mental pathologies. On the base of a long experience with
there was a significant diversity, brutality of concomitant PC
anorexic patients, this author attempts to face this missing task.
accompanied by psychopathic behavior. These patients showed
Methods.– Applying the intuitive-phenomenological method, this
explosiveness, impulsiveness, exaggerated expression of emotions,
author describes how anorexic patients experience their body and
easy change of mood, lack of tact. Patients with BN had more chem-
compares it with the way the dysmorphophobic, depressive and
ical addictions (alcoholism, drug addiction, substance abuse) in the
schizophrenic patients do it.
catamnesis. Patients with BN showed high comorbidity with affec-
Results.– 1. There is an extreme splitting between the subject-body E-PP0463

(der Leib in German) and the object-body (der Körper in German). Binge eating disorder: are we
2. The anorexic treats her body as a fetish which can be modeled
speaking of food addiction?
at will. This goes beyond weight loss, since what she tries to do
T. Duarte* , I. Duarte Silva, B. Côrte-Real, G. Andrade, A. Neves
is to submit the body to her will of manufacturing design. 3. The
Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, E.P.E.,
anorexic exercises an absolute power over her body and its needs.
Serviço de Psiquiatria e Saúde Mental, Lisboa, Portugal
Thus, she does not respect hunger, or rest, or the appeal of sex. This * Corresponding author.
fascination for controlling everything appears also in the pleasure
experienced in realizing transgressor behaviors, as robbery. 4. The Background and aims.– Binge eating disorder (BED) is the most
anorexic feels repugnance for her body, for its flesh, for its volume. prevalent eating disorder and is characterized by chronic over-
Her aspiration goes much further than having the body of a model. consumption of food resulting in embarrassment and distress.
What she wants is being permanently losing weight, not having ‘Food addiction’ (FA) is currently not a recognized condition in
volume. 5. She lives her body as something obscene, as a degrading DSM-5. FA presents as a contentious construct and it is uncertain
show of her intimacy in the public space. if addictive eating behaviors are more closely related to substance
Conclusions.– All these characteristics lead the anorexic to a deep or gambling addiction.
feeling of abandonment and hopelessness. This way, her body and Non-systematic literature review on binge eating disorder and its
consequently, her world, have ceased being a dwelling. correlation with addictive disorders (AD).
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Pubmed database was searched between 2010 and 2018
interest statement. and articles with the the keywords “binge eating disorder”, “food
addiction”, “addictive disorder” and “substance use disorder” were
included.
E-PP0462 Results.– BED shares many characteristics with addictive behav-
Binge eating addiction among women iors (e.g., diminished control with significant urges to engage
who suffer from psychological abuse in binging episodes and continued use despite negative conse-
in their relationship: the moderating quences, resulting in distress/impairment). Neuroimaging studies
suggest corticostriatal circuitry alterations in BED similar to
role of defense mechanisms those observed in substance abuse: altered function of prefrontal,
O. Drori
insular, orbitofrontal cortices and the striatum. BED may be
Bar Ilan University, Socail work, Tel mond, Israel
related to maladaptation of the corticostriatal circuitry regulat-
Background and aims.– ing motivation and impulse control similar to that found in other
Objectives.– The participants will be able to recognize the pre- impulsive/compulsive disorders. Human genetics and animal stud-
dictors of Binge Eating addiction among women who suffer from ies suggest that there are changes in dopaminergic and opioidergic
psychological abuse in their relationships and will recognize the systems.
role of woman’s defense mechanisms in moderating the association Conclusions.– Overall, despite BED and AD represent unique con-
between psychological abuse and Binge Eating addiction. ditions, nascent research suggests an overlap between these
Methods.– A convenience sample of 380 Israeli women in rela- disorders. Future investigations need to take great care that AD cri-
tionships were located via the Internet, and after consenting, they teria are properly adapted to food and eating and that reasonable
completed a series of structured questionnaires. diagnostic thresholds are applied when diagnosing FA.
Results.– The higher the level of differentiation and mature defense Disclosure of interest.– The authors have not supplied a conflict of
mechanisms, the less addictive a woman is. However, the level interest statement.
of addiction among women who experience psychological abuse
with in their intimate relations, is higher than women who do
E-PP0464
not experience psychological abuse in their relationship. Among
women who experienced psychological abuse in their relations, A connectome analysis in anorexia
the defense mechanisms moderate the association between psy- nervosa by diffusion tensor imaging
chological abuse within intimate relations and the extent of the E. Collantoni1 , P. Meneguzzo1 , A. Girardi1* , A. Guaglianone1 , R.
addiction to binge eating. Manara2 , E. Tenconi1 , A. Favaro1
Conclusions.– The study raises awareness of therapeutic-related 1 University of Padova, Department of Neurosciences, Padova, Italy; 2
content that could strengthen women and help them to cope with University of Salerno, Department of Medicine, Surgery and
situations in their lives without the need to Binge. One of the Dentistry, Salerno, Italy
significant variables for therapeutic work is the level of differ- * Corresponding author.
entiation of the self. In addition, Identifying the types of defense

mechanisms and the environmental systems might help to match Background and aims.– In this study we used a connectomic
treatment to the woman’s emotional needs. Finally the study approach by means of Diffusion Tensor Imaging (DTI) tractogra-
leads to the recognition that Binge Eating, which is usually treated phy data to describe the rules that govern the interregional brain
with an emphasis on nutritional behavior change, is an addiction, interactions in Anorexia Nervosa (AN).
and as such, it requires a combination of mental, nutritional and Methods.– 38 patients with acute AN and 38 healthy controls (HC)
behavioral therapy. were included in this study. Freesurfer was used for the parcellation
Disclosure of interest.– The authors have not supplied a conflict of of the cortex, according to Destrieux atlas. FSL Probtrackx was used
interest statement. for the DTI tractograpy analysis. The Graph Analysis Toolbox was
used for the networks extraction.
Results.– From a global perspective, patients with AN showed a
reduced network clusterization and reduced small-world proper-
ties. From a regional analysis, patients with AN showed a higher
clustering coefficient in right anterior cingulate gyrus and a higher
betweenness in right fusiform gyrus. An analysis of the most cen-
tral and influential nodes in the network showed an identical hub
distribution in AN patients and HC, except for superior parietal lob-
ule and the right superior occipital gyrus. These two nodes showed
a high centrality and influence only in HC. Subcortical hubs were E-PP0466
equally represented in both groups. Psychiatric comorbidity as a risk
Conclusions.– From a global perspective, altered clusterization and
factor for the mortality of people with
small worldness indicate an unbalanced connectome wiring in AN.
Regional analysis evidenced local alterations in two areas with high
bulimia nervosa
integrative properties and with a role in AN pathophysiology, being H. Himmerich1,2* , M. Hotopf1,2 , H. Shetty2 , U. Schmidt1,2 , J.
involved in decision making processing and error detection and in Treasure1,2 , R.D. Hayes1 , R. Stewart1,2 , C.K. Chang1,2,3
1 King’s College London, Psychological Medicine, London, United
the recognition of face and body. Differences in hub distribution and
the absence of two important cortical hubs, allow to hypothesize a Kingdom; 2 South London and Maudsley NHS Foundation Trust, NIHR
weakness of the connective backbone architecture in AN. Maudsley Biomedical Research Centre, London, United Kingdom; 3
Disclosure of interest.– The authors have not supplied a conflict of University of Taipei, Department of Health and Welfare, Taipei City,
interest statement. Taiwan R.O.C.
Background and aims.– Bulimia nervosa (BN) is associated with

E-PP0465
increased mortality. Frequent comorbidities of BN include sub-
Psychiatric comorbidity as a risk stance use disorders, affective disorders and personality disorders
factor for mortality in people with (PD). These comorbidities may add an additional risk for mortality.
anorexia nervosa Methods.– We investigated the influence of these psychiatric
H. Himmerich1,2* , M. Hotopf1,2 , H. Shetty2 , U. Schmidt1,2 , J. comorbidities on all-cause mortality with demographic and socioe-
Treasure1,2 , R.D. Hayes1 , R. Stewart1,2 , C.K. Chang1,2,3 conomic factors considered as confounders over an observation
1 King’s College London, Psychological Medicine, London, United period from January 2007 to March 2016 for 1,501 people with
Kingdom; 2 South London and Maudsley NHS Foundation Trust, NIHR BN using anonymised health records data from the South London
Maudsley Biomedical Research Centre, London, United Kingdom; 3 and Maudsley NHS Foundation Trust (SLaM), retrieved through its
University of Taipei, Department of Health and Welfare, Taipei City, Clinical Records Interactive Search (CRIS) data resource. Mortality
Taiwan R.O.C. was ascertained through monthly linkages to the nationwide trac-
* Corresponding author. ing system administered by the Office for National Statistics (ONS).
We used Cox proportional hazards regression to calculate haz-
Background and aims.– Anorexia nervosa (AN) is found associated ard ratios (HRs) with 95% confidence intervals (CIs). Multivariable
with increased mortality. Frequent comorbidities of AN include analyses were also performed to estimate effects when controlling
substance use disorders (SUD), affective disorders (AD) and perfor confounding of age, sex, ethnicity, borough, marital status and
sonality disorders (PD). deprivation score.
Methods.– We investigated the influence of these psychiatric Results.– A total of 18 patients with BN died during the observation
comorbidities on all-cause mortality with demographic and socioe- period. The standardized mortality ratio (SMR) for our study cohort
conomic factors considered as confounders in the observation (against the population of England and Wales in 2012 as a standard)
window between January 2007 and March 2016 for 1,970 people was 2.52 (95% CI: 1.49–3.97). Cox regressions revealed significant
with AN, using data from the case register of the South London associations of mortality with older age and male gender. Comor-
and Maudsley (SLaM) NHS Foundation Trust, an almost monopoly bid PD (HR: 3.36; 95% CI: 1.05–10.73) was significantly associated
secondary mental healthcare service provider in southeast London. with all-cause mortality, even after controlling for demographic
We retrieved data from its Clinical Records Interactive Search (CRIS) and socioeconomic covariates.
system as data source. Mortality was ascertained through nation- Conclusions.– These results highlight increased mortality in patients
wide tracing by the UK Office for National Statistics (ONS) linked to with BN and the importance of recognising and treating PDs in
CRIS database on a monthly basis. patients with BN.
Results.– A total of 43 people with AN died during the obser- Disclosure of interest.– The authors have not supplied a conflict of
vation period. Standardized Mortality Ratio (SMR) with England interest statement.
and Wales population in 2012 as standard population for our
study cohort was 5.21 (95% CI: 3.77, 7.02). In univariate anal-
yses, the comorbidity of SUD or PD was found to significantly E-PP0467
increase the relative risks of mortality (HRs = 3.10, 95% CI: 1.21, Psychopharmacological advances in
7.92; and 2.58, 95% CI: 1.23, 5.40, respectively). After adjustment for
eating disorders
demographic and socioeconomic covariates as confounders, mod-
H. Himmerich1,2* , J. Treasure1,2
erately but not significantly elevated risks were identified for SUD 1 King’s College London, Psychological Medicine, London, United
(adjusted HR = 1.39, 95% CI: 0.53, 3.65) and PD (adjusted HR = 1.58,
Kingdom; 2 South London and Maudsley NHS Foundation Trust,
95% CI: 0.70, 3.56).
Bethlem Royal Hospital, London, United Kingdom
Conclusions.– These results suggest an elevated mortality in peo- * Corresponding author.
ple with AN, which might be, at least partially, explained by the
existence of the comorbidities SUD or PD. Background and aims.– Anorexia nervosa (AN), bulimia nervosa (BN)
Disclosure of interest.– The authors have not supplied a conflict of and binge eating disorder (BED) are the primary eating disorders
interest statement. (EDs). The only psychopharmacological treatment options for EDs
with approval in some countries include fluoxetine for BN and lis-
dexamfetamine for BED.
Methods.– We performed a literature search, a review of the clini-
cal charts of inpatients with AN treated with olanzapine, and two
quality improvement projects on a specialist unit for eating dis-
orders at the South London and Maudsley National Health Service
Foundation Trust to address the question how medication could be
beneficial for patients with EDs.
Results.– On the basis of the current literature, own data and theo-
retical considerations, possible drug targets for the treatment of EDs
may include signal molecules and receptors of the self-regulatory E-PP0469

system such as serotonin, norepinephrine and glutamate, the hedo- Bioelectric impedance as an effective
nic system including opioids, cannabinoids and dopamine and the
method of monitoring nutritional
hypothalamic homeostatic system including histamine, ghrelin,
leptin, insulin, and glucagon-like peptide-1.
status in patients with anorexia
Even though most patients with AN disagreed with the view that nervosa
medication would be able to reduce AN symptoms, more than half G. Kozak1* , M. Teter2 , J. Warchulińska2 , H. Karakula-Juchnowicz1 ,
of them said they would find medication useful if it helped reduce A. Makarewicz1 , T. Małecka-Massalska2
1 Medical University of Lublin, 1st Department of Psychiatry,
anxiety or sleep problems. Approximately 50% of inpatients were
administered “pro re nata” PRN medication during admission. Psychotherapy and Early Intervention, Lublin, Poland; 2 Medical
Conclusions.– On the one hand, there is a lack of psychopharmaco- University of Lublin, Department of Human Physiology, Lublin, Poland
logical studies and approved medications in EDs, on the other hand,
PRN medication is often prescribed - without any evidence in EDs
Background and aims.– Monitoring of nutritional status in a non-
- for pain, agitation, insomnia, digestive problems and anxiety.
invasive, reliable and accurate way is a vital aspect of caring for
anorexia nervosa patients (AN). One of objective techniques for
interest statement.
assessing a body composition is bioelectrical impedance analysis
(BIA).
The objective of the study was to compare nutritional status of
E-Poster Presentation: Eating Disorders - Part II anorexia nervosa patients (AN) and healthy individuals (HC) using
BIA method.
Methods.– We performed BIA in 51 AN patients (divided
into two groups depending on body mass index (BMI)
E-PP0468
(AN-1: n = 25; BMI = 15.18 ± 0.36 kg/m2 , and AN-2: n = 26;
Mesenteric superior artery syndrome BMI = 17.25 ± 0.24 kg/m2 ) and 20 healthy volunteers (HC:
and anorexia nervosa–a clinical BMI = 20.62 ± 1.17 kg/m2 ). BIA was used to assess the follow-
challenge ing parameters: 50 kHz phase angle (PA), membrane capacity
J. Jerónimo* , E. Reis, J. Rema, T. Cavaco, J. Santos (M.cap.), body cell mass (BCM), hydration index (H).
Centro Hospitalar Lisboa Norte, Serviço de Psiquiatria e Saúde Results.– PA was lower in AN-1 (4.36 ± 0.94) and higher in AN-2
Mental, Lisboa, Portugal (4.84 ± 0.62) compared to HC (5.71 ± 0.67). We found differences
* Corresponding author. in M.cap and BCM between the examined groups. The lowest
parameters were observed in AN-1 group and the highest in
Background and aims.– The superior mesenteric artery syndrome HC group (M.cap: AN-1 0.83 ± 0.19nF, AN-2 0.98 ± 0.21nF, HC
(SAMS) results from compression of the third portion of the duo- 1.40 ± 0.31nF, BCM: AN-1 14.42 ± 2.12 kg, AN-2 17.38 ± 2.10 kg, HC
denum, limited posteriorly by the aorta and anteriorly by the 21.63 ± 3.01 kg). Hydration was lower in HC (0.71 ± 0.04) compared
superior mesenteric artery. The simultaneous diagnosis of SAMS to both AN groups (0.80 ± 0.06 and 0.79 ± 0.07 for AN-1 and AN-2
and anorexia nervosa (AN) is rare, and there are only a few cases in respectively).
the literature. Conclusions.– Compared to healthy controls, PA, M.cap., BCM
Presentation of a clinical case illustrating the dilemma of the simul- were decreased in AN patients who, paradoxically, demonstrated
taneous diagnosis of SAMS and AN. increased hydration, which strongly correlated with the state of
Methods.– Presentation of a clinical case and literature review using malnutrition. BIA analysis offers more precise monitoring of mal-
PubMed database, with the following keywords: “anorexia ner- nourished patients and provides significant opportunity to assess
vosa” and “mesenteric superior artery”. the dynamics of (1) systemic repair of damaged cell membranes
Results.– C., female, 16 years old, single, with no history of previous and (2) improvement of cellular metabolism.
psychiatric illness. Referred to the eating disorder consultation for Disclosure of interest.– The authors have not supplied a conflict of
food restriction, significant weight loss and fear of weight gain. She interest statement.
described postprandial infarction and nausea. Deny any purgative
or compensatory behaviors.
As she presented an macroscopic haematuria, an abdominal E-PP0470
ultrasound was preformed, which revealed a reduction of the aorto- Disgust sensitivity and self-disgust are
mesenteric angle (10◦ ) and compression of the left renal vein
increased in anorexia nervosa
(Nutcracker Syndrome).
Conclusions.– In AN patients, SAMS might be a consequence and inpatients
maintenance factor. The rapid weight loss increases the likelihood E. Kot1 , K. Kucharska2*
1 Institute of Psychiatry and Neurology, Neuroses, Personality and
of duodenal compression by reducing the fat layer that protects the
superior mesenteric artery, which is associated with nausea, vomit- Eating disorders, Warsaw, Poland; 2 Institute Psychiatry and
ing, epigastric pain and gastric distension, that may be perpetuators Neurology, Department of Neuroses, Personality Disorders, and
of food restriction. Eating Disorders, Warsaw, Poland
interest statement. Background and aims.–
Introduction.– Disgust is the key element of adaptive mechanism
leading to cessation of the consumption of toxic substances. This
emotion might have a significant role in AN, particularly in relation
to food and abnormal eating behaviours. Moreover, disgust directed
towards self may be an element of AN psychopathology and also
wider disturbances in the processing of this emotion.
Objectives.–The study aimed to assess sensitivity to stimuli that
arouse disgust (disgust sensitivity), the level of disgust directed
towards self (self-disgust), and their relationship with symptoms E-PP0472

of eating disorders and anxiety in AN. Metabolomic signature of anorexia
Methods.– 63 Polish females: 30 AN inpatients and 33 HCs com-
nervosa
pleted Disgust Scale–Revised (DS-R) and Self-Disgust Scale (SDS),
F. Marciello1* , J. Troisi2 , A.M. Monteleone1 , R. Dalle Grave3 , G.
Eating Disorder Inventory (EDI), and State-Trait Anxiety Inventory
Corrivetti2 , A. Colucci2 , P. Monteleone4
(STAI). 1 Campania Region University “Luigi Vanvitelli”, Department of
Results.– AN patients showed increased disgust sensitivity (p < .05)
Psichiatry, Naples, Italy; 2 European Biomedical Research Institute of
and increased self-disgust (p < .001) compared to HCs. In AN group
Salerno EBRIS, Department of Neuroscience, Salerno, Italy; 3 Villa
there were significant positive correlations between self-disgust
Garda Hospital, Department of Eating and Weight Disorders, Verona,
and trait-anxiety, and between self-disgust and the severity of
Italy; 4 University of Salerno, Department of Medicine Surgery and
eating disorders symptoms. Trait-anxiety and EDI ineffectiveness
Dentistry- Section of Neuroscience, Salerno, Italy
subscale were the significant predictors of self-disgust in AN group * Corresponding author.
(r2 = .64).
Conclusions.– Patients exhibit impairments in disgust perception Background and aims.– The gut microbiota contributes to the
reflected in increased disgust sensitivity and self-disgust. Only self- breakdown of dietary costituents and produces an array of bioac-
disgust is related to the severity of eating disorders symptoms and tive metabolic products, which may affect human behavior and
the anxiety. These results show that altered disgust processing may brain regulation. The assessment of fecal metabolites through a
be a significant element of AN psychopathology and that it could metabolomic approach may help to obtain an overall picture of
be potentially addressed in therapeutic process. metabolic changes associated with human diseases and to identify
Disclosure of interest.– The authors have not supplied a conflict of possible biomarkers.
interest statement. Metabolomic signature of Anorexia Nervosa (AN) has not been
deeply investigated, although changes in metabolomics are likely
occurring because of the deranged eating behavior.
E-PP0471 Methods.– In this study we analyzed the fecal metabolomic pro-
Perfectionism in patients with eating file of 23 women with AN, before (T0) and after short-term weight
disorders and their parents recovery (T1), compared it with that of 20 healthy controls.
T. Santos1 , R. Leite1* , T. Pereira2 , C. Marques2 , N. Madeira2 , A. Results.– Nine metabolites (cadaverine, cycloserine, N-acetyl
Macedo2 ethylenediamine, steric acid, coprostanol, propionic acid, linoleic
1 Baixo Vouga Hospital Centre, Psychiatry and Mental Health acid, lactic acid, methyl ketobuthyric acid) were higher in AN
Department, Aveiro, Portugal; 2 Faculty of Medicine, University of patients at T0 compared to T1 and healthy controls; 4 metabolites
Coimbra, Psychological Medicine Department, Coimbra, Portugal (fucose, xylose, rhamnose, arabinose) were lower in AN women at
* Corresponding author. T0 compared to T1 and to controls.
Conclusions.– These findings suggest that a specifc metabolomic sig-
Background and aims.– Patients suffering from Eating Disorders, nature is present in acute pahse of AN. The extent to which these
particularly Anorexia Nervosa, have been traditionally considered metabolomic changes represent possible biomarkers of AN remains
as possessing high levels of perfectionism. The conceptualization of to be determined.
the personality construct has evolved, leading to the formulation Disclosure of interest.– The authors have not supplied a conflict of
of distinct subdimensions, with different underlying mechanisms, interest statement.
including family functioning and parenting styles. The aim of this
study is to compare the levels of perfectionism and its dimensions
in children and their parents in a clinical sample and a students E-PP0473
sample, and to determine the existence of correlation between Trauma, alexithymia and binge eating
parental perfectionism and their children. P. Correia1 , M. Marques2* , S. Soares1 , A.C. Ribeiro1 , P. Silva1 , C.
Methods.– Biographic data was collected from children (n = 17) and Alves1 , S. Simões3 , L. Lemos3 , B. Rodrigues Maia4
their parents, in both samples. The Multidimensional Perfectionism 1 Miguel Torga Higher Institute, Research and Development
Scale was applied to all participants. Department, Coimbra, Portugal; 2 Miguel Torga Higher Institute
Results.– It was obtained a significant correlation between total ISMT, Coimbra, Portugal; 3 Miguel Torga Higher Institute, Research
perfectionism and self-oriented perfectionism in patients with and Development Department ISMT, Coimbra, Portugal; 4 The
Anorexia nervosa and other-oriented perfectionism in mothers Catholic University of Portugal, Regional Centre, Braga, Portugal
(r = .765, p = .016; r = .907, p = .001, respectively). There was also * Corresponding author.
observed a significant negative correlation between total perfec-
tionism and self-oriented perfectionism in patients with Bulimia Background and aims.–
Nervosa and paternal other-oriented perfectionism (both r = - Background.– Binge eating disorder was recently recognized as a
.783, p = .022). Regarding students group, only others-oriented clinical entity in the diagnostic manuals. More studies are needed
perfectionism significantly correlated between children and moth- exploring the different correlates of binge eating symptoms.
ers (r = .579, p = .015). In an inter-group comparison, significantly Aims.– Explore associations between and the predictive role of hav-
higher levels of socially prescribed perfectionism in patients with ing experienced traumatic experiences and of alexithymia and/to
Bulimia Nervosa were found. binge eating symptoms.
Conclusions.– The results presented suggest a parental transmission Methods.– 421 participants from the general population and col-
of perfectionism in patients with Eating Disorders, with differ- lege students (female, n = 300; 71,3%; mean age = 30,7, SD = 11,51)
ent patterns according to subgroups studied. Results also suggest responded to the Traumatic Events Checklist, the Binge Eating Scale
that patients with Bulimia Nervosa have higher levels of externally and the Toronto Alexithymia Scale-20.
imposed perfectionism. Further studies are needed focusing on the Results.– Binge eating prevalence was similar to values found
parents-children dynamics in families of patients with Eating Dis- in other Portuguese studies. There was a significant association
orders. between body mass index (BMI) and binge eating total score, in both
Disclosure of interest.– The authors have not supplied a conflict of genders. Only in the female subsample, reported sexual trauma,
interest statement. family trauma and total of traumatic experiences showed associa-
tions with the binge eating total score. In both genders, the binge
eating total score correlated with difficulties in identifying and
describing feelings (TAS-20). In the female subsample women the Background and aims.– People affected by psychiatric disorders
binge eating total score also correlated with the external thinking and reporting childhood trauma exposure are characterized by
style (TAS-20). Women that reported being overweight or having more severe psychopathology and specific neurobiological alter-
obesity in childhood presented current higher binge eating levels. ations. Altered stress reactivity is a potential pathway that may
The BMI, the total of traumatic experiences and the difficulty in confer maltreated children an increased vulnerability to adulthood
identifying feelings significantly predicted the binge eating total psychopathology. Although early adverse experiences and inter-
score. personal stress have been recognized as potential risk factors for
Conclusions.– This study confirms the role of BMI as a correlate of anorexia nervosa (AN), no study has investigated so far the psy-
binge eating and shows that the number of traumatic experiences chosocial stress reactivity in maltreated AN patients. Therefore,
and the presence of higher levels of alexithymia are associated with we aimed to assess emotional and cortisol responses to an acute
binge eating symptoms. psycho-social challenge in AN patients reporting childhood trauma
Disclosure of interest.– The authors have not supplied a conflict of exposure.
interest statement. Methods.– Twenty-four AN women and 17 healthy women were
included in the study. Patients were classified as maltreated (Mal)
or non-maltreated (noMal) according to their Childhood Trauma
E-PP0474 Questionnaire scores. Participants underwent the Trier Social Stress
Eating disorders in frontotemporal Test (TSST): saliva samples were collected throughout the test in
dementia order to measure cortisol levels while the emotional response was
M. Mendes* , R. Fernandes, D. Pereira, M. Moreno, S. Nascimento measured by the state scale of the State-Trait Anxiety Inventory.
Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisboa, Portugal Results.– Mal AN women (n = 12) exhibited a blunted cortisol
* Corresponding author. response to TSST, compared to both healthy subjects and noMal
patients (n = 12). Moreover, even though pre-TSST anxiety levels in
Background and aims.– Frontotemporal dementia (FTD) is a progres- both Mal e noMal patients were enhanced, Mal AN patients dis-
sive neurodegenerative disorder that is frequently associated with played a reduced anxiety increase after TSST as compared to either
dietary changes and eating habits, particularly in the behavioral noMal patients or healthy women.
variant of FTD (bvFTD). These changes in eating behavior can repre- Conclusions.– Our results show a deranged biological and emotional
sent a challenge for the caregivers to guarantee adequate nutrition, response to an acute social stress in AN patients with childhood
posing an important threat to the global state of health of FTD trauma exposure, supporting the idea of a maltreated ecopheno-
patients. type in AN.
Objectives.– To review the current literature on the main character- Disclosure of interest.– The authors have not supplied a conflict of
istics of eating disorders in FTD, their underlying physiopathology interest statement.
and therapeutic strategies.
Methods.– A search was conducted using the database “pubmed”
with the key words “binge eating”, “eating disorders”, “frontotem- E-PP0476
poral dementia” and “frontotemporal degeneration”. Insecure attachment and social stress
Results.– Changes in eating behavior in bvFTD include, as describes vulnerability: an experimental study
in the International Consensus Criteria for bvFTD, altered food pref-
in adult people with eating disorders
erences (frequently with cravings for carbohydrates), binge eating,
F. Pellegrino1* , V. Ruzzi1 , G. Patriciello1 , R. Amodio1 , M. Cimino2 ,
increased consumption of alcohol or cigarettes and oral exploita-
A.M. Monteleone1
tion or consumption of inedible objects, with studies suggesting the 1 University of Campania “Luigi Vanvitelli”, Psychiatry, Naples, Italy;
involvement of orbitofrontal–insular–striatal brain networks in its 2 University of Salerno, Medicine- Surgery and Dentistry “Scuola
physiopathology, as well as hypothalamic dysregulation. While the
Medica Salernitana”- Section of Neuroscience, Salerno, Italy
use of SSRIs has been shown in some studies to help control eat- * Corresponding author.
ing behavior alterations, behavior and environmental strategies are
preferred. Background and aims.– Vulnerability to interpersonal stress has
Conclusions.– A better understanding of the phenomenology of eat- been widely recognized as an important risk factor for Eating Disor-
ing disorder in FTD and its neurological correlates is needed as it der (ED) psychopathology. Adult insecure attachment may involve
may represent an important step in its management, potentially dysregulated emotional, biological and behavioural strategies to
avoiding health consequences of overeating and the risks of hyper- cope with social stressors. Although the high prevalence of inse-
orality regarding inedible objects in this population of patients. cure attachment in people with EDs, no study, to date, has explored
Disclosure of interest.– The authors have not supplied a conflict of the impact of attachment dimensions on the individual’s response
interest statement. to a psychosocial stressor in ED patients. We investigated the
hypothalamic-pituitary-adrenal (HPA) axis response and the emo-
tional reactivity to an acute interpersonal challenge in ED patients
E-PP0475 in relation to their attachment dimensions.
Deranged response to an acute Methods.– Fifty-two ED women (29 with anorexia nervosa and 23
psychosocial stress in patients with with bulimia nervosa) underwent an acute psycho-social stressor,
anorexia nervosa reporting childhood the Trier Social Stress Test (TSST). They filled in the Experience in
Close Relationship (ECR) questionnaire to assess their adult attach-
maltreatment: evidence for a
ment style. Saliva samples were collected, throughout the task, to
“maltreated ecophenotype”? measure cortisol levels. The emotional response was investigated
G. Patriciello1* , F. Pellegrino1 , V. Ruzzi1 , G. Cascino2 , V. Caivano1 , by means of the State-Trait Anxiety Inventory state scale.
M. Raia1 , A.M. Monteleone1 Results.– Patients with high attachment anxiety and those with high
1 University of Campania “Luigi Vanvitelli”, Psychiatry, naples, Italy;
2 University of Salerno, Medicine- Surgery and Dentistry “Scuola
attachment avoidance scores displayed increased TSST-induced
cortisol production and higher anxiety levels, in comparison to
Medica Salernitana”- Section of Neuroscience, Salerno, Italy those with low attachment anxiety or avoidance.
Conclusions.– Present findings confirm that attachment contributes
to modulate the emotional and biological reactivities to an acute
social threat in ED patients. Future studies are needed to directly
assess the attachment-mediated changes in the interpersonal Disorders (EDs). However, their interplay in determining ED psy-
stress responses on ED psychopathology and behaviours. chopathology has been poorly investigated.
Disclosure of interest.– The authors have not supplied a conflict of We aimed to explore the role of attachment to parents and early
interest statement. traumatic experiences in eating-related psychopathology.
Methods.– Fifty-seven patients with anorexia nervosa (AN), 43 with
bulimia nervosa (BN) and 77 age-matched healthy women were
E-PP0477 enrolled in the study and were asked to complete the Childhood
Clinical and biological aspects of Trauma Questionnaire, the Parental Bonding Instrument and the
eating behaviors in depressive Eating Disorder Inventory-2.
Chi-square test and regression analyses with a moderation model
patients with antidepressant-induced
were performed to investigate the interplay between childhood
weight gain trauma, parental bonding and ED psychopathology.
G. Rukavishnikov1* , G. Mazo1 , A. Kibitov2 , N. Neznanov3 Results.– Patients reported more insecure parental attachment and
1 Bekhterev National Medical Research Center for Psychiatry and higher levels of childhood maltreatment compared to healthy sub-
Neurology, Endocrinological Psychiatry, Saint-Petersbrug, Russia; 2 jects, with no significant differences between AN and BN groups.
Serbsky National Medical Research Center on Psychiatry and Maltreatment events were more prevalent among those patients
Addictions, Laboratory of Molecular Genetics, Moscow, Russia; 3 with low levels of care and high levels of control parenting styles.
Bekhterev National Medical Research Center for Psychiatry and Moderation analyses revealed that the interaction between low
Neurology, Geriatric Psychiatry, Saint-Petersbrug, Russia and, possibly, medium levels of emotional abuse with high mater-
nal control increased the prediction of social insecurity in patients
Background and aims.– Antidepressant-induced weight gain in cer- with EDs.
tain patient cohorts may lead to further morbidity and social Conclusions.– These findings suggest a possible interaction between
deprivation. These devastating consequences of treatment could be parental bonding and childhood trauma events in promoting vul-
the result of certain biological damage and eating behavior changes nerability to social insecurity, one of the most central dimensions
behind it. The aim of the present study was to analyze the clinical of ED psychopathology. Therefore, our study corroborates the
and biological aspects of eating behaviors in patients with major importance of psychotherapeutic interventions focusing on the
depressive disorder who received antidepressant treatment. association between early experiences and interpersonal problems.
Methods.– Data presented in the study were obtained from Disclosure of interest.– The authors have not supplied a conflict of
89 outpatients with major depression (74% females, mean interest statement.
age–45,04 ± 11,4 years) at baseline and after 6 months of antide-
pressant therapy (SSRI, TCA). Clinical evaluation (weight, BMI,
E-PP0479
weight gain), psychometric instruments (HDRS-17, The Dutch
Eating Behavior Questionnaire) and laboratory panel (thyroid hor- Pica in an adolescent with attention
mones, sex steroids, leptin, insulin, lipidogram) were used in the deficit hyperactivity disorder
assessment. L. Sahli* , S. Bourgou, Z. Azouz, M. Hamza, F. Charfi, A. Belhadj
Results.– The analysis of received data showed that emotional Monji Slim Hospital, Child and adolescent psychiatry, Tunis, Tunisia
eating was the most prevalent type (42%) of eating behavior at base-
line and restrictive eating was the most prevalent eating behavior
Background and aims.– Pica is defined as the persistent eating
type (28%) after 6 months of antidepressant therapy. Patients with
of nonnutritive substances for a period of at least one month
antidepressant-induced weight gain (5% increase in body mass dur-
in a developmentally inappropriate and culturally unacceptable
ing treatment) tend to have higher scores for external eating after
manner. Causative factors include pregnancy, stress, mental retar-
treatment compared to patients with increased body mass at base-
dation, psychotic disorders and nutritional deficiencies.
line. Patients with restrictive eating at baseline showed significant
Methods.– H.L, a 12-year-old boy, referred to our consultation in the
increase in insulin (p < 0,05) and prolactin (p < 0,01) levels after 6
child psychiatry department of Monji Slim Hospital by an adult psy-
months of treatment, while in patients with emotional eating pro-
chiatrist with complaint of eating the plastic of headphone wires
lactin (p < 0,01) and leptin (p < 0,01) levels were increasing.
and his fingers’ skin.
Conclusions.– Increase in specific eating scores and changes in hor-
He reported eating and chewing plastic of headphones and mouse
monal levels during treatment support the idea of certain high risks
wires, the collars of his clothes, plastic caps and kis fingers’ skin.
patient profiles for antidepressant-induced weight gain.
He described this habit as involuntary happening when he is dis-
tracted.
interest statement.
He reported having since early childhood inattention, hyperactivity
that decreased with age and impulsivity.
E-PP0478 He did not describe any obsessive, compulsive, anxiety and/or
depressive symptoms. He described addiction to the internet. The
Parental attachment and early
interview with the mother revealed a history of maternal depriva-
traumatic experiences: which possible tion.
role in eating disorder His neuropsychological testing revealed above-average intelli-
psychopathology? gence. There was no history of pica among his family members
V. Ruzzi1* , G. Patriciello1 , F. Pellegrino1 , G. Cascino2 , F. Zinno1 , A. (figure 1).
Vece1 , A.M. Monteleone1
1 University of Campania “Luigi Vanvitelli”, Psychiatry, Naples, Italy; 2
University of Salerno, Department of Medicine, Surgery and Dentistry

“Scuola Medica Salernitana”- Section of Neurosciences, Salerno, Italy
Background and aims.– Insecure attachment and childhood trauma

experiences have been found to play pivotal roles in Eating
E-PP0481
Validation of the physical appearance
comparison scale-revised (PACS-R) in
a Spanish population
C. Senín-Calderón1* , J.F. Rodríguez-Testal2
1 University of Cádiz, Department of Psychology, Puerto Real, Spain; 2
University of Seville, Personality, Evaluation and Psychological
Treatment Department, Seville, Spain
Background and aims.– Recent studies have found a strong rela-

tionship between the comparison of physical appearance and
dissatisfaction with body image. In this study, we proposed to val-
idate the Physical Appearance Comparison Scale-Revised (PACS-R)
in Spanish, finding its reliability indicators and evidence of validity
and explore its usefulness for predicting eating pathology and body
dysmorphia.
Methods.– The sample consisted of 267 participants (70% women)
aged 18 to 30 (Mage = 21.94, SD = 2.87). The PACS-R Scale, the Socio-
cultural Attitudes Towards Appearance Questionnaire (SATAQ-4),
Eating Attitude Test (EAT-26), and Body Dysmorphic Disorder
Questionnaire (BDDQ) were administered.
Figure 1. PICA IN AN ADOLESCENT WITH ATTENTION DEFICIT
Results.– Exploratory Factor Analysis found a one-dimensional
HYPERACTIVITY DISORDER
structure of the DCQ (Kaiser-Meyer-Olkin = .93, p < .001). The Cron-
Results.– He was diagnosed Pica and ADHD (combined type) accord- bach’s alpha was .95. There was a strong relationship between the
ing to DSM-5 criteria. PACS-R and eating pathology (r = .627), fat internalization (r = .635)
Conclusions.– This case illustrates the possible comorbidity of pica and body dysmorphia (r = .686). Multiple linear regression analysis
and ADHD in an adolescent with a history of maternal deprivation. found that the PACS-R was a significant predictor of eating pathol-
Further studies are needed to clarify the association of ADHD and ogy (ˇ = .28, p < .001) and body dysmorphia (ˇ = .47, p < .001). After
this eating disorder. controlling for the BMI and the SATAQ-4 subscales, the PACS-R was
Disclosure of interest.– The authors have not supplied a conflict of the second significant predictor of eating pathology after fat inter-
interest statement. nalization (SATAQ-4), representing 4% of the variance. The PACS-R
was the best predictor of dysmorphic symptomatology, explaining
up to 11% of the variance.
E-PP0480 Conclusions.– The PACS-R scale is a valid and reliable measure for
Dysmorphic concerns: identification evaluating the comparison of physical appearance and is useful for
predicting eating pathology and especially, body dysmorphia.
of predictor variables
1 interest statement.
University of Cádiz, Department of Psychology, Puerto Real, Spain; 2
University of Seville, Personality, Evaluation and Psychological
Obsessive compulsive
Background and aims.– Dysmorphic concerns refer to exaggerated symptomatology in female adolescent
worry about a slight or imaginary flaw in one’s physical appearance, inpatients with restrictive compared
usually not observable by others. This study intended to explore
what cognitive and emotional variables are predictors of dysmor-
to binge-purge eating disorders
D. Stein1,2* , Y. Lewis3 , T. Gilon Mann4 , A. Enoch-Levy4 , G.
phic concerns in a population with no psychopathology
Dubnov-Raz2,5 , D. Gothelf2,5 , A. Weizman2,6
Methods.– There were 322 participants (67.7% women) aged 18 to 1 Director, Outpatient Service for the Treatment of Eating Disorders in
30 years (Mage = 22.15, SD = 2.91). The dysmorphic concerns ques-
Children and Adolescents, Pediatric Psychosomatic Department, Safra
tionnaire (DCQ), the RRS Ruminative Responses Scale, the REF
Children’s Hospital, Tel Hashomer, Israel; 2 Sackler Faculty of
Referential Thinking Scale, the GHQ-28 questionnaire (evaluates
Medicine, Tel Aviv University, Tel Aviv, Israel; 3 Hanotrim Eating
symptoms of anxiety, depression, somatization and social dysfunc-
Disorders Unit, Shalvata Mental Health Center, Hod Hasharon, Israel;
tion) and Type D personality (evaluates negative affect and social 4 Pediatric Psychosomatic Department, Safra Children’s Hospital,
inhibition) were administered.
Sheba Medical Center, Tel Hashomer, Israel; 5 Safra Children’s
Results.– A stepwise multiple liner regression analysis was per-
Hospital, Sheba Medical Center, Tel Hashomer, Israel; 6 Felsenstein
formed. Of all the variables entered in the model, rumination
Medical Research Center and Geha Mental Health Center, Rabin
(ˇ = .304, p < .001), ideas of reference (ˇ = .142, p < .01), somatic
Medical Center, Petah Tiqva, Israel
symptoms (ˇ = .123, p < .05) and negative effect (ˇ = .146, p < .01) * Corresponding author.
predicted dysmorphic concerns, explaining 28% of the variance.
Conclusions.– The tendency to ruminate and interpret everything Background and aims.– Strong relationships exist between obses-
that surrounds one as having to do with oneself along with person- sive compulsive disorder (OCD) and eating disorders (EDs). The aim
ality characteristics tending to be somaticizing and negative affect, of the study was to investigate whether OC symptoms would be
enable an at-risk dysmorphic body disorder profile to be identified, expressed differently in different ED types.
anxiety and depressive symptomatology not being as relevant. Methods.– Ninety-four female adolescent inpatients with restrict-
Disclosure of interest.– The authors have not supplied a conflict of ing anorexia nervosa (AN-R), 67 with binge/purge AN (AN-B/P),
interest statement. and 48 with bulimia nervosa (BN) were assessed on admission and
discharge using the Yale-Brown Obsessive-Compulsive Scale (Y-
BOCS), Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS), Eating E-PP0484

Attitude Test-26 (EAT-26), Beck Depression Inventory (BDI), and Cannabinoid hiperemesis syndrome
State-Trait Anxiety Inventory (STAI).
in a psychiatric emergency setting
Results.– On admission, patients with AN-B/P exhibited higher
T. Ferreira* , S. Dehanov, I. Figueiredo, C. Oliveira, M. Morins, T.
scores on the Y-BOCS, YBC-EDS, EAT-26 and BDI in comparison to
Maia
patients with AN-R or BN. A significant improvement on all psy-
Hospital Prof. Doutor Fernando da Fonseca, Department of
chometric variables from admission to discharge was found for all
Psychiatry, Amadora, Portugal
participants taken together. Nonetheless, patients with AN-B/P and * Corresponding author.
or BN, showed a greater improvement on Y-BOCS, BDI and STAI
than patients with AN-R, whereas no between-group difference Background and aims.– Cannabinoid hyperemesis syndrome (CHS)
was fund for YBC-EDS and EAT-26. is defined as a pattern of recurrent and cyclic vomiting, nausea and
Conclusions.– Obesessionality is more severe in acutely ill AN-BP abdominal discomfort in relation with chronic cannabis use. One
patients than in patients with AN-R and BN, whereas a greater peculiar feature is relief with hot baths. There are some proposed
improvement in obsessionality from the acutely ill to the stabilized diagnostic criteria, such as those of Simonetto et al. (2012). Emer-
ED condition is found in patients with binge/purge in comparison gency department presentations range from dehydration to more
to restrictive pathology. serious consequences (i.e. kidney damage) or even death. Our aim
Disclosure of interest.– The authors have not supplied a conflict of is to present a case report of a patient with CHS in a psychiatric
interest statement. emergency setting.
Methods.– Review of the clinical case and literature.
Results.– A 27-year-old woman with a history of anxiety disor-
der, medicated with sertraline 50 mg/day, was admitted to the
E-Poster Presentation: Emergency Psychiatry emergency department for recurrent episodes of persistent watery
vomiting, nausea and abdominal pain. No medical cause was
identified and there was no relief with metoclopramide. Consid-
E-PP0483 ering psychogenic vomiting, psychiatric evaluation was requested.
Clinical and socio-demographic During interview, it was found that the episodes of vomiting
description of psychiatric patients were recurrent and progressively more frequent, and started with
the beginning of cannabinoid consumption in college (about 3
who are admitted in the Emergency
units/day). She did not identify causable factors, but noted that
Department at the University Hospital having a “hot bath” eased her symptoms. The patient responded
Center ‘Mother Theresa’, Tirana to olanzapine.
H. Agaj1* , K. Kola1 , F. Elezi2 , E. Sotiri3 Conclusions.– In this case, 9 of the 11 diagnostic features proposed
1 Resident in General Psychiatry, Neuroscience Department, by Simonetto et al (2012) were present. Given the widespread
Psychiatric Service, University Hospital Center of Tirana ‘Mother use of cannabinoids, it’s not surprising that the appearance of
Theresa’, Tirana, Albania; 2 Head of Emergency Psychiatry Unit, patients with CHS increases, although it may be under-recognized.
Neuroscience Department, Psychiatric Service, University Hospital Treatment consists of support measures, off-label pharmacologi-
Center of Tirana ‘Mother Theresa’, Tirana, Albania; 3 Psychiatrist, cal agents (e.g. capsaicin, benzodiazepines, antipsychotics) and the
Neuroscience Department, Psychiatric Service, University Hospital cessation of cannabis use.
Center of Tirana ‘Mother Theresa’, Tirana, Albania Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
Background and aims.– Psychiatric diseases can be manifested with

somatic symptoms for which patients may seek their first help at E-PP0485
the Emergency Department.
Cerebral and genetic peculiarities of
This study aims at determining the frequency, socio-demographic
and clinical data of patients evaluated with psychiatric diagnoses affective and cognitive disorders
in the Emergency Department during January–June 2018. following exposure to ionizing
Methods.– This is a retrospective descriptive study of emergency radiation as a result of the chornobyl
department records. catastrophe
Results.– There have been 2671 patients with psychiatric evalua- K. Loganovsky1* , M. Bomko1 , I. Abramenko2 , K. Kuts1 , N. Belous2 ,
tion, which is 6.6% of all patients admitted. 69.3% are females and S. Masiuk3 , M. Gresko1 , T. Loganovska1 , K. Antypchuk1 , I.
30.7% males. The mean age of patients was 35.68 years old and Perchuk1 , G. Kreinis1 , S. Chumak1
the most frequent age-group was 13–25. 42.7% of these patient 1 State Institution «National Research Center for Radiation Medicine
were employed, 36.5% are unemployed, 14.8% are students and of the National Academy of Medical Sciences of Ukraine», Radiation
6% fell in other categories. The hours with the highest frequency Psychoneurology, Kyiv, Ukraine; 2 State Institution «National
were 22:00–24:00 and those with the lowest frequency were Research Center for Radiation Medicine of the National Academy of
06:00–08:00. The most common diagnosis was Anxiety making up Medical Sciences of Ukraine», Clinical Immunology, Kyiv, Ukraine; 3
for 83.9% of all diagnoses. The most common therapy is intramus- State Institution «National Research Center for Radiation Medicine of
cular diazepam, 82.1%. Only 4.5% of the patients were referred for the National Academy of Medical Sciences of Ukraine», Dosimetry
further specialized psychiatric care. and Radiation Hygiene, Kyiv, Ukraine
Conclusions.– Patients evaluated with psychiatric diagnoses dur- * Corresponding author.
ing the time period January–June 2018 are mostly females, mostly
employed, diagnosed with Anxiety and treated with diazepam in Background and aims.– In spite of affective and cognitive disorders
the majority of cases. increased following the Chornobyl catastrophe, their pathogene-
Disclosure of interest.– The authors have not supplied a conflict of sis is unclear. The objectives are to study neuropsychiobiological
interest statement. basis of affective and cognitive disorders in remote period of the
Chornobyl catastrophe taking into account certain gene polymor-
phisms.
Methods.– The randomized sample (n = 198) of male Chornobyl E-PP0487

catastrophe clean-up workers (liquidators) and 110 non-exposed The first-time encounter with the
controls were examined with neuropsychiatric, neuro- and psy-
patient in psychiatric emergency
chometric, neuropsychological, neuro- and psychophysiological
methods. The genotypes of the serotonin transporter gene SLC6A4
room: how welcome?
were determined by the 5-HTTLPR and rs25531 polymorphisms. M. Meriaux* , J. Denis
Results.– Risk of neuropsychiatric pathology increases (Pv < 0.001) University of Mons, Systemic and Psychodynamic Clinical Psychology
with radiation dose. Cognitive impairment at doses >0.3 Sv is Department, Mons, Belgium
dose-dependent (r = 0.4–0.7; P = 0.03–0.003). Depression and neu-
rocognitive deficit are more severe at higher doses (≥50 mSv). Background and aims.– Literature often highlights the importance
Disturbed brain information processes lateralized to the Wer- of reception in first encounters in the field of health. It presence
nicke’s area are observed at doses >50 mSv. Carriers of intermediate are often essential to the establishment of the relationship and the
and low-level genotypes (LA/S, LA/LG, LG/LG, LG/S, S/S) of SLC6A4 therapeutic alliance. To addition, it is obvious that first encoun-
have more depression and tend to increased cognitive and ters in emergency departments between healthcare professional
stress-related disorders. Onset of depression in carriers of inter- and patient are often problematic, marked by misunderstandings
mediate and low-activity genotypes occurs much earlier (Log-Rank and dissatisfaction. There is a documented paucity of research in
Test = 4.43, P = 0.035) in comparison with high-performance geno- this substantive area and no extant theory to guide caregiver in
type LA/LA. their practice during first-time encounters. We aimed to show how
Conclusions.– Radiation-induced dysfunction of the cortico-limbic a qualitative method may reveal experiences about how profes-
system in the left dominant brain hemisphere with involvement of sionals explained their clinical practice in reception context. This
hippocampus is considered to be the key cerebral basis of postra- paper presents a reception model based on experts’ point of view
diation brain damage. There is association of 5-HTTLPR and rs25531 in Psychiatric Emergencies Room (PER).
polymorphisms of SLC6A4 gene with depression and cognitive dis- Methods.– A qualitative approach called, Grounded Theory Method-
orders following exposure to ionizing radiation as a result of the ology (GTM) (Glaser & Strauss, 1967), was undertaken in order to
Chornobyl catastrophe. identify practice during the first moments of care. Semi-structured
Disclosure of interest.– The authors have not supplied a conflict of interviews were conducted and data were analyzed with the con-
interest statement. stant comparative method. The study was conducted in Psychiatric
Emergency Room.
Results.– Reception is a relational approach. Encounter requires
E-PP0486
presence, reflection, adaptation, time and availability to welcome
Outcomes of a terrorist attack: the other.
correlation between levels of Conclusions.– This study illuminates that clinicians and profession-
exposure to a terrorist attack and als in crisis intervention need guidelines to better improve their
mental health disorders aftermath therapeutic interventions in first-time encounters and so the “con-
D.W. Mazurkiewicz tinuity of care“.
St. Mark’s Place Institute for Mental Health, Mental Health and Disclosure of interest.– The authors have not supplied a conflict of
Chemical Dependency, New York, USA interest statement.
Background and aims.– Introduction: The threat of terrorism in

the European Union has grown. Understanding the correlation E-PP0488
between the level of exposure to a terrorist attack and mental The impact of Safe Haven’s on
health disorders, can be helpful in the process of planning treat- psychiatric admission and detentions
ment and therapy for victims of mass terrorism. D. Mirfin1* , G. Belam2 , S. Masawi3
Objective.– Effects of direct and indirect mass terrorism on mental 1 Surrey and Borders Partnership NHS Foundation Trust, Liaison
health disorders. Psychiatry, Chertsey, United Kingdom; 2 Surrey and Borders
Methods.– It was conducted methodological and statistical research Partnership NHS Foundation Trust, Surrey Heath CMHTOP, Frimley,
of the data derived from medical and psychological records of the United Kingdom; 3 Surrey and Borders Partnership NHS Foundation
WTC 9/11 terrorist attack victims. Among others, following data Trust, Home Treatment Team, Surrey Heath and North East
were examined: the type of clinical diagnoses and symptoms; the Hampshire, Chertsey, United Kingdom
length of contact with the stressor on the incidence of the respec- * Corresponding author.
tive symptoms; the onset of the first symptoms; duration time of
individual or group psychological therapy. Background and aims.– Safe Haven’s are crisis cafe’s and there are
Results.– The number of symptoms increased along with increas- five within the county. These were designed with the intent of
ing contact time with the stressor. The gender criterion is related to improving the delivery of crisis care and reducing the rate of psy-
the occurrence of differences in the types of symptoms of mental chiatric admissions, detentions and presentations to Accident and
disorders. The patients who survived the terrorist attack and/or the Emergency. They are staffed with a psychiatric nurse and can enable
persons who observed the incident exhibit fewer traumatic symp- direct referrals to secondary mental health care. The aim is to assess
toms and a lower percentage of suicidal thoughts in comparison the impact the introduction of Safe Haven has had on high intensity
with the group of individuals working as rescuers or cleaning staff users on outcomes including psychiatric admissions, detentions
in the area after said attack. The positive effect of protracted court under the Mental Health Act and referrals to liaison psychiatric
cases in legal proceedings for compensation on the maintenance services.
and development of psychopathology was noted. Methods.– Records of those attending 2 Safe Haven’s were compiled.
Conclusions.– There is an urgent need to develop medical and The number of visits for each user was determined and the highest
psychological standards of conduct for situations related to mass intensity users were selected for the sample. The mental health
terrorist attack. It is necessary to protect not only direct victims, records were then compared before and after the Safe Haven had
but also first line of responders. opened. Data was collected on the number of detentions, number of
Disclosure of interest.– The authors have not supplied a conflict of hospital admissions and rate of referrals to Home Treatment Team
interest statement. and Liaison Psychiatry as well as demographics. This data was then
statistically analysed to determine if there had been a significant E-PP0490

difference in the outcomes before and after the introduction of Safe Clinical picture of intoxication with
Haven’s.
sodium azide
Results.– There were over 8000 visits over a 2year period which
S. Petrykiv1* , M. Arts2 , L. de Jongen3
involved over 800 individuals. Those who attended most frequently 1 Maastricht University Medical Center, Department of Clinical
had a difference in the rate of admissions, detentions and referrals
Pharmacy and Pharmacology, Maastricht, The Netherlands; 2 Mental
to liaison-psychiatry.
Health Care, Western North Brabant GGZ-WNB, Department of Old
Conclusions.– Safe Havens are an effective alternative to reduce the
Age Psychiatry and Neuropsychiatry, Halsteren, The Netherlands; 3
rate of admissions, detentions and referrals to Liaison Psychiatry
Leonardo Scientific Research Institute, Department of
and provide an effective alternative to A&E as a place of safety.
Neuropsychiatry, Groningen, The Netherlands
interest statement.
Background and aims.– Sodium azide (NaH3) is currently under con-
sideration for being a compound of euthanasia in the Netherlands.
E-PP0489 Since the compound is freely available on the market and intoxica-
Depression and alcohol abuse in tion with NaH3 can lead to tremendous consequences, we provide
combatants of antiterrorist operation an educational review on the known health effects of sodium azide
and radiation emergency survivovrs in humans in order to help the physicians to recognize the symp-
O. Napryeyenko1* , K. Loganovsky2 , N. Napryeyenko1 , T. toms and to treat the victims of autointoxication.
Loganovska2 , M. Gresko2 , N. Zdanevych2 Methods.– The authors conducted a systematic review of the lit-
1 Bogomolets National Medical University, Psychiatry and Narcology, erature from 1927 to 2017 on human exposure to sodium azide
Kyiv, Ukraine; 2 State Institution «National Research Center for and provided their toxicology expertise to explain the underlying
Radiation Medicine of the National Academy of Medical Sciences of mechanism of intoxication.
Ukraine», Radiation Psychoneurology, Kyiv, Ukraine Results.– NaH3 acts by inhibition of cytochrome oxidase through
* Corresponding author. irreversible binding to a heme cofactor. Most suicide attempts
with NaH3 occur by ingestion. NaH3 exhibits toxic effects at lev-
Background and aims.– Depression and alcohol abuse are els of exposure of > 0.5 mg/kg. Nonlethal doses range from 0.3 to
widespread among combatants of Antiterrorist operation/Joint 150 mg (0.004 to 2 mg/kg), while fatal doses occur with exposures
Forces Operation (ATO/JFO) in Donbass and Chornobyl catastro- of >10 mg/kg or =700 mg. Toxic effects correlate to the ingested
phe survivors. Objectives are to optimize the psychiatric care for dose and comprise physiological responses at the vascular level
ATO/JFO combatants and Chornobyl liquidators with depression from lower exposures (<700 mg) and those at or above are toxi-
and alcohol abuse through theoretical substantiation, development cological responses at the metabolic level. All reported individuals
and implementation new principles and algorithms for diagnosis, with hypotension for more than an hour died.
treatment and prevention. Conclusions.– Alike cyanide, NaH3 is highly toxic. Onset of hypoten-
Methods.– 160 ATO/JFO combatants and 81 Chornobyl catastro- sion within minutes or in less than an hour is indicative of a
phe survivors with depression associated with alcohol abuse pharmacological response and a benign course. Hypotension with
were comprehensively examined with clinical-anamnestic, socio- late onset (>1 hour) constitutes an ominous sign for death. There is
demographic, clinical psychopathological and somatoneurological, no specific antidote for sodium azide intoxication.
psychodiagnostic, neurophysiological and neuroimaging methods Disclosure of interest.– The authors have not supplied a conflict of
at 5 stages: (1) screening; (2) inclusion; (3) randomization; (4) interest statement.
treatment and (5) catamnestic (follow-up) observation.
Results.– In combatants depressive-hypochondric, asthenic-
depressive, and anxiety-depressive syndromes dominated. They E-PP0491
had personality deformation, irritative changes on EEG, and cere- Myxedema psychosis as the first
bral vessels changes. In survivors there is an excess of depression manifestation of an undiagnosed
with progressive course, personality changes with psychosomatic
Hashimoto Thyroiditis: a case study
pre-disposition, comorbidity with cerebrovascular pathology, neu-
D. Tsaklakidou* , K. Tournikioti, A. Douzenis
rocognitive deficits and high frequency (24%) of secondary alcohol
“Attikon” University General Hospital of Athens, 2nd Department of
abuse. Comprehensive social, psychological-psychiatric, medica-
Psychiatry of the University of Athens, Athens, Greece
tion and somatoneurological help on the basis of a biopsychosocial * Corresponding author.
paradigm was elaborated and successfully implemented.
Conclusions.– The depression and alcohol abuse comorbidity in Background and aims.– Myxedema psychosis is uncommon in
combatants and Chornobyl catastrophe survivors dramatically patients with primary hypothyroidism, while the most common
decreased their quality of life, increase the working days lost, dis- psychiatric symptoms are affective disorders. Only since the middle
ability and suicidal risk. The proposed diagnostic complex and of the 19th century have been described some cases of “myxedema
differentiated approaches to treatment, prevention and medical psychosis”.
and social rehabilitation may increase the level of medical care for Methods.– A 43-year-old man without psychiatric history was
the ATO/JFO combatants and Chornobyl catastrophe survivors with brought to the psychiatric emergency for new-onset aggression,
depression associated with alcohol abuse. paranoid behaviour, auditory hallucinations and severe sleep dis-
Disclosure of interest.– The authors have not supplied a conflict of turbances for 3 days. Initial test results showed a TSH level of >
interest statement. 100 ␮IU/ml (physiological level of 0.27–4.20). No other clinical or
laboratory abnormalities were found. A diagnosis of Myxedema
psychosis was established and patient was treated with thyroid
hormone and antipsychotic medication, with positive response.
After discharging the patient achieved a euthyroid state and
was without psychotic symptoms, despite the discontinuation of
antipsychotic treatment.
Results.– The connection between hypothyroidism and psychosis E-Poster Presentation: Epidemiology and Social
is probably related to the effect of thyroxine deficiency on neu- Psychiatry
rotransmission. Regarding the chronological sequence, psychotic
manifestations have been described after the onset of physical
symptoms. It seems also that the severity of the thyroid dysfunction
does not correlate with psychiatric symptoms. E-PP0493
Conclusions.– In the present case it is noteworthy that the primary Beyond the biopsychosocial aproach:
manifestation of hypothyroidism was an acute psychotic episode. It evolutionary models of depression
is therefore underlined, that thyroid abnormalities should be con- F. Almeida* , I. Murta
sidered in all patients presenting with altered mental status, as Centro Hospitalar e Universitário de Coimbra, Psychiatry Unit,
these changes can take place acutely or have an insidious onset. Coimbra, Portugal
This case helps to illustrate the importance of promptly recogniz- * Corresponding author.
ing and implementing treatment for reversible causes of psychosis

in an atypical presentation of a common medical condition. Background and aims.– Depression is the leading cause of disability
Disclosure of interest.– The authors have not supplied a conflict of worldwide, with an estimated prevalence of 322 million (4.4% of
interest statement. the world population). The common occurence and persistance of
such a phenomenon is difficult to explain. Evolutionary approaches
might be useful as overarching frameworks for unified models of
E-PP0492 depression and generate interesting hypotheses for research.
Changed legal framework regarding Methods.– A systematic review of the literature available was con-
ducted on Pubmed and the studies found were grouped according
the use of Physical restraints on to several hypotheses.
involuntarily committed patients in Results.– The review yielded the following hypothesis: psychic pain,
psychiatric hospitals in germany: how behavioral shutdown model, analytical rumination, rank theory,
do we deal with the situation? social risk hypothesis, honest signalling theory, bargaining the-
B.S. Voigtländer* , K.U. Scorl, T. Barth ory, social navigation theory, prevention of infection and the third
Klinikum Chemnitz gGmbH, Psychiatry- Behavioural Medicine and ventricle hypothesis. Additionaly, depression can be viewed as a
Psychosomatics, Chemnitz, Germany dysregulated adaptation regarding one of several of these potential
* Corresponding author. mechanisms. Each of these combine existing evidence regarding
behavioral, neurobiological and social aspects of depression.
Background and aims.– In the context of the judgment of the Federal Conclusions.– Evolutionary models may offer a way to combine
Constitutional Court of 24 July 2018 (2BvR 309/15; 2BvR 502/16) apparently disparate pieces of evidence on depression, be useful as
[1] the statutory regulations for the use of physical restraints on overarching frameworks for unified models of depression (Aaron T.
patients involuntarily committed subject to public law were spec- Beck et al., 2016) and generate interesting hypotheses for research.
ified: In the event of five-point or seven-point restraints of not Disclosure of interest.– The authors have not supplied a conflict of
merely short time period, a separate judicial decision is required, interest statement.
even if a judicial order of involuntary commitment in a psychiatric
hospital exists. Our objective is to find an appropriate concept for
coping with the “new situation” taking into consideration both legal E-PP0494
regulations and current clinical practice. Psychiatric repercussions of
Methods.– Firstly the treatment practice of our emergency psy- mandatory smoking cessation in a
chiatric unit was analysed by comparing the treatment of two
general hospital
patient groups (p1, p2) - the physically restrained treatment cases
A. Alonso Sanchez* , A. Álvarez, H. De la Red, E. Rodriguez, N. De
“with” (p1; n = 40) and “without” (p2; n = 90) involuntary commit-
Uribe, M. De Lorenzo, M. Gómez, C. Capella, E.M. Rodriguez, I. De
ment (excluding involuntary commitment by civil law). The study
la Montaña, J. Gonçalves, A. San Román
(2017) focused on socio-demographic patient data, treatment-
related data, and specific key figures by using a clinic-internal
Spain
standardized data collection method. * Corresponding author.
Results.– There were differences in average age (p1 = 40.5 years;
p2 = 36.9 years), gender distribution (p1 = 40/60; p2 = 29/71; Background and aims.– Smoking is totally prohibited in most of the
female/male), average length of stay in the clinic (p1 = 40.6 hospitals in the world. Abrupt cessation can lead to some mild to
days; p2 = 13.7 days), regarding main diagnosis-related distribution severe psychiatric repercussions.
(p1 = F10–F19:27.5%, F20–F29:27.5%, F30–F39:27.5%, other:17.5%; Methods.– We describe a case report of a patient admitted to the
p2 = F10–F19:53.9%, F20–F29:11.2%, F30–F39:10.1%, F40–F48:9.0%, surgery unit who presents disruptive behaviour after being told not
other:15.8%), and concerning the quality indicators [2] ‘Total Dura- to smoke.
tion of Restraint’ (p1 = 36.6 hrs; p2 = 14.2 hrs) and ‘Average Number Results.– The case consists of a male patient who has been smok-
of Restraint Events’ (p1 = 3.3; p2 = 1.3) Further key figures, e.g. ‘Rea- ing since he was fifteen. He never tried to quit tobacco and at the
sons for Restraint’,‘Type of Restraint’ were evaluated. moment of the admission, he was smoking close to forty cigarettes
Conclusions.– Discussions are currently taking place between the per day. In the hospital, he had to stop smoking abruptly. He felt
clinical experts and the competent judges. anxious, irritable and aggressive during the first days.
References: [1] BVerfG, Urteil des Zweiten Senats vom 24. Juli 2018 We were told to give him psychiatric attention and prescribed nico-
- 2 BvR 309/15 - Rn. (1–131), http://www.bverfg.de/e/rs20180724 tine patches and some anxiolytic treatment. Once he felt relieved
2bvr030915.html, 11.10.2018. [2] Martin V, Kuster W, Baur M, we provided him with information about the tobacco cessation
et al. Die Inzidenz von Zwangsmaßnahmen als Qualitätsindika- clinic with the aim of him stopping smoking after his discharge.
tor in psychiatrischen Kliniken. Probleme der Datenerfassung und Currently he is abstinent of nicotine.
-verarbeitung und erste Ergebnisse. Psychiat Prax 2007; 34:26–33. Conclusions.– Smoking tobacco habit is a very common addiction
Disclosure of interest.– The authors have not supplied a conflict of among all groups of age. Sudden tobacco cessation due to hos-
interest statement. pitalization can lead to aggressiveness, anxiety, mood disorders,
and other psychiatric disorders. An adequate and protocolized
approach is needed with this group of patients to improve the Denmark, Odense, Denmark; 6 Centre for Psychiatric Nursing and
general health outcome and to bring the best experience within Health Care Research, Region of Southern Denmark, Vejle, Denmark
the hospital. Interdisciplinary cooperation is needed to tackle more
efficiently those situations.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– Widowed people have a high risk of common
interest statement. mental disorders, however no summary estimates of the preva-
lences exist.
The aim of this study is to conduct a systematic review and meta-
E-PP0495 analysis of the prevalence of common mental disorders in widowed
Individual benzodiazepine exposure people in the community.
during early pregnancy and the risk of Methods.– MEDLINE, Embase and PsycInfo were searched (May
2017) for papers reporting on prevalence of common mental dis-
spontaneous abortion orders and widowhood. Eligible studies were included in random
A. Berard1* , O. Sheehy2 , J.P. Zhao2
1 effects meta-analyses of the prevalence of depression and anxi-
University of Montreal, CHU Sainte-Justine, Research Center,
ety disorders. Subgroup analyses were performed on method of
Montreal, Canada; 2 CHU Sainte-Justine, Research Center, Montreal,
assessment of depression and age and gender.
Canada
* Corresponding author. Results.– The literature search identified 12,982 titles of which 38
were eligible for meta-analysis. The pooled prevalence of depres-
Background and aims.– Benzodiazepines are frequently used during sion in studies using a screening scale was 40.69% (32.77%–48.62%)
pregnancy. We aimed to quantify the risk of spontaneous abor- (n = 26). For studies using full diagnostic criteria the pooled preva-
tion associated with prenatal benzodiazepine use as a class and for lence of depression was 19.21% (13.38%–25.04%) (n = 12). Subgroup
individual benzodiazepine. analyses of age (≥ or < 65) and gender did not show any differ-
Methods.– A nested case-control study was conducted within the ences regarding depression. Five studies reported the prevalence
Quebec Pregnancy Cohort, 1/1/1998 to 31/12/2015. Five controls of anxiety disorders. The pooled prevalence estimate was 26.91%
were matched to each case of spontaneous abortion. Benzodi- (8.09%–45.73%).
azepine exposure was defined by filled prescriptions and identified Conclusions.– Widowed people have a high prevalence of depres-
as (1) non-user, (2) used in the year before pregnancy, and sion and anxiety disorders. The high prevalence of depression
(3) used during pregnancy. Conditional generalized estimating was independent of age and gender. The study identifies a pop-
equation regressions were used to estimate odds ratios (OR) ulation group at high risk needing special attention in clinical
and 95% confidence intervals (CI) for the risk of spontaneous practice.
abortion. Disclosure of interest.– The authors have not supplied a conflict of
Results.– A total of 1,195 (3.92%) of the 30,470 pregnancies ending interest statement.
with a spontaneous abortion had at least one filled prescription for
benzodiazepine during pregnancy, as compared with 2,670 (1.77%)
E-PP0497
of the 151,264 matched controls. After adjusting for potential
confounders, early pregnancy benzodiazepine exposure was asso- The association of time since spousal
ciated with an increased risk of spontaneous abortion (aOR 1.57, loss and depression in widowhood: a
95%CI 1.43–1.73); but not pre-pregnancy exposure (aOR 0.95, 95%CI systematic review and meta-analysis
0.88–1.01). Early pregnancy exposure to alprazolam (aOR 1.39, C. Blanner Kristiansen1,2,3* , J.N. Kjær4 , P. Hjorth5,6 , K. Andersen2 ,
95%CI 1.10–1.77), clonazepam (aOR 1.34, 95%CI 1.17–1.54), flu- A.M. Prina3
razepam (aOR 2.04, 95%CI 1.22–3.42), lorazepam (aOR 1.61, 95%CI 1 Region of Southern Denmark, Psychiatric Department Odense,
1.41–1.84), oxazepam (aOR 1.42, 95%CI 1.13–1.79) and temazepam University Function, Odense C, Denmark; 2 University of Southern
(aOR 1.50, 95%CI 1.06–2.14) were associated with an increased risk Denmark, Department of Clinical Research, Odense, Denmark; 3
of spontaneous abortion. Institute of Psychiatry, Psychology & Neuroscience at King’s College
Conclusions.– Maternal exposure to alprazolam, clonazepam, flu- London, Department of Health Service and Population Research,
razepam, lorazepam, oxazepam and temazepam during early Social Epidemiology Research Group, London, United Kingdom; 4
pregnancy were associated with an increased risk of spontaneous Aarhus University Hospital Risskov, Psychiatric Research Academy,
abortion. Benzodiazepine exposure before pregnancy alone was Department of Affective Disorders, Risskov, Denmark; 5 Institute for
not increasing the risk of spontaneous abortions, suggesting that Regional Health, Region of Southern Denmark, Odense, Denmark; 6
findings cannot be explained by indication bias. Centre for Psychiatric Nursing and Health Care Research, Region of
Disclosure of interest.– The authors have not supplied a conflict of Southern Denmark, Vejle, Denmark
Background and aims.– Widowhood is associated with a high

E-PP0496 prevalence of depression. However, no summary estimates of the
Prevalence of common mental longitudinal association of the time since spousal loss and the
disorders in widowhood: a systematic prevalence of depression exist.
The aim of this study is to conduct a systematic review and meta-
review and meta-analysis analysis examining the association of the prevalence of depression
C. Blanner Kristiansen1,2,3* , J.N. Kjær4 , P. Hjorth5,6 , K. Andersen1,2 ,
and time since spousal loss in widowed people.
A.M. Prina3
1 Region of Southern Denmark, Psychiatric Department Odense, Methods.– The databases MEDLINE, Embase and PsycInfo were
searched (May 2017) for papers reporting on time since spousal loss
University Function, Odense C, Denmark; 2 University of Southern
in widowed people and the prevalence of common mental disor-
Denmark, Department of Clinical Research, Odense, Denmark; 3
ders. Random effects meta-analyses of the prevalence of depression
Institute of Psychiatry, Psychology & Neuroscience at King’s College
were conducted by intervals of time since spousal loss.
London, Department of Health Service and Population Research,
Results.– The literature search identified 12,982 studies of which
Social Epidemiology Research Group, London, United Kingdom; 4
14 were eligible for inclusion in the meta-analysis. The summary
Aarhus University Hospital, Psychiatric Research Academy,
estimates for the prevalence of depression in the intervals of time
Department of Affective Disorders, Risskov, Denmark; 5 Institute for
since spousal loss were: ≤1 month: 38.3% (21.9%–55.8%), >1 month
Regional Health, Region of Southern Denmark, Region of Southern
to 3 months: 26.8% (17.0%–37.7%), >6 months to 12 months: 19.4% E-PP0499

(15.2%–24.0%), >12 months to 18 months: 11.1% (5.3%–18.7%), >18 ”The mind lives on the heart“:
months to 24 months: 15.2% (12.3%–18.2%), >24 months to 60
prevalence of patients with mental
months: 10.5% (4.3%–18.5%).
Conclusions.– Widowhood is associated with a high prevalence of
diseases among an italian cardiac
depression and the study identifies a population group needing spe- arrest registry (Paviacare)
cial attention in daily clinical practice. The prevalence is highest in N. Brondino1* , R. Matteo1 , B. Enrico2 , S. Simone3 , P. Pierluigi1
1 University of Pavia, Brain and Behavioral Sciences, Pavia, Italy; 2
the first month of widowhood, however continues to be high at
least five years into widowhood. University of Pavia, School of Cardiovascular Disease, Pavia, Italy; 3
Disclosure of interest.– The authors have not supplied a conflict of IRCCS Policlinico San Matteo, Division of Cardiology, Pavia, Italy
interest statement.
Background and aims.– Psychiatric patients show consistently
E-PP0498 higher mortality rates compared to the general population, with
more than ten years of potential life lost. Several factors may
Sociodemographic characteristics and explain this shorter life expectancy and physical comorbidities may
clinical variables as predictors for held responsible of this mortality gap. Among physical conditions,
rehospitalization in psychiatric cardiac sudden death is considered one of the main causes of pre-
hospital mature mortality in psychiatric illnesses. The causes of the high
I. Lokmic-Pekic1 , L. Bradic2* , A. Hrnjica3 , R. Softic4 , S. Nejra3 , D. prevalence of cardiac sudden death in psychiatric patients may rely
Begic1 in high rate of unhealthy lifestyle habits as well as in cardiac toxicity
1 Psychiatric Hospital of Canton Sarajevo, Intensive Care Unit, produced by psychotropic medications.
Sarajevo, Bosnia, Herzegovina; 2 Psychiatric Hospital of Canton We aimed to evaluate the prevalence of psychiatric patients among
Sarajev, Men’s Psychatric Department, Sarajevo, Bosnia, a registry for cardiac arrest (PaviaCaRE) and to identify potential
Herzegovina; 3 Psychiatric hospital of Canton Sarajevo, Woman’s characteristics of this patient group.
Psychiatric Department, Sarajevo, Bosnia, Herzegovina; 4 Psychiatric Methods.– Out-of-hospital cardiac arrest (OHCA) medical records
hospital of Canton Sarajevo, Men’s Psychatric Department, Sarajevo, occurred in the Province of Pavia (in the North-West of Italy)
Bosnia, Herzegovina between October 2014 and March 2017 were retrospectively
* Corresponding author. reviewed.
Results.– 2085 OHCA occurred in the study period; 85 were
Background and aims.– Repeated hospital treatment is related with excluded beceause the name of the patients was unavailable.
many clinical variables and with sociodemographic characteristics. Among the 2000 identified patients, the prevalence of psychiatric
Rehospitalizations for psychiatric patients are an increasing health patients was 10.6%. Regarding the etiology of OHCA, 84.3% was clas-
care burden. Psychiatric readmissions have been studied at length. sified as medical (vs 93.1% in general population), 8.7% as traumatic
However, knowledge about how environmental and health system (vs 4.4% in general population) and 3.5% as drug overdose (vs 0.3%
characteristics affect readmission rates is scarce. in general population). Psychiatric patients having an OHCA were
Aim of this study was to determine whether sociodemographic mostly males (57%) and middle aged.
characteristic and clinical variables can be used as predictors for Conclusions.– Our data are in line with findings from the Danish
future hospital treatment. Cardiac Arrest Registry which observed similar rate of psychiatric
Methods.– The retrospective analysis included medical records of patients. Of note, possible suicide as main cause of death was low
70 patients (27 women and 43 men) admitted to the Psychiatric compared to previous studies.
hospital of Canton Sarajevo in 2016. Patients were divided into two Disclosure of interest.– The authors have not supplied a conflict of
groups (experimental n = 34, control n = 36). Control group included interest statement.
patients with one hospital treatment, while experimental included
patients with several hospitalizations in our hospital.
Results.– This study included 70 patient; 34 in experimental group E-PP0500
and 36 in control. Average age in control group is 54; in exper- Mental health, discrimination and
imental group 49,97 with no significant difference. Regarding
service use of the finnish roma
sex distribution, there were no statistically significant differ-
ences between groups. There was statistically significant difference population. first results of the finnish
regarding psychotic symptoms at admission; prevalence of symp- roma wellbeing study (ROOSA)
toms was much lower in control group (p = 0,0334). We found no A. Castaneda* , A. Weiste-Paakkanen, H. Kuusio
statistically significant difference between two groups analyzing National Institute for Health and Welfare, Inclusion and Equality
sociodemographic characteristics. Unit, Helsinki, Finland
Conclusions.– The implications of these results could have great
impact on future work of psychiatrist with inpatients. It is
Background and aims.– The National Policy on Roma has been
demonstrated that psychotic symptoms are predictors for rehos-
implemented in Finland since 2009 to advance the Finnish Roma
pitalization. Background of this hypothesis could be avoidance of
minority inclusion and equal treatment. The policy states that
proper use of recommended therapy, that leads to psychotic erup-
Roma wellbeing is promoted and social and health services are
tion and consequently admission to hospital.
targeted towards the Roma, however there has been a lack of
research data pointing the ethnic gaps in health and wellbeing.
interest statement.
The aim of the Finnish Roma Wellbeing Study was to investigate
the Finnish Roma minority health, wellbeing and usage of social
and health services in Finland, including various aspects of mental
health.
Methods.– The Finnish Roma Wellbeing Study was targeted to the
Finnish Roma minority population aged 18 or older (n = 330), gath-
ered in 2018 and including a health examination and an individual
structured face-to-face interview. Research assistants who were
Roma themselves introduced the study to Roma communities and E-PP0502

individuals and invited them to participate. Mental health was Disability benefits and mental health
assessed with eg. HSCL-25 and MHI-5.
in the UK 2010–2017
Results.– Mental health symptoms were more prevalent, especially
S. Dorrington1* , M. Henderson2 , S. Harvey3
among the women, in comparison to what has been observed in 1 KCL and RCPsych, Psych Med, London, United Kingdom; 2 Leeds and
the Finnish general population. Experiences of discrimination were
York NHS Trust Partnership, Occupational Mental Health, Leeds,
also highly prevalent.
United Kingdom; 3 Black Dog Institute, School of Psychiatry, Sydney,
Conclusions.– Data on ethnic minorities is needed in order to reduce
Australia
the ethnic gaps in health, including mental health, and to develop- * Corresponding author.
ment service systems to serve the whole population. In order to
conduct a survey among the Roma community, trust must be built, Background and aims.–
flexible survey protocol must be utilized and Roma research field Background.– There has been a large increase in the number of peo-
staff must be involved. ple receiving disability benefits for mental health problems. We do
Disclosure of interest.– The authors have not supplied a conflict of not know whether this is explained by an increase in mental health
interest statement. problems across the general population.
Aims.– To describe trends in mental illness and disability benefit in
the UK 2000–2017, to see whether the increase in people receiving
E-PP0501 disability benefits for mental health problems can be explained by
The occurrence of dementia in an increase in mental health problems in the general population.
alzheimer disease and vascular Methods.– Population level data from the UK Department of Work
dementia in the republic of belarus and Pensions (DWP) and the Adult Psychiatric Morbidity Survey
T. Dakukina1* , A. Startsev2 , T. Golubeva3 , E. Sheremet4 were analysed in stata 15.
1 Republican Scientific-Practical Center of Mental Health, Deputy Results.– There was an increase in disability benefit given for com-
Director for Research of the Republican Scientific and Practical Center mon mental disorders from 2000–2017. This was not explained
for Mental Health, Minsk, Belarus; 2 Republican Scientific-Practical by the slight increase in common mental disorders in the general
Center of Mental Health, Director of the Republican Scientific and population.
Practical Center for Mental Health, Minsk, Belarus; 3 Republican Conclusions.– The rise in employment and support allowance ben-
Scientific-Practical Center of Mental Health, Scientific Secretary of the efits given to patients with common mental disorders was not
Republican Scientific and Practical Center for Mental Health, Minsk, explained by changes in prevalence of common mental disorder
Belarus; 4 Republican Scientific-Practical Center of Mental Health, in the general population.
Psychiatrist-Narcologist of the Hospital of the Republican Scientific Disclosure of interest.– The authors have not supplied a conflict of
and Practical Center for Mental Health, Minsk, Belarus interest statement.
Background and aims.– The percentage of older people in Belarus in E-PP0503

increasing, resulting in growing number of reported cases of mental Recovery-café: a peer-run service for
diseases, in particular with dementias. people in a mental crisis
Methods.– The purpose of the study was to analyze the rates of G. Eikmeier1* , A. Lacroix1 , B. Kowski1 , C. Sternhagen2 , U. Peters3
dementias, including those of dementia in Alzheimer disease and 1 Klinikum Bremerhaven Reinkenheide gGmbH, Department of
vascular dementia, in the Republic of Belarus. National statistical Psychiatry, Psychotherapy and Psychosomatics, Bremerhaven,
data for 2017 were used to obtain absolute numbers of cases and Germany; 2 Verein für Neue Arbeit in Bremerhaven e.V., Soziale
to calculate the occurrence rates (per 100,000 people). Dienstleistungen im Verbund, Bremerhaven, Germany; 3 SPSD
Results.– By the end of 2017, 10,142 people in Belarus were regis- Bremerhaven, Bremerhaven, Germany
tered as having dementia and requiring regular supervision by the * Corresponding author.
doctor, including 1,609 people (15.9%) with dementia in Alzheimer
disease and 4,612 people (45.5%) with vascular dementia. The total Background and aims.– Peer-operated mental health services focus-
occurrence of dementia was 202.5 per 100,000 people, including ing on personal recovery have received increasing attention.
28.3 per 100,000 people for dementia in Alzheimer disease and 98.5 We studied whether a peer-run low-threshold service in the late
per 100,000 people for vascular dementia. The rate of hospitaliza- afternoon is accepted by people in a mental crisis, can be operated
tion with dementias was 4.6 per 10 thousand population, including by peers without assistance of other professionals, and become an
0.6 per 10 thousand for dementia in Alzheimer disease and 2.2 per alternative to an emergency department.
10 thousand for vascular dementia. Methods.– Since January 2017 the Department of Psychiatry at
Conclusions.– The above results demonstrate the prevalence of vas- Klinikum Bremerhaven runs a recovery-café (opening hours: Mon-
cular dementia over the dementia in Alzheimer disease in the day to Friday 6 p.m. to 10 p.m) in downtown Bremerhaven operated
overall pattern of dementias in population of Belarus. by peers with an EX-IN-training. Analysed were the questionnaires
The obtained data show the urgent need for improvement of diag- filled in by the guests, three focus-groups on the issue “Recovery-
nostic methods to differentiate between the dementia types and Café” and the use of the emergency department by people in a
prevent the cerebrovascular diseases. crisis.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Between January 2017 and June 2018 the recovery-café
interest statement. had 2294 visits by 188 guests (81 female, 101 male, 6 missing data,
age: 19 and 78 years) who came for different problems, some also
out of curiosity, boredom or loneliness. They appreciated the social
contacts, the conversation and the safe and calm atmosphere. Dur-
ing the second half of 2017 it became apparent that on the one
hand guests come to the recovery-café with an acute problem and
on the other hand a group considers the café as an alternative offer
in the evening or comes to prevent a mental worsening. Up to now
running the recovery-café had no significant effect on the use of
the emergency department, but seems to be an additional, useful of certain non-genetic pre- and perinatal risk factors might also be
service. implicated.
Conclusions.– A peer-operated service in the late evening is Methods.– We conducted a historical cohort study to examine the
accepted and mostly appreciated by people in a mental crisis. association between obstetric procedures (cesarean section [CS],
Disclosure of interest.– The authors have not supplied a conflict of assisted delivery, and induction by pitocin) with risk of ASD. The
interest statement. cohort consisted of the national birth and autism databases of
Norwegian’s National Health Insurance Registry (N = 2,234,392 live
births). We used logistic regression models to compute odds ratios
E-PP0504 (OR) and 95% confidence intervals (95%CI) for ASD for every obstet-
Undergraduate students’ anxiety and ric procedure vs. all births in which the specific procedure was
depression prevalence at the not applied. Data were stratified on sex and gestational age for all
procedures, and on type of surgery (elective vs. emergency) for CS.
university of patras, greece due to
Results.– We found a 67% increase in ASD risk among children born
academic and other stressors by CS compared to vaginal delivery (95%CI, 1.48–1.88; p < .001).
including gender inequality: a The association was independent of type of surgery and persisted
cross-sectional study after stratification by gestational age categories. An increased risk
E. Giourou1* , E. Giannopoulou2 , S. Alexopoulou2 , L. Karamani2 , K. for ASD was also observed in forceps-assisted deliveries, but was
Argyropoulos3 , P. Gourzis1 , E. Jelastopulu3 limited to male post-term newborns. No association was found
1 University of Patras, Psychiatry, Patras, Greece; 2 University of between vacuum extraction or pitocin induced labor and ASD.
Patras, Medical School, Patras, Greece; 3 University of Patras, Public Conclusions.– Both elective and emergency CS were found to be
Health, Patras, Greece associated with risk of ASD across gestational ages. This finding
* Corresponding author. is consistent with some of the previous studies and might help
identify newborns at risk for ASD, and might also have potential
Background and aims.– Admission to higher education, poses implications for risk reduction.
extreme stressors upon students prone to develop emotional and Disclosure of interest.– The authors have not supplied a conflict of
anxiety disorders. The aim of the present study was to estimate interest statement.
the prevalence of anxiety and depression in undergraduates of the
University of Patras, investigating the association of academic, psy-
chosocial and socio-demographic stressors. E-PP0506
Methods.– 2424 students were included. A self-administered online Models of the impact of living
questionnaire for the socio-demographic and academic character-
conditions and psychiatric care
istics and the Hospital and Anxiety Depression Scale (HADS) were
used for the assessment. All statistical data analyses were per- resources on the indicators of mental
formed using SPSS version 21.0 (IBM Corp, 2012). health among the population of the
Results.– High anxiety (57%) and depression (36%) frequencies were russian federation
reported. Mean HADS anxiety scores were 7.7 in males and 9.3 in V. Mitikhin1 , V. Golimbet2*
females, despite females’ overall better academic performances and 1 Mental Health Research Center, Department of Mental Health
following studies of their choice opposed to males. In univariate Support Systems, Moscow, Russia; 2 Mental Health Research Center,
analysis, females, lower academic performance, less communi- Clinical Genetics Laboratory, Moscow, Russia
cation or cooperation with fellow students and teachers, higher * Corresponding author.
competitiveness in the academic environment, lower quality of

university facilities as well as dismal future career outlook had Background and aims.–
higher scores for females compared to comparative males. Compar- Introduction.– Analytical models of the relationship between the
ing the results with a same study performed in 2012, the proportion mental health of the population and socio-economic factors, based
of students with anxiety and depression has nearly doubled (56.7% on data for Russia during the period 1992–2012, were presented in
vs. 34.2% and 36% vs. 18%, respectively). works [1–2].
Conclusions.– A substantial proportion of students at the University Aim.– This study aims to obtain quantitative assessments of the
of Patras suffer from anxiety and depression while females seem to effect of medico-demographic and socio-economic factors on the
be more affected on the stressors posed upon them possibly indi- key indicators of mental health of the population of the Russia for
cating a gender inequality related to the academic environment the period 1992–2016.
conditions, expectations imposed as well as the current socio- Methods.– To assess the significance of the relationship between the
economic structure in Greece. indicators of mental health and medico-demographic and socio-
Disclosure of interest.– The authors have not supplied a conflict of economic factors, correlation and regression analysis were used.
interest statement. Results.– At the population level, quantitative assessments have
been obtained of the impact of socio-economic and medico-
demographic factors on the dynamics of the main indicators
E-PP0505 (prevalence, incidence, suicide rate) of the mental health of the
Assisted delivery and cesarean section population of the Russia for the period 1992–2016. Robust mod-
els (R2 ranging from 0.95 to 0.99) were obtained of indicators of
and risk of autism spectrum disorder
prevalence for all diagnostic groups.
N. Goldental1* , Y. Sheffer2 , R. Gross1
1 Conclusions.– Models have been developed that link the main indi-
Chaim Sheba Medical Center, Division of Psychiatry, Ramat Gan,
cators of the mental health of the population to demographic and
Israel; 2 Sackler Faculty of Medicine, Department of Epidemiology, Tel
socio-economic factors; they have good predictive characteristics.
Aviv, Israel
* Corresponding author. References.–
[1] Mitikhina, I. A., Mitikhin, V. G., Tvorogova, N. A. et al. Effect of
Background and aims.– Although the dramatic rise in rates of autism social-economic factors on mental health indices in the population
spectrum disorder (ASD) could be attributed in part to changes in of the Russian Federation in 1992–2008: Epidemiological models.
ASD definition and increase in awareness, increase in prevalence S.S. Korsakov Journal of Neurology and Psychiatry. 2012; 112 (4);
4–10. (In Russ). [2] Mitikhina I. A., Mitikhin V. G., Iastrebov V. S.,
et al. Mental health in the Russian Federation in 1992–2010. S.S. E-PP0508

Korsakov Journal of Neurology and Psychiatry. 2013; 113 (9): 4–13. Primary and specialized somatic
(In Russ).
health care utilization prior to
interest statement.
cardiovascular death in individuals
with severe mental illness
I. Heiberg1* , B.K. Jacobsen1,2 , L. Balteskard1 , J.K. Bramness3,4 , Ø.
E-PP0507 Næss5,6 , E. Ystrom7,8,9 , T. Reichborn-Kjennerud5,7 , C.M.
Detection of cardiovascular disease Hultman10,11 , R. Nesvåg3,12 , A. Høye1,3,13
1 Northern Norway Regional Health Authority, Center for Clinical
prior to cardiovascular death in
Documentation and Evaluation, Tromsø, Norway; 2 UiT - The Arctic
individuals with severe mental illness University of Norway, Department of Community Medicine, Tromsø,
I. Heiberg1* , B.K. Jacobsen1,2 , L. Balteskard1 , J.G. Bramness3,4 , Ø. Norway; 3 UiT - The Arctic University of Norway, Department of
Næss5,6 , E. Ystrom7,8,9 , T. Reichborn-Kjennerud5,7 , C.M. Clinical Medicine, Tromsø, Norway; 4 Innlandet Hospital Trust,
Hultman10,11 , R. Nesvåg3,12 , A. Høye1,3,13 Norwegian National Advisory Unit on Concurrent Substance Abuse
1 Northern Norway Regional Health Authority, Center for Clinical
and Mental Health Disorders, Hamar, Norway; 5 University of Oslo,
Documentation and Evaluation, Tromsø, Norway; 2 UiT - The Arctic Institute of Clinical Medicine, Oslo, Norway; 6 University of Oslo,
University of Norway, Department of Community Medicine, Tromsø, Institute of Health and Society, Oslo, Norway; 7 Norwegian Institute
Norway; 3 UiT - The Arctic University of Norway, Department of of Public Health, Department of Mental Disorders, Oslo, Norway; 8
Clinical Medicine, Tromsø, Norway; 4 Innlandet Hospital Trust, University of Oslo, School of Pharmacy. PharmacoEpidemiology and
Norwegian National Advisory Unit on Concurrent Substance Abuse Drug Safety Research Group, Oslo, Norway; 9 University of Oslo,
and Mental Health Disorders, Hamar, Norway; 5 University of Oslo, Department of Psychology, Oslo, Norway; 10 Karolinska Institutet,
Institute of Clinical Medicine, Oslo, Norway; 6 University of Oslo, Department of Medical Epidemiology and Biostatistics, Stockholm,
Institute of Health and Society, Oslo, Norway; 7 Norwegian Institute Sweden; 11 Mt Sinai Hospital, Icahn School of Medicine, New York,
of Public Health, Department of Mental Disorders, Oslo, Norway; 8 USA; 12 Norwegian Medical Association, Department of Medicine,
University of Oslo, School of Pharmacy. PharmacoEpidemiology and Oslo, Norway; 13 University Hospital of North Norway, Division of
Drug Safety Research Group, Oslo, Norway; 9 University of Oslo, Mental Health and Substance Abuse, Tromsø, Norway
Department of Psychology, Oslo, Norway; 10 Karolinska Institutet, * Corresponding author.
Department of Medical Epidemiology and Biostatistics, Stockholm,
Sweden; 11 Mt Sinai Hospital, Icahn School of Medicine, New York, Background and aims.– Lower levels of prevention and treatment
USA; 12 Norwegian Medical Association, Department of Medicine, of cardiovascular disease (CVD) in individuals with schizophrenia
Oslo, Norway; 13 University Hospital of North Norway, Division of (SCZ) or bipolar disorder (BD) are documented, but less is known if
Mental Health and Substance Abuse, Tromsø, Norway this disparity persists in individuals close to cardiovascular death.
We examined whether SCZ and BD were associated with lower
likelihood of diagnostic testing and treatment for CVD prior to car-
Background and aims.– Premature death from cardiovascular dis- diovascular death.
ease (CVD) in individuals with schizophrenia (SCZ) or bipolar Methods.– A nationwide study of 72,451 cardiovascular deaths in
disorder (BD) is well documented, whereas the level and conse- the years 2011–2016, of whom 814 had a diagnosis of SCZ and 673
quences of unrecognized CVD in these individuals is less studied. a diagnosis of BD in primary or specialized health care. Logistic
We aimed to examine if individuals with SCZ or BD had equal regression was used to study the impact of SCZ and BD on uptake of
likelihood of having CVD diagnosed prior to cardiovascular death, cardiometabolic tests (i.e. ECG, echocardiography, measurement of
compared to individuals without SCZ or BD. blood pressure, cholesterol, glucose and HbA1c), and invasive car-
Methods.– A nationwide registry study of 72,451 cardiovascular diovascular procedures (i.e. revascularization, pacemaker implant
deaths in the years 2011–2016, of whom 814 had a SCZ diagnosis or peripheral vascular surgery) prior to cardiovascular death.
and 673 a BD diagnosis in primary or specialist health care. Multi- Results.– Preliminary results suggests that individuals with SCZ
variate logistic regression was applied to study the impact of SCZ were 26% less likely (adjusted OR 0.74; 95% CI 0.61–0.89) and
and BD on recognized CVD prior to death. individuals with BD 37% more likely (adjusted OR 1.37; 95% CI
Results.– Individuals with SCZ were 40% less likely (adjusted OR 1.06–1.77) to receive cardiometabolic tests, compared to individ-
0.60; 95% CI 0.51–0.72), women with BD were 29% less likely uals without SCZ or BD. Among individuals with diagnosed CVD
(adjusted OR 0.71; CI 0.54–0.93) and men with BD were equally prior to death, individuals with SCZ or BD were 44% (adjusted OR
likely (adjusted OR 1.11, 95% CI 0.79–1.55) to be diagnosed with 0.56; 95% CI 0.43–0.72) and 35% less likely (adjusted OR 0.65; 95%
CVD prior to cardiovascular death, compared to individuals with- CI 0.50–0.84) to undergo invasive cardiovascular treatment, com-
out SCZ or BD. Almost all (98%) individuals with SCZ or BD and pared to individuals without SCZ or BD.
unrecognized CVD had visited primary or specialized somatic care Conclusions.– Patients with schizophrenia and bipolar disorder
prior to death, compared to 88% among the other individuals who receive less invasive treatment for CVD prior to cardiovascular
died of CVD. death, and patients with schizophrenia less diagnostic testing.
Conclusions.– Individuals with SCZ and women with BD are at Stronger effort to detect and treat CVD in these patients is needed.
higher risk for death from unrecognized CVD, even though most Disclosure of interest.– The authors have not supplied a conflict of
utilize primary and/or somatic health care prior to death. Increased interest statement.
attention on recognition, prevention and treatment of CVD risk fac-
tors in individuals with severe mental illness from young age is
needed. E-PP0509
Prevalence of dsm-iv major mental
interest statement.
psychiatric disorders among north
korean defectors in South Korea
J.P. Hong* , K.E. Lee
Samsung Medical Center, Psychiatry, Seoul, Republic of Korea
Background and aims.– The aim of this study was to estimate the
prevalence of the major psychiatric disorders among North Korean
defectors (NKD) who has settled in South Korea.
Methods.– The study population was consisted of 294 North Korean
defectors, aged 18 to 64 years within 3 years of settling in South
Korea. Between June 1st, 2016 and October 31st, 2016, face to face
interviews were conducted using the North Korean version of the
WHO-Composite International Diagnostic Interview (NK-CIDI) to
diagnose DSM-IV psychiatric disorders.
Results.– The lifetime prevalence of any DSM-IV psychiatric disor-
ders were 62.1% in NKD and 26.6% in general Korean population.
Those specific disorders in NKD and general South Korean popula-
tion were as follows: 25.1% and 5.1% for major depressive disorder
(MDD), 22.4% and 1.4% for post-traumatic stress disorder (PTSD),
6.3% and 5.0% for nicotine dependence, 17.9% and 13.6% for alco-
hol use disorder. The incidence of every single psychiatric disorder
occurred differently in each country. For instance, the generalized
anxiety disorder, specific phobia, and alcohol use disorder occurred
more frequently in North Korea whereas PTSD were more prevalent
in third countries. However, MDD occurred evenly in North Korea,
South Korea and third country. Figure 1. Influence factors for annual hospital admission days–a:
Conclusions.– The prevalence of psychiatric disorders among NKD dependant variable: annual hospital days during ICM–b: indepen-
were quite higher than the general population of South Korea. Ide- dant variables: (Constant), patient lives alone, patient lives alone,
ally, mental health support would be the priority step of a successful annual involuntary hospital stays before ICM, annual involun-
adaptation for those defectors as well as refuges for a new settle- tary hospital stays before ICM, F6x diagnosis, F2x/F31.x, diagnosis,
ment and their subsequent quality of life. annual involuntary hospital stays before ICM.
Disclosure of interest.– The authors have not supplied a conflict of Conclusions.– The results show the effectiveness of ICM in reducing
interest statement. hospital days, but can only partially explain which factors influence
these reduction.
E-PP0510
interest statement.
Predictors for the duration of
inpatient hospital stays in intensive
case management in eastern lower
E-Poster Presentation: Epidemiology and Social
Austria?
W. Hrubos1* , N. Brandstetter2 ,
E. Gundendorfer2 , M. Jirgal2 ,
M.
Psychiatry/Mental Health Care
Ramirez-Gaite2
1 Klinik Pirawarth, Psychosomatic Medicine, Bad Pirawarth, Austria;
2 PSZ GmbH, Psychosocial Services, Stockerau, Austria E-PP0511
Use of direct coercive measures on the
Background and aims.– Since 2012, as a result of the Lower Austrian
example of psychiatric hospital in
psychiatry plan, the Psychosoziale Zentren GmbH (PSZ) worked on wrocław (POLAND)
the implementation of Intensive Case Management (ICM) in the M. Jakubczyk
eastern part of Lower Austria. The aim of the present study is to Wroclaw Medical University, Department of Psychiatry, Wroclaw,
examine whether there are any indications in the ICM in Lower Poland
Austria about the personal or treatment characteristics associated
with inpatient admissions.
Background and aims.– The prospective study was carried out in
Methods.– Statistical evaluation was performed with SPSS. Descrip-
the psychiatric hospital in Wrocław because of the highest rates of
tive analyzes, 2-sided T-tests and a multivariate linear regression
coercion recorded in the Lower Silesian Voivodship.
analysis were performed.
Aims of the study are to assess: (1) the frequency of direct coercive
Results.– 240 patients, 162 women (67.5%) and 78 men (32.5%)
measures in the hospital, (2) the main factors predisposing to direct
were recorded for this study. The results showed that the num-
coercion.
ber of annual hospital days during ICM decreased significantly by
Methods.– Hospitalised patients and situations of use of direct coer-
an average of 6.3 days (SD = 31.3; p = 0.002) from 11.3 before ICM
cion were assessed with the help of selected tools (MPCS, BPRS,
(SD = 31.3) to 5.0 during ICM (SD = 14.5).
GAF, CAT, MANSA) and additional questionnaires on basic data. The
The linear regression model (figure 1), used the variables of inpa-
study included patients who during their stay felt a sense of coer-
tient days in the previous year before ICM, employment, age,
cion or were hospitalised without consent or were coerced during
psychiatric diagnosis of a psychotic illness or a personality disorder,
their hospitalisation. 346 patients were enrolled in the study, of
current housing status and number of annual involuntary hospital
which 237 were interviewed in person.
admissions, that explained 22%. (R2 = 0.22, p = 000) of the variance
Results.– The rate of use of direct coercion reached a value of almost
of the number of annual inpatient days during ICM. Only inpatient
21% in relation to all patients. Mechanical restraint dominated and
days in the year before ICM and involuntary inpatient stays during
accounted for 80% of all episodes.
ICM reached significant coefficients with p = 000 (0.17 and 8, 87).
Admissions under Articles 22.2a and 24.1 of Mental Health Act
were associated with a higher risk of direct coercion, and this
risk decreases significantly in the case of admissions under Art-
cle 29. The use of direct coercion during earlier hospitalisations
and multiple previous hospitalisations without consent, severity
of symptoms examined using the BPRS, lower score in functioning Psychotherapie, Hanover, Germany; 6 KRH Psychiatrie Wunstorf,
measured using the GAF are associated with an increased risk of Allgemeinpsychiatrie und Psychotherapie, Wunstorf, Germany
direct coercion. * Corresponding author.
Conclusions.– The psychiatric hospital in Wroclaw is characterised

by relatively higher rates of direct coercion in comparison to Background and aims.– In 2015, around 70,000 people with chronic
national surveys. There are risk factors which should be taken into psychiatric disorders in Germany used the services of inpatient
consideration in case of admission to psychiatric hospital. reintegration support within the social welfare system. Against the
Disclosure of interest.– The authors have not supplied a conflict of background of current political demands for a higher degree of
interest statement. empowerment and participation, the services of inpatient reinte-
gration support are becoming increasingly controversial. In fact, it is
currently evident that many people remain in the residential rein-
E-PP0512 tegration institutions, despite their desire to live independently.
World mental health survey Turkey: In addition to aspects of disorder severity and a lack of affordable
housing, personal considerations and capabilities play a crucial role.
methods and preliminary results
Methods.– The study examines residential patients who moved
C. Kilic1* , B. Üstün2 , Ö. Ulug3
1 from a reintegration assistance institution in Hanover into their
Hacettepe University- Faculty of Medicine, Psychiatry, Ankara,
own homes. A longitudinal and outreaching study design is used.
Turkey; 2 Koc University, Psychiatry, Istanbul, Turkey; 3 Arel
The participants are interviewed by qualitative guideline-based
University, Psychology, Istanbul, Turkey
* Corresponding author. interviews first in the institution before they moved out and second
in their independent livings six weeks later.
Background and aims.– Psychiatric epidemiological surveys reveal The interviews are analyzed following qualitative content analysis
high rates of mental disorders worldwide. The World Mental Health according to Mayring with regard to these key questions:
Surveys (WMH-S) were conducted on more than 150.000 people in What are reasons for and against leaving the residential institution?
27 countries. The first national-scale epidemiologic study (Mental How do they reflect their decisions six weeks after move out? What
Health Profile of Turkey) was done 20 years ago (Kilic 1998). In kind of support did they experience and what obstacles did they
that study, 7500 people were interviewed using Composite Inter- face?
national Diagnostic Interview (CIDI 1.0). A new survey is timely, Results.– Reasons for leaving the residential institution as well as
since no national-scale studies were conducted in past 20 years; individual, social, institutional and environmental resources and
Turkey’s population has increased from 60 million to 80 million; obstacles will be presented.
the proportion of people living in cities has increased from 60% to Conclusions.– The results provide an insight into difficulties and
over 92%; major changes were implemented in the healthcare sys- needs for support in order to realize a self-determined life in
tem; and finally, wars and armed conflicts and massive migration an independent living. Recommendations for concrete changes to
are widespread in the region. the existing institutionalized support system in Germany will be
Methods.– We are presenting the preparation phase and pre- derived.
liminary results of the Turkish World Mental Health Survey, a Disclosure of interest.– The authors have not supplied a conflict of
population-based epidemiological survey. The study will be rep- interest statement.
resentative of all Turkish citizens over the age of 18. It will use a
stratified, multi-stage, probability proportionate to size sample of
Turkish citizens living in 12 economic areas. Total targeted sample E-PP0514
will be 7.000. 100 trained interviewers will conduct face-to-face Exploring the link between stigma
interviews, using tablets, equipped with the CIDI-5, which will elicit and social representations among
DSM-5 diagnoses of common mental disorders. people with and without
Results.– The CIDI-5 has been translated into Turkish. We have also
schizophrenia in the French context
extensively pre-tested the translated CIDI-5 using a series of cog-
D. Lampropoulos1* , F. David2 , A. Thémis1
nitive interviews. The data collection is underway. 1 Aix-Marseille University, Laboratoire de Psychologie Sociale EA849,
Conclusions.– The preliminary results showing the current and
Aix-en-Provence, France; 2 Univ. Bourgogne Franche-Comté,
one-year prevalences of common mental disorders, and basic risk
Laboratoire de psychologie EA3188, Besançon, France
factors (such as gender, age, education) will be presented. * Corresponding author.
interest statement. Background and aims.– Culturally shaped negative representa-
tions lead to discrimination and self-stigma of people with
schizophrenia. In France, there are few studies on representations
E-PP0513 of schizophrenia. In this study, we explored the representations
Should I stay or should I go. . . that individuals associate with this mental disorder in the French
personal considerations and context, as well as the relationships between their own representa-
opportunities of people using tions and the representations they attribute to other French people.
Methods.– Data were collected by questionnaire from individuals
inpatient reintegration support to
in the general population (N = 98) and those with schizophre-
move out into independent living nia (N = 59). Using a verbal association technique, participants
J. Krieger1* , K. Friedrich1 , V. Rößner-Ruff1 , F. Schottky1 , M. produced five words spontaneously based on the inductor word
Ziegenbein2 , H. Grimmelmann-Heimburg3 , M.L. Dierks4 , F. “schizophrenia”. The instruction invited them to respond on their
Wedegärtner5 , I.T. Graef-Calliess6 own behalf, but also “as the French would in general”. Prototypical
1 Klinikum Wahrendorff, Forschung & Entwicklung, Hanover,
and similarity analyses were carried out.
Germany; 2 Klinikum Wahrendorff, Allgemeinpsychiatrie, Hanover, Results.– Results showed that the representations of participants
Germany; 3 Klinikum Wahrendorff, Geschäftsführung, Hanover, from the general population were associated with a vocabulary rel-
Germany; 4 MH Hannover, Institut für Epidemiologie, Sozialmedizin ative to schizophrenia as an illness and further with stigmatizing
und Gesundheitssystemforschung, Hanover, Germany; 5 MH stereotypes, such as madness, dangerousness and split personal-
Hannover, Klinik für Psychiatrie, Sozialpsychiatrie und ity when they expressed themselves on their own behalf. They
also drew on ideas of psychopathy and confinement when they
imagined how French people in general express themselves on the Methods.– The participants were undergraduates from department
subject of schizophrenia. Participants with schizophrenia who had of medicine and department of public health among 11 universi-
a clear view of the general population’s stereotypes also mostly ties in Taiwan. The development of the Mental Health Literacy Scale
referred to negative experiences and emotions such as loneliness, was done over three key stages: (1) measure development based on
suffering and fear. the latest definition of MHL, a narrative literature review, and focus
Conclusions.– These findings underline the value of considering the group interviews including professionals within the healthcare dis-
representations associated with schizophrenia in designing aware- cipline to establish content validity, (2) pilot testing (n = 32), and
ness campaigns for the general population, but also in caring for (3) scale construction, item reduction through item analysis and
people with schizophrenia who suffer from stigmatization. factor analysis, and assessment of internal consistency, convergent
Disclosure of interest.– The authors have not supplied a conflict of validity, concurrent validity and known group validity (n = 1294).
interest statement. Results.– Thirty-nine items with five factors were generated: pro-
motion of positive mental health, recognition of mental illness,
mental illness stigma, help-seeking efficacy, and help-seeking
E-PP0515 belief. Good internal consistency reliability was obtained (˛ = 0.84).
Burn injuries and post traumatic Higher MHL was associated with lower social distance and greater
stress disorder in Korea mental health, respectively. Participants having familiarity with
K. Lee mental illness had higher MHL than their counterparts.
CHA University, Bundang CHA medical center, Psychiatry, Seongnam, Conclusions.– A valid and reliable five-dimensional instrument
Republic of Korea measuring levels of MHL was developed. Our findings have the
potential to complement and expand current measures of MHL.
Background and aims.– The objective of this study is to broaden This measure can be used in assessing levels of MHL and in deter-
our understanding of psychiatric disorders due to work-related mining the impact of interventions to improve MHL in healthcare
burn injury compensated by the Industrial Accident Compensa- students and professionals.
tion Insurance operated by the Korea Workers’ Compensation and Disclosure of interest.– The authors have not supplied a conflict of
Welfare Service interest statement.
Methods.– Using the KCOMWEL electronic database, we collected
data on psychiatric disorders due to work-related burn injury based
on workers’ compensation records from 2005 to 2014 and analyzed E-PP0517
the characteristics of the claims. “The boomerang” project.
Results.– The average number of claims per year for post-traumatic rehospitalization patterns as potential
stress disorder was 67 and the approval rate from 2005 to 2014 was
targets for post hospitalization
53.6%. Regarding occupation, 63 workers were elementary work-
ers involved in the performance of simple and routine tasks which intervention procedures aiming for
may require the use of hand-held tools and considerable physical prolongation of outpatient periods
effort and 59 were electrical and electronic equipment fitters and P. Marcinowicz* , M. Wiedlocha wiedłocha,
˛ M. Janoska-Jazdzik, A.
repairers. Acute stress disorder, non-organic insomnia, and sexual Mosiolek, A. Szulc
dysfunction were the most commonly approved psychiatric disor- Clinic of Psychiatry, Department of Health Sciences, Medical
ders associated with work-related burn injury, followed by mixed University of Warsaw, Pruszkow, Poland
anxiety-depressive disorder.
Conclusions.– We analyzed the characteristics of the psychiatric
disorders due to work-related burn injury for which compensa- Background and aims.– Polish psychiatry is currently undergo-
tion was received from 2005 to 2014 according to the approved ing transition and the Boomerang project aims to develop a new
results. To gain a long-term understanding of the management patient-oriented system of care and ameliorate very high readmis-
of workers’ compensation status for psychiatric disorders due to sion rates (38% among 1018 patients in 04.2016–04.2018 period) in
work-related burn injuries, we should gather accurate informa- Mazovian Specialized Health Centre in Pruszków. Current research
tion on the risk factors involved in order to achieve the needed is a holistic summary of the “Interview and Case Research” phase
systematic improvements. of the project.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Medical records of “boomerang” patients were analysed
interest statement. for factors contributing to readmissions. 41 heavy psychiatric care
users currently hospitalized were interviewed for subjective causes
of readmission. Gathered data was analysed and synthetized into
E-PP0516 readmission patterns.
Results.– Pattern 1. Refers to addicted patients and is associated
Development and psychometric
with their lack of capacity to follow abstinence and post-discharge
evaluation of the new scale-based treatment recommendations. Pattern 2. The second pattern is
measure of mental health literacy for seemingly similar to the first one, although the causes underly-
healthcare students and professionals ing are different. These patients abuse psychoactive substances to
Y.J. Lien1* , H.J. Chao1 , I.C. Tsai1 , H.S. Lin1 , Y.C. Kao2 ameliorate their primary disorders’ symptoms. Frequent intoxica-
1 National Taiwan Normal University, Department of Health tions lead inevitably to exacerbations. Pattern 3. These patients
Promotion and Health Education, Taipei, Taiwan R.O.C.; 2 Tri-Service are poorly functioning and experience suicidal thoughts associated
General Hospital, Department of Psychiatry, Taipei, Taiwan R.O.C. with social adaptive difficulties, often complicated by personal-
* Corresponding author. ity disorders. Pattern 4. This pattern is associated with natural
unfavourable course of psychiatric illness, lack of compliance, treat-
Background and aims.– Informed by previous definitions of mental ment resistance or stressing life events.
health literacy (MHL), MHL is an evolving construct with distinct Conclusions.– Our research has yielded a distinction of 4 patterns.
components. There are currently no published scales to assess MHL The next phase of the project will consist of interdisciplinary con-
of healthcare students and professionals. This study aims to develop sultations and development of protocols that could be applied
a new scale-based measure of MHL, which assesses multiple com- by a “Rehospitalization Prevention Team” during inpatient and
ponents of MHL and its psychometric properties. post-discharge period. In strict collaboration with environmental
psychiatry this team could have a decentralized and personalised The authors aimed to understand possible differences in socio-
impact on the readmission rate. demographical and access to healthcare facilities between patients
Disclosure of interest.– The authors have not supplied a conflict of involuntarily admitted (compared to the voluntary ones).
interest statement. Methods.– Selection of patients admitted to the acute psychiatric
wards of Centro Hospitalar Psiquiátrico de Lisboa, in 2017 (570
patients, 51% male, 31% involuntary).
E-PP0518 From the patients’ files, the following variables were collected: age,
Winter is coming - migration among gender, diagnosis (according to the International Classification of
Psychiatric trainees in the North Diseases, tenth edition) and postal code of residency.
T. Mogren1* , M. Aztoles2,3 , J. Nørgaard Kjaer4 , J. Kaaja5 , M. Pinto da Merging of the postal code with the census data available
Costa6,7,8 (2011) at the subsection level, with collection of respective socio-
1 Karolinska Huddinge University Hospital, Department of Psychiatry, demographic variables (population and building density, patients
Stockholm, Sweden; 2 Aarhus University Hospital, Department of benefiting social pension, number of school years), as well as dis-
Psychiatry, Aarhus, Denmark; 3 Semmelweis University-, School of tance to the Psychiatric ward, Emergency services and General
PHD Studies, Budapest, Hungary; 4 Aarhus University Hospital, practitioner.
Psychiatric Research Academy, Department of Affective Disorders, Statistics were performed for the different variables, and spatial
Aarhus, Denmark; 5 University of Tampere, Psychiatry, Tampere, autocorrelation was measured using join counting statistics
Finland; 6 Hospital de Magalhaes, Lemos, Porto, Portugal; 7 Unit for Results.– Statistic significance towards involuntary admissions was
Social and Community Psychiatry WHO Collaborating Centre for found only regarding diagnosis (more Schizophrenic and affective
Mental Health Services Development, Queen Mary University of disorders), age (these patients were4 years younger, p = 0.007), and
London, London, United Kingdom; 8 Institute of Biomedical Sciences lower building density (p = 0.032). No other differences were iden-
Abel Salazar ICBAS, University of Porto, Porto, Portugal tified (involuntary admitted patients live closer to the healthcare
* Corresponding author. facilities). No cluster of patients were identified.
Conclusions.– In our sample, clinical symptoms of the patients seem
Background and aims.– Migration of medical professionals has a to be the main reason patients are admitted involuntarily, not socio-
global impact on healthcare and services. Although in the Scandi- demographical factors or distance to medical care.
navian countries there is a shortage of psychiatrists, still workforce Disclosure of interest.– The authors have not supplied a conflict of
migration is poorly understood. interest statement.
This study aimed to determine, within the Scandinavian countries,
the proportion of psychiatric trainees that have already moved
country, the reasons for psychiatric trainees to stay and leave the E-PP0520
country, and the influence of previous short-term mobility experi- Alcohol psychoses and suicides in
ences on the attitude towards migration. russia, ukraine and belarus: a
Methods.– In a multicentre, cross-sectional study (EFPT Brain Drain
comparative analysis
study), data were collected in three of the Scandinavian countries,
Y. Razvodovsky1 , S. Igumnov2
Denmark, Finland and Sweden. 1 Grodno Medical University, Central Research Laboratory, Grodno,
Results.– In Denmark and Finland few of the respondents were from
Belarus; 2 Institute of Psychology- Belarusian State University named
another country compared to more than a third in the Swedish sam-
after m.Tank, Clinical Psychology, Minsk, Belarus
ple. Half of the trainees in the Swedish and the Danish sample had * Corresponding author.
at least one experience of short time mobility while about a third
of the Finnish trainees had the same experience. The main reasons Background and aims.– The Slavic countries of the former Soviet
to leave the country in Sweden were academic, work, and financial, Union (fSU) Russia, Belarus and Ukraine retain one of the high-
whereas in Denmark were personal and academic reasons, and in est suicide rates in the world, despite a gradual decline over the
Finland academic reasons. past decade. The present study aims to analyze whether popula-
Conclusions.– Experience of migration differs in the Scandina- tion drinking is able to explain the dramatic fluctuations in suicide
vian countries in this study. Compared to Finland and Denmark, mortality in Russia, Belarus and Ukraine from the late Soviet to
more trainees from other countries have migrated to Sweden. In post-Soviet period.
Denmark and Sweden more trainees have short term mobility Methods.– Trends in suicide rates and alcohol psychoses rates from
experience. 1980 to 2010 in Russia, Belarus and Ukraine were analyzed employ-
Disclosure of interest.– The authors have not supplied a conflict of ing a Spearman’s rank-order correlation analysis.
interest statement. Results.– The estimates based on the Soviet data (from 1980 to 1991)
suggest a strong association between alcohol psychoses and sui-
cide rates in Russia (r = 0.85; p < 0.000), Ukraine (r = 0.80; p < 0.001)
E-PP0519 and Belarus (r = 0.84; p < 0.000). At the same time, the relationship
Are there socio-demographical between alcohol psychoses and suicide rates in the post-Soviet
differences regarding acute period (from 1992 to 2010) was positive only in Belarus (r = 0.85;
Psychiatric involuntary admissions? p < 0.000).
M. Nascimento* , B. Lourenço, I. Coelho, J. Aguiar, M. Lázaro, M. Conclusions.– The findings from present study suggest that the sui-
SIlva, M. Mónica, C. Pereira, I. Caldas, F. Gomes, S. Garcia, S. cide mortality fluctuations in Russia, Belarus and Ukraine in the
Nascimento, G. Pereira, V. Nogueira, P. Costa, A. Nobre Soviet period were attributable to alcohol. Alternatively, a complex
Centro Hospitalar Psiquiátrico de Lisboa, Clínic 5, Lisbon, Portugal interplay between alcohol and psychosocial distress can explain the
* Corresponding author. fluctuations in the suicide mortality observed in Russia, Belarus and
Ukraine in the Soviet period.
Background and aims.– Involuntary admissions are used as a last Disclosure of interest.– The authors have not supplied a conflict of
resort process regarding patient care, usually to patients with interest statement.
severe mental disorders with lack of insight towards their treat-
ment and imposing risk to themselves and/or others. Other factors,
besides clinical ones, can be relevant to their development.
E-PP0521 Results.– Preliminary results indicate that the secrecy about men-
Is discrimination towards patients tal illness correlates positively with perceived stigma, anticipated
with severe mental disorders still discrimination, self-stigma and loneliness, and negatively with
stigma resistance and the extent of social network. No significant
present? associations were found between secrecy and experienced stigma,
M. Savorani, G. Sampogna* , G. Borriello, B. Pocai, C. Palummo, V.
perceived available social support, self-esteem, self-efficacy, sense
Giallonardo, M. Luciano, V. Del Vecchio, A. Fiorillo
of coherence, overall psychopathology, depression and psychoso-
University of Campania “Luigi Vanvitelli”, Department of Psychiatry,
cial functioning.
Naples, Italy
Conclusions.– The results show a complex pattern of relationships
between secrecy about mental illness and psychosocial variables,
Background and aims.– whereas no associations with clinical indicators of the severity of
Introduction.– Experiences of discrimination are a relevant obsta- the disease have been demonstrated. Therapeutic interventions
cle in the life of persons with severe mental disorders, who are designed to assist people with psychotic disorders in their deci-
often discriminated also by relatives, friends, employers, mental sions to disclose their mental condition should take into account
health professionals and by themselves. There is the need to better the identified correlates of secrecy.
understand the most impacted areas in order to develop appropri- Disclosure of interest.– The authors have not supplied a conflict of
ate interventions. In this study, we aim to describe the experience of interest statement.
discrimination and the levels of self-stigma in a sample of patients
with severe mental disorders.
E-PP0523
Methods.– Patients attending the Outpatient Unit of the Depart-
ment of Psychiatry, University of Campania “L. Vanvitelli”, Naples, Association of cognitive functions and
in the period January–June 2018, were invited to participate in the covert brain ischemia – first results of
study. Validated questionnaires have been used to assess socio- the pure-mind Poland Cohort Study
demographic data, depressive symptoms, hopelessness, suicidal D. Szcześniak1* , J. Rymaszewska1 , A. Zimny2 , M. Sasiadek
˛ 2 , K.
ideation, stigma consciousness and experience of discrimination. Połtyn-Zaradna3 , K. Zatońska3 , T. Zatoński4 , A. Szuba5
Results.– Fifty patients were recruited, mainly female (54%), with a 1 Wroclaw Medical University, Department of Psychiatry, Wroclaw,
mean age of 46 (±15.1) years. Most frequent diagnoses were major Poland; 2 Wroclaw Medical University, Department of Radiology,
depression (42%) and bipolar disorder (20%). Patients experienced Wroclaw, Poland; 3 Wroclaw Medical University, Department of
discrimination in several areas, such as friendship (42%), work- Social Medicine, Wroclaw, Poland; 4 Wroclaw Medical University,
place (40%) and intimate relationships (38%). Moreover, patients Department and Clinic of Otolaryngology, Wroclaw, Poland; 5
had disclosed their mental health problems to family members Wroclaw Medical University, Department of Angiology, Wroclaw,
(90%) or friends (64%) only, but they felt not comfortable to talk Poland
about it (66%). Nevertheless, avoidance of social situations has been * Corresponding author.
reported only by 16% of patients, and more than 70% of them was
critical about most common prejudices and stereotypes. Background and aims.– The events of covered cerebral ischemia
Conclusions.– Discrimination toward persons with severe mental have been considered relevant causes shaping future cognitive
disorders is still present and influences mainly personal and social impairments such as Alzheimer’s disease. The aim of the study is
functioning areas. There is the need to promote interventions aim- to analyse the relationship between the history of cerebrovascular
ing to improve social inclusion of these patients. events and psychological factors including cognitive functions in
Disclosure of interest.– The authors have not supplied a conflict of the Polish cohort of the PURE-mind (Prospective Urban and Rural
interest statement. Epidemiological) study.
Methods.– The study group consisted of 872 subjects (mean age:
61.8 yrs range: 39–81 yrs, F/M: 549/323). All participants were
E-PP0522 assessed using international PURE-mind protocols including life-
Correlates of secrecy about mental style questionnaires, laboratory blood tests and neuropsychological
assessment measured with Montreal Cognitive Assessment (MoCA
illness among people diagnosed with
mean score: 25.8), TMT test, Digit Symbol Substitution, followed by
psychotic disorders structural brain MRI.
J. Sonik* , P. Świtaj Results.– Previous studies in older populations have reported a
Institute of Psychiatry and Neurology, I Department of Psychiatry, significant and consistent cross-sectional association between cog-
Warsaw, Poland nitive impairment and the presence of covert infarcts. Results from
present study covered the first detailed analysis and will expand the
knowledge of the clinical consequence of covert ischemia also in
Background and aims.– Mental disorders, especially psychosis, are
middle-aged population, when the disease process starts. Detailed
strongly stigmatized in the society. Psychiatric patients use various
assessment of cognitive state will be correlated with imaging find-
coping strategies with which they try to counteract the damaging
ings.
influence of the stigma. One of the most commonly used strate-
Conclusions.– The results of the study will be the milestone in iden-
gies is hiding the mental illness. However, there are indications
tifying high-risk groups of dementia development in Polish society.
that this strategy is associated with high psychological and inter-
personal costs for an individual. Unfortunately, relatively little is
interest statement.
known about which factors are related to greater secrecy about
mental health problems.
The current study seeks to explore the correlates of secrecy about
one’s mental illness.
Methods.– A total of 100 people diagnosed with psychotic disor-
ders have been recruited. Participants have been examined using an
extensive battery of questionnaires assessing the tendency to con-
ceal mental illness and various socio-demographic, psychosocial
and clinical variables.
E-PP0524 CKD were less likely to receive dialysis (p = 0.06) or kidney trans-
Epidemiological situation of anorexia plantation (p < 0.0001) than patients without schizophrenia.
nervosa in under 20 years old females Conclusions.– Patients with schizophrenia are more likely to have
comorbid CKD, compared to healthy controls. Nonetheless, they
in Russia are less likely to receive appropriate medical treatment including
E. Tiuliandina
dialysis and kidney transplantation. As CKD affects survival, quality
I.M. Sechenov First Moscow State Medical University, Public Health
of life, and medical and familial burden, additional thought should
and Health Care Organization Department, Moscow, Russia
be given to detection of CKD among schizophrenia patients.
Background and aims.– To find out actual epidemiological data of Disclosure of interest.– The authors have not supplied a conflict of
anorexia nervosa in under 20 years old females in Russia. interest statement.
Methods.– Epidemiological data of females under 20 years old from
1990 to 2016 from The Institute for Health Metrics and Evaluation
E-PP0526
(IHME) base has been analyzed. We used such parameters as inci-
dence, deaths, years lived with disability (YLDs), disability-adjusted End of life care and place of death in
life years (DALYs) in women patients, who live in Russia. patients with serious mental disorder:
Results.– In Russia in 1990 there were 28.11 new cases of anorexia results from routinely collected data
nervosa per 100,000; in 2002 - 33.04 per 100,000; in 2016 - 26.75 in South London
cases per 100,000. The number of deaths became widespread: R. Wilson1* , F. Gaughran2 , T. Whitburn3 , I.J. Higginson1 , W. Gao1
in 1990 0.00057 deaths per 100,000 were registered; in 2016 it 1 King’s College London, Cicely Saunders Institute, London, United
became 0.0055 deaths per 100,000. The parameter Years Lived with Kingdom; 2 King’s College London, Institute of Psychiatry, Psychology
Disability (YLDs) stays at the same level as in 1990: in 1990 the rate & Neuroscience, London, United Kingdom; 3 Barts Health Trust,
was 11.73 YLDs per 100,000; in 2003 - 14.37 YLDs per 100,00; in Macmillan Palliative Care Team, London, United Kingdom
2016 - 11.22 YLDs per 100,000. The same situation is in Disability- * Corresponding author.
Adjusted Life Years (DALYs): in 1990 the rate was 11.77 DALYs per
100,000; in 2003 - 14.7 DALYs per 100,000; in 2016 - 11.61 DALYs Background and aims.– Patients with serious mental disorder have
per 100,000. poorer access to health care than the general population. Little is
Conclusions.– In Russia the high risk both of the incidence and mor- known about the end of life care outcomes for this patient group.
tality from anorexia nervosa in women under 20 years old remains. Our aim was to investigate acute health care in the last 3 months
Such parameters as YLDs and DALYs in these patients became more of life and place of death in patients with serious mental disorder
constant as it was in 1990. using linked, routinely collected data.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Data were extracted from mental health records, the
interest statement. South London and Maudsley (SLAM) Clinical Record Interactive
Search (CRIS) database. These data were linked with Hospital
Episode Statistics (HES) and mortality data. Patients were included
E-PP0525 if they had a serious mental disorder, died between 2007–2015
Schizophrenia is associated with and had complete death registry data. Descriptive analysis assessed
chronic kidney disease beyond A&E visits, hospitalisations and place of death.
Results.– Data were analysed from 1536 patients known to SLAM
demographic, medical, and behavioral
mental health care services. Most patients visited A&E at least once
risk factors: a retrospective matched (58.3%) and had at least one admission (58.3%) in the last 3 months
cohort study of life. Furthermore, 10.6% had ≥3 A&E visits and 11.4% had ≥3
D. Tzur Bitan1* , I. Krieger2 , B. Anat3 , D. Comaneshter4 , A. Cohen4 admissions in the last 3 months. Hospital was the most common
1 Shalvata Mental Health Center, Psychiatric ER, Hod Hasharon, place of death (48.2%) followed by home (32.2%).
Israel; 2 Shalvata mental health center, management, Hod Hasharon, Conclusions.– These preliminary results show that most patients
Israel; 3 Sheba Medical Center, Sheba Medical Center- affiliated with accessed hospital services near the end of life and nearly half of all
the Sackler School of Medicine, Tel Aviv, Israel; 4 Chief Physician’s patients died in hospital. Using linked, routinely collected data is
Office, Clalit Health Services, Tel Aviv, Israel an effective way of assessing end of life care outcomes in patients
with serious mental disorder. This project will explore the role of
health care services at end of life for these patients.
Background and aims.– The aim of this study was to examine
the association between schizophrenia and chronic kidney dis-
interest statement.
ease (CKD) among a large cohort of schizophrenia patients with
matched-controlled participants. A secondary purpose was to
assess the level of accessibility that these patients had to common E-PP0527
treatments for CKD, as compared to the control group.
Methods.– We employed a retrospective matched-controlled
End of life care and place of death in
cohort design which included 27,516 patients diagnosed with adults with serious mental illness: a
schizophrenia and an equal number of age and gender frequency- systematic review
matched controls, using the Clalit Health Services (CHS) databases, R. Wilson* , N. Hepgul, I.J. Higginson, W. Gao
the largest managed care organization in Israel. Diagnostic validity King’s College London, Cicely Saunders Institute, London, United
was highly confirmed prior to the initiation of the study. Hierarchi- Kingdom
cal logistic regression models were fitted to assess the association
between schizophrenia and CKD beyond demographic, behavioral,
and medical risk factors. ROC curves were conducted to assess level Background and aims.– People with serious mental illness (SMI)
of sensitivity and specificity of the models. have greater mortality risk than the general population. They expe-
Results.– Schizophrenia was associated with CKD, after control- rience inequalities in accessing health care throughout life; it is not
ling for age, gender, socioeconomic status, congestive heart failure, clear if this persists to end of life. Our aim was to systematically
hyperlipidemia, diabetes, hypertension, smoking, and obesity review the empirical evidence assessing end of life care and place
(OR = 1.75, CI 1.58–1.94, p < .0001). Schizophrenia patients with of death for people with SMI.
Methods.– We conducted a systematic review, searching 5 online E-PP0529

databases and additional sources for primary research reporting Night shift work, mental health and
health care utilisation in the last year of life or place of death in
sleep disorders in young clinical
people with SMI.
Results.– After full text screening, 18 studies were included; 10
doctors
reported health care access at end of life and 11 reported place of A. Fki* , M. Hajjaji, N. Kotti, Z. Hakim, K. Jmal Hammami, M.L.
death. We found studies that reported hospital admissions, emer- Masmoudi
gency department care, palliative care and GP visits at end of life. Hedi Chaker Hospital, Occupational Medicine, Sfax, Tunisia
We found conflicting evidence for the association between SMI and
end of life care, although different patient groups, settings and mea- Background and aims.– Training doctors are thought to experience
sures were used across studies. People with SMI were more likely increased mental strain in comparison to other occupations.
to die in care homes than the general population. There were no The aim of the present study was to detect psychological distress
patterns for other places of death. and sleep disorders among young female doctors who are engaged
Conclusions.– We found a paucity of research and there was great in night shift work and to analyze related risk factors of doctors’
heterogeneity across studies, demonstrating little consensus over mental health.
end of life care and place of death in people with SMI. Given that Methods.– We conducted a cross-sectional study among training
people with SMI have increased mortality risk, this gap in the doctors working in a university hospital in Tunisia. The data were
knowledge around end of life care outcomes is concerning; this collected using a pre-established form with socio-occupational
area of research needs further development. characteristics, the Spiegel sleep questionnaire and the 28-item of
Disclosure of interest.– The authors have not supplied a conflict of general health questionnaire.
interest statement. Results.– Forty-four young doctors answered the questionnaire.
Their average age was 26.84 years old. Respondents were married
in 40.9% of cases, 36.8% of whom had children in charge. The average
E-PP0528
number of hours of work per week was 47 hours. The average num-
Mental health and sleep disorders ber of night shift work per month was 5 with compensatory rest in
among female training doctors 20% of cases. Sleep disorders were found in 36.4% of cases, of which
A. Fki* , Z. Hakim, N. Kotti, N. Rmadi, K. Jmal Hammami, M.L. 9.1% had a severe disorder. Psychological distress was observed in
Masmoudi, M. Hajjaji 79.5% of cases. Sleep disorders were statistically associated with
Hedi Chaker Hospital, occupational medicine, Sfax, Tunisia the absence of compensatory rest after night shift (p = 0.011), with
task requiring high concentration (p = 0.022) and with insufficient
pauses during labor (p = 0.038).
Background and aims.– Doctors are vulnerable to psychiatric mor- Conclusions.– Mental health problems among junior doctors per-
bidity as a result of their busy schedules and multiple role forming night work are common. Awareness of these risks is
obligations. justified through the implementation of the strategy of prevention
We aimed to identify the possible indicators of mental health, psy- and promotion of wellness and mental health awareness among
chological distress, and sleep disorders in young female physicians. these young doctors.
Methods.– We conducted a cross-sectional study among residents Disclosure of interest.– The authors have not supplied a conflict of
and interns working in a University Hospital in Sfax, Tunisia. interest statement.
The data were collected using a pre-established form with socio-
occupational characteristics, the Spiegel sleep questionnaire and
the 28-item general health questionnaire. E-PP0530
Results.– A total of sixty three female training doctors participated
Epidemiologycal study: involuntary
in the survey. The population had an average age of 27.27 ans. The
married women were represented by 52.4% and 28.5% of them had admissions in a psychitric
children in charge. The respondents worked an average of 43 hours hospitalization unit
a week. More than the half of the doctors (58.7%) estimated that L. Gallardo Borge* , P. Marqués CAbezas, M. Gómez García, E.
breaks during work were insufficient. Sleep disorders were found Rodríguez Vázquez, L. Rodríguez Andrés, A. Rodríguez Campos, G.
in 31.7% of cases, of which 9.5% had a severe problem. A psycho- Medina Ojeda
logical distress was observed in 82.5% of the respondents. Sleep Hospital Clínico Universitario, Psychiatry, Valladolid, Spain
disorders were statistically associated with a high number of hours
of work per week (p = 0.032), the number of nightshifts per month
Background and aims.– The involuntary admissions are nowadays
(p = 0.030) and having children in charge (p = 0.009).
in a discussion, in fact, some associations work for their abolition
Conclusions.– To minimize the risk of poor mental health in doctors,
and try to impose the patient’s wish. It is said that the ratio of invol-
screening and professional intervention services should be pro-
untary admissions reflect characteristics of National Health System
vided at early career stages to raise physicians’ awareness about the
and their lows.
importance of maintaining psychological well-being and to reduce
Aim.– Estimate the prevalence of involuntary admissions in a Psy-
the prevalence of psychological symptoms.
chiatric Hospitalization Unit of the Clinical Hospital of Valladolid,
just as the epidemiological and clinical variables, from January to
interest statement.
June of 2017.
Methods.– Descriptional prospective study of patients that were
involuntary admitted in a Psychiatric Hospitalization Unit.
Results.– Total admissions: 249 patients. Involuntary admissions:
61 (24,92%); 54,1% males, 45,9% females. Average: 45,30 years.
Involuntary admission cause: 37,7% psychotic symptoms, 23% civil
incapacity, 21,3% agitation, 14,8% severe suicide attempt, 3,3% court
order.
Type of admission: 3,2% ordinary, 96,8% emergency.
Clinical diagnosis: 62,3% psychotic disorders, 14,8% affective disor- environment in chemical industry and its influence into mental
ders, 23% other disorders (personality, drug abuse, anorexia). We health of workers – is the arm of investigation.
found a significative stadistically association between the cause of Influence of combination of occupational noise and volatile sol-
involuntary admission and the clinical diagnosis (p = 0,006) vents of organic solutions (acetone, benzene components) into
Agitation during the admission: 82% no, 18% yes. We found a signi- workers physical and mental health were studied.
ficative stadistically association between agitation and the cause of Methods.– Hygienic assessment of the main occupational factors –
involuntary admission (p = 0,0058). No association with diagnosis, chemical, physical, the severity and intensity of the work processes.
sex or age. Mental health examination was carried out for 86 workers dur-
Conclusions.– Our results showed that males and middle age were ing periodical medical examination on the mentioned conditions.
predictors of involuntary admissions. As clinical characteristics the Experience in the profession, psycho-hygienic assessment of occu-
patients presented a psychotic diagnosis and no agitation episode pational factors and personality features of workers were especially
during their admission. From the knowledge of these sociodemo- take into consideration
graphic and clinical characteristics we could do intervenvetions to Results.– Maximum allowable concentration (MAC) of phenol annu-
prevent this kind of admissions and increase the satisfaction and ally was exceed in 0,3–1,3 times. The rest of chemical agents
empowerment of patients. were under MACs.(1). During medical examination of workers no
Disclosure of interest.– The authors have not supplied a conflict of one occupational disorder was diagnosed. Some cases of transient
interest statement. leukopenia were registered among workers of phenol-acetone
words, which could be a marker of the toxic influence of benzene
into blood system. (2). Among people with neurotic and organic
E-PP0531 psychiatry symptoms group of workers in phenol-acetone words
Effect of foster care on bed utilization has nonspecific mental symptoms which is not included into DSM.
in a veteran population They depend of occupational conditions: long professional expe-
R. Gurrera* , D. Grosso rience, general patterns of staged of mental health symptoms,
VA Boston Healthcare System, Mental Health Service, Brockton, USA common clinical signs, typical for occupational conditions.
* Corresponding author. Conclusions.– Mental health differences are specifically depended of
the characteristic of working conditions, especialy among chemical
Background and aims.– industry
Introduction.– Community-based foster care for individuals with Disclosure of interest.– The authors have not supplied a conflict of
serious mental illness (SMI) originated more than 600 years ago interest statement.
in Geel, Belgium. Despite its durability as an alternative model of
long-term support for patients, it occupies a marginal position in
care planning for individuals with SMI in the United States, but E-PP0533
the Department of Veterans Affairs has administered a foster care Improving detection and treatment of
program for decades. mental disorders in community
Objectives.– To examine clinical bed program utilization before and
settings: development, validation and
after foster home placement in a consecutive cohort of Veterans
with SMI. evaluation of community informant
Methods.– All Veterans placed in a foster home between October 1, detection tool in Nepal
2007 and September 30, 2013 were included. Bed days for hospital N.P. Luitel1* , B.A. Kohrt2 , M.J.D. Jordans3
and residential treatment programs were tabulated for each sub- Transcultural Psychosocial Organization TPO- Nepal, Research,
ject, by bed type, during symmetric pre- and post-placement time Kathmandu, Nepal; 2 George Washington University, Department of
intervals. Psychiatry, Washington DC, USA; 3 King’s College London, Institute of
Results.– The sample included 140 Veterans (129 men) with median Psychiatry- Psychology and Neuroscience, London, United Kingdom
placement duration of 562 days. Post-placement psychiatric bed
utilization was reduced in 97 of the 117 (82.9%) patients with psy-
chiatric beds days during the pre-placement period, for a mean Background and aims.– Accurate detection of persons in need of
reduction of 77.5% (p < .01). Residential treatment program bed mental health care is crucial to reduce the treatment gap between
utilization was also reduced in all 20 patients with residential treat- psychiatric burden and service use in low- and middle-income
ment bed days during the pre-placement period, with a mean 99.8% countries. Community case finding by lay community workers par-
reduction (p < .01). ticularly in resource poor countries could be advantageous. The aim
Conclusions.– Foster care is associated with significant reductions in of this study was to develop, validate and evaluate the accuracy and
psychiatric hospital and residential treatment program utilization, effectiveness of a community-based proactive case-finding strat-
and has the potential to reduce long-term costs associated with egy called Community Informant Detection Tool (CIDT).
persistent serious mental illness. Methods.– The CIDT was developed following multiple steps
Disclosure of interest.– The authors have not supplied a conflict of including prioritization of symptoms, assessing applicability and
interest statement. feasibility. Validation was conducted by using Composite Interna-
tional Diagnostic Interview (CIDI) as a gold standard with 195 adults
screened with CIDT. The CIDT was evaluated with 509 community
E-PP0532 residents identified as potentially having MNS problems through
the CIDT procedure three weeks after detection.
The influence of occupational risk
Results.– The CIDT comprises of contextualized vignettes using
factors on the mental health of the local idioms of prioritized symptoms with illustrations. The CIDT
chemical industry workers has a positive predictive value of 0.64 and a negative predictive
S. Kuzmina* , E. Mukhametshina value of 0.93. The probable positive cases identified through CIDT
Kazan State Medical University, Psychiatry, Kazan, Russia are encouraged to visit the health facility, where diagnosis and
treatment is available. Of the total 509, 67% accessed health care
facility as a result of the CIDT procedure. Among the group that
Background and aims.– Industrial factors is included in the def-
accessed health care, 77% were diagnosed having mental disorders
inition of “environmental health” and could play the important
and started treatment by primary health care workers
role in mental health of workers. Evaluation of occupational
Conclusions.– The CIDT can be used by lay community members compliance, enhancing the skills of daily living, socialization, voca-
with low literacy levels. It holds potential psychometric properties tional training, and meaningful employment.
to increase detection and care utilization of mental disorders in Aim.– The impact of the Psychiatric rehabilitation program for psy-
settings with limited treatment engagement chiatric patients offered at the Karwan E Hayat Institute of Mental
Disclosure of interest.– The authors have not supplied a conflict of Health Care.
interest statement. Methods.– A retrospective evaluation approach was followed. Data
was selected from Karwan e Hayat.
A total of 127 Participants, who fulfilled the inclusion criteria of a
E-PP0534 minimum of 6 months of taking medicine or psychiatric Rehabilita-
Factors predicting 30-day readmission tion service and diagnosis of schizophrenia & bipolar disorder were
in psychiatric patient population on selected from inpatient and outpatient clinics for this study. The
Participants were divided into three groups; Rehab, Short Rehab
an inpatient unit
and Control group. An evaluation checklist was developed to assess
P. Manocha1* , M. Zeshan2 , R. Cheema3 , J. Chowdhury1 , M.
the level of functioning of the clients. The evaluation checklist
Desmukh1 , S. Vargas1 , D. Bhullar1 , Z. Ahmad1 , A. Hanif1 , W. Gu1 ,
composed of gender, age, work performance, Global Assessment
K. Frischer4
1 BronxCare Health System, Psychiatry, Bronx, USA; 2 Boston Functioning (GAF), Activities of Daily Living (ADL) and Relapse rate.
Results.– Rehab and Short Rehab group was showing significant
Children’s Hospital, Harvard Medical School, Child and Adolescent
improvement (P ≤ 0.05 level) on the work performance and Activi-
Psychiatry, Boston, USA; 3 Baylor College of Medicine, Child and
ties of Daily Living (ADL) as compared to control group. GAF Scores
Adolescent Psychiatry, Houston, USA; 4 Kirby Forensic Psychiatric
was also showed better functioning in Rehab (76.2%) and Short
Center, Psychiatry, New York, USA
* Corresponding author. Rehab (69.8%) as comparable to control group (54.8%) from base-
line to follow up. The Relapse rate of Control group was higher as
Background and aims.– Hospital readmission within 30 day is a compared to Rehab and short Rehab group.
major issue in US and as per claims data from Medicare & Med- Conclusions.– The study indicated that the psychiatric rehabilitation
icaid, it cost us 26$ billion/annually. New York state established program of Karwan e Hayat has a positive effect on people with
DSRIP to restructure the health care delivery with goal of reduc- psychiatric disability.
ing readmissions by 25% over 5 years. DSRIP uses LACE score Disclosure of interest.– The authors have not supplied a conflict of
as an assessment tool for determining the high-risk patients for interest statement.
emergent hospitalizations in medicine, but LACE score has limited
validity to psychiatric patients. Tool developed for psychiatric hos-
pitalization, READMIT score incorporates a weighted scale based on E-PP0536
the factors. BLHC has developed a scale (ZAC score) that attempts The long-term effects of a
to incorporate factors specific to its own patient populations. self-management intervention using
Methods.– We scored the available tools LACE and READMIT for self-regulation theory on knee
170 patients, who were admitted to our inpatient units, to assess
symptoms and Physical function,
the accuracy of both measures in predicting psychiatric inpatient
readmission within 30 days. The sample consisted of consecu- health care outcomes, and quality of
tively admitted patients to our inpatient psychiatric units at Bronx life
Lebanon hospital. K. Mei-Hua1* , Y.F. Tsai2
1 Mackay Junior College of Medicine- Nursing- and Management,
Results.– Our patients were primarily males (58%), more often AA
(55%) and Hispanic (39%), and had a diagnosis of psychotic disorder Department of Nursing, new Taipei, Taiwan R.O.C.; 2 Chang Gung
(62%). Independent t-tests and receiver operating characteristics University, School of Nursing, Tao-Yuan, Taiwan R.O.C.
(ROC) analyses were differentiated in READMIT and ZAC score but
not for LACE.
Conclusions.– READMIT & ZAC scores were better in predicting 30 Background and aims.– The aim of this study was to explore the
day readmission in psychiatric setting when compared to LACE long-term effects of a self-management intervention using self-
score. The variables predicting early readmission in our data set regulation theory on knee symptoms and physical function, health
were severity of illness, non compliance and violent behavior prior care outcomes, and quality of life for middle-aged patients with
to readmission. Length of hospitalization was not a predictor for 30 knee osteoarthritis.
day readmission. Methods.– A longitudinal quasi-experimental design with repeated
Disclosure of interest.– The authors have not supplied a conflict of measures was applied for this long-term follow-up study. A con-
interest statement. venience sample of 125 knee osteoarthritis patients, aged 45–64
years, were recruited from two medical centers in northern
Taiwan. The effectiveness of the self-management intervention was
E-PP0535 evaluated with scores from the following self-assessment question-
naires: Knee Injury and Osteoarthritis Outcome Score, Healthcare
The impact of psychiatric
outcomes and the Short-Form Health Survey. Generalized estimat-
rehabilitation program: the KEH ing equations compared assessment scores for participants at 6
experiences months and 12 months after the intervention with scores at base-
N. Mehmood1* , U. Talib2 , Y. Gohar3 line.
1 Karwan E Hayat Institute of Mental Health Care, Research & Results.– When compared with baseline, scores for knee symptoms
Development, Karachi, Pakistan; 2 Karwan e Hayat institute of and physical function scores significantly improved and quality of
mental health care, Medical, Karachi, Pakistan; 3 Karwan E Hayat life significantly increased; body mass index, unplanned medical
institute of Mental Health care, Rehab, Karachi, Pakistan consultations, and doses of pain medication significantly decreased
at 6 and 12 months. l After adjusting for the effect of time and signif-
icant related factors, knee symptoms and physical function, body
Background and aims.– The People with psychiatric disability expe-
mass index, doses of pain medication, and quality of life signifi-
rience difficulties in their living, working, learning, and social
cantly improved at 6 and 12 months compared with baseline.
environments. They have needs related to psychiatric treatment
Conclusions.– The long-term effects of the self-management inter- Methods.– A cross-sectional descriptive and analytical study, of 50
vention for knee osteoarthritis using self-regulation theory could trainee doctors practicing in HédiChaker university Hospital of Sfax.
significantly improve participants’ knee symptoms and physical TorontoAlexithimia Scale TAS-20: to evaluate alexithymia and Bar-
function, reduce body mass index and doses of pain medication, ratt Impulsiveness Scale BIS-10: to study impulsivity.
and improve overall quality of life. Results.– The average age of young doctors was27,64 ± 1.95 years
Disclosure of interest.– The authors have not supplied a conflict of old. The Sex ratio = 0.61 (19 M/31 W)They were married in 52%.
interest statement. They are smokers in 14% and consume alcohol in 6%. They are
practicing in “A” category services (surgical, intensive care, radi-
ology and psychiatry services) in 74% of cases. They had Family
E-PP0537 medical antecedents in 64% of case. TAS-20:the average score was
Self-regulation 52.02 ± 10.48 and the prevalence of alexithymia was 18%. BIS-
theory-self-management intervention 10:average motor impulsivity score was 21.62 ± 4.09, cognitive
impulsivity score was 23.92 ± 4.16 and non-planning impulsivity
for middle-aged adults with knee
score was 24.06 ± 4.19. The average total score was 67.62 ± 10.37.
osteoarthritis Impulsivity is significantly associated with practicing in Category
K. Mei-Hua1* , Y.F. Tsao2 A services with (p = 0.046). The factors significantly correlated with
1 Mackay Junior College of Medicine- Nursing- and Management, alexithymia were: practicing in “A” Category services (p = 0.04) and
Department of Nursing, new Taipei, Taiwan R.O.C.; 2 Chang Gung impulsivity (p < 0.00).
University, School of Nursing, Tao-Yuan, Taiwan R.O.C. Conclusions.– The results of our study join those found in
other lands; they underline the link between alexithymia and
Background and aims.– The aim of this study was to explore the impulsivity. Psychological support aimed specifically alexithymic
long-term effects of a self-management intervention using self- dimension is indispensable for young doctors.
regulation theory on knee symptoms and physical function, health Disclosure of interest.– The authors have not supplied a conflict of
care outcomes, and quality of life for middle-aged patients with interest statement.
knee osteoarthritis.
Methods.– A longitudinal quasi-experimental design with repeated
E-PP0539
measures was applied for this long-term follow-up study. A con-
venience sample of 125 knee osteoarthritis patients, aged 45–64 Psychosocial characteristics of
years, were recruited from two medical centers in northern individuals in online psychological
Taiwan. The effectiveness of the self-management intervention was counseling
evaluated with scores from the following self-assessment question- E. Nikolaev* , V. Ivanov, E. Lazareva
naires: Knee Injury and Osteoarthritis Outcome Score, Healthcare Ulianov Chuvash State University, Social and Clinical Psychology
outcomes and the Short-Form Health Survey. Generalized estimat- Department, Cheboksary, Russia
ing equations compared assessment scores for participants at 6 * Corresponding author.
months and 12 months after the intervention with scores at base-

line. Background and aims.– Online psychological counseling is gaining
Results.– When compared with baseline, scores for knee symptoms ground in Russia notwithstanding proven efficiency of a traditional
and physical function scores significantly improved and quality of face-to-face practice. What are the social characteristics and speci-
life significantly increased; body mass index, unplanned medical ficity of psychological problems in those people who turn to online
consultations, and doses of pain medication significantly decreased help?
at 6 and 12 months. After adjusting for the effect of time and signif- Objectives.– Below, you will find the results of the analysis of psy-
icant related factors, knee symptoms and physical function, body chosocial characteristics of the people who were counseled by
mass index, doses of pain medication, and quality of life signifi- online private psychologist within a half year.
cantly improved at 6 and 12 months compared with baseline. Methods.– 115 people aged 18–67 who had been counseled by
Conclusions.– The long-term effects of the self-management inter- online psychologist filled in a questionnaire and SCL-90-R. The
vention for knee osteoarthritis using self-regulation theory could obtained findings have undergone a mathematic processing based
significantly improve participants’ knee symptoms and physical on basic statistics methods.
function, reduce body mass index and doses of pain medication, Results.– Prevailing were the people aged 40–55 (44.3%), females
and improve overall quality of life. (86,1%), university graduates and undergraduates (73.9%), mar-
Disclosure of interest.– The authors have not supplied a conflict of ried (46.0%), urban residents (91.3%), people unsatisfied with their
interest statement. financial status (89.6%), those who experienced mental problems
for a long time (70,4%), and those who considered themselves
healthy (46,0%). Comparing the people with prolonged mental
E-PP0538 problems with those who turned to psychologist for personal devel-
The relationship between impulsivity opment issues, we found that the first differ (p < 0.001), from the
latter group by their lower level of mental health according to
and alexithymia among trainee
SCL-90-R. They have shown more evident somaticized complaints,
doctors in Tunisia obsessive-compulsive symptoms interpersonal sensitivity, depres-
N. Messeddi* , M. Ben Abdallah, M. Bejjar, F. Charfeddine, L. Aribi, sion, anxiety, hostility, phobias, paranoid ideation, psychoticism,
O. Amami and PSDI Index.
HédiChaker University Hospital, Department of Psychiatry B, Sfax, Conclusions.– Online psychological help is more often sought for by
Tunisia mature employable married urban females who have a university
degree, but who are unsatisfied with their financial status and who
Background and aims.– A few studies examined the relationship have been experiencing prolonged mental problems. They do not
between the impulsive dimension and alexithymia among young associate psychological distress and some symptomatic disorders
doctors. The objectives of this study are to evaluate alexithymia in a with their health.
group of trainee doctors, to study their impulsivity and determinate Disclosure of interest.– The authors have not supplied a conflict of
the link between these two entities. interest statement.
E-Poster Presentation: Ethics and Psychiatry - De-escalation training (threat and violence situations)Person-
centered projects in the aim of improving care and reducing
compulsion
- Global trigger tool for tracking possible errors in coercive mea-
E-PP0540
sures
Euthanasia: the silent plea - Focus on consistency in scheduling staff
A.T. Carvalho, J. Silva Results.– As a result of the work done since 2015, forced measures
Centro Hospitalar Tâmega e Sousa, Psychiatry, Porto, Portugal has shown a trend downwards, as shown in Figure 1, until August
2018.
Background and aims.– Physician-assisted suicide and euthanasia
(PAS-E) refer to the termination of one’s suffering through painless
methods, when the person so desires. Throughout the years, there
has been a lot of controversy regarding this issue, as it raises major
ethical questions concerning the meaning and value of human exis-
tence or in which possible circumstances can it be justifiable, if at
all? It is still considered a crime in many countries. Recently, in
Portugal, after extensive debate and controversy, the Government
has ruled against the legalization of PAS-E. In this review, we aim
to examine the literature available on PAS-E and to reflect on the
impact that comes with accepting it.
Methods.– We carried out a non-systematic literature review by Figure 1 Compulsory treatment per patient.
performing a search on MedLine for English-written articles. The
Conclusions.– Regular and focused education efforts have helped
query used was “euthanasia”, “ethics” and “assisted” and “suicide”.
to raise awareness on compulsory care in all staff, and to create
Results.– Nowadays, many physicians, particularly those in the
new models for person-centered work in order to reduce coercive
fields of oncology and palliative care, are faced with requests for
measures.
assistance in dying. The majority of these requests comes from can-
cer patients, although the frequency is increasing in other terminal
interest statement.
conditions. Usually these patients are suffering from unimaginable
pain, are functionally very limited, albeit having intact cognition,
meaning they are very aware of their demise. E-PP0542
Conclusions.– Although PAS-E does raise a lot of moral dilemmas, it
is possible to understand the concept of wanting to die with dignity.
Social stigma towards people with
That being said, where should people stand (mainly physicians, as it mental disorders among the
goes against their Hippocratic oath) regarding this delicate subject? psychiatrists, general practitioners
Disclosure of interest.– The authors have not supplied a conflict of and inters
interest statement. K. Kandratsenia
Minsk City Psychiatric Clinic, Outpatient Department, MINSK, Belarus
E-PP0541
More care, less coercion: finding new Background and aims.– Many patient’s symptoms are made worse
ways to deal with challenges in by the stigma and discrimination they experience - from society,
compulsory mental care in Affektiva from families, but also from doctors and interns. The attitudes
of health care professionals indicates the need to change way of
Psychiatry Clinic, Sweden thinking towards patients, both for social rehabilitation and for
M. Dellepiane
treatment in general.
Sahlgrenska University Hospital, Psykiatri Affektiva, Gothenburg,
Methods.– Simultaneous, transverse research with comparison and
Sweden
* Corresponding author. control groups. Number of participants in a study - 101 people from
psychiatric hospital, outpatient department, general hospitals.
Background and aims.– Compulsory treatment may be overwhelm- Results.– Not only general society but also medical professionals
ing and traumatic and may constitute an obstacle for a good and not always understand the features of mental disease. According
trustful long-term alliance between caregivers and patients. to the MICA 4 scale the majority of respondents received a suffi-
Psychiatry Clinic Affektiva in Gothenburg, has been working sys- ciently high number of points. According to emotional exhaustion
tematically to reduce compulsory measures since 2015. By focusing scale (BSMU, SEE) the general practitioners have the highest level of
on education and exploring alternative and preventive methods to emotional exhaustion — 60%, psychiatrists —31,5%, interns —18,2%.
handle difficult situations in inpatient care settings we aimed at an 31,5% of psychiatrists, 60% general practitioners and 18,2% interns
increased awareness and changed attitude in order to create a safe have a high level of emotional exhaustion. Emotional Empathic
and secure environment in our units. Tendency Scale shows that more than a half of participants concider
Our aim was reduce coercive measures, particularly by heighten their empathy level as average (psychiatrists - 74,1%, general prac-
awareness for healthcare professionals to find alternative solutions. titioners - 84%, interns - 77,3%) The majority of respondents think
Methods.– Several actions have been taken to reduce the coercive that health/social workers know more about the lives of people
measures in inpatient care: with mental illness than their family members or friends.
- Case based discussions for clinicians about ethical and clinical Conclusions.– Stereotypes and stigma towards people with mental
implications of compulsory treatment disorders have place even among psychiatrists, general practition-
- Case based discussions on Clinic Management levelEducation in ers and young doctors. It limits to improve social functioning and
compulsory treatment across all medical groups medical help. Also the majority of participants suffer from emo-
- Dialectical Behavioral Therapy training and tutorials tional exhaustion, that can influence on their work and attitude
towards the patient.
interest statement.
E-PP0543 Conclusions.– The work model reminded staff about the princi-
Sweet suicide: clinical case ples, empowered their professional decision-making, decreased
M. Mattia collegial conflicts because of increased acceptance for individual
Studio Mattia, Private Medical Office, Lugano-Paradiso, Switzerland decisions, and, in general, improved well-being at work. Further-
more, the work model also empowered staff to find support for
Background and aims.– AP is a man of 69. On august 2016 he received their decisions based on principles that are grounded in the ethics
the diagnosis: Adenocarcinoma at 4th stadium metastasized. A of totality.
month later, AP underwent a pelvic reconstruction. For six months Disclosure of interest.– The authors have not supplied a conflict of
he passed a positive period of life. Then he had a new fMRI scan interest statement.
which revealed the presence of new metastasis. A few days later,
his insisted in his desire to put end to his life.
Methods.– The Oncological Institute of the Italian Switzerland E-PP0545
(IOSI), where AP was admitted, supported his request, facilitating A retrospective study to ascertain the
contact with Exit (private Swiss Institution for suicide assisted). practice of assessment of mental
Results.– AP’s mental state has remained constantly clear. AP’s wife
has remained close to her husband. AP quitted his life on april
capacity to consent to an admission to
2016, drinking Pentobarbital. His wife was absolutely convinced the adult psychiatric ward
she would join her husband through her own assisted suicide. AP S. Siddiqui1* , U. Ahmed2
1 NHS, Psychiatry, Dewsbury, United Kingdom; 2 NHS, Psychiatry,
was able to choose assisted suicide because he demonstrated no
egoistic intention, and had no other possibility of cure. What would Liverpool, United Kingdom
happen to AP’s wife if she were not be admitted into a program of
assisted suicide? Would she kill herself?
Background and aims.– Mental Health Professionals must act to safe-
Conclusions.– The controversy on suicide is religious, philosophical,
guard the rights of vulnerable people and they need to ensure that
political and historical. Although the majority of general praction-
any deprivation of liberty of a person who lacks capacity to consent
ers and nurses in Switzerland agree with the practice of assisted
to admission is authorised in accordance with the appropriate legal
suicide in cases such as oncological or neuro-vegetative disease,
framework
opinion concerning assisted suicide in the presence of severe men-
Aims and objectives.– To determine whether capacity assessments
tal disorder switches dramatically to the opposite position. Why?
were being carried out and documented when patients were admit-
We will try to discuss the implications present in the controversy
ted to the general adult acute wards in secondary care.
between acceptation and non acceptation of sweet death in somatic
To determine if there is a difference in the capacity assessments
and psiychiatric state.
documentation between patients admitted voluntarily compared
with patients detained under the mental health act.
interest statement.
Methods.– This was a retrospective study. Data was collection using
the centralised computer record system for all patients admitted to
E-PP0544 the four adult inpatients wards in secondary care in two neighbour-
ing towns
Using participatory action research to Results.– There were 21 admissions during the study period. 43%
develop a working model that (n = 12) were females and 57% (n = 12) were males. 86% (n = 18)
enhances Psychiatric nurses’ were admitted voluntarily and 14% (n = 3) were admitted under
professionalism: the architecture of the mental health act framework. The capacity to decide about the
admission was assessed in 23% (n = 5). Out of these 4 were volun-
stability
tary patients and 1 under mental health act. Therefore 22% (n = 4)
M. Salzmann-Erikson
vouluntary patients and 33% (n = 1) under mental health act had
University of Gävle, Faculty of Health and Occupational Studies-
capacity assessment completed.
Department of Health and Caring Sciences, Gävle, Sweden
Conclusions.– This study has highlighted the need to improve
Background and aims.– Ward rules in psychiatric inpatient care aim the practice of assessing mental capacity for admission and to
to promote safety for both patients and staff. Simultaneously, ward document it accordingly. The study findings were used to raise
rules are associated with increased patient violence, leading to nei- awareness and a memorandum was issued for the relevant pro-
ther a safe work environment nor a safe caring environment. The fessionals to improve the practice.
objectives in this study were to describe the process of a team Disclosure of interest.– The authors have not supplied a conflict of
development project considering ward rule issues, and to develop interest statement.
a working model to empower staff in their daily in-patient psychi-
atric nursing practices.
Methods.– The design of this study is explorative and descriptive. E-PP0546
Participatory action research methodology was applied to under- Medical malpractice in clinical and
stand ward rules. Data consists of audio recorded group discussions, forensic psychiatry in Poland – what
observations and field notes, forming 556 text pages. From deep we (don’t) know?
involvement and interaction with the staff over time, we con- A. Skowronek1* , R. Skowronek2 , M. Krzystanek3 , C. Jabłoński2
structed data by a process driven accumulation of insights from 1 Outpatient Clinic for Mentally and Nervous Sick NZOZ “Integritas”,
reciprocal interpretations. Outpatient Clinic for Mentally and Nervous Sick NZOZ “Integritas”,
Results.– More than 100 specific ward rules were identified. Rules Oświ˛ecim, Poland; 2 Medical University of Silesia in Katowice,
was relinquished in favor of adopting the term principles, since Department of Forensic Medicine and Forensic Toxicology, Katowice,
rules are inconsistent with a caring ideology. A linguistic transition Poland; 3 Medical University of Silesia in Katowice, Department of
led to the development of a framework embracing the (1) Principle Rehabilitation Psychiatry, Department of Psychiatry and
of Safety, (2) Principle of Structure and (3) Principle of Interplay. The Psychotherapy, Katowice, Poland
principles were linked to normative guidelines and applied ethical * Corresponding author.
theories: deontology, consequentialism and ethics of care.
Background and aims.– Mistakes made by physicians are inevitable, with premeditated aggression had an equal prevalence of sub-
which is why more and more often efforts are being made to imple- stance use, anxiety and depressive disorders. Patients with ASPD
ment appropriate monitoring and prevention systems. According and impulsive aggression showed a lower PCL-R score (p < 0.01,
to US data, a medical error can be the third cause of death after CI = 3.55; 9.31).
cardiovascular disease and cancer. The objective of authors was Conclusions.– Aggression in ASPD is mainly of impulsive type.
an attempt to characterize the problem of medical error in Polish Aggression categorization in ASPD patients should be regarded
psychiatry. with interest by clinicians, has it could guide treatment selection.
Methods.– (1) Analysis of interdisciplinary forensic expert opinions Disclosure of interest.– The authors have not supplied a conflict of
prepared in the Department of Forensic Medicine in Katowice in interest statement.
cases suspected of medical error. (2) Review of Polish literature
on the issue of medical malpractice in psychiatry and available
E-PP0548
statistical data.
Results.– The most frequent situations that raise doubts among Antisocial personality disorder with or
close relatives of patients and result in notifications to the prose- without psychopathy present distinct
cutor’s office about the possibility of making a medical error are: Psychiatric co-morbidities and family
suicides (in wards and after referral from the hospital emergency history – new paths of diagnostic and
department), sudden deaths of patients during or shortly after
the use of direct physical restraint, sudden deaths of patients
therapeutic investigation?
J. Azevedo1* , M. Castelo-Branco2 , R. Coelho1 , M. Figueiredo-Braga1
with alcohol withdrawal syndromes, incorrect pharmacotherapy, 1 Faculdadede Medicina da Universidade do Porto, Departamento de
wrong diagnosis of somatic states, “detoxification” with the use
Neurociências clínicas e Saúde Mental, Porto, Portugal; 2 Faculdade
of psychoactive drugs at home with the subsequent death of the
de Medicina da Universidade de Coimbra, IBILI - Institute for
patient. There is no data available in the literature that would
Biomedical Imaging and Life Sciences, Coimbra, Portugal
allow full characterization of the problem of medical malpractice * Corresponding author.
in Polish psychiatry.
Conclusions.– Lack of a system for monitoring medical errors in psy- Background and aims.– Previous studies have emphasized ASPD and
chiatry makes it impossible to take appropriate preventive actions. psychopathy overlap highly but differ in negative emotionality and
In this situation, an invaluable source of information are experi- possibly amygdala reactivity to social signals of threat and distress.
ences of the forensic medical departments involved in preparing The most common psychiatric comorbidities in antisocial personal-
opinions on such cases for legal authorities. ity disorder (ASPD) are substance use (SUD), depressive and anxiety
Disclosure of interest.– The authors have not supplied a conflict of disorders. Etiology aspects in ASPD and psychopathy include an
interest statement. unfavorable family context, with the frequent presence of major
psychiatric disorders, alcohol and drug use disorders, and crimi-
nality in the parents. We hypothesized that ASPD and psychopathy
E-Poster Presentation: Forensic Psychiatry - Part I could present distinct psychiatric co-morbidities.
Methods.– We evaluated a sample of 89 male inmates with: Mini
International Neuropsychiatric Interview, Psychopathy Checklist-
Revised, Addiction Severity Index – European Version (Family
E-PP0547
section).
Impulsive aggression as a marker for Results.– Patients with ASPD had a higher prevalence of substance
antisocial personality disorder - a use disorders (SUD) when compared to individuals without ASPD
study in male inmates (p < 0.05, OR = 2.67 CI = 1.14, 5.39). Patients with psychopathy had
J. Azevedo1* , R. Coelho1 , M. Castelo-Branco2 , M. Figueiredo-Braga1 a higher prevalence of SUD (p < 0.05, OR = 2.35, CI = 1.05, 5.27)
1 Faculdade de Medicina da Universidade do Porto, Departamento de and a lower prevalence of depressive disorders (p < 0.05 OR = 0,37,
Neurociências clínicas e Saúde Mental, Porto, Portugal; 2 Faculdade CI = 0.10, 1.04). Patients with ASPD showed higher prevalence of
de Medicina da Universidade de Coimbra, Institute for Biomedical family history of alcohol use disorders (p < 0.01, OR = 4.10 CI = 1.29,
Imaging and Life Sciences IBILI-, Coimbra, Portugal 11.34). Patients with psychopathy had a higher prevalence of family
* Corresponding author. history of alcohol use disorders (p < 0.01, OR = 5.92 CI = 2.18, 16.11)
and a higher prevalence of family history of psychiatric disorders
Background and aims.– Aggression can be conceptualized as a physi- (p < 0.05, OR = 3.02 CI = 1.14, 7.99).
cal act towards another person with the intent to harm. It is a symp- Conclusions.– The lower prevalence of depression in psychopaths
tom of various psychiatric disorders, and a core feature In Antisocial could be related to the specific emotional processing in psy-
Personality Disorder (ASPD). Aggression is highly frequent, resis- chopaths. Family background cloud be more disruptive in
tant to treatment and responsible for adverse clinical and forensic psychopaths, both through a disadvantage environment and
outcomes. In order to improve aggression clinical management, the genetic alterations. Present results recommend further research
characterization as impulsive or premeditated aggression may be into diagnostic and therapeutic approaches.
relevant. A large body of literature correlates impulsive but not Disclosure of interest.– The authors have not supplied a conflict of
premeditated aggression with biological disturbances that can be interest statement.
positively addressed by pharmacological treatment.
Our aims were to determine the prevalence of impulsive aggres-
sion in ASPD and its relation with specific personality traits and
co-morbid psychiatric disorders.
Methods.– A sample of 96 male ASPD inmates was assessed by a
battery of clinical and psychometric standardized instruments: the
Mini International Neuropsychiatric Interview, the Psychopathy
Checklist-Revised (PCL-R), the Addiction Severity Index – European
Version, the Barratt Impulsivity Scale eleven’s version (BIS-11) and
the Impulsive Premeditated Aggression Scale.
Results.– Inmates with ASPD had a prevalence of impulsive aggres-
sion of 71.9%; ASPD patients with impulsive aggression and those
E-PP0549 Methods.– We studied a sample of 134 male inmates with a battery

Premeditated aggression is predicted of clinical and psychometric standardized instruments: the Mini
by Psychopathic traits in antisocial International Neuropsychiatric Interview, Psychopathy Checklist-
Revised, Addiction Severity Index - European Version, Barratt
personality disorder male inmates Impulsivity Scale eleven’s version and the Impulsive Premeditated
J. Azevedo1* , M. Castelo-Branco2 , R. Coelho1 , M. Figueiredo-Braga1
1
Aggression Scale. In a subsample of 48 individuals, we measure
Faculdade de Medicina da Universidade do Porto, Departamento de
erythrocyte COMT activity.
Results.– S-COMT erythrocyte activity is positively correlated to
de Medicina Universidade de Coimbra, IBILI - Institute for Biomedical
self-control first order factor of BIS-11 (rho = 0.624, p = 0.001) in
Imaging and Life Sciences, Coimbra, Portugal
individuals with SUD. SUD’s patients had higher scores in self-
control factor (p = 0.048, CI = −0.49, −0.03), higher scores in PCL-R
Background and aims.– Psychopathy is related but is not equivalent (p = 0.014, CI = -6.43, −0.75) and in F3 – antisocial facet (p = 0.009,
to antisocial personality disorder (ASPD), a psychiatric diagnose CI = −2.78, −0.42)SUD’s patients had a lower prevalence of violent
that emphasizes individual behaviour rather than emotional dys- crimes (p = 0.005, OR = 0.34, CI = 0.16, 0.73), a higher prevalence of
function. Nevertheless, ASPD can be co-morbid with psychopathy ASPD (p = 0.011, OR = 2.67, CI = 1.23, 5.78), and an higher prevalence
in severe cases. One of the distinguishing characteristics of ASPD of psychopathy (p = 0.035, OR = 2.35, CI = 1.05, 5.28).
and psychopathy is the greater risk for aggression, which can be of Conclusions.– SUD patients Individuals with a higher COMT activ-
impulsive or premeditated type. In both entities aggression is not ity can have a hypodopaminergic prefrontal state due to a higher
inhibited throughout personality development, but instead there COMT activity. COMT activity can be a pharmacological target in
is a learning process in which aggression can be used as preferen- individuals with SUD. We can possibly treat SUD patients with
tial mechanism to deal with adverse situations or to gain personal COMT inhibitors being the rational that inhibiting COMT activity
and social advantages. Aggression represents a public health issue will lower choice impulsivity and improve self-control.
having a negative impact on individuals and society. We hypothe- Disclosure of interest.– The authors have not supplied a conflict of
sized that ASPD individuals with psychopathy cloud have a distinct interest statement.
impulsive/premeditated aggression prevalence compared to ASPD
individuals without psychopathy, underscoring emotional dys-
E-PP0551
function predictive value.
Methods.– We evaluated a sample of 97 ASPD patients with a bat- Investigating the role of childhood
tery of clinical and psychometric standardized instruments: Mini victimization in criminal recidivism
International Neuropsychiatric Interview, Psychopathy Checklist- among a sample of male inmates: a
Revised and the Impulsive Premeditated Aggression Scale. cross-sectional study
Results.– ASDP patients with psychopathy had a higher preva- E. Capuzzi* , F. Besana, M. Bava, M. Capellazzi, S. Mauri, T. Tabacchi,
lence of premeditated aggression when compared to ASPD patients I. Tagliabue, E. Truisi, M. Clerici
without psychopathy (p < 0.001, OR = 5.56, CI = 2.14, 14.40). F1 University of Milano - Bicocca, Department of Medicine and Surgery,
interpersonal facet of PCL-R predicted premeditated aggression Monza, Italy
type (p < 0.05, Exp (B) = 1.42, CI = 1.03, 1.95). * Corresponding author.
Conclusions.– The type of aggression in ASPD patients can be influ-
enced by the presence of psychopathic traits. Interpersonal facet Background and aims.– In most countries the percentage of repeat
1 seems to be a predictive factor of premeditated aggression. The offenders has been increasing1 . Many factors, including fam-
presence of emotional dysfunction can alter behavioral decisions ily background, education, occurrence of mental illness with,
and modify the type of aggressive behavior of ASPD patients. especially, substance use disorder, may predict the recidivism2 .
Disclosure of interest.– The authors have not supplied a conflict of Moreover childhood maltreatment increases the risk of repeat
interest statement. offence and, among specific types of victimization, neglect might
be a strong predictor of recidivism3 .
To examine associations among childhood victimization and crim-
E-PP0550 inal recidivism.
S-comt erythrocyte activity is Methods.– We enrolled 215 male inmates. Recidivism was defined
correlated to self-control in substance as the occurrence of one or multiple new convictions for any kind of
offense. So the sample was divided, according to presence of recidi-
use disorder patients
vism, into two groups, compared for sociodemographic and clinic
J. Azevedo1* , M.A. Vieira-Coelho2 , P. Serrão2 mpvserrao@gmail.
characteristics. History of childhood victimization was assessed
com, M. Castelo-Branco3 , R. Coelho1 , M. Figueiredo-Braga1
1 Faculdade de Medicina da Universidade do Porto, Departamento de with the Childhood Trauma Questionnaire Short Form (CTQ-SF)4 .
The presence of specific trauma (emotional, physical and sexual
abuse; emotional and physical neglect) was determined by meeting
de Medicina da Universidade do Porto, Departamento de
a threshold of moderate maltreatment severity5 .
Farmacologia e Terapêutica, Porto, Portugal; 3 Faculdade de Medicina
Results.– At univariate analyses, subjects with (n = 124) and without
Universidade de Coimbra, IBILI - Institute for Biomedical Imaging and
recidivism (n = 91) exhibited a statistically significant association in
Life Sciences, Coimbra, Portugal
* Corresponding author. the scores of physical neglet (p = 0.00) and abuse (p = 0.03). How-
ever, logistic regression analyses showed that only physical neglet
Background and aims.– Substance use disorders are character- was associated with recidivism (OR:2.32, 95% CI: 1.03–5.21). More-
ized by reward dysfunction and decision making disruption. over lower education, dual diagnosis and gambling were related to
Dopamine pathways are relevant in decision making, reward, and an increasing likelihood of criminal recidivism (Table 1).
choice impulsivity. Dopamine metabolism in prefrontal cortex is Conclusions.– Childhood maltreatment is associated with recidi-
dependent on Cathechol-O-metiltransferase. We aim to test the vism. In particular, physical neglect during childhood plays a critical
hypothesis that prefrontal hypodopaminergic individuals with a role in repeated crime, in relationship with mental, substance use
higher COMT activity will have higher scores on self-control first disorders and pathologic gambling. A careful evaluation of child-
order factor of Barratt impulsivity scale – eleven version. hood maltreatment in the assessment and treatment of criminal
offenders could be needed.
Background and aims.– The relationship between criminal behavior

and mental illness has always attracted research interest. However,
few studies have analyzed the association between bipolar disorder
and criminal offending.
The study aims to examine criminal offending in former Tunisian
inpatients with bipolar disorder.
Methods.– A retrospective descriptive study of bipolar patients who
have been hospitalized at least once in the psychiatric ward of the
Fattouma Bourguiba Hospital in Monastir between January 2000
and December 2016.
Results.– We examined medical records of 117 patients. Mean age
Table 1. factors associated with criminal recidivism: multiple logis- was 41,69 (±12,87) years. The average duration of illness was 12,56
tic regression analyses (±11,61) years. The sample was predominantly male, single, of
medium socioeconomic status and with irregular employment sta-
Disclosure of interest.– The authors have not supplied a conflict of tus. We found a problematic substance use in 18,8% and a history
interest statement. of criminal record in 15,4% of our patients. In addition, 53,8% have
committed, at least once a lifetime, a criminal offense. Examining
the 216 criminal offenses, different crimes were committed, with
E-PP0552 physical assault (33,6%), verbal assault (33,2%), damage to property
The characteristics of Italian forensic (8,3%), being the most frequent. Most of criminal offenses occurred
patients in a psychiatric facility more frequently during severe manic episodes (89,25%). Justice
C. Cargioli* , L. Polese lucia, G. Orsolini involvement was found in 9,72% of criminal offenses with incarcer-
SRP Tiziano, North-Western Tuscany Region Local Health Unit, Aulla, ation in 7,41%, criminal irresponsibility in 1,85% and guardianship
Italy in 0,46%. In our study, criminal offending was statistically asso-
* Corresponding author. ciated with addictive behavior, history of a criminal conviction,
dominant manic polarity, number and duration of prior hospital-
Background and aims.– Since 2002, the residential psychiatric facil- izations.
ity “Tiziano” (Massa Carrara, Tuscany) hosts forensic patients, on Conclusions.– Identifying associated factors with criminal offending
appointment with mental health departments and compulsorily seems to be substantial to prevent violent behavior, hospitaliza-
admitted by the justice system. This report would describe epi- tions and incarceration of bipolar patients.
demiological, clinical, and criminological features of mentally ill Disclosure of interest.– The authors have not supplied a conflict of
offenders restrained in Italian psychiatric facilities. interest statement.
Methods.– We examine medical records of 60 mentally ill offenders
hosted in the “Tiziano” facility between 2002 and June 2016.
Results.– Most forensic patients were male (90%, N = 54; E-PP0554
male/female = 10/1); the average age was 33 years. Sixty per- Evaluation of an alleged necrophile,
cent of subjects (N = 36) had a clinical diagnosis of psychosis, and acquitted for compulsively digging up
about one third of them (31.6%, N = 19) had at least a personnality
disorder. Mental insufficiency was diagnosed in 11.6% (N = 7) of
human remains — how to
subjects, while substance use disorder affected 35.0% (N = 21) and differentiate vandalism from
alcohol use disorder 26.6% (N = 16). Forty-nine patients (81.7%) psychiatric morbidity, using interview
had committed serious crimes against people; 46.7% (N = 28) had and Psychometric data
committed more crimes. The average length of stay is 22 months. D. Sendler, G. Dosadinski*
Up to June 2016, 43 patients had been discharged from “Tiziano” Felnett Health Research Foundation, Laboratory of Forensic Sexology,
facility more than a year ago: 20% were at home, 50% in a different Legal Medicine, and Digital Ethnography, Staten Island, USA
facility, 30% in a detentive structure (forensic psychiatric hospital; * Corresponding author.
residences for the execution of security measures; jail). Of 23
patients discharged more than 5 years ago, 35% were at home, 30% Background and aims.– Necrophilia is a paraphilia whereby the per-
in a different facility, 15% in a detentive structure, and 20% were petrator gets sexual pleasure from fantasizing, or acting on, the urge
dead. to have sex with a corpse.
Conclusions.– There is a lack of data about long term follow-up of Methods.– Evidence for this study comes from two sources — clinical
this kind of patients. Additional studies are needed to define psy- interview with the defendant, and police forensic evidence.
chopatological and criminological features, in order to differentiate Results.– In mid-November 2017, regional police unit contacted our
treatment and to avoid a relapse. lab concerning a case of 54-years-old grave digger. The man has
Disclosure of interest.– The authors have not supplied a conflict of been compulsively going on a spree of digging up graves at local
interest statement. cemeteries, removing select body parts, packing them into plastic
bags, and transferring to a different location in a nearby forrest. The
mode of his actions is atypical for an act of vandalism, organized
E-PP0553 crime, or religiously-motivated profanation. Given lacking history
Criminal offending among patients of sexual thoughts, or acts, involving human corpses, we excluded
the possibility that he is a necrophile. Instead, we diagnosed him
with bipolar disorder: a study about
with antisocial personality disorder co-morbid with OCD.
117 bipolar inpatients Conclusions.– Our reasoning through this complex clinical case has
I. Chaari1* , B. Amamou2 , B. Ben Mohamed2 , L. Gaha2 practical value for other clinicians evaluating paraphilias.
1 Fattouma Bourguiba University Hospital, Department of Psychiatry, Disclosure of interest.– The authors have not supplied a conflict of
Monastir, Tunisia; 2 Faculty of Medicine of Monastir University of interest statement.
Monastir, Research Laboratory “Vulnerability to psychosis”, Monastir,
Tunisia
E-PP0555 The interest of this study is to go further than criminology and

The relationship between emotion forensic, questioning both the unableness of many security services
regulation processes and criminal to regard animal killing as a serious previous-sign of future vio-
lences on humans as well as the lack of interest/understanding of
antecedents in a sample of male post-modern societies for the deviant profiles of serial killers they
inmates produce.
A. Galhardo1* , B. Loisas2 , M. Cunha1 , I. Massano-Cardoso3 Conclusions.– The conclusion will emphasis on practical recommen-
1 Instituto Superior Miguel Torga and Faculty of Psychology and dations to psychiatrists, security and police services, their trainings
Educational Sciences of the University of Coimbra, Cineicc, Coimbra, to identify this kind of profile and associated links to Psychiatry
Portugal; 2 Instituto Superior Miguel Torga, Psychology, Coimbra, itself, in addition to the judicial necessity to maintain a full personal
Portugal; 3 Instituto Superior Miguel Torga and Faculty of Medicine of responsibility in the most of these repetitive crimes.”
the University of Coimbra and Faculty of Economics of the University Disclosure of interest.– The authors have not supplied a conflict of
of Coimbra, Ceisuc, Coimbra, Portugal interest statement.
Background and aims.– Previous studies have identified several E-PP0557

criminal risk factors among prisoners. Nevertheless there are still
variables that were not sufficiently explored. These include emo-
Clinical audit and service evaluation
tion regulation processes, such as self-compassion, self-judgment project of prison healthcare wing
and self-control. This study aimed to address the relationship HMP Chelmsford
between emotion regulation processes and criminal antecedents N. Hallett, S. Abkari, M. Nazir, K. Beverly, B. David, D. Ho*
in a sample of inmates. Forensic psychiatry, Brockfield House, Essex, United Kingdom
Methods.– A total of 91 male prisoners were recruited, aged
between 22 and 65 years old, the mean age being 38.05 (SD = 9.93)
years. For data collection, the Self-compassion Scale and the Self- Background and aims.– Enabling prisoners to access specialist psy-
Control Scale were used. chiatric care is essential given the psychopathology and numbers
Results.– Self-compassion and self-judgment scores were similar of suicides in prison. There are often significant delays in transfer-
to those found in community samples. Regarding low self-control, ring prisoners to the healthcare wing and external hospitals which
particularly impulsivity, results indicated that this variable seems poses significant risks.
to be present in a more pronounced way in younger subjects, lower This project aims to audit the care of prisoners in the healthcare
educated and presenting an earlier start of criminal behaviour. wing of HMP Chelmsford, United Kingdom. It will use the stan-
Conclusions.– Study limitations include the small sample size, and dards in the National Institute of Clinical Excellent NICE - NG 66,
recruitment procedure, which may have introduced biases in the the Royal College of Psychiatrists - CCQI268 and local standards in
results. In addition, the absence of a social desirability measure may HMP Chelmsford - SSOP62 and SSOP64.
also be a limitation. However, the study allowed identifying vari- Methods.– This project will look at all prisoners admitted to the
ables such as impulsivity and self-judgment, which may be directly healthcare wing from 1st June 2017 to 1st June 2018. Data will
integrated in intervention programs targeting this population. A be collected using prison medical records relating to a number of
reduction in impulsivity and self-judgement may, in turn, promote parameters including length of stay, time to transfer to hospital,
a decrease in low self-control. diagnoses, types of medication given and risk assessments.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Preliminary results suggest that there is wide variation in
interest statement. the length of stay and time for transfer to hospital. Most prison-
ers have multiple medications. Risks assessments are limited but
are generally clearly documented. There were 84 prisoners in the
E-PP0556 healthcare wing during the study period.
Conclusions.– Although further data collection and analysis of data
Criminology and psychiatry according
is underway, preliminary results suggest that clinical practice gen-
to the fbi research: animal-killing as a erally meets the clinical audit standards. However looking at the
milestone towards serial-killer service evaluation as a whole, there is wide variation in outcomes
profiling for prisoners particularly regarding transfer to hospital.
D.F. Gandus Disclosure of interest.– The authors have not supplied a conflict of
La Sorbonne Human Sciences studies, HS and Philosophy of Sciences, interest statement.
Paris, France
Background and aims.– E-PP0558

Introduction: FBI research has established a very strong tie between Influence of child and adolescent
the beginnings of serial-killers activities and animals as their pre-
vious victims before they attack humans.
abuse on psychiatric disorders and
Objectives: The main objective of this presentation will be to criminal activity in adult women
demonstrate, both statistically and in terms of meaning, the rel- M. Kachaeva1* , S. Truchelev1 , L. Nazarova2 , N. Skibina3
1 Federal Medical Research Center for Psychiatry and Narcology
evancy of the FBI observations, with an enlarged spectrum on the
notions of pervert enjoyment to make suffer, specificity of the serial named after VP Serbsky, Forensic Psychiatric, Moscow, Russia; 2
killing aspect in our times, as well as we will deal with the progres- Sechenov First Moscow State University, Chair of Social and Forensic
sion from animal to human killings. Psychiatry, Moscow, Russia; 3 Sechenov First Moscow State Medical
Methods.– Studying both statistics, the sociological environment University, Chair of Social and Forensic Psychiatry, Moscow, Russia
of serial killers, interviews of serial killers, associated to a lived
experience I have got confronting this kind of profiles while I saved
Background and aims.– Researches on female offenders have indi-
several animals from their hands should help us to understand this
cated a high degree of psychiatric morbidity amongst women. Since
problem.
the rates of female criminality are rising it would appear important
Results.– The reason why they begin with animals can be put in
to conduct the study of the relationship between criminal behav-
relation with the long-term process ending with human-killing.
ior and psychiatric diagnoses in female offenders. Objectives. The E-PP0560

main purpose of this investigation is to find out origins of crimes in Psychiatry of radicalization and
women and to reveal the influence of child and adolescent mal-
terrorism
treatment on personality disorders in adult women.
C. Lazzari* , M. Rabottini
Methods.– Clinical psychopathological, psychological, statistical.
International Centre for Healthcare and Medical Education,
Results.– A cohort of 22 females with diagnosis of personality disor-
Psychiatry, Wakefield, United Kingdom
ders was examined. All of them had committed crimes of violence. * Corresponding author.
In the majority of the sample women had a previous history of psy-
chiatric admissions (child psychiatric hospitals, adolescent units). Background and aims.– Mental-health professionals are in the front
The retrospective review revealed that the majority of women in line for assessing and preventing radicalization and potential ter-
their childhood were exposed to emotional, physical and sexual rorism. Understanding the thought processes of a radicalized mind
abuse in their families. Our results point that maltreatment may is at the forefront of prevention.
distort personality formation and social adjustment and contribute Methods.– Ethnographic research and narratives of people who are
to behavior problems, negative relation to socialization and crimi- radicalized can help understand the processes behind the patho-
nal behavior in adulthood. logical thoughts that override moral judgment and lead to terrorist
Conclusions.– The study revealed that psychiatric disorders in attacks.
child-hood and adolescence are predictive of adult criminality in Results.– Lack of empathy for the victims of a terrorist attack is
females. This findings may be used as prognostic indicators of generated by the processes of cognitive separation and paranoid
development of aggression in female forensic patients. generalization. During the Stage of Cognitive Separation (SCS), the
Disclosure of interest.– The authors have not supplied a conflict of radicalized person does not think of victims as individuals but
interest statement. as a group representing what that the terrorist hates. A physical,
emotional and psychological separation between the radicalized
terrorist and his or her victims reduce empathy and moral con-
flicts towards the own actions. During SCS, the radicalized person
appears more aloof, inaccessible, and persuaded about his or her
beliefs. During the following stage of Paranoid Projection (PP),
the targeted victims are progressively defined by their nega-
tive attributes via cognitive distortions including absolutism and
projection. During PP, a process of victimization ensues where dis-
torted cognitive beliefs about potential victims are reinforced to
reduce cognitive dissonance between moral judgment and planned
actions.
Conclusions.– The current commentary highlights the role of
mental-health professionals in spotting mental radicalization and
in preventing that people who are potential victims of radicaliza-
tion reach the final stage of a process where thoughts and actions
are hard to change.
interest statement.
E-PP0561
A belgian cohort of maternal filicide
S. Leistedt1* , X. Bongaerts2 , J.P. Beauthier3
1 Université Libre de Bruxelles ULB Laboratory of Psychiatry Research,
Forensic Mental Health Hospital Les Marronniers, TOURNAI, Belgium;

2 Psychiatric Hospital le Chêne aux haies, Forensic Psychiatry, Mons,
Belgium; 3 Université Libre de Bruxelles, Forensic Pathology, Brussels,

Belgium
Background and aims.– The tragedy of maternal filicide has occured

throughout history and throughout the world. It is a complicated
and multidimensional phenomenon with various characteristics,
motivation, risk factors and patterns.
The objective of this study is to examine the psychopathological
profiles, including motivational factors, of women who committed
neonaticide, infanticidal or filicidal acts.
Methods.– This study was based on data gathered through a ret-
rospective chart of filicidal women recorded in different area of
Belgium between 1990 and mid-2018. These women were deeply
evaluated (behavioural forensic evaluations) at the beginning of
their trials by the authors. All the data of this study were obtained
through the first forensic evaluation.
The authors have also examined the modus operandi and other
chronological circumstances of the child death.
Results.– 58 women (N = 58) were included in our sample. 48
women were either found not competent to stand trial, or found
not guilty by reason of insanity. These 48 women were suffering
from different mental disorders and/or personality disorders (Axe mental illness, who does not recognize the necessity for medical
1 and 2 of the DSM-V). In 55 (on 58) women, several social and intervention. According to the Portuguese Mental Health Law, an
familial problems were also prevalent. individual compulsorily admitted to acute care may be discharged
Conclusions.– The psychopathological profiles of women who com- in Involuntary Outpatient Treatment (IOT), if he is considered, by
mitted filicide is highly heterogenous. Psychiatric diseases, social his psychiatrist, to be at risk of abandoning the therapeutic plan.
problems, and familial conflicts were highly prevalent and allow The study aims to discern factors associated with exiting in IOT.
the authors to define several clinical clusters. These clusters and Methods.– We reviewed the discharge notes of all consecutive
their characteristics should be included in the behavioural forensic compulsorily admitted patients, from January 2011 to December
evaluations of these women. 2017. After the Chi-Square test to choose significant variables,
Disclosure of interest.– The authors have not supplied a conflict of we performed a logistic regression, with backward elimination,
interest statement. to determine which factors were associated with a discharge in
IOT. We report adjusted odds ratio with a 95% confidence interval.
Statistical significance was set at p < 0.05.
E-PP0562 Results.– IOT was positively associated with more than 20 days of
Transitional pathways among young hospitalization (OR = 1.65 [1.03, 2.64]; p = .02), F20 spectrum diag-
people discharged from forensic child nosis (OR = 2.37 [1.45, 3.87]; p < .01), prescription of long-acting
injectable (OR = 7.24 [3.44, 15,24]; p < .01) and anticholinergic
and adolescent mental health
medication (OR = 2,04 [1.09, 3.84]; p = .03) at discharge. Nega-
services: a retrospective national case tive association was found regarding prescription of antipsychotic
note audit polypharmacy (OR = .32 [.14, .72]; p < .01) and antidepressants
M. Livanou (OR = .49 [.26,.9]; p = .02) at discharge.
Kingston University, Psychology, Kingston Upon Thames, United Conclusions.– Results suggest that exiting in IOT is associated with
Kingdom a patient suffering from a psychotic illness that no longer needs to
stay in acute setting, but hasn’t gained insight into his illness.
Background and aims.– This study included young people transi-
tioning from all nationally funded medium secure adolescent units
interest statement.
to adult services in the UK during 2015 and 2016. Currently there is
lack of evidence in regard to young people’s needs during transition
from inpatient forensic child and adolescent mental health services.
To improve service provision during periods of transition, we have E-Poster Presentation: Forensic Psychiatry - Part
to explore young people’s backgrounds and needs transferring from II/Old Age Psychiatry - Part II
these units.
Methods.– Retrospective case note reviews based on a predefined
proforma were used to retrieve cases’ information on demograph-
ics, family background including parental mental health difficulties, E-PP0564
parental criminality, clinical and offending characteristics, transi- The forensic mental health profile of
tional pathways, length of stay, and age at the time of the actual women offenders in South Africa
transition to adult placements. M. Nagdee
Results.– Thirty-two patients were discharged from forensic child Rhodes University, Psychology, Grahamstown, South Africa
and adolescent mental health services to adult services (forensic
psychiatric units), including community placements (residen- Background and aims.– There is a paucity of research on forensic
tial settings, supported community accommodation) and prison. mental health issues of women offenders in South Africa, especially
Selected cases are displayed in the form of case studies to illus- in respect of life histories, nature of offences or the psycho-social
trate young people’s profiles and transitional pathways to and from context of offending. This study examined the psycho-social pro-
forensic child and adolescent mental health services. All 32 young file of women offenders referred by courts for forensic psychiatric
people had comorbid mental health problems and learning disabil- evaluation. Socio-demographic, criminological, clinical and foren-
ities. The most common discharge destinations were community sic variables were investigated.
placements and adult medium secure hospitals. Methods.– A retrospective record review of 173 cases from Fort
Conclusions.– The findings of this study highlight the multiple needs England Hospital (a forensic mental health hospital, Eastern Cape,
of this group as they move from child-oriented to adult-centred South Africa) was conducted. Chi-squared and logistic regression
mental health services. The intersection of repeated trauma, analyses were employed to test strengths of association and rela-
comorbid mental health difficulties, index offence and institution- tionships between variables and offending outcomes.
alisation compound to their complex profiles. The cycle of trauma Results.– Most women came from backgrounds of socio-economic
and inconsistent parenting experienced in family settings is per- adversity, with high pre-offence incidences of being victims of
petuated by multiple transitions across services. abuse themselves, mental ill-health and alcohol abuse. Violent
Disclosure of interest.– The authors have not supplied a conflict of offending comprised the majority of cases, with murder and aggra-
interest statement. vated assault accounting for half. Most victims of violence were
known to the offender, with biological infants of the offender being
particularly vulnerable. There were relatively high rates of psy-
E-PP0563 chotic disorders and psychiatric co-morbidity, though almost half
Factors associated with involuntary of the women were found to be both trial competent and criminally
responsible. Prior abuse of the woman offender was significantly
outpatient treatment following associated with future violent offending. Homicidal offences were
compulsory admission significantly more commonly perpetrated by women who had no
S. Martinho* , M. Simões psychiatric history. Children were significantly more likely to be
Leiria Hospital Centre, Psychiatry and Mental Health, Leiria, Portugal victims of homicide by women who were both younger and not
mentally ill.
Background and aims.– Compulsory treatment regards the legal
means to impose a therapeutic plan to an individual, affected by
Conclusions.– Gender-sensitive forensic mental health approaches Methods.– Sixty male chronic schizophrenic patients were recruited
should be employed in South Africa to progressively influence pol- from an inpatient hospital setting, thirty with criminal records
icy, legislative, clinical and research endeavours in this field. and thirty without any criminal history, patients with cognitive
Disclosure of interest.– The authors have not supplied a conflict of impairment, thyroid or supra renal glands dysfunction and co-
interest statement. morbid drug abuse were excluded. All subjects were subjected
to Brief Psychiatric Rating scale BPRS, criminal thinking style was
assessed using the short version of Psychological Inventory of Crim-
E-PP0565 inal Thinking Styles PICTS.
Analysis of forensic mental health Results.– Higher general raw score of PICTS among schizophrenic
care in the czech republic – current patients without criminal records could be attributed to the fact
that they were hospitalized for longer periods within a structured
state and challenges
health care setting (table 1).
M. Páv1* , P. Skřivánková2
1 Psychiatric hospital Bohnice, Acute psychiatry, Prague, Czech
Republic; 2 Psychiatric Hospital Bohnice, Acute Inpatient Psychiatry
Unit, Prague, Czech Republic
Background and aims.– Ministry of Health and Care Services

requested an Analysis of Forensic Mental Health Care in the Czech Table 1. Results.
Republic (CR) necessary for transformation of psychiatric hospitals
Conclusions.– Compliance with treatment and hospitalization set-
and deinstitutionalization process.
tings may contribute to decrease criminal bias style of thinking
Forensic treatment (FT) in CR is provided to offenders who com-
among male patients with chronic schizophrenia.
mitted a crime in a condition of absent or diminished responsibility
due to a mental disorder in outpatients or inpatient units or foren-
interest statement.
sic facilities. Currently, there are 13 facilities providing specialized
inpatient psychiatric treatment, substance abuse treatment and sex
offender treatment programs.
E-PP0567
Methods.– The forensic mental health care system in CR was ana-
lyzed from the year 2007 till 1.7.2018. Data were collected from 13 Alexithymia, impulsivity, anger in
psychiatric hospitals and from Institute of Health Information and violent schizophrenic patients
Statistics of CR. instituzionalized in an italian forensic
Results.– Number of inpatient FT is steadily increasing, with 948 psychiatric hospital: a cross sectional
patients in the year 2018; similar incremental increase was found
study
also within outpatient FT. Data collection system is insufficient.
J. Santambrogio1,2* , E. di Giacomo2,3,4 , M. Clerici2,3 , F. Di Nardo5 , A.
Problematic issue also is, that young offenders are treated with
Levita6,7 , A.G. Madia8 , M. Magistro Contenta9 , A. Todaro10 , N.
adults, special facility is absenting. In part of hospitals FT patients
Rosania6
are treated together with other patients. Whole system is financed 1 AS.FRA. Onlus, Casa San Paolo, Vedano al Lambro, Italy; 2 University
exclusively by health insurance.
of Milano-Bicocca, Department of Medicine and Surgery, Monza,
Conclusions.– Results are discussed in context of forensic mental
Italy; 3 ASST–Monza, Mental Health and Addiction Department,
health care transformation. There is a need of foreclosure of foren-
Monza, Italy; 4 Doctorate School of the University of Milano-Bicocca,
sic treatment from regular inpatient care. Transformation consists
PhD program in Neuroscience, Monza, Italy; 5 CTA Naso, Mental
also of Forensic multidisciplinary team’s establishment to prevent
Health Department, Messina, Italy; 6 Presidio Sanitario Casa
long-term hospitalization and systematic high-risk assessment of
Circondariale di Barcellona Pozzo di Gotto ME, Sanità Penitenziaria
offenders by standardized protocol. And unified methodology of
ASP, Barcellona Pozzo di Gotto ME, Italy; 7 AOUP “G. Martino”, AOUP
the forensic FT of children and adolescents will be provided. There
“G. Martino”, Messina, Italy; 8 ASP Messina, Mental Health
is obvious need to ensure multi-source funding of FT system.
Department, Messina, Italy; 9 Casa Circondariale Messina, Casa
Circondariale Messina, Messina, Italy; 10 IRCCS Neurolesi Bonino
interest statement.
Pulejo, IRCCS Neurolesi Bonino Pulejo, Messina, Italy
E-PP0566 Background and aims.– Understanding psychopathological mech-

Criminal thinking style among anisms underlying violence is essential to prevent relapses.
chronic hospitalized schizophrenic Alexithymia, impulsivity and anger are only some of the possible
patients factors causing aggression. Schizophrenic patients with violence
A. Rady* , A. Elsheshai, I. Abdelfattah history have over threshold STAXI-2 scores, showing how anger
Alexandria University School of Medicaine, Psychiatry, Alexandria, could predict aggression. Emotion disregulation can be a media-
Egypt tor between alexithymia and aggression, but there is no evidence
* Corresponding author. about impulsivity.
The purpose of this study (conducted in Barcellona PG forensic
Background and aims.– Studies from literature show higher fre- hospital before its disclosure) is to evaluate interactions between
quency of criminal activity among psychiatric patients compared alexithymia, impulsivity, anger and their influence on specific
to normal population. Authors suggested emotional recognition crimes in a group of violent schizophrenic patients.
deficit, co morbid substance abuse and poor compliance with Methods.– 53 schizophrenic subjects with crimes Vs. per-
medication. The construct of criminal thinking style reflects a ten- son/property were recruited and evaluated with TAS-20, BIS-11,
dency to adopt a specific relevant cognitive bias. Our study aims STAXI-2. Exclusion criteria: intellectual disability. Statistical analy-
at assessing criminal thinking style among patients with chronic sis: 2 test (non-continuous variables); t-test and post-hoc ANOVA
schizophrenia with or without criminal record. (continuous variables).
Results.– 53 subjects, mean age: 40,2. 15 (28%) patients E-PP0569

committed aggression/attempted homicide/sexual violence. 10 Profile of the victims of sexual offense
(19%) homicide/massacre. 11 (21%) persecutory acts/resisting
in Bulgaria
arrest/extortion/illicit gun possession. 6 (11%) theft. 10 (19%) fam-
L. Tumbev1* , P. Chumpalova1 , M. Stoimenova-Popova1 , E.
ily maltreatment. 24 (45%) ≥ 59 (BIS-11+); 9 (15%) STAXI-2 over
Krysteva1 , P. Popov2 , K. Stoychev1 , V. Valtchev3
75◦ percentile (STAXI-2+) (7 with Anger Expression Index over 75◦ 1 Medical University, Psychiatry and Medical Psychology, Pleven,
percentile). TAS-20 mean score: 55. BIS-11 mean score: 58. STAXI-2 Bulgaria; 2 Ministry of Health, National Center for Addictions, Sofia,
Anger Expression Index mean score: 59. Bulgaria; 3 National Sports Academy, Department of Biochemistry
Neither significant correlation (t-test) between TAS-20+ and BIS-
and Physiology, Sofia, Bulgaria
11+, nor between TAS-20+ and STAXI-2+, nor between crimes and * Corresponding author.
TAS-20+, STAXI-2+, BIS-11+.
With BIS-11+ as mediator, TAS-20+ and STAXI-2+ association was Background and aims.– Victims of sexual offense represent an
statistically significant for the variables T/A (trait anger) (p = 0,037), exceptionally heterogeneous group.
T/TA (trait temperament anger) (p = 0,011), Anger Expression Index The aim of our study was to evaluate the influence of specific socio-
(p = 0,025) demographic factors among victims of sexual offense.
Conclusions.– Alexithymia and impulsivity influence anger Methods.– The subjects of the study were 87 victims of sexual
construct. With impulsivity as a mediator, alexithymia and offense, who were testified by expert psychiatrist in the period from
trait/internalizing anger show their significant correlation. December 2010 until December 2016. We used patients’ records,
Disclosure of interest.– The authors have not supplied a conflict of providing information about different socio-demographic factors.
interest statement. Retrospective research was conducted of the available medical doc-
umentation.
Results.– Women (89,7%) are more often victims of sexual offense
E-PP0568 than men (10,3%). The highest percentage of victims are from the
Structured violence risk assessment in age groups between 11–15 years old (52,9%). 59.8% of the victims
youth live in a city. We did not find statistically significant differences
P. Skrivankova1* , M. Pav2 , M. Hrdlickova3 , I. Paclt2 according to the level of education and ethnicity. Statistically signif-
1 First Faculty of Medicine- Charles University and General University icant greater proportion of the victims are mentally healthy (87.3%).
Hospital, Department of Psychology, Prague, Czech Republic; 2 First 35.6% of victims have an acute stress reaction after the rape.
Faculty of Medicine- Charles University and General University Conclusions.– According to our study, girls aged between 11–15
Hospital, Department of Psychiatry, Prague, Czech Republic; 3 years old, who are mentally healthy, are more likely to became
Thomayer’s University Hospital, Children’s Center, Prague, Czech victims of sexual offense.
Republic Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– Ministry of Health and Care Services

requested an Analysis of Forensic Mental Health Care in the Czech E-PP0570
Republic (CR) considering an increase of hyped serious violent Exploring the relationship between
crimes. A new forensic team was established to create a procedure pension income and sense of shame
of a structured violence risk assessment focusing on juveniles.
There is no diagnostic tool for the violence risk assessment in youth
amongst elderly individuals
in CR standardized to identify juveniles who are at high risk of com- D. Mazetas1* , S. Mantzoukas2 , I. Vlachos3 , M. Gouva1 , K.
mitting a violent crime, while we know, that preventive approach Karamanis4
1 University of Ioannina, Research Laboratory Psychology of Patients
today prevails.
Methods.– Literature review was performed and the scale for Families and Health Professionals, Ioannina, Greece; 2 University of
violence risk assessment in youth SAVRY was chosen for stan- Ioannina, Research Laboratory Integrated Health, Care and
dardization based on comparison of the effectiveness of particular Well-being, Ioannina, Greece; 3 TEI of Thessaly, Postgraduate Program
tools. Thirty juvenile participants were recruited from psychiatry “Primary Health Care”, University of Thessaly- Larisa- Greece, Larisa,
inpatient clinic and tested by SAVRY, a scale of aggression SADDS, Greece; 4 University of Ioannina, Finance, Preveza, Greece
personality questionnaire HSPQ and a Conners scale.
Results.– Preliminary results show, that SAVRY is valid and reliable Background and aims.– Background: There are relatively limited
tool for the violence risk assessment in youth in CR. We show results studies exploring the relationship between elderly individuals’
of this pilot study, as well as results from a recently conducted pension income and their sense of inferiority in countries with eco-
survey into the clinical value and applicability of the SAVRY. nomic hardship or financial crisis. In specific, the characteristics of
Conclusions.– In conclusion, this project will contribute to the shame in elderly individuals is not usually taken into account and
enrichment of the list of effective tools that can lead to a reduction related to financial hardship or economic crisis.
of violence in CR and to the implementation of the first diagnostic Aim: This study aimed at identifying the relationship between
tool for assessing the risk of violence amongst juvenile. This tool elderly individuals’ pension income, and the sense of external and
that contributes to the implementation of the risk-need responsiv- internal shame of pensioners.
ity model in the Czech Republic. Methods.– The total sample included 476 pensioners with a mean
Disclosure of interest.– The authors have not supplied a conflict of age 70.11 (SD = 14.22). The participants in the study completed a)
interest statement. the Other As Shamer Scale-OAS, b) the Experience of Shame Scale-
ESS, and c) questionnaire on socio-demographic information and
individuals’ monthly pension income.
Results.– Multivariate analysis was applied for analysing the data.
The results identified that elderly individuals with low monthly
incomes have the highest level feeling of inferior (OAS) (7,04), total
external shame (OAS) (19,74), feeling of emptiness (OAS) (4,15),
and mistakes (OAS) (7,43).
Conclusions.– It could be argued that the results of this study, Background.– Cognitive assessments are essential for the diagnosis
despite of the reasonable limitations, leads to a redefinition of views of neurocognitive disorders (NCD). Performance in standardized
about the impact of personal salary and pension on the sense of cognitive tests is influenced by schooling. Most neuropsychological
external and internal shame. tests have been developed for populations with good reading and
Disclosure of interest.– The authors have not supplied a conflict of writing performance.
interest statement. Aims.– To evaluate the diagnostic accuracy of neuropsychological
tests for NCD in low schooling (1-4 years of study) and illiterate
elderly.
E-PP0571 Methods.– The study was conducted in Brazil in 213 elderly living
Improving psychiatry prescriptions in a primary care unit catchment area between March 2016 and
among elderly patients: benefits of February 2017. The following tests were applied: Brief Cognitive
Screening Battery (BCSB), Consortium to Establish a Registry for
reducing potentially inappropriate
Alzheimer’s disease (CERAD), Forward and Backward Digit Span,
psychiatric prescriptions Subtest abstraction of Cambridge Cognitive Examination (CAM-
J.M. Pelayo-Teran* , E. Garcia-Fernandez, R. Landera-Rodriguez, Y. COG), and Mini-mental State Examination (MMSE). The diagnosis
Zapico-Merayo of NCD was made based on a psychiatric evaluation based on the
Hospital El Bierzo. Gerencia de Asistencia Sanitaria del Bierzo GASBI, criteria of the DSM-5. The area under the ROC curve (AUC) and
Servicio de Salud de Castilla y León SACYL, Psychiatry and Mental the best cutoff point were calculated for each cognitive test for the
Health, Ponferrada, Spain illiterate groups and low schooling.
Results.– In the illiterates, the largest AUC was MMSE (0.81) with
Background and aims.– Although potentially inappropriate psychi- sensitivity and specificity values of 72.7% and 79.6% for the cutoff
atric prescription (PIPP) is associated with risk of harm due to point of 17. In the low schooling, the AUC of the MEEM remained
adverse effects, it is frequently prescribed for elderly patients. The the largest (0.89) with sensitivity and specificity values of 100%
aim was to determine the prevalence of PIPP and to evaluate the and 63% for the cutoff point of 23. All neuropsychological tests had
efficacy of reducing this PIPP in elderly patients. lower psychometric qualities in the illiterate group compared to
Methods.– Patients of 65 or more years old with at least 1 psy- low schooling group.
chiatric prescription were recruited from a Mental Health service. Conclusions.– Neuropsychological tests present adequate psycho-
A psychogeriatric interview was performed including CGI, Yesav- metric qualities for populations with low schooling level. This
age, GAI, 2014 STOPP/START criteria and UKU side effects. Patients research is supported by FAPESP (process 2015/16412-1).
that fulfilled one STOPP/START criteria for psychiatric medications Disclosure of interest.– The authors have not supplied a conflict of
were offered a prescription adjustment and followed-up for 3 interest statement.
months. Differences were evaluated with Mann-Whitney’s U and
the Wilcoxon signed-rank test.
Results.– 72 subjets (55 females) were included. Mean age was E-Poster Presentation: Genetics & Molecular
74.68 years, 51.4% were independent. 62.5% subjects met at
least 1 STOPP or START criterium (most frequent STOPP: use of
Neurobiology/Neuroscience in Psychiatry
benzodiazepine, START: SSRI for anxiety). 9 adjustments were
not performed due to medical or patient criteria. 8 patients
returned to the previous medication. After the adjustment, patients E-PP0573
improved significantly in psychic (z = −4.366; p < 0.001), neurolog- Toxicological and pathophysiological
ical (z = −2.762; p = 0.006), autonomic (z = −2.079; p = 0.039) and influence of lead and protective
other side effects (z = −3.027, p = 0.002), Yesavage depression score
physiological power of glutathione
(z = −2.870; p = 0.004) and GAI score (z = −2.660; p = 0.008). 52.3%
experienced an improvement in the CGI score, 41.2% did not through the concentration of
changed and only 2 subjects worsened. malondialdehyde in the brain of rats
Conclusions.– A high percentage of elderly patients are receiving J. Jovanovic Mirkovic1 , C. Alexopoulos1* , G. Kocić2 , N. Miljković3
1 College of Nursing, Medicine, Ćuprija, Serbia; 2 Faculty of Medicine,
PIPPs. Application of standardized criteria and revision of prescrip-
tions in elderly psychiatric patients may help to reduce risk of side Biochemistry, Niš, Serbia; 3 General Hospital, Neurology, Ćuprija,
effects and to improve psychiatric outcomes. Serbia
interest statement.
Background and aims.– Lead contamination sources are products of
combustion in metallurgy and chemical industry, traffic, industrial
E-PP0572 wastewater and landfills. Professionally, workers in smelters and
foundries, paint industry, ceramic industry, batteries and accumu-
Accuracy of neuropsychological tests lators factories and factories of weapons and ammunition are most
for diagnosis of major neurocognitive exposed to lead. Every year, the industry produces about 2.5 million
disorder in elderly with low education tons of lead worldwide.
levels To examine the effect of chronic intoxication with heavy metals,
R. Pessoa1* , L.R. Leal1 , N.M.D.S. Chagas1 , D. Morais2 , A.J.D.L. lead (Pb) and the protective role of glutathione supplementation
Bomfim3 , M.H.N. Chagas2 (GSH) through the value of the secondary lipid peroxidation prod-
1 University of São Paulo- Ribeirão Preto Medical School, uct, malondialdehyde (MDA) in brain homogenate of Wistar albino
Neuroscience and Behavior Department, Ribeirão Preto, Brazil; 2 São rats.
Carlos Federal University, Department of Gerontology, São Carlos, Methods.– Monitoring of lipid peroxidation intensity was per-
Brazil; 3 São Carlos Federal University, Department of Psychology, formed by measuring the value of malondialdehyde in brain tissue
São Carlos, Brazil homogenates, spectrophotometrically.
* Corresponding author. Results.– Increased MDA values, such as the biochemical marker of
oxidative damage to cell membranes, indicate an enhanced lipid
Background and aims.– peroxidation process present in brain tissue homogenates due to
chronic Pb intoxication (from 1,01 ± 0,10 to 2,72 ± 0,35). Reduc- Background and aims.– Catatonia and neuroleptic malignant syn-
tion of MDA concentration in cases where experimental animals drome (NMS) are both conditions that can compromise survival.
received supplements glutathione (from 2,72 ± 0,35 to 2,29 ± 0,18). Several authors hypothesize these two conditions have a common
Conclusions.– Lead has a pronounced affinity for thiol groups which pathophysiological process. We aim to review the available data
form a stable mercaptides and thus inactivates systems in natural concerning the link between NMS and catatonia.
conditions. Added GSH supplements reduce its negative effects and Methods.– We conducted a Pubmed research to identify relevant
thus it is a desirable supplement and antioxidant in the detoxifica- articles published up to September 2018.
tion of reactive oxygen species in rats that were subjected to lead Results.– Some studies identified signs and symptoms with discrim-
poisoning. inatory power to differentiate these two entities. However, many
Disclosure of interest.– The authors have not supplied a conflict of of these signs frequently appear in both conditions, which limits
interest statement. their usefulness. Many researchers argue that NMS and catatonia
are two conditions on the same spectrum, and there are several
hypotheses concerning the nature of their link: NMS is an iatro-
E-PP0574 genic form of catatonia; catatonia is a risk factor for NMS; NMS is
Neurobiofeedback assisted a heterogeneous syndrome including both catatonic and noncata-
meditation: can we improve tonic symptoms due to antipsychotics. It has been speculated that
the use of antipsychotics intensifies the hypodopaminergic state
stress-responses in obstetrics and
associated with catatonia. On the other hand, based on clinical and
gynaecology doctors? pathophysiological differences, other authors claim NMS and cata-
R. Allen tonia are two different syndromes. Some researchers hypothesized
WA Health Department, King Edward Memorial Hospital, Perth, that NMS is a “motor syndrome” related to antipsychotic blockade
Australia of subcortical striatal D2 receptors and catatonia is a “psychomotor
syndrome” that results from a cortical GABAergic dysfunction.
Background and aims.– Conclusions.– There is no consensus to enable an answer to whether
Introduction.– Increasing research indicates that neurofeed- catatonia and MNS are two disorders on the same spectrum or
back training can alter neurocognitive and neurophysiological different entities. Clinical signs cannot assure an unmistakable dis-
responses compromised by stress. Neurobiofeedback meditation tinction and it will be necessary studies to clarify if there is a linkage
may improve the work performance, health and well-being of doc- and to identify possible neurobiological markers.
tors. The Muse device is a wearable headband EEG system using dry Disclosure of interest.– The authors have not supplied a conflict of
sensor technology to record brain activity, including alpha wave interest statement.
levels. It provides instantaneous audio feedback to assist medita-
tion.
E-PP0576
Objectives– This study aimed to quantify the impact of medita-
tion on the ability to regulate brain wave activity in high stress The relationship between biological
situations, control physiological stress responses and improve sub- rhytm differences and neurological
jective levels of well being in a sample of obstetric and gynaecology soft signs
doctors. Ş. Arslan1 , Y. Selvi2 , A. Üzer1 , B. Yücens1
Methods.– Twelve participants had their brain activity levels and 1 Afyonkarahisar Health Sciences University, Faculty of Medicine,
salivary cortisol measured before and after performing a surgical Psychiatry, Afyonkarahisar, Turkey; 2 Selçuk University, Faculty of
procedure. The participants completed three weeks of daily med- Medicine, Psychiatry, Konya, Turkey
itation using the Muse device for 20 minutes each day. On three * Corresponding author.
occasions participants were interviewed about their perceptions

and experiences. They completed self-ratings of distress (i.e., DASS Background and aims.– Introduction: Humans can be evaluated by
21) and performance. Quantitative data will be analysed statisti- morning and evening type in terms of circadian rhythms. Evening
cally. type is considered to be a risk factor for psychiatric disorders and
Results.– Measures of pre and postoperative brain activity show a neurological soft signs (NSS) are prevalent in some psychiatric dis-
higher level of alpha waves as the study proceeds. Additionally, pre orders like schizophrenia.
and post operative salivary cortisol levels have decreased through- Objectives: There is no study investigating the lifestyle and neuro-
out the trial. Qualitative feedback gained from the participants logical symptoms in individuals with no psychiatric disorder. The
suggests increased capacity to reduce distress. present study aimed to reveal the relationship between biological
Conclusions.– While results still await formal analysis, early results rhythm differences and NSS.
suggest that neurobiofeedback meditation can enhance doctor Methods.– 180 healthy volunteered undergraduate students
physiological and subjective well-being as well as performance. that have no neurological or psychiatric disorders and use
Formal results will be ready by December 2018. It is hoped that no psychotropic medication were recruited and Morningness-
future studies will build on these results and utilize biofeedback Eveningness Questionnaire (MEQ), Symptom Checklist-90-Revised
meditation over a longer period. (SCL-90-R) were administered. 80 intermediate type were excluded
Disclosure of interest.– The authors have not supplied a conflict of and 50 morning type with 50 evening type participants were
interest statement. included in the study. NSS of the participants were examined by
a psychiatric researcher.
Results.– The mean NSS total scores were 0.12 in the evening group
E-PP0575 and 0.14 in the morning type group. There was no statistically sig-
Catatonia and neuroleptic malignant nificant difference between the morning and evening types among
total NSS scores and subscales of combining of sensory perceptions,
syndrome: independent entities or
motor coordination, sequencing of motor movements. The anger
two disorders of the same spectrum? and somatization subscale scores of SCL-90-R were significantly
M. Araújo1* , F. Caetano1 , A. Samouco2 , A. Norton1 higher in the evening type group. There was a positive correla-
1 Hospital Magalhães Lemos, Psychiatry, Porto, Portugal; 2 Unidade tion between the somatization, depression, obsessive-compulsive
Local de Saúde do Norte Alentejano, Psychiatry, Portalegre, Portugal disorder, interpersonal sensitivity subscale scores and the motor
symptoms subscale of NSS.
Conclusions.– In the present study, chronotype was found to be endophenotype and for understanding the association between
associated with psychopathological symptoms, however not with various socio demographic and illness variables (like age, gen-
NSS. The relationship between chronotype and biological features der, duration of illness, handedness) between the subsets of
such as NSS should be further studied in different samples. schizophrenic patients.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– 30 patients with positive symptoms of schizophrenia,
interest statement. 30 schizophrenic patients with negative symptoms and 60 age and
sex matched controls were recruited from Psychiatry OPD and IPD
from a tertiary care rural hospital. The Waldrop Minor Congeni-
E-PP0577 tal Anomaly Scale (Waldrop and Halverson 1971) was applied for
Neurobehavioural effects of acute and recording the scores of Minor Physical Anomalies.
repeated administrations of Results.– The Minor Physical Anomaly (MPA) scores were signifi-
cantly more in positive as well as negative subsets of schizophrenic
sub-psychotomimetic dose of
patients with a statistical difference of (p < 0.0001) as compared
ketamine in mice to healthy controls. However there was no statistical significant
S. Atunwa1* , O. Adeyemi2 , A. Owolabi2 difference in MPA scores between the two groups of schizophrenics.
1 University of Ilorin, Pharmacology and Toxicology, Ilorin, Nigeria; 2 Conclusions.– Increased MPA scores in schizophrenic patients in
Obafemi Awolowo University, Pharmacology, Ile-Ife, Nigeria comparison to controls advocates that Minor Physical Anomalies
may be considered as a useful Neuroendophenotypic marker for
Background and aims.– Innovations, legal and financial challenges establishing an etiopathogenesis in the schizophrenic disease pro-
currently facing the discovery and development of new thera- cess.
peutic agents have necessitated the need for the adoption of Disclosure of interest.– The authors have not supplied a conflict of
the concept of ‘drug re-positioning’. Recent studies have shown interest statement.
that sub-anaesthetic doses of ketamine may induce analgesia,
but its psychotomimetic side effects have called for caution. This
E-PP0579
study therefore, explored a possible sub-psychotomimetic dose of
ketamine (SPDK) and assessed the neurobehavioural effects of its Application of movement-tracing
acute and repeated administrations in mice. technology for cognitive coaching in
Methods.– Mice of either sex weighing 18–25 g were randomly depressed and schizophrenic patients
selected into two major groups: A and B. Group A were distributed during and after ECT (case report)
into seven sub-groups (n = 12) and assessed for stereotyped hor- M. Bazhmin1* , A. Peled2 , R. Geva2 , A. Grinshpoon2
izontal locomotion using the open field test while Group B were 1 Israel Technology University Technion, Shaar Menashe, Shaar
allotted into two sub-groups: I and II, and used in the assessment Menashe, Israel; 2 Technion, Shaar Menashe, Shaar Menashe, Israel
of neurobehavioral effects of acute and repeated administrations * Corresponding author.
of SPDK using elevated plus-maze (EPM) and Y-maze respectively.
Data were presented as Mean ± SEM and analyzed using ANOVA Background and aims.– Introduction In this study are investigating
followed by Student-Newman-Keuls test with p < 0.05. efficacy of cognitive enhancement and clinical improvement due
Results.– It was shown that 1 mg/kg ketamine is devoid of to coupled synchronized brain plasticity-inducing-stimulation and
psychotomimetic side effects, thus chosen as a SPDK. Acute a new technology for intensive-cognitive-training, in patients with
administration of SPDK did not significantly impair memory of severe debilitating psychiatric disorders.
mice in both EPM and Y-maze models whereas, its repeated Objectives: Our objective was to use a movement-tracing technol-
administrations showed comparable results to the group admin- ogy for cognitive improvement in depressed and schizophrenic
istered scopolamine, thus suggesting that the memory impairment patients during and after plasticity-stimulating treatment (ECT) in
induced by ketamine is time and dose-dependent. small group of two patients in comparison with control-group of
Conclusions.– Ketamine 1 mg/kg is devoid of psychotomimetic side two healthy controls).
effects and that its acute but not repeated administrations did not Methods.– We examined patients in a closed psychiatry ward, who
impair memory function in mice. werecandidates for ECT treatment. Our aim was to examine the
Disclosure of interest.– The authors have not supplied a conflict of cognitive tasks which have most robust improvement potential
interest statement. for patients. We then investigated ECT brain stimulation coupled
with cognitive training and tested their cognitive improvement in
comparison with healthy people (control-group).
E-PP0578 Results.– Results show significant improvement of different cogni-
Minor physical anomalies in positive tive functions as seen from the Figure 1.
versus negative symptom patients of Also, reaction delay improved in this patient (Figure 2).
schizophrenia
S. Babhulkar
BJ Govt Medical College, Psychiatry, Pune, India

Background.– Minor physical anomalies (MPAs) has been described
by Jones (1988)78 as “unusual morphologic features that are of no
serious medical or cosmetic consequences to the patient. The value
of their diagnosis is that they may serve as indicators of altered Figure 1. Training progress – AN10.
morphogenesis in a general sense or may constitute valuable clues
in the diagnosis of a specific pattern of malformation”.
Aims.– This study was designed to examine the Minor Physical
Anomalies in positive versus negative subsets of schizophrenic
patients and identify the degree of abnormalities of this specific
E-PP0581
The role of CADM2 RS9841829 in
academic performance
M. Bonea1* , M. Farcas2 , C.I. Coroama3 , R.A. Popp2 , I.V. Miclutia1
1 Iuliu Hat, ieganu University of Medicine and Pharmacy, Psychiatry,
Cluj-Napoca, Romania; 2 Iuliu Hat, ieganu University of Medicine and
Pharmacy, Medical Genetics, Cluj-Napoca, Romania; 3 Iuliu
Hat, ieganu University of Medicine and Pharmacy, Student,
Cluj-Napoca, Romania
Figure 2. Reaction delay – AN10. * Corresponding author.
Conclusions.– Conclusions Treatment response in severe psychiatric

patients is often insufficient. Augmentation of treatment results Background and aims.–
is warranted in the treatment of such psychiatric patients. Thus Introduction.– CADM2 (synaptic cell adhesion molecule 2) gene on
evidence of plasticity-induction cognitive-exercise improvements chromosome 3 was found to play a part in information processing
is significant for improved treatment for these patients. speed. Due to the involvement in executive functioning, polymor-
Disclosure of interest.– The authors have not supplied a conflict of phisms in CADM2 influence academic performance. So far, the G
interest statement. allele of rs9841829 was correlated with alcohol dependence and
risk-taking behavior.
Objectives.– To assess the role of rs9841829 in educational achieve-
E-PP0580 ment.
Mild cognitive impairment in patients Methods.– 201 subjects, divided in 3 gender-matched groups (pri-
with epilepsy mary school-no degree, high-school and university degrees) were
V. Korostiy1 , I. Blazhina2* included in the study, 159 patients admitted for alcohol use disor-
1 kharkiv National Medical University, Psychiatry, Narcology and der and major depression disorder to the Psychiatry Department of
Medical Psychology, Kharkiv, Ukraine; 2 Bucovina State Medical the Cluj County Emergency Hospital, Romania and 42 medical stu-
University, Department of Nervous Diseases, Psychiatry and Medical dents at the University of Medicine and Pharmacy in Cluj-Napoca,
Psychology, Chernivci, Ukraine Romania. All patients signed an informed consent form. A TaqMan
* Corresponding author. genotyping assay was used for genotyping through real time PCR.
We assessed both the dominant and the recessive transmission
Background and aims.– The most common clinical manifestations models.
of psychiatric disorders with epilepsy are depressive, anxiety, cog- Results.– Regarding the recessive transmission model, there was a
nitive impairment and psychotic disorders. Cognitive impairments significant statistical difference in the frequency of the G allele of
of varying degrees have a significant effect on the functioning of the rs9841829 between the no degree and the university degree
patients, their socialization, and the level of disability. The study groups (OR = 2.31, p = 0.03, CI = 1.13–4.63). We did not find signif-
and correction of cognitive impairment at the add-on stage has a icant statistical differences neither between the no degree group
significant prophylactic value. and the high-school degree group (OR = 1.92, p = 0.1 CI = 0.93–3.87)
Methods.– We studied the features of clinical and psychopatholog- nor between the high-school and the university degree groups
ical manifestations in patients suffering from epilepsy and having (OR = 0.83, p = 0.72, CI = 0.42–1.61).
cognitive impairment of mild to moderate severity. The study was Conclusions.– Academic performance is a complex trait, influenced
attended by 52 patients (23 men and 29 women) who were inpa- by multiple genetic and environmental factors. The present study
tient or outpatient care. The following psychodiagnostic techniques found a possible association between the G allele of the rs8941829
were used: the test of 10 words of Luria, the MOCA test, the Mün- polymorphism of the CADM2 gene and difficulties in obtaining a
sterberg test, the quality of life scale, the Thomas test, the Hamilton higher education.
scale of depression and anxiety. Disclosure of interest.– The authors have not supplied a conflict of
Results.– As a result of the study, decreased memory and attention interest statement.
was observed in all patients, 41% of the subjects showed symp-
toms of anxiety and depression, a considerable part of patients -
65% - unexpectedly highly subjectively estimated the quality of E-PP0582
life, with signs of cognitive decline and objectively lowered levels No association between RS1260326
of functioning. All patients showed an interest in further non- and depression
pharmacological rehabilitation methods. M. Bonea1* , M. Farcas2 , C.I. Coroama3 , R.A. Popp2 , I.V. Miclutia1
Conclusions.– The results of the conducted research indicate the 1 Iuliu Hat, ieganu University of Medicine and Pharmacy, Psychiatry,
need for further study of the features of nonemetrical cognitive Cluj-Napoca, Romania; 2 Iuliu Hat, ieganu University of Medicine and
disorders in epilepsy and the development and implementation of Pharmacy, Medical Genetics, Cluj-Napoca, Romania; 3 Iuliu
training aimed at improving cognitive function and preventing the Hat, ieganu University of Medicine and Pharmacy, Student,
progression of cognitive impairment. Cluj-Napoca, Romania
interest statement.
Introduction.– The single-nucleotide polymorphism rs1260326 of
the glucokinase regulator gene (GCKR) on chromosome 2 was
linked to numerous metabolic markers including C-reactive pro-
tein (CRP) levels as well as several psychiatric conditions such as
alcohol dependence and bipolar disorder. High levels of CRP and
inflammation were correlated with depression.
Objectives.– To assess the association between rs1260326 and
major depressive disorder.
Methods.– We included 188 patients admitted to the Psychiatry
Department of Cluj County Emergency Hospital, Romania dur-
ing May 2017–May 2018 with a diagnosis of a major depressive E-PP0584

episode or alcohol use disorder (AUD). The patients were divided How to explore unconcious
in 2 equal age, gender-matched groups (I-depression, II-AUD with- decision-making in schizophrenia?
out depression, 94 subjects each, 74.4% male, with an average age
of 51.9 years). The affective symptoms were assessed with the
Reinforcement learning,
Hamilton Depression Rating Scale, 8 points being the threshold for mathematical computational models
depression. Real time PCR with a TaqMan genotyping assay was and artificial neural networks are
performed. We used Fisher exact test with GraphPad to evaluate joining the game
the dominant and recessive transmission models. All the patients D. Frydecka1* , T.A. Bielawski1 , J. Drapala2 , E. Klosinska1 , P.
agreed to sign the consent form and the study was approved by the Piotrowski1 , K. Kotowicz1 , J. Rymaszewska1 , B. Misiak3
Ethics Committee of the University of Medicine and Pharmacy in 1 Wroclaw Medical University, Psychiatry, Wrocław, Poland; 2
Cluj-Napoca. Wroclaw University of Technology, Institute of Computer Science,
Results.– Genotype frequencies in both groups were in agreement Wroclaw, Poland; 3 Wroclaw Medical University, Genetics, Wrocław,
with Hardy–Weinberg equilibrium. We did not find significant sta- Poland
tistical differences in the frequency of rs1260326 neither for the * Corresponding author.
dominant (OR = 0.94, p = 0.99, CI = 0.48–1.84) nor for the recessive
model of transmission (OR = 0.85, p = 0.84, CI = 0.4–1.91). Background and aims.– Artificial neural networks are used in the
Conclusions.– In the present study there was no association between field of psychiatry due to capacity of capturing disruptions in neural
rs1260326 and depression. circuits among patients in comparison to healthy controls.
Disclosure of interest.– The authors have not supplied a conflict of Aims of this study were: (1) to create artificial neural network
interest statement. model that simulates the process of reinforcement learning; (2)
to find the most suitable mathematical model reflecting process of
reinforcement learning in schizophrenia patients and healthy; (3)
E-PP0583 to investigate differences in genotype distribution dopaminergic
GRIN2B gene polymorphism in neurotransmission in both groups
chronic ketamine users Methods.– We established artificial neural network model of inter-
N. Fan* , L. An, H. He, M. Zhang, Y. Zhou, Y. Ou action between 7 regions of the brain with suitable algorithms.
The Affiliated Brain Hospital of Guangzhou Medical University, We used Probabilistic Selection Task to test reinforcement learn-
Biological psychiatry laboratory, Guangdong, China ing. General cognitive functioning was assessed by test (RBANS).
* Corresponding author. We performed analysis of polymorphisms in genes related to rein-
forcement learning.
Background and aims.– Introduction: Increasing evidence indicates Results.– Schizophrenia patients performed worse than healthy
that the glutamatergic system, particularly the N-methyl-d- control in cognitive test (RBANS). Neural network model confirmed
aspartate (NMDA) receptor, has played an important role in the the importance of subcortical structures during reinforcement
rewarding effects of addictive drugs, and genetic polymorphisms learning. Two mathematical models -C-learning and Rescola-
in GRIN2B being associated with schizophrenia. Whether GRIN2B Wagner–were best fitted to individual learning preferences.
gene plays a role in vulnerability in ketamine use is unexplored. Schizophrenia patients performance differed from the control:
Objective.– Examined the allelic variants of the NMDA Receptor test-faze response of schizophrenia patients did not diverge from
2B (GRIN2B) in chronic ketamine users, analysed the association random, as if learning in the pre-test phase had not taken place.
between GRIN2B gene polymorphism and ketamine use conditions. Differences in distribution of DRD2 gene polymorphism between
Methods.– Four single nucleotide polymorphisms (SNPs) of GRIN2B, two groups were revealed, it confirms role of dopamine levels in
rs890, rs1806201, rs7301328 and rs1805502 were examined in 151 cognitive performance. Moreover, we report that polymorphism in
male chronic ketamine users and 80 control subjects using a real- DARP32 gene modulates value of instruction during reinforcement
®
time PCR with the TaqMan assay system. Clinical symptoms in learning from positive stimuli.
ketamine users were evaluated with the Positive and Negative Syn- Conclusions.– Differences in performance in reinforcement learn-
drome Scale (PANSS), Beck Depression Inventory (BDI) and the Beck ing between schizophrenia patients and healthy controls partially
Anxiety Inventory (BAI). can be contributed to the genetic polymorphism in dopaminergic
Results.– The genotype distribution of rs1806201 had significant neurotransmission.
difference between ketamine users and control subjects (p = 0.024), Disclosure of interest.– The authors have not supplied a conflict of
and the T allele frequency in ketamine users was higher than that interest statement.
in the control subjects (p = 0.043, OR = 1.489, 95%CI = 1.013∼2.189).
Ketamine users of genotype TT and CC of rs1806201 had ear-
lier onset of ketamine use than subjects of genotype TC (p < 0.05). E-PP0585
The dose of ketamine consumption per day of use was higher in Genetic background of confirmation
rs7301328 genotype GG than in those with CG in ketamine users bias and reinforcement learning in
(p = 0.026). The positive symptom score of PANSS was lower in schizophrenia
rs890 genotype AA than in those with genotype AC in ketamine D. Frydecka1* , T.A. Bielawski1 , J. Drapala2 , E. Klosinska1 , P.
users (p = 0.047). Piotrowski1 , K. Kotowicz1 , J. Rymaszewska1 , B. Misiak3
Conclusions.– Our results suggest that GRIN2B gene polymorphism 1 Wroclaw Medical University, Psychiatry, Wrocław, Poland; 2
may play a role in vulnerability in ketamine use. Wroclaw University of Technology, Institute of Computer Science,
Disclosure of interest.– The authors have not supplied a conflict of Wroclaw, Poland; 3 Wroclaw Medical University, Genetics, Wrocław,
interest statement. Poland
Background and aims.– Human learn directly through environ-

mental experience and indirectly through rules and instructions.
Behavioral research has shown that instructions control choices
that often lead to a confirmation bias. Thus, people behave in accor-
dance with contingencies, as they are described, rather than as they E-PP0587
are actually experienced. Study of correlations between
Our aims were to create a computational model accounting for
neuropsychological test data,
behavioral data of Instructional Probabilistic Selection (IPS) task
and to investigate differences in genetic polymorphisms related
electroencephalography analysis and
to dopaminergic neurotransmission that influence reinforcement the profile of cerebral perfusion
learning. tomoscintigraphy in Alzheimer’s
Methods.– We tested 60 patients with schizophrenia and 67 healthy disease
controls with IPS task. In this task, participants select between N. Farhat1 , A. Ghariani1* , S. Sakka1 , F. Hamza2 , H. Hachicha3 , O.
probabilistically reinforced stimuli, while being (incorrectly) told Hdiji1 , M. Damak1 , F. Guermazi2 , H. Masmoudi3 , C. Mhiri1
that a specific stimulus has the highest (or lowest) reinforce- 1 Habib Bourguiba Hospital and LR-12-SP-19, Neurology, sfax,
ment probability. We created a computational Instructed Learning Tunisia; 2 Habib Bourguiba Hospital, Nuclear Medicine, sfax, Tunisia;
Model that has two confirmation bias parameters that reflect 3 Habib Bourguiba Hospital, Immunolgy, sfax, Tunisia
the influence of top-down projections from prefrontal cortex * Corresponding author.
to striatum making the influence of instructed stimulus either
stronger (␣IA) or weaker (␣ID). We fitted behavioral data to the Background and aims.– Electrophoresphalography (EEG) shows a
model for all participants. We assessed genetic variants affecting renewed interest in Alzheimer’s disease (AD) after some studies
prefrontal (COMTrs4680) and striatal dopaminergic neurotrans- found significant correlations between the results found by new
mission (DRD2rs6277, DARP32rs907094). imaging techniques (single photon emission computed tomogra-
Results.– We revealed that DARP32 gene polymorphism modulates phy (SPECT), positron emission tomography (PET)) and EEG intake.
the significance of instructions in accordance to positive feed- Methods.– We conducted a prospective study of 10 patients fol-
back (␣IA) among schizophrenia patients (p = 0.015) and among lowed for Alzheimer’s disease over a 6 month period (from 1
healthy controls (p = 0.045). There were no significant influences January to 30 June, 2013). The objectives of our study were to study
in polymorphism of DRD2 nor COMT on either confirmation bias the appearance of EEG and brain scintigraphy in AD and to look for
parameters (p > 0.05). correlations between the results of the neuropsychological tests,
Conclusions.– The extent to which individual’s learning from gains the contribution of the EEG and the aspect of SEPCT.
is altered due to instructions is modulated by DARP32 gene poly- Results.– The average age of 71 years [53–82]. The stage of demen-
morphism that influences D1 receptor function in striatum. tia was determined according to the MMSE score. It was mild in 2
Disclosure of interest.– The authors have not supplied a conflict of patients, moderate in 6 patients and severe in 2 other patients. EEG
interest statement. showed a slowing of posterior basic rhythm in 7 patients. A lack of
antero-posterior differentiation was observed in 2 patients. SPECT
showed hypo-perfusion in the bilateral temporo-parietal associa-
E-PP0586 tive cortex in all patients with a different degree of hypo-perfusion
Clinical, scintigraphic and biomarker from one patient to another. The significance of the objective out-
profile of cerebrospinal fluid in come of the SPECT was correlated with the stage of severity of the
cognitive impairment and the appearance of the EEG.
degenerative dementia Conclusions.– The results of this study found correlations between
N. Farhat1 , A. Ghariani1* , S. Sakka1 , F. Hamza2 , H. Hachicha3 , O.
the severity of dementia, the degree of cortical hypo-perfusion,
Hdiji1 , M. Damak1 , F. Guermazi2 , H. Masmoudi3 , C. Mhiri1
1 Habib BOURGUIBA Hospital and LR-12-SP-19, Neurology, sfax, and the slowing of posterior basic rhythm in EEG. However, these
results deserve to be confirmed by other studies with larger and
Tunisia; 2 Habib BOURGUIBA Hospital, Nuclear medicine, sfax,
refined series of quantified EEG techniques.
Tunisia; 3 Habib BOURGUIBA Hospital, Immunology, sfax, Tunisia
interest statement.
Background and aims.– The diagnosis of degenerative dementia
(DD) is based on international clinical criteria. Single photon emis-
E-PP0588
sion computed tomography (SPECT) brain perfusion imaging and
CSF biomarkers (A␤(1-42) , T-tau and P-tau) as a diagnostic aid in An effect of znf804a and obstetrical
suspected DD. The aim of our work is to study the clinical, scinti- complications on the severity of
graphic and biomarker levels of CSF (A␤(1-42) , T-tau and P-tau) in symptoms in schizophrenia
DD. T. lezheiko, E. Krikova, N. Kolesina, V. Golimbet*
Methods.– We conducted a prospective study over a 6 month Mental Health Research Center, Clinical Genetics Laboratory,
period (January-June 2013), including patients followed for a DD. Moscow, Russia
All patients were hospitalized for 24 hours and had a SPECT HMPAO * Corresponding author.
Tc99m and usual dosage of 3 CSF biomarkers. Five of our patients
had a myocardial MIBG scintigraphy. Background and aims.– It is generally accepted that schizophrenia
Results.– We collected 40 patients (16 men and 24 women). The is caused by the interplay between genetic and environmental fac-
average age of these patients was 69 ± 11.78 years. For Alzheimer tors. However effects of gene X environment (G x E) interactions
disease (AD), the sensitivity and specificity of the assay of the three on course and outcome of the disease have not been studied so far.
biomarkers were 82% and 100%. An agreement between the results To explore for the first time G x E interactions on clinical charac-
of neuropsychological tests, the scintigraphic results and biomarker teristics of schizophrenia, we studied the ZNF804A polymorphism
profile was noted in 77.5% of cases. rs1344706 (A/G), a genome-wide supported risk variant of psy-
Conclusions.– In DD, converged data for some diagnostic tests chosis, and obstetrical complications (OC), a risk-modifying factor
(biomarker profile, SPECT and MIBG myocardial scintigraphy) are for psychiatric disorders.
necessary in the debutantes and atypical forms. Methods.– The sample included 369 patients with schizophrenia
Disclosure of interest.– The authors have not supplied a conflict of (203 women, mean age 29.7 ± 10, age at disease onset 21.6 ± 7.3). Of
interest statement. them, 111 patients had a history of at least one definite OC. Clinical
characteristics, including age at disease onset and symptom sever-
ity assessed with the PANSS, were compared by ZNF804A genotype
in the groups with- and without OC.
Results.– Patients with the risk genotype AA and OC had higher activation and expression in elderly could be determinant for neu-
scores on the subscale of general psychopathological symptoms roprotection process and good management of the amyloidogenic
compared to the carriers of the CC genotype without OC (p = 0.007). pathway. The objective was to analyze the methylation patterns
Conclusions.– The results demonstrated the additive effect of of a minimal promoter region of REST gene in a group of 21 sub-
ZNF804A rs1344706 and OC on symptom severity in schizophrenia. jects diagnosed with late-onset Alzheimer’s disease (LOAD) and a
The work was supported by the RFBR grant №17-29-02088. control group conformed by 20 elderly people cognitively healthy
Disclosure of interest.– The authors have not supplied a conflict of (EPCH).
interest statement. Methods.– Bisulfite treatment of isolated genomic DNA was made
and through pyrosequencing, the differences between methylation
patterns were established. The gene expression of this transcription
E-PP0589 factor in peripheral blood mononuclear cells were determined by
The interaction effect of crp real-time PCR.
polymorphism and season of birth on Results.– The group of patients with LOAD presented a general pat-
tern of hypermethylation of the studied sequence in coordination
the age at disease onset in patients
with hypomethylation of a specific CpG dinucleotide (3-CpG), while
with schizophrenia the EPCH group showed global hypomethylation with hyperme-
V. Golimbet1* , T. Lezheiko2 , D. Romanov2 , E. Krikova1 thylation of the 3-CpG dinucleotide. Relative gene expression was
1 Mental Health Research Center, Clinical genetics laboratory, significantly lower in patients with Alzheimer’s disease than in
Moscow, Russia; 2 I.M. Sechenov First Moscow State Medical those who were cognitively healthy (p = 0.001).
University, Psychiatry and Psychosomatics, Moscow, Russia Conclusions.– The epigenetic regulation of REST transcription is
coordinated by methylation and demethylation of specific sites in
Background and aims.– There is a substantial body of literature the sequence, causing the lack of expression of this factor in patients
demonstrating that winter season of birth (SOB) increases the risk with LOAD. In cognitively healthy patients, specific regulation of
of schizophrenia (SZ). It has been also shown that winter SOB the promoter REST region methylation promotes its expression and
impacts the level of inflammatory mediators. C-reactive protein neuroprotective effect.
(CRP), a commonly used biomarker of systemic inflammation, asso- Disclosure of interest.– The authors have not supplied a conflict of
ciates with SZ and disease course. The aim was to examine if the interest statement.
CRP polymorphism rs2794521 (-717A>G) and winter SOB confer
the risk of SZ or contribute to the severity of SZ course.
E-PP0591
Methods.– We studied 2418 patients with ICD-10 diagnosis of
schizophrenia and 1208 healthy controls (678 and 324, respec- GABRA2 gene as a predictor of
tively, were born in winter). PANSS was used to measure symptom benzodiazepine tranquilizer’s
severity. CRP genotypes were determined in 727 patients and 476 effectiveness in patients with alcohol
controls. withdrawal syndrome
Results.– Both SOB and CRP polymorphism were not associated D. Ivashchenko1* , M. Solov’eva G.2 , A. Kibitov O.2 , M. Zastrozhin
with SZ. There was no SOB X CRP interaction effect on the risk of S.3 , E. Bryun A.4 , D. Sychev A.5
schizophrenia though the higher frequency of GG genotype was 1 Russian Medical Academy of Continuous Professional Education,
observed in winter SOB compared to other seasons (p = 0.08) in the Department of Personalized Medicine, Moscow, Russia; 2 Serbsky
patient group. The ANCOVA with age and sex of patients as covari- National Medical Research Centre on Psychiatry and Addictions,
ates revealed no effect of genotype or SOB on SZ course. There was Molecular Genetics Lab, Moscow, Russia; 3 Moscow Research
the SOB X CRP effect on the age-at-onset (p = 0.009). Post hoc anal- Practical Center of Addiction medicine, Prophilaxy, Moscow, Russia; 4
ysis showed that in patients born in winter, mean age at onset Moscow Research Practical Center of Addiction medicine,
was younger for the GG genotype compared to the AA genotype Administration, Moscow, Russia; 5 Russian Medical Academy of
(p = 0.02). Continuous Professional Education, Department of Clinical
Conclusions.– This finding corroborates with our previous results pharmacology and therapeutics, Moscow, Russia
that GG genotype was associated with higher schizotypal traits * Corresponding author.
in the general population (Alfimova et al., 2017). This work was
supported by RFBR grant N 17-29-02088. Background and aims.– Alfa-subunits of GABA-receptors in CNS is
Disclosure of interest.– The authors have not supplied a conflict of constantly included into domain. So, there were observed strong
interest statement. effects of genetic-determined changes in receptor’s functioning due
to alfa-2 subunit gene – GABR2A. Benzodiazepines are common
ligands of GABA-receptors. Consequently, their effectiveness might
E-PP0590 be altered by genetic polymorphisms of GABR2A.
DNA methylation of re-1silencing Aim.– To evaluate associations of GABR2A rs279858 and rs567926
transcription factor in late-onset polymophisms with effectiveness of benzodiazepine tranquilizer
in patients with alcohol withdrawal syndrome.
Alzheimer’s disease patients
Methods.– 102 male patients with non-comlicated alcohol with-
I. Gonzalez-Mundo1* , A. Miliar-Garcia1 , M. Gomez Lopez1 , N.
drawal syndrome were involved into the study. During 6 days
Perez Vielma2
1 Escuela Superior de Medicina Instituto Politécnico Nacional, of dynamic observation each participant was prescribed benzodi-
azepine tranquilizer phenazepam. Blood samples were analyzed
Laboratorio de Biología Molecular, Mexico City, Mexico; 2 Centro
to detect GABR2A rs279858 (A > G) and rs567926 (C > T) poly-
Interdisciplinario de Ciencias de la Salud IPN, Biología Molecular,
morphisms by real-time polymerase chain reaction. Effectiveness
Mexico City, Mexico
* Corresponding author. of therapy was evaluated with Clinical Global Imression Scale –
Improvement (CGI-I) at 6th day of treatment. Data analysis was
Background and aims.– Late-Onset Alzheimer’s disease is the most performed with SPSS Statistics 21.0.
frequent cause of dementia in elderly adults, however, the deter- Results.– There was significant association of GABRA2 SNPs with
mining factors for its beginning are still unclear. The RE-1 silencing CGI-I values in patients at 6th day of treatment. Particularly, car-
transcription factor (REST) has been described as a gene whose riers of genotype rs279858 AA had Significant Improvement only
in 58.8% (n = 20) compared to AG heterozygous – 91.5% (n = 43), Disclosure of interest.– The authors have not supplied a conflict of
p = 0.028. That was interesting that GG homozygous patients were interest statement.
comparable with AA – Significant Improvement was noted in 23.8%
(n = 5). GABRA2A rs567926 also was associated with effective-
ness of treatment. Significant Improvement was observed in 57.6% E-PP0593
(n = 19) of TT homozygous, but for CT – 85.4% (n = 41) and CC – 80% Prevalence and distribution of
(n = 16), p = 0.045. single-gene and intragenic copy
Conclusions.– GABRA2 rs279858 AA and GABRA2A rs567926 TT
number variations in patients with
were associated with less improvement in patients with alcohol
withdrawal syndrome taking benzodiazepine tranquilizer. idiopathic intellectual disability and
Disclosure of interest.– The authors have not supplied a conflict of developmental delay
interest statement. A. Kashevarova1* , N. Skryabin2 , M. Lopatkina2 , E. Belyaeva2 , L.
Nazarenko3 , I. Lebedev1
1 Research Institute of Medical Genetics- Tomsk National Research
E-PP0592 Medical Center- Russian Academy of Sciences, Laboratory of

Telomere length and chronic stress in Cytogenetics, Tomsk, Russia; 2 Research Institute of Medical Genetics,
internalizing mental disorders among Tomsk National Research Medical Center, Russian Academy of
Sciences, Laboratory of Molecular Diagnostics, Tomsk, Russia; 3
HIV+ children and adolescents in Research Institute of Medical Genetics, Tomsk National Research
uganda Medical Center, Russian Academy of Sciences, Laboratory of
A. Kalungi1,2,3* , J. Womersley S3 , E. Kinyanda1,4,5,6 , M. Joloba Hereditary Pathology, Tomsk, Russia
Lutaakome7 , W. Ssembajjwe1 , R. Nsubuga8 , P. Kaleebu9 , M. * Corresponding author.
Kidd10 , S. Seedat3 , S. Hemmings M J3
1 MRC/UVRI and LSHTM Uganda Research Unit, Mental Health, Background and aims.– Intragenic CNVs were observed in unexpect-
Entebbe, Uganda; 2 Makerere University, Department of Immunology edly high fraction (9.8%) of individuals with diverse pathologies and
& Molecular Biology, Kampala, Uganda; 3 Stellenbosch University, clinically significant chromosomal variations (Truty et al., 2018). A
Department of Psychiatry, Cape Town, South Africa; 4 Butabika new class of single-gene or intragenic CNV appears, that remains
National Psychiatric Referral Hospital, Butabika, Kampala, Uganda; 5 Mendelian single-gene disorder due to one affected gene and also
London School of Hygiene & Tropical Medicine, Faculty of leads to a wide variety of symptoms in one patient as contigu-
Epidemiology & Population Health, London, United Kingdom; 6 ous gene syndromes. The study was aimed to improve diagnosis of
Makerere University, Department of Psychiatry, Kampala, Uganda; 7 intellectual disability, to map genes responsible for mental health.
Makerere University, School of Biomedical Sciences, Kampala, Methods.– aCGH with 60K Agilent, qPCR.
Uganda; 8 MRC/UVRI and LSHTM Uganda Research Unit, Data & Results.– 410 patients with intellectual disability and developmen-
Statistical Section, Entebbe, Uganda; 9 MRC/UVRI and LSHTM Uganda tal delay have been investigated using aCGH and 151 of them (37%)
Research Unit, Basic Sciences Programme, Entebbe, Uganda; 10 had CNVs of different size; among them 20 patients (13%) had
Stellenbosch University, Centre for Statistical Consultation, single-gene or intragenic CNVs. Eight of 20 CNVs were confirmed
Department of Statistics and Actuarial Sciences, Cape Town, South by q PCR and were shown to be de novo (1), maternal (5), paternal
Africa (2) in origin. The parents-carriers of the same CNVs were healthy.
* Corresponding author. There were also two sibs with identical del3p26.3 affecting sin-
gle CNTN6, for whom parental DNA was not able for the analysis.
Background and aims.– Internalizing mental disorders (IMDs) in The only single-gene CNV was dup3p26.3 (CNTN6, pat). The intra-
HIV+ children and adolescents are associated with impaired qual- genic CNVs were del11q22.3 (DDX10), del3p26.3 (sibs, CNTN6),
ity of life and non-adherence to anti-retroviral treatment. Shorter del10q21.3 (CTNNA3), del12p11.1 (SYT10, mat), del15q23 (THSD4),
telomere length (TL), a marker of biological aging has been asso- dup1q31.1 (PLA2G4A), del7q31.1 (two unrelated patients, IMMP2L,
ciated with IMDs. However, the nature of this association is yet to both deletions – mat), dup7q22.1 (COL26A1), dup2q23.1 (MBD5),
be elucidated. We aimed to determine the longitudinal association dup8q24.12 (SNTB1, dn), del3q13.31 (LSAMP, mat), dupXp11.4
between chronic stress and TL over a 12-month period. (TSPAN7), dup14q31.1 (DIO2), del1p33 (AGBL4), dup4q31.23
Methods.– The child and adolescent symptom inventory–V (CASI-V) (NR3C2), dup4q31.21 (GYPA), dup11q13.3 (FADD, mat).
assessed for any IMDs. Relative TL (RTL) was assessed in 368 chil- Conclusions.– Single-gene and intragenic CNVs narrow the small-
dren and adolescents with any IMD and 368 age- and sex-matched est overlapping region of contiguous gene syndromes and provide
controls using quantitative polymerase chain reaction. Hierarchical a novel key for mapping of developmentally significant genes for
cluster analysis was used to generate the different chronic stress human brain.
classes. Logistic regression analysis was used to model the asso- Disclosure of interest.– The authors have not supplied a conflict of
ciation between chronic stress and RTL, controlling for age and interest statement.
sex.
Results.– Participants with IMDs were found to have significantly
longer RTL compared to controls at baseline (p < 0.001) but not at E-PP0594
follow-up (p = 0.117). Though we observed a trend towards asso- Evaluation of hypermethylation and
ciation between increased chronic stress and longer baseline RTL
expression pattern of glutamate and
among cases and controls (p = 0.067), chronic stress did not mediate
the association between IMDs and longer baseline RTL. dopamine receptors genes in patients
We observed a significant decrease in RTL over 12 months with schizophrenia
(p < 0.001), a finding that remained significant when we analyzed D. Kordi Tamanda
cases and controls individually (p < 0.001). This change in RTL was Associate Professor of Molecular Genetics, Dept of Biology, University
not associated with chronic stress (p = 0.272). of Sistan and Baluchestan, Dept of Biology, ZAHEDAN, Iran
Conclusions.– Baseline RTL is longer in participants with IMDs than
controls. There is a significant attrition in RTL over a 12 month
Background and aims.– Schizophrenia (SCZ) is type of psychotic dis-
period which is not driven by either IMD or chronic stress.
orders that affect 1% of population. Dopamine and glutamate are
the major neurotransmitters in brain and their receptors are asso-
ciated with number of psychotic disorders such as schizophrenia. Conclusions.– Besides its demonstrated implication in SZ, the diver-
The aims of the present study were to analyze methylation and sity of C4 locus also seems to influence BD development
expression profile of dopamine and glutamate receptors genes in Disclosure of interest.– The authors have not supplied a conflict of
patients with SCZ. interest statement.
Methods.– Methylation-specific polymerase chain reaction (MS-
PCR) was used to estimate promoter hypermethylation of
dopamine and glutamate receptors genes on 81 isolated genomic E-PP0596
DNA, from peripheral blood of individuals with schizophrenia Genetic interaction between neuronal
and 71 healthy control subjects. In addition, real-time reverse nitric oxide synthase and serotonin
transcription- PCR was used to estimate mRNA levels in 34 blood
transporter on prepulse inhibition in
samples of healthy controls and cases.
Results.– Methylation of GRM2 and GRM5, highly increased the risk humans
of schizophrenia in comparison to reference unmethylated pat- R. Rovny1 , M. Marko1 , G. Repiska2 , G. Minarik3 , I. Riecansky1,4*
1 Slovak Academy of Sciences, Centre of Experimental Medicine,
tern [OR = 2.82, (1.05–7.75), p = 0.038], [OR = 12.09, (1.84–79.57),
p = 0.0001] respectively. Regarding the dopamine receptors genes, Bratislava, Slovak Republic; 2 Comenius University, Faculty of
Promoter methylation of DRD4 and DRD5 genes were statistically Medicine, Bratislava, Slovak Republic; 3 Comenius University, Faculty
different (p < 0.05) in cases when compared to healthy controls in of Natural Sciences, Bratislava, Slovak Republic; 4 University of
blood samples. Outcomes of expression analysis revealed statically, Vienna, Faculty of Psychology, Vienna, Austria
significant difference between cases (n = 17) and health controls
(n = 17) regarding relative genes expression of GRM2, GRM5 and Background and aims.– Prepulse inhibition (PPI) is a reduction of the
GRIA3, DRD2, DRD4 and DRD5 (p < 0.0001). startle reflex to a loud sound when it is preceded by a weaker non-
Conclusions.– To the best of our Knowledge, this is the first report startling stimulus. PPI is an operational measure of sensorimotor
which indicates the methylation status and expression profile of gating, an important endophenotype of neuropsychiatric disorders.
GRs and DRs genes with the risk of SCZ. These outcomes, suggesting Serotoninergic neurotransmission plays a role in the pathogenesis
more attention on effect of epigenetic variations in development of of mental illnesses. Serotonin transporter (5-HTT) is a membrane
SCZ in further investigations. transporter protein responsible for the reuptake of serotonin and
Disclosure of interest.– The authors have not supplied a conflict of its genetic variability is linked with susceptibility to several men-
interest statement. tal disorders. One well known polymorphic locus in the 5-HTT
gene is a tandem repeat in the promoter region (5-HTTLPR-VNTR),
which affects the transporter’s activity. We have previously demon-
E-PP0595
strated that PPI is associated with a polymorphism (Ex1f-VNTR)
The role of complement c4 structural in the neuronal nitric oxide synthase (NOS1), an enzyme catalyz-
components in South Indian bipolar ing the production of nitric oxide (NO). Since NO is involved in
disorder and schizophrenia the regulation of 5-HTT, we explored combined genetic effects of
C.M. Mariaselvam1,2* , V. Trebossen1 , A. Sundaresh1,2 , C. Manier1 , NOS1-Ex1f-VNTR and 5-HTTLPR-VNTR on PPI.
W. Boukouaci1 , A. Ben Chaaben1 , R. Krishnamoorthy1,3 , M. Methods.– PPI of the acoustic startle reflex as well as the geno-
Leboyer1,3,4 , V.S. Negi2 , R. Tamouza1,3,4 type of NOS1-Ex1f-VNTR and 5-HTTLPR-VNTR were assessed in 256
1 Inserm U955, Psychiatrie Translationnelle, Créteil, France; 2 healthy adults.
Jawaharlal Institute of Postgraduate Medical Education and Research, Results.– We found a statistically significant (p < .05) interaction
Clinical Immunology, Pondicherry, India; 3 Fondation Fondamental, between NOS1-Ex1f-VNTR and 5-HTTLPR-VNTR on PPI. Statisti-
Fondation Fondamental, Créteil, France; 4 AP-HP- Hôpitaux cally significant was also a main effect of NOS1-Ex1f-VNTR, but not
Universitaires Henri Mondor, Pôle de Psychiatrie, Créteil, France 5-HTTLPR-VNTR.
* Corresponding author. Conclusions.– These findings suggest that NOS1 and 5-HTT are
involved in the regulation of sensorimotor gating. The interplay
Background and aims.– Features of immune dysfunction is com- between nitrergic and serotoninergic signaling pathways may thus
monly observed in a significant subset of bipolar disorder (BD) and be of importance in the mental disorders characterized by gating
Schizophrenia (SZ) patients. The MHC resident C4 gene isoforms deficit, such as schizophrenia or obsessive-compulsive disorder.
(C4A and C4B), copy number and structural size variations (long Disclosure of interest.– The authors have not supplied a conflict of
C4L/short C4S based on presence/absence of HERV-K), influence the interest statement.
C4 protein expression and confer genetic risk for SZ likely through
altered synaptic pruning (1), further supported by the genetic asso-
ciation between C4 CNVs and neuropil contraction in brain regions E-PP0597
associated with schizophrenia (2). Contribution of polymorphic variants
To characterize the C4 CNV distribution in genetically overlapping
of MAO-A and MAO-B genes into
BD and SZ patients and healthy controls (HC) and to analyze poten-
tial associations with clinical characteristics. prolactin levels in patients with
Methods.– 96 BD, 62 SZ and 92 HC enrolled at Jawaharlal Institute schizophrenia
of Postgraduate Medical Education and Research (JIPMER), South A. Semke
India were included in the study. Digital Droplet PCR was used Mental Health Institute, Department of endogenous disorders, Tomsk,
to characterize the C4 CNVs. Chi square test was used to compare Russia
the distribution of C4 copy numbers between groups. Spearman’s
Background and aims.– Hyperprolactinemia is an increase in serum
Correlation was used for quantitative variables.
prolactin levels. Under antipsychotic therapy it develops due to
Results.– 39 different genotypes of C4 were identified. The geno-
antagonism with dopamine. In patients with schizophrenia under
types AL-AL-BL-BL were more frequent in SZ and BD while
antipsychotic therapy, hyperprolactinemia significantly reduces
AL-AL-BL-BS was more frequent in BD as compared to HC (p = 0.009,
the standard of living. That is why the definition of predisposition
0.005 & 0.009 respectively). The AL-AL-BL-BS genotype was signif-
to hyperprolactinemia is an important medical problem.
icantly higher in BD as compared to SZ. The C4AL was positively
Aim of this research is to study of the contribution of polymorphic
correlated with MADRS score and C4 total count with GAF scores
variants of MAO-A and MAO-B genes into prolactin levels under
in BD (P = < 0.05).
antipsychotic therapy in the Caucasian population of the Tomsk E-PP0599

Region. The complement C4 structural
Methods.– 476 Caucasian patients of the Tomsk Region were
diversity in bipolar disorder and
examined. DNA was isolated from peripheral blood leukocytes
by a standard phenol-chloroform method. The concentration of
schizophrenia
prolactin was measured by an enzyme immunoassay. For the geno- V. Trebossen1* , C.M. Mariaslevam1 , C. Manier1 , W. Boukouaci1 , A.
typing 2 SNPs were selected: rs6323 (MAO-A) and rs1799836 Ben Chaaben1 , N. Hamdani1,2,3 , C. Hebbache2 , J.R. Richard1 , R.
(MAO-B). Allelic variants were identified by the real-time PCR Krishnamoorthy3 , M. Leboyer1,2,3 , R. Tamouza1,2,3
1 Inserm U955, Psychiatrie Translationnelle, Créteil, France; 2 AP-HP
method using the SNP Genotyping Assay sets on the StepOnePlus
device (USA). For the statistical processing of data, the software Hôpitaux Universitaires Henri Mondor, Pôle de Psychiatrie, Créteil,
package Statistica 10.0 was used. Comparison of groups of patients France; 3 Fondation Fondamental, Fondation Fondamental, Créteil,
according to genotype was carried out with the use of the Kruskal- France
Wallis criterion.
Results.– Statistically significant differences (p = 0.0002) were found Background and aims.– Genetic and clinical overlaps between
between prolactin levels in the carriers of genotypes TT (20.47 Schizophrenia (SZ) and Bipolar disorder (BD) are remarkable.
(11.02; 43.62) ng/ml) and GT (37.52 (16.85; 74.30) ng/ml) of poly- Strong correlations between C4 copy number variations (CNVs)
morphic variant rs6323 (Figure 1). and SZ risk through gene rearrangements influencing the synap-
Conclusions.– Polymorphic variant rs6323 contributes to prolactin tic pruning were demonstrated (1). The C4 genetic diversity,
levels in patients with schizophrenia. represented by isoforms (C4A and C4B), CNVs and structural
Disclosure of interest.– The authors have not supplied a conflict of size variations (long C4L/short C4S forms according to pres-
interest statement. ence/absence of HERV-K), influences the C4 protein expression (2).
We analyze the distribution of C4 CNVs of BD and SZ patients com-
pared to healthy controls (HC) and we examined the relationship
E-PP0598
between the C4 CNVs and clinico-biological parameters.
Artificial intelligence in the Methods.– 190 BD subjects, 97 SZ subjects and 132 HC enrolled in
classification of epigenomic markers Créteil, France were included in the study. Digital Droplet PCR was
of schizophrenia used to characterize the C4 CNVs. The circulating serum levels of
K. Szanto 44 cytokines were quantified using electro-chemiluminescence.
King’s College London, GKT School of Medical Education, London, Results.– We identified 44 different structural forms of C4 gene.
United Kingdom The C4 genotypic analysis showed that the most frequent geno-
* Corresponding author. type, AL-AL-BL-BS, was less frequent in SZ patients as compared
to HC (p = 0.017). We also observed in SZ patients that (i) high
Background and aims.– Several studies have identified epigenetic copy number of some C4 structural forms are correlated with a
alterations as crucial effectors in psychiatric disorders, which seem high level of some circulating cytokines (p < 0.05) and (ii) high copy
to post- transcriptionally alter the gene expression The role how- number of C4B and C4BL isoforms are associated with high PANSS
ever of these modifications in specific psychiatric disorders remains and CGI scores (p < 0.05). Finally, we also found that patients with
unclear. Evidence suggests, that epigenetic mechanisms may be early-onset BD have a higher copy number of C4A (p < 0.001).
critical in our understanding of heritability and expression patterns Conclusions.– Our findings suggest that C4-mediated processes are
of schizophrenia, a highly disabling neuropsychiatric illness that is involved in the immune dysfunctions underlying SZ and BD.
marked by disordered thinking and behaviour. Disclosure of interest.– The authors have not supplied a conflict of
The aim of this review is to summarise machine learning meth- interest statement.
ods in other psychiatric illnesses, and to determine whether these
techniques could be useful in the diagnosis and treatment of
schizophrenia. E-PP0600
Methods.– A literature review was conducted using PubMed and Biomarkers of psychomotor events in
other databases in the topic of Machine learning and psychiatric schizophrenia spectrum disorders
disorders.
N. Zakharova1 , L. Bravve2 , D. Kutovoy2 , G. Kostyuk3 , N. Veiko4 , S.
Results.– There is good evidence to suggest that early interventions
Kostyuk4
can decrease severity and improve outcomes of schizophrenia. 1 State Healthcare Institution «Psychiatric Clinical Hospital 1 n. a.
Machine learning methods may be useful in early recognition of
N.A. Alekseev of Healthcare Department of Moscow, The educational
disease to provide better patient outcomes.
center, Moscow, Russia; 2 Psychiatric Clinical Hospital 1 n. a. N.A.
Conclusions.– Artificial intelligence in the form of Machine Learn-
Alekseev of Healthcare Department of Moscow, The educational
ing methods may be a useful tool in classifying and screening
center, Moscow, Russia; 3 Psychiatric Clinical Hospital 1 n. a. N.A.
gene-gene and gene-environment interactions in complex human
Alekseev of Healthcare Department of Moscow, Head Doctor,
multifactorial genes with good statistical significance. Machine
Moscow, Russia; 4 Research Centre for Medical Genetics, Molecular
learning methods are capable of assessing independent predictive
Biology, Moscow, Russia
effects concurrently and thus capture the interaction of epigenetic * Corresponding author.
alterations across all genes. This technique also determines which
expression changes are more significant in modulating the risk of Background and aims.– The change in the number of copies (CNV)
developing the disease thus may in the future lead to progress in of genes in schizophrenia has been extensively studied by psychia-
predicting who will go on to later develop schizophrenia. trists and molecular biologists in the world. The aim of the study -
Disclosure of interest.– The authors have not supplied a conflict of a typological differentiation of disorders depending on the severity
interest statement. of psychomotor disorders and the search for molecular correlations
by the liquid biopsy method.
Methods.– 100 patients from the Psychiatric Clinical Hospital 1 n. a.
N. A. Alekseev, from which 54 patients with paranoid psychosis and
46 observations with catatonic symptoms in exacerbation phase of
psychosis. A control group included 80 healthy people.
Schizophrenic patient’s blood samples and healthy controls to E-Poster Presentation: Guidelines -
determine CNV ribosomal DNA and free circulation of DNA from Guidance/Intellectual Disability
blood plasma.
The degree of symptoms was assessed by international psychome-
tric scales - PANSS, SAS, NGS-A, BFCRS. To determine the level of
biomarkers in the blood plasma, we used the methods of phenol E-PP0602
extraction and non-radioactive hybridization. Development of fully effective
Results.– In the catatonia group there were six times more points personalities and professionals having
compared to the paranoid group in accordance with BFCRS 24.4 can attitude proactive mind set by
vs. 3.8 (p < 0,01) There are more copies of ribosomal DNA in the
eliminating self-defeating behaviours
genomes of the schizophrenia group than in the control group. Cell-
free circulating DNA increases significantly in the schizophrenia using medium of education
group during an exacerbation, compared with health controls. The counselling parenting training
accumulation of rDNA in cell-free DNA increases significantly in the (teachers)
catatonic group compared with the health control. M. Ashraf1,2,3
Conclusions.– During our research, we obtained unique data that 1 The Guides, Research & HRD Personality - Jobs - Career - Skills
could help understand the etiopathogenesis in case of disorders of Development, Lahore, Pakistan; 2 My Life, Research & Guidance,
the schizophrenia spectrum. Lahore, Pakistan; 3 The Ultimate Solutions, Research & Psychological
Disclosure of interest.– The authors have not supplied a conflict of Treatment, Lahore, Pakistan
interest statement. Background and aims.– Elimination of Stress, Anxiety and Depres-
sion @ rate 25% to 35“% globally.
Procrastination – A Deadly “Self Defeating Habit”
E-PP0601 Reference my last article published in “EUROPEAN PSYCHIATRY
Pharmacogenetic testing of MDR1 JOURNAL” Procrastination, deadly habit, people know what needs
(C3435T) and cytochromes as a tool to to be done and when it needs to be done but mostly choose procras-
tinate; therefore students, professionals, parents, children. . .list is
increase efficacy of treatment with
on. . .suffers alot; result in low grade, setback in jobs, career, rela-
antipsychotics tions, unemployment and general overwhelming stress.
T. Zhiganova1 , T. Sergeeva2 Over last 20 years of studies on procrastination, it’s crystal clear
1 Saint Petersburg Psychoneurological Outpatient Clinic N 5- Saint procrastination damages state of mind by all means also directly
Petersburg- Russia, outpatient treatment, St. Petersburg, Russia; 2 linked to number of negative associations, such as guilt, fear, stress,
Saint Petersburg State University- Saint Petersburg- Russia, Medical anxiety, depression, irrational behaviours, low self-esteem, awfully
faculty, St. Petersburg, Russia neurological disorders.
Methods.– Warmth Welcome
Background and aims.– Treatment resistance (TR) to antipsychotics Listening and providing Solutions by all means
and antidepressants is the main reason of increased cost of treat- Education
ment and poor patient compliance. Therapeutical effect of a drug Counselling
depends on drug concentration in blood and brain. Main contribut- Training
ing factors affection drug concentration in blood and brain are Awareness Programs
activity of cytochrome system and p-glycoprotein (p-gp). One of Emotional Stability by using therapies, techniques and train-
the possible reasons of TR is genetically determined activity of those ing.....etc
systems. this will lead directly elimination of harmful stress, anxiety, depres-
The goal of the study was to evaluate genotype of the main proteins sion at highest levels; people will live lives they deserve by all
affecting pharmacokinetics of antipsychotics: MDR1 (C3435T), means.
CYP2D6, CYP1A2, and CYP2C19 genotypes in patients with poor In case, If needed, Micro-Financing and Aid.
response to the treatment with antipsychotics. Most importantly confidence, trust factor to being listened with
Methods.– 33 patients with TR underwent pharmacogenetic testing feelings/sense of not being alone.
of MDR1 (C3435T), CYP2D6, CYP1A2, and CYP2C19 performed in Results.– Fully Effective Personalities and Professionals have the
medical laboratory MedLab. 2 was used for statistical analysis. followings:
Results.– Frequency of T/T homozygotes of MDR1 (C3435T) allele, Confidence and Self Trust
coding synthesis of inactive p-gp, in TR patients was 68% to compare A pro-active and supportive personality instead of dependent.
to 30% occurred in Russian ethnic group (p = 0.0001, 2 = 11.58). A sense of confidence with Emotional Stablility
CYP1A2 *1A/*1A genotype found in 53% of TR patients as opposed to Awareness about their personality types
17% in Russian ethnic group (p = 0.0001, 2 = 20,86). No statistically Educational and Professional Road Map.
significant changes in CYP2D6 and CYP2C19 were found. Complete Soft & Hard Skills Set
Conclusions.– Decreased activity of p-gp coded by MDR1 (C3435T) Winning Mind Set
allele gene can be one of the contributing factors affecting unsuc- Can Attitude
cessful treatment with antipsychotics. Further investigation of Micro FinancingFinancial Aid. likewise list is on.....and on......
CYP1A2, and CYP2C19, CYP2D6 genotypes frequency should be per- Continuous guidance and support 24/7 round the clock 365 days.
formed to define their role in TR to antipsychotics Pharmacogenetic Conclusions.– Recommendation to adopt “PRO-ACTIVE
testing implementation in psychiatry can be useful tool to increase APPROACH”.
efficacy of treatment with antipsychotics. Its our choice now we need patients to spend billions or
Disclosure of interest.– The authors have not supplied a conflict of Fully Effective Personalities/Professionals Free from Self-defeating
interest statement. Behaviours “The Winners/Contributors Towards Society”
interest statement.
E-PP0603 Results.– Firstly, men were found to require higher doses of antipsy-
The particularities of treatment of the chotics to achieve the therapeutic response, while women exhibit
psychotic episodes in patients with more side effects to antipsychotics, Moreover in terms of ther-
apeutic response relation to gender, Olanzapine was found to
autism spectrum disorders in national have better outcome at lower doses in female patients, However
clinical guidelines women need a closer monitoring, therefore some solutions are sug-
J. Chihai, L. Boronin, I. Nastas gested, like switching to Risperidone in case of QT prolongation in
State University of Medicine and Pharmacy- “Nicolae Testemit, anu”- female patients, also in case of metabolic syndrome and hyperpro-
Chisinau- Republic of Moldova, Psychiatry- Narcology and Medical lactinemia, switching to Aripirazole is suggested to female patients,
Psychology Department, Chisinau, Moldova Another interesting solution is adding Aripirazole to an already set
efficient treatment to female patients, yet this needs more support-
ive studies.
Conclusions.– New treatment protocols of schizophrenia based on
Introduction.– It is well known that pharmacological interventions
gender should be suggested to guidelines.
are not recommended for the routine treatment of behavioural
problems in children and youth with behavioural disorders, oppo-
interest statement.
sitional defiant disorder and autism spectrum disorders. The world
psychiatric community has established that psychosocial interven-
tions shall be first-line interventions in case of behavioural changes E-PP0605
in people with ASD. At the same time, if psychosocial interventions
are not sufficient or are not a solution in case of serious states in
Korean guidelines for the treatment
ASD, psychotropic drugs are recommended. The article describes of panic disorder: initial and
the particularities of the use of neuroleptics in patients with TSA. maintenance treatment strategies for
Goal.– The goal of the research is to develop strategy of treatment the pharmacological treatment of
for ASD patients during the psychotic episodes. panic disorder
Methods.– We have studied the strategy of treatment for ASD, H.S. Suh1* , M.K. Kim2 , J.H. Lee3 , M. Gim4
using Pubmed, NICE, Medscape until 2018. Based on the system- 1 CHA University School of Medicine, CHA Gangnam Medical Center,
atic reviews, we summarized the authors’ conclusions drawn up Department of Psychiatry, Seoul, Republic of Korea; 2 CHA University
based on the neuroleptic treatment of patients with ASD. School of Medicine, Department of Psychiatry, Seoul, Republic of
Results.– Psychosocial interventions shall be first-line interventions Korea; 3 National Rehabilitation Center, Department of Psychiatry,
in ASD, but neuroleptics or a combination therapy may be used in Seoul, Republic of Korea; 4 Sanggye Paik Hospital, Inje University
case of changes in the mental state of children, adolescents and College of Medicine, Department of Psychiatry, Seoul, Republic of
adults with ASD. It is recommended to give priority to risperidone, Korea
and aripiprazole is considered as the second-line drug. The neu- * Corresponding author.
roleptic drug shall be prescribed in a minimum tolerated dose, with
a slow titration until a clinical effect is reached and the treatment Background and aims.– Korean guidelines for treatment of panic
should not exceed 6 weeks. disorder (PD) 2018 was developed. This study investigated the con-
Conclusions.– Evidences were adjusted to national context and sensus among Korean experts regarding initial and maintenance
according the results we elaborated the first national clinical guide- pharmacological treatment strategies for the patients with PD in
lines about treatment of children and adult with ASD. Korea.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– The development committee for Korean guidelines for
interest statement. the treatment of panic disorder developed questionnaires pertinent
to initial and maintenance treatment strategies for pharmacologi-
cal treatment of PD, based on recent treatment guidelines published
E-PP0604 by the American Psychiatric Association, the National Institute
Sex differences in the therapeutic for Clinical Excellence, and the Canadian Psychiatric Association.
response and side effects of Seventy-two experts in PD answered questionnaires. We classified
expert opinions into three categories, first, second, and third-line
antipyschotics in the treatment of
treatment strategies, by analyzing the 95% confidence interval.
schizophrenia Results.– Antidepressants, benzodiazepines and combined with
N. Kadim cognitive-behavioral therapy (CBT) were recommended as treat-
Maarif Casablanca, University Hospital IBN ROCHD, Casablanca, ments of choice (ToC), and first-line strategies for initial treatment
Morocco of PD. Escitalopram, paroxetine, sertraline, and venlafaxine were
preferred from among many anti-panic drugs. Mean starting dose
Background and aims.– Gender difference in the clinical aspects of anti-panic drugs for initial treatment of PD was relatively lower,
of schizophrenia is a well documented fact that was a source than that for other psychiatric illnesses such as major depressive
of studies for many authors in order to get closer to the patho- disorder. In the case of maintenance treatment of PD, antidepres-
logical mechanisme of the disease, this gender difference is also sants and CBT were selected as ToC and first-line strategies. Patients
evident in the patient’s response to antipsychotics. However, guide- were recommended typically to be examined every four weeks
lines do not take in consideration patient’s gender at molecule during treatment, to review effectiveness and side effects of the
choice and required dosages and side effects monitoring in antipsy- drug. The duration of maintenance pharmacological treatment was
chotic prescription, Therefore the aim of this review was to suggest recommended to be continued for one year or more.
considering gender in the treatment of schizophrenia for better Conclusions.– These results, which reflect the recent studies and
outcomes. clinical experiences, may provide the guideline about optimal med-
Methods.– The search was conducted systematically on Pubmed ication treatment strategies for PD.
using keywords: (sex difference), (schizophrenia), (antipsychotics), Disclosure of interest.– The authors have not supplied a conflict of
20 articles were chosen to be matching the aim of the review, Then interest statement.
were reviewed and synthesized in order to focus on the aim of the
study.
E-PP0606 were defined by intelligence quotient (IQ) score under 70, deficits
Off-label use of antipsychotics in the in two or more adaptive behaviours, and age of onset under 18. Psy-
French psychiatric hospital of Nancy chiatric disorders were identified according to the ICD-10. Logistic
J. Tournebize1* , C. Birklé1 , D. Dobre2 , V. Gibaja1 , J.P. Kahn1,3,4 regressions were used for data analyses.
1 CHRU de Nancy, Centre d’Evaluation et d’Information sur la Results.– The prevalence of psychiatric disorders in adults with ID
Pharmacodépendance-Addictovigilance CEIP-A, Nancy, France; 2 was 16.7%. The most prevalent type of psychiatric disorder was
Centre Psychothérapique de Nancy, Département de l’Information dementia. Older adults, females, being minorities, urban residents,
Médicale et l’UNité de recherche et d’Investigation Clinique, Nancy, being literate, low-income groups, and having severe ID, were asso-
France; 3 Université de Lorraine, Professeur de Psychiatrie, Nancy, ciated with elevated risk of psychiatric disorder among adults with
France; 4 Centre Psychothérapique de Nancy, Pôle de Psychiatrie et de ID. Compared with individuals without psychiatric disorders, those
Psychologie clinique, Nancy, France with comorbid psychiatric disorders were more likely to use med-
* Corresponding author. ical service and less likely to use rehabilitation service.
Conclusions.– The prevalence of psychiatric disorder in adults with
Background and aims.– Despite treatment guidelines recommend- ID was strikingly higher than that in the general population. Health
ing that second generation antipsychotics (SGAs) are preferable and service utilisation among Chinese adults with ID remained a big
should be used as monotherapy, available literature revealed use of challenge. This study informs further investigations regarding com-
first-generation APs (FGAs), polypharmacy, and use of APs at lower mon mental disorders among people with ID, and has implications
than recommended doses. In addition, off-label indications of APs for public health strategies and health policies to meet health ser-
are very common. Minimal data exist regarding AP off-label use in vice need for this population.
French psychiatric hospitals. Disclosure of interest.– The authors have not supplied a conflict of
The aim of this study was to investigate the frequency and the interest statement.
nature of APs off-label prescribing in a population of hospitalized
patients with psychiatric disorder.
Methods.– Retrospective cohort study utilizing the hospital data E-PP0608
base of Centre Psychothérapique de Nancy from Mars 01, 2017 Psychiatric symptoms, challenging
through Mars 03, 2017. Only patients with at least one AP prescrip- behaviour and access to psychiatric
tion were included. services among adults with
Results.– 129 patients were included. The majority of patients were
men (51%,44 ± 16 years). The SGAs (59%) were the most prescribed.
intellectual disability in Turkey
A. Gormez1 , A. Kurtulmuş2* , Z. Ince3 , P. Torun4 , O. Uysal5 , S. Citak1
Although the majority of patients (74%) received at least one AP, 1 Istanbul Medeniyet University, Psychiatry, Istanbul, Turkey; 2
23% were prescribed two APs, 3 patients three APs and 1 patients
Bezmialem Vakif University, Psychiatry, istanbul, Turkey; 3 Basak
four APs (3 SGAs +1 FGAs). In addition, 26% of patients had received
Special Education and Rehabilitation Center, Pschology, Istanbul,
APs for off-label indications such as reaction to severe stress
Turkey; 4 Bezmialem Vakif University, Public Health, Istanbul,
(14%), disorders due to psychoactive substance use (4%), depres-
Turkey; 5 Bezmialem Vakif University, Biostatistics, Istanbul, Turkey
sive episodes (n = 4) and specific personality disorders (n = 2). The * Corresponding author.
use of AP at lower than recommended doses was also observed
(17%). Background and aims.– Adults with Intellectual Disability (ID) expe-
Conclusions.– Off-label APs prescription was frequent. Patients rience mental health problems at least as often as the general
frequently received multiple APs and at doses below the recom- population. The aim of this study is to determine the prevalence and
mended guidelines for the management of psychotic disorders associated factors of psychiatric symptoms, challenging behaviors
without approval for use. When prescribing off-label use, pre- in adults with ID and to investigate the utilization of psychiatric
scribers should carefully evaluate risk/benefit ratio for the services and barriers experienced by people with ID or their carers.
individual patient [Ref 1]. Methods.– 771 people with ID were recruited through various set-
Reference.– tings. Psychiatric symptoms were evaluated by using PAS-ADD
[1] Tournebize, J. et al. 2018. Fundam. Clin. Pharmacol. (meeting checklist. Data on socio-demographic and other parameters were
abstract). collected through a purpose designed structured form.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The prevelance of psychiatric symptoms and challenging
interest statement. behaviours and associated factors were presented in Table 1 and
2. 31% of adults with ID were reported to have not been seen by
a psychiatrist during their life-time. Those who have had contact
E-PP0607
with psychiatric services reported some difficulties in the pro-
Adults with intellectual disabilities in cess as described in Table 3. Logistic regression analyses revealed
China: comorbid psychiatric disorder that higher level of support needed, having incontinence and chal-
and its association with health service lenging behavior and living in care homes were independently
associated with an increased likelihood of exhibiting psychiatric
utilisation
symptoms. Presence of psychiatric comorbidity and decreasing
P. He
level of verbal ability were also independently associated with an
Peking University, China Center for Health Development Studies,
increased likelihood of exhibiting challenging behaviors.
Beijing, China
Background and aims.– Adults with intellectual disabilities (ID)

often have multiple comorbidities. Psychiatric disorders in this
population have been poorly studied in developing countries. We
aimed to investigate the prevalence of psychiatric disorders in
adults with ID and whether comorbid psychiatric disorders were
associated with health service utilisation. Table 1. Psychiatric symptoms as dectected by PAS-ADD Checklist
Methods.– We obtained data from the Second National Sample Sur- and Challenging Behaviours*
vey on Disability, conducted in 31 provinces of China, and selected * Ns vary because of the missing data
a subsample of 13,631 adults aged 18 years and above with ID. ID

interest statement.
E-PP0610
Psychiatric and psychological
treatment for a woman affected by
turner syndrome, obsessive
compulsive disorder and intellectual
Table 2. Associations with Challenging Behaviours (CB) and Psychi-
disability: a good outcome
atric Symptoms (PS)
J. Santambrogio1,2* , E. di Giacomo2,3,4 , F. Colmegna3 , A. Bianco5 ,
M.O. Bertelli5 , A. Bentivegna2 , M. Clerici2,3
1 AS.FRA. Onlus, Casa San Paolo, Vedano al Lambro, Italy; 2 University
of Milano-Bicocca, Department of Medicine and Surgery, Monza,

Italy; 3 ASST–Monza, Psychiatric and Substance Dependence
Department, Monza, Italy; 4 Doctorate School of the University of
Table 3. Challenges experiences by those who have had contact with Milano-Bicocca, PhD program in Neuroscience, Monza, Italy; 5 San
psychiatric services within the past one year (48% of participants) Sebastiano Foundation, CREA Research and Clinical Center, Florence,
(n: 341) Italy
Conclusions.– Despite the high prevalence of mental health prob-
lems, it is evident that carers experience certain barriers to Background and aims.– The intellectual development of patients
accessing mental health care. This is the first study conducted on affected by Turner Syndrome (TS) has a normal range. Some authors
a large sample of adults with ID in Turkey and significant in this correlate mosaic karyotype TS to intellectual disability (ID). But
respect as an attempt at understanding mental health needs of small literature about correlations between TS and mental disor-
people with ID. ders can be found.
Disclosure of interest.– The authors have not supplied a conflict of To describe clinical and genetical features and treatment of a
interest statement. woman with TS associated with severe obsessive-compulsive dis-
order (OCD) and ID.
Methods.– A 22-year-old woman (S.) with mosaic karyotype TS 46,
E-PP0609 X, i (Xq)[40]\45, X[10], ID and OCD was referred in 2014 for a severe
Access and participation: what factors and debilitating form of OCD.
influence the provision and utilisation S. showed dwarfism, acoustic agnosia, amenorrhoea, pressured
of health care services by children speech, borderline ID (WAIS-R = 73) with disability pension. OCD
was shown since the age of 10. Compulsive cleaning (with a specific
with learning disabilities? issue about leaves) was the most pervasive symptom (confirmed
A. Rebowska
at SPAIDD-G) and compromised both her and her family quality of
Tees- Esk & Wear Valley NHS Trust, Westwood Centre,
life. She was prescribed Fluvoxamine 300 mg and Olanzapine 10 mg
Middlesbrough, United Kingdom
* Corresponding author. then shifted to Aripiprazole 10 mg due to drowsiness and weight
gain. Antipsychotic drug was due to the intensity of compulsions
Background and aims: Aims The aim of this literature review is to about leaves cleaning. Psychological support has been needed to
explore the range of factors that influence the degree of access to manage symptoms particularly for her low intellectual resources.
health care services by children and young people with learning Results.– Fluvoxamine + Aripiprazole treatment has been showing
disabilities. a good efficacy on OCD symptoms with no side effects. ID clearly
Background: Children with learning disabilities are at increased risk influences her treatment management needing a psychotherapic
of suffering from a wide range of health conditions comparing with approach. At Vineland Adaptive Behavior Scale (9/2018) she got
their peers. However recent reports by UK government as well good scores, over average for her ID level.
as independent charities working with children and young peo- Conclusions.– A combination of psychiatric treatment and psycho-
ple with learning disabilities demonstrated that they are at risk of logical support managed to reduce levels of symptoms and to find
poor health outcomes as a result of barriers preventing them from alternative behaviors to cope with the crisis.
accessing most appropriate services. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– Comprehensive searches were conducted in six interest statement.
databases. Articles were also obtained through review of refer-
ences, a search of the grey literature, and contacting experts in
the field. The inclusion criteria were for studies evaluating access
E-Poster Presentation: Mental Health Care/Sexual
to healthcare services, identification and communication of health
needs, organisational aspects impacting on access and utilisation, Medicine and Mental Health
staff attitudes where they impacted on access, barriers, discrimi-
nation in patients with intellectual disabilities age 0–18.
Results.– Barriers to access included problems with identification of E-PP0611
healthcare needs by carers and healthcare professionals, commu- Therapeutic milieu perceptions of
nication difficulties, the inadequacy of facilities, geographical and health care professionals and patients
physical barriers, organisational factors such as inflexible appoint- in psychiatric clinics in Ankara
ment times, attitudes and poor knowledge base of healthcare staff. S. Ozturk1 , F. Oz2
Conclusions.– The factors identified can serve as a guide for man- 1 Hacettepe University, Faculty of Nursing, Psychiatric Nursing,
agers and clinicians aiming to improve access to their healthcare Ankara, Turkey; 2 Near East University, Faculty of Nursing,
services for children and young people with intellectual disabilities. Department of Mental Health and Illness Nursing, Nicosia, Turkey
Background and aims.– Therapeutic milieu has great value in pro- tion theories. Knowledge management and expert panels were
viding holistic care which is one of the key element to be able to convened among 120 individuals including older people, geri-
improve mental health care. Unfortunately medical treatment has atric psychiatrists and psychogeriatric personnel to create relevant
dominantly been used in psychiatric clinics. It is aimed to determine concepts and items. A national meeting of 18 professional represen-
the therapeutic milieu perceptions of health care professionals and tatives of psychiatrists, psychogeriatric nurses, community leaders,
patients in psychiatric clinics. social workers, mental health promotion and prevention special-
Methods.– This descriptive research was carried out with 91 ists, older people and relatives was arranged to discuss, reviewed
patients (Pa) and 55 health care professionals (hcp) in psychiatric and revise the conceptual framework and items. Content validity
clinics in Ankara. The data were collected using The Ward Atmo- index (CVI) was tested among 5 psychogeriatric professionals. The
sphere Scale (WAS) and sociodemographic forms. measurement was pilot tested among 30 elderly without depres-
Results.– The lack of taking responsibility and drifting away the sion and cognitive deficits then Cronbach’s alpha was calculated.
social environment are stated common (%73) reason by the Results.– The SWE yielded 55 items in 9 dimensions, i.e., Enjoyment,
patients who indicated that the milieu is non therapeutic. Resolution, Fortitude, Congruence between desired and achieved
Nearly all of the subscales scores of WAS called involve- goals, Positive self-concept, Giving up authority, Mood tone, Rec-
ment (Pa:6.68 ± 2.46; hcp:4.62 ± 1.18), support (Pa:6.62 ± 2.42; onciliation with others, and Self-sufficiency. The number of items
hcp:5.47 ± 1.20), spontaneity (Pa:7.19 ± 2.32; hcp:4.41 ± 1.66), on each factor were 7, 8, 7, 8, 7, 3, 6, 5, and 4, respectively. The 4-
autonomy (Pa:5.88 ± 2.71; hcp:3.27 ± 1.19), practical orien- category Likert Scale responses ranged from 1 (strongly disagree)
tation (Pa:6.52 ± 2.49; hcp:4.67 ± 1.12), personal problem to 4 (strongly agree), with total scores of 55-220. The CVI was 0.944
orientation (Pa:6.99 ± 2.35; hcp:4.91 ± 1.11), anger and aggres- and Cronbach’s alpha was 0.896. It took about 20 minutes to com-
sion (Pa:6.47 ± 2.39; hcp:4.69 ± 1.49), programme clarity plete.
(Pa:7.14 ± 2.15; hcp: 5.85 ± 1.03), staff control (Pa:6.82 ± 2.26; Conclusions.– The SWE is a new self-administered life satisfaction
hcp:5.80 ± 1.59) are higher than the health care professionals’ tool for elderly people. It demonstrated excellent content validity
(p < 0.05). Although WAS scores of patients differs in education and reliability, and requires about 20 minutes to complete.
level, diagnosis and inhabited situations, WAS scores of health care Disclosure of interest.– The authors have not supplied a conflict of
professionals were statistically significant in gender, education interest statement.
level and profession (p < 0.05).
Conclusions.– Health care professionals perceived lower partic-
ipation, support, spontaneity, autonomy, practical orientation, E-PP0613
personal problem orientation, anger and aggression, program clar- Venous thromboembolism as a
ity and staff control. Paralel to these unwanted results, patients complication in psychiatric
defined non therapeutic milieu due to lack of taking responsibil-
inpatients: a case series and a proposal
ity and drifting away the social environment. It can be offered to
conduct qualitative studies to address deeper understanding of the of adapted prophylaxis algorithm
negative perceptions of both patients and health care professionals. M.T. Pons Cabrera1* , G. Anmella1 , M. Sagué1 , S. Gomes1 , S.
Disclosure of interest.– The authors have not supplied a conflict of Madero1 , A. Benabarre1 , J. Aibar2 , A. Gimenez1 , J.E. Pinzón1
1 Hospital Clínic de Barcelona, Psychiatry, Barcelona, Spain; 2
interest statement.
Hospital Clínic de Barcelona, Internal Medicine, Barcelona, Spain
E-PP0612
Background and aims.– Introduction: venous thromboembolism
Satisfaction and well-being of the (VTE) risk is high in psychiatric inpatients due to multiple spe-
elderly: a new tool for measuring life cific factors. Psychopathology and lack of awareness can lead to a
satisfaction among the aged delay in diagnosis and serious consequences. There is no validated
C. Phromsida1* , N. Wongpakaran2 , P. Udomratn3 , H. algorithm for VTE prevention for psychiatry inpatients.
Boonchareon4 , S.A. Phanprathum5 , T. Doungyota5 , P. Khaektao6 , Objective.– to study the characteristics of psychiatric inpatients
W. Muenmarerng7 , K. Hongchukiet8 , C. Tippinid8 , N. Chaichumni9 , diagnosed with VTE and to propose a prophylaxis algorithm.
N. Nualsuth9 , N. Puekkong9 , C. Supakul9 , J. Nuanmai10 , K. Methods.– Psychiatric inpatients diagnosed with VTE between
Sungprakhong9 , A. Koompai11 , K.S. Suvanchot9 , S. Kawanantakul9 January/2017–September/2018 in Hospital Clinic of Barcelona
1 Suansaranrom Hospital, Director office, Surat Thani, Thailand; 2 were included for analysis.
Chiang Mai University, Faculty of Medicine, Chiang Mai, Thailand; 3 Results.– Five patients were diagnosed with VTE. Two presented
Prince of Songkhla University, Faculty of Medicine, Songkhla, with pulmonary embolism. 100% were women with mobility
Thailand; 4 Southern Institute of Child and Adolescent Mental Health, reduction or other risk factors for VTE. Four were older than 60 and
Director Office, Surat Thani, Thailand; 5 Suansaranrom Hospital, diagnosed with affective disorders, three received antipsychotic
Nurse Office, Surat Thani, Thailand; 6 Suansaranrom Hospital, Nurse drugs, four were given antidepressants, and three underwent elec-
Office, Surat Thani, Thailand; 7 Suansaranrom Hospital, Nursing troconvulsive therapy. None was assessed for VTE risk nor received
Office, Surat Thani, Thailand; 8 Suansaranrom Hospital, Academic prophylactic treatment. The average latency between admission
Office, Surat Thani, Thailand; 9 Suansaranrom Hospital, Nursing and diagnosis was 11,2 days.
Office, Surat Thani, Thailand; 10 Suansaranrom Hospital, Social Conclusions.– Even though all patients had risk factors for VTE, no
Worker Office, Surat Thani, Thailand; 11 Suansaranrom Hospital, preventive measures were taken. This complication was associated
Psychologist Office, Surat Thani, Thailand with further morbidity, longer stays, and a high level of attention
* Corresponding author. required, leading to delayed recovery. The lack of validated proto-
cols for VTE prophylaxis that prioritize mental health issues makes
Background and aims.– detection more difficult and delays treatment. However, VTE is eas-
Introduction.– Life satisfaction measurements used among the Thai ily preventable with systematic risk assessment. Thus, we propose
elderly were translated from English, and were not initially devel- an algorithm based on previous examples, guidelines and scores
oped for the elderly. used for medical patients (Fig. 1).
Objective.– To develop the Satisfaction and Well-being of the Elderly
(SWE).
Methods.– An extensive literature review was conducted according
to aging, biological, psychological, sociological and life satisfac-
E-PP0615
Association of occupational stress
with health-related behaviours
among tunisian on shore oil workers
N. Rmadi* , N. Kotti, I. sallemi, I. feki, K. jmal hammemi, M. Larbi
masmoudi, M. hajjeji
University Hospital Hedi Chaker Sfax, Occupational Medicine, Sfax,
Tunisia
Background and aims.– Our study aimed to explore the relation-

ship of occupational stress and social support with health-related
behaviours of smoking and alcohol usage among Tunisian onshore
Figure 1. VTE: algorithm based on guidelines and scores used for oil workers.
medical patients. Methods.– we conducted a cross-sectional survey among 94
onshore oil installation workers of a Tunisian private oil company
Disclosure of interest.– The authors have not supplied a conflict of over a period of 3 months from 1st January to 31 March 2018. They
interest statement. were investigated with a self-administrated questionnaire about
socio-demographic characteristic and health-related behaviours.
Occupational stress and social support were evaluated with Job
E-PP0614
Content Questionnaire.
New models in reformed mental Results.– This cross sectional study included workers exclusively
health system in Bosnia and male with an average age of 41.17 years. The majority of employees
Herzegovina were married (72.6%). About half had a higher level of education.
G. Racetovic1* , S. Popovic2 , B. Rosic2 , S. Grujic-Timarac3 , M. An average of professional seniority was about 14.03 Years. Of 94
Latinovic4 workers, 33 (34.7%) were current smokers, 18 (18.9%) were cur-
1 Health Center-Community Mental Health Center Prijedor, rent drinkers. Job-strain and iso-strain were respectively noted in
Community Mental Health Center, Prijedor, Bosnia, Herzegovina; 2 72.3% and 38.3%. The analysis indicated that current smoking was
Health Center Prijedor, Health Center, Prijedor, Bosnia, Herzegovina; significantly associated with low social support with an OR = 3.3
3 Hospital “Dr. Mladen Stojanovic” Prijedor, Department for (IC95% [1.04–10.62]). Tobacco addiction was associated with iso-
Psychiatry, Prijedor, Bosnia, Herzegovina; 4 Ministry of Health and strain work with an OR = 3.6 (IC95% [1.05–12.7]).
Social Welfare of Republic of Srpska, Department for Hospital Care, Conclusions.– The findings suggest that psychosocial factors of occu-
Banja Luka, Bosnia, Herzegovina pational stress and social support at onshore oil work might affect
* Corresponding author. worker’s health-related behaviours in different ways.
Background and aims.– Starting on 2010, last mental health reform interest statement.
in Bosnia and Herzegovina (BH) had structured and community
based orientation to develop eaqual services in whole country. In
last eight years network of 71 community mental health centers E-PP0616
(CMHC) was established with building connections with other ser- Pilot study of burnout, depression and
vices and institutions in their communities. For the next four years
anxiety of GPS: work-place
implementation of established services as well as specific new ser-
vices will be main process in the Project of Mental Health (PMHBH) antecedents and consequences
supported by entities’ ministries of health and Swiss Government. I. Žukauskaitė1 , A. Šarskutė2* , G. Styraitė2 , J. Pečeliūnienė2
1 Vilnius University, Faculty of Philosophy, Vilnius, Lithuania; 2
Methods.– Comparing results of First and Second (2010–2018)
Phase of PMHBH and present main course of Third phase Vilnius University, Faculty of Medicine, Vilnius, Lithuania
(2018–2022).
Results.– As major results is important to highlight unified men-
Background and aims.– Burnout proportions among general practi-
tal health policies for next 5 years, 71 CMHC in BH, accreditation
tioners (GP) are rising rapidly. It has a negative effect on the physical
of most of CMHC, establishing occupational therapy, using case
and mental health.
management as main course in work with patients, collaborative
Objective.– To assess the relationships of GP’s burnout, anxiety,
activities with user organization and in local communities, and
depression with work-place antecedents and consequences.
establishing anti-stigma and social inclusion guidances in BH. In
Methods.– 46 GPs from six outpatient clinics took part in study.
the next four years focus will be on child and adolescent psychiatry
Burnout was assessed using the Shirom-Melamed burnout measure
in the community, external and clinical supervision of case man-
(SMBM) with physical fatigue, emotional exhaustion and cogni-
agement and occupational therapy, supporting changes in media
tive weariness subscales. Depression and anxiety was measured
relations and involvement of users in media and further social sup-
using the Hospital Anxiety and Depression Scale (HADS). Quality
port to users as well as new inputs in existing laws for further
of life, work satisfaction and work climate each were measured by
protection of people with mental disorders in BH.
10 point Likert type scale. GPs were asked about work conditions
Conclusions.– Model of structured community based treatment and
(working in the office alone or with others, work amount exceeding
rehabilitation in BH gave first results. Support of policy makers
full-time employment, GP’s work experience).
and strong involvement of the mental health professionals teams
Results.– Physical fatigue had significantnegative correlations with
together with users will continue.
life quality (r = −.551), work satisfaction (r = −.603) and work cli-
mate (r = −.410). Cognitive weariness had negative correlations
interest statement.
with life quality (r = −.307), work satisfaction (r = −.372) and work
experience (r = −.482). Emotional exhaustion was negatively cor-
related with work satisfaction (r = −.372) and work experience
(r = −.376). Correlations were found between depression and life
quality (r = −.551), work satisfaction (r = −.603) and work climate E-PP0618

(r = −.308). Anxiety was related with life quality (r = −.551), work Connection between the amount of
satisfaction (r = −.603) and work climate (r = −.375). Moreover
time spent by Russian teenagers on
lower anxiety level was among GPs who worked alone comparing
to those who worked in office with others (t(44) = −2.103, p = .045). the internet and their psychological
Conclusions.– Work experience, working alone and positive work well-being
climate are preventive factors for burnout and mental health. Y. Zinchenko, L. Shaigerova, A. Dolgikh, O. Almazova, R. Shilko* , O.
Burnout, depression and anxiety may impact life quality and work Vakhantseva
satisfaction. Therefore, proactive interventions should be taken. Lomonosov Moscow State University, Psychology, Moscow, Russia
interest statement.
Background and aims.– Global digitalization requires researchers
to determine the risks of the virtual socialization for the mental
E-PP0617 health and the psychological well-being of adolescents, them being
the most active users of the Internet space. We studied the impact
Towards an understanding of patients’ of time spent on the Internet by teenagers on their psychological
participation in the community-based well-being.
mental health services: a comparison Methods.– The study involved 491 adolescents from 15 to 17 years
of patients with treatment (Me = 16.1; SD = 0.9) from eleven subjects of the Russian Federation
discontinuation and other patients (196 male). Depending on the time spent on the Internet daily, the
N. Semenova1* , N. Shashkova2 , B. Kazakovtsev3 study participants were divided into three groups: (1) less than
1 Moscow Research Institute of Psychiatry MoH RF, Outpatient 2 hours a day – 31%; (2) from 2 to 4 hours a day – 40%; (3) more
Psychiatry, Moscow, Russia; 2 Moscow Research Institute of than 4 hours a day – 29%. Respondents were asked several questions
Psychiatry – Subsidiary The Serbsky Federal Research Center for about their current emotional and physical condition.
Psychiatry and Narcology, Outpatient Psychiatry, Moscow, Russia; 3 Results.–
Moscow Research Institute of Psychiatry – Subsidiary The Serbsky 1. Participants from Group 1 felt significantly less nervous or tense
Federal Research Center for Psychiatry and Narcology, Epidemiology, than teenagers from Group 2 (t = 2,865; p = 0,004) and from
Moscow, Russia Group 3 (t = 3,027; p = 0,003).
* Corresponding author. 2. Participants from Group 1 felt happy significantly more often
than teenagers from the group 2 (t = −2,063; p = 0,040).
Background and aims.– 3. Participants from the group 3 feel significantly less healthy than
Introduction.– The collaboration between hospital-based and teenagers from the group 1 (t = −3,148; p = 0,002) and from
community-based mental health services is of great importance. Group 2 (t = −2,025; p = 0,044).
Objectives.– To describe a review of the characteristics of patients Conclusions.– Thus, the more time teenagers spend on the Internet,
with treatment discontinuation (while referred from hospital- the more unhappy, nervous or tense, and the less healthy they feel.
based to community-based services) and patients who comply with The results demonstrate the negative impact of the abundance of
treatment. This study has a between – participant design. time spent on the Internet on the teenager’s perception of their
Methods.– A cohort of 162 patients with treatment discontinuation psychological well-being.
was compared with a cohort of 50 other patients with schizophre- The research was supported by the Russian Science Foundation,
nia. Comparisons were made on socio-demographic variables, time with the Grant 15-18-00109.
from the onset of schizophrenia, referral sources, and hospitaliza- Disclosure of interest.– The authors have not supplied a conflict of
tion rates. interest statement.
Results.– The characteristics of the two cohorts were compared.
Although there is no empirical evidence to support the claim, but
socio-demographic variables and referral sources could predict the E-PP0619
likelihood of a patient’s lack of follow-through. Data were com- Mental health and risks in
pared with data from existing studies on treatment adherence. organizational behavior
Certain key issues are addressed: the further need to re-evaluate F. Sultanova* , V.V. Barabanshchikova, A.A. Kachina, T.A. Zlokazova
the ‘medical model’ in the delivery of mental health care in a social Lomonosov Moscow State University, Psychology, Moscow, Russia
context; and the value of time conscious (not only time-limited) * Corresponding author.
interventions in the mental health care setting.
Conclusions.– The methodological weaknesses in such a study Background and aims.– This article presents results of the job
are outlined. While the results are not generalisable beyond this characteristics analyses among operating personnel of energy com-
sample, the implications are that consideration of the factors panies (Job Characteristics Theory, Hackman & Oldham, 1975).
underpinning the patients’ decision-making processes is desirable. The research aim was to analyze job characteristics related to the
Next steps: To gain a detailed understanding of the choice made increase in occupational stress and behavioral distortions. The sam-
by some patients and their families not to comply with treatment, ple included 5732 men (average age = 40.69).
using psychological theory to explore the motivation, perceived Methods.– The participants completed The Occupational Stress Sur-
consequences and decision-making processed involved. vey (Leonova, 2006), which identifies six stress indexes (perceived
Disclosure of interest.– The authors have not supplied a conflict of job conditions, job reward, acute and chronic stress manifestations,
interest statement. behavioral distortions and general stress index) and Russian ver-
sion of Job Diagnostic Survey (JDS).
Results.– Based on cluster analysis results three different groups
of employees were revealed according to general index of stress
and index of potential motivation. The group with high level of
stress and low potential motivation is characterized by acute and
chronic stress manifestations as well as behavioral risk factors
(risk behavior, impulsivity) and experienced low responsibility and
meaningfulness of work. The group with moderate stress and moti-
vation is characterized with moderate signs of acute and chronic Medicine, Iraklion, Greece; 3 University of Newcastle, Institute of
stress and moderate potential motivation. The third group is psy- Genetic Medicine, Newcastle, United Kingdom
chologically prosperous on both criteria - the indicators of the * Corresponding author.
psychological state (low or moderate stress) and potential moti-

vational growth. Background and aims.– Research conduct and care practices centred
Conclusions.– The results suggest that the strong need for personal on the person have received increased attention in recent years.
growth and individual ability to seek challenge regardless to a job There remains, however, a strong unmet need for a widely accepted
low in motivating potential are important psychological resources. person-centred-research-and-care (PCRC) framework, endorsed by
They reduces the risk of negative stress manifestations and con- all stakeholders, to allow for good communication, robust evidence
tributes to the well-being and reliability of the human factor. generation and optimal outcomes. The successful development and
Disclosure of interest.– The authors have not supplied a conflict of delivery of high quality social healthcare services encompasses
interest statement. an evidence-based, person-centred approach, including shared-
decision-making, evidence-informed personalised care planning
and self-management support, taking into consideration informa-
E-PP0620 tion asymmetry and potential disparities.
Predictors of recurrent referrals to We aimed to broker initial dialogue with stakeholders about their
preferences and needs, opportunities/synergies, and assessing will-
mental health treatment in secondary
ingness to actively support a collaborative participatory initiative
healthcare for the development, promotion and adoption of such a framework.
E. Talvitie* , T. Säämänen, E. Sailas Methods.– A series of national/international policymakers, regu-
Hospital district of Helsinki and Uusimaa, Hyvinkää Hospital Area, lators, academics, healthcare professionals and patient represen-
Hyvinkää, Finland tatives were asked to provide feedback on collaboration plans to
strengthen PCRC and examine the key elements that ought to drive
the generation, promotion and adoption of such a framework.
Background and aims.– With a growing number of referrals, sec-
Results.– Current issues that still prevent successful PCRC practices
ondary psychiatric care faces the pressures of providing acute and
were highlighted, i.e., poor training; limited knowledge/exchange
supportive help instead of more focused and evidence-based inter-
between stakeholders; lack of readily accessible information and
ventions. For public mental health services to be balanced most of
best practices, including tools to support local advocacy pro-
the psychiatric patients should be treated in primary care and the
grammes and to guide evidence-informed policy, diversity and
limited resources of secondary care to be focused on those in need.
inclusion schemes; lack of tools to monitor and evaluate outcomes
However, patients already discharged from secondary psychiatric
and impact of efforts related to PCRC practices; and lack of formal
care are often hastily re-referred. To focus the limited resources of
partnership between stakeholder groups in research and practice.
secondary care optimally research is needed on the predictors of
Conclusions.– A PCRC framework and a collaborative and participa-
re-referrals.
tory model are required to promote and adopt evidence-informed
The aim of the current study is to examine whether specific charac-
policymaking and lead to more resilience on person, system and
teristics of public sector secondary psychiatric treatment (length,
society levels.
type or intensity of treatment) and patient-related factors (diagno-
sis and the number of diagnoses) are associated with re-referrals in
interest statement.
Hyvinkää Hospital Area in Finland (population approx. 200 000).
Methods.– The sample consists of all referrals to secondary psychi-
atric care years 2016 and 2017 (1016 referrals, of which 230 (22.6%)
E-PP0622
had previous treatment) and 2017 (1275 referrals of which 260
(20.4%) had previous treatment) in Hyvinkää Hospital Area. Asso- Homophobia among muslim
ciations of previous treatment details and patients’ characteristics transgender men in Turkey: a
with re-referrals were examined using logistic regression. preliminary study
Results.– None of the treatment or patient-related factors were F. Alioglu* , A. Polat
associated with re-referrals among individuals discharged from Kocaeli University, Department of Psychiatry, Kocaeli, Turkey
earlier treatment. * Corresponding author.
Conclusions.– More research is needed on the predictors and use

of recurrent secondary psychiatric care. This information is needed Background and aims.– Turkey is a secular country with a
to establish clear criteria for prolonged and recurrent treatment in Muslim-majority population. In spite of the fact that psychiatric
secondary care and to enhance public sector psychiatric treatment interventions regarding gender dysphoria have been practiced for
further. many years in Turkey, no standard procedure have been followed-
Disclosure of interest.– The authors have not supplied a conflict of up yet. The purpose of this research is to examine the knowledge
interest statement. about the sexual orientation and gender identities, internalized
stigma and the attitudes toward lesbians and gay men on female to
male transgender individuals in Turkey.
E-PP0621 Methods.– A sociodemographic form, Gender Identity Self-Stigma
Development, promotion and Scale, The Attitudes toward Lesbians and Gay Men Scale, and Open
Ended LGBT Questtionaire were used to collect the data.
adoption of a person-centred research
Results.– A total of 12 FtM Muslim individuals are participated in
and care (PCRC) framework for this study. Mean age was 25,5. Non of the participants had com-
mental health: finding strength in pleted their sex reassignment surgery. The mean ATLG score is
collaboration between international 105.5 ± 40.5. Most of them answered the open ended questions
stakeholders which asked them about the definition of bisexuality or homosex-
M. Tinelli1* , E. Petelos2 , M. Ensini3 uality with saying that ‘it is a sin and an illness which can be cured
1London School of Economics, PSSRU, LONDON, United Kingdom; 2 with psychotherapy’. On the contrary, the question which asked
University of Creete, Clinic of Social and Family Medicine, Faculty of them the definition of transgender was answered by patients with
stating the exact meaning.
Conclusions.– Islam is clear in its prohibition of homosexual acts. Background and aims.– Sexuality and epilepsy have been intimately
Our findings about homophobia in transgender Muslim popula- linked since ancient times. Sexual dysfunction (SD) is frequently
tion are similiar to this reality. These people who are also victims reported by patients with epilepsy. However, it remains poorly
of discrimination are not immune to homophobia. While working studied in Tunisia.
with transgender patients we should be aware that their knowledge This study aims to assess the frequency of SD among a sample of
about sexual orientation could be very limited and their attitudes women with idiopathic epilepsy (IE) and to determine some asso-
toward homophobia can be challenging. ciated factors.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– A cross sectional study including 36 women with IE
interest statement. attending the institute of neurology of Tunis (Tunisia). Women
were non-menopausal, sexually active and living with partner for
more than 6 months. To assess the patients’ sexual function, we
E-PP0623 used the female sexual function index (FSFI). A total score below
Similarities and dissimilarities 26.55 defines SD.
between the motivational basis of Results.– The average age was 35 years. Twenty-six women (72.2%)
had SD. The incidence of SD was significantly higher in patients
problematic pornography use and
over the age of 40 (p = 0.003), inactive at work (p = 0.002), at low to
frequency of pornography use medium socio-economic level (p = 0.013), with longer duration of
B. Bőthe1* , I. Tóth-Király2 , G. Orosz3 , Z. Demetrovics1 epilepsy (p = 0.002), with nocturnal seizures (p = 0.006), occurring
1 Institute of Psychology- ELTE Eötvös Loránd University, Department more than once a month (p = 0.006), whose last seizure was less
of Clinical Psychology and Addiction, Budapest, Hungary; 2 Institute than 1 month (p = 0.008) and placed under dual or triple therapy
of Psychology, ELTE Eötvös Loránd University, Department of (p = 0.015). SD was also significantly greater in patients with men-
Personality and Health Psychology, Budapest, Hungary; 3 Stanford strual irregularities (p = 0.003), with longer duration of marriage
University, Department of Psychology, Stanford, USA (p = 0.002), and whose partners had sexual dysfunction (p = 0.047).
Conclusions.– There is a substantial impairment of sexual function-
Background and aims.– Problematic pornography use and frequency ing in Tunisian women with IE. This study demonstrates the need
of pornography use showed positive, but small-to-moderate asso- for increased awareness of the problem, better case identification,
ciations in previous studies indicating that these two aspects and improved seizure control.
of pornography use are related but yet may be considered as Disclosure of interest.– The authors have not supplied a conflict of
distinct domains of pornography use with potentially different interest statement.
antecedents and consequences. In the case of other behavioral
addictions and problematic online behaviors, different motiva-
E-PP0625
tional patterns emerged behind problematic use and frequency of
engaging in a given activity. However, this assumption was not Links between sexual dysfunction and
tested with respect to pornography use. The aim of the present anxiety and depression in women
study was to examine the similarities and dissimilarities in the with idiopathic epilepsy
motivational background of problematic pornography use and fre- W. Bouattour1* , L. Zouari1 , I. Ben Abdelaziz2 , S. Omri1 , N. Charfi1 ,
quency of pornography use. M. Maalej1 , R. Feki1 , J. Ben Thabet1 , M. Zouari2 , M. Maalej1
Methods.– Structural equation modeling (SEM) was employed 1 University Hospital Center Hedi Chaker, Department of Psychiatry
to examine the associations of pornography use motivations, C, Sfax, Tunisia; 2 National Institute Mongi Ben Hamida of Neurology,
problematic pornography use and pornography use frequency Neurology, Tunis, Tunisia
(N = 1,082; females = 537, 49.6%). * Corresponding author.
Results.– According to the results of SEM (CFI = .942, TLI = .935,

RMSEA = .064), problematic pornography use was positively and Background and aims.– Sexual dysfunction (SD) in women with
weakly related to sexual pleasure (ˇ = .09, p < .05), fantasy (ˇ = .12, epilepsy is a multifactorial problem with psychological, biological,
p < .01), boredom avoidance (ˇ = .14, p < .01) and emotional avoid- and social ramifications. Although several variables associated with
ance motivations (ˇ = .20, p < .01), whereas it was positively and the disease have been identified, some studies have raised the ques-
moderately related to stress reduction motivation (ˇ = .43, p < .01). tion of a possible influence of psychological factors, such as anxiety
Frequency of pornography use was positively and weakly related and depression, in defining or maintaining sexual difficulties in
to stress reduction (ˇ = .14, p < .05) and boredom avoidance moti- epilepsy.
vations (ˇ = .23, p < .01), and positively and moderately related to This study aims to evaluate the relationship between SD and anx-
sexual pleasure motivation (ˇ = .34, p < .01). iety and depression among a sample of women with idiopathic
Conclusions.– Our results suggest that it might be important to take epilepsy.
into account the motivational background of problematic pornog- Methods.– A cross sectional study including 36 women with idio-
raphy use and the frequency of pornography use to reveal more pathic epilepsy attending the institute of neurology of Tunis
fine-grained differences between intense and problematic users. (Tunisia). Women were non-menopausal, sexually active and living
Disclosure of interest.– The authors have not supplied a conflict of with partner for more than 6 months. To assess the patients’ sexual
interest statement. function, we used the female sexual function index (FSFI). A total
score below 26.55 defines SD. Depression and anxiety symptoms
were assessed by the Hospital Anxiety and Depression Scale.
E-PP0624 Results.– The average age was 35 years. The frequency of certain
Sexual dysfunction in women with depression was 22.2%, and 28% of patients had a certain anxiety
state. The frequency of SD was 72.2%. The prevalence of SD was
idiopathic epilepsy
significantly higher in patients with certain anxiety (p = 0,021) or
W. Bouattour1* , L. Zouari1 , I. Ben Abdelaziz2 , S. Omri1 , N. Charfi1 ,
depression (0,047). The different dimensions of sexual functioning
M. Maalej1 , R. Feki1 , J. Ben Thabet1 , M. Zouari2 , M. Maalej1
1 University hospital center Hedi Chaker, Department of Psychiatry C, (desire, arousal, lubrication, orgasm, satisfaction, pain) were nega-
tively correlated with the intensity of anxiety and depression. The
Sfax, Tunisia; 2 National Institute Mongi Ben Hamida of Neurology,
more women’s sexual functioning was preserved, the less anxious
Neurology, Tunis, Tunisia
* Corresponding author. and depressed they were.
Conclusions.– We conclude that psychological factors play an Methods.– The sample consisted of 119 HIV-infected men. 25 of
important role in the alteration of sexual behavior in epileptics them (21.0%, CSB-Men) met the criteria for the Compulsive Sex-
and that suitable attention must be given to the control of these ual Behavior Disorder (proposed for ICD-11). Experience in the use
variables. of illicit drugs and alcohol was assessed in a structured clinical
Disclosure of interest.– The authors have not supplied a conflict of interview.
interest statement. Results.– We found a high incidence of illicit drug use in both
CSB-Men and men without CSB: opiates consumption (24.0% and
27.7%, respectively), cannabinoid consumption (68.0% and 50.0%).
E-PP0626 The prevalence of psychostimulants use in CSB-Men was twice
Subjective quality of life of as high than in men without CSB (64.0% and 29.8%; p = 0.002;
transsexual people in different stages OR = 4.19; CI 95% 1.66–10.6). History of alcohol abuse was more
common in CSB-Men too (80.0% and 40.4%; p < 0.001; OR = 5.9; CI
of medical transition
95% 2.04-17.07). Alcohol abuse in CSB-Men was linked with the use
S. Kumchenko1 , A. Tkhostov2 , E. Rasskazova3 , A. Chepeliuk4*
1 of psychostimulants (R = 0.458; p = 0.021; 95% CI 0.077–0.72) and
Moscow State University, Clinical psychology, Moscow, Russia; 2
high frequency of commercial sex services use (R = 0.443; p = 0.026;
Moscow State University, I.M. Sechenov First Moscow State Medical
95% CI 0.058–0.71) – one of the significant risk factors for HIV infec-
University, Clinical psychology, Moscow, Russia; 3 Moscow State
tion.
University, Mental Health Research Center, Clinical psychology,
Conclusions.– The higher prevalence of psychostimulants and
Medical Psychology, Moscow, Russia; 4 Moscow State University,
alcohol abuse in HIV-infected men with CSB can be used as a
Clinical Psycholgy, Moscow, Russia
* Corresponding author. symptom-target for earlier diagnosis of CSBD, to improve the med-
ical and psychological assistance, and to prevent infection by other
Background and aims.– Effective dealing with transsexual people STIs.
should take into account and address subjective quality of life Disclosure of interest.– The authors have not supplied a conflict of
changes on different stages of medical transition. The aim was to interest statement.
compare of life satisfaction in transsexual people on different stages
of medical transition.
Methods.– 100 transsexual people in different genders and stages of E-PP0628
medical transition: 33 pre-operated Female-to-Male (FtM I), 15 FtM Sexual functioning of pateints
on a hormonal therapy (FtM II), 17 FtM after some surgical opera- suffering from mood disorders with
tions (FtM III); 7 pre-operated Male-to-Female-Transsexual (MtF I), possibly co-existing personality
11 MtF on a hormonal therapy (MtF II), 17 MtF after some surgical
disorders
operations (MtF III). They are compared with 100 cisgender peo- * , A. Szulc
˛
M. Debowska
ple (35% males). The participants filled Satisfaction With Life Scale
Faculty of Health Sciences of Medical University of Warsaw,
(Diener et al., 1985) and Gender Roles Male and Female scales from
Department of Psychiatry, Warsaw, Poland
Minnesota Multiphasic Personality Inventory – 2 (Butcher et al., * Corresponding author.
2001).
Results.– Transsexuals before medical transition are less satisfied Background and aims.– Sexuality is an integral part of the human
with their life than controls (mean = 15.2 for FtM and 14.6 for MtF functioning and the ability to satisfy sexual needs in harmony with
comparing to 21.4 for male and 22.0 female controls, p < .01). Tran- personal desires is one of the basic rights of any human being. Men-
sition is accompanied by different nonlinear trend in subjective tal disorders, which result in change in every aspect of life are highly
well-being (see graph): satisfaction increases in FtM II (20.3) but affecting one’s sexual life.
declined in FtM III (18.5). On the contrast MtF II have the lowest sat- The main aim of the proposed research was to characterize the
isfaction (10.9) while in MtF III satisfaction with life achieve normal model of sexual functioning of the patients with affective disorders
range (21.4). and verifying the role of the coexisting personality disorders.
Conclusions.– Results suggest that results of hormonal therapy sat- Methods.– 100 patients participated in the study (55 female and
isfy FtM but disappoint MtF. For surgical therapy there are vice 45 male) during the hospitalization due to depressive episode in
versa changes in satisfaction that should be expected by medical the course of the unipolar disorder (39), depressive episode in
staff. Research is supported by the Russian Foundation for Basic the course of the bipolar disorder (34 patients), manic episode in
Research, project No. 17-06-00849. the course of the bipolar disorder (27 patients). Following diag-
E-PP0627 nostic methods were used: structured clinical interview for the
The relationship between the illicit DSM-IV Axis II personality disorders, Mell Kratt scale of sexual
drugs use and alcohol abuse with needs, Female Sexual Function Index, International Index of Erectile
Function and two original questionnaires: Questionnaire for Sexual
compulsive sexual behavior in
Disfunctions and Questionnaire for Self Sexuality.
HIV-infected men Results.– A strong interplay between occurrence of affective dis-
E. Chumakov1,2* , Y. Ashenbrenner1,2 , N. Petrova1 orders and the intensity of sexual disorders have been found.
1 Saint-Petersburg State University, Department of Psychiatry and Occurence of the affective disorders significantly reduce the qual-
Addictions, Saint-Petersburg, Russia; 2 Saint-Petersburg Psychiatric ity of sexual functioning, both in terms of physiological and mental
Hospital №1 named after P.P. Kaschenko, Day in-patient Department, functioning.
Saint-Petersburg, Russia Conclusions.– Pharmacotherapy regulates the symptoms to some
extent, but may cause adverse effects. The coexistence of per-
Background and aims.– Compulsive Sexual Behavior (CSB) is sonality disorders increases the risk of aggravation of the sexual
strongly associated with HIV risk-taking behavior including among disorders symptoms during the course of the affective disorder and
others sex while under the influence of drugs or alcohol. The char- makes it less susceptible to modification through pharmacother-
acteristics of the illegal drugs and alcohol consumption by patients apy.
with CSB in Russia remain insufficiently studied. Aims: to identify Disclosure of interest.– The authors have not supplied a conflict of
the relationship between the illicit drugs use and alcohol abuse interest statement.
with CSB in HIV-infected men.
E-PP0629 ejaculation in 59.3% and male hypoactive sexual desire disorder

Frigidity in patients with chronic in 55.6%. Almost of the women, have at least one sexual disorder,
dermatoses the more frequent were: Female sexual interest/arousal disorder
N. Dobaeva* , N. Kibrik (57.1%) and female orgasmic disorder (60.7%).
Moscow Research Institute of Psychiatry, Department of Sexology and Conclusions.– This study demonstrates the prevalence of sexual dis-
Therapy of Sexual Dysfunctions, Moscow, Russia orders among patients living with HIV. Sexual disorders must be
* Corresponding author. considered by clinician to reduce their negative impact on both
quality of life of patients and their behavior for prevention.
Background and aims.– Assessment of the effects of chronic der- Disclosure of interest.– The authors have not supplied a conflict of
matoses on sexual function is a topical issue. Underestimation of interest statement.
the psychosomatic and sexological status of these patients signifi-
cantly decreases effectiveness of treatment.
Identification of clinical variants of sexual dysfunction in patients E-PP0631
with chronic skin diseases using investigations commonly Self-inflicted penile amputation as an
employed in sexological practice. unusual case of attempted suicide
Materials and methods.– The study enrolled 98 patients suffer- M. Filip* , M. Łukasik, A. Orzechowska, M. Talarowska, P. Gałecki
ing from psoriasis and neurodermatitis, aged 18 to 40 years, who Medical University of Lodz, Department of Adult Psychiatry, Lodz,
underwent clinical-psychopathological, psychological, and sexo- Poland
logical evaluations. The DLQI and the SCORAD were utilized to * Corresponding author.
classify the skin conditions by severity.
Results.– Frigidity was observed in 33 subjects (33.7%): 19 of them Background and aims.– Genital self mutilation is a rare and a severe
male (57.6%) and 14 female (42.4%). These patients had decreased form of self-injurious behavior usually described in psychotic dis-
libido, lack of confidence in their sex appeal, reduction of sex- orders, with delusions and hallucinations. This phenomenon has
ual tension, coital anorgasmia, depressed moods, and asthenia. A been described in schizophrenia, affective psychosis, alcohol intox-
skin disease present from early childhood prevented correct sex- ication, and personality disorders. The first report of genital self
ual development during pubescence in most cases as a result of mutilation (GSM) was in 1901 by Strock. It has been ascribed to sex-
restricted contacts with peers, as well as due to affective disor- ual conflicts, body image distortions, internalized aggression, and
ders. Sex with the partner was viewed as an obligation that was suicidal intent. The present case genital self mutilation in a case of
either escaped or performed unwillingly, with a sense of internal alcohol withdrawal state complicated by delirium is reported.
tension. Psychiatric disorders were detected in this study group: Methods.– A 32 year old divorced male presented with self penile
51.5% of these patients had a combined anxiety and depression amputation of with a sharp blade. The person was under the influ-
disorder, while dysthymia and hypochondriasis were practically ence of alcohol at few days before doing so. He reported a history
equally common in 48.5% of them. of substance use consisting of alcohol and psychoactive substances.
Conclusions.– Obtained data helped formulate a differentiated He also reported second person auditory hallucinations of a com-
approach to the psychopharmacological, psychotherapeutic, and manding type due to which he wanted to committed a suicide.
sexological correction of borderline psychiatric disorders and sex- Results.– We report herein a case of a traumatic penile amputation
ual disturbances that the described patient population has to and successful outcome of psychiatric treatment.
receive along with dermatological treatment. Conclusions.– Genital self-mutilation (GSM) is usually seen in indi-
Disclosure of interest.– The authors have not supplied a conflict of viduals suffering from psychotic illness and more so in response
interest statement. to a delusional process. Studies on GSM behavior have revealed
that around 70-80% of cases have underlying psychiatric disor-
der. A syndrome named “van Gogh syndrome” has been the name
E-PP0630 given to patients attempting self-mutilation under the influence of
HIV infection and sexuality imperative hallucinations.
R. Feki1* , L. Zouari1 , S. Omri1 , M. Koubaa2 , M. Maalej1 , N. Charfi1 , J. Disclosure of interest.– The authors have not supplied a conflict of
Ben Thabet1 , M. Ben Jemaa2 , M. Maalej1 interest statement.
1 Hopsital Hedi Chaker, Psychiatry C, Sfax, Tunisia; 2 Hopsital Hedi
Chaker, Infectious diseaise, Sfax, Tunisia

The association between serotonin
Background and aims.– HIV infection is a very intimate issue since reuptake inhibitors and erectile
it’s transmitted through sexual intercourse. By the use of antiretro-
viral therapy and increased life expectancy, the sexuality has
dysfunction in depressed patients
W. Kabtni* , C. Bencheikh, A. Rebai, R. Maamouri, A. Baatout, I.
become a concern for people living with HIV, as well as for clin-
Bouzouita, M.W. Krir, H. El Kefi, A. Oumaya
icians.
Military Hospital, psychiatry department, Tunis, Tunisia
The purpose of our study is to identify sexual disorders affecting * Corresponding author.
patients living with HIV infection.
Methods.– This is a descriptive cross-sectional study regarding 55 Background and aims.– Erectile dysfunction (ED) is a common male
patients living with HIV infection. sexual dysfunction encountered in depressed patients (69%), aggra-
An anonymous, designed questionnaire was used to collect the vated by serotonin reuptake inhibitors (SRI) and has a significant
socio-demographic and clinical data; and sexual disorders using impact on the couples’ relationships in everyday life.
DSM – 5 criteria. Our study aims to determine the prevalence of erectile dysfunction
Results.– The mean age was 44 years and the sex ratio (♂/♀) was in depressed patients treated with SRI antidepressant and to study
0.96. The participants had been diagnosed with HIV infection until the association between ED, the severity of depressive symptoma-
more than 6 years before the interview. According to the classifica- tology and SRI drugs use.
tion of the US Centers for Disease Control and Prevention, 60% of the Methods.– This is a retrospective case-control study of 60 cases,
participants were in stage A; 21.8%were in stage B and 18.2% in stage including 30 controls and 30 patients with depressive disorder (15
C. Among the participants, 21.8% declared that they don’t have any treated with SRI and 15 treated with non-SRI antidepressant).
sexual contact after HIV diagnosis. For men, we noticed delayed
The included cases have no notable medical history and answered E-PP0634
the “Patient Health Questionnaire (HQP-9)” and the “International Impact of sexual side effects on
Erectile Function Index (IIEF15)”
medication adherence in real-world
Results.– Erectile dysfunction was found in 13.33% of controls
Versus 73.33% of patients followed for depressive disorder.
Psychiatry
A depressive disorder of moderate to severe intensity was identified F. Tastet1 , P. Delbrouck2 , M.A. Léonard2 , A. Ricoux2 , M. Dumas2 , E.
as a risk factor for erectile dysfunction (OR> 1). Esposito2 , J. Mallet3*
1 Clinique Parassy - Groupe Clinéa, Psychiatry, SALLANCHES, France;
The use of SRI was identified as a risk factor for erectile dysfunction 2 Centre Hospitalier de Saint-Nazaire, Pole E, Saint-Nazaire, France; 3
(OR> 1).
Conclusions.– ED is aggravated by the severity of depressive disor- Centre Hospitalier Louis Mourier, Psychiatry, Colombes, France
der and by SRI, which is one of the explanations for non-compliance
to treatment. Background and aims.– Medication adherence refers to whether
Thus, a systematic evaluation of sexual function during treatment patients take their medications as prescribed, as well as whether
would be beneficial. they continue to take their prescribed medication.
Disclosure of interest.– The authors have not supplied a conflict of Medication nonAdherence is a major concern to clinicians in
interest statement. psychiatry, but also to healthcare systems, because of mounting
evidence that it is associated with adverses outcomes and higher
costs of care. Psychotropic drugs have many side effects, including
E-PP0633
sexual side effects.
The volunteer bias in sexuality study. Objective.– To determine
a psychological description of the - patients medication adherence in a public consultations setting
male sample - the association between nonAdherence and sexual side effects
J. Kurpisz1* , K. Nowosielski2 , R. Kowalczyk3 , M. Lew-Starowicz4 , J. Methods.– It was an observational multicenter study (France).
Samochowiec1 Self-questionnaires were available to patients prior to their consul-
1 Pomeranian Medical University, Deparment and Clinic of tation in their psychiatric ward. These anonymous questionnaires
Psychiatry, Szczecin, Poland; 2 Medical Collage in Sosnowiec, assessed patients’ compliance and questioned them about the exis-
Department of Sexology and Family Planning, Sosnowiec, Poland; 3 tence/absence of sexual side effects. This study was approved by
Andrzej Frycz Modrzewski Cracow University, Department of local Ethic Committee.
Sexology, Cracow, Poland; 4 Institute of Psychiatry and Neurology, Results.– 227 patients were included, 178 with complete medica-
3rd Psychiatric Clinic, Warsaw, Poland tion adherence data. Of these, 160 also answered questions about
* Corresponding author. sexuality.59% of patients feel they have sexual side effects related
to their drug treatment. 17% answered that they changed/modified
Background and aims.– their treatment for this specific reason.24% of patients have poor
Introduction.– The volunteer bias is a perceptible problem in multi- adherence according to MARS. There is a correlation between drug
ple studies, but it especially affects findings related to sexuality. It non-adherence and the presence of sexual side effects. Women
includes specific participants’ personality traits and attitudes, as aged 46 to 60 are particularly exposed to sexual iatrogenic drug,
well as their approach to fear of judgment related to the study but would not change their treatment for this reason, contrary to
content. men.
Objectives.– Description of the personality traits and other charac- Conclusions.– Sexual side effects may impact medication adherence,
teristics of the sexology study volunteer participants. and should be evaluated in clinical routine. These data should be
Methods.– The study concerned sample of 200 polish men (response replicated on larger samples.
rate 25%) aged 18-65, who were asked to fulfil an anonymous ques- Disclosure of interest.– The authors have not supplied a conflict of
tionnaire battery about ‘mental and sexual health’, which consisted interest statement.
of sexological (SIS/SES, IIEF), gender (BSRI), personality (NEO-FFI)
measures, general health and sociodemographic survey.
Results.– The study participants were found to have signifi- E-PP0635
cantly lower scores on neuroticism scale, while higher scores on Orgasm disorders in tunisian women
extraversion and conscientiousness scales in comparison to general
population
population. They were mainly heterosexual, moderately religious,
F. Medini1* , A. maamri1 , H. zalila2 , Y. kissi3
had secondary or high education, were city inhabitants, had sex- 1 Razi Hospital, Mannouba, Tunisia; 2 Hospital Razi, Mannouba,
ual partners (with whom had predominantly very good or good
Tunisia; 3 Sousse Hospital, Psychiatry, Sousse, Tunisia
relationships’ quality). Their attitudes toward one’s self and body * Corresponding author.
were quite positive, their sexual attractiveness self-assessment was
quite high. 18% of the sample declared engaging in excessive sexual Background and aims.– Orgasm disorders are the second most
behaviours and 24% met criteria for erectile dysfunctions. 2% admit- important reason in women sexological practice
ted to be victims of sexual abuse in childhood. In the sample mean Aims.– To evaluate the clinical characteristics of orgasmic function
sexual initiation age, the levels of stereotypical femininity and mas- in a Tunisian women population to study the sexual function in this
culinity were comparable the general population. The dominating population and to evaluate the psychological impact of a possible
gender types were masculine and androgynous. orgasmic disorder.
Conclusions.– The volunteers who took part in sexology study have Methods.– A descriptive and analytical cross-sectional study of 363
different psychological descriptions than the overall population. women was evaluated by an online scale using the FSFI and HAD
This fact seriously affects interpretation possibility of the gathered scales.
findings. Results.– Women were aged between 21 and 51 years old, most
Disclosure of interest.– The authors have not supplied a conflict of were married, with a high level of education. An orgasm disorder
interest statement. was noted in 70% of cases and 58% of women had a desire disorder.
At the FSFI scale, the total score of participants in the area of orgasm
was impaired with an average score of 4.4. Five percent of women
had depressive symptomatology and 30% had anxious symptoma-
tology. We found a statistically significant positive correlation Background and aims.– Interpersonal and communication skills
between the FSFI sub-score at orgasm and the items: Age, num- have been considered a core competency in clinical practice and
ber of children, number of sexual intercourse/month, cognitions a very important part of quality in medical care (Batalden, 2002).
on orgasm and items HAD score Anxiety, HAD score Depression. The Communication Assessment Tool (CAT; Makoul et al., 2007)
Conclusions.– Identifying the knowledge and the experience of is a 14-item unidimensional questionnaire focusing on patients’
the orgasm disorder among Tunisian women will help to correct perception of physician’s communication and interpersonal per-
misconceptions and allow a better management of this sexual dys- formance. Its original version presented excellent reliability and
function. construct validity. Objective: to analyze the construct validity,
Disclosure of interest.– The authors have not supplied a conflict of using Confirmatory Factor Analysis (CFA), the convergent validity
interest statement. and the reliability of the Portuguese version of the CAT.
Methods.– A sample of 244 adults [162 (66,4%) women; mean
age = 33.67 ± 13.478 years] completed the preliminary Portuguese
E-PP0636
version of CAT and the Patient Perception of Patient-Centeredness-
Perceptions and thoughts related with 16 (PPCD-16; Macedo et al., 2012). Participants also answered three
sexuality in pregnant women Likert scale question to assess satisfaction and adherence. The CFA
F. Oflaz was obtained using the AMOS 23 software.
Koç University, School of Nursing, Istanbul, Turkey Results.– CFA showed a good fit for the unidimensional model
(2 /df = 2.53; CFI = 0.96; TLI = 0.95; RMSEA = 0.08; p < 0.01). Overall
scale reliability was high, presenting excellent internal consistency
Background and aims.– The changes, combined with cultural, reli- (Cronbach’s alpha = 0.96). Pearson correlations with PPPC-16 total
gious, and familial factors, affect sexuality and sexual activity and dimensional (Empathy and Active patient involvement) were
during pregnancy. high (r > .650); with satisfaction (r = .385) and adherence (r = .279)
The purpose of this study is to describe how pregnant women per- were moderate (all p < .01).
ceive and live their sexuality during the pregnancy. Conclusions.– The Portuguese version of CAT is a reliable and valid
Methods.– 51 pregnant women who agreed to participate were instrument to assess patient perception of physician’s communica-
interviewed, for this qualitative descriptive study. tion and interpersonal skills. In this Portuguese community sample
The data were collected using face-to-face interview by using a the CAT scores were lower than those of the original (American)
semi-structured interview form. The questions included thoughts scale, which indicates that clinical communication skills should
and perceptions of women related to sexuality. Each interview improve in our country. Thus, this instrument is useful in research
lasted 20-25 minutes and tape-recorded. Then, each interview tran- projects of communication skills in clinical practice.
scribed verbatim and coded by the researcher and one specialist Disclosure of interest.– The authors have not supplied a conflict of
until they reach an accurate understanding of what participants interest statement.
meant. Later, similar statements were put together to create the
themes of the study.
Results.– 39% of women had their first pregnancy, 58% had planned E-PP0638
pregnancy and the mean of age was 28,6. Three themes emerged by Source of stress and response to stress
the relevant expressions of the participants were marital relation-
ship, pregnancy experience and motherhood experience. Related
in executives
B. Barmi
to pregnancy, physical problems such as nausea, vomiting, growth
Fortis Escort, Psychology, New Delhi, India
of the abdomen, weakness-fatigue and pain was stated and addi-
tionally they talked about a decrease desire and want to control Background and aims.– Aim of the study was to identify sources
sexual intercourse (when/how) by themselves. Regarding mater- of stress for managerial level corporate employees from multi-
nal life, women expressed that since being a mother experience or national corporations impacting their work life balance.
maternal feeling is in the foreground, the frequency of sexual inter- Methods.– Data of 5 years from target respondents was reflected by
course was decreasing. Also, women stated that being a wife needs them and the same were utilized to design a survey questionnaire.
to continue sex life, and husband not to be rejected when they want Data from 2000 employees aged from 30–45 years was collected.
to sex. Mean, median and standard deviations were calculated. Also, non
Conclusions.– Sexual activities of women are changing in pregnancy parametric statistics were used.
and needed counseling. Results.– The research revealed seven major significant sources of
stress amongst which long working hours is the major stressor
affecting 48% of employees followed by work pressure (40%), loss of
E-Poster Presentation: Mental Health work-life balance (32%) and role clarity with role conflicts affecting
Care/Promotion of Mental Health as many as 30% of the respondents. On the hand, manager’s inabil-
ity to recognize stress as well as find solutions for it affects 24% and
20% employees respectively. Also, the study revealed the primary
responses to the stressors range from anger as elicited by 80% of the
employees, chronic fatigue experience by 65%, 60% of them suffered
interest statement.
from anxiety followed by poor decision making, insomnia, psycho-
somatic pain and an equal number of respondents being affected
E-PP0637 by reduced attention, concentration and disturbed sexuality.
Conclusions.– Implications of the study can be concluded by say-
Portuguese validation of the ing that people respond to stress in a maladaptive manner thereby
communication assessment tool perpetuating the stress cycle and disturbing their emotional health
A. Macedo1 , D. Moura1 , A. Araújo2* , M.J. Soares1 , C. Marques1 , A. distrupting the work-life balance.
Pereira1 Disclosure of interest.– The authors have not supplied a conflict of
1 Institute of Psychological Medicine, Faculty of Medicine, Coimbra
interest statement.
University, Coimbra, Portugal; 2 Institute of Psychological Medicine,
Faculty of Medicine- University of Coimbra, Coimbra, Portugal
E-PP0639 Results.– The Summer School Program will include topics such
Do patients with psychiatric disorders as: Legislation, Ethics and Professional Responsibility, Psychoso-
want to get involved in the evaluation cial Rehabilitation and the Evidence Based Psychosocial Method,
Psychotherapeutic Approach and Psychotherapy Psychotherapy;
of the psychiatric health care? Trauma and PTSD; Research into social psychiatry and psychother-
N. Berzina-Novikova, M. Taube
apy; Mental Health Promotion and Early Detection of Mental
Riga Stradiņš university, Psychiatry and addiction disorders, Riga,
Disorders; Employment and housing care for people with mental
Latvia
disorder; Therapy community.
Conclusions.– The Summer School will increase the knowledge and
Background and aims.– Assessment of the treatment in psychiatric competences of mental health professionals in the implementation
inpatient departments and treatment result evaluation by patients of modern methods of social psychiatry and psychotherapy.
themselves plays crucial role in quality evaluation and planning Disclosure of interest.– The authors have not supplied a conflict of
the improvement strategies. The importance of the study stresses interest statement.
WHO conducted research in 2016 about deinstitutialization pro-
cess, where authors claim that the health care system needs to meet E-PP0641
patients’ needs. According to Zendjidjian et al., (2014), an appro-
Internal consistency of the spanish
priate and patient need oriented health care encourages patients
to seek help and contributes to the management of relapses and family orientation of community and
outcomes. agency services: family and
Objectives.– To determine patients’ satisfaction with a quality of practitioner’s version
health care services in psychiatric inpatients and get response rates S. García-Ventura1 , M. Joana1 , C. Giné1 , F. Calvo2*
in different psychiatric clinics, patients were asked to fill the PIPEQ- 1 Universitat Ramon Llull, Psychology, Barcelona, Spain; 2 Institut
OS (Psychiatric Inpatient Patient Experience Questionnaire - on d’Assistència Sanitària, Health, Girona, Spain
site) questionnaire in three psychiatric hospitals in Latvia. * Corresponding author.
Methods.– The questionnaire was filled by patients 1 day before the

discharge. Preliminary data were evaluated and compared between Background and aims.– Early Childhood Intervention (ECI) prac-
central and regional hospitals. titioners in Spain are transforming their clinical praxis to a
Results.– Pilot study was conducted for 8 months. 886 question- Family-Centered Care approach. Due to that process, tools to
naires were filled and returned back. 50% of discharged patients appraise the use of Family-Centered Practices (FCP) are necessary.
returned filled questionnaire in capital hospital, meanwhile 39% The Family Orientation of Community and Agency Services (FOCAS)
and 11% returned filled questionnaire in regional psychiatric hos- Scale assess actual and desired FCP from the point of view of fam-
pitals. Focus group discussions among hospital specialists were ilies and practitioner. The objective of this study is to analyse the
organized. internal consistency of the family and practitioner’s Spanish ver-
Conclusions.– Patient response rate in regions has shown the low sion of the FOCAS scale.
patients’ interest in the evaluation of the health care quality. Fur- Methods.– 317 families of children receiving ECI and 82 ECI
ther study of patient and health care provider related factors need practitioner completed the FOCAS scale. Descriptive and Internal
to be conducted. consistency analysis of the scale were performed.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Cronbach’s Alpha for the total scale scores was more than
interest statement. acceptable (table 1). The correlation between actual and desired
scores was r = 0.67 (p = .01) for the family version and r = 0.48
(p = .01) for the practitioner version.
E-PP0640
Summer school project: mental health
in the community
D. Britvić1* , S. Ivezić Štrkalj2
1 University Hospital Split, Department for Psychiatry, Split, Croatia;
2 Psychiatric Hospital Vrapče, Department for Social Psychiatry,
Table 1. Descriptive and internal consistency analysis of the FOCAS
Zagreb, Croatia scales
Conclusions.– Our results confirm that the FOCAS scale have a good
Background and aims.– internal consistency, suggesting is a valid measure instrument in
Introduction.– The development of mental health protection in the order to assess family and practitioner appraisals of actual and
Republic of Croatia envisages the implementation of comprehen- desired FCP in our context.
sive mental health care for people with mental disorders in two Disclosure of interest.– The authors have not supplied a conflict of
important areas of social psychiatry and psychotherapy. interest statement.
Objectives.– The aim is to present the development of the Mental
Health Community Summer School project.
Methods.– The Department of Psychological Medicine at the Faculty E-PP0642
of Medicine in Split is launching a summer school project: Mental Eating disorders, anxiety and
Health in the Community. In the first phase, the creation of a sum- depression among Tunisian students
mer school curriculum is started, with the activities that consist A. Chaabouni1* , M. Maalej1 , Y. Mejdoub2 , S. Omri1 , M. Ben Jemaa2 ,
of the establishment of cooperation and agreement on the way of M. Ben Yahya3 , L. Zouari1 , S. Yaich2 , J. Dammak2 , M. Maalej1 , N.
work, the development of a common curriculum, and the regulation Charfi1 , J. Jedidi2 , J. Ben Thabet1
of interpersonal relationships. The next stage is the development of 1 Hedi Chaker University Hospital, Department of Psychiatry “C”, Sfax,
teaching materials. The final stage is the maintenance of the sum- Tunisia; 2 Hedi Chaker University Hospital, Department of Preventive
mer school. Cooperation with the Faculty of Medicine in Zagreb, the Medicine, Sfax, Tunisia; 3 Higher Institute of Nursing Sciences of Sfax,
Faculty of Medicine in Ljubljana and colleagues from the Eu Net- Higher Institute of Nursing Sciences of Sfax, Sfax, Tunisia
work for Mental Health from the Netherlands is being established. * Corresponding author.
Background and aims.– Eating disorders is a persistent and severe Disclosure of interest.– The authors have not supplied a conflict of
disturbance of eating habits that promotes the appearance of interest statement.
impaired physical health and psychosocial functioning. They fre-
quently occur with other psychiatric disorders.
In our study, we aimed to examine the relationships betweenEating E-PP0644
disorders, anxiety and depression among Tunisian students. Does engagement in regular physical
Methods.– This was a cross-sectional study of 589 students enrolled exercise help in reduction of
at Sfax universities in Tunisia during the academic year 2017–2018.
readmission to an adult inpatient
Results.– The participants were female in 71.1% of the cases with a
mean age of 21.2 years. Students were single in 63.8% of the cases. floor?
Fifty-two percent of students lived in the parental home. Among J. Chowdhury* , P. Manocha, R. Shengelia, P. Korenis, I. Lee
the participants, 33.6% had an ideal weight. Twenty five percent of BronxCare Health System, Psychiatry, New York, USA
participants were smokers,34% were alcohol drinkers and 25% con-
sumed psychotropic drugs. Eating disorders were noted in 38.4% of Background and aims.– In 2013, the United States spent nearly $201
the participants, depression in 21.8% and anxiety in 29.9% of the billion on mental health issues such as anxiety and depression. It is
cases. The presence of eating disorders was correlated with the also established in literature that psychiatric patients have a high
female gender (p = 0.022) and the place of residence (p = 0.009). incidence of medical comorbidities including cardiovascular sys-
Eating disorders were associated with anxiety (p = 0.000) andde- tem. We hypothesized that those psychiatric patients who engage
pression (p = 0.024). in regular physical exercise will have reduced number of readmis-
Conclusions.– Our results attest the importance of the level of eating sion rates when compared to other patients.
disorders in students and unveil the impact of their emotional state Methods.– In this quality improvement project, patients were
in the appearance of these disorders. Some preventive measures recruited from BronxCare adult outpatient clinic in a self-health
could reduce the risk of developing this addiction among students action plan for empowerment (INSHAPE) program funded by
and thus prevent the occurrence of its complications. the hospital where individuals who were overweight (>25) were
Disclosure of interest.– The authors have not supplied a conflict of trained on physical activity, healthy eating goals, and attention to
interest statement. their medical needs. Patients were followed for up to two years in
this program, where they were expected to go to the gym three
times a week and complete six nutritional classes.
E-PP0643
Results.– These individuals (n = 32) were more often found to be
Perceived stress and self-esteem females (72%, n = 23), Blacks (47%, n = 15), Hispanics (44%, n = 14),
among the students of Sfax University Obese (91%, BMI > 30, n = 29). It was noted that most of these
in Tunisia patients (84%, n = 28) did not have any psychiatric inpatient re-
N. Hili1 , M. Maalej1 , Y. Mejdoub2 , A. Chaabouni1* , S. Omri1 , M. Ben admissions or any admissions at all (68%, n = 22) when compared
Hamida2 , M. Ben Yahia3 , L. Zouari1 , S. Yaich2 , J. Dammak2 , M. to their counterparts.
Maalej1 , N. Charfi1 , J. Jedidi2 , J. Ben Thabet1 Conclusions.– The above results show that combining exercise with
1 Hedi Chaker University Hospital, Department of psychiatry “C”, mental health treatment reduces the utilization of inpatient psy-
Sfax, Tunisia; 2 Hedi Chaker University Hospital, Department of chiatric services. The possible explanation of this may be that these
Preventive Medicine, Sfax, Tunisia; 3 Higher Institute of Nursing individuals are more likely to remain compliant with medications
Sciences of Sfax, Nursing, Sfax, Tunisia and adhere with their treatment plans.
interest statement.
Background and aims.– The prevalence of stress among students is
high. This can affect negatively their wellbeing. Moreover, a low
self-esteem may lead to more serious issues and damage in the E-PP0645
long run. Communication competence and the
In this study, we tried to explore the eventual links between stress,
intensity of anxiety and stress in
self-esteem and some personal and social factors.
Methods.– We carried out a cross sectional study among 756 medical staff
students of faculties in Sfax (Tunisia), during the academic K. Cyranka1* , K. Szułdrzyński2 , M. Nowina Konopka3 , D. Dudek1
1 Department of Psychiatry Jagiellonian University Medical College,
year 2017/2018. Each participant filled in a questionnaire which
included, among others, thePerceived Stress Scale (PSS) and the Adult Psychiatry Clinic, Krakow, Poland; 2 Department of
Rosenberg Self Esteem Scale (SES). Interdisciplinary Intensive Care, Jagiellonian University Medical
Results.– The average age of students was 21.25. Among the partic- College, Krakow, Poland; 3 Institute of Journalism Media and Social
ipants, 71.3% were women (N = 539). The average scores SES and Communication, Faculty of Management and Social Communication
PSS were respectively 28.22 (SD = 5.693) and 30.15 (SD = 5.967). Jagiellonian University, Krakow, Poland
The level of stress was pathological in 72.6% (N = 549) of partic-
ipants. One hundred and sixty seven participants (22.31%) had a Background and aims.– The aim of the study was to explore the rela-
very low self-esteem and 308 (40.7%) of them had low self-esteem. tionship between communication competences and the selected
The SES score was not influenced by the following factors: gender psychological parameters: anxiety, coping with stress strategies,
(p = 0.349), financial situation (p = 0.36) and academic performance the sense of mental well-being, the sense of security and general-
(p = 0.248). There was a significant difference of SES score according ized self-efficacy in medical staff.
to theinstitution (p = 0.015). The SES score was negatively corre- Methods.– The pilot study, being a part of broader research project,
lated to PSS score (p < 0.01 and r = −0.5) involved 30 medical doctors working in hospital wards, 30 nurses
Conclusions.– The majority of students had a pathological stress and working in hospital wards and 20 representatives of other medical
a low self-esteem. The more they were stressed, the lower was staff.
their self-esteem. A specific training on stress management could Inclusion criteria.– Informed consent to participate in the study.
be added to the academic program. It is likely to improve both the Doctors, residents, nurses and medical personnel employed at the
self-esteem and the level of stress in these students.
wards of the University Hospital in Krakow or working in wards E-PP0647

under the contract with the University Hospital in Krakow Study of the relationship of behavior,
Exclusion criteria.– Employment at the University Hospital for a
self-concept and attachment on
period of <6 months. The research involved interviewing for per-
sonal data: age, gender, education, workplace, seniority. To collect
institutionalized children
the measured psychological parameters the following tools were L. Amador, C. Marques, C. Duarte* , H. Espírito-Santo, L. Lemos
used CISS - Coping Inventory For Stressful Situations, Mini-COPE - Instituto Superior Miguel Torga, Psychology, Coimbra, Portugal
Brief Coping Orientation to Problems Experienced Inventory, STAI -
State-Trait Anxiety Inventory, PSS-10 - Perceived Stress Scale, GSES Background and aims.– Institutionalization means a cut, absence or
- General Self-Efficacy Scale. To assess communication a Commu- dysfunctionality of the relationship with the parental figures and
nication Competency Test by Maria Nowina Konopka was used. leads to the creation of new ties and new processes of attachment.
The research was carried out anonymously, after giving written This study aims to evaluate the association between sociodemo-
information on the research objectives to the respondents. graphic variables and behavior, self-concept and relationships of
Results.– Communication is a core clinical skill and an essential institutionalized children and adolescents.
component of general clinical competence. The study brings signif- Methods.– The sample of this exploratory study included 32 insti-
icant observations about the relation between major psychological tutionalized children aged between 9 to 17 years (M = 14.56;
features and clinical competence in personal staff working in hos- SD = 2.213). They were assessed through the Piers-Harris Children’s
pital wards. Self-Concept Scale-2, the Inventory of Parent and Peer Attachment
Conclusions.– The results are inspiration for further analyses and the Child Behavior Checklist from Achenbach.
planned in this research project, including also doctor-patient com- Results.– A significant relationship between years of institutional-
munication. ization and maternal figure – alienation and differences in the level
Disclosure of interest.– The authors have not supplied a conflict of of communication between young people and mothers according
interest statement. to age [M (9–15) = 19.50; M (16–17) = 13.50]. Reproaches in school
were related to behavior problems, alienation from friends and lack
of energy. Self-concept was related both to maternal attachment
E-PP0646
and to attachment with friends. The more popular the children felt,
The diet and aggression study: the less alienation from friends, but also the less communication.
reducing aggression among chronic Conclusions.– Attachment was associated with self-concept, years
psychiatric inpatients through of institutionalization and age emphasizing the importance of
nutritional supplementation intervention and reinforcement of bonds with significant others
N. De Bles* , N. Rius Ottenheim, A.M. van Hemert, E.J. Giltay from early ages. This study found a high number of reproaches and
LUMC, Psychiatry, Leiden, The Netherlands their association with behavior problems, alienation from friends,
* Corresponding author. and lack of energy which means that the fragile situation of these
children may have a significant impact on their social, emotional
Background and aims.– Aggressive incidents are highly prevalent and occupational future.
among chronic psychiatric inpatients. Studies have demonstrated Disclosure of interest.– The authors have not supplied a conflict of
the potential of supplementation to reduce aggression in malad- interest statement.
justed children and forensic populations. The aim of the current
study is to test the hypothesis that multivitamin-, mineral-, and n-
3 fatty acids (n-3FA) supplementation reduces the incidence and E-PP0648
severity of aggressive incidents among chronic psychiatric inpa- Spiritual well-being and mental
tients. health in institutionalized older adults
Methods.– The Diet and Aggression study is a pragmatic, multi- L. Lemos1 , M. Neves2 , I. Garcia1 , H. Espírito-Santo1*
center, randomized, double-blind, placebo controlled, intervention 1 Instituto Superior Miguel Torga, Psychology, Coimbra, Portugal; 2
trial. Eligible for the study are psychiatric inpatients aged 18 years Instituto Superior Miguel Torga, Coimbra, Portugal
or older, who are residing in long-stay psychiatric wards. During 6 * Corresponding author.
months one group receives 3 supplements daily: 2 Orthica Multi
®
Energie (containing vitamins and minerals) and 1 Orthica Fish Background and aims.– Cognitive and functional changes seem to
®
EPA Mini (containing n-3FA). The control group receives 3 placebo be related to higher levels of spiritual well-being across lifespan
capsules. being more expressive in older people. According to research, older
Results.– The main parameter is the number of aggressive incidents people with higher levels of spiritual well-being have less depres-
as registered with the Staff Observation Aggression Scale-revised sive and anxious symptomatology, are more optimistic, and have
(SOAS-R). At three points during follow-up questionnaires will more hope for the future. Little is known about spirituality, and
be administered: the Aangepaste Versie van de Agressievragenlijst its correlates in institutionalized older adults. Thus this study aims
(AVL-AV), a 12 item self-report questionnaire about feelings of to assess the relationship between spiritual well-being, cognitive
aggression; the World Health Organization Quality of Life Ques- functioning, depressive, and anxious symptoms in institutionalized
tionnaire (WHOQOL-BREF), a 26-item observer rated quality of life elderly.
instrument; and a 25-item observer rated instrument that includes Methods.– The sample included 101 institutionalized older adults
the Montgomery Asberg Depression Rating Scale (MADRS). Blood (33 male and 68 female), aged between 65 and 96 years (M = 81.88,
samples will be taken to determine nutritional status. At four time SD = 7.86). They were assessed through the Spiritual Well-Being
points, nursing staff will fill out the Social Dysfunction Aggression Questionnaire (SWBQ), the Geriatric Anxiety Inventory (GAI), the
Scale (SDAS), measuring observed levels of aggression and social Geriatric Depression Scale (GDS), the Montreal Cognitive Assess-
dysfunction. ment (MoCA), and the Positive and Negative Affect Schedule
Conclusions.– In case the results are promising, dietary supplements (PANAS).
may be part of standard care in long-stay psychiatric wards. Results.– SWBQ was negative and statistically significant related
Disclosure of interest.– The authors have not supplied a conflict of to the cognitive functioning measured by MoCA (p < 0.05) and to
interest statement. the depressive symptomatology measured by GDS (p < 0.01). SWBQ
was also statistically significant related to the positive affect mea-
sured by PANAS (p < 0.05). Spiritual well-being was statistically This study aimed (i) to investigate the gender role in the univer-
different in terms of gender (p < 0.01), marital status (p < 0.05) and sity students’ psychosocial adjustment; (ii) and the relationship
profession (p < 0.05). between spirituality, stress vulnerability and quality of life.
Conclusions.– As people age, there seems to be a tendency to Methods.– The sample included 308 students from University of
increase levels of spirituality. Older adults with higher levels of spir- Aveiro. The participants filled in the Spiritually Scale, the World
ituality have lower depressive symptomatology and higher levels of Health Organization Quality of Life – Bref (WHOQOL-Bref) and the
positive affect, which underlines the relationship between spiritual Stress Vulnerability Questionnaire (23 SVQ).
well-being and mental health. Results.– The results pointed to gender differences in spirituality
Disclosure of interest.– The authors have not supplied a conflict of level and vulnerability to stress. The female university students
interest statement. presented more spirituality beliefs and higher scores of stress
vulnerability, more specifically in the domains of perfectionism,
frustration intolerance and dramatization of existence. Signifi-
E-PP0649 cant associations between spirituality and students’ psychosocial
Stigmatization towards psychiatry adjustment were also found. Particularly increased hope/optimism
and psychiatric disorders among were related to decreased vulnerability to stress and promotion of
the physical, psychological, social and environmental domains of
medical students in Tunisia
quality of life.
C. Ben Said* , N. Bram, R. Maamouri, W. Homri, I. Ben Romdhane, R.
Conclusions.– The conclusions confirmed the need to consider inter-
Labbane
vention on spirituality within this context, without disregarding
Razi Hospital, Psychiatry C, Mannouba, Tunisia
* Corresponding author. the differences of gender in the experience of the spiritual dimen-
sion and exposition to stressors.
Background and aims.– Mental illnesses stigma and discrimination Disclosure of interest.– The authors have not supplied a conflict of
have been described as having worse consequences than the con- interest statement.
ditions themselves.
Anti-stigma interventions for medical students have been studied
in several countries, mainly in developed ones. E-PP0651
The aim of this study is to explore whether clinical trainings in psy- Humiliation in adolescence: is there a
chiatry have an impact on medical students’ stigmatizing attitudes relationship with early negative
towards psychiatry and psychiatric disorders. experiences, aggressiveness, revenge
Methods.– The medical student version of the scale Mental Illness:
and paranoia?
Clinicians’ Attitudes (MICA-v2) was used to measure students’ atti-
M. Cunha1* , O. Dias2 , A. Galhardo1 , I. Massano-Cardoso3
tudes towards psychiatry and persons with psychiatric disorder. 1 Miguel Torga Institute/CINEICC - University of Coimbra, Clinical
The questionnaire was completed online by medical students of the
Psychology, Coimbra, Portugal; 2 Miguel Torga Institute, Clinical
faculty of medicine of Tunis whose levels of study vary from the
Psychology, Coimbra, Portugal; 3 Instituto Superior Miguel Torga and
first to the sixth year. Participation in psychiatry clinical training
Faculty of Medicine of the University of Coimbra and Faculty of
programs in second and fifth year was specified. MICA-v2 scores of
Economics of the University of Coimbra, Ceisuc, Coimbra, Portugal
students who attended clinical training in psychiatry and those not * Corresponding author.
were compared.
Results.– 168 students completed the MICA-v2 scale: MICA total Background and aims.– Humiliation is a multi-faceted construct
score was equal to 44.78. In fifth and sixth year medical students encompassing experiences of disconnection leading to several psy-
who attended both clinical trainings in psychiatry, MICA score was chological or behavioural difficulties, particularly in adolescence. A
45.13. Students in first and second year who did not attend any better understanding of its relationship with similar constructs may
clinical courses had a score of 43,65. Scores according to the level of be relevant for early detection and development of intervention
study, from first to sixth year, show a negative attitude increasing strategies aimed at buffering its negative impact.
with higher study level. Results showed no significant change in Study the relationship between humiliation and early negative
MICA-v2 scores between students who had had clinical trainings experiences, revenge, paranoia and aggressiveness in adolescents.
in psychiatry and those who had not. Methods.– The sample included 268 adolescents (134 males and 134
Conclusions.– Medical students need to be targeted for anti-stigma females), aged between 12 and 18 years old, attending 5th through
educational interventions as future healthcare providers in charge 12th grades. Participants completed the following self-report ques-
of persons with psychiatric disorders. tionnaires: Humiliation Inventory, Early Life Experience Scale,
Disclosure of interest.– The authors have not supplied a conflict of General Paranoia Scale, Aggression Questionnaire and Vengeance
interest statement. Scale.
Results.– Results showed gender differences, with girls showing
more humiliation experiences, subordination, verbal aggressive-
E-PP0650 ness, anger, hostility and paranoid beliefs. Boys revealed more
Spirituality, quality of life and stress physical aggressive behaviors. A correlation pattern was found
vulnerability in university students in the expected direction among the study variables. Humilia-
F. Carvalho1* , F. Pereira2 , S. Monteiro2 , A. Pereira2 tion showed a moderate and positive relationship with early life
1 Centro de Investigação em Neuropsicologia e Intervenção experiences and paranoia. It showed a low negative correlation
Cognitivo-Comportamental, Universidade de Coimbra, Coimbra, with aggressiveness and was not associated with vengeance. The
Portugal; 2 Universidade de Aveiro, Faculdade de Psicologia, Aveiro, Predictor model of humiliation was significant and revealed the
Portugal unique and independent contribution of aggressiveness-hostility,
* Corresponding author. experiences of subordination in childhood, paranoid ideation, and
physical aggressiveness.
Background and aims.– Enrolling in the University it’s an emotion- Conclusions.– Results allowed the identification of associations
ally demanding transition period. Some university students report between humiliation and constructs such as early negative
stress and impairment of quality of life. experiences in childhood, aggressiveness, paranoia and revenge.
Considering its negative impact on current and subsequent devel-
opment of adolescents, a better understanding and mapping of E-PP0653

humiliation in the adolescent population is useful not only for The impact of greece’s economic crisis
early detection, but also for designing preventive and intervention
on students’ requests for counselling
strategies.
in secondary education
interest statement. L. Iliopoulou1* , V. Koutras2 , V. Basogianni3 , E. Fidi3 , K. Komninou3 ,
S. Gonta3
1 General Hospital of Ioannina “Hatzikosta”, Psychiatric Sector,
E-PP0652 Ioannina, Greece; 2 University of Ioannina, Preschool Education,

Ioannina, Greece; 3 Center of Addiction Prevention and Promotion of
Factor structure of a 36-item
Psychosocial Health “Schedia”, Prevention, Ioannina, Greece
satisfaction and well-being of the * Corresponding author.
elderly scale (SWE-36)
T. Doungyota1* , C. Phromsida2 , N. Wongpakaran3 , P. Udomratn4 , Background and aims.– The Center of Addiction Prevention and
H. Boonchareon5 , S.A. Phanprathum6 , P. Khaektao6 , K. Promotion of Psychosocial Health “Schedia” applies prevention
Hongchukiet7 , W. Muenmarerng1 , C. Tippinid1 , K. Sungprakhong6 , programs, and provides counselling services in secondary schools.
P. Chucheep8 , S. Tanimpas9 , Y. Paniltangkool1 , S. Musiko6 , S. Counselling has been implemented since 1999 with the primary
Panpech6 , P. Chetkuntod6 , S. Sommaluan10 , B. Tipnurak6 objectives of prevention for students, parents and teachers, psy-
1 Suansaranrom Hospital, Acadamic Section, Surat Thani, Thailand; 2 chological support, changing of attitudes towards psychosocial
Suansaranrom Hospital, Director office, Surat Thani, Thailand; 3 difficulties and the stigma associated with them. Individual ses-
Chiang Mai University, Faculty of Medicine, Chiang Mai, Thailand; 4 sions with a counsellor are provided throughout the school year, in
Prince of Songkhla University, Faculty of Medicine, Songkhla, a fixed space and time at school. The study was aimed to examine
Thailand; 5 Southern Institute of Child and Adolescent Mental Health, whether the economic crisis in Greece had an effect on the students’
Director Office, Surat Thani, Thailand; 6 Suansaranrom Hospital, requests for counselling.
Nursing Office, Surat Thani, Thailand; 7 Suansaranrom Hospital, Methods.– Data from 3,830 students in 16 schools, who asked for
Academic Office, Surat Thani, Thailand; 8 Suansaranrom Hospital, counselling over the period 1999 – 2018, were collected and pro-
Pharrmacist Office, Surat Thani, Thailand; 9 Suansaranrom Hospital, cessed.
Social Worker Office, Surat Thani, Thailand; 10 Suansaranrom Results.– Analysis of the data showed a significant change in the
Hospital, Nursing Offfice, Surat Thani, Thailand requests for counselling, after the beginning of the economic crisis.
* Corresponding author. More specifically, the requests concerned: 1. The effects of intense
and prolonged conflicts of parents on the psychosocial adaptation
Background and aims.– of adolescents. 2. Domestic violence (abusive parent with coexis-
Introduction.– The Satisfaction and Well-being in Senior scale (SWE) tence of alcoholism or psychopathology). 3. Anxiety disorders and
has been developed and demonstrated acceptable content validity. depressive symptoms. 4. The difficulties resulting from the conse-
Objective.– This study aimed at studying the construct validity and quences of the crisis in their lives (significant reduction in family
reliability of the scale among community-dwelling older people. expenses, deterioration of their living standards, loss of work by one
Methods.– Six-hundred elderly Thais (aged 60 years and older) or both parents). 5. Bullying (verbal violence, isolation/exclusion
who were not either depressed or cognitively impaired completed from school activities and community). 6. The problematic use of
the SWE, a 55 item self-administered with 4 Likert type scale. internet. 7. Confusion as to professional orientation and fear of
Exploratory factor analysis and Rasch analysis were performed. unemployment.
Results.– Mean age was 69.4 years, 74.7% females, 57.3% had ele- Conclusions.– The results are consistent with surveys that relate
mentary level of education. Cronbach’s alpha was 0.96 for the whole socio-economic conditions to the increase of psychosocial health
scale, with 0.72–0.86 for each factor. Factor analysis yielded 9 fac- problems.
tors. The factor loadings initially ranged from 0.826 and 0.485. In Disclosure of interest.– The authors have not supplied a conflict of
refining the scale, 4 items per factors were selected to form a shorter interest statement.
version of SWE. The factor loadings are Enjoyment (0.630–0.601),
Resolution (0.650–.0513), Fortitude (0.681–0.485), Congruence
between desired and achieved goals (0.767–0.627), Positive self- E-PP0654
concept (0.826–0.679), Giving up authority (0.733–.0533), Mood Beliefs about the loss of valued life
tone (0.654–0.558), Reconciliation with others (0.679–0.584), Self-
goals associated with physical and
sufficiency (0.826–0.679). This 9- factor model explained 56.68% of
total variance. However, Rasch analysis endorsed unidimensional- mental impairments
ity rather than multi-dimensionality, Person Reliability = 0.92, and M. Iosifyan* , G. Arina, V. Nikolaeva
Item Reliability = 0.98. Moscow State University, Department of Psychology, Moscow, Russia
Conclusions.– SWE, a 9-factor solution, is consisting of 36 items with
excellent internal consistency. However, confirmatory factor anal- Background and aims.– Knowledge of the factors associated with
ysis should be carried out in new sample. Dimensionality of the stigmatization of people with mental illness has begun to accu-
scale should be further investigated to ensure whether subscale mulate, however, much remains to be known. For instance, it is
score can be used along with total score. Test-retest reliability and important to explore the beliefs towards people with mental illness.
concurrent validity with other tests should be further examined. The present study investigates how people associate the loss of
Disclosure of interest.– The authors have not supplied a conflict of valued life goals among persons with mental and physical impair-
interest statement. ments.
Methods.– Participants (N = 131, age range 19–45, 31 males, mean
age = 20) were presented with a list of impairments. Physical
impairments were superior and anterior paraplegia, while men-
tal impairments were inability to reason and mental disorder. The
participants were asked to select three valued life goals which
could be lost in the event of each of those health states. The
list of valued life goals consisted of Schwartz’s value dimen-
sions: openness to change (self-direction and stimulation values), Background and aims.–
conservation (security, conformity, tradition), self-enhancement Introduction.– In nursing science, establishing a relationship
(hedonism, achievement, power) and self-transcendence (benev- between the nurse and patient forms the core of care. There are
olence, universalism). some inhibiting factors for having appropriate communication
Results.– Physical impairments are stronger associated with the loss skills in providing services and cares for patients which influences
of openness to change values compared to mental impairments the relationship between nurse and patient.
(Z = 3.323, p = .001). People with mental impairments were seen as Objective.– The aim of this study was to determine the correlations
less having values of conformity (Z = 4.03, p < .0001). No differences between the communication skills and nurses’ schema in pediatric
in self-enhancement and self-transcendence values were found. units of 17 Shahrivar Educational-therapeutic center in Rasht city,
Conclusions.– Thus, people associate physical impairments with the 2016–17.
loss of the ability to perform independent action and readiness for Methods.– The current research is a descriptive analytical study of
new experience; while mental impairments are associated with correlation type. The study sample in this research included 146
loss of self-restriction, order and the reliability in relations with people of the nurses working in 17 Shahrivar pediatric hospital.
others. These associations might partially explain the stigmatiza- Samples were selected by census and completed the demographic
tion of people with mental illness. questionnaire, communication skills questionnaire and the early
Disclosure of interest.– The authors have not supplied a conflict of maladaptive scheme questionnaire of Yang. Data was analyzed
interest statement. using SPSS v.21 software and with the help of descriptive and
inferential statistics (Friedman test, independent test, ANOVA, and
Spearman).
E-PP0655 Results.– The highest scores balanced with the mean and stan-
Block joy no hangover: report of dard deviation in the public communication skills respectively
experience of health promotion in the were 4.12 ± 0.53 and in the disconnection/rejection domain scored
2.65 ± 1.04 (P < 0.001). The findings showed a significant and
carnival of Brazil
positive correlation between the communication skills and the
J.A. Jaber Filho1* , J. Verissimo Jr2 , A. Hollanda2 , P.C. Geraldes2
1 schemes of nurses. Based on the final regression model with con-
Clínica Jorge Jaber, Saúde Mental, Rio de Janeiro, Brazil; 2 Clínica
trol of personal schemes of impaired autonomy and performance
Jorge Jaber, Saúde Mental, Rio de Janeiro, Brazil
* Corresponding author. was considered as a factor associated with communication skills
(P = 0.002).
Background and aims.– Conclusions.– The correlation of the communication skills in nurses
Introduction.– The consumption of alcohol is a serious public health with schema indicated a reverse significant relationship meaning
problem in Brazil, as in other countries. Carnival is considered the nurses with higher scores in the schema had weaker communica-
most popular celebration in Brazil. In the days of revelry, millions tion skills.
of people across the country take to the streets in search of fun. Disclosure of interest.– The authors have not supplied a conflict of
In this period, there is an increase in alcohol consumption, conduct interest statement.
considered by many individuals as admissible, because it is a festivo
period.
Methods.– E-PP0657
Methodology.– Regarding the problem of alcohol and drugs during A proposed model for occupational
the carnival, the Psychiatrist Jorge Jaber, aims to show that it is mental health advocacy and disability
possible to have fun without drinking alcohol and other drugs.. All prevention
come together in an atmosphere of joy and relaxation, rocked by K. Laxton
music and carnival disclosing the harm of alcohol consumption. University of Stellenbosch, Department of Psychiatry, Cape Town,
Results.– Block parades every year during the carnival at Copaca- South Africa
bana beach, in the city of Rio de Janeiro, gathering a crowd of people,
and organized groups of society who fight for the anti-drug cause Background and aims.– By 2020 Depression will be the leading
Conclusions.– The block “Hangover Without Joy” works with health cause for global disability according to the WHO. South Africa is
promotion, working at the level of primary prevention. This relates experiencing an increase in applications for temporary and/or per-
to the conceptual formulation of health promotion, as seen action manent disability on Mental and Behavioural grounds. Depression
on the individual, for their behavioral change and lifestyle. Thus, is believed to affect 1 in 4 persons within the working South African
the block and its proposal, intended to contribute to the change of context.
vision on the part of society that associates the carnival the con- The struggle to fight depression, improve quality of life and pre-
sumption of alcoholic beverages and drugs, showing the dangers of serve functioning is real and in need of critical review.
consuming these substances and proving that it is possible to enjoy The aim of this presentation is to provide a conceptual framework
the joy without alcohol or drugs. in which psychiatrists, insurers and workplace corporations may
Disclosure of interest.– The authors have not supplied a conflict of work together to advocate for mental health and ultimately pre-
interest statement. serve the functioning workforce.
Methods.– To provide a model to present to psychiatrists, insures
and employers, invested in mental health advocacy and disability
E-PP0656 prevention (Figure 1).
Survey the correlations between the
communication skills and nurses’
schema in pediatric units of 17
Shahrivar educational-therapeutic
centers in Rasht city, 2016–17
N. Lakeh
Guilan University of Medical Sciences, Nursing, Rasht, Iran
and self-esteem over time. A positive and fairly strong effect can be
attributed to Somatic-Psychoeducation on self-esteem and vulner-
ability to stress, subject to a sequence of at least 10 sessions. More
precisely we observe a joint action on anxiety trait and self-esteem
suggesting behavioural impacts. This opens up new perspectives for
body-mind techniques particularly in mental health promotion.
interest statement.
E-PP0659
Cultivating compassionate schools:
pilot study of a compassion focused
intervention to promote teachers’
Figure 1. Model for occupational mental health advocacy and dis- mental health and wellbeing
ability prevention. M. Matos1* , L. Palmeira1 , I. Albuquerque1 , M. Cunha1 , M. Pedroso
Lima1 , A. Galhardo1 , P. Gilbert2
Results.– This platform will hopefully allow for discussion and 1 Center for Research in Neuropsychology and Cognitive and
debate as to the foreseeable application and sustainability of such Behavioural Interventions CINEICC, University of Coimbra, Faculty of
a model. Psychology and Educational Sciences, Coimbra, Portugal; 2 University
Conclusions.– The quality of life and functioning of those who are of Derby, Centre for Compassion Research and Training, College of
susceptible to and/or those who have experienced a mental illness Health and Social Care Research Centre, Derby, United Kingdom
such as depression are fundamental components of mental health * Corresponding author.
management. The workplace is one such an environment that can
be a trigger for as well as a possible avenue of rehabilitation for Background and aims.– Growing research has supported the effi-
a person experiencing depression. It is critical that mental health cacy of mindfulness and compassion-based interventions in diverse
advocacy and promotion be actively incorporated into the occu- populations and contexts, particularly to the development of adap-
pational environment for both individuals and the economy as a tive emotional regulation skills central to the promotion of mental
whole. health and wellbeing. Teachers present a high risk of professional
Disclosure of interest.– The authors have not supplied a conflict of stress, which negatively impacts their mental health and profes-
interest statement. sional performance. In addition, there is a high prevalence of mental
health problems in the school context, involving both teachers and
students. Therefore it is crucial to promote adaptive cognitive and
E-PP0658 emotional processes that support teachers in dealing with the chal-
Somatic-psychoeducation, a lenges of the school context and promote their mental wellbeing.
psychocorporeal mental health This study aims at testing the effectiveness of the Compassionate
Schools Program, a six module compassionate mind training (CMT)
promotion tool group intervention for teachers to improve wellbeing and mental
A. Lieutaud* , K. Grenier, D. Bois
health.
Centre for Applied Studies and Research in Perceptual
Methods.– A pilot study was conducted in a sample of 41 teachers,
Psychoeducation CERAP, Fernando Pessoa University FPU, Porto,
employing a mixed-measures quantitative and qualitative design.
Portugal
* Corresponding author. Results.– Regarding qualitative assessment, the CMT intervention
was well received. Furthermore, results revealed that there were
Background and aims.– Answering a concern that anxiety and low significant decreases in depression, stress, and fears of compassion
self-esteem may interfere with long-term recovery or well-being to others, as well as significant increases in compassion to oth-
development, preventative approaches have been developed over ers, self-compassion, and compassionate motivations and actions
the past decades. Somatic-Psychoeducation is such an approach after the CMT intervention. When self-criticism was controlled for,
and focuses on the development of bodily self-perception. a decrease in burnout and an increase in satisfaction with teachers’
Exploratory studies show promising beneficial effects in various life were additionally found.
non-clinical populations. Conclusions.– As a pilot study, our results demonstrate the possible
A large scale study furthers this exploration and assesses Somatic- benefits of CMT in education settings and suggest that the Com-
Psychoeducation’s impacts on anxiety and self-esteem using passionate Schools intervention is effective to promote teachers’
standard self-reporting tools. mental health, wellbeing and emotion regulation skills.
Methods.– A longitudinal observational multicentre survey was Disclosure of interest.– The authors have not supplied a conflict of
conducted in the field. 114 participants were recruited by 25 prac- interest statement.
titioners. Anxiety and self-esteem scales (STAI-Y and SES-10) were
completed before and after the sessions at three stages of a 10-
E-PP0660
session sequence: first, fifth and last sessions.
Results.– 76 participants completed the protocol, mostly women Current status of micronutrient
(88.2%) aged 51 ± 12. The ANOVA, Fisher and Student t Test con- research in psychiatry for promotion
ducted show strong and significant (p ≥ 0.001) changes in anxiety of mental health
state before/after the session at all stages (-13pts on average, corre- L. Mehl-Madrona1* , P. McFarlane2 , B. Mainguy3
sponding to a 32% decrease, 2 > 0.6), and in anxiety trait (-6.4pts, 1 University of Maine, Graduate School, Orono, Maine, USA; 2
13% decrease, 2 = 0.51) and self-esteem (+3.89pts, 13% increase, University of New England, Family Medicine, Bangor, USA; 3
2 = 0.67) over the completed program. There was no detectable University of Maine at Orono, School of Social Work, Orono, USA
practitioner effect (F < 1.2). * Corresponding author.
Conclusions.– Intervention has a positive and consistent immedi-
ate effect on anxiety state and positively influences anxiety trait
Background and aims.– Optimal nutrition and even super-saturation show us where to go next, and how useful young people think this
of enzymes with cofactors has been proposed to be relevant for project is.
mental health. Increasing cofactor concentration has the affect Disclosure of interest.– The authors have not supplied a conflict of
of shifting the Michaelis-Menton coefficient such that inefficient interest statement.
enzymes can become efficient. A literature has begun to develop on
the use of high-dose, high-potency micronutrients in psychiatric
conditions. Previous research by the authors has shown equiv- E-PP0662
alence of high potency, high dose micronutrients to risperidone Anger and anger expression styles in
for behavioral symptoms of autism and that patients with psy- nurses
chosis can function well on statistically significantly lower doses of N. Çetin1 , F. Oflaz2*
medication than their counterparts who are not receiving micronu- 1 Health Sciences University Sultan Abdulhamit Han Hospital,
trients. This presentation presents the results of an open label Nursing Dept., Istanbul, Turkey; 2 Koç University, School of Nursing,
clinical trial and describes an ongoing double-blind, randomized Istanbul, Turkey
controlled trial for bipolar disorder. * Corresponding author.
Methods.– Patients with confirmed bipolar disorder at a rural pri-
mary care clinic in Northern New England, USA, were offered the Background and aims.– The anger and expression of nurses are an
opportunity to participate in a study of micronutrient supple- important issue in terms of individual and work environment. Con-
mentation to their standard care. Patients joining the trial were trol of anger depends on the definition of anger and knowing how
compared to all other patients in the clinic. A composite z-score it is triggered.
was calculated based upon medication reduction, clinical global The aim of this study was to determine the factors affecting the
impression (CGI) ratings, and side effects experienced. anger of nurses and to investigate the relationship between these
Results.– Patients on micronutrients scored statistically signifi- factors and their anger.
cantly better on their composite z-scores than the comparison Methods.– This cross-sectional study was conducted with 319
population. Medication doses were lowered on average with fewer nurses who had no psychiatric diagnosis and volunteered to partic-
side effects and better CGI scores. This led to the design of a double- ipate into the study from two education and research hospitals in
blinded, randomized, controlled trial which is now ongoing. Istanbul in 2017. The data were collected by Personal Information
Conclusions.– Supplementation with micronutrients (including Questionnaire and Trait Anger - Anger Expression Scale.
omega-3 fatty acids) may allow improved functioning with bet- Results.– According to the findings, the level of trait anger in nurses
ter quality of life and fewer side effects for patients with bipolar was on the middle level. They were keeping it inside rather than
disorder. expressing, and they were feel that successful in anger manage-
Disclosure of interest.– The authors have not supplied a conflict of ment. The nurses with undergraduate degrees had higher “trait
interest statement. anger” than the nurses with other degrees; additionally, those
who had a balanced income level and those with children had
lower trait anger, and they more rarely expressed it. Married ones
E-PP0661 express their anger less than single ones. Nurses consider some sit-
Babytalks - talking to teenagers about uations as source of anger, such as “non-compliance to the rules by
babies! patients’ relatives”, “working with insufficient equipment”, “being
S. Neiva1* , R. Gonçalves1 , P. Caldeira da Silva2 responsible for a large number of patients at the same time”,
1 Pediatric Hospital, Coimbra Hospital and University Center CHUC, “underestimating what they do”, in the work environment.
Child and Adolescent Psychiatry Department, Coimbra, Portugal; 2 Conclusions.– It was found that nurses seemed aware of how they
Hospital Dona Estefânia, Centro Hospitalar Lisboa Central, Centro de coping with their anger and how express their anger correctly.
Estudos do Bebé e da Criança, Chief of Service Unidade de Primeira Disclosure of interest.– The authors have not supplied a conflict of
Infância, Lisboa, Portugal interest statement.
Background and aims.– The BabyTalk project was created in 2015 at E-PP0663
the Unidade de Primeira Infância, Department of Child and Adoles- Making sense of suicide-related
cent Psychiatry, Dona Estefânia Hospital in Lisbon. This project aims knowledge and skills in a sample of
to sensitize teenagers at their last year of college (ages between 17
health professionals and students
and 18 years) about early childhood and parenthood.
M. Pompili1* , D. Erbuto2 , S. Sarubbi3 , E. Rogante3 , M. Migliorati4 ,
Talking about being a parent, emotional, cognitive and relational
M. Innamorati5
needs of the infants has becomed a necessity when youth no longer 1 Sapienza University of, Dept. of Neurosciences, Mental Health and
contact with babies and small children in their daily-life. With the
Sensory Organs. Suicide Prevention Center, Sant’Andrea Hospital-
changes in society, families tend to be smaller and isolated, spe-
Sapienza University of Rome, Roma, Italy; 2 Sapienza University of
cially at big cities. This way, adolescents no longer contact with
Rome, Dept. of Neurosciences, Mental Health and Sensory Organs.
smaller children growing up and rising a child is no longer intuitive
Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University
and modulated between generations.
of Rome, Italy, Roma, Italy; 3 Sapienza University of Rome,
Methods.– The program consists of a 45 minutes presentation. After
Department of Psychology, Rome, Italy; 4 Sapienza University of
that they where asked to answer an anonymous questionnaire
Rome, Dept. of Neurosciences, Mental Health and Sensory Organs.
about: What they think of the subject? What do they want to know
Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University
more? At what age do they want to became parents?
of Rome, Rome, Italy; 5 European University of Rome, Department of
Results.– Since the data collection is currently ongoing, the authors
Human Sciences, Rome, Italy
will only be able to provide final results and conclusions by the time * Corresponding author.
of submission of our work presentation.
Conclusions.– Experts have already shown all the potencial and ben- Background and aims.– To examine the association between gate-
efit of intervention and investment on early childhood. keeper training and suicide-related knowledge among a diverse
This project intends to create awareness and to promote mental set of health care workers (psychiatrists, nurses, psychologists,
health, by investing in adolescents who are in a privileged position and educators) and students enrolled in medical and psychological
as future parents and policy-makers. The analises of the data might
schools who took part in the International Symposium on Suicidol- E-PP0665

ogy and Public Health 2015-2017 conferences. Stigma in morocco: where
Methods.– 670 (511 women) health care workers (psychologists
commitment meets controversy
> psychiatrists > nurses > educators > Other) and students were
K. Touzani
administered the Suicide Knowledge and Skills Questionnaire
Complutense University of Madrid, Department of Psychology,
(SNSQ; Smith et al., 2014), a 13-item survey questionnaire assess-
Madrid, Spain
ing participants’ knowledge about suicidal behavior and comfort * Corresponding author.
dealing with suicidal clients.
Results.– 44.5% of health care workers who gave a valid answer Background and aims.– During these last decades, stigma has been a
reported a past patient suicide behavior (psychiatrists > educa- major issue in the field of mental illness. It holds prejudice, stereo-
tors > nurses > psychologists > others). In 67.5% of the times, the typical views, and leads to marginalization. Today, the field of
suicide behavior occurred in a setting other than the psychiatric mental health encompasses a variety of therapies and health pro-
department (22.1%) or a private setting (10.1%). Health care work- grams with the goal of reducing the causes of stigma. However,
ers who reported a suicide among their patients reported negative felt stigma creates a deep reluctance in patients towards seeking
consequences (anger > guilty feelings > poor self-esteem) from hav- mental health care and results in failed treatment adherence.
ing experienced a suicide among their patients. Around 30% of the The purpose of the study is to determine the components of Stigma
health care workers reported to be confident in their skills (32.9%), and identify the views on mental illness in Morocco. We will high-
training (28.4%), or support/supervision they receive (29.4%) when light the existing controversy between the views of the persons
treating a patient at risk of suicide. with mental illness and those of their familiy members. Moreover,
Conclusions.– Suicide assessment knowledge should be part of con- we will seek to understand what factors are affected by the stigma
tinuing education activities of health care professionals as well as regarding mental disorders.
be part of education curricula of students of medical and psycholog- Methods.– Observational design with Clinical Case Series.
ical schools. Differences exist between analyzed groups, which may Perspectives.– Statistical; Research Method: Quantitative
help in tailoring suicide prevention education in different settings. Data Collection.– Standardized Close-ended Questionnaires, Tools,
Disclosure of interest.– The authors have not supplied a conflict of Surveys
interest statement. Data Analysis.–
Statistical.– Correlation, Regression Analysis Methods
Results.– We expect a high level of correlation between the stigma
E-PP0664 felt by people diagnosed with mental illness who will endorse neg-
Help-seeking in the young adult ative stereotypes. Caregivers and familiy members are expected to
community have affiliate stigma which will diminish with time.
F. Schultze-Lutter1* , C. Michel2 , N. Schnyder2 , S.J. Schmidt3 , B.G. Conclusions.– We expect high levels of internalized-stigma and
Schimmelmann2 significant maladaptive coping strategies resulting in secrecy and
1 Heinrich-Heine University- Medical Faculty, Department of avoidance. The feeling of self-efficacy will be reduced, whereas
Psychiatry and Psychotherapy, Düsseldorf, Germany; 2 University of self esteem should be maintained due to family and peer sup-
Bern, University Hospital of Child and Adolescent Psychiatry, Bern, port. Furthermore, family members are expected to have distorted
Switzerland; 3 University of Bern, Department of Clinical Psychology cognitions regarding their relatives’ mental state due to lack of
and Psychotherapy, Bern, Switzerland information on mental illness.
interest statement.
Background and aims.– Missing or delayed help-seeking has been
repeatedly associated with negative outcome of mental disorders.
Insufficient knowledge about mental disorders and their treat- E-PP0666
ment, i.e., insufficient mental health literacy, as well as negative Long-term mental health effects of
attitudes towards persons with mental disorders and, more impor-
mindfulness training: a 4-year
tantly, towards mental health services were reported to contribute
to delayed help-seeking. We examined (I) the clinical predictors follow-up of an RCT in medical and
of help-seeking for mental problems; (II) the differential influence psychology students
of type of stigma and causal models of mental disorders on help- R. Tyssen1* , I. Solhaug2 , M. de Vibe3 , O. Friborg4 , J.H. Rosenvinge4 ,
seeking for mental disorders; and (III) self-reported reasons for T. Sørlie5 , A. Bjørndal6
1 University of Oslo, Dept of Behavioural Sciences in Medicine, Oslo,
delays in help-seeking in the community.
Methods.– Analysing cross-sectional data of the Bern Epidemio- Norway; 2 Faculty of Health Sciences, The Arctic University of
logical At-Risk (BEAR) study (baseline: N = 2683, age 16–40 years, Norway/University of Tromsø, Department of Psychology, Tromsø,
response rate: 63.4%) assessed in a telephone survey by well- Norway; 3 Norwegian Knowledge Center for the Health Services,
trained clinical psychologists. Norwegian Knowledge Center for the Health Services, Oslo, Norway; 4
Results.– Structural equation modelling revealed that functional Faculty of Health Sciences- University of Tromsø, Department of
deficits as well as a psychosocial causal model of mental disorders Psychology, Tromsø, Norway; 5 Faculty of Health Sciences, University
and positive attitude towards help-seeking were positively asso- of Tromsø, Department of Clinical Medicine, Tromsø, Norway; 6
ciated with help-seeking. Main reasons for delaying help-seeking Centre for Child and Adolescent Mental Health- Eastern and Southern
were hope for spontaneous remission and the consideration of Norway, Centre for Child and Adolescent Mental Health, Oslo, Norway
problems as not serious.
Conclusions.– The results will be discussed in relation to each other
Background and aims.– Both individual and organizational interven-
and with regard to their implications for the design of campaigns
tions are needed to enhance well-being, counteract burnout and
to promote earlier help-seeking.
ensure performance in young health professionals. Mindfulness-
Based Stress Reduction (MBSR) enhances short-term psychological
interest statement.
health, whereas studies examining long-term effects and possible
psychological mechanisms are scarce.
Methods.– In a two-site randomized controlled trial, 288 medical lists several recommendations for contending with the problems
and psychology students were allocated to a 7-week MBSR inter- that might arise in the course of the reform’s implementation
vention (n = 144) or a control group (n = 144). During follow-up the Disclosure of interest.– The authors have not supplied a conflict of
MBSR group was offered 90-min booster sessions semi-annually. interest statement.
Primary outcome measures included mental distress (GHQ-12) and
subjective well-being (4 items) at baseline and 1 month, 2 years,
and 4 years post-intervention. Secondary outcomes included cop- E-PP0668
ing (Ways of coping checklist), mindfulness (Five Facet Mindfulness RE-audit of capacity and consent in
Questionnaire), and meditation practice. Effects were studied by community treatment orders (CTOs)
mixed-model repeated measures. Mediation effects of secondary
in Derbyshire healthcare NHS
outcomes were also studied.
Results.– Drop-out rates after baseline were 3%, 19%, 32% respec- Foundation Trust
tively. At 4-year follow up, MBSR significantly reduced mental S. Bhattacharya* , R. Gupta, K. Taylor, C. Field
distress and avoidance coping, and it enhanced mindfulness and Derbyshire Healthcare NHS foundation Trust, Psychiatry, Chesterfield,
problem-focused coping (Cohen’s d = 0.23–0.42). Meditation prac- United Kingdom
tice predicted long-term mindfulness scores. Short-term effects
in mindfulness-scores and problem-focused coping mediated Background and aims.– Community treatment orders were intro-
long-term intervention effects on mental distress. Small post- duced in United Kingdom in 2007 to provide supervised treatment
intervention effects on subjective well-being and seeking social in the community. It means that patients can be treated in the
support did not persist at follow up. community but the responsible clinician can return the patient to
Conclusions.– MBSR fostered enduring long-term effects on mental hospital and give immediate treatment if necessary. It is of utmost
distress, active coping and mindfulness in this non-clinical sam- importance that CTOs get documented as per guidance in the MHA
ple of medical and psychology students. The secondary outcomes code of practice in UK.
coping and mindfulness may represent important psychological An audit was conducted in 2016 to assess the compliance of docu-
mechanisms of mindfulness training. The intervention effect-sizes mentaton. It was found falling short of the standards.A template
were small to almost medium in this long and relatively represen- was created in the electronic patient record system to stream-
tative follow-up. line the process of documentation and re-audit was conducted in
Disclosure of interest.– The authors have not supplied a conflict of 2018 to ascertain the extent of change in practice. The re-audit
interest statement. also endeavoured to look into the overall care delivered to patients
under CTOs.
Methods.– Records of all patients on CTOs in Derbyshire were
E-Poster Presentation: Mental Health Policies reviewed by looking into the template in the electronic patient
record system. Retrospective review of care documentation and
case notes were carried out to determine the frequency of review
by medic, cpc and safety plan updating.
E-PP0667
Results.– The trust reached 40% mark when it comes to documen-
Mental health reform: lessons from tation of CTOs and well above 90% when it comes to review by
the Israeli experience care-co-ordinators.
U. Aviram Some concerns were noted when it comes to frequency of review by
Hebrew University of Jerusalem, School of Social Work and Social medic and safety plan documentation as almost one-third patients
Welfare, Jerusalem, Israel were falling short in these respects.
Conclusions.– It was decided that findings of this audit will be dis-
seminated within the community consultants to influence change
of practice and a system was developed to notify the consultants
Introduction.– In July 2015, the mental health reform of Israel went
whenever they will receive the CTO form.
into effect, transferring responsibility for hospital and ambulatory
mental health services from government to the community health
interest statement.
maintenance organizations (HMOs) and integrating mental health
services into the main health care system. It concluded fifty years of
Israel’s attempts to achieve this major policy change- moving the E-PP0669
locus of mental health services from psychiatric hospitals system
to the community.
National program reform of mental
Objectives.– This paper examines the opportunities and challenges health care in Poland. Pilot study
associated with implementation of this reform and comments on A. Cechnicki1* , J. Wciórka2 , M. Balicki3
1 Chair of Psychiatry Jagiellonian University Medical College,
lessons other jurisdictions interested in reforming their mental
health service system could learn from the Israeli experience. Department of Community Psychiatry, Kraków, Poland; 2 Psychiatry
Methods.– The study was of the exploratory and “formative” assess- and Neurology Institute, 1st Psychiatry Clinic, Warszawa, Poland; 3
ment type – an evaluation in the course of program implementation Psychiatry and Neurology Institute, Pilot Study Office, Warszawa,
with the objective of improving functioning and outcome of the Poland
program. It relied on quantitative and interview-based qualitative
data. Interviewees, represented various organizations and interest
Background and aims.– Reform of Polish psychiatry started in 1972
groups, connected to the reform’s decision and its implementation.
and unfortunately stopped a few years later. It was not before 1994
Results.– The paper describes the principles and details of the
when the Mental Health Act was passed assuring due rights to
reform, analyzes the system prior to the reform and assesses the
patients, but not regulating transformation from the large hospital-
issues that remained unresolved and should be dealt with following
based treatment model to the community model. Subsequent legal
implementation
act in 2008 provided a statutory basis for the National Programme
Conclusions.– In conclusion, the papers reviews and assess key fac-
of Mental Health Care (NPoMHC).
tors that had been necessary for the reform to be decided upon. It
First edition of NPoMHC for the years 2011–2015 was implemented E-PP0671
merely in 10%, and only the second edition of NPoMHC for the years Neo-liberalising mental health in
2017–2022 made it possible to prepare a three-year pilot project
France: studying the official French
in 29 selected regions in Poland.
Methods.– The most important task of the programme is to establish texts on mental health since 2005
Mental Health Centers (MHC) that provide comprehensive psychi- D. Lampropoulos, A. Thémis
atric care (emergency, outpatient services, home treatment, day Aix-Marseille University, Laboratoire de Psychologie Sociale EA849,
treatment and hospital care) for adult population living in the area Aix-en-Provence, France
from 50 to 200 thousand inhabitants.
Results.– The pilot project will cover around 3 million (8%) of Background and aims.– Research has shown that mental health-
Poland’s population. According to the experts, a gradual shift from care policies aimed at achieving autonomy and integration for
the ‘large hospital’ to community psychiatry model remains in line people with mental disorders, through a community-based sys-
with the directions of mental health reforms observed in developed tem, have been developing all over the word. Critics working from
countries, as well as with the guidelines proposed by the EPA. a governmentality perspective have argued that these changes
Conclusions.– Polish Ministry of Health has ensured that ‘the are associated with technologies named as “advanced liberal”. In
improvement of the situation in mental health care is considered France however, there is no systematic work on this development.
a priority.’ Polish National Health Fund plans to increase expendi- In this study, we have analysed the main texts published by the
ture on mental health care because at present it amounts to 3,4% French Ministry of Health since 2005, in order to explore the evo-
of the total healthcare budget and remains far behind the average lution of discourses on citizenship and identify whether there is
expenditure in other European countries. an application of “advanced liberal” discourses and technologies in
Disclosure of interest.– The authors have not supplied a conflict of mental health planning.
interest statement. Methods.– A mixture of inductive thematic analysis and critical dis-
course analysis have been applied to the corpus, in relation to our
objectives.
E-PP0670
Results.– Our analysis has shown a clear transition from the national
Mental health law in Russia towards a territorial, local planning, and what has been called
G. Kostyuk1* , O. Karpenko2 , A. Masyakin1 , L. Burygina3 “government through community”. Furthermore, the objectives of
1 Mental Clinic No1 named after N.A. Alexeev, Administration, autonomisation, responsibilisation and self-management of users
Moscow, Russia; 2 Mental Clinic No1 named after N.A. Alexeev, have become increasingly central, in a context in which mental
Education Center, Moscow, Russia; 3 Mental Clinic No4 named after health is presented in a de-socialized way, followed by recognition
P.B. Gannushkin, Administration, Moscow, Russia of users’ rights and social inclusion and the fight against the stigma
of mental disorders.
Conclusions.– We conclude by arguing for the need for empirical
Background and aims.– Both the absence and presence of mental
research that identifies tensions in discourses and practices in the
health legislation present risks for people with mental disorders.
field, where mental health policies are translated into mental health
Most recently, the UN special rapporteur on disability has decreed
projects and practice.
that all mental health specific legislation leading to restriction is
discriminatory. On the other hand, up-to-date research data sug-
interest statement.
gest that, for example, duration of untreated psychosis should
be as short as possible to prevent neurological damage and its
consequences. Therefore, mental health legislation might weight E-PP0672
carefully the ratio between rights of patients and the specificity of
mental disorders known for the lack of disease awareness. The pre- Characterization of the compulsory
sentation will focus on mental health law in Russia as an example treatments initiated from 2012 to
of ethical challenge solution. 2017 in the Évora Hospital - Portugal
Methods.– The historical background of mental health law creation A.L. Melo* , F. Godinho, S. Marques, J. Pedro, M. Serra
and the critical analysis of its strengths and weaknesses will be Hospital do Espírito Santo de Évora, Psychiatry and Mental Health
presented. Department, Évora, Portugal
Results.– mental health law in Russia was introduced in 1992 and * Corresponding author.
has a status of federal act. Special attention is payed to terms

of mental care provision especially involuntary care, which can Background and aims.– Data regarding admissions under the Por-
be implemented only upon court order and the decision of three tuguese Mental Health Act are scarce, even though, by interfering
psychiatrists’ commission. Patients, their relatives and defense with a basic human right - freedom - their detailed characterization
attorney can take part in the court session. Only psychiatrists have should be an integral part of the analysis of care provided by any
the right to diagnose and treat mental disorders, this article of the psychiatric service.
law nowadays leads to difficulties in the involvement of general We aim to analyse the sociodemographic and clinical-legal char-
practitioners in the treatment of common mental disorders. acteristics of individuals who initiated Compulsory Treatment (CT)
Conclusions.– mental health legislation in Russia protect people between 01/01/2012 and 31/12/2017, in the Department of Psy-
with mental disorders from the detriment to their human rights; chiatry and Mental Health of Hospital do Espírito Santo de Évora,
further efforts should be done to achieve the parity between phys- which serves about 160000 inhabitants.
ical and mental health. Methods.– Retrospective study of the clinical/judicial records. We
Disclosure of interest.– The authors have not supplied a conflict of collected a sample of 291 CT, corresponding to 228 individuals. Data
®
interest statement. gathered and analysed in Excel .
Results.– From a sociodemographic analyses, individuals were
predominantly male, single, in the 26-45 age range, retired or
unemployed and living with parents and/or siblings. From a
clinical-legal analyses, the percentage of Compulsory Admissions
(CA) per year ranged from 9.7–25.9% and the CA rate per 100000
inhabitants from 24.4–40.2; the majority of patients had psychi-
atry consultations and/or previous psychiatry admissions and the E-PP0674

most frequent diagnoses were Schizophrenia and Bipolar Disor- Psychiatry in transition: exemplar
der; on half of the occasions, they were escorted to the emergency
case studies from Italy and Bulgaria
department under an assessment warrant; altered behaviour was
D. Stoyanov1* , S. Galderisi2
what mostly motivated the admission, the majority of which
Medical University, Psychiatry and Medical Psychology, Plovdiv,
lasted between 2–4 weeks; 8.2% of the CT were continued on
Bulgaria; 2 University of Campania “Luigi Vanvitelli”, Psychiatry,
an out-patient basis - these individuals were mostly males with
Naples, Italy
Schizophrenia. * Corresponding author.
Conclusions.– Considering the future must be built on an analysis of
the past and present, we intend to reflect on these data and evaluate Background and aims.– After suffering the long term consequences
the need to rethink action/intervention plans. of institutionalized care of the asylum psychiatry and following the
Disclosure of interest.– The authors have not supplied a conflict of introduction of modern treatment and rehabilitation technologies
interest statement. in the second half of the XX century there were attempts for reform-
ing psychiatric systems by introducing of new, complex and more
humane forms of mental health care delivery.
E-PP0673 This report will explore the comparative experiences from periods
Involuntary commitment to an of transition in two South European counties and will draw per-
inpatient service in Portugal - spectives on the possible improvement of the psychiatric services.
sociodemographic and clinical Methods.– Methods of historical reconstruction and public health
analysis were employed.
characterization of patients admitted Results.– The reform of mental health care in Italy started with
in 2017 the Mental Health Care Act in 1978 and triggered a 25 years
B. Moura* , T. Rodrigues, P. Horta, A. Samico, A.T. Pereira, Â. of period in transition from hospital based to community based
Venâncio, R. Ribeiro Silva, M. Araújo, G. Lapa mental health care. It has been subjected to controversial commen-
Centro Hospitalar Vila Nova de Gaia/Espinho, Department of taries due to concerns about the overall social and public health
Psychiatry and Mental Health, Vila Nova de Gaia, Portugal impact. Attempts for reform in Bulgarian psychiatry started in
1996–2002 with political declarations for de-institutionalization.
In result however it achieved a reduction of hospital beds without
Background and aims.– In Portugal, Involuntary Commitment is
establishing any effective alternative model of community system.
an exceptional measure, reserved for patients with severe men-
No separate Mental Health Care Act has been introduced on the
tal illness who refuse treatment and pose danger to themselves
legislative level. As a consequence psychiatry in Bulgaria has been
or others, established by the Mental Health Law of 1998. Mental
heavily marginalized from the health and social care systems and
Health Services have started to prioritize community-based ser-
lacks adequate human and funding resources.
vices, in detriment of institutionalization. This contrasts with the
Conclusions.– The described models of transition suffer from dif-
increase of involuntary admissions in the majority of European
ferent shortcomings. New model for reform in psychiatric care is
countries. In Portugal, the amount of data is scarce, and limited
called for in countries from South European region.
to few epidemiological studies.
We aim to establish the sociodemographic and clinical characteri-
interest statement.
zation of patients admitted involuntarily to an inpatient service in
Vila Nova de Gaia (Portugal).
Methods.– We conducted a descriptive analysis of all patients E-PP0675
admitted involuntarily in the year 2017 and a non systematic
review of literature. Recommendations for mental health
Results.– In 2017, we had 203 involuntary admissions. Most were service users’ and carers’
male (60,6%), aged less than 54 years (84,7%), non married (68,5%), empowerment in mental health: a
with up to 12 years of schooling (65,5%) and currently unemployed participatory research
(42,4%) or receiving a disability pension (23,2%). The majority was S. Vasseur-Bacle* , A. Dannet, B. de Rosario, J.B. Hazo, D. Sebbane,
already accompanied in outpatient services (73,9%) and had history J.L. Roelandt
of prior admissions (55,2%). The main cause for admission was psy- WHO Collaborating Centre for Research and Training in Mental
chosis (51,2%), and the most frequent diagnoses at discharge were Health, CCOMS Lille, Hellemmes, France
schizophrenia, schizotypal and delusional disorders (51,7%). * Corresponding author.
Conclusions.– The sociodemographic profile of patients in our sam-
ple is aligned with previous findings at a national and european Background and aims.– The French WHO collaborating centre for
level. Most were admitted for psychotic disorders, but also for mood mental health research and training organized two international
disorders, personality disorders, dementia, and mental retarda- congresses, in 2014 and 2018, that have gathered 400 and 650
tion. Further studies are needed to characterize patients commited participants. Both congresses were dedicated to empowerment of
involuntarily and to assess their needs in terms of treatment and users in mental health, with a special focus on e-mental health for
social integration. the second one.
Disclosure of interest.– The authors have not supplied a conflict of During them, we solicited stakeholders (users, carers, health pro-
interest statement. fessionals, policy-makers and researchers) in order to draw a list of
prioritized recommendations for empowerment of users and carers
in mental health care and research.
Methods.– During the first congress, recommendations were col-
lected from speakers and participants. These recommendations
were grouped and reformulated through an iterative process with
stakeholders panel and focus groups.
In 2018 congress, recommendations were also asked to every
speaker and participant. They were categorized into the rec-
ommendations of 2014 or new ones when necessary by three E-PP0677

independent researchers. Emotional isolation moderates social
The list of recommendations was finally sent to all participants of
emotional gain in the everyday life of
both congresses and other international stakeholders for a prior-
itization survey based on the feasibility and importance of each
non-european migrants living in
recommendation. Germany: an ecological momentary
Results.– The first process collected 200 material from stakeholders assessment pilot study
that ended up in a list of 21 recommendations covering three areas: T. Ebalu1* , G. Gan1 , M. Reichert2 , U. Braun1 , R. Ma1 , T. Kremer1 , O.
Protection of Human Rights; Participation in the organization and Berhe1 , A. Zipf3 , U.W. Ebner-Priemer2 , A. Meyer-Lindenberg1 , T.
evaluation of services; Information and communication. Gaps of Heike1
priorities for each kind of stakeholder arose. 1 Central Institute of Mental Health/Medical Faculty of the University
Coding and prioritization of the recommendations from the 2018 of Heidelberg, Systemic Neuroscience in Psychiatry/Department of
congress is on-going but results will be ready for EPA 2019. Psychiatry and Psychotherapy, Mannheim, Germany; 2 Karlsruhe
Conclusions.– Even though empowerment of users and carers is a Institute of Technology, Mental mHealth Lab, Chair of Applied
common claim, its implementation needs practical recommenda- Psychology- Department of Sports and Sports Science, Karlsruhe,
tions built and approved by them. Germany; 3 Institute of Geography, Heidelberg University, GIScience
Disclosure of interest.– The authors have not supplied a conflict of Research Group, Heidelberg, Germany
Background and aims.– Humans are hardwired to form social

connections and depend on vital emotional support from social
E-Poster Presentation: Migration and Mental networks. However, visible minorities (i.e., migrants) may have
health of Immigrants difficulties in establishing these connections with the majority pop-
ulation, and consequently feel emotionally isolated (i.e., lack of
intimate relationships). Feeling emotionally isolated can thus hin-
der emotional well-being (i.e., valence). In a pilot study, we used
E-PP0676
Smartphone-based Ecological Momentary Assessment (EMA) to
Mental health need and psychiatric investigate whether the effect of social contact on valence in real
service utilisation of Syrian refugee life, i.e., social emotional gain, is moderated by emotional isolation
children in Turkey in non-European migrants.
V. Çeri* , E. Fadiloglu, C. Beşer, A. Arman, N.P. Fiş Methods.– Across 7 days, 39 participants (22 German; 17 Migrants,
Marmara University- School of Medicine, Child and Adolescent 19 males, age: 20 ± 4) rated their valence (well/unwell, satis-
Psychiatry, Istanbul, Turkey fied/not satisfied), and reported on social contact (in company vs.
* Corresponding author. alone) on Smartphone e-diaries (9-24 prompts/day). Additionally,
the UCLA Loneliness scale assessed emotional isolation.
Background and aims.– Turkey which hosting one out of every 8 Results.– Participants were matched in age, gender, and socio-
refugees has been the leading refugee hosting country since 2014. economic status. A multilevel model analysis showed that higher
Despite Studies which carried out with refugee children in Turkey emotional isolation was associated with lower valence across both
revealed that one out of every two refugee children have at least groups (p = 0.02). Next, being in the company of others compared to
one psychiatric disorder, We have no data on psychiatric service being alone increased valence within persons across both groups
utilisation of refugee children in Turkey. (p < 0.001). Furthermore, migrants, but not Germans, with lower
Methods.– The study was carried out at the Refugee Mental Health compared to higher emotional isolation showed a stronger social
Unit of Marmara University Child Psychiatry Department in Istan- emotional benefit, i.e., a higher difference of valence between being
bul. The files of all Syrian refugee children who admitted to the in the company of others and being alone (p = 0.01).
unit during the 1-year period were retrospectively evaluated. Find- Conclusions.– Our findings suggest that social contact is important
ings of refugee children were compared with findings of Turkish in fostering emotional well-being in daily social interactions, and
children. The groups were matched for age and gender. this may be especially important for visible minorities (migrants)
Results.– 66 children and adolescents have admitted to our service who are prone to discriminatory experiences.
for psychiatric evaluation during the period. Of these individuals, Disclosure of interest.– The authors have not supplied a conflict of
34.8% (n = 23) were females and 65,2% were males (n = 43). Mean interest statement.
age of our sample was 8.7 (18 months to 17 years). Attention
Deficit/Hyperactivity Disorder (34.8%), Major Depression (25.8%),
and PTSD (21.2%) were the most common disorders among refugee E-PP0678
children. Psychiatric service utilization increased dramatically after Interdisciplinary treatment and
opening of the specialized child psychiatry unit for refugees
complex rehabilitation of internally
Conclusions.– Our findings showed that refugee children are suffer-
ing from a broad spectrum of psychiatric disorders which requires displaced persons with comorbid
ongoing psychiatric care. It also revealed that specialized child psy- menthal and somatic disorders
chiatry units might increase utilization of mental health services by V. Korostiy1* , H. Kozhyna2 , O. Platynuk2
1 Kharkiv National Medical University, Psychiatry- Narcology and
refugee children.
Disclosure of interest.– The authors have not supplied a conflict of Medical Psychology, Kharkiv, Ukraine; 2 Kharkiv National Medical
interest statement. University, Psychiatry Narcology and Medical Psychology, Kharkiv,
Ukraine
Background and aims.– Screening of IDPs’ mental health who sought

medical help in somatic clinic (University clinic KhNMU) and esti-
mation of efficiency of interdisciplinary treatment and complex
rehabilitation.
In the University Clinic asked 156 people displaced from areas of cut-off values can only be interpreted with caution for these ethnic
Lugansk and Donetsk regions. Only 65 of them had official status groups.
of IDPs. Reasons treatment all patients were somatic complaints. Disclosure of interest.– The authors have not supplied a conflict of
In screening using the scale hospital all patients were found higher interest statement.
rates of anxiety and depression. 48% of patients abandoned psychi-
atric examination, even 24% of psychological counseling.
Methods.– Psychodiagnostical, clinical-psychological, clinical and E-PP0680
psychopathological. Exploring the association between
Results.– Clinical examination during the period of acute stress reac- migration and non-affective
tions was observed, dominated by anxiety disorders, prolonged
psychosis: a narrative review
depressive reaction. Anxiety disorders were found in 56.5%, pro-
D. Moura1,2* , S. Morais1,2 , N. Madeira1,2
longed depressive reaction in 32.0%, post-traumatic stress disorder 1 Centro Hospitalar e Universitário de Coimbra CHUC- Portugal,
in 10.5% of patients. Psychosomatic disorders were 80% of patients.
Department of Psychiatry, Coimbra, Portugal; 2 Faculty of Medicine-
The treatment of the underlying disease, complex psychological
University of Coimbra, Institute of Psychological Medicine, Coimbra,
and physical rehabilitation. Psychological rehabilitation included
Portugal
CBT, relaxation, art therapy. Physical rehabilitation includes kine- * Corresponding author.
siotherapy and TRE. A set of measures of physical rehabilitation
for 14 days led to reduction of anxiety to physiological levels in all Background and aims.– The association between migration and psy-
mentally healthy patients, reduce the severity of psychosomatic chosis has been described in several countries and backgrounds.
symptoms in the structure of the underlying disease, increased Vulnerability varies according to individual features, migration
satisfaction with the results of treatment by 28.5%. context and host country. To date, several models tried to elucidate
Conclusions.– Analysis of Mental Health study of IDPs and evalu- the etiopathogenesis of psychosis in this population. Our aim was to
ation of comprehensive rehabilitation in terms of the University review the existing models on the etiopathogenesis of non-affective
Clinic show the need for screening mental state when applying for psychotic disorders in migrants.
medical assistance and the desirability of psychological and phys- Methods.– A critical review of relevant studies published in the last
ical rehabilitation of patients during hospital stay somatic profile. 10 years.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The Selective Migration hypothesis posits that increased
interest statement. rates of psychosis among migrants are due to the selective migra-
tion of predisposed individuals. A Socio-Developmental Model
hypothesizes that exposure to adversity interacts with genetic sus-
E-PP0679 ceptibility, disrupting normal neurodevelopment and creating an
Translation and cross-cultural enduring liability to psychosis. Discrimination, as a model of social
validation of the Turkish, Moroccan adversity, was found to induce delusional persecutory ideation.
Arabic and Berber version of the 48 Similarly, the process of Westernization often leads to a break-
down of previously stablished world views, enhancing psychosis
item symptom questionnaire (SQ-48)
risk in genetically predisposed individuals. Adding to this theo-
V. Kovacs* , E. Giltay, I. Carlier, F. Zitman, B. van Hemert
ries, refugees present higher rates of psychosis; they are more
Leiden University Medical Center, Psychiatry, Leiden, The Netherlands
* Corresponding author. likely to experience traumatic situations in their migration path:
pre-migration political conflicts and violence, dangerous migration
Background and aims.– SQ-48 is a valid and clinical useful measure trajectories and forced family separation. In the host country, com-
of general psychopathology. First generation Moroccan and Turk- mon stressors include uncertainty about asylum, unemployment
ish immigrants in the Netherlands have difficulty understanding and social exclusion.
Dutch questionnaires. This study aimed to translate and cross cul- Conclusions.– The increased incidence of non-affective psychotic
tural adapt SQ-48 into Turkish, Moroccan Arabic and Berber and to disorders among migrants has been attributed to a complex
examine their psychometric properties. interaction between genetic factors and distress. With the unprece-
Methods.– Data was used from: (1) psychiatric outpatients with dented levels of global humanitarian crises, elucidation of the
Turkish or Moroccan background (n = 150); (2) reference sample of etiopathogenesis and detection of early signs of psychosis in this
non-psychiatric with Turkish or Moroccan background (n = 103); population might favour improved mental health policies world-
(3) native Dutch psychiatric outpatients (n = 189); (4) reference wide.
sample of native Dutch non-psychiatric (n = 463). Internal con- Disclosure of interest.– The authors have not supplied a conflict of
sistency, AUC’s, means, standard deviations, percentiles, factorial interest statement.
structure, and measurement invariance across ethnic groups were
determined.
Results.– Internal consistency of SQ-48 subscales across ethnic E-PP0681
groups was adequate to high. Seven-factor structure fitted data Involuntary psychiatric treatment of
adequately in total sample and each ethnic group. AUC’s showed first generation immigrants with
acceptable to excellent discrimination between psychiatric outpa- acute mental disorders in Italy. The
tients and non-psychiatric participants in ethnic groups, although
role of forced migration
mean differences between ethnic groups were higher. We estab-
C. Pancheri* , V. Roselli, L. Todini, A. Maraone, V. Fioriti, G.
lished full configural and metric invariance for SQ-48 across ethnic
Mandarelli, S. Ferracuti, M. Biondi, M. Pasquini, L. Tarsitani
groups, but only partial scalar invariance was supported. Two inter-
La Sapienza University of Rome, Neurology and Psychiatry, Rome,
cepts differed (items 8, 28) for combined Moroccan Arabic and
Italy
Berber and Dutch group and five intercepts differed (items 24, 3,
Background and aims.– Migration is a risk factor for the develop-
26, 28, 44) for Turkish and Dutch group.
ment of mental disorders. Immigrants in Europe appear at higher
Conclusions.– We conclude that general psychopathology measured
risk of psychiatric coercive interventions. Reasons include cultural,
by SQ-48 can largely interpreted in the same way for patients from
ethnic and language differences leading to communication prob-
different backgrounds. On some subscales, ethnic groups tended
lems between immigrants and mental health professionals. Aim of
on average to have higher scores than the Dutch group. The Dutch
the study is to explore clinical and migratory factors associated with Background and aims.– Immigrants and refugees are at higher risk
involuntary treatment in a sample of first generation immigrants. for mental health problems having many personal and social factors
Methods.– Socio-demographic, clinical and migratory variables associated with immigration.
were collected and compared with age- gender- and DSM-IV This study’s purpose was to examine the perspective of Franco-
diagnosis-matched sample of native patients. Brief Psychiatric Rat- phone immigrants with respect to their needs, access to services
ing Scale and Clinical Global Impression scale were administered. and use of emotional support.
Results.– 117 immigrated patients were compared to 117 natives. Methods.– Face to face interviews were conducted with 60 new-
Involuntary treatment rates were not significantly different in comers from Winnipeg, Saskatoon and Ottawa, cities with French
immigrants as compared to controls (32% vs 24%). Among immi- minority groups.
grants, asylum seekers were involuntary admitted more frequently Results.– When integrating Canadian society, in a minority linguis-
than economic of family reasons immigrants (50% vs 27%; p = 0.04). tic context, Francophone immigrants face social isolation partly
The length of stay in Italy appears to be a protective factor against related to language. Language barrier has a significant impact on
involuntary treatment: 56% of patients in Italy from less than 2 employability. Challenges facing Francophone immigrants have an
years, 34% of those from 2 to 5 years and 23% from more than 5 impact on their emotional well-being. Family, friends, religious and
year were admitted involuntarily (p = 0.03). cultural communities play a key role in emotional support. Lan-
Conclusions.– Recently immigrated asylum seekers with an acute guage and cultural adaptation were determining factor in assessing
mental disorder appear at risk of involuntary treatment. Since the quality of services received by newcomers. Main recommenda-
coercive interventions can be traumatic and can affect outcomes, tions would be to better inform immigrants of realities of living
strategies to prevent this phenomenon are needed. environments in minority linguistic context, emotional health and
Disclosure of interest.– The authors have not supplied a conflict of well-being, services offered in the official language of their choice
interest statement. and benefits of formal services use. Increase the provision of emo-
tional support services for newcomers and tailor services to specific
needs of subpopulations, including men, the elderly, students and
E-PP0682 those with young children. Finally, the lack of cultural sensitivity is
Moderating effect of forgiveness on felt in the health system organization, with limited access to ser-
the trauma-PTSD relationship in vices in the official minority language and to professionals from
various ethno-cultural backgrounds.
African refugees
Conclusions.– Better integrate support services, both in health
S. Regev1* , V. Slonim-Nevo2
1 institutions and community services, religious authorities, and
University College London, School of Public Policy, London, United
community leaders by creating partnerships between stakeholders
Kingdom; 2 Ben-Gurion University, Spitzer Department of Social
working within these services.
Work, Beer Sheva, Israel
interest statement.
Background and aims.– Forgiveness has been shown to be associated
with improved mental health among survivors of violence. How-
ever, little is known about the relationship between forgiveness and E-PP0684
psychological stress among individuals exposed to multiple war- Migrant patients and first episode
related traumatic events. This study examined the relationship of psychosis: an observational study in
cumulative war trauma to severity of posttraumatic stress disorder an acute patient unit
(PTSD) symptoms, and the role of forgiveness in moderating that S. Vilas Boas Garcia* , R. Mateiro, I. Pinto, T. Teodoro, M. Martins,
relationship. M.J. Avelino, J. Salgado
Methods.– Forty-nine African asylum-seekers residing in Israel Centro Hospitalar Psiquiátrico de Lisboa, Clínica 1, Lisbon, Portugal
self-reported on direct traumatic exposure, PTSD symptoms and * Corresponding author.
forgiveness.
Results.– Results indicated that increased exposure to war traumas Background and aims.– The mental health of migrant population is
significantly predicted increased PTSD scores. Significant moderat- an increasing study field.
ing effect indicated that the cumulative effect of trauma on PTSD The aim of this study is to compare sociodemographic and clinical
severity was strong and significant among asylum-seekers who variables between migrant and native patients.
were low in forgiveness, but insignificant among those who were Methods.– A total of 101 First Episode Psychosis patients were
high in forgiveness. included. The 10th revision of the International Statistical Classifi-
Conclusions.– Low levels of forgiveness may contribute to increase cation of Diseases and Related Health Problems (ICD-10) was used
the risk of negative mental health outcomes in traumatized for diagnosis. Data relating sociodemographic and clinical charac-
refugees. These findings offer preliminary insights into the poten- teristics were collected retrospectively from case notes.
tial role of forgiveness in promoting effective coping strategies. Our Results.– The migrant group represented 33% (N = 33) of the patients
study supports further investigations into the relevance of forgive- admitted. The average age was 36 for the migrant group and 34 for
ness in refugee mental health in order to enhance current clinical the native group. The percentage of male patients was higher in
assessments and interventions. both groups: 52% (N = 17) in the migrant and 54% (N = 37) in the
Disclosure of interest.– The authors have not supplied a conflict of native group. In both groups, the majority of patients were single
interest statement. and unemployed.
The most frequent diagnosis was F29 – Psychosis NOS (not oth-
erwise specified), according to the ICD-10, which constituted the
E-PP0683 diagnosis of discharge of 52% (N = 17) of patients in the migrant
Mental health needs of french group and 31% (N = 21) of patients in the native group. Compulsory
immigrants in Canada admission was 48% (N = 16) in the migrant group and 50% (N = 34)
R. Tempier in the native group. The duration of untreated psychosis was 59
Montfort hospital, psychiatry, ottawa, Canada weeks for the migrant group and 36 weeks for the native group.
* Corresponding author. Conclusions.– Sociodemographic variables were similar in migrant
and native groups. No relevant differences were found in the
proportion of involuntary treatment between migrant and native
patients. Migrant patients had a higher duration of untreated psy- Background and aims.– The Auditory hallucination (AH) is a core fea-
chosis. ture of schizophrenia spectrum disorders, having a disruptive effect
Disclosure of interest.– The authors have not supplied a conflict of on patient functionality. Furthermore, AH is associated with higher
interest statement. rates of depression and suicide. It is crucial to fully understand how
the symptom develops in order to promote target therapies, with
higher efficiency and fewer secondary effects. Although the aetiol-
ogy of the symptom is still unknown, the advance of functional MRi
E-Poster Presentation: brought new and relevant data about the origins of AH. Based on
Neuroimaging/Neuroscience in Psychiatry - Part I the advance of functional MRi research, we aim to collect the new
data and expose the advances in the AH knowledge.
Methods.– The present study is based on an extensive review of
E-PP0685 literature through Pubmed research motor, using the words “func-
tional MRI” and “hallucinations”.
The interactions of 5-HT pathway
Results.– The majority of the works appoint auditory cortex and
genes and pretreatment regional speech processing regions as critical substrates for AVH generation,
cerebral blood flow modulate early although many other areas seem to be active while AH is occurring.
antidepressants response in major Authors do believe that exists impaired connectivity between dif-
depressive disorder ferent brain regions which is responsible for abnormal functional
Z. Hou1,2* , Y. Yin1 , Y. Zhang1 , Y. Yuan1 integration within neural networks.
1 Institute of Psychosomatic Medicine, Affiliated Zhongda Hospital, Conclusions.– Although it’s clear the great importance of the audi-
School of Medicine, Southeast University, Department of tory cortex and speech processing regions in the AVH generation,
Psychosomatics & Psychiatry, Nanjing, China; 2 Columbia University we still don’t fully understand the specific type of aberrant connec-
College of Physicians and Surgeons- The New York State Psychiatric tion between these two areas and the role of the other brain areas
Institute, Department of Psychiatry, New York, USA activated during AVH.
interest statement.
Background and aims.– The impact of multilocus genes of 5-HT
pathway on brain function during the antidepressant medication
remains unclear. We aimed to examine the potential interacted E-PP0687
effect between pathway genes and treatment response on pretreat- Imaging findings in patients with
ment regional CBF, and further explore whether the distinct CBF clozapine-associated obsessive
features can effectively predict early antidepressant response.
Methods.– Twenty-two responsive depression (RD) and twenty-
compulsive symptoms
Ş. Bıçakcı1* , K. Karli Oguz2 , A.C. Has3 , E. Bulut2 , S. Karahan4 , A.
two non-responding depression (NRD) received serotonin (5-HT)
Ertugrul5
pathway gene sequencing and paused arterial spin labeling and T1 1 Van Research and Training Hospital, Psychiatry, Van, Turkey; 2
images scan. The interactions were determined by efficacy × SNPs
Hacettepe University Faculty of Medicine, Department of Radiology,
analysis of covariance. The regional cerebral blood flow (CBF)
Ankara, Turkey; 3 Bilkent University, National Magnetic Resonance
interacted with SNPs in 5-HT pathway genes and early treatment
Research Center UMRAM, Ankara, Turkey; 4 Hacettepe University
response were selected for further correlation and receiver operat-
Faculty of Medicine, Department of Biostatistics, Ankara, Turkey; 5
ing characteristic (ROC) analyses.
Hacettepe University Faculty of Medicine, Department of Psychiatry,
Results.– Twelve SNPs of eleven genes showed significant inter-
Ankara, Turkey
actions with early antidepressant response on regional CBF. * Corresponding author.
Significant correlations were revealed between the regional CBF in
left cerebellum Posterior Lobe, right medial frontal gyrus (MeFG R), Background and aims.– This study aimed to compare the cognitive
left middle temporal gyrus (MTG L) and short-term or mid-term functions and cerebral structural changes in patients who exhib-
antidepressant response. When combined three metrics of CBF in ited and not exhibited obsessive compulsive symptoms (OCS) after
MeFG R (interacted with the SNP of HTR3D rs12493550), the CePL R clozapine treatment with healthy controls.
(HTR1A rs878567) and the Precuneus L (TPH2 rs11178998) for ROC Methods.– Nine patients who developed OCS after clozapine
analysis, an optimized discrimination power was revealed in clas- (Clz + OCS), 9 patients who didn’t exhibit OCS after clozapine
sifying the NRD from the RD. (Clz − OCS) and 9 age, sex, education matched controls were
Conclusions.– The interaction between multilocus SNPs and early studied. Patients were assessed using Positive and Negative Syn-
efficacy can be revealed on the dimension of CBF, and the short- drome Scale (PANSS), Yale-Brown Obsession and Compulsion Scale
term and middle-term efficacy may be mediated by different loci (YBOCS), neurocognitive test battery and Diffusor Tensor Imaging
in 5-HT pathway and brain regions. The features of 5-HT pathway (DTI). The control group was assessed using neurocognitive test
and CBF may provide a novel indicator for modifying treatment in battery and DTI. Analysis of the imaging data was performed using
the early stage. region of interest method; corpus callosum, left and right ALIC, cin-
Disclosure of interest.– The authors have not supplied a conflict of gulum and thalamus were examined, and fractional anisotropy (FA)
interest statement. values were measured.
Results.– The total number of hospitalizations, PANSS positive and
general psychopathology sub-scores were significantly higher in
E-PP0686 the Clz + OCS group compared to Clz − OCS. The three groups had
The phenomena of auditory verbal no significant difference with respect to the FA values of the exam-
hallucinations and the role of ined brain regions. In the Clz + OCS group, total YBOCS scores were
functional MRI: a systematic review correlated positively with corpus callosum and negatively with left
J. Pereira* , V. Viveiros cingulum FA values. The Clz + OCS group significantly outperformed
Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisbon, Portugal Clz − OCS in Controlled Oral Word Association Tests and Digit Span
* Corresponding author. Forward tests.
Conclusions.– Better cognitive functions such as attention in this
group may be considered as the cause or the result of the accompa-
nying obsessive compulsive symptoms. The relationship between nificantly correlated with the reduction rate of 17-item Hamilton
the severity of OCS and FA values of certain brain regions empha- Rating Scale for Depression.
sizes the importance of microstructural changes in these regions. Conclusions.– The feeder connection indicates the information
Disclosure of interest.– The authors have not supplied a conflict of transmission between the core and non-core architecture of brain
interest statement. networks. Pathological lesion on MDD was associated with abnor-
mal core organization, while patient remission was association
with compensation from non-core organization. These results sug-
E-PP0688 gest that the dysfunction arisen from the core brain regions is
Recovery compensation upon compensated through information interactions between core brain
hierarchical subnetworks in major regions and functionally diverse regions.
depressive disorder: a longitudinal
interest statement.
study across multi-sites
X. Wang1* , J. Qing2 , Q. Lu1 , Z. Yao3
1 Southeast University, Key Laboratory of Child Development and E-PP0689
Learning Science-School of Biological Sciences & Medical Engineering, Neuroticism and resilience - a MRI
Nanjing, China; 2 Nanjing University of Science and Technology, The
Key Laboratory of Intelligent Perception and Systems for
study on the neuroanatomcial
High-Dimensional Information of Ministry of Education, School of correlates
Computer Science and Engineering-, Nanjing, China; 3 Nanjing C.C. Schultz1,2
1 Klinikum Fulda gAG, Universitätsmedizin Marburg - Campus Fulda,
Medical University, Department of Psychiatry, Affiliated Nanjing
Brain Hospital, Nanjing, China Pacelliallee 4- 36043- Fulda- Deutschland., Klinik für Psychiatrie und
* Corresponding author. Psychotherapie, Fulda, Germany; 2 Jena University Hospital,
Department of Psychiatry, Jena, Germany
Background and aims.– Brain connectomes comprise of a minority
of efficiently interconnected rich club nodes that are considered as Background and aims.– Neuroticism and resilience are two poles
‘high order regions’. Based on this concept, we propose a hierarchi- of the humans’ constitution mediating risk for psychiatric illness.
cal brain structure consisting of five subnetworks (e.g., rich, feeder, However, little is known about the brain morphological underpin-
rich-feeder and feeder-local subnetwork), and evaluate these hier- nings of these variables. Thus, we performed a MRI study exploring
archical subnetworks’ longitudinal change of major depressive potential correlations of psychometric neuroticism and resilience
disorder (MDD) patients after antidepressant treatment. in a large cohort of healthy subjects.
Methods.– Fifty-five MDD patients performed diffusion tensors Methods.– We investigated potential relationships between cortical
imaging scan before and after 8-weeks antidepressant treatment. thickness and cortical folding and the magnitude of neuroticism
Each individual brain network was divided into five hierarchical (NEO-FFI) and resilience (Wagnild and Young 1993). FreeSurfer was
subnetworks. The critical subnetwork and its discriminative nodes used to analyze the obtained high resolution 3 T MRI scans in more
to differ the pre-/post-treatment patients were explored via than 100 participants.
support vector machine analysis with graph kernel (figure 1). Results.– We demonstrate significant correlations between neuroti-
cism and cortical folding in the left DLPFC (Schultz et al., 2017) and
with resilience and cortical thickness in a right hemispherical clus-
ter incorporating the lateral occipital cortex, the fusiform gyrus, the
inferior parietal cortex as well as the middle and inferior temporal
cortex.
Conclusions.– Functionally relevant cortical regions were found to
be associated with the magnitude of psychometric neuroticism and
resilience. Our findings indicate that structural variations of the
DLPFC might be involved in the modulation of neuroticism, more-
over cortical thickness variations in cortical regions engaged in the
processing of stress and trauma might be relevant for modulating
resilience regarding psychiatric illness.
interest statement.
E-PP0690
Structural neuroimaging in
depression: results from voxel based
morphometry study
D. Stoyanov1* , S. Kandilarova1 , N. Sirakov2 , K. Specht3
1 Medical University, Psychiatry and Medical Psychology- Research
Figure 1. Critical subnetwork and its discriminative nodes to dif-
fer the pre-/post-treatment patients via support vector machine Complex for Translational Neuroscience, Plovdiv, Bulgaria; 2 Medical
analysis with graph kernel. University, Imaging Diagnostics, Research Complex for Translational
Neuroscience, Plovdiv, Bulgaria; 3 University of Bergen, Biological
Results.– The feeder-local subnetwork presented the most discrim- and Medical Psychology, Bergen, Norway
inative power in differing pre-/post- treatment patients, while * Corresponding author.
the rich-feeder subnetwork had the most discriminative power

when comparing pre-treatment patients and controls. Further- Background and aims.– Voxel Based Morphometry (VBM) is a new
more, based on the feeder connection, which is linked to valuable promising technique that compare different patients’ brains on a
regions to other regions, degree change rates were found to be sig- voxel-by-voxel basis after deformation fields have been used to
spatially normalize the images. The method is used to detect dif-
ferences in the density of the brain tissue, and present the results E-PP0692
quantitatively. White matter microstructure and
The aim of our study is to present our experience in the field of VBM
cortical thickness in individuals at
of grey matter reduction in patients with depressive disorders.
Methods.– For the present study we recruited fifty adult subjects familial risk for affective disorders
complying with the DSM-IV-TR criteria for depressive episode of and schizophrenia
major depressive disorder/bipolar disorder and forty-two age and I. Lebedeva1* , A. Tomyshev1 , P. Kananovitch2 , U. Popovitch2 , A.
sex matched healthy controls. Pomytkin1 , V. Kaleda2
1 Mental Health Research Center, Lab. of Neuroimaging and
High resolution structural scans were obtained from all participants
on a 3T MRI system. MRI data were analysed using the SPM 12 Multimodal Analaysis, Moscow, Russia; 2 Mental Health Research
software running on MATLAB R2017 for Windows and the CAT 12 Center, Dep. Endogenous Mental Disorders and Affective States,
toolbox implemented in SPM. Moscow, Russia
Results.– We performed two sample t-test on the grey matter
images with a total intracranial volume as co-variable. The level
Background and aims.– The analysis of neuroanatomical profile in
of significance was set to p > 0.05 false discovery rate corrected and
the familial risk group is a highly informative approach to the study
an extent threshold of 36 voxels per cluster. The contrast between
of endophenotype of the disease.
controls and patients yielded significant differences in clusters
Objectives.– The aim was to determine the brain structural charac-
encompassing left medial frontal (MFC) and anterior cingulate cor-
teristics in unaffected first degree relatives (FDR) of patients with
tex (ACC) as well as right frontal and temporal regions. The reverse
affective disorders and schizophrenia.
contrast exploration did not produce any surviving significant clus-
Methods.– 13 young mentally healthy FDR of patients with affective
ters.
disorders (F31–33) and 13 – of patients with schizophrenia (F20)
Conclusions.– There has been confirmed significant reduction of
as well as two corresponding age and sex matched control groups
grey matter volume in specific regions in patients with depressive
(without family history of mental disorders) underwent structural
disorder when compared to healthy controls.
MRI and diffusion weighted MRI at 3T Philips scanner. Surface-
based morphometry and tractography methods using FreeSurfer
interest statement.
5.3.0 and TRACULA algorithms were applied to investigate cerebral
cortex anatomy and white matter microstructure.
E-PP0691 Results.– Neuroanatomical alterations have been found only in the
relatives of patients with schizophrenia. The group was charac-
Occipital bending and mental illness terized by increased radial diffusion (anterior thalamic radiation
R. Saraiva* , A.C. Sereijo, M.J. Gonçalves, R. Coentre, L. Castanheira
and uncinate fascicles of both hemispheres; right superior lon-
Hospital Santa Maria Centro Hospitalar Lisboa Norte, Psiquiatria,
gitudinal fascicle), decreased fractional anisotropy (right anterior
Lisboa, Portugal
* Corresponding author. thalamic radiation, uncinate fascicles of both hemispheres, tem-
poral part of right superior longitudinal fascicle) and increased
Background and aims.– Global hemispheric asymmetry and abnor- grey matter thickness in a medial part of the left superior frontal
malities in brain lateralization have been suspected to be present in gyrus.
psychiatric disorders. The phenomenon of occipital lobe torquing Conclusions.– The findings suggest that the familial high risk of
has been named occipital bending. There have been studies access- schizophrenia might be associated with an altered trajectory of
ing the existence of an association between occipital bending and brain development. However whether it is pathological or compen-
mental illnesses. The purpose of this review is to investigate which satory processes remains to be elucidated via further longitudinal
mental disorders are associated with occipital bending. research.
Methods.– Medline was screened through September 2018. Studies The work was supported by RFBR grant 17-06-00985
accessing occipital bending or the “occipital component” of human Disclosure of interest.– The authors have not supplied a conflict of
brain torque or Yakovlevian torque in any mental disorder were interest statement.
eligible. In addition reference lists of identified original articles or
reviews were searched manually. Studies that were not written in
E-PP0693
english or portuguese were excluded.
Results.– Five studies including 317 patients (166 controls, 51 Functional neuroimaging of
patients with depression, 65 with schizophrenia and 35 with hypochondriacal attitude: a pilot
bipolar depression) were included. Occipital bending was more study
prevalent in patients with any of these psychiatric disorders when O. Dobrushina1 , G. Arina2 , E. Kremneva3 , A. Suslina3 , M.
compared with controls. Gubanova1 , A. Belopasova1 , M. Iosifyan2* , L. Dobrynina1 , M.
Conclusions.– This literature review found evidence in favor of Krotenkova3
an association between occipital bending and psychiatric illness. 1 Research Center of Neurology, Third neurological department,
These structural changes seem to be present in affective and psy- Moscow, Russia; 2 Moscow State University, Department of
chotic disorders and also, in a much lesser extent, in healthy Psychology, Moscow, Russia; 3 Research Center of Neurology,
subjects. More studies should be made to better understand what’s Neuroradiology Department, Moscow, Russia
the exact relation between occipital bending and psychiatric disor- * Corresponding author.
ders and how much it contributes to the disease process.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– Hypochondria is a key mechanism in
interest statement. somatoform disorders. The neural mechanisms underlying this
important phenomenon are unknown. The study aims to develop
a functional neuroimaging technique allowing investigation of the
brain mechanisms underlying hypochondriacal attitude.
Methods.– We developed an original modification of a classical
heartbeat detection task (interoceptive condition — listening to
heartbeat, vs. control exteroceptive condition — listening to audial
tones) implemented in the fMRI setting. During the interoceptive
condition, a false feedback was presented on the screen: green or E-PP0695

red indicator. The participants were told that green indicates rest- Searching for origins of sex
ing heartbeat and red indicates fast heartbeat (see figure). In fact,
differences that underlie mental
the color was changing in random order. Six volunteers entered the
pilot study.
health disorders: are sex differences
Results.– During the “green” heartbeat detection condition (positive in brain connectivity evident in
false feedback), a classical pattern of interoceptive activation was humans before birth?
observed, involving anterior insula and supplementary motor area. C. Espinoza-Heredia1* , J.L. Hect2 , M.D. Wheelock3,4 , A.T.
Negative false feedback (red indicator) resulted in activation of Eggebrecht4 , M.E. Thomason1,5
orbitofrontal cortex and amygdala (“the fear network”). Thus, false 1 New York University Medical Center, Department of Child and
beliefs about incorrect functioning of the body resulted in activa- Adolescent Psychiatry, New York, USA; 2 Wayne State University,
tion of fear-related areas and inhibition of interoceptive processing. Merrill Palmer Skillman Institute for Child and Family Development,
This effect may have similarities with the brain-level mechanisms Detroit, MI, USA; 3 Washington University School of Medicine,
of hypochondria. Department of Psychiatry, St. Louis, MO, USA; 4 Washington
Conclusions.– The pilot study demonstrates feasibility of functional University School of Medicine, Mallinckrodt Institute of Radiology, St.
neuroimaging in investigation of hypochondria. Louis, MO, USA; 5 New York University Medical Center, Department
Disclosure of interest.– The authors have not supplied a conflict of of Population Health, New York, USA
Background and aims.– Prevalence of psychiatric disorders differs in

E-PP0694 males and females, and neurological studies suggest that sex-linked
Are there changes in functional variation in the brain may underlie this dissociation. However,
the origin of this difference, and how early in human life sexual
connectome after one year from the dimorphism in brain function emerges is a topic that requires fur-
onset of psychosis? Longitudinal ther investigation. Here, we address this gap by assessing brain
resting state functional MRI resting-state functional connectivity (RSFC) between and within
connectivity study brain networks as it relates to fetal sex and gestational age (GA).
B. Dvoracek* , Y. Zaytseva, F. Spaniel Methods.– We examined 118 typical human fetuses (70 male; 48
National Institute of Mental Health- Klecany, 3rd Faculty of Medicine, female) between 25.9 and 39.6 weeks GA. Infomap was used to
Department of Psychiatry, Klecany, Czech Republic derive 16 separable fetal neural networks distributed across corti-
* Corresponding author. cal, subcortical, and cerebellar regions. Using enrichment analysis,
we identified network pairs revealing distinct patterns of GA-
Background and aims.– The latest research in schizophrenia mainly related change in males and females.
focuses on the period during the first occurence of psychotic symp- Results.– Sex-dependent variation of between- and within- net-
toms, when the progressive reduction of gray matter was observed. work RSFC-GA associations was observed: while females exhibited
Structural changes could be mirrored in resting state functional GA-related variation in connectivity between posterior cingulate
connectivity of the brain. The aim of our study was: firstly, to com- and temporal pole regions, and between pre-frontal and cerebellar
pare functional connectome (rsFC) in patients with first episode of regions, males demonstrated increased intracerebellar RSFC with
psychosis (FEP) and healthy controls (HC); secondly, to explore rsFC advancing age.
in both groups longitudinally. Conclusions.– Such observations confirm that sex-related differ-
Methods.– We obtained resting state functional and structural scans ences in functional brain development are present before birth. An
of FEP N = 25 (M = 12; Age 28, 24+/−7,7) and HCN = 26 (M = 14; Age important next step in this line of research will be to follow children
29, 23+/−5,70). We have explored the rsFC of both groups at the across early development and discover how sex-related variation
baseline and after one year. For analysis we chose 32 seeds repre- in network development relates to future health outcomes.
senting functional networks. Threshold set at p > 0,05 FDRcorr. Disclosure of interest.– The authors have not supplied a conflict of
Results.– We found no differences comparing patients and con- interest statement.
trols neither at the baseline, nor after one year follow-up. The
comparison in FEP at the baseline and one year after revealed
a hyperconnectivity between Default Mode Network (DMN) and E-PP0696
Salience Network (SN) (p = 0.0228), a hyperconnectivity between Altered frontal function during
SN and Dorsal Attention Network (p = 0.0287) and a hypoconnectiv-
sensory gating in panic disorder: an
ity between DMN and Frontal Parietal Network (p = 0.0466). During
follow up in HC we observed a hyperconnectivity between SN and MEG study
Cerebellar Anterior Network (p = 0.0203) and between anterior and C.H. Cheng1* , S.C. Hsu2 , C.Y. Liu2
1 Chang Gung University, Department of Occupational Therapy,
posterior parts of the SN (p = 0.0409).
Conclusions.– Our study did not show any differences neither at the Taoyuan, Taiwan R.O.C.; 2 Chang Gung Memorial Hospital,
baseline, nor after one year follow-up in rsFC between HC and FEP. Department of Psychiatry, Linkou, Taiwan R.O.C.
Our longitudinal analysis showed differences in both groups. The
differences were found mainly in networks responsible for cogni- Background and aims.– There is increasing evidence that patients
tive control and saliency. with panic disorder (PD) exhibit abnormality in early-stages infor-
Disclosure of interest.– The authors have not supplied a conflict of mation processing, even for the non-threatening stimuli. A previous
interest statement. EEG study revealed that PD patients had a deficit in sensory gating
(SG), a protective mechanism of the brain to filter out irrelevant
sensory inputs. However, the neural correlates of SG deficits in
PD are poorly understood. Thus, we aimed to elucidate the neural
generators of SG deficits in PD, and to examine whether SG abnor-
mality, if any, would be associated with clinical manifestations.
Methods.– This study recruited 18 PD patients and 20 age-, gender-

matched healthy controls to perform auditory paired-stimulus
paradigm by using magnetoencephalographic (MEG) recordings.
Results.– Compared to control group, PD patients demonstrated
significantly higher M50 SG ratios in the right inferior frontal
gyrus (RIFG) (p = 0.002), and higher M100 SG ratios in both RIFG
(p = 0.018) and right superior temporal gyrus (RSTG) (p = 0.027). It
was important to note that in the RIFG, M50 SG ratios were cor-
related with Body Sensation Questionnaire (BSQ) (p = 0.003), and
with Distractibility category of Sensory Gating Inventory (p = 0.038)
among the studying PD patients.
Conclusions.– Our data suggested that PD patients showed defi-
cient ability to filter out repetitive, irrelevant information, and such
defect in early-stage information processing might lead to a detri-
mental effect on behavioral and cognitive performance. Figure 1. Free-water in gray matter as baseline and follow-up by
Disclosure of interest.– The authors have not supplied a conflict of group.
interest statement.
Conclusions.– Extracellular free-water in the brain is a reliable find-
ing in FEP, and in SSD appears to decrease over the early course of
E-PP0697 the illness. Could it be antipsychotics?
Transient and diagnostic specific Acknowledgements.– Fundación Alicia Koplowitz, AES-ISCIII, CIBER-
elevated free-water in the brain of SAM
first-episode subjects interest statement.
D. Berge1* , A. Mané1 , T. Lesh2 , C.S. Carter2 , V. Perez1 , A. Bulbena3 ,
B. Cabrera4 , J. Janssen5 , M. Bernardo4 , M. Parellada6
1 Hospital del Mar Medical Research Institute IMIM, Neuroscience,
E-PP0698
Psychiatry, Barcelona, Spain; 2 University of California, Department
How a disease burden affects the
of Psychiatry and Behavioral Sciences, Davis, Sacramento, USA; 3
Autonomous University of Barcelona, Psychiatry, Barcelona, Spain; 4 organization of neural networks in
Hospital Clínic de Barcelona, Barcelona Clínic Schizophrenia Unit, schizophrenia?
Barcelona, Spain; 5 Centro de Investigación Biomédica en Red de P. Krukow1* , K. Jonak2,3 , H. Karakuła-Juchnowicz3
1 Medical University of Lublin, Department of Clinical
Salud Mental, Cibsersam, Madrid, Spain; 6 Hospital General
Universitario Gregorio Marañón, IiSGM, Child and Adolescent Neuropsychiatry, Lublin, Poland; 2 Lublin University of Technology,
Psychiatry Department, Madrid, Spain Department of Biomedical Engineering, Lublin, Poland; 3 Medical
* Corresponding author. University of Lublin, Chair of Psychiatry, I Clinic of Psychiatry,
Psychotherapy and Early Intervention, Lublin, Poland
Background and aims.– Recent diffusion imaging studies have * Corresponding author.
shown higher free-water (FW) in gray matter (GM) and white mat-
ter (WM) in psychosis (Pasternak 2012). Although FW has been Background and aims.– The hypothetical impact of factors asso-
related to immune pathological processes, little is known about ciated with mental disease burden (e.g. duration of the illness,
the stability and significance of these findings. prolonged pharmacological treatment, consolidating and deepen-
Methods.– To determine tissue-specific FW abnormalities in first- ing of the psychopathological symptoms) on the organization of
episode psychosis (FEP), as part of the multi-center PEPs study, neural networks in schizophrenia (SZ) patients has not beign fully
132 FEP and 108 HC were scanned and clinically assessed. Among elucidated so far. Therefore, the aim of this study was to com-
them, 45 FEP and 41 HC were longitudinally assessed and rescanned pare the structures of the neural networks between two groups of
after two years. FEPs were classified as schizophrenia spectrum SZ patients significantly different in mentioned aspects of disease
disorder (SSD) or non-SSD. Using scalar tissue-specific averages, burden.
voxel-wise analysis in skeletonised WM and vertex-wise analysis Methods.– Two group of SZ patients participated in the study: a
in GM surface, FA and FW were cross-sectionally and longitudinally first-episode subjects and a group of patients with illness duration
compared between groups. longer than 5 years and at least three psychotic relapses requir-
Results.– SSD and non-SSD subjects showed higher baseline FW in ing psychiatric hospitalizations. All participants were assessed with
temporal and frontal regions of the GM surface and in whole GM resting-state EEG to estimate functional connectivity with the
average (p.adj (SSD vs. HC) = 0.003, p.adj (Non-SSD vs. HC) = 0.040). phase lag index algorithm and the minimum spanning tree (MST)
SSD, but not non-SSD, showed a) higher FW in several WM tracts for the characterization of network topology.
and in whole WM (p.adj (SSD vs. HC) = 0.049) and b) a significant Results.– The comparison of networks architecture in the studied
FW decrease over time in right temporal regions of GM surface and groups revealed significant between-group differences in between-
in whole GM average (p.adj = 0.011). See Figure 1. ness centrality and tree hierarchy in the beta-band and hierarchy
in the gamma-band. MST results indicated that in the beta band
the network of patients more burdened with the psychotic disease
was characterized by more centralized network, compared with
first-episode sample which showed more decentralized topology.
Groups differed also in the topological displacement of hubs over
the cortical surface.
Conclusions.– Obtained results suggest that prolonged mental ill-
ness affect the organization and topological features of the neural
networks leading to more severe pathologies in efficient informa-
tion processing within the networks.
interest statement.
E-PP0699 atrophy on brain MRI, (3) test for correlations between cognitive
A pilot case-control study functions and volumetric parameters of thalamus.
investigating the role of the locus Methods.– 60 patients (46 F, 14 M) with RRMS at an early clini-
cal stage (median EDSS - Expanded Disability Status Scale score
coeruleus in Alzheimer’s disease of 1,75) underwent neuropsychological assessment using comput-
R. Hou
erized cognitive screening battery (Central Nervous System Vital
University of Southampton, Department of Psychiatry, Faculty of
Signs) and MoCa (Montreal Cognitive Assessment). Brain structures
Medicine, Southampton, United Kingdom
volumetry was done using automatic segmentation technique (vol-
Brain) with 1,5T MR system acquisition. The length of the disease
Background and aims.– The locus coeruleus (LC) is a tiny nucleus and the number of relapses were noted.
in the brain stem which is the major source of noradrenaline Results.– Psychomotor speed, reaction time and information pro-
(NA). Recent research has found extensive LC degeneration and NA cessing speed were the most impaired cognitive functions in
depletion, which are among the earliest pathologies in Alzheimer’s RRMS patients. For the three cognitive domains: psychomotor
Disease (AD). However, the contribution of the LC and NA to cogni- speed, complex attention and simple attention, thalamic area was
tive decline in disease progression in AD has been underappreciated the most sensitive MRI marker. Decreases of total thalamus vol-
and under-investigated due to methodological difficulties of direct ume were associated with overall neurocognitive status of RRMS
measures of LC activity. Most evidence comes from animal and patients.
post-mortem studies. Our research group have developed an Conclusions.– These findings suggest that thalamic atrophy is a clin-
imaging protocol to directly measure LC signal changes using a ically meaningful biomarker of cognitive decline in patients with
high-resolution magnetic resonance imaging (MRI) imaging tech- early stage of RRMS.
nique. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– An optimised neuromelanin-sensitive MRI imaging pro- interest statement.
tocol using high-resolution fast spin-echo T1-weighted sequence
was developed in detecting LC signal intensities in AD patients and
matched healthy controls. Data was acquired on a Siemens 3T Skyra E-PP0701
MRI scanner, using a 20-channel head coil. A novel pre-processing TC-99M HMPAO brain perfusion
system using ImageJ was developed and applied to the analysis of imaging in cases of resistant
raw imaging data. depression
Results.– There were significant difference between average refer- G. Dzhupanov1* , D. Vasileva2
ence ROI and LC ROI signal intensities (p < 0.05, Wilcoxon Signed 1 Medical University Sofia- Georgi Sofiiski Str.1, Department of
Rank Test) and the LC region was significantly brighter than Psychiatry and Medical Psychology. University Multiprofile Hospital
the reference region. Preliminary analysis of indicated a lower for Active Treatment in Neurology and Psychiatry “St. Naum”, Luben
LC contrast ratio in the AD group comparing to the control Russev Str.1, Sofia, Bulgaria; 2 Medical University Sofia, Georgi Sofiiski
group. Str.1, Clinical Centre of nuclear Medicine, Radiotherapy, Medical
Conclusions.– Findings from this study indicate lower LC signal Oncology, University Multiprofile Hospital for Active Treatment “St.
intensity in AD patients comparing to healthy controls. Future Ivan Rilski”, Academic Ivan Geshov Str.15, Sofia, Bulgaria
investigation of the role of the LC in the pathogenesis of AD may * Corresponding author.
lead to the development of new treatment targets.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.–
interest statement. Introduction.– Functional brain imaging including SPECT/CT
receives more and more attention in the field of psychiatry (1,2).
Sometimes it is used for differential diagnosis meanly between
E-PP0700 functional disorders like major depression and psychorganic dis-
Thalamic atrophy as a predictor of orders like dementias. There is also accumulating data supporting
cognitive impairment in early stage of meaning of functional imaging techniques in subtyping different
forms of neuropsychiatric diseases (3).
relapsing – remitting multiple
Objectives.– To record and accumulate data for the brain perfu-
sclerosis (RRMS) sion in patients with resistant therapeutically resistant depressive
Ż. Brudkowska1* , E. Kurys - Denis2 , U. Skrobas3 , R. Maciejewski4 , episode.
H. Karakuła - Juchnowicz5 Methods.– Visual analysis of SPECT/CT - Tc-99m HMPAO imaging
1 Medical University of Lublin, Department of Clinical
results of a series of patients. Participants have signed an informed
Neuropsychiatry, Lublin, Poland; 2 Medical University of Lublin, consent.
Department of Clinical Radiology, Lublin, Poland; 3 Medical Results.– There is predilection for hypoperfusion in most cases
University of Lublin, Department of Neurology- Department of in frontal and temporal areas as it was manifested on SPECT/CT
Human Anatomy, Lublin, Poland; 4 Medical University of Lublin, images. Usually, but not exclusively this hypoperfusion was more
Department of Human Anatomy, Lublin, Poland; 5 Medical University pronounced in left hemisphere. Exact location in the lobes varies.
of Lublin, Department of Clinical Neuropsychiatry- I Department of From the abnormalities in other areas aberrations in basal ganglia
Psychiatry, Psychotherapy and Early Intervention, Lublin, Poland were most pronounced. A case of hyperperfusion in temporal lobe
in a hallucinating patient was identified.
Background and aims.– Previous imaging and neuropathological Conclusions.– The results are in accordance with some previ-
studies have demonstrated thalamic involvement in multiple scle- ous SPECT data concerning depressive disorders revealing frontal
rosis. Cognitive deficits worsen the quality of life in multiple and temporal abnormalities. These are preliminary data from for
sclerosis and may be predicted by deep gray matter atrophy, espe- now relatively small group of patients with depression and neu-
cially in the thalamic region. This relationship has not been widely ropsychiatric diseases as a whole. Our further aim is to follow
studied in the early stage of the disease. up dynamics and to use provocation techniques for a deeper
The aims of this study were to: (1) assess cognitive deficits in understanding of brain mechanisms of disease and to compare
patients with early stage relapsing-remitting multiple sclerosis different subgroups of depressive and other neuropsychiatric
(RRMS) using neuropsychological tests, (2) search for thalamic patients.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– 35 patients with schizophrenia diagnosis (males = 19;
interest statement. 29.5 years; SD 8.4 years) and 20 controls (males = 11, 29.6years, SD
9.5 years) participated in the study. 24 patients received antipsy-
chotic monotherapy, 12 polytherapy, 11 clozapine.
E-PP0702 The typical oddball (with pure-sinusoidal tones and single deviant
Endophenotype of psychiatric illness to duration increment) and multi-feature (each stimuli consists of
and cortical hyperexcitability in a eight harmonics) with eight different deviants developed by Pakari-
nen et al. (2010)) paradigms were applied.
healthy human cohort
Results.– MMNs elicited with oddball and deviants from multi-
J.P. Horstmann1* , M. Muthuraman2 , V.C. Chirumamilla2 , S.
feature paradigm: frequency, location, density and added noise
Groppa2 , K. Lieb1 , H. Grabe3 , M. Lotze4 , J. Vogt5 , R. Nitsch5 , O.
were significantly reduced in schizophrenia group. Effects of
Tüscher1
1 University Medicine Mainz, Psychiatry and Psychotherapy, Mainz, clozapine, polytherapy and interaction between clozapine and
polytherapy were observed for multi-feature paradigm deviants
Germany; 2 University Medicine Mainz, Neurology, Mainz, Germany;
3 University Medicine Greifswald, Psychiatry and Psychotherapy, (duration: clozapine vs non-clozapine: F(1,31) = 9.3; p = 0.005;
brightness: mono- vs polytherapy: F(1,31) = 5.8, p = 0.022; density:
Greifswald, Germany; 4 University Medicine Greifswald,
clozapine vs monotherapy group: F(1,31) = 6.1; p = 0.019). No dif-
Neuroradiology, Greifswald, Germany; 5 University Medicine Mainz,
ference between pharmacotherapy groups were found for oddball
Neuroanatomy, Mainz, Germany
* Corresponding author. duration MMN.
Conclusions.– To sum up, only amplitude of MMN elicited by
Background and aims.– Culminating evidence points to a crucial multi-feature but not oddball paradigm were able to differen-
role of neural homeostasis in maintenance of mental health. In tiate between different pharmacotherapy subgroups. Reduced
keeping the balance between hypo- and hyperexcitability at the amplitudes of duration, density and brightness MMN elicited by
glutamatergic synapse plasticity related gene 1 (PRG-1) provides an multi-feature paradigm provides insight into interaction between
important feedback loop by regulating lipid phosphate signaling. impaired auditory processing and responsiveness to first and sec-
In vitro experiments of a partial deletion of PRG-1 have resulted ond line antipsychotic treatments.
in an increased excitability of the glutamatergic synapse. In vivo Disclosure of interest.– The authors have not supplied a conflict of
heterozygous PRG-1 knock-out mice show impaired capacity for interest statement.
sensory gating, i.e. the filtering of redundant information before
relaying it to the cortex. Such deficits in sensory gating have
oftentimes been associated with psychiatric disorders such as E-PP0704
schizophrenia. The effect of psilocybin on
In this study we aimed at replicating the results of the mouse plasticity-related genes and proteins
domain in human subjects, thus validating the animal model in the rat brain
and linking glutamatergic hyperexcitability of the human cortex O. Jefsen* , K. Højgaard, B. Elfving, G. Wegener, H.K. Müller
to impaired sensory gating as an endophenotype of psychiatric Translational Neuropsychiatry Unit, Department of Clinical Medicine,
pathology. Risskov- Aarhus, Denmark
Methods.– We identified heterozygous carriers of a naturally occur- * Corresponding author.
ring but rare loss-of-function-variant of PRG-1 and invited them for
a set of electrophysiological tests. These comprised a double-click- Background and aims.– The psychedelic compound psilocybin
EEG- and prepulse-inhibition-EMG-paradigm. has recently shown a large therapeutic potential for treatment-
Results.– Sensory gating was impaired in the healthy human cohort resistant depression, anxiety and addiction, in combination with
carrying the loss-of-function variant of PRG-1. psychotherapy. The supporting neurobiological mechanisms are
Conclusions.– The endophenotype of cortical glutamatergic hyper- currently not known, but have been suggested to rely on the acute
excitability in healthy subjects parallels the one found in patients induction of neuroplasticity. We aimed to capture a snapshot of
suffering from psychiatric illness. this postulated “boost” in neuroplasticity by measuring immedi-
Disclosure of interest.– The authors have not supplied a conflict of ate early genes related to synaptic plasticity, synaptic proteins and
interest statement. neurotrophic factors after a single administration of psilocybin.
We included several different doses to determine dose-response
relationships.
E-PP0703 Methods.– Rats were given a single, intraperitoneal injection of
Effects of optimizing auditory psilocybin. Focusing on prefrontal cortex and hippocampus, we
stimulation paradigm on MMN have examined levels of immediate early genes and proteins, using
qPCR and Western blotting, respectively. We will isolate synaptoso-
amplitude in schizophrenia patients
mal fractions and measure the expression and complex-formation
M. Jarkiewicz1* , Ł. Okruszek2 , A. Wichniak1
1 of pre- and postsynaptic proteins using two-color fluorescence
Institute of Psychiatry and Neurology, Third Department of
immunoblotting and dual immunoprecipitation, to study the acute
Psychiatry, Warsaw, Poland; 2 Institute of Psychology, Polish
effects of psilocybin on receptor trafficking and synaptic regulation.
Academy of Sciences, Clinical Neuroscience Lab, Warsaw, Poland
* Corresponding author. Results.– Results are currently being analyzed and will be presented
at the conference.
Background and aims.– Reduced MMN amplitude is a robust finding Conclusions.– Psilocybin has shown a large therapeutic potential
in schizophrenia. for treating depression and has sparked a revival in the field of
Most of the studies contributing to the research on MMN in psychedelic research. The results from our studies will likely moti-
schizophrenia has applied oddball paradigms with sinusoidal vate further investigations into the signaling pathways induced by
tones. psilocybin and, in the future, help identify novel pharmacological
The aim of this study was to investigate whether more targets for efficient treatment strategies for a range of psychiatric
complex stimulation can be more informative, than typical odd- illnesses.
ball paradigm, to study impairment in auditory processing in Disclosure of interest.– The authors have not supplied a conflict of
schizophrenia. interest statement.
E-PP0705 Alzheimer’s disease (AD) Nonfluent variant of PPA (Nf V-PPA) were
A high-density ERP study of social characterized by motor speech apraxia and phonetic distortion,
cognition in schizophrenia and while semantic variant PPA were characterized by impaired com-
prehension, naming and object knowledge. Lv-PPA patient had
attention deficit hyperactivity deficits in lexical retrieval and long sentenses repetition. Brain MRI
disorder showed anterior temporal lobe atrophy and fronto-insular atro-
B. Kakuszi* , B. Szuromi, M. Baradits, I. Bitter, P. Czobor phy supporting semantic and Nfv-PPA. Both CBD and AD patients
Semmelweis University, Psychiatry and Psychotherapy, Budapest, had, at presentation, non-fluent aphasia with buccofacial apraxia
Hungary and amnesic syndrome respectively. Brain MRI showed asymmet-
ric parietal atrophy in CBD. The SPECT showed hypoperfusion on
the corresponding area of each DPA.
Background and aims.– Social cognition plays a key role in inter-
Conclusions.– By using physiopathological markers, such as CSF
personal relationships, and its impairment leads to fundamental
markers, it is now possible to establish a biological diagnosis of
changes in social behavior, and disturbed social interactions.
AD in these focal cortical syndromes, and to propose a specific
Deficits in executive functioning are crucial in the develop-
treatment for them.
ment of social interaction problems, which characterize patients
with schizophrenia and Attention Deficit Hyperactivity Disorder
interest statement.
(ADHD).
Our aim was to investigate the neurobiological background of
impairments in social cognition in schizophrenia and ADHD using E-PP0707
brain event-related potentials (ERP).
Methods.– Participants were 21 schizophrenia and 46 ADHD
Emotional modulation of early visual
patients, and 34 healthy controls, matched for age, gender and edu- responses in major depression and
cation. High-density EEGs were recorded by a 256-channel BioSemi bipolar disorder
ActiveTwo system, and P200 responses were measured while sub- E. Mnatsakanian1 , V. Krjukov2 , O. Antipova2 , V. Krasnov2*
1 Institute of Higher Nervous Activity and Neurophysiology RAS,
jects performed a complex visual Go/NoGo task. Social cognition
was measured by the “Reading the mind in the eyes” test (RMET). HHNA lab, Moscow, Russia; 2 Moscow Research Institute of Psychiatry
The analysis was based on random-regression hierarchical linear - filial V Serbsky FMRCPN, Dept of affective disorders, Moscow, Russia
modeling. P200 amplitude was the dependent variable; diagnostic
group and % errors on the RMET and interaction served as indepen-
dent variables. Background and aims.– We aimed at studying the differences in
Results.– Compared to HCs, patients with schizophrenia and ADHD brain activity of patients with major depressive disorder (MDD)
had significantly (p < 0.05) diminished ERP amplitude with a and bipolar disorder (BD), recorded in implicit emotion recognition
topographically-specific distribution. The amplitude reduction in task. Threatening stimuli activate the defensive reactions, leading
ADHD was most pronounced in the temporo-parietal region. Lower to faster association between the warning and target stimuli. Our
ERP amplitude in the temporo-parietal region in all groups was experiment was designed to elicit the unconscious expectation of
associated with lower performance in social cognition, as measured neutral vs. negative emotional stimuli and analyze the ERP modu-
by the %errors on the RMET. lation.
Conclusions.– Deficits in social cognition both in schizophrenia and Methods.– 16 patients with MDD (10 female), 16 patients with BD
ADHD may be related to the abnormally reduced activity of the (8 female), and 16 healthy controls (9 female) took part in our
temporo-parietal neural networks, which have been reported to study. The patient groups didn’t differ in both Hamilton Anxiety and
underlie social cognition impairments. Depression Rating Scales. The EEG in patients was recorded before
Disclosure of interest.– The authors have not supplied a conflict of the treatment of their depressive episode was started. Participants
interest statement. had to sort 160 photographs as humans or animals. Half of the
photographs were neutral and half were showing angry/aggressive
people or animals. Simple patterns (the cues) were presented 2s
E-PP0706 prior to the pictures and their association with photographs was
not explained. We recorded 128-channel EEG and analyzed the
Degenerative progressive aphasia: a
cue-elicited ERPs. The difference waves between the neutral and
clinical, neuropsychological and emotional conditions represented the emotional modulation (EM).
neuroimaging in a 10 patients series Results.– Our participants learned the cue-picture association
N. Farhat, F. Kharrat* , O. Hdiji, S. Sakka, H. Hajkacem, M. Damak, C. unconsciously. Comparison of EMs between groups showed dif-
Mhiri ferences (p < .05) in P100 component in posterior areas between
Habib Bourguiba-University Hospital, Neurology, Sfax, Tunisia patients and healthy controls. The EM of component peaking at
170–180 ms differed between MDD and BD patients.
Conclusions.– The groups of patients were not large but comparable
Background and aims.– The neuropsychological categorization of
in their depression and anxiety rates. Unconscious emotional mod-
patients presenting with progressive aphasia is an area of contro-
ulation of ERPs may be a candidate biomarker for differentiating
versy. The aim of the study was to characterize a group of patients
certain kinds of psychopathology.
with degenerative progressive aphasia (DPA), clinically by language
impairment, and by morphological and scintigraphic imaging.
interest statement.
Methods.– We retrospectively queried and analyzed the cases of
patients with DPA. Neuropsychological examination was based on
a standardized battery of tests and a speech-language assessment.
Brain MRI and perfusion scintigraphy (SPECT) were performed.
Acquired (non-degenerative) aphasias were excluded.
Results.– Ten right handed-patients (7 males, 3 females), with
a mean age of 65.85 years, were identified. Of the 10 cases, 5
were diagnosed with primary progressive aphasia (PPA), three
with Cortico-Basal Degeneration (CBD) and the two others as
E-PP0708 people (total of 80). We recorded 128-channel EEG and analyzed the
Unconscious emotional modulation of evoked brain activity elicited by faces and facial expressions. The
evoked electrical brain activity to difference waves between the neutral and emotional conditions
represented the emotional modulation (EM).
warning stimulus in males with Results.– The EM (p < 0.05) was observed in P100 component in both
bipolar and schizotypal disorders patient groups but not in healthy controls. The EM in components
E. Mnatsakanian1 , V. Krjukov2 , V. Krasnov2* N170, N250, and P280 was quite similar in topography on the scalp
1 Institute of Higher Nervous Activity and Neurophysiology RAS, for controls and schizotypal disorder, while it was not observed
HHNA lab, Moscow, Russia; 2 Moscow Research Institute of Psychiatry in schizophrenia at these latencies. The N450 and Late Positive
- filial V Serbsky FMRCPN, Affective disorders, Moscow, Russia Complex both showed EM in controls and schizotypal disorder. In
schizophrenia, the EM was found in N450 only.
Conclusions.– Our results indicate that EM in schizotypal disorder
Background and aims.– In our work, we investigated the emotional
exhibits a general resemblance with EM in healthy controls at the
modulation (EM) that occurs in visual brain evoked response to
latencies longer than 130 ms. We can suggest that certain steps of
warning stimulus (cue) as a result of implicit learning during which
facial expression processing are preserved in schizotypal disorder.
the association is established between a cue and specific image
However, at the earlier latencies, the EM in schizotypal disorder has
category (neutral and angry faces).
more in common with schizophrenia than with healthy controls.
Methods.– Only male participants took part in our study: 13 patients
with bipolar disorder, 11 patients with schizotypal disorder, and
interest statement.
51 healthy volunteers. The EEG in patients was recorded before
the treatment started. Participants had to sort 160 photographs
as humans or animals. Half of the photographs were neutral, and E-PP0710
half were showing angry/aggressive people or animals. Simple pat-
terns (the cues) were presented 2s before the pictures, and their
Cognitive improving properties of
association with photographs was not explained. We recorded 128- cariprazine, a dopamine D3 receptor
channel EEG and analyzed the cue-elicited ERPs. The difference preferring partial agonist: overview of
waves between the neutral and emotional conditions represented non-clinical and clinical data
the EM. I. Laszlovszky1* , B. Kiss2 , Á. Barabássy1 , B. Szatmári1 , N. Adham3 ,
Results.– The effects of EM (p < 0.05) were observed in several com- G. Németh1
ponents of the evoked visual response to the cue, starting from 1 Gedeon Richter Plc., Medical Division, Budapest, Hungary; 2 Gedeon
the early component peaking around 80 ms. For the component Richter Plc., Pharmacological and Drug Safety Research Division,
peaking around 200–220 ms, and in some degree also for the com- Budapest, Hungary; 3 Allergan, External Science and Innovation,
ponents peaking at 120 ms and 300 ms, the EM in patients with Madison, NJ, USA
schizotypal disorder was similar to EM observed in controls, and * Corresponding author.
the distinctions were rather quantitative. In the case of patients
with bipolar disorder, we found qualitative EM differences from Background and aims.– Cognitive impairment is closely linked with
healthy controls. the severity of negative symptoms, and improvement of cogni-
Conclusions.– Our preliminary results (small sample size for tion can be beneficial in the treatment of negative symptoms
patients) suggest more severe distortion in certain aspects of of schizophrenia. Cariprazine is a potent dopamine D3 receptor-
emotional processing and implicit learning in bipolar than in preferring partial agonist approved by EMA and FDA for the
schizotypal disorder. treatment of schizophrenia, and by FDA also for bipolar mania and
Disclosure of interest.– The authors have not supplied a conflict of mixed episodes. It proved superior over risperidone in the treat-
interest statement. ment of predominant negative symptoms of schizophrenia.
The objective is to explore non-clinical and clinical features of
cariprazine to improve cognitive performance of patients with
E-PP0709 schizophrenia by targeting dopamine D3 receptors.
Early emotional modulation in brain Methods.– Data from non-clinical in vitro receptor binding studies,
activity elicited by angry faces in human PET studies, in vivo animal studies on cognitive perfor-
mance, and cariprazine clinical trials were analyzed to provide
patients with schizotypal disorder and evidence of how D3 receptor occupancy correlates with improve-
schizophrenia ments in cognition in schizophrenia.
E. Mnatsakanian1 , V. Krjukov2 , N. Maslenikov3 , E. Tsukarzi3 , V. Results.– In the in vitro binding assays cariprazine displayed high
Krasnov2* affinity for human dopamine D3 and D2 receptors with about 6-
1 Institute of Higher Nervous Activity and Neurophysiology RAS,
8 fold selectivity for D3 receptors. In patients with schizophrenia,
HHNA Lab, Moscow, Russia; 2 Moscow Research Institute of PET studies showed high occupancy at both D3 and D2 receptors at
Psychiatry - filial V Serbsky FMRCPN, Affective disorders, Moscow, therapeutic doses and confirmed cariprazine’s D3 occupancy and
Russia; 3 Moscow Research Institute of Psychiatry - filial V Serbsky selectivity in vivo. In an animal model of schizophrenia cariprazine
FMRCPN, Psychopharmacotherapy, Moscow, Russia reversed the phencyclidine-induced cognitive impairment in wild-
type but not in the D3 receptor knock-out mice. Cariprazine treated
patients with schizophrenia showed significantly greater improve-
Background and aims.– Facial expression recognition is distorted in
ment in cognitive factor scores than placebo or risperidone treated
schizophrenia. The schizotypal disorder can be considered a mild
patients.
form of schizophrenia, sharing some features but showing better
Conclusions.– Non-clinical and clinical data confirmed that
preservation of prefrontal brain regions. We investigated the dif-
dopamine D3 receptor in vivo activity of cariprazine may strongly
ferences in visual brain evoked responses to neutral and angry faces
be involved in its cognitive improving properties.
in patients with schizophrenia and schizotypal disorder.
Methods.– Only male participants took part in our study: 18 patients
interest statement.
with paranoid schizophrenia, 17 patients with schizotypal disorder,
and 55 healthy volunteers. Participants had to give a differential
motor response to photographs of neutral and angry/aggressive
E-PP0711 Results.– A 25-year-old male patient, admitted in a Psychiatry ser-

Post-infection dementia and vice in consequence of his first psychotic episode in comorbidity
Psychosis with cannabinoid abuse, whose parents both had a long-standing
C. Lazzari* , T. Rajanna, A. Nusair, J. Lyall diagnosis of schizophrenia, the maternal grandmother was diag-
Fieldhead Hospital- Southwest Yorkshire NHS Trust, Psychiatry, nosed with obsessive-compulsive disorder and he was adopted in
Wakefield, United Kingdom early childhood by a second degree cousin with no psychiatric his-
* Corresponding author. tory registered.
Conclusions.– The family history of this patient corroborates the
Background and aims.– There is a growing literature suggesting the conclusions described in the literature. Studies suggest that OCD,
possible effect of generalized infections in worsening or triggering schizophrenia and other spectrum disorders of schizophrenia are
dementia and psychosis in the elderly. The authors hypothe- based on a common genetic etiology, that a family history of OCD is
size that generalized and severe infections might cause dementia associated with an increased risk of schizophrenia in the offspring
and psychosis in vulnerable older adults. A typical case is here and that OCD may be considered a precursor to schizophrenia.
described. Moreover, individuals with both parents with schizophrenia have
Methods.– The case reported refers to a 64-year old woman who a risk of over 20% of developing the disease, and the genetic com-
developed symptoms of early dementia and psychotic depres- ponent is estimated to account for 80% of the total susceptibility to
sion after a major operation for moderate volume ascites and develop the disease.
pneumoperitoneum with gastrointestinal perforation resulting Disclosure of interest.– The authors have not supplied a conflict of
in generalized sepsis. Assessments included Addenbrooke-ACE-R, interest statement.
brain MRI, and neuropsychiatric testing.
Results.– Brain MRI was positive for a moderate degree of small-
vessel disease. Addenbrooke’s ACE-III provided the following E-PP0713
results: Total score 74/100: Attention = 18/18, Memory = 18/26, Flu- Cognitive functioning in patients with
ency 5/14, Language = 20/26 and Visuospatial = 13/16. The case obsessive-compulsive personality
index was doubly incontinent and started misplacing objects in the disorder
kitchen, confusing the use of familiar objects, and having difficul- A. Chepeliuk1* , M. Vinogradova2 , V. Barabanshikova3
ties in word finding. Along with this presentation, she continued to 1 Moscow State University, Clinical Psycholgy, Moscow, Russia; 2
have auditory-commanding hallucinations to harm herself, believ- Moscow State University, Clinical psychology, Moscow, Russia; 3
ing deriving from people passing by her house, delusional feelings Moscow State University, Psychology of Work and Engineering
of guilt, believing that people outside her house were gossiping Psychology, Moscow, Russia
about her, presenting tactile hallucinations, presuming that her * Corresponding author.
food was poisoned and that one of her daughters was a fake.
Although she was kept on regular Risperidone (5/mg daily) and Background and aims.– The cognitive rigidity, preoccupation with
Mirtazapine (45/mg daily) her presentation did not improve. details, need for control are the main characteristics of cognitive
Conclusions.– The authors speculate that severe and generalized impairment in patients with obsessive-compulsive personality dis-
infections in the elderly are likely to exert a significant impact order (OCPD). The degree of severity of these impairments can vary
on the brain grey and white matter hence triggering irreversible depending on different factors, including, in particular, character-
dementia and psychoses in vulnerable adults. istics of stimulus material.
Disclosure of interest.– The authors have not supplied a conflict of Objectives.– To research the performance of verbal and non-verbal
interest statement. tasks in patients with OCPD.
Methods.– Wechsler Adult Intelligence Scale, a revised form (WAIS-
R). 33 patients with OCPD and 102 healthy individuals were
enrolled to the study. Patients and healthy controls had an equiv-
E-Poster Presentation: Obsessive-Compulsive alent educational level. Statistical significance was ascertained by
Disorder Mann-Whitney U-test.
Results.– Patients with OCPD demonstrated decreases in the Per-
formance (p = 0.003) and the Full Scale IQ (p = 0.004), the Digit span
E-PP0712 (p = 0.008), the Picture completion (p = 0.0001) and the Block design
Obsessive-compulsive disorder, (p = 0.001) subtests. Reduction in the verbal subtest was associ-
schizophrenia and psychosis in ated with a shift in patients’ attention from tasks instruction to
thoughts of failure, strengthening of doubts of one’s own perfor-
comorbidity with cannabinoid abuse - mance. The diminishment of productivity in non-verbal subtests
the history of a family 3 in 1 was associated with preoccupation with details that led to a long
A.M. Carvalheiro* , J. Maia time for the right answers, which went beyond the time allocated
Centro Hospitalar de Leiria, EPE, Psychiatry, Leiria, Portugal to each item, detailed analysis of parts with difficulties in their syn-
thesis in the whole, impossibility of revising of the work method,
doubts about tasks precision often with the reversal of correct
Background and aims.– Although obsessive-compulsive disorder
answers.
(OCD) and schizophrenia are considered distinct nosological enti-
Conclusions.– Cognitive functioning in OCPD lines up with most of
ties, studies suggest a substantial overlap of their pathophysiology.
normative indicators in performance of verbal tasks and decreases
Using as a starting point a clinical case, the authors performed a lit-
in the case of non-verbal tasks.
erature review on the subject in order to clarify if a family history
of OCD is a risk factor for schizophrenia and other disorders of the
interest statement.
schizophrenia spectrum.
Methods.– The analysis of the patients clinical processes and a brief
review of the literature, based on the research of scientific articles,
published in PubMed, between 2013 and 2018, using as keywords
the terms “obsessive-compulsive”, “schizophrenia”, “family” and
“parents”.
E-PP0714 ied, with special interest on changes in OCD severity –assessed by

Treatment-resistant the Y-BOCS-, quality of life and secondary side effects.
obsessive-compulsive disorder and Results.– (1) See Table 1
Table 1. Sociodemographic and clinical variables.
neurosurgery management. A case
report
M. Jiménez Cabañas* , A. García Carpintero, B. Rodado León, Í.
Alberdi Páramo, F.J. Gómez Beteta, C. Carrascosa Carrascosa
Hospital Clínico San Carlos, Institute of Psychiatry, Madrid, Spain
Introduction.– We present a 42-year-old man with severe
obsessive-compulsive disorder (OCD) refractory to treatment of
20 years of evolution, accompanied by delirious thoughts, depres- (2) Long-term side effects were generally well tolerated although
sive symptoms and high anxiety. His daily routine has been 5 patients (22%) presented manic states forcing hospitalization.
limited by obsessions and compulsions (fears and repetitive (3) A significant improvement on quality of life was detected in 20
thoughts, facial grimaces and muscular contractions in front from 22 patients (90%).
of the mirror...), and he has required multiple hospitalizations
and therapies (psychopharmacological, psychotherapeutic, elec- Conclusions.– DBS constitutes a safe and effective therapeutic
troconvulsive therapy), without any improvement. In July 2018, alternative in the long-term for severe resistant OCD patients.
neurosurgical procedure was applied (bilateral stereotactic ante- Although DBS’s acute adverse effects are generally mild, transient
rior capsulotomy). and reversible information about the long-term management is
Objectives.–To review indications and results of neurosurgery in limited.
patients with severe and refractory OCD. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– Literature review of scientific papers searching in interest statement.
Pubmed and Medline. We considered papers in English and Span-
ish.
E-PP0716
Results.– After the surgery, the patient progressively improves the
obsessive-compulsive component, and the anxiety that caused him. Duloxetine augmentation in resistant
Then rehabilitation has started with support from Psychiatry and obsessive-compulsive disorder: a
Neurosurgery. The final results will be checked after 6–24 months double-blind controlled clinical trial
after surgery. However, the overall change observed so far is favor- A. Mowla
able. Shiraz University of Medical Sciences, Psychiatry, Shiraz, Iran
Several studies have demonstrated the importance of assessing
neurosurgery in patients with these characteristics, since there is Background and aims.– The aim of this study is to evaluate the
a significant deterioration in quality of life and this surgery could efficacy of duloxetine augmentation in treatment of resistant
result in a significant improvement of these patients. obsessive-compulsive disorder (OCD).
The criteria for neurological surgery in patients diagnosed with Methods.– This augmentation trial was designed as an 8-week
OCD are: chronicity and presence of disabling symptoms, inability randomized controlled, double-blind study. Forty-six patients
to maintain a normal life and failure of all treatments. Addition- experiencing OCD who had failed to respond to at least 12 weeks of
ally, it is needed the consent of the patient and the reports of two treatment with a selective serotonin reuptake inhibitor (fluoxetine,
independent psychiatrists indicating that the criteria are met. citalopram, or fluvoxamine) were randomly allocated to receive
Conclusions.– Surgery results seem promising so far, although more duloxetine or sertraline plus their current anti-OCD treatment. The
research about is needed. Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was the primary
Disclosure of interest.– The authors have not supplied a conflict of outcome measure. Treatment response was defined as 25% or more
interest statement. decrease in scores of Y-BOCS. The mean dosage of duloxetine was
44.4 mg/d (range, 20–60 mg/d), and the mean dosage of sertraline
was 123.8 mg/d (range, 50–200 mg/d).
E-PP0715 Results.– Forty-six patients (24 of 30 in duloxetine group and 22
Ten-year outcomes for deep brain of 27 in sertraline group) completed the trial. Both groups showed
stimulation in severe resistant improvement during the 8-week study period (mean Y-BOCS total
score at week 8 as compared with baseline: P < 0.001 & P < 0.001)
obsessive-compulsive disorder: a without significant difference (P = 0.861). Those receiving duloxe-
prospective descriptive study tine plus their initial medications experienced a mean decrease of
L. Mar Barrutia 33.0% in Y-BOCS score, and the patients with sertraline added to
Hospital de Bellvitge, Department of Psychiatry, Barcelona, Spain their initial medication experienced a mean decrease of 34.5% in
Y-BOCS.
Background and aims.– Deep Brain Stimulation (DBS) is a therapeu-
Conclusions.– Our double-blind controlled clinical trial showed
tic alternative for the treatment of patients with severe resistant
duloxetine to be as effective as sertraline in reducing obsessive
Obsessive-Compulsive Disorder (OCD). DBS allows focal, reversible
and compulsive symptoms in patients with resistant OCD. How-
and adjustable neuromodulation with around 60%, and reductions
ever, it needs to be noted that our study is preliminary, and larger
in severity of symptoms around 45%1. It is generally a well-
double-blind placebo-controlled studies are necessary to confirm
tolerated technique, with reversible adverse effects. There is little
the results.
data about long-term evolution of DBS-treated patients.
Aims.– To describe long-term follow-up of a sample of OCD patients
interest statement.
treated with DBS in the last ten years in an OCD specialized clinic
in Barcelona.
Methods.– 22 patients with a DSM-IV TR diagnosis of OCD, treated
with DBS for 5,1 ± 3,4 years (range: 2–11 years) at the OCD Clinical
and Research Unit of the Hospital de Bellvitge from 2007 to 2018
were included. Sociodemographic and clinical variables were stud-
E-PP0717 Results.– The initial sample consists of 15 patients, mainly female

Obsessive-compulsive (60%), with a mean age of 40 ± 14.5 years, employed (53%), with a
symptomatology in anxiety and mean duration of the illness of 17.3 ± 14.8 years. Patients have a
poor level of personal functioning (GAF: 62.8 ± 10.6) and a mod-
depressive disorders: the influence of erate severity of OC symptoms (Y-BOCS:23.0 ± 7.7). Participating
recent life events and traumatic relatives are mainly parents (47%) or spouse (27%), with a mean age
events of 56 ± 12.7 years. Relatives adopt problem-oriented coping strate-
A. Orozco1* , G. Lahera2 gies, such as positive communication (3.5 ± 0.6) and patient’s social
1 Psychiatrist, Hospital Universitario Príncipe de Asturias, Alcalá de involvement (3.4 ± 0.6), more frequently than emotion-focused
Henares, Spain; 2 Psychiatrist, Universidad de Alcalá. CIBERSAM, ones, such as avoidance (1.2 ± 0.5). Relatives report low levels of
Alcalá de Henares, Spain objective (1.3 ± 0.5) and subjective burden (2.0 ± 0.8).
* Corresponding author. Conclusions.– Our findings should be considered as preliminary and
suggest that relatives of OC patients have lower levels of family
Background and aims.– In Psychiatry, comorbidity is the rule more burden and cope better with the desease.
than the exception. This study aims to evaluate the presence of Disclosure of interest.– The authors have not supplied a conflict of
obsessive-compulsive symptoms (OCS) in a sample of anxious- interest statement.
depressive outpatients, analysing the influence of traumatic and
recent life events.
Methods.– Through an observational analytic study, a total of 200 E-PP0719
anxious-depressive outpatients was included by consecutive sam- A systematic review and meta-analysis
pling. Patients were evaluated during the first visit (time 1) and
after 6–12 months (time 2). The clinical assessment included: The
of technologically-delivered cognitive
MINI Interview, HAM-A and HAM-D, the Obsessive-Compulsive behavioural therapy interventions for
Inventory for OCS, the Dissociative Experience Scale-II, the Recent obsessive-compulsive disorder in
Life Changes Questionnaire and the Posttraumatic Stress Diagnostic adolescents and adults aged 10–65
Scale. Generalized linear mixed models (GLMMs) were used. years
Results.– OCS was present in 54% of the total sample. 30.5% of J. Redmore* , K. Corrigan, O. Duthie, S. Nixon, J. Ramage, F. Reilly
the subjects reported one or more traumatic events in their lives. University of Aberdeen, School of Medicine, Aberdeen, United
Moreover, 25% of the total sample reported dissociative experi- Kingdom
ences. During time 1, the presence of OCS was associated with * Corresponding author.
the presence of depression (p = 0,028), traumatic events (p = 0,000),
posttraumatic stress symptomatology (p = 0,000) and with the Background and aims.– Obsessive-Compulsive Disorder (OCD) is a
number of recent life events (p = 0, 0001). During time 2, the pres- common psychiatric condition, and severely impacts upon patient
ence of OCS maintained the association with posttraumatic stress quality of life. NICE recommends cognitive behavioural therapy
symptomatology and with the number of recent life events (p = 0, (CBT) as first-line treatment for mild-to-moderate OCD. However,
0001). The presence of OCS was associated with the presence of patients often experience extensive waiting-times before receiv-
dissociative experiences in a very robust way (p = 0,000). ing treatment. Recent technological advances may alleviate this,
Conclusions.– The presence of OCS in anxious-depressive out- along with other barriers to accessibility. This systematic review
patients is frequent (54%) and associated with the severity of and meta-analysis examined the effectiveness of technologically-
depressive symptomatology, the presence of traumatic events and delivered CBT (TCBT) versus waiting-list and face-to-face CBT
with a greater number of recent life events. controls in improving OCD symptom severity in those aged 10–65
Disclosure of interest.– The authors have not supplied a conflict of years.
interest statement. Methods.– Cochrane CENTRAL, Ovid-Embase, Ovid-Medline and
Ovid-PsycINFO were searched. Papers were then limited to
pre-defined inclusion/exclusion criteria. Reviewers independently
E-PP0718 assessed risk of bias, and extracted qualitative and quantitative data
Families of patients with obsessive in duplicate, using a unique template based on the CONSORT Guide-
compulsive disorder: results from an lines, SIGN Checklist and Cochrane Risk of Bias tool. The primary
outcome was OCD symptom severity post-intervention, assessed
observational study
via random-effects meta-analysis
C. Palummo* , B. Pocai, M. Savorani, G. Borriello, G. Sampogna, V.
Results.– Eight studies comprising 742 participants were included.
Giallonardo, M. Gravagnone, V. Del Vecchio, M. Luciano, A. Fiorillo,
Compared with waiting-list controls, TCBT yielded greater
F. Perris
improvements in OCD symptoms for both adolescents [weighted
University Of Campania Luigi Vanvitelli, Psychiatry, Naples, Italy
* Corresponding author. mean difference −4.25, 95% CI −6.89 to −1.60, p = 0.002] and adults
[weighted mean difference −4.81, 95% CI −8.22 to −1.40, p = 0.006].
Background and aims.– Obsessive compulsive disorder (OCD) is a Further, these improvements were clinically significant in most
severe mental disorder associated with high levels of personal, studies. TCBT was found to be non-inferior to face-to-face CBT
social and family burden. In particular, family members of patients [mean difference 1.27, 95% CI −2.31 to 4.85, p = 0.49], albeit based
with OCD report low levels of quality of life and limitations in on one study
daily functioning. However, a few studies have evaluated coping Conclusions.– This systematic review and meta-analysis found con-
strategies adopted by relatives of patients with OCD. sistent evidence that TCBT lessens the severity of OCD symptoms
Objectives.– To describe the levels of family burden and coping versus waiting-list controls. A paucity of research exists comparing
strategies in a sample of relatives of patients with OCD. TCBT to face-to-face CBT, which future studies should address
Methods.– In the period January-September 2018, all patients with Disclosure of interest.– The authors have not supplied a conflict of
OCD and their relatives attending the outpatient unit at the Univer- interest statement.
sity of Campania “Luigi Vanvitelli” have been invited to participate.
Validated assessment tools have been administered to patients and
relatives in order to evaluate the levels of symptomatology, per-
sonal functioning, family burden and coping strategies.
E-PP0720 the dimensions of caregiver burden, associated factors and cop-

Obsessive- compulsive disorder ing strategies in Turkish immigrant women who look after their
associated with Fahr’s disease:a case mothers with AD.
Methods.– Semi-structured in-depth interviews were held with
report eight Turkish immigrant women who look after their mothers with
S. Memis1 , C.O. Memis2 , L. Sevincok2*
1
AD. Participants were recruited between June 2017-May 2018 from
Aydin State Hospital, Psychiatry, Aydin, Turkey; 2 Adnan Menderes
a Centre of Transcultural Psychiatry in Hannover/Germany. Audio
University, Psychiatry, Aydin, Turkey
recordings were typed out and qualitative content analysis was
used to analyze the data.
Background and aims.– Fahr’s disease, also known as familial idio- Results.– Caregiver role was undertaken unconditionally as a
pathic basal ganglia calcification, is considered to be one of the rare cultural responsibility independent of the premorbid mother-
neurological diseases that is characterized by abnormal calcified daughter relationship. A predeath grief response which results
deposits in basal ganglia and cerebral cortex. Patients with Fahr’s in denial and guilt was commonly encountered. Participants
disease often appear with movement disorders, such as parkinson- frequently suffered from sleep disturbances and other somatic
ism, paresis, dystonia, and speech impairment. Psychosis, mood symptoms along with deterioration of social and family life. Con-
disorders, and dementia may occur [2]. Several endocrine abnor- flicts between the caregivers and other family members due to
malities were found to be associated with Fahr’s disease, especially unmet expectations existed. Despite the aforementioned adver-
with regard to calcium metabolism. sities, they specified the caregiving to their mothers rather as a
We here present a case of Fahr’s disease associated with obsessive- positive/satisfactory experience. Negative attitudes towards formal
compulsive disorder (OCD) (1,2). care were present. Caregiver burden was specifically higher as the
Methods.– 35 years old female patient. When she was 30 years old, individualistic elements in the identity (higher acculturation to the
she was admitted to emergency service because of a head trauma. In German culture) were more prominent.
her Computerized Brain Tomography examination, calcified lesions Conclusions.– Culturally sensitive interventions which target
were observed in basal ganglia. She was diagnosed as Fahr’s Syn- predeath grief process and acculturation issues should be imple-
drome in neurology department with bitemporal hemianopsia and mented in order to decrease the caregiver burden in Turkish
abnormal PTH results. A few months later, checking and wash- immigrant women who look after their mothers with AD in
ing compulsions emerged. She was administrated paroxetine, at Germany.
60 mg/d, with a moderate improvement in her OC symptoms. Disclosure of interest.– The authors have not supplied a conflict of
Results.– Psychiatric symptoms, as often seen in diseases of the interest statement.
basal ganglia, e.g., Parkinson’s, Wilson’s, and Huntington’s diseases,
are thought to be due to disruption of cortical-subcortical circuits
E-PP0722
mediated by the basal ganglia. Lesions in the orbitofrontal anterior
cingulate system or the connecting lateral orbitofrontal circuit can Under-diagnoses of late-life
produce OCD4. depression in North Greece
Conclusions.– IWe here present a Fahr’s Syndrome case presenting K. Argyropoulos1 , A. Saropoulou1 , A. Argyropoulou2 , D.
OC symptoms. We suggest that OCD occurred due to basal ganglia Avramidis3* , E. Jelastopulu1
1 School of Medicine, University of Patras, Public Health, Patras,
lesions in this patient.
Disclosure of interest.– The authors have not supplied a conflict of Greece; 2 Health Centre of Andravida, Family Medicine, Patras,
interest statement. Greece; 3 University of Patras, Greece, School of Medicine, Patras,
Greece
E-Poster Presentation: Old Age Psychiatry - Part I Background and aims.– Depression is the most frequent cause of
emotional suffering on late life.
The purpose of the present study was to estimate the prevalence
E-PP0721 of Late-Life Depression and to assess possible under-diagnoses of
depressive symptoms in the elderly.
Turkish immigrant women as Methods.– A cross-sectional study was conducted among the
caregivers of their mothers with members of the open day care centres for older people in the
Alzheimer’s disease in Germany: municipality of Pella, North Greece. A questionnaire was developed
preliminary findings of a qualitative to collect basic demographic data, including three questions from
study the “European Health Interview Survey”, regarding self-reported
U. Altunoz1* , E.T. Ozel-Kizil2 , G. Bastug3 , G. Topcu4 , T. Agar5 , O. and/or by a physician diagnosed depression. Moreover, to all par-
Yavuz6 , I.T. Graef-Calliess1 ticipants the Greek validated version of the Geriatric Depression
1 KRH Wunstorf Psychiatric Hospital, Psychiatry and Psychotherapy, Scale (GDS-15) was applied, to screen the elderly for depressive
Wunstorf, Germany; 2 Ankara University School of Medicine, symptoms.
Department of Psychiatry, Geriatric Psychiatry Unit, Ankara, Turkey; Results.– A total of 241 individuals took part in the study. Accord-
3 Ankara University, Vocational School of Health, Ankara, Turkey; 4 ing to the GDS, 34.9% of the participants revealed having depressive
Hacettepe University, Deptartment of Social Work, Ankara, Turkey; 5 symptoms, 27.4% moderate and 7.5% severe type. Having ever been
Wahrendorf Clinic, Transcultural Psychiatry and Psychotherapy, affected with chronic depression reported 20.3%, of them 71.2%
Hannover, Germany; 6 Dokuz Eylul University, Department of had been diagnosed by a medical doctor and 28.9% had received
Psychology, Izmir, Turkey antidepressant medication. Of the 160 subjects who reported never
* Corresponding author. been affected by a depression, 26.9% and 3.8% screened positive for
moderate and severe depressive symptoms, respectively. In eight
Background and aims.– Prevalence of Alzheimer’s Disease (AD) is individuals who reported not to know if they have/had depression,
increasing among aging Turkish immigrants in Germany. The nec- depressive symptoms were observed in 85.7% applying the GDS-15.
essary care is provided mostly by family members, predominantly Conclusions.– Late-Life Depression in North-Greece show a high
daughters of the patients. There is a great paucity of research con- prevalence and appears to be an under-diagnosed disease. The
cerning the burden faced by those women. We aimed to investigate
application of GDS-15 by general practitioners would increase their Methods.– The patients were examined once in the form of a struc-
ability to detect and treat depression. tured interview, at the stage of relief of acute symptoms and
Disclosure of interest.– The authors have not supplied a conflict of preparation for discharge.
interest statement. The sample consisted of 155 patients of gerontopsychiatry depart-
ment, mean age 68.11 ± 8.074 years. In the sample studied, affective
disorders predominated (66%), less common were organic brain
E-PP0723 diseases (19%), neurotic and stress-related disorders (14%).
Association between the adherence to Results.– The breakdown in health before discharge was observed
the mediterranean dietary pattern in 40.1% of the patients examined, which was manifested by exac-
erbation of the main syndrome (25.4%), onset of new symptoms
and common mental disorders among
(0.8%), somatic decompensation (1.6%) or by a combination of the
community-dwelling elders from São aforementioned events (12.3%). We found no significant correla-
Paulo, SP, Brazil tion between the breakdown in health prior to discharge and the
A. A Bastos* , L.R. Nogueira, R.M. Fisberg, S.M. Lima Ribeiro primary diagnosis, concomitant diseases, sex or age, marital sta-
University of São Paulo, School of Public Health, São Paulo, Brazil tus or social situation. Nevertheless, the nature of relations with
close ones was a significant factor. We revealed significant correla-
tions between the sentiment of pity (correlation coefficient: 0.63,
p < 0.05) and feeling of guilt (0.47) towards the closest person (fam-
Introduction.– Studies have shown that Mediterranean dietary pat-
ily member or friend), and the prevailing avoidance strategy when
tern (MDP) adherence may contribute to protect against common
resolving conflicts with this person (0.642).
mental disorders (CMD). However, this relationship is poorly inves-
Conclusions.– Psychosocial factors such as relations with close ones
tigated in Brazilian elderly people.
can influence the dynamics of the patient’s condition at the stage
Aims.– To investigate the association between the adherence to
of end of treatment and preparation for discharge.
the MDP and CMD in elderly, after adjusting for sociodemographic
variables.
interest statement.
Methods.– Cross-sectional, population-based study, including 545
elders (≥60 y; both genders) from São Paulo, SP, Brazil. The
CMD was identified by Self Reporting Questionnaire (SRQ-20), E-PP0725
and MDP adherence was determined using Mediterranean Diet
Assessment and management of
Score (MDS; from two 24 h food records). Forward stepwise
logistic regression models were used to evaluate the association behavioral and psychological
between CMD and MDP adherence (Model 1 = crude associations; symptoms of dementia
and Model 2 = adjusted for gender, age, BMI, marital status, number W. Bouattour* , S. Omri, M. Daoud, R. Feki, M. Maalej Bouali, J. Ben
of comorbidities, education, household income, physical activity Thabet, N. Charfi, L. Zouari, M. Maalej
and smoking status). Simple logistic regression models were used University Hospital Center Hedi Chaker, Department of Psychiatry C,
to decide the order of inclusion of the variables in the multiple Sfax, Tunisia
regression in adjusted models (Stata software, v.14).
Results.– The participants showed a moderate adhesion to MDP
(mean score = 4.01 ± 0.77). From the adjusted regression models Background and aims.– Behavioral and psychological symptoms of
(Model 2), maintaining the low adherence as reference, a moder- dementia (BPSD) represent a heterogeneous group of non-cognitive
ate and a high adherence to the MDP was associated to a lower symptoms and behaviors occurring in subjects with dementia. They
prevalence of CMD [OR = 0.54 (95% CI = 0.34–0.88) for moderate constitute a major component of the dementia syndrome. This
adherence and OR = 0.42 (95% CI = 0.18-0.98) for high adherence]. study aims to evaluate the BPSD and to assess their management.
Conclusions.– Our sample showed an intake defined as “moder- Methods.– A retrospective study, involving 45 diagnosed patients
ate adherence to MDP”. The moderate and high MDP adherences with dementia (DSM 5) and followed in the psychiatry depart-
showed to be protective against CMD. These results highlight the ment of Hedi Chaker University Hospital in Sfax (Tunisia) between
importance of programs directed to a healthy diet by elders. January 2016 and September 2018. Sociodemographic, clinical and
Disclosure of interest.– The authors have not supplied a conflict of therapeutic data was collected from their medical records.
interest statement. Results.– The mean age was 75.6 years (range 52–95 years), with a
sex-ratio of 0.7. The different types of dementia were Alzheimer’s
disease (77.8%), vascular dementia (20%) and fronto-temporal
E-PP0724 dementia (2.2%). Nearly two-thirds of patients (75.6%) had at least
one BPSD, 26.6% had ≥4 symptoms. Most frequent BPSD were
Microsocial environment as predictor
delirium (55.6%), agitation (53%), hallucinations (51%), aggres-
of breakdown in health shortly before siveness (38%). Mood disorders, apathy, anxiety and disinhibition
discharge were least frequent. Nearly one-third (31%) of patients were on
I. Beltceva1* , N. Zalutskaya2 , N. Neznanov2 cholinesterase inhibitors, 56% were on atypical antipsychotics, 20%
1 Bekhterev National Research Medical Center for Psychiatry and were on antidepressant and 24.4% were on benzodiazepine. The
Neurology, Department of Geriatric Psychiatry, St. Petersburg, Russia; majority of cases (71.1%) were on polytherapy with psychotropic
2 Bekhterev National Research Medical Center for Psychiatry and
drugs. Adverse drug reaction monitoring has been determined only
Neurology, department of geriatric psychiatry, Saint-Petersburg, for 39.5% of patients.
Russia Conclusions.– BPSD occur on as dementia evolves, regardless of the
dementia type. Their care is not always suited to recommendations.
Improving our recognition and management of BPSD is considered
Background and aims.– A frequent phenomenon in clinical prac-
necessary because it can have a positive impact on the quality of
tice is a medically unmotivated breakdown in the patient’s health
life of our patients and potentially delay the transition from home
shortly before discharge.
to institutional care.
The purpose of study was to reveal psychosocial predictors of devel-
opment the phenomenon of deterioration of well-being of elderly
interest statement.
patients shortly before discharge.
E-PP0726 77%, respectively, with a cutoff of 5/6 for the diagnosis of depres-
Factors associated with three-year sion.
mortality in elderly people with mood Conclusions.– The results support the validity and the applicability
of the 8-item GDS for older people in the context of institutional-
disorders ization.
C. Chen* , Y.J. Pan
Far Eastern Memorial Hospital, Department of Psychiatry, New Taipei
interest statement.
City, Taiwan R.O.C.
E-PP0728
Background and aims.– There is a lack of clarity in the literature
regarding the longitudinal risk factors associated with mortality Screening for behavioural and
in elderly people with mood disorders (including bipolar disorder psychological symptoms of dementia
(BD) and major depressive disorder (MDD)). with the Abe’s BPSD score:
Methods.– Elderly people diagnosed with and treated for mood dis- preliminary results of the Portuguese
orders in 2008 were identified from the National Health Insurance
Research Database in Taiwan and were followed up for the consecu-
validation study
A.R. Ferreira1* , A. Sá2 , M. Capela2 , S. Timóteo2,3 , M.R. Simões4 , L.
tive three years (2008–2011). Survival analyses were conducted to
Fernandes1,2,3
examine the risk factors associated with mortality over a three-year 1 Faculty of Medicine- University of Porto, CINTESIS – Center for
follow-up period.
Health Technology and Services Research, Porto, Portugal; 2 São João
Results.– A total of 26,570 elderly patients diagnosed with and
Hospital Center, Clinic of Psychiatry and Mental Health, Porto,
treated for mood disorders in 2008 were enrolled in this study,
Portugal; 3 Faculty of Medicine- University of Porto, Clinical
among whom 5,854 were BD patients, and 20,716 were MDD
Neurosciences and Mental Health Department, Porto, Portugal; 4
patients. A total of 4,048 patients died within the three-year follow-
Faculty of Psychology and Educational Sciences- University of
up period, including 1,003 BD patients and 3,045 MDD patients.
Coimbra, Psychological Assessment Laboratory, Coimbra, Portugal
Comorbid dementia was associated with an around 40% increase * Corresponding author.
in the mortality risk. Among comorbid physical illnesses, diabetes
mellitus and renal disease each constituted an elevated relative risk Background and aims.– Behavioural and psychological symptoms of
of mortality. On the contrary, having diagnoses of hypertension and dementia (BPSD) are among the most distressing, time-consuming
hyperlipidemia appeared to have protective effects. and costly aspects of dementia care. Some instruments have been
Conclusions.– Those elderly patients treated for mood disorders proposed to accurately identify BPSD, as a first step to developing
were at a fairly high risk of mortality over a three-year follow- effective interventions, of which the Neuropsychiatric Inventory
up period. While comorbid mental and physical illnesses generally (NPI) is the most widely used. Nevertheless, NPI imposes some lim-
contributed to an elevated risk, diagnoses of hypertension and its, mainly concerning its completion time. In this context, the Abe’s
hyperlipidemia were shown to be negatively associated with the Score (ABS) was recently proposed as an alternative measure.
mortality risk. Early detection, better control and risk prevention To present the preliminary results of the ABS Portuguese validation
for physical and mental illnesses are important to improve prog- study.
nosis of mood disorder in elderly patients. Methods.– ABS is being cross-validated with the NPI-12 and the
Disclosure of interest.– The authors have not supplied a conflict of Mini-Mental State Examination (MMSE) in dyads of patients and
interest statement. carers consecutively referred for neuropsychiatric assessment in
an outpatient psychogeriatric setting of a University Hospital.
Patients ≤65 years and with a major psychiatric diagnosis are being
E-PP0727
excluded. ABS internal consistency, concurrent and convergent
Validation of the geriatric depression validity were analysed.
scale in a sample of institutionalized Results.– Thirty dyads were included. Patients are mainly women
older adults of the portuguese (73.3%), with a mean of 79.57 ± 5.96 years and a global moderate
level of cognitive impairment (MMSE 19.21 ± 6.28). Concern-
population
ing carers, they are mainly female (66.7%), with an average of
C. Duarte1* , C. Madeira-Sério1 , F. Daniel1 , L. Lemos1 , D. Falcão2 , H.
61.23 ± 13.18 years. A mean score of 21.94 ± 21.74 was obtained
Espírito Santo1
1 Instituto Superior Miguel Torga, Psychology, Coimbra, Portugal; 2 for NPI, while 8.40 ± 7.96 was scored for ABS. Significant correla-
tions were found between ABS and MMSE (rs = −0.531, p < 0.01),
Casa de Saúde Rainha Santa Isabel, Psychology, Coimbra, Portugal
* Corresponding author. and ABS and NPI (rs = 0.808, p < 0.01). An ␣ = 0.598 was estimated.
Conclusions.– Despite the preliminary nature of these findings, the
Background and aims.– Research shows a high prevalence of depres- ABS seems to be a promising brief measure of BPSD.
sive symptoms in institutionalized older people when compared Acknowledgements.– Supported by FCT (PD/BD/114555/2016),
to the ones living in the community. Studies suggest the impor- ERDF through operation POCI-01-0145-FEDER-007746 funded by
tance of regular screening for depression to promote an increase COMPETE2020, National Funds through FCT within CINTESIS,
in quality of life of institutionalized older adults. This investigation R&DUnit (ref. UID/IC/4255/2013).
aims to validate the Geriatric Depression Scale (GDS) in a sample Disclosure of interest.– The authors have not supplied a conflict of
of institutionalized older people. interest statement.
Methods.– 493 institutionalized older people, with ages above
of 60 years old, were assessed through the GDS, the Mini-
International Neuropsychological Interview (M.I.N.I.), the Geriatric
Anxiety Inventory (GAI), the Positive Affect (PA) and Negative Affect
(NA) Schedule and the Satisfaction With Life Scale (SWLS).
Results.– The statistical analysis achieved to a final version of eight
items. The internal consistency of the 8-item GDS presented a Cron-
bach’s alpha of 0.87 and a single-factor structure. ROC analysis
showed an AUC of 0.82, with sensibility and specificity of 80% and
E-PP0729 Inventory (CMAI). Final analysis of data was possible for 75 subjects.
Facilitating the access to cognitive Statistical significance of test results was at p ≤ 0,05.
screening assessment in elderly Results.– 34 subjects with MCI converted to dementia, while 41 did
S. Gergely1* , P. Brandoburová2 , S. Krakovská1 , J. Plichtová3 not develop dementia during the observation period. Patients who
1 MEMORY Centre n.p.o., Department of Clinical Psychology, converted presented greater intensity of behavioural symptoms in
Bratislava, Slovak Republic; 2 2. Department of Neurology, Medical all four subscales of CMAI. Moreover, either global score, or results
School of Comenius University and University Hospital, Department in physical non-aggressive and verbal aggressive behavioural
of Clinical Psychology, Bratislava, Slovak Republic; 3 Comenius subscales of CMAI were associated with cognitive functions’ dete-
University, Faculty of Social and Economic Sciences, Bratislava, rioration during the first year of observation.
Slovak Republic Conclusions.– Prevalence and greater intensity of aggressive and
* Corresponding author. impulsive behaviour is an unafavourable prognostic factor in mild
cognitive impairment. Main limitations of the study are the use
Background and aims.– Cognitive screening assessment in elderly is of MMSE as a scale of little sensitivity in the identification of MCI
the useful tool to improve access to early dementia diagnosis. The patients who can develop dementia and no additional adjustment
most vulnerable group in terms of the changes of cognitive health of results for concomitant treatment.
are the people in the age of 60 years and above. Disclosure of interest.– The authors have not supplied a conflict of
Data from cognitive screening assessment were analysed to iden- interest statement.
tify the mediators and the barriers of the professional help seeking
process.
Methods.– Cognitive screening assessment is provided in MEMORY E-PP0731
Centre N.P.O. since 2012. Overall 442 assessments were provided Postoperative delirium development
in 2017 and analysed in follow up procedure. The presented sample associated with metabolic alterations
consisted of 331 adults from 60 to 91 years (M = 72,7, SD = 7,3) with following hemi-arthroplasty in elderly
approximately 72% women, with 14 years of education in average Y. Guo1* , Y. Li1 , Y. Zhang2 , S. Fang3 , X. Xu1 , A. Zhao2 , J. Zhang1 , W.
(SD = 3,2). Jia2 , W. Jiang1
Results.– 44,7% underwent the assessment because of the subjective 1 Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,
perceived memory decline followed by 19,7% because of the refer- Department of Anesthesiology and Critical Care Medicine, Shanghai,
ral by significant other with only 6,6% referred by the professional. China; 2 Shanghai Jiao Tong University Affiliated Sixth People’s
The cognitive impairment of various severity was present in 61,2% Hospital, Center for Translational Medicine, Shanghai, China; 3
with the average duration of symptoms 12–36 months before the Shanghai Ninth People’s Hospital Affiliated with Shanghai Jiao Tong
assessment initiation. As the most disturbing symptom forgetful- University School of Medicine, Department of Anesthesiology and
ness of the familiar names and the inability to recall familiar terms Critical Care Medicine, Shanghai, China
in speech was mentioned. * Corresponding author.
Conclusions.– To improve the early diagnosis of cognitive impair-
ment to shorten the period of decision process in help seeking Background and aims.– Postoperative delirium (POD) is a common
and more intense cooperation with the professionals is needed. and harmful complication following surgery in elderly and possible
The results will serve as the baseline for the intervention pro- link between metabolic changes during perioperative period and
gramme created to raise the awareness of dementia in Slovakia POD development is yet to be investigated.
and to decrease the perceived stigma of the disorder. Methods.– A nested case-control study was performed through
This project was supported by the Slovak Research and Develop- metabolomics to find the metabolic changes associated with POD.
ment Agency under the Contract APVV-17-0536. 244 elderly hip-fracture patients who had hemi-arthroplasty were
Disclosure of interest.– The authors have not supplied a conflict of recruited and their delirious states were assessed for three days
interest statement. after surgery. Simultaneously, fasting blood samples were collected
on the morning of surgery and on the first postoperative day. The
blood samples from 60 patients with POD and 60 matched controls
E-PP0730 were analyzed using ultra-performance liquid chromatography
Aggressive and impulsive behaviour is quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS)
an unafavourable prognostic factor in and gas chromatography time-of-flight mass spectrometry (GC-
TOF-MS).
mild cognitive impairment
Results.– Eighteen metabolites differed between the 2 groups before
J. Grabowski* , M. Przybylak, T. Piasecki, L. Bidzan
surgery, and twenty-three metabolites differed between the 2
Medical University of Gdansk, Department of Developmental-
groups after surgery. Similarly, thirty metabolites in POD group
Psychotic and Geriatric Psychiatry, Gdansk, Poland
* Corresponding author. differed before and after surgery, and thirty-two metabolites in
NPOD (Non-POD) group differed before and after surgery. After
Background and aims.– Mild cognitive impairment (MCI) is an estab- retrieved KEGG database, our data indicated that, in POD group,
lished risk factor for development of dementia. Research so far ␻3 and ␻6 fatty acids were lower than NPOD group at both before
showed that the presence of neuropsychiatric symptoms is asso- and after surgery, intermediates of tricarboxylic cycle were lower
ciated with more rapid deterioration of cognitive functions in than NPOD group but products of glycolysis were higher than NPOD
patients with dementia. Our aim was to establish the relation group after surgery, branched-chain amino acids (BCAAs)/aromatic
between aggressive and impulsive behaviour and cognitive func- amino acids (AAAs) ratio was lower than NPOD group after surgery.
tions’ decline in subjects with MCI. Conclusions.– Deficiencies of ␻3 and ␻6 fatty acids, abnormal
Methods.– We recruited 193 outpatients with a diagnosis of MCI oxygen metabolism, metabolic imbalances in BCAAs/AAAs, may
confirmed by criteria established by Working Group on MCI. Those potentially diminish the brain’s inherent protective capacity and
subjects were systematically observed during a 7-year prospective hence could contribute to the POD development.
study with regard to possible development of dementia. Assess- Disclosure of interest.– The authors have not supplied a conflict of
ment of cognitive functions was based on Mini Mental State interest statement.
Examination (MMSE), while aggressive and impulsive behaviour
intensity was examined with the use of Cohen-Mansfield Agitation
E-PP0732
Reducing the risk of dementia with
exercise, a state-of-the-art review and
consideration of practical
implementation
S. Hussain1* , J. Ye1 , T.J. Robb1 , S. De Souza2
1 University of Bristol, Medical School, Bristol, United Kingdom; 2
Somerset Partnership NHS Foundation Trust, Old Age Psychiatry,
Taunton, United Kingdom
Background and aims.– Dementia is a progressive neurodegener-

ative disorder, characterised by deterioration in higher cortical
function. The burden of disease is high, with approximately 500,000
diagnosed cases of dementia in the UK alone. Figure 1. Pearson’s correlation of total score of SMCQ with others
The study aimed to establish the evidence for exercise as a poten- covariates.
tially modifiable risk (PMR). To propose possible interventions to
Conclusions.– Discrepancy between subjective memory complaints
improve population engagement in this PMR.
and cognitive impairments suggests that depressive disorders
Methods.– Three student researchers reviewed a range of ran-
including minor depressive disorder and subsyndromal depression,
domised control trials, and observational studies. The aim of the
might play a role in the subjective memory complaints rather than
review was to establish if there was adequate evidence to jus-
cognitive impairments in community-dwelling elderly. Treatment
tify recommending physical exercise to patients, to reduce their
for the depressive disorders should be considered in dealing with
risk of dementia. Students devised their own search strategies to
the subjective memory complaints in the elderly.
be used across a range of search engines, including Ovid-Medline,
Google Scholar and PubMed. Students then critically appraised the
interest statement.
generated literature.
Results.– A review of the literature found several limitations in the
studies looking at risk reduction in dementia. However, overall E-PP0734
the evidence pointed to an association between increased physical
The attitude of elderly towards aging
activity before the onset of dementia, and a reduction in the risk of
developing dementia. The literature could not prove a causal link and its’ relatedness with the notion of
however, they did offer valid proposed mechanisms of action. forgiveness
Conclusions.– Overall the review concluded that there was ade- M. Karvela1* , S. Mantzoukas2 , I. Vlachos3 , E. Kotrotsiou3 , M.
quate evidence to justify advising people that there is an association Gouva1
1 University of Ioannina, Research Laboratory Psychology of Patients
between increased physical activity and the reduction in risk of
dementia. The students, using this research, developed public Families and Health Professionals, Ioannina, Greece; 2 University of
health interventions which aim to encourage patients to increase Ioannina, Research Laboratory Integrated Care, Health and
engagement in physical activity. The presentation will outline these Wellbeing, Ioannina, Greece; 3 TEI of Thessaly, Postgraduate Program
interventions, and how their development has progressed since the “Primary Health Care”, University of Thessaly, Larisa, Greece
review was completed.
interest statement. Background and aims.–
Background.– The notion of forgiveness has been linked to condi-
tions that increase the levels of quality of life.
E-PP0733 Aim.– The overall objective of this research study was to investigate
the relationship between the notion of forgiveness amongst elderly
A study on factors affecting subjective
individuals and their attitudes towards aging within the context of
memory complaints among the primary health care.
elderly in the community Methods.– A cross-sectional study was performed. A total of 192
Y.M. Jae* , L. Kyoung Hwan older people participated to the present study from the regions of
Bongseng Hospital, Psychiatry, Busan, Republic of Korea Epirus, Thessaly and Central Greece. The participants’ age ranged
from 69 to 85 years. The questionnaire included: a) question for
the recording of attitudes towards aging based on free association
Background and aims.– To investigate the factors affecting subjec-
methods, b) the Heartland Forgiveness Scale (HFS) and c) questions
tive memory complaints among the elderly in urban area.
for the social-demographic parameters.
Methods.– The subjects of this research were 160 community-
Results.– One way ANOVA and MANCOVA was used for statistical
dwelling elderly without dementia and major depressive disorder.
analysis. Results did not show significant differences in forgiveness
Each subject was administered the questionnaires regarding the
of the older people in terms of sex, age and marital status. The GLM
socio-demographic characteristics, Korean version of subjective
analysis found a predominantly strong associations between of the
memory complaints questionnaires (SMCQ), Korean version of
attitude of the elderly towards aging and forgiveness total (HFS)
short geriatric depression scale (sGDS) and Korean version of
(p = .008), forgiveness of self (HFS) (p = .185), forgiveness of others
Mini-mental state examination (K-MMSE). Subjective memory
(HFS) (p = .003) and forgiveness of situations (HFS) (p = .003).
complaints were defined as above 5 points of SMCQ.
Conclusions.– The results of the present study highlighted that for-
Results.– 39.38% of the subjects had subjective memory complaints.
giveness is a dynamic situation that contributes to well aging.
There were significant associations between subjective memory
Therefore, it may be worthwhile the notion of forgiveness becomes
complaints and Sgds (p < 0.001), physical illness (p = 0.001), but
integrated within welfare and caring programs.
there was no association with MMSE (p = 0.383) (Fig. 1).
interest statement.
E-PP0735 ideators and attempters compared to controls. Ideators were more

Autoantibodies to S100 protein and likely to be male, require carer support and have substance related
myelin basic protein as predictors of disorders, while attempters were often widowed, had trauma and
stressor related disorders, diseases of the eye and lacked social con-
poorer prognosis in patients with nectedness. Attempters were also more likely to be female and be
mild cognitive impairment without carer support.
G. Kostyuk1* , M. Kurmyshev2 , O. Karpenko3 , V. Savilov4 Conclusions.– These results indicate risk profiles that can be utilised
1 Mental Clinic No 1 named after N.A. Alexeev, Administration, in inpatient settings to identify older adults at risk of suicide
Moscow, Russia; 2 Mental Clinic No 1 named after N.A. Alexeev, ideation and attempts. Post-discharge programs can focus on a
Mental Despensary No 15, Moscow, Russia; 3 Mental Clinic No 1 variety of risk factors such as depression, substance abuse, trauma
named after N.A. Alexeev, Education Center, Moscow, Russia; 4 Mental related disorders, factors associated with decline in vision and psy-
Clinic No 1 named after N.A. Alexeev, Memory Clinic, Moscow, Russia chosocial problems. Specifically social connectedness and carer
support were important psychosocial factors.
Background and aims.– Cognitive impairment in elderly is a problem
interest statement.
of high significance due to the increasing prevalence. Comprehen-
sive cognitive rehabilitation programs (CCRP) are used to improve
cognitive functioning. At the initial level of cognitive decline, it is E-PP0737
not always possible to diagnose correctly the nature of cognitive
impairment and to predict the course of disorder. Immune markers
Overdosing of
assessment can bring the light to the severity of brain damage. benzodiazepines/z-drugs and falls in
Aims.– To assess dynamics of cognitive functioning before and after older adults: costs for the health
CCRP in patients with mild cognitive impairment (MGI) and its system
association with immune markers (leukocyte elastase, autoanti- M.J. Diaz-Gutierrez1 , M. Martinez-Cengotitabengoa2* , C.
bodies to S100 protein (abS100) and myelin basic protein (abMBP)) Bermudez-Ampudia3 , S. Garcia2 , P. Lopez2 , M.T.
levels. Martinez-Cengotitabengoa4 , A. Besga5 , A. Gonzalez-Pinto2
Methods.– Prospective study of unselected sample of patients with 1 Community Pharmacist, Pharmacy, Llodio, Spain; 2 CIBERSAM,
MCI. Patients (n = 61) were recruited in the outpatient public ‘Mem- BioAraba Research Institute- University of the Basque Country,
ory Clinic’ in Moscow. Exclusion criteria were depression and Psichiatry, Vitoria, Spain; 3 CIBERSAM-BioAraba Research Institute,
anxiety (HADS score >10), history of psychosis, acute somatic Metodology and statistic unit, Vitoria, Spain; 4 The Psychology Clinic
diseases. Immune markers were assessed in plasma at baseline. of East Anglia, Psychology, Norwich, Spain; 5 CIBERSAM- BioAraba
Cognitive parameters were assessed using Mini Mental State Exam- Research Institute- University of the Basque Country, Psychiatry,
ination (MMSE) at baseline and in 6 weeks, after completing CCRP. Vitoria, Spain
The difference in MMSE score >2 considered as clinically significant * Corresponding author.
improvement. Difference in immune parameters was compared in
groups with and without cognitive improvement using Pearson’s Background and aims.– Benzodiazepines and Z drugs (BZD/Z drugs)
2 test. are commonly used for the treatment of insomnia andanxiety in
Results.– Eighteen (29,5%) patients showed no significant improve- older adults for long periods of time. Given the physiological and
ment after CCRP. This correlated with more malignant immune metabolic characteristics of thisgroup of patients, they are more
profile in this group with significantly higher levels of autoanti- prone to the adverse effects of these drugs which include falls.
bodies then in patients with significant improvement (2 = 4.18, The re-commendations for use of BZD/Z drugs include the need
p < 0.05). to adjust the dose and select those with a short half-life, to avoid
Conclusions.– Levels of autoantibodies can be used as markers of adverse events, which as well as potentially affecting patient out-
more severe brain damage in patients with clinical picture of MCI. come, increase healthcare costs. In thisstudy, we have evaluated the
Disclosure of interest.– The authors have not supplied a conflict of hospital-related costs associated with falls in older adults who use
interest statement. BZD/Z drugs atdoses higher than recommended for this age group.
Methods.– We conducted a cross-sectional observational study
assessing the BZD/Z drug prescriptions of olderadults attending the
E-PP0736 emergency department after a fall. Cost analysis was performed for
Late-life suicide risk factors cases in which theprescriptions exceeded the maximum recom-
G. Kuruvilla1* , S. birtles2 , S. Bhar3 , H. Jayaram1 mended dose for this age group.
1 Eastern Health, Mental Health, Melbourne, Australia; 2 Swinburne Results.– A total of 40.6% of the prescriptions recorded were higher
University, Department of Psychological Medicine, Melbourne, than the defined daily dose in older adults (DDDolderadults). Of the
Australia; 3 Swinburne University, Department of Psychologiocal 57 patients who used BZD/Z drugs at higher-than-recommended
Sciences, Melbourne, Australia doses, 53 experiencedtrauma and 33 required hospitalisation. The
* Corresponding author. costs associated with emergency department services, tests per-
formed and hospitalisation amounted to D 1850/patient
Background and aims.– Older adults disproportionately die by Conclusions.– Appropriate dosage of BZD/Z drugs in older adults
suicide. This study investigated the unique and overlapping psy- could reduce both patient suffering and costs forthe health system.
chosocial risk factors associated with late-life suicide ideation and Disclosure of interest.– The authors have not supplied a conflict of
attempts for older adults admitted to an acute aged persons mental interest statement.
health unit
Methods.– A retrospective case control study to establish risk pro-
files of 135 older adults admitted following a suicide attempt.
Groups were compared on demographic data, clinical disorders,
personality disorders, general medical conditions and psychosocial
problems.
Results.– Higher rates of depressive disorders, psychosocial prob-
lems and past suicide attempts were found in older adult suicide
E-Poster Presentation: Old Age Psychiatry - Part Results.– The mean age of study participants was 70.11 years
III/Oncology and Psychiatry (SD = 5.5) and mean duration of PD was 8.3 years. Only 12.12% of
participants were professionally active. FS was found in 86.87% and
symptoms of depression were found in 62.63% of PD patients.
Conclusions.– FS was found in most of study participants, which
E-PP0738 occurs the more often the longer the PD lasts (p = 0.048). FS is asso-
The vogel-study wuerzburg: new ciated with a decrease in physical fitness and QOL. Physical activity
electrophysiological methods in the improves the QOL and limits the progression of PD. The level of
early diagnosis of Alzheimer’s disease health behaviors in non-frail is higher than in patients with FS
T. Polak* , A. Katzorke, T. Kiel, M. Fischer, M. Lauer, J. Deckert, M.J. (p = 0.027). The higher the level of health behaviors, the better the
Herrmann QOL
University Clinic Wuerzburg, Department of Psychiatry, Disclosure of interest.– The authors have not supplied a conflict of
Psychosomatics and Psychotherapy, Wuerzburg, Germany interest statement.
Background and aims.– E-PP0740

Objectives.– Alzheimer’s disease is still of increasing medical and Major depressive disorder and
socio-economic importance. Therapeutic approaches so far failed. physical capabilities in the elderly
One reason may be that most clinical trials so far started too late in W. Rachel1* , S. Krupnik2 , W. Datka3 , D. Dudek4 , M. Zak5
the course of disease. Today’s diagnostic tools for detection of pre- 1 Jagiellonian University, Collegium Medicum, Department of
clinical AD show some disadvantage regarding costs and invasivity Psychiatry, Cracow, Poland; 2 University of Physical Education,
and thus are problematic when applied in screening examination Department of Physical Education and Sport, Cracow, Poland; 3
of larger numbers of potential candidates for clinical trials. Jagiellonian University, Collegium Medicum, Departament of
Methods.– Within this context we developed methods such as near- Psychiatry, Crakow, Poland; 4 Jagiellonian University, Collegium
infrared spectroscopy (NIRS) and vagus-evoked potentials (VSEP) Medicum, Departament of Psychiatry, Cracow, Poland; 5 The Jan
combining all advantages of an ideal examination method. NIRS, in Kochanowski University, Faculty of Medicine and Health Sciences-,
addition, shows a high amount of ecologic validity and VSEP reflect Institute of Physiotherapy, Kielce, Poland
early disease-specific changes. For both methods, we and others * Corresponding author.
could show significant differences in subjects with AD and Mild
cognitive impairment (MCI) compared to healthy controls. If they Background and aims.– Comprehensive psychiatric evaluation
really are suited as a diagnostic tool for preclinical AD, that is the should also entail patients’ motoric and locomotion capabilities,
scope of the Vogel-Study Würzburg, a prospective long-term cohort as recommended by EPA. Patients with recurrent Major Depressive
study designed to evaluate the predictive validity of NIRS and VSEP Disorder (MDD) are generally acknowledged to have a number of
in the early diagnosis of AD. their functional capabilities appreciably diminished.
Results.– This study which since 2010 included 604 participants Assessing motoric and locomotion capabilities in the patients with
meanwhile started its second follow up. recurrent MDD.
Conclusions.– We not only present data of the baseline and the first Methods.– The assessment covered 71 MDD patients over 60 years
follow up examination, but also discuss methodic aspects of long of age. The subjects were stratified by GDS (Geriatric Depressive
term studies in AD. Scale), and assessed in terms of gait under a single- (TUG) and dual-
Disclosure of interest.– The authors have not supplied a conflict of task conditions, static balance with open and closed eyes (SLS OP,
interest statement. CL), and muscle strength (30sChS).
Results.– Applicable reference values for physical capabilities were
met by 6.9% −36.1% of the subjects, depending on a domain. Ref-
E-PP0739 erence values for TUGT under a single- and dual-task conditions
The impact of frailty syndrome on the were met by 34.7% and 6.9% of them, respectively, for SLS (OP, CL)
quality of life in patients with - by 23.6% and 2.7%, respectively, while for muscle strength - by
36.1% of them. GDS scores were found to be correlated with 30sChS
Parkinson’s disease – a preliminary
(rs = −0.26).
study Conclusions.– (1) MDD appreciably affected individual physical
A. Pytel capabilities. (2) Approx. 30% of MDD patients met pertinent ref-
Wrocław Medical University, Departament of Nervous System, erence values for physical capabilities. (3) Muscle strength affected
Wrocław, Poland MDD intensity as an independent factor.
Background and aims.– Parkinson’s disease (PD) is a progressive, Disclosure of interest.– The authors have not supplied a conflict of
neurodegenerative disorder results primarily from the death of interest statement.
dopaminergic neurons within the substantia nigra. Frailty syn-
drome (FS) is an important problem in older adults. FS combined
E-PP0741
with the symptoms of PD, can have a significant negative impact
on the quality of life (QOL). To assess the impact of FS on the QOL Weapon license and dementia
among PD patients. D. Religa1,2* , E. Schwertner1 , H. Soderstrom1 , J. Secnik1 , B.
Methods.– The study included 101 patients (59 women and 42 men). Winblad1 , M. Eriksdotter1
1 Karolinska Institutet, Department of Neurobiology, Care Sciences
All patients were classified as at least stage II according to the Hoehn
and Yahr scale. The study was conducted in the Circle of Friends and Society NVS, Stockholm, Sweden; 2 Karolinska University
of People with PD in Wroclaw. The following measurement tools Hospital, Theme Aging, Stockholm, Sweden
were used in the study: Schwab and England Activities of Daily
Living Scale (SEADL), the 39-item Parkinson’s Disease Question-
Background and aims.– In Sweden there is more than 600,000
naire (PDQ-39), the Beck’s Depression Inventory (BDI), the Tilburg
licensed firearm owners and approximately 170,000 patients with
Frailty Indicator (TFI), the Unified Parkinson’s Disease Rating Scale
dementia diagnosis. This study aims to explore properties of
(UPDRS).
firearm ownership in a large population of Swedish dementia
patients. The aim is to specify socio-demographic and clinical char- Disclosure of interest.– The authors have not supplied a conflict of
acteristics of dementia patients owning firearms, as well as factors interest statement.
influencing the decision to report a patient as non-suitable to pos-
sess firearms to authorities.
Methods.– This was a registry-based cohort study. Sample consisted E-PP0743
of patients diagnosed with dementia and registered in the Swedish Sex differences in behavioral and
Dementia Registry (n = 69,100). Eight subtypes of dementia were psychological symptoms in
included the study: Alzheimer Disease (AD), Mixed Dementia
frontotemporal dementia
(Mixed), Vascular dementia (VAD), Lewy body dementia (LBD),
E. Schwertner1* , M. Eriksdotter1,2 , B. Johansson2,3 , L. Minthon4 , B.
Frontotemporal dementia (FTD), Unspecified dementia (UNS) and
Winblad1,2 , D. Religa1,2 , K. Nagga4,5
Other types of dementia (Other). Logistic regression was used to 1 Karolinska Institutet, Neurobiology- Care Sciences and Society,
estimate odds ratio (OR) of being reported as non-suitable to pos-
Stockholm, Sweden; 2 Karolinska University Hospital, Theme Aging,
sess firearms to authorities in each dementia diagnoses with AD
Huddinge, Sweden; 3 Karolinska Institutet, Department of Molecular
as a reference. Final model was adjusted for age, sex, Mini-Mental
Medicine and Surgery, Stockholm, Sweden; 4 Lund University,
State Examination and, living arrangement and antipsychotics use.
Department of Clinical Sciences, Malmo, Sweden; 5 Linköping
Results.– In total 1,826 (3.4%) patients had weapon licence and 347
University, Department of Acute Internal Medicine and Geriatrics,
(10.2%) were reported to authorities. In adjusted models, VAD and
Linköping, Sweden
FTD were assosciated with increased risk of being reported as non- * Corresponding author.
suitable to possess firearms comparing to AD patients (OR = 1.41
95%CI (1.01–1.97) and OR = 4.18 (2.22–7.89), respectively). Background and aims.– Frontotemporal dementia (FTD) is a progres-
Conclusions.– Our results indicate that in the physicians’ opinion, sive condition associated with changes in behavior, loss of higher
FTD and VAD patients may pose a greater risk of committing vio- social skills and emotional perception. The aim of this study was to
lent act. We recommend and this should be included in future compare behavioral and psychological symptoms (BPSD) between
guidelines. males and females with FTD measured by Neuropsychiatric Inven-
Disclosure of interest.– The authors have not supplied a conflict of tory (NPI).
interest statement. Methods.– This was a registry-based cohort study. We stud-
ied patients diagnosed with FTD and registered both in the
Swedish Dementia Registry and the Swedish BPSD registry
E-PP0742 (n = 237). We used the 12 item version of NPI assessing fol-
Use of antidepressant in elderly: from lowing symptoms: Hallucinations, Delusions, Agitation/aggression,
current evidence to clinical practice Dysphoria/depression, Anxiety, Irritability, Disinhibition, Euphoria,
C. Romeromartin1* , P. Padilla Romero2 , T. López-Arteaga2 , M.T. Apathy, Aberrant motor behavior, Sleep and night-time behavior
Perez Castellano2 change, Appetite and eating change. Separate logistic regression
1 Hospital Nuestra Señora Del Prado, Hospital Pharmacy, Talavera de models for each symptom were built to estimate odds ratio (OR) of
la Reina, Spain; 2 Hospital Nuestra Señora Del Prado, Psychiatry, having symptoms amongst males and females.
Talavera de la Reina, Spain Results.– 55% of the study sample were females and 45% were males.
* Corresponding author. The mean (SD) age was 71.9 (9,1) years, mean (SD) Mini–Mental
State Examination (MMSE) score was 22.2 (5.8) points and the mean
Background and aims.– (SD) number of drugs was 3.2 (2.7). There were no significant dif-
Introduction.– In choosing an antidepressant in an older depressed ferences in clinical characteristics between the sexes. Compared
patients it is recommended that selection be based on the best side to females, males had a lower risk of anxiety (OR 0.51, 95% CI
effect profile, lowest risk of drug-drug interactions and pharma- 0.30–0.90). There were no other differences between females and
cokinetics profile in elderly. The aim of this study was to evaluate males regarding any of the other symptoms.
antidepressant prescription adequacy in institutionalized elderly Conclusions.– A higher risk of anxiety, but not of other BPSD in
based on the current evidence. female patients requires further studies. The lack of differences
Objectives.– Describe antidepressant prescriptions in a sociosan- in clinical characteristics may suggest an influence of other sex or
itary center and evaluate its adequacy according to the latest gender determinants that are not included in the present study.
guidelines for antidepressant prescription in elderly. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– Retrospective, descriptive and transversal study about interest statement.
the use of antidepressants in elderly that involved 114 institution-
alized patients 65 years of age and older. Evaluation of the adequacy
of antidepressants prescription was evaluated in based of: indica- E-PP0744
tion and dosage in elderly. We obtained data of: age, sex, diagnosis, The influence of psycho-social factors
antidepressant and dosage from the electronic prescription and
on the emergence of psychosis in
a computer-based medication prescription system for dispensing
drugs in the sociosanitary center. dementia
Results.– We included 114 institutionalized patients (60% women, A. Sidenkova
average age 87 [65–99]. 48,2% (n = 55) were receiving any antide- Ural State Medical University, Ekaterinburg, Russia
pressant: 32,7% (n = 18) trazodone, 27,2% (n = 15) escitalopram, Relevance.– Cognitive disorders are often found in modern popu-
18,1% (n = 10) mirtazapine, 11% (n = 6) paroxetine, 5,4% (n = 3) ven- lations. Mechanisms of development of dementia studied enough,
lafaxine, 3,6% (n = 2) sertraline and 1,8% (n = 1) fluoxetine. We so the relevance of studies of this issue is big. The purpose of this
detected 7,3% (n = 4) trazodone and escitalopram prescriptions study. The present study - the study of psychosocial and neuropsy-
using a higher than advised doses in elderly patients. chological mechanisms of the main manifestations of dementia
Conclusions.– There are more women institutionalized in geriatric Materials and methods. The present study is a prospective obser-
centers. Almost 50% percent of institutionalized patients were vational comparative study sample of patients with dementia in
taking any antidepressant. Trazodone and escitalopram were the Alzheimer’s disease and vascular dementia. In the study group
drugs most prescribed. Trazodone prescriptions using a higher than was 214 patients with dementia, they had family in the compar-
referred doses were detected in less than 10% in our sample. ison group was 101 patients, they lived in a rest home. Methods:
clinical, clinical -psychopathological, neuropsychological, psycho-

metric, sociometric and statistical.
Results.– For mild to moderate dementia symptoms affective spec-
trum (anxiety, irritability/unstable mood, gipotimiey), psychotic
symptoms (painful ideas, perception disorders), behavioral dis-
orders (agitation/aggression, aberrant motor activity, behavior
disorders night) have a greater degree and found significantly more
often (p.Conclusion.– Structure of psychoses dementia depends on
psychosocial factors.
interest statement.
E-PP0745
The efficacy of probiotics in patients
with dementia - a preliminary search
results of systematic review
K. Jasińska1 , D. Storman2* , M. Swierz2 , W. Staśkiewicz1 , M. Figure 1. Prisma 2009 flow diagram.
Górecka1 , A. Skuza1 , P. Toboła3 , M.M. Bala3
1 Student’s Scientific Group of Systematic Reviews, Systematic Conclusions.– This topic seems to be very unexplored which is why
high quality randomized controlled trials need.
Reviews Unit, Faculty of Medicine, Jagiellonian University Medical
College, Kraków, Poland; 2 Systematic Reviews Unit, Faculty of
interest statement.
Medicine, Jagiellonian University Medical College, Kraków, Poland; 3
Systematic Reviews Unit, Department of Hygiene and Dietetics,
Faculty of Medicine- Jagiellonian University Medical College, Kraków, E-PP0746
Poland
* Corresponding author. Randomized comparative study about
efficacy and tolerability of
Background and aims.– Dementia and pre-dementia states (such vortioxetine in behavioral alterations
as mild cognitive impairment) are increasingly prevalent in age- in elderly patients with Alzheimer’s
ing populations. Treatment is usually challenging and provides
minor effects. Probiotics and synbiotics may constitute a promising
disease at the local health unit of
additional therapy to improve brain functions and slow down the Alentejo
progression of dementia. M. Suárez Gómez* , S. Farinha, P. Barbosa, J. Isaac, P. Moura, A.
Our aim is to assess the efficacy of probiotics or synbiotics alone or Matos-Pires, P. Colaço, L. Caeiro
in combination in patients with dementia or pre-dementia states. Unidade Local de Saúde do Baixo Alentejo ULSBA, Psychiatry, Beja,
Methods.– Following a protocol which we will publish in PROSPERO, Portugal
we systematically searched electronic databases (Ovid MEDLINE,
Embase, CENTRAL, Web of Science) as well as clinical trials registers
Background and aims.– To evaluate the efficacy and tolerability of
(ClinicalTrials.gov, EU Clinical Trials Register, WHO International
vortioxetine in the treatment of behavioral alterations in elderly
Trials Registry Platform) using adequate search strategies with no
patients with Alzheimer’s disease.
restrictions on language and date. We will manually search refer-
Methods.– The sample will be composed of elderly patients with
ences to identify additional papers. All titles and abstracts of studies
Alzheimer’s diagnosis and behavioral changes followed in the Geri-
were reviewed independently by two reviewers and eligible full
atric Psychiatry team between September 2018 and March 2019.
texts were assessed similarly. Conflicts were resolved by discus-
Firstly, the patients are treated for at least two months with
sion or help from third reviewer. To assess risk of bias in included
donepezil, but presents behavioral changes, so initiates risperi-
studies we will use Cochrane Risk of Bias Tool 2.0 for RCTs and
done, after despite organic disease. It will be obtained the informed
ROBINS-I tool for CCTs.
consent and passed the socio-demographic questionnaire, Mini
Results.– We identified 3088 records (Fig. 1, 3071 from databases
Mental State, Geriatric Depression Scale (GDS) and BEHAVE-AD.
and 17 additional from clinical trials registers). After removing
Risperidone is maintained for two weeks and if there are clinical
duplicates, we screened 2548 references. We included 13 papers in
improvements, it is kept the therapy and the patients leaves the
general: 9 abstracts from electronic databases and 4 from registers
study; if there are no clinical improvements, vortioxetine is added
of clinical trials. Into qualitative analysis 7 studies was included.
and it is passed GDS and BEHAVE-AD.
Further results will be presented during the Congress.
After four weeks, the patient is reevaluated and passed the scales
again.
The data will be analyzed and the results of the three moments will
be compared.
Results.– The results will be published and presented in scientific
sessions.
Conclusions.– Pharmacological reatment for behavioral distur-
bances in elderly patients with Alzheimer’s Disease has shown
minimal efficacy or substantial adverse effects and should only be
continued if clinical benefit is obtained.
interest statement.
E-PP0747
Pharmacological treatment in increasing over time. It is therefore a long-term psychosis, with

behavioral disturbances in severe impairments in its psychopathology and in the social par-
ticipation of those affected, as well as a tendency towards chronicity
Alzheimer’s disease
and dysfunctionality. Nevertheless, it is associated with increased
M. Suárez Gómez* , S. Farinha, P. Barbosa, J. Isaac, P. Moura, A.
comorbidities, mortality, and cognitive impairment similar to those
Matos-Pires, P. Colaço, L. Caeiro
observed in normal aging, which may suggest accelerated patho-
Unidade Local de Saude do Baixo Alentejo ULSBA, Psychiatry, Beja,
logical aging.
Portugal
* Corresponding author. Conclusions.– There is a need for pharmacological treatment aimed
at reducing symptoms using antipsychotics with a lower increase
Background and aims.– Behavioral disturbances occur frequently in in cardiovascular risk and by routes of administration that have
Altheimer’s Disease. better adherence rates. All this is associated with psychoeducation
The prevalence varies greatly between studies due to the use of involving the carrier and the family, to avoid the risk of misuse
different definitions, but includes agitation, which may increases of psychotropic drugs and to decrease the, unfortunately com-
the severity and is often associated with psychosis or aggression, mon, rate of drug discontinuation. Concomitantly, psychotherapy
anxiety, and disinhibition. is installed to accompany the process of developing social skills
A lot of medications have been used to treat behavioral distur- in a diverse environment (work, family, leisure) to ensure patient
bances in patients with dementia but have shown minimal efficacy functionality over time.
or substantial adverse effects. Disclosure of interest.– The authors have not supplied a conflict of
The aim for this study was identify behavioral symptoms and the interest statement.
main pharmacological treatment in Alzheimer’s Disease.
Methods.– It was made a systematic review of scientific studies
of main scientific database about pharmacological treatment in E-PP0749
behavioral disturbances in Alzheimer’s Disease at the last 10 years. The relationship between oral health
Results.– In the treatment of agitation in patients with dementia, and psychopathology in elderly people
a proactive approach with recognition and treatment at an early C. Tsironis1* , E. Kotrotsiou2 , C. Hatzoglou3 , M. Gouva4
stage can prevent the excessive administration of psychotropic 1 Technological Educational Institute of Epirus, Research Laboratory
drugs. Psychology of Patients Families and Health Professionals, Ioannina,
Memantine may decrease agitation/aggression and irritability. Greece; 2 Research Laboratory of Care- T.E.I. of Thessaly- Larisa-
Clinical trials with Inhibitors Selective Serotonin Reuptake showed Greece, Nursing, Larisa, Greece; 3 Postgraduate Program “Primary
some usefulness in agitation and paranoia, given that the behavioral Health Care”- University of Thessaly- Larisa- Greece, Medicine, Larisa,
symptoms are often caused by a mood disorder and patients have Greece; 4 Technological Educational Institute of Epirus, Research
difficulty verbalizing their symptoms, but this has limited evidence Laboratory Psychology of Patients Families and Health Professionals-,
beyond the symptoms due to depression. Ioannina, Greece
Mood stabilizers have not shown evidence and benzodiazepines * Corresponding author.
should be limited to brief episodes.

Atypical antipsychotics have been the drugs of choice, but are asso- Background and aims.–
ciated with increased mortality and should not be routinely used. Background.– The psychopathology has been linked with low levels
Conclusions.– Treatment for behavioral disturbances in patients of quality oral health.
with dementia have shown minimal efficacy or substantial adverse Objectives.– This study examined the relationship between oral
effects and should only be continued if clinical benefit is obtained. health in older people and psychopathology.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– The total sample included 204 older people with a
interest statement. mean age 74.17 (SD = 7.06). The elderly people completed (a) The
Geriatric Oral Health Assessment Index (GOHAI), (b) the Symp-
tom Check-List Revised (SCL-90) and (c) questionnaire concerning
E-PP0748 socio-demographic information.
Aging and spectrum of schizophrenia: Results.– One way ANOVA and MANCOVA was used for statisti-
cal analysis. Results show significant differences in oral health
a psychiatric and psychological
of elderly people and economic status. High blood pressure was
approach found to directly contribute in the in increasing the quality of oral
Y. Takaki Konno1* , A. Bessa Marques Filho1 , É. Marques Kohl2 , T. health (F = 5.063, p = .006). Thus GLM analysis found strong associ-
Castro Molina3 ations between quality of oral health and Somatization (SCL-90)
1 Faculdade de Medicina de São José do Rio Preto, Psychiatry, São
(p = .012), Obsessive-Compulsive (SCL-90) (p = .017), Depression
Paulo, Brazil; 2 Faculdade de Medicina de São José do Rio Preto, (SCL-90) (p = .018), Anxiety (SCL-90) (p = .000), Aggression (SCL-90)
Psychiatry, São José do Rio Preto, Brazil; 3 Faculdade de Medicina de (p = .085), Phobic anxiety (SCL-90) (p = .000), Psychoticism (SCL-90)
São José do Rio Preto, Psychology, São José do Rio Preto, Brazil (p = .000).
Conclusions.– Our findings provide more detailed information on
the negative effects of psychopathology on quality of oral health in
Background and aims.– New studies on accelerated aging in patients
elderly people.
with schizophrenia are encouraging reassessment of how to diag-
nose and treat this portion of the population. This article proposes
interest statement.
an approach to aging in schizophrenia, with a psychiatric and psy-
chological cognitive behavioral view.
Methods.– Articles, citations and online books from the MEDLINE
database have been selected in recent years for the discussion of
accelerated aging in schizophrenia.
Results.– In meta-analysis, increased systemic biomarkers such as
inflammation, cytotoxicity, oxidative stress, gene expression and
synaptic function. Sociability is also compromised, with the risk of
death being higher than in the general population, which has been
E-PP0750 Conclusions.– The combined in- and out-patient psychotherapeu-

Immunological agents for tic group, where members continue their psychotherapeutic work
neurocognitive disorders- a review of after leaving the hospital (focusing on (i) the individual rea-
sons/losses that brought one to the hospital and remain “outside
the current evidence it”, (ii) the transitions from home to hospital environment and vice
O. Vasiliu
versa and (iii) the meaning of “being old”), offers members the
“Dr. Carol Davila” University Central Military Hospital, Psychiatry,
chance both to feel included and to reflect and embrace their tran-
Bucharest, Romania
sitive life situations both in their individual specificity and in the
Background and aims.– The shift from symptomatic approaches to universality of the broader “elderly community”, thus promoting
disease-modifying treatments for Alzheimer Dementia (AD) has autonomy.
lead to various results, some of them encouraging, other rather Disclosure of interest.– The authors have not supplied a conflict of
disappointing. interest statement.
This review try to establish the current stage of the AD immuno-
logical therapies development. E-PP0752
Methods.– A search of major electronic databases (Cochrane,
PubMed, PsychInfo, EMBASE) was performed, using keywords
Older women in breast cancer
“immunological therapies”, “beta-amyloid”, “tau-protein”, and remission: a structural model for
“Alzheimer’s disease”. Also, the database clinicaltrials.gov was ques- adjustment to aging
tioned using the same paradigm. S. Von Humboldt* , F. Carneiro, I. Leal
Results.– A number of 37 trials related to the immunological ther- ISPA-Instituto Universitário, William James Center for Research,
apies for AD were detected in the electronic databases. Finished Lisbon, Portugal
trials with published results were investigating a tau vaccine
(AADvac 1- positive results, phase 1 trial) and several vaccines
Background and aims.– Breast cancer is prevalent in old age and
directed against beta-amyloid plaques (ACC-001- negative results,
may affect adjustment to aging of older women. This study aimed
two phase 2A trials, gantenerumab- it may be efficient, but more
to build a structural model to explore the predictors of adjustment
trials are needed, bapineuzumab– failed, phase 3 trial, BAN2401-
to aging (AtA) reported by older women in breast cancer remission.
it was efficient in a single phase 2A trial, AN1792- phase 2A trial
Methods.– A community-dwelling sample of 771 older women in
produced positive effects and a follow-up after 4.6 years detected
breast cancer remission aged between 75 and 98 years answered
low anti-AN1792 antibody titers, and CAD106- only a phase 1 trial).
a questionnaire to determine socio-demographic (age, income,
A number of 4 studies targeting beta-amyloid are active or planned
marital status, education, household, and living setting), and
to begin soon (aducanumab, crenezumab, UB-311, BAN2401 and Lu
health-related characteristics (self-reported functional limitations
AF20513), one for tau-protein (AADvac 1), one for the combination
and disabilities, time since remission, other type of cancer, breast
of beta-secretase inhibitor inhibitor (BACE) and beta-amyloid vac-
reconstruction, perceived health, recent disease and medication).
cine (CNP520 and CAD106), and one comparison of BACE inhibitor
Several measures were employed to assess AtA, sense of coherence
versus beta-amyloid vaccine (CNP520 vs. CAD106).
and subjective well-being. Structural equation modeling was used
Conclusions.– The level of evidence for current immunological ther-
to explore a structural model of the self-reported AtA, encompass-
apies targeting AD is not very encouraging, but many trials are
ing all variables.
currently ongoing or will start in near future.
Results.– Significant predictors of AtA are self-reported disability
(ˇ = .404; p < .001), time since remission (ˇ = .371; p < .001), per-
interest statement.
ceived health (ˇ = .257; p < .001), other type of cancer (ˇ = .231;
p < .001), breast reconstruction (ˇ = .153; p = .008), marital status
E-PP0751 (ˇ = .141; p < .001), sense of coherence (ˇ = .140; p < .001), and living
setting (ˇ = .139; p = .006). These variables accounted for 84.3% of
In transition: a combined (in- and the variability of AtA.
out-patient) psychotherapeutic group Conclusions.– Self-reported disability and time since remission
for the elderly were the strongest predictors of AtA.
V.V. Vodušek Disclosure of interest.– The authors have not supplied a conflict of
University Psychiatric Hospital Ljubljana, Department for interest statement.
Gerontopsychiatry, Ljubljana, Slovenia
Background and aims.– In the final developmental stage of the E-PP0753

human life, man is confronted with many losses in his bodily, per- Intergenerational relationships in old
sonal, social and professional spheres: frailty and transience being age: ambivalent feelings
the negative experiential denominator, isolation and retreat com- S. Von Humboldt* , A. Monteiro, I. Leal
mon maladaptive coping strategies. ISPA-Instituto Universitário, William James Center for Research,
Methods.– Working through these losses can be exacerbated when Lisbon, Portugal
they (i) agglomerate and/or (ii) occur on a background of previously * Corresponding author.
unresolved developmental crises; in such cases a wide variety of
decompensations can occur, depression being the most common. Background and aims.– Intergenerational relationships may be con-
Results.– The gerontopsychiatric inpatient unit can provide a safe flictual or supportive in old age. This study aimed to analyze how
haven for the depressed elderly, the burden of confronting the older adults conceptualize these intergenerational relationships.
agglomerated losses being at least temporarily lifted, in a large part Methods.– In this qualitative study, in-depth interviews were car-
by the inclusion into a larger hospital context of “being taken care ried out with 316 older adults, aged 65-102, from three different
of”, not only from the medical/bodily point of view, but also in the nationalities who lived at home. Verbatim transcripts were exam-
sense of their social and personal inclusion and recognition (as a co- ined.
patient); it does not however prove conducive to the recognition Results.– Data analysis generated six themes representing inter-
and working through the losses that brought them to the hospital generational relationships: affection and reward; interest and
in the first place. integration; grandparent-grandchild interaction quality; privacy
and boundaries definition; provision of support; and obligation of studies have shown that the global quality of life can be prognostic
providing childcare, on two dimensions of ambivalence concerning of survival in these patients.
their intergenerational relationships (supportive and conflictual). The aim of this research was to examine the correlation between
Conclusions.– The empirical findings from this research indicate quality of life and aggression in women suffering from breast can-
how ambivalence in intergenerational relationships is experienced cer.
by older adults and stress the contradictory expectations of older Methods.– The research was conducted at Oncology Clinic, Clini-
adults with grandchildren. cal Center Nis. Patients with a previous diagnosis of breast cancer,
Disclosure of interest.– The authors have not supplied a conflict of who have already undergone a surgical treatment and were on
interest statement. adjuvant therapy, were included in the study. Patients were given
following questionnaires: the Buss–Perry Aggression Question-
naire, 15-item Flanagan’s Quality of Life Scale (QOLS) and General
E-PP0754 socio-demographic questionnaire. We used descriptive and corre-
Can group cognitive training increase lation analysis of the data.
the self-perceived quality of life in the Results.– The group consisted of 95 participants who were diag-
elderly group? nosed with breast cancer. Total average aggression score was
R. Wallner1* , A. Senczyszyn1 , D. Szczesniak1 , B. Tarnowska2 , K. 55.68 ± 13.546. The highest average score was on verbal aggres-
Urbanska1 , J. Rymaszewska1 sion sub-scale – 2.33 ± 0.689, and the lowest average score was on
1 Wroclaw Medical University, Department of Psychiatry, Poland, sub-scale of physical aggression – 1.41 ± 0.332. We found a statis-
Wroclaw, Poland; 2 Silesian Public Library, Stowarzyszenie tically significant negative correlation of quality of life and physical
˛
Organizacji Trenerów Pozarzadowych STO, Wroclaw, Poland aggression (p = 0.022).
* Corresponding author. Conclusions.– Our results show a significant negative correlation
between the quality of life and physical aggression in women suf-
Background and aims.– Quality of life (QoL) as a complex construct fering from breast cancer.
encompassing social, psychological, physical domains is consid- Disclosure of interest.– The authors have not supplied a conflict of
ered to be a primary goal of treatment of possible disabilities interest statement.
(cognitive, emotional, behavioral) in seniors. This goal is achiev-
able through pharmacological and non-pharmacological methods,
including multidimensional computer-based cognitive trainings. E-PP0756
The aim of this study was to evaluate the effects of computer-based Cancer risk and screening
®
Cognitive Training (CT) “Academy of Mind on QoL of the elderly. participation in patients with severe
Methods.– Of the 54 seniors (age >65) included in study, 40 finished
the CT (F/M:30/10; age: 72.4 ± SD = 7.3; mean MoCA = 23.6). CT
mental disorders
R. Barranha1* , B. Melo2 , H. Costa Pinto1
lasted 9 weeks including one 90 minutes’ session per week, accom- 1 Centro Hospitalar do Tâmega e Sousa, Department of Psychiatry and
panied by a corresponding psychoeducational part (e.g. individual
Mental Health, Penafiel, Portugal; 2 Centro Hospitalar Tondela-Viseu,
computer tasks, group games focusing on specific cognitive func-
Department of Psychiatry and Mental Health, Viseu, Portugal
tions, training possibilities, compensation strategies), exercises * Corresponding author.
completed by seniors at home. Sessions were led by a professional
trainer. The Dementia Quality of Life Instrument (DQoL, Brod et. Background and aims.– Cancer is a major cause of mortality
al,1999) and neuropsychological tests were performed before and worldwide, and patients with severe mental disorders (such as
after the training. schizophrenia, other non-organic psychotic disorders and bipolar
Results.– The analysis of data sets showed statistically significant disorder) have higher prevalence of cancer risk factors. There-
improvement of general QoL in above 50% (n = 21) of participants as fore, the participation of these patients in national screening
well as within all five subscales of DQoL: positive affect (p = 0.001), programmes is of paramount importance, as a way to ensure early
negative affect (p = 0.008), feeling of belonging (p = 0.021), self- cancer detection and improve treatment outcomes. This presenta-
esteem (p = 0.019), sense of aesthetics (p = 0.033). tion aims to analyse the data from studies reporting the incidence
Conclusions.– The results of the study confirm the positive effect of of cancer in patients with severe mental disorders. Moreover, we
non-pharmacological interventions such as computer-based cog- intend to review the rates of participation in national screening
nitive training on quality of life of seniors and confirm the positive programmes, identify barriers to screening uptake, and point out
effects of non-pharmacological methods on non-specific psycho- interventions to promote uptake.
logical variables. Further research is necessary to determine if level Methods.– We undertook a literature review by searching in
of cognitive deficits differentiate variables of QoL. PubMed articles written in English, without restriction by year of
Disclosure of interest.– The authors have not supplied a conflict of publication. The key terms used were “psychosis”, “schizophrenia”,
interest statement. “severe mental illness”, “cancer” and “screening”.
Results.– Although the mortality attributed to cancer is higher in
patients with severe mental disorders compared to the general
E-PP0755
population, the incidence of the disease is similar in both groups.
Correlation between aggression and In fact, a recent meta-analysis showed decreased incidence risk
quality of life in breast cancer patients rates of colorectal cancer and prostate cancer among patients with
J. Antonijevic* , O. Zikic, J. Kostic, J. Stojanov, I. Binic schizophrenia. This incongruence is in part a consequence of lower
Faculty of Medicine, University of Nis, Department of Psychiatry, Nis, rates of screening, due to specific barriers that we intend to detail.
Serbia The interventions to promote uptake have to be adapted, particu-
larly in relation to staff involvement and integration with primary
care.
Background and aims.– Quality of life is a multidimensional concept
Conclusions.– Behaviour-change interventions are needed to pro-
which refers to all domains of person’s life and health, and can be
mote cancer screening uptake and to reduce health professional
significant for evaluating the quality of health care in patients with
disinterest in screening this population.
chronic diseases. The diagnosis and treatment of breast cancer in
women can have a severe physical and psychological impact on
interest statement.
the patients, which can lead to a psychiatric comorbidity. Previous
E-PP0757 Results.– The average age of the sample was 42,6 years. Sixty-eight
Is schizophrenia a disadvantage for percent of patients lived in urban areas. The majority of our patients
the diagnosis and prognosis of cancer? were housewives. Almost all of the patients interviewed had family
F. Casanovas1* , F.N. Dinamarca2 , A. Pérez Oms2 , M. Calls Samora2 , support. The prevalence of body image disorder was 45%, according
D. García Hernández2 , C. Llimona Sanchez2 , E. Pérez2 , M.C. Poso3 , to BIS. The prevalence of erectile dysfunction was 75%, according
M. Sala3 , E. Sarsaneda4 , I. Ruiz2 to the FSFI. The body image disorder significantly increased the
1 Medical doctor. Resident., Psychiatry, Barcelona, Spain; 2 Institut de prevalence of erectile dysfunction (p < 10−3 ).
Neuropsiquiatria i Adiccions, Hospital del Mar, Psychiatry, Barcelona, Conclusions.– This work raises awareness of the importance of
Spain; 3 Hospital del Mar, Epidemiology, Barcelona, Spain; 4 Hospital addressing sexuality with breast cancer patients given the flagrant
lack of communication between doctors and patients about sexu-
del Mar, Medical Record, Barcelona, Spain
* Corresponding author. ality issues.
Background and aims.– Schizophrenia is a prevalent chronic mental interest statement.
illness that usually determines unhealthy life habits that can lead
to other chronic diseases. The relation between schizophrenia and
cancer is controversial. There are studies that suggest a lower inci- E-PP0759
dence for some types of cancer but a higher standardized mortality. Clinical and genetic factors associated
This could be explained by a delayed diagnosis or a limited access with cognitive function in cancer
to specific treatment among patients with schizophrenia. patients: a cross-sectional study
A comparative retrospective study of patients diagnosed with can- A. Hajj1* , R. Khoury1 , A. Awad2 , T. Nehme2 , B. ElJebbawy2 , F.
cer (with and without schizophrenia) treated in a general hospital ElKarak3 , F. Nasr3 , G. Chahine3 , J. Kattan3 , L. Khabbaz1
is carried out. 1 Saint-Joseph University, Laboratory of Pharmacology, Clinical
Methods.– Sociodemographic and clinical variables of all patients Pharmacy and Quality Control of Drugs, Faculty of Pharmacy, Beirut,
included in the Tumor Registry of the Hospital del Mar between Lebanon; 2 Saint-Joseph University, Faculty of Pharmacy, Beirut,
2000 and 2018 were selected (n = 22.953). Two groups were iden- Lebanon; 3 Hôtel-Dieu de France Hospital, Saint-Joseph University,
tified considering schizophrenia as a comorbidity. Non-parametric Faculty of Medicine, Department of Hemato-Oncology, Beirut,
bivariant analisys was performed. Lebanon
Results.– In our sample, 0,43% of the sample had diagnosis of * Corresponding author.
schizophrenia. The mean age at diagnosis of cancer was 58,14
compared to 65,52 at control group. The proportion of patients Background and aims.– Cancer-related cognitive changes and
who were at Stage-IV of their cancer at diagnosis was 25% among impairment are frequently misdiagnosed despite their negative
patients with schizophrenia compared to 17% at control group impact on patient’s daily functioning and quality of life. They can be
(p < 0,05). Cervical cancer was more frequent (6.5 versus 12.5%) related to different factors including cancer itself, comorbid condi-
in patients with schizophrenia. However, prostate cancer was less tions, treatment and genetic factors. The aim of this study was to
common (12.1 versus 2.5%). assess clinical and genetic factors affecting cognitive function in a
Conclusions.– In this study, a diagnosis of cancer was found at sample of patients with cancer undergoing chemotherapy.
younger ages for patients with schizophrenia. Cancer was diag- Methods.– A cross-sectional study was carried out between
nosed at more advanced stages in this group. As it has been December 2017 and June 2018, using the Functional Assessment
described in previous studies, prostate cancer prevalence was less of Cancer Therapy-Cognitive Function (FACT-Cog), the visual ana-
frequent in schizophrenia group. Further studies are needed in this logue scale for pain and the Hospital Anxiety and Depression Scale
area. -HADS. The study was approved by the hospital ethical committee
Disclosure of interest.– The authors have not supplied a conflict of (Reference:CEHDF1016) and all patients gave their written con-
interest statement. sent. DNA was obtained using a buccal swab (FTA® technology) and
genotyping for different genes (COMT, OPRM1, CRY2, CLOCK) was
performed using the Lightcycler® (Roche).
E-PP0758 Results.– A total of 50 patients were included (70% females).
Breast cancer: impact of body picture Bivariate analyses showed that anxiety and pain were negatively
disorder on sexuality correlated to the cognitive function: the mean perceived cognitive
N. M’hedhbi1 , I. Chaari2* , N. Marrakchi3 , M. Belarbi1 , M. Karoui2 , E. impairment score (CogPCI) decreased with the increase of anxiety
Faten2 , M.F. Mrad2 (p = 0.017) and of pain (p = 0.001). None of the examined genetic
1 Razi Hospital, Psychiatry Department A, Mannouba, Tunisia; 2 Razi polymorphisms was associated with cognition. Pain remained sig-
Hospital, Psychiatry Department G, Mannouba, Tunisia; 3 Salah nificantly associated with the CogPCI scores in the multivariate
Azaiez institute, Outpatient Medical Oncology department, Tunis, analysis (Beta = −0,416; p = 0.002).
Tunisia Conclusions.– These preliminary results confirm the importance
* Corresponding author. of an adequate assessment of different factors affecting cognitive
functioning in cancer patients, particularly pain and other psycho-
Background and aims.– Treatment of breast cancer may induce logical factors (anxiety, depression), as part of a comprehensive
severe repercussions on the female body. This could cause a dis- oncological care plan. Further research is needed in that perspective
tortion of the body image. The aim of this study was to estimate so that an optimal patient outcome can be achieved.
the prevalence of body image disorder and sexual dysfunction in Disclosure of interest.– The authors have not supplied a conflict of
Tunisian women with breast cancer. interest statement.
Methods.– We conducted a descriptive cross-sectional study over
a four-month period from 01/10/2016 to 30/01/2017 at the out-
patient medical oncology department at the Salah Azaiez Institute
in Tunis. One hundred female patients were included, aged of 20
years or older and with histologically confirmed breast cancer, for
a period of six months to one year from the date of diagnosis. Data
collection was done using two scales: Body Image Scale (BIS) and
The Female Sexual Function Index (FSFI).
E-PP0760 and 37 of them were reevaluated. For the evaluation of psychiatric

Prescription pattern of psychotropic comorbidities a number of eight scales were used: Hospital Anx-
drugs in newly diagnosed breast iety and Depression Scale, Quality of Life Questionnaire, Athens
Insomnia Scale, Numeric Rating Scale for Pain, CAGE scale and
cancer patients Fagerstrom test, Global Assessment of Functioning and Montreal
H.C. Hu1* , C.S. Lin2 , Y.C. Hung1 , H.C. Chiu3
1
Cognitive Assessment.
Yuan’s General Hospital, Department of Psychiatry, Kaohsiung,
Results.– As expected, depression and anxiety are underdiagnosed
Taiwan R.O.C.; 2 Kaohsiung Medical University, Department of
among the lot of the study. The quality of life is corelated with
Healthcare Administration and Medical Informatics, Kaohsiung,
intensity of pain, depression and anxiety level. There was a high
Taiwan R.O.C.; 3 Changhua Christian Hospital, Department of
rate of alcohol and nicotine use among these oncological patients,
Education and Epidemiology Research Center, Changhua, Taiwan
although the majority of them stopped the consume after con-
R.O.C.
fronting the diagnosis.
Conclusions.– To sum up, patients from oncology department
Background and aims.– Breast cancer is the most commonly diag- should have access to psychiatric services due to high prevalence of
nosed cancer among women in Taiwan. Many breast cancer this type of disorders. Both the disease and oncological treatment
patients suffered from psychological symptoms. Most research influence the quality of life and can lead to anxiety and depression.
focuses on psychotropic drugs prescription after cancer diagnosis Disclosure of interest.– The authors have not supplied a conflict of
or in cancer survivors. Our aim is to investigate the prescription interest statement.
pattern of psychotropic drugs before and after cancer diagnosis in
newly diagnosed breast cancer patients.
E-PP0762
Methods.– We analyze the secondary database of the 2005 cohort
using the Taiwan National Health Insurance Research Database. Specific characteristics of cognitive
Female patients aged ≥18 years old with newly diagnosed breast functioning in patients with
cancer from 2003 to 2008 were included. The diagnosis of any Hodgkin’s lymphoma: a pilot study
organic psychosis, dementia or other psychiatric disorders were A. Marchenko1 , E. Vinokurova1 , S. Khrushchev1,2* , D. Vybornykh2 ,
excluded. Psychotropic prescription pattern (prescription ≥ once a G. Rupchev1,3 , A. Tkhostov1,4
month) during the one-year period before and after the diagnosis 1 Lomonosov Moscow State University, Psychology Department,
was described. Moscow, Russia; 2 National Research Center for Hematology,
Results.– Total 2,206 patients were included and 54.58% patients Psychiatry and Neurology Department, Moscow, Russia; 3 Mental
have psychotropic drugs prescription. Prescription rate from high Health Research Center, Mental Health Research Center, Moscow,
to low in order to be anxiolytics, sedative-hypnotics, antidepres- Russia; 4 Sechenov First Moscow State Medical University Sechenov
sants, and antipsychotics. As for prescribing trend, it increases from University, Psychology Department, Moscow, Russia
the first month before the diagnosis of cancer, reaches a peak within * Corresponding author.
2 months after diagnosis, and then gradually decreases. In the 12th
month after cancer diagnosis, it is still higher than before diagno- Background and aims.–
sis. Regression analysis showed that old age group, severe medical Introduction.– During the last decades only several research of
comorbidity and chemotherapy group have high probability of psy- neurocognitive impairments in patients with hematological malig-
chotropic drugs prescription. nancies have been presented. Qualitative objective research are
Conclusions.– Psychotropic drugs prescription increases in newly rare, although the importance of assessing cognitive functions
diagnosed breast cancer patients. Anxiolytics are the most com- during and after chemotherapy is crutial for quality of life and
monly prescribed drugs. Clinicians should pay more attention to the therapeutic compliance.
psychological needs of patients before and after cancer diagnosis. Objectives.– The purpose was to determine specific features of cog-
Disclosure of interest.– The authors have not supplied a conflict of nitive sphere in patients with Hodgkin’s lymphoma in order to
interest statement. develop rehabilitation programs.
Methods.– The pilot study included 22 patients with Hodgkin’s
lymphoma (12 women, mean age 30,1 ± 8 years). Cognitive func-
E-PP0761 tioning was evaluated using The Brief Assessment of Cognition
Are there ways to prevent psychiatric in Schizophrenia (BACS), pathopsychological diagnostic methods
of thinking and memory, Rorschach test (the Rorschach Compre-
affections in oncological patients?
hensive System). A qualitative analysis was conducted. Statistical
T.C. Ionescu1* , M. Bran2 , M. Ladea1
1 analysis was performed with SPSS 22.
Alexandru Obregia University Hospital, Psychiatry III, Bucharest,
Results.–
Romania; 2 Coltea Clinical Hospital Bucharest, Department of
Psychiatry, University of Medicine and Pharmacy Carol Davila,
Bucharest, Romania
Background and aims.– Psycho-oncology gives an approach to can-

cer patients and treats the emotional, social and spiritual distress
which accompanies them. Recent research has indicated that not
only illness, but also treatment can lead to severe depression, anx-
iety and distress. This study aims to establish the prevalence of
anxiety and depression, the quality of life, cognitive impairment,
sleep disorders and substance dependence in cancer patients from
a Romanian hospital. It also describes the clinical characteristics of
these patients and examines if different types of cancer have any
influence on the level of psychiatric diagnosis.
Methods.– This is a prospective, longitudinal study that followed
130 patients from the radio-oncology department for three months Figure 1. Percentage of patients with impairments in cognitive
domains.
Results.–The results of the BACS and pathopsychological diagnostic adaptation process develops gradually over a lifetime. Prob-
methods are shown in Figure 1. ably for this reason they pay less attention to consequences,
The results of the Rorschach revealed difficulties in the Cognitive personal control, and treatment control, emotional representa-
Mediation cluster. 31% of patients are prone to perceive events and tions, self-efficacy in rehabilitation. Situation of life-threatening
people incorrectly (XA% < 0.77, WDA% < 0.8). The low perceptual disease, numerous treatment protocols and procedures lead
conventionality was found: 38% of patients gave less than four pop- to high rate of perceived consequences, personal control,
ular responses (P), the average scores of Conventional Form (X+%) treatment control anxiety and self-efficacy in rehabilitation.
and Unusual Form (Xu%) were 0.55 ± 0.1 and 0.27 ± 0.07. (Project Supported By Funding Of Russian Foundation for Basic
Conclusions.– Difficulties with Attention and processing speed Research 18-013-00125 A)
and Abstract thinking are more often observed in patients with Disclosure of interest.– The authors have not supplied a conflict of
Hodgkin’s lymphoma. Cognitive impairments and distortions in interest statement.
perception should be taken into account in patient-physician com-
munication process.
interest statement. E-Poster Presentation: Others - Part I
E-PP0763 E-PP0764
Illness and rehabilitation perceptions Evaluating the effect of a 4-day
in patients with leukemia after bootcamp to support doctors
allogeneic bone marrow returning to training following an
transplantation extended absence
S. Khrushchev1,2* , D. Vybornykh1 , E. Rasskazova2 , A. Tkhostov2,3 , C. Attoe1* , Z. Jabur1 , C. Laws-Chapman2 , C. Tooley1 , W. El Alami2 , J.
O. Koroleva4 , L. Kuzmina4 , A. Koroleva4 , V. Zorenko4 , L. Brooks2 , S. Cross1
1 South London & Maudsley NHS Foundation Trust, Maudsley
Biryukova4 , E. Parovichnikova4
1 National Research Center for Hematology, Psychiatry and Simulation, London, United Kingdom; 2 Guy’s & St Thomas’ NHS
Neurology Department, Moscow, Russia; 2 Lomonosov Moscow State Foundation Trust, Simulation and Interactive Learning Centre,
University, Psychology Department, Moscow, Russia; 3 Sechenov First London, United Kingdom
Moscow State Medical University, Psychology Department, Moscow,
Russia; 4 National Research Center for Hematology, National
Research Center for Hematology, Moscow, Russia Background and aims.– Supporting doctors to return to training fol-
* Corresponding author. lowing a period of absence for medical, family, academic, personal
or other reasons is a priority within the UK National Health Service.
Background and aims.– Allogeneic bone marrow transplantation is Literature demonstrates that skills and confidence can be signif-
a common treatment procedure for some types of leukemia (ALL icantly reduced in doctors taking a 3-month or more break from
and AML). Side effects and distressful symptoms lead to decrease training (GMC, 2012). Returning doctors highlight that bootcamps,
in quality of life of patients and their relatives. Compliance, quality simulation, and intensive training is desirable in supporting return
of treatment and rehabilitation can be mediated and moderated by to work (Health Education England, 2017). This study evaluates the
specific perceptions about illness and rehabilitation. Objectives of impact of a 4-day bootcamp on the skills, confidence, wellbeing, and
the research: to understand illness and rehabilitation perceptions resilience of doctors returning to training.
in patients with leukemia after bone marrow transplantation Methods.– Participants (n = 41) were given validated measures of
Methods.– N = 83 patients with acute leukemia (ALL/AML)after bone human factors skills (Human Factors Skills for Healthcare Instru-
marrow transplantation and hematopoietic stem cell transplan- ment), wellbeing (Warwick-Edinburgh Mental Wellbeing Scale),
tation. Male = 38, female = 45. Control groups: N = 31 (hemophilia and resilience (Brief Resilience Scale), before and after the boot-
A)and N = 20 (chronic kidney disease (G4-G5) male = 9, female = 11). camp. Surveys collected qualitative data from open questions about
All groups patients’ ECOG:1-2.M.a. = 37.2 +− 18.1. SPSS used for participants’ perceived impact on their clinical practice. The boot-
statistical analysis (Compare means, ANOVA Scheffe multiple com- camp blended didactic teaching, group work, simulated scenarios,
parison test). Clinical interview and questionnaires were used and facilitated debriefs to address clinical knowledge and skills,
(illness/treatment and rehabilitation perception, BAI, BDI-II, COPE, human factors skills, self-care, resilience, among other areas.
CABAH, IPQ-R, compliance and disease locus of control) Results.– Statistical analyses found significant improvements to
Results.– Multiple comparisons (Sheffe method)showed significant human factors skills, confidence, wellbeing and non-significant
differences (p < 0.05) in IPQ-R scales between groups (leukemia (L), improvements to resilience. Thematic analyses highlighted self-
chronic kidney disease (CKD), hemophilia A (H)):«Timeline»L/CKD confidence, sharing experiences, feeling supported, and clinical
(p = 0.000), H/CKD (p = 0.024);«Consequences» L/H (p = 0.000), skills are key areas of benefit from the bootcamp.
L/CKD (p = 0,019); «Personal control» L/H (p = 0.000), H/CKD Conclusions.– This study supports the evidence that bootcamps are
(p = 0.001); «Treatment control»L/H (p = 0.000), L/CKD (p = 0,013), effective ways to support doctors returning to training following
H/CKD (p = 0.003); «Identity» L/CKD (p = 0.007); «Emotional a break, improving their wellbeing, skills, and confidence. Such
representations»L/H (p = 0.009); “Psychological attributions” approaches should be used more widely in growing medical work-
L/CKD (p = 0,000), H/CKD (p = 0.006); «Immune attributions» L/H forces. Further research should seek to follow-up returning doctors
(p = 0.016), L/CKD (p = 0,000). «Anxiety in Rehabilitation»:N17- to determine longer term impact on their practice.
N19/D66 (p = 0.011), «Helplessness in rehabilitation»L/D66 Disclosure of interest.– The authors have not supplied a conflict of
(p = 0.000), D66/N17-N19 (p = 0.007), «Self-Efficacy in Rehabil- interest statement.
itation » L/D66 (p = 0.000), L/N17-N19 (p = 0.006), D66/N17-N19
(p = 0.006).
Conclusions.– The main part of presented results can be explained
by clinical features of study groups. Patients with hemophilia
often do not consider it as disease, but as a body peculiarity.
Also hemophilia is inborn disease. As a result, patient overall
E-PP0765 [i] Rifkin A. Some conceptual models in biological psychiatry. Com-

Deep fried nerves, physician burnout prehensive Psychiatry, 1980; 21: page, 350.
A. Bhattacharya Methods.– Survey of the psychiatric literature
Private Practice, AB MD PRO CORP, Oakville, Canada Results.– The stress diathesis model shows most promise
Conclusions.– Breaking the diagnostic logjam necessitates greater
Background and aims.– Everything that works breaks, and physi- attention to diagnostic modelling, and to modelling in general in
cians work very hard from the moment they enter medical school. psychiatry.
As doctors, we arrange our lives around that same career that taxes Disclosure of interest.– The authors have not supplied a conflict of
the balance we need to be healthy. Doctors are often the most interest statement.
stressed of the professions, yet we are expected to be a model of
health, wellness, and optimism. Burnout is the inevitable result of
the imbalance of work and life outside of work. E-PP0767
Methods.– Burnout is a multi-determined conditions caused by Schema modes chemistry
work/life imbalance, poor time management, and perception of E. Chan1* , H.J.R. Tan2
job satisfaction. The student will be able to identify these fac- 1 International Psychology Centre, Psychotherapy, Kuala Lumpur,
tors separately, and dynamically to be able to formulate their new Malaysia; 2 Kajang Hospital, Department of Psychiatry and Mental
knowledge and interpret it correctly. The student will be able to Health, Kajang, Malaysia
apply the learning to recognize burnout and carry out the neces- Background and aims.–
sary adjustments to minimize the deleterious effects of burnout in Background.– There have been various suggestions for couples
their life. attraction based on personality or traits for example, Keirsey, 1984;
Results.– Define burnout and reflect on their own practice to Hendrix, 1988 and Johnson, 2008. The only specific formulation of
assess the presence of this condition in themselves and their peers these proposals was that of Kersey personality theory where Kersey
as distinguishable from other conditions such as depression and (ibid) postulated that the partner with the opposite Kersey person-
addiction. The student will be able evaluate the level of burnout ality type attracted each other due to the need for psychic growth.
they may be experiencing, or recognise the same in a colleague. There was however no data for this proposal. It is postulated in
Furthermore, the student will be able to analyse the effect of their this paper that partners are attracted to each other based on their
burnout on their practice and the transmission of it to their patients. dominant schema modes (Lobestaeel, et. al., 2008). Knowing the
Conclusions.– Share this knowledge with others, especially younger dominant schema modes is important for effective couple therapy
medical graduates who have yet to set up and design their careers (DiFrancesco et al., 2015; Atkinson, 2015).
so that they will minimise the effects of burnout. Aim.– The current paper examines schema mode (Lobestaeel, et. al.,
Disclosure of interest.– The authors have not supplied a conflict of 2008) as the main factor of attraction between couples.
interest statement. Methods.– A group of 50 couples who have been cohabitating for at
least 6 months voluntarily were asked to answer the schema modes
questionnaire (ibid). Their dominant modes were analysed.
E-PP0766 Results.– It was found that there was a consistent pattern of pairing
(Diagnostic) modelling in psychiatry of dominant modes for couples (p < 0.05).
P. Brown Conclusions.– There is a pattern to couple attraction based on their
PierreJanet Centre, Psychiatry, Melbourne, Australia dominant coping modes. This finding is consistent with previ-
ous hypotheses that opposite attracts for the purpose of psychic
Background and aims.– Rifkin quipped vis-à-vis the then (1980) go- growth. The clinical implication of this finding is that one of the
to focus of psychiatric interest, psychopharmacology, that there major contribution to couples conflict is their schema modes dif-
were too many needles and insufficient haystacks. [i] That quasi- ferences which should the main focus of couple therapy ie: schema
dictum can be applied not only to treatment in psychiatry, but couple therapy.
also to diagnosis on the one hand and to service delivery and Disclosure of interest.– The authors have not supplied a conflict of
prevention on the other. Indeed, it can be equally be applied to interest statement.
neuro-psychiatry, neurology and medicine in general. Modelling
in psychiatry is necessary to break the professional logjam. Core
elements vis-à-vis diagnostic models, include: E-PP0768
• Dichotomisation between disparate ontologies: humanistic, reli-
Possibilities for application of fractal
gious and scientific.
• Clarification of relationship of the mind to the brain and psychi- analysis in psychiatry
atry to neurology S. Slatina1 , A. Dzubur Kulenovic2* , H. Sikira1 , E. Smajic Mesevic1 ,
• Epistemology necessarily grounded in inference/induction before M. Muhic1 , E. Ribic1
1 University of Sarajevo Clinical Center, Department of research and
deduction; the latter validates the empirical data generated by
inductive exploration. methodology, Sarajevo, Bosnia - Herzegovina; 2 University of
• Diagnostic models encompassing Sarajevo Clinical Center, Department of Psychiatry, Sarajevo, Bosnia -
a. Diagnostic dimensions/categories related to psycho- Herzegovina
pathophysiology and exogenous (physical and psychological
stressors/endogenous (genotype/epigenotype) causation Background and aims.– In mathematics, fractals are infinitely com-
b. The dimension of the person in the BPS model expanded to plicated abstract objects used to describe and simulate naturally
include pace and time in ontogeny and phylogeny occurring objects. In the past decade, fractal geometry was shown
• Integration of diagnostic models with models of treatment ser-
to be universal tool for analysis and quantification of geomet-
vice delivery and prevention ric complexity of natural objects, including the brain. This can be
• The Stress-psychophysiopathogenesis-diathesis model
observed through CT and MRI scans analyses.
Objectives.– Methods.– Systematic literature review using pre-defined search
1. Delineation of the principles of modelling criteria and two databases.
2. Delineation of the stress-psychophysiopathogenesis-diathesis Results.– FA could have numerous applications in psychiatry. Com-
model parison between fractal dimension (FD) of EEGs of patients with
depression and healthy controls shows that patients with depres-
sion show higher resting FD, and when exposed to music and noise. Background and aims.– HIV infection remains a major global health
Negative emotional bias of depressed patients is showed through priority. It is a source of physical and psychological pain as well
higher complexity increase when exposed to noise than to music. as relational difficulties. Psychiatric disorders (anxiety, depression
FA of mitochondrial DNA (mtDNA) could be used in early diagnosis and law self-esteem) are frequent due to physical pain and social
of Alzheimer’s disease, and can differentiate between changes in stigmatization.
mtDNA caused by physiological aging from those due to AD. MRI The aim of our study is to assess anxiety and depression and explore
of controls and patients with schizophrenia and bipolar disorder the quality of self-esteem of Tunisian patients living with HIV.
shows consistent average FD for all brain structures for controls, Methods.– A descriptive cross-sectional study was conducted about
and consistent differences in patients, indicating change in brain 55 Tunisian patients suffering from HIV infection. We have used a
and structures complexity. semi-structured interview and two scales: the Rosenberg scale to
Conclusions.– FA provides potential for researchers, enabling objec- determine the quality of self-esteem, and the Hospital Anxiety and
tivization and quantification of findings hence lowering possibility Depressive Scale for the assessment of anxiety and depression.
of human error. There are no standardised protocols for image and Results.– The total sample had a mean age of 44 years. The partic-
data analysis, which lowers reproducibility of these studies. Most ipants had been diagnosed with HIV infection until more than 6
of studies include small samples, suggesting the need for large scale years before the interview. According to the classification of the US
meta studies, to confirm sensitivity of these methods. Centers for Disease Control and Prevention, 60% of the participants
Disclosure of interest.– The authors have not supplied a conflict of were in stage A upon enrolment in the study; 21.8%were in stage B
interest statement. and 18.2% in stage C. Anxiety was found in 18.2% of cases. The preva-
lence of depressive symptomatology was 27.3%. Self-esteem was
very law in 29.1%, law in 43.6%, medium in 21.8% and high in 5.5%
E-PP0769 Depressive symptomatology is more frequent in men (p 0.014).
Personality and creativity among Conclusions.– Screening for anxiety and depression and the deter-
un-professional artists: which link? mination of the quality of self-esteem and risk factors allows the
S. Elleuch* , R. Sellami, T. Fourati, A. Chaabouni, I. Feki, J. Masmoudi establishment of prevention and education programs and adapted
Department Psychiatry A, CHU Hedi Chaker, Sfax, Tunisia psychiatric care in multidisciplinary approach.
interest statement.
Background and aims.– Theory and research in personality psychol-
ogy and creativity share an essential commonality: emphasis on the
uniqueness of the individual. The aim of our study was to assess per- E-PP0771
sonality dimensions in a population of un-professional artists and Factors of participation in exercise
to study the link between creativity, affective temperament and therapy during in-patient treatment
different dimensions of personality. K. Friedrich1* , J. Krieger1 , V. Rößner-Ruff1 , M. Wendt2 , I.T.
Methods.– It’s a cross-sectional and analytical study included un- Graef-Calliess3 , R. Brase4 , M. Ziegenbein4
professional artists practicing different arts and randomly recruited 1 Klinikum Wahrendorff, Forschung & Entwicklung, Sehnde,
in different events over a period spread to 6 months. We used a self- Germany; 2 Klinikum Wahrendorff, Sporttherapie, Sehnde, Germany;
administered anonymous questionnaire. Creativity was assessed 3 KRH Psychiatrie Wunstorf, Klinik für Allgemeinpsychiatrie und
using the CAQ self-questionnaire in English. We used the Neo-PI- Psychotherapie, Wunstorf, Germany; 4 Klinikum Wahrendorff,
R questionnaire assessing personality dimensions according to the Allgemeinpsychiatrie, Sehnde, Germany
Big 5 model with 45 items to evaluate personality. Background and aims.–
Results.– 50 un-professional artists were included. Their average Introduction.– An active lifestyle is associated with certain positive
age was 26.9 (gap deviation (GD) 8.61) with a sex-ratio 0.78. 42% physical health outcomes and mental benefits. However, previ-
had visual arts productions and 34% were amateur musicians. Par- ous studies have indicated that people with psychiatric disorders
ticipants had a median of 8 [1–74], at the CAQ test. The highest score tend to fail to meet activity recommendations. Recent research
was that of O dimension (openness, originality) with an average of has shown beneficial effects of physical activity in treatment of
4.05 (GD 0.5) and the lowest was that of N dimension (negative psychiatric disorders. For this reason, questions of practical imple-
emotions, neuroticism and nervousness) (average score 2.85 (GD mentation of exercise therapy interventions in psychiatric settings
0.82). The dimension C (consciousness, stress, control) was posi- are highly relevant for clinical practice to increase patients’ partic-
tively correlated with age (r = 0.367, p = 0.027) and was higher for ipation, reduce obstacles and enhance their motivation.
visual artists than those who practice performance art (p = 0.019). Objectives.– This study examines factors affecting participation and
The higher the scores of the O dimension, the more creative they motivation of patients’ exercise therapy treatments in Wahren-
are (r = 0.380, p = 0.007). dorff clinic. Male and female in-patient and day-clinic patients aged
Conclusions.– Thus these personality dimensions may be regarded between 17 and 67 with a psychiatric diagnosis (ICD 10) will be
as additional resources thanks to which creative processes are effi- studied. They have access to exercise therapy which is provided as
ciently powered up. individual and team sports by sports therapists and physiothera-
Disclosure of interest.– The authors have not supplied a conflict of pists. Patients with eating disorders were excluded.
interest statement. Methods.– A qualitative approach, using structured focus group
interviews with patients and employees, was conducted from July
to September 2018. The patient groups were same-sex as well as
E-PP0770 mixed-sex. One of the mixed-sex groups consists of patients who
Prevalence and correlates of didn’t participate in exercise therapy at all. The employee groups
psychiatric disorders in patients living include physicians, psychologists, nurses, occupational therapists,
with HIV sports therapists and physiotherapist.
R. Feki1* , L. Zouari1 , M. Koubaa2 , S. Omri1 , M. Maalej1 , N. Charfi1 , J. Results.– Intrapersonal, interpersonal, environmental and institu-
Ben Thabet1 , M. Ben Jemaa2 , M. Maalej1 tional factors are analyzed. The first results will be presented.
1 Hopsital Hedi Chaker, Psychiatry C, Sfax, Tunisia; 2 Hopsital Hedi Conclusions.– The results of the study might help to increase
Chaker, Infectious disease, Sfax, Tunisia patients’ participation, reduce obstacles and enhance their moti-
* Corresponding author. vation to participate in exercise therapy in psychiatric in-patient
and day clinical settings.
Disclosure of interest.– The authors have not supplied a conflict of Parents. She developed insidious oral automutilations. She was
interest statement. examined and followed by dermatologists and psychiatrists. No
etiology was retained. She developed few months later movement
disorders. Neurological examination has concluded to choreic mou-
E-PP0772 vements interesting the head and upper limbs, tendon areflexia and
Neuropsychological profile in children cognitive impairement. Blood smear revealed acanthocytes (9%).
with learning difficulties Biological assessment showed a high level of muscular enzymes
D. Galletta1* , A.I. Califano1 , M. D’Amaro2 , S. Celentano3 (CPK = 1000IU/L, LDH = 600IU/L). Cerebral MRI showed an atrophy
1 University of Naples Federico II, Department of Neurosciences and of caudal nuclei. The EMG concluded to a sensitivo-motor axonal
Reproductive and Odontostomatological Sciences, Naples, Italy; 2 neuropathy, predominant in inferior limbs. Genetic assessment for
Sanitary Pole La Filanda Lars, Sanitary Pole La Filanda Lars, Sarno, Huntington disease was negative. We retained the diagnosis of
Italy; 3 Sanitary Pole La Filanda Lars, Sanitary Pole La Filanda Lars, neuroacantocytosis and the treatement was mainly symptomatic
Sarno, Italy (Neuroleptics and vitamins). Evotution and prognosis were poor.
* Corresponding author. Conclusions.– Neuroacanthocytosis is a rare affection with a poly-
morphous clinical expression. We should consider that affection
Background and aims.– Introduction:Learning difficulties are rep- even with isolated inaugural psychiatric signs.
resented by any difficulty encountered by a student during Disclosure of interest.– The authors have not supplied a conflict of
school career. Several studies have focused attention on the interest statement.
neuro-cognitive functions of children with learning difficulties,
underlining the alteration of the following neuropsychological
E-PP0774
functions: executive functions, attention, verbal working mem-
ory, language, speed of processing and inhibition, reading and Mania associated with ginseng: a
writing, verbal Learning and Memory, verbal comprehension, systematic review
visuo-constructive abilities and visuo-conceptual skills (Rucklidge E. Guillot De Mergelina* , A. Pastor Romero
2002, Jakobson 2007 Shahzadi Malhotra et al., 2009;). Hospital Clinico Valencia, Psychiatry, Valencia, Spain
Objectives.– Define and compare, in an Italian language sample, the
neuropsychological profile of children with learning difficulties.
Background and aims.– Ginseng is one of the most widely used
Methods.– Methods: The sample consists of 64 school-age children
herbal medicine and is reported to have a wide range of therapeutic
(ages 8 to 11), of which 37 males and 27 females. Tools used are:
and pharmacological applications, including mood disorders and
Raven 47 and BVN. Cognitive functions investigated were: selective
anxiety treatment. The global ginseng market is estimated to be
visual attention, short term verbal memory, verbal working mem-
worth $2 billion. Several studies analyse the risk-benefit of ginseng
ory, the ability to read and write; the ability to reason or the ability
in terms of mental health.
to analyze, build and integrate a series of concepts
Our objective was to evaluate whether ginseng can induce mania,
Results.– Results: all children showed greater impairment in visual
and if so, to determine if the appearance of this effect could be
selective attention with consequent relapses in the reading area.
related to a pre-existing condition and other patient characteristics.
There were difficulties in the area of executive functions. The short
Methods.– A systematic review was performed based on articles
term verbal memory and the working memory are more conserved.
published in Pubmed, following the PRISMA guidelines and com-
In addition, gender differences were found because the females
bining the use of electronic and manual methods. From 160 articles
achieved better performance in all areas investigated than males.
only 10 met the inclusion criteria for our review.
Conclusions.– Conclusions: In agreement with the international sci-
Results.– In 5 of the cases reported, the average time of ginseng
entific literature it is important to study the neuropsychological
consumption was 35 days prior to the onset of the symptoms.
profile of children with learning difficulties, in order to strengthen
The symptoms occurred at different doses of ginseng. All of them
the deficient areas and prevent school failures and dropouts.
required antipsychotic treatment. In at least four cases, hospital
admission occurred with rapid remission of the symptoms. These
interest statement.
episodes do not seem to be related with psychiatric background.
Conclusions.– No specific data could be obtained about epidemiol-
E-PP0773 ogy and pathogenesis. There are few reported cases in the scientific
literature despite the extended use of ginseng. Using the recom-
Diagnostic challenges of mended doses, ginseng does not seem to pose a risk of mania.
automutilations: a case report Further studies are needed for a better understanding of this phe-
M. Gharmoul1* , L. Ali2 , M. Dhouibi3 , A. Hssine2 , M. Ben hlima2 , S. nomenon.
Ben Amor2 Disclosure of interest.– The authors have not supplied a conflict of
1 Farhat Hached University Hospital, Psychiatry Department,
interest statement.
Msaken, Tunisia; 2 Sahloul University Hospital, Neurology
Department, Sousse, Tunisia; 3 Farhat Hached University Hospital,
Psychiatry Department, Sousse, Tunisia E-PP0775
* Corresponding author. Parental death due to natural death
causes during childhood abbreviates
Background and aims.– Automutilation is a common psychiatric
behavior disorder. However, it could be the revealing sign of a rare the time to a diagnosis of a psychiatric
neurological disease such as neuroacanthocytosis. disorder in the offspring: a follow-up
The aim of this work is to highlight the difficulty dignostique in study
front of automutilations and to show the importance to discuss the M. Haapea1,2,3* , T. Nordström1,3 , S. Räsänen2 , J. Miettunen1,3 , M.
neurological origin. Niemelä1,2
Methods.– our work is about a case of a patient who consulted the 1 University of Oulu, Center for Life Course Health Research, Oulu,
dermatology department and then the psychiatry department for Finland; 2 Oulu University Hospital, Department of Psychiatry, Oulu,
automutilations during the year 2016. Finland; 3 Oulu University Hospital and University of Oulu, Medical
Results.– We report a case of a 39 year-old patient, without previ- Research Center, Oulu, Finland
ous history of neurological disease. She is Born to Consanguineous * Corresponding author.
Background and aims.– Approximately five percent of children face with depression or neurotic spectrum disorders had a lesser degree
a parent’s death before reaching adulthood, which has been shown of self-stigma than the patients with schizophrenia spectrum dis-
to increase the offspring’s risk of poor health outcomes and adverse orders. The severity of the illness significantly correlated with the
social consequences. We aimed to find out whether a parent’s death QoL, self-stigma, and coping strategies.
abbreviates time to a diagnosis of psychiatric disorders in the off- Conclusions.– The investigation confirmed the connection between
spring and to study the effect of the most common death causes on the quality of life, self-stigma, coping strategies, and the severity
this association. of the illness, in outpatients with schizophrenia, depressive, and
Methods.– Data from various national registers on the time and neurotic spectrum disorders. Further longitudinal studyh would be
cause of parents’ deaths and on the time of psychiatric disorder useful to determine the causative relationships of these variables.
diagnoses of the offspring up to 28 years of age were collected Disclosure of interest.– The authors have not supplied a conflict of
for a sample from the Northern Finland Birth Cohort 1986 (422 interest statement.
with parental death before their 18th birthday, and 6,172 matched
controls). We compared the time to diagnoses between those with
and without parental death using Kaplan-Meier and Cox regression E-PP0777
analyses. A non smoking program in the
Results.– Of parental deaths, 334 (79.1%) were due to natural and psychiatric clinic: eradicating tobacco
84 (19.9%) due to unnatural causes. The cohort members with
from the therapeutic space
parental death were given a diagnosis of a psychiatric disorder
J.A. Jaber Filho1* , J. Verissimo Jr.2 , A. Hollanda2 , A. Tomé2 , P.C.
earlier than their controls (10-year survival proportions: 88.6%
Geraldes2
vs. 93.1%, p = 0.001). The corresponding survival proportions were 1 Clínica Jorge Jaber, Saúde Mental, Rio de Janeiro, Brazil; 2 Clínica
88.3% vs. 93.8% (p = 0.001) for natural causes and 89.2% vs. 90.6%
Jorge Jaber, Saúde Mental, Rio de Janeiro, Brasil, Brazil
(p = 0.284) for unnatural causes. * Corresponding author.
Conclusions.– Our findings indicate that parental death due to natu-
ral causes associates increasingly with psychiatric diagnoses of the Background and aims.– Nicotine dependence is a global health prob-
affected offspring. Psychosocial support must be provided as early lem and the second leading cause of death in the world. This article
as when a parent falls ill, especially with those illnesses that are the aims to present the improvement in the technique used by us.
most common causes of death in the population. The results of the implementation of the treatment program in
Disclosure of interest.– The authors have not supplied a conflict of a clinic for treatment of chemical dependence. We also demon-
interest statement. strated that this treatment is possible and safe for patients with
comorbid psychiatric disorders (anxiety, depression, personality
disorders, bipolar disorder and schizophrenia) and drug use dis-
E-PP0776 orders (alcohol, marijuana, cocaine, crack, benzodiazepines with
Self-stigma, coping strategies, severity methamphetamine).
of the disorder and quality of life in Methods.– 122 patients were evaluated at a psychiatric and drug
schizophrenia, depression and treatment clinic in Rio de Janeiro, Brazil. Treatment consisted of
smoking cessation therapy simultaneously with psychiatric treat-
neurotic spectrum disorders -
ment. These patients used pharmacological therapy associated
cross-sectional outpatient study with intensive cognitive-behavioral therapy, occupational therapy,
M. Holubová1,2* , J. Praško2 , M. Ocisková2 , J. Vaněk2 , M. Šlepecký3 , and moderate physical activity. In addition to the associated ther-
M. Zátková3 , K. Látalová2 apy, smoking was limited to three cigarettes daily from the first day
1 Regional Hospital Liberec s.r.o, Department of Psychiatry, Liberec,
of hospitalization. The drug used for the treatment of smoking was
Czech Republic; 2 Faculty of Medicine and Dentistry- Palacky used, as recommended by the manufacturing laboratory. Disorders
University Olomouc- University Hospital Olomouc, Department of for drug use and psychiatric illness were treated as usual.
Psychiatry, Olomouc, Czech Republic; 3 Faculty of Social Science and Results.– Only 82 (67.21%) patients answered the questionnaire
Health Care- Constantine the Philosopher University in Nitra, after 12 months of follow-up. 35 (52.43%) of those who were still
Department of Psychology Sciences, Nitra, Slovak Republic abstinent. The percentage of abstinence in post-discharge patients,
according to previous evaluations (2008–2009) with a 12-month
follow-up, was 51%.
Background and aims.– Much attention has been paid to psycho-
Conclusions.– A high number of patients accepted treatment as well
logical factors influencing characteristics, severity, and course of
as abstinent patients after discharge. Behavioral group therapy and
mental disorders. Some of the factors are quality of life, self-stigma,
physical activities can all be important allies. It is important to
and coping strategies. The objective of our investigation was to
remember that behavioral changes also exert great influence in
examine the interrelations among quality of life (QoL), self-stigma,
maintaining abstinence.
and coping strategies, demographics and severity of the disorder in
neurotic spectrum disorders, schizophrenia, and depressive disor-
interest statement.
ders.
Methods.– A total of 343 clinically stable Czech outpatients with
different mental disorders (109 with schizophrenia spectrum dis- E-PP0778
orders; 81 with depression, and 153 with neurotic spectrum
disorders) were included. The patients were examined by their
Evolution of attitudes of Tunisian
psychiatrists during common psychiatric checkup and completed medical students towards psychiatry
a sociodemographic questionnaire, the Quality of Life Satisfac- over years
tion and the Enjoyment Questionnaire (Q-LES-Q), the Internalized S. Taleb, Y. Zgueb, R. Jomli* , U. Ouali, F. Nacef
Stigma of Mental Illness Scale (ISMI), the Stress Coping Style Ques- Razi hospital, “A” Psychiatric department, La Manouba, Tunisia
tionnaire (SVF-78), and the Clinical Global Impression scale (CGI).
Results.– The study demonstrates that the self-stigma and coping
strategies are significant factors linked to the QoL in all diagnostic Background and aims.– Stigma attached to the mentally ill is a uni-
groups of patients. Patients with schizophrenia spectrum disorders versal phenomenon.
had lower scores in QoL compared to other two groups. The patients
We aim to explore the perceptions of medical students related to E-PP0780

Psychiatry and mental illness, and to compare these perceptions at Internalized stigma, disclosure and
three different time points: 2006, 2013 and 2018.
self- esteem among psychiatric
Methods.– We conducted a cross-sectional descriptive, analytic and
comparative study in 5th year medical students of the Tunis Med-
patients in a general hospital
ical Faculty between April and May 2018. Students responded to a outpatient clinic
questionnaire elaborated for this study to explore the perception of L. Lim1* , J. Goh1 , Y.H. Chan2
1 Singapore General Hospital, Department of Psychiatry, Singapore,
mental illness and psychiatric training. Results are compared with
those of 2006 and 2013 conducted with the same methodology. Singapore; 2 National University Health System- Singapore,
Results.– 30 students were included. Psychiatry was perceived as Biostatistics Unit, Singapore, Singapore
essential for 70%, 60.7% and 60% of students in 2018, 2013, 2006
respectively. It remained a science reserved for specialists for 26.7%
of students in 2018 in comparison with 30% in 2006. The rate
Introduction.– Psychiatric patients often experience internalized
of students who think that psychiatry is an obscure science has
stigma which occurs when persons accept the negative attitudes
significantly decreased from 2006 to 2018. None of the students
of others towards them, then internalise and apply these beliefs to
interviewed in 2018 considered that the mental patient can be rec-
themselves.
ognized by the inspection. This attitude was different from that of
Objectives.– We assess the effects of internalized stigma on illness
2006 (23.3% of students).
disclosure and on self -esteem. We hypothesize that internalized
Conclusions.– Positive attitudes towards psychiatry among medi-
stigma is associated with avoidance of illness and treatment dis-
cal students is to encourage because stigmatizing attitudes among
closure as well as reduced self -esteem, and that these effects are
doctors themselves can result in compromised patient care.
more pronounced among psychiatric patients than controls.
Methods.– Psychiatric patients and controls comprising patients
interest statement.
with medical problems between ages 21 and 65, were randomly
selected by computer to participate in the study, conducted in
E-PP0779 the waiting area of a General Hospital specialist outpatient clinic.
Assuming a moderate difference between psychiatric patients and
The effects of social networking on controls for a power of 80%, a minimum of 65 subjects in each group
adaptation to college life for freshmen would be required to achieve a statistically significant result. The
Y. Lee* , C. sungwon following rating scales were used Rosenberg Self Esteem Scale and
Duksung Women’s University, Clinical Psychology, Seoul, Republic of the Internalized Stigma of Mwental Illness Scale.
Korea Results.– Psychiatric patients demonstrated significantly lower lev-
els of self-esteem than controls. Internalized stigma scores were
highest for singles, and lowest among the married, and older
Background and aims.– Maladjustment in the first year of college
patients. Among psychiatric patients, high levels of internalised
is likely to lead to academic probation and drop-out. Previous
stigma were significantly associated with low levels of self-esteem,
studies have shown that as the adjustment of social relationships
higher levels of experienced discrimination and higher number
decreases, organizational commitment, satisfaction, and mental
of domains in which discrimination was experienced. Those who
health are lowered. Therefore, in this study, we examined the effect
avoided disclosure had significantly higher internalized stigma
of social networking on academic and psychological adaptation
scores than those who self -disclosed.
to college life through the analysis of practical friendship among
Conclusions.– The results confirmed our study hypotheses. Marriage
freshmen.
and older age seemed to confer a protective effect on self -esteem.
Methods.– Data were collected twice from September 2017 to
February 2018. 29 freshmen in a women’s university in Seoul, South
interest statement.
Korea participated in this study. Participants completed below
questionnaires - social networking variables (in and out degree
centrality, closeness centrality, and network size), mental health
factors, and adaptation to college. We collected GPA and absence E-Poster Presentation: Others - Part III
rate after semester. We estimated pairwise correlation among the
social networking variables, the mental health variables and the
college life adjustment variables, and then conducted linear regres- E-PP0781
sion to analyze the effect of social networking on mental health and
adaptation to college life.
Anxiety, depression and burnout in
Results.– The net size, in and out degree centrality, and closeness hospital physicians: comparison
centrality in the beginning of the semester were significant pre- between psychiatrists and
dictors for GPA. The closeness centrality in the beginning of the non-psychiatrists
semester was a predictor for worry and negative effect on the V. Poinsignon1,2,3* , P. Hardy2,3,4 , C. Trichard3,5 , A. Guerin6,7 , A.
absent rate. The in-degree centrality in the close of the semester Pélissolo7,8,9,10 , E. Corruble2,3,4
was a predictor for GPA and alcohol dependence. But it had negative 1 Groupe Hospitalier Paul Guiraud, Pôle Médico-transversal, Villejuif,
influence on the cell phone addiction and absent rate. France; 2 Univ Paris-Sud- Faculté de Médecine, CESP/UMR-S1178-
Conclusions.– In this study, the social networking was associated Equipe “Dépression et Antidépresseurs”- INSERM, Le Kremlin Bicêtre,
with the academic and mental adjustment of freshmen in college. France; 3 Dispositif Territorial de Recherche et de Formation, Dtrf,
Disclosure of interest.– The authors have not supplied a conflict of Paris Sud, France; 4 Hôpital Bicêtre- Hôpitaux Universitaires Paris
interest statement. Sud- Assistance Publique-Hôpitaux de Paris-, Service
Hospitalo-Universitaire de Psychiatrie de Bicêtre, Le Kremlin Bicêtre,
France; 5 Établissement Public de Santé Barthélemy Durand, Secteur
91G05, Étampes, France; 6 Centre hospitalier “Les Murets”, Pôle
clinique 94G05, La Queue-en-Brie, France; 7 Dispositif Territorial de
Recherche et de Formation, Dtrf, Grand Paris-Est, France; 8 Assistance
Publique-Hôpitaux de Paris- Hôpitaux Universitaires Henri
Mondor-Albert Chenevier- Université Paris-Est Créteil, Pôle de nurses reported that they did not use alternatives before employ-
Psychiatrie, Créteil, France; 9 INSERM, U955- Team 15, Créteil, ing restraint practices. Ninety percent of nurses reported using roll
France; 10 Fondation, FondaMental, Créteil, France of gauze as a restraint material. Ninety four percent of the nurses
* Corresponding author. reported that they used four point restraints. A good number of
nurses (68%) reported that the restraint procedure is limited to less
Background and aims.– Physicians are exposed to professional than 2 hours. Only 4% nurses reported receipt of written orders for
burnout (1). For some, psychiatrists are the most vulnerable (2). use of restraints. Eighty percent of the nurses reported that they
Data comparing them to other practitioners are however sparse did not receive any special education or training about restraint
(3). practices.
The aims were to compare anxiety, depression and burnout scores Conclusions.– For a better and ethical mental health nursing care,
among hospital psychiatrists and non-psychiatrists. alternatives to restraint included restraint practice protocol needs
Methods.– In 2017–2018, we conducted an online survey among to be devloped and educated.
physicians working in 21 hospitals or clinics in the south and in Disclosure of interest.– The authors have not supplied a conflict of
the east of Paris. The 61-items questionnaire included the Hospital interest statement.
Anxiety and Depression Scale (HADS) and the Copenhagen Burnout
Inventory (CBI).
Results.– 288 psychiatrists and 414 non-psychiatrists responded E-PP0783
to the survey (response rate = 40.2%). Anxiety score (HADS-A) Prevalence rate of internet addiction
was significantly higher among non-psychiatrists (8.66 vs 7.85;
p = 0.0050), while both personal and interpersonal-related burnout
and its relation with self-esteem,
scores (CBI) were significantly higher in psychiatrists (47.2 vs 43.9; obsession-compulsion, and insomnia
p = 0.0165 and 43.8 vs 38.1; p = 0.0005, respectively). Depression S. Kareemi1 , A. Abdel-Khalek2 , N. Al-Fodery3 , Z. Redha1*
1 Faculty of Social Sciences, Department of Psychology, Kuwait City,
scores (HADS-D) and professional burnout scores (CBI) did not dif-
fer significantly. Kuwait; 2 Alexandria University, Egypt, Psychology, Alexandria,
Conclusions.– Designed to compare psychiatrists to other prac- Egypt; 3 Faculty of Social Sciences, Depatrment of Psychology, Kuwait
titioners, this survey highlights some differences. Both personal City, Kuwait
and interpersonal-related burnout scores were higher in psychia-
trists, while their anxiety scores were lower. Besides, work-related
Background and aims.– The aims of this study were to (a) estimate
burnout scores between psychiatrists and non-psychiatrists did
the prevalence of Internet addiction, (b) explore its relationship
not differ significantly. These results are discussed in consid-
with self-esteem, obsession-compulsion, and insomnia, and (c)
eration of responses bias, socio-demographic and professional
analyze the correlation matrices to explore the main component
characteristics, and psychological risk-factors differences between
(s).
psychiatrists and non-psychiatrists.
Methods.–
1. West CP, Dyrbye LN, Shanafelt TD. Physician burnout: con-
Participants.– A convenience sample of 1021 Kuwait University stu-
tributors, consequences, and solutions. Intern Med 2018; 283:
dents from different specialities was recruited. Their ages ranged
516-529
from 17 to 37.
2. Kumar S. Burnout in psychiatrists. World Psychiatry 2007; 6:
Scales.– The Compulsive Internet Use Scale (CIUS)(Meerker et al.,
186-189
2009)Self-esteem Scale (SES) (Rosenberg, 1989 the Arabic Scale
3. Pejuskovic B, Lecic-Toveski D, Priebe S. Burnout in psychiatrists,
of Obsession-Compulsion (ASOC) (Abdel-Khalek, 1998) the Arabic
general practitioners and surgeons. World Psychiatry 2011; 10:
Scale of Insomnia (ASI) (Abdel-Khalek, 2004).
78
Results.– Table (1) presents the prevalence rates of Internet addic-
tion. The same table shows that men obtained a significantly higher
interest statement.
rate than did their female counterparts in the percentile 90.
Table (2) shows the descriptive statistics of the study measures and
E-PP0782 the t values statistically significant differences between men and
women in the Internet addiction scale, the insomnia (men had the
Restraint practices among psychiatric higher mean scores), and the obsessive-compulsive scale (women
nurses in state mental health care obtained the higher mean scores).
setting Table (3) indicates statistically significant correlation coefficients
B.N. Raveesh1* , S. Renitala2 between Internet addiction, obsessive-compulsive and insomnia,
1 Professor, Psychiatry, Mysore, India; 2 DIMHANS, Psychiatry and this result is relevant to both sexes.
Nursing, Dharwad, India Table (4) Principal components analysis results. The correlation
* Corresponding author. matrices of men and women were analyzed separately using
the principal components analysis, In men, the first factor could
Background and aims.– The main reason to use physical restraints labeled internet addiction and insomnia, and the second factor
in psychiatric wards is to prevent injury to patient and others and could labeled Self-esteem versus obsession. In women, one factor
reduce violent behavior among mentally ill patients. Very few stud- retained and labeled Internet addiction and psychopathology.
ies have been conducted in India about the use of restraints in Conclusions.– Internet addiction is significantly higher among male
psychiatric wards. This research study was conducted to determine compared to female students, and it is significantly related to both
the use of physical restraints and ongoing practices among nurses obsession-compulsion and insomnia in both sexes.
working at psychiatric wards. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– This was a descriptive-cross sectional study done involv- interest statement.
ing 50 psychiatric nurses during June-July 2018. Nurses who agreed
to participate in the study filled out semi-structured self-report
questionnaire prepared by the investigators.
Results.– The average number of patients restrained by each nurse
per month is 9.24. Of the above while physical restraints were
used in 44.63% cases, chemical restraints were used in 64.91%
cases and seclusions were used in 11.22% cases. Eighty percent of
E-PP0784 the concentration of short chain fatty acids and emotional state in
Factors influencing the self-esteem women in the perimenopausal age.
level of the school children with Methods.– To analyze the emotional state Beck’s depression scale
was used. SCFAs concentration by means of gas chromatography
haemophilia A system with a flame ionization detector and silica capillary column
E. Sedova* , E. Shalashugina, Z. Gardanova
with a free fatty acid phase (DB-FFAP, 30 m × 0.53 mm × 0.5 um)
Pirogov Russian National Research Medical University,
was used.
Psychological-Social Faculty, Moscow, Russia
Results.– There were 116 women aged 52.0 ± 4.7 years old enrolled.
The mean points in Beck’s scale was 8.7 ± 9.4 (range 0-38) which
Background and aims.– Issues of developing self-esteem are in the allowed to recognize mild depression in 51(44.0%) women and
focus of interest of various psychological directions. In the context moderately heavy in 4(3.5%). We found that no-depressive women
of clinical psychology it is important to investigate the impact of a had significantly higher concentrations (␮mol/g) of acetic, pro-
chronic disease on the development of the self-esteem. pionic and linear valeric acids (37.41 ± 15.38 vs. 30.81 ± 12.40;
The aim of the current research is studying the impact of various 22.74 ± 11.74 vs. 18.88 ± 7.78; 7.06 ± 3.42 vs. 5.92 ± 1.94, respec-
factors on the self-esteem development of the schoolchildren with tively; p < 0.05) and a tendency toward higher level of all
haemophilia A. SCFAs (112.71 ± 48.45 vs. 97.64 ± 31.23, p = 0.05) branched valeric
Methods.– The research sample consists of 58 schoolchildren in (9.08 ± 4.96 vs. 7.54 ± 3.06; p = 0.05) and lower concentration of
the age from seven to ten years, 28 of them with the diagnosis heptanoic (1.1 ± 1.45 vs. 1.26 ± 1.00, p = 0.05) acids. There were
Haemophilia A and 30 their healthy peers. weak negative correlations between all SCFAs, acetate and propi-
The research methods include: (1) Dembo-Rubinstein Method of onate and Beck’s points (r = −0.183; r = −0.2; r = −0.21, respectively;
Self-Esteem Studying in Prikhozhan’s adapatation (1988); (2) Lip- p < 0.05), and a tendency toward it regarding linear valeric acid
kina’s technique Three Evaluations (1976); (3) Tree Test (Lampen, (r = −0.17; p = 0.07).
in adaptation of Ponomarenko, 1999); (4) Technique Wonder- Conclusions.– SCFAs contribute to human emotional health
land of Feelings (Grabenko et al., 2006); (5) Draw-a-Person Test Disclosure of interest.– The authors have not supplied a conflict of
(Machover, 1946). interest statement.
Results.– The research shows that the children with haemophilia
demonstrate inadequate (either high or low) self-esteem level com-
E-PP0786
paring with their healthy peers. Although we have not found out a
higher level of asthenia and anxiety in the group with haemophilia, Physical activity of people with
it is important to mention that such internal conflicts as rejection mental disorders compared to the
of fight and the fear of the failure can be seen significantly more general population: a systematic
often than in the group of healthy children. review of longitudinal cohort studies
Conclusions.– We would like to emphasize the importance of a fam- S. Suetani1* , B. Stubbs2 , J. McGrath1 , J. Scott1
ily upbringing encouraging the children with a chronic disease to 1 Queensland Centre for Mental Health Research, Psychiatry, Wacol,
make decisions, even smaller ones, by themselves. In some cases Australia; 2 Institute of Psychiatry- Psychology and Neuroscience,
the special psychological intervention program for such children Physiotherapy, London, United Kingdom
should be designed. * Corresponding author.
interest statement. Background and aims.– There has been limited examination of the
bidirectional association between physical activity (PA) and mental
disorders using longitudinal studies. The current review aimed to
E-PP0785 investigate if (a) people with lower PA have an increased risk of
Fecal short chain fatty acids and subsequent mental disorders (compared to those with higher PA);
emotions – is there a link? and (b) people with mental disorders have reduced subsequent PA
K. Skonieczna-Żydecka1* , E. Grochans2 , D. Maciejewska1 , M. (compared to those without mental disorders).
Szkup2 , D. Schneider-Matyka2 , A. Jurczak3 , W. Marlicz4 , I. Methods.– A systematic review of longitudinal studies examining
Łoniewski1 , M. Kaczmarczyk5 , J. Pełka-Wysiecka6 , R. Budawski1 , PA and mental disorders was conducted. Longitudinal studies were
E. Stachowska1 population-based. Mental disorders were defined by International
1 Pomeranian Medical University, Department of Biochemistry and Classification of Diseases or Diagnostic and Statistical Manual of
Human Nutrition, Szczecin, Poland; 2 Pomeranian Medical Mental Disorders. The results were described in a narrative sum-
University, Department of Nursing, Szczecin, Poland; 3 Pomeranian mary.
Medical University, Department of Clinical Nursing, Szczecin, Poland; Results.– Eighteen studies were included and all measured self-
4 Pomeranian Medical University, Department of Gastroenterology, report PA. The majority (sixteen) examined mood disorders and PA.
Szczecin, Poland; 5 Pomeranian Medical University, Department of Three studies found a reduced risk of subsequent mood disorders in
Clinical and Molecular Biochemistry, Szczecin, Poland; 6 Pomeranian those with increased PA, five reported mixed results and five found
Medical University, Department of Psychiatry, Szczecin, Poland no association. One study reported an increased risk of reduced PA
* Corresponding author. in those with prior mood disorders but three other studies examin-
ing the relationship found mixed results. Of four studies examining
Background and aims.– The neural communication within gut-brain anxiety disorders and PA, one study found that those with prior
axis occurs predominantly via the vagus nerve, while biochemical anxiety disorders had reduced subsequent PA. Among three studies
signaling involves hormones, cytokines and bacterial metabolites, examining the reciprocal relationship, no association was identified
among them short chain fatty acids (SCFAs). SCFAs being produced between PA and subsequent anxiety disorders. None of the included
by gut microbiota during fermentation of non-digestible polysac- studies found association between PA and subsequent substance
charides serve as immuno-regulatory compounds. Alteration of use disorders or psychotic disorders.
the intestinal microbiota could therefore influence inflammatory Conclusions.– There is a lack of consistent evidence linking PA to be
state and central nervous systems function encompassing emo- either a risk factor or consequence of mental disorders.
tional state and cognition. The aim was to analyze the link between Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
E-PP0787 non-nuclear family. Female members of the family specially moth-

How to assess an HIV+ mild cognitive ers (45.22%) and wives 33.09%) were the highest group among the
impairment? Results for a pilot survey caregivers of schizophrenia patients.
R. Tempier Conclusions.– Significant proportions of the caregiver of
Montfort hospital, psychiatry, ottawa, Canada schizophrenic patients were the female members of the family.
Other characteristics of the caregivers will help the further
Background and aims.– The prevalence of milder subtypes of Disclosure of interest.– The authors have not supplied a conflict of
cognitive impairment is increasing among HIV-associated neu- interest statement.
rocognitive disorders despite viral suppression by antiretroviral
agents.
E-PP0789
Objectives.– We are reporting on a screening tool for cognitive
impairment and psychopathology on an HIV+ clinical population. New diagnostic avenues regarding
Methods.– A cross sectional feasibility study was conducted among cognitive functioning and central
patients at an HIV/AIDS Clinic in Ottawa, in 2016. HIV+ subjects coherence in high functioning adult
were aged 18–65 years old with undetectable viral load for at males with autism spectrum disorder
least 6 months. A neurocognitive and psychiatric assessment was
(ASD)
used. It consisted of the Montreal Cognitive Assessment (MoCA),
K. Wojciechowska, M. Walecka,˛ A. Wichniak*
The International HIV Dementia Scale (IHDS), the Psychiatric Diag-
Institute of Psychiatry and Neurology, Third Clinic, Day Ward,
nosis Screening Questionnaire (PDSQ) and a home-made opinion
Warsaw, Poland
questionnaire. * Corresponding author.
Results.– We interviewed 30 participants, including 10 women, 18
said that they would be willing to repeat the assessment, 17 found Background and aims.–
it very easy to understand and follow instructions. The mean IHDS Introduction.– Autism Spectrum Disorder (ASD) in adults, especially
global score was 10.5, mean MoCA score was 25.8, mean PDSQ score high functioning ones is often difficult to differentiate. Therefore,
was 43.5. Their mean CD4/CD8 ratio was at 0.9. many adults with neurodevelopmental disorders are misdiagnosed
Conclusions.– There is evidence of the feasibility of this assess- and their neuropsychological difficulties not properly addressed.
ment tool based on participants’ satisfaction rating. Most of the Moreover, frequent comorbid issues make diagnosis a challenging
results were within normal limits for cognitive functioning and psy- prospect.
chopathology. Their immune system was still affected by HIV. This Objectives.– Assessment of a neuropsychological profile of high
study needs to be replicated to determine if HIV+ patients have mild functioning individuals with ASD.
cognitive impairments and genuine psychiatric disorders. Methods.– Participants: 30 males with ASD (as in DSM V) and 30
Disclosure of interest.– The authors have not supplied a conflict of demographically matched controls. Mean age was 30 years. The
interest statement. tests used in the research were: global and local central coherence
tests, D2 Attention Test, Verbal Fluency, Digit symbol substitution
E-PP0788 test and TMT (b).
Results.– Initial results indicate that high-functioning men with ASD
Socio-demographic characteristics of achieve similar score in central coherence tests, but they need sig-
the caregivers of schizophrenia nificantly more time in solving them. The performance on cognitive
patients – a study from tertiary care functioning test has not yielded any conclusive results so far, aside
psychiatric hospital in Bangladesh from the time and accuracy in TMT (B) test. Individuals with ASD
M.M.J. Uddin1* , M.T. Alam2 , H.U. Ahmed3 , F. Alam2 , M.G. Rabbani2 were significantly slower and more accurate in this test than the
1 National Institute of Neurosciences and Hospital, Psychiatry, Dhaka, healthy control.
Bangladesh; 2 National Institute of Mental Health, Psychiatry, Dhaka, Conclusions.– High functioning individuals with ASD show only dis-
Bangladesh; 3 National Institute of Mental Health, Child- Adoloscent crete changes in neuropsychological profile. What stands out is
and Family Psychiatry, Dhaka, Bangladesh their ability to be similarly (or even more) accurate in their per-
* Corresponding author. formance as the control group, yet significantly slower in their
reaction time. This shows especially in the central coherence tasks
Background and aims.– Care giving and care receiving can occur at which require taking situational context into consideration. This
any point in the life course and is typically associated with chronic may indicate that high functioning ASD individuals can compensate
illness or disabilities which result in losses of independence and for cognitive deficits to achieve similar performance as the healthy
functioning. Families are an integral part of the care system for control. One variable that differs them is the time they need to do it.
persons with a chronic mental illness such as schizophrenia. Unfor- Disclosure of interest.– The authors have not supplied a conflict of
tunately only few researches have been conducted in Bangladesh interest statement.
to reveal the characteristics of caregiver and their stressors and
burden.
To assess the characteristics of the caregivers of schizophrenia
patients. E-Poster Presentation: Pain and treatment options
Methods.– This descriptive cross sectional study was done among
the caregivers of schizophrenia patients in outpatient and inpa-
tient department of National Institute of Mental Health (NIMH), E-PP0790
Dhaka, Bangladesh from September 2017 to February 2018. A Sub-psychotomimetic dose of
semi-structured Questionnaire was applied to the caregivers of
ketamine induced analgesia in mice
schizophrenia patients who fulfilled the inclusion criteria. Ethical
S. Atunwa1* , O. Adeyemi2 , A. Owolabi3
issues were maintained accordingly. 1 UNIVERSITY OF ILORIN, PHARMACOLOGY AND TOXICOLOGY,
Results.– Out of 272 caregivers of schizophrenia patients most
ILORIN, Nigeria; 2 Obafemi Awolowo University, Pharmacology,
of them were female (86.03%), housewife (72.43%), of rural area
Ile-Ife, Nigeria; 3 Obafemi Awolowo University, Pharmacology and
(56.25%). Most of the respondents (80.52%) belong to the age range
Medical Therapeutics, Ile-Ife, Nigeria
of 21 to 50 years. Regarding educational status more than 43% * Corresponding author.
completed secondary level. Among the caregivers 81.25% live with
Background and aims.– The roles of N-Methyl-d-Aspartate (NMDA) E-PP0792

receptor in the processing of nociception had led naturally to Randomized clinical trial to compare
renewed clinical interest in ketamine. Low-dose ketamine had
the effectiveness of a mindful
been reported to possess analgesic effect, however the paucity and
inconsistency of such data has called for direct evaluation of this
self-compassion program and a
claim. This study therefore explored the analgesic effect of a sub- behavioral-cognitive intervention to
psychotomimetic dose of ketamine (SPDK), evaluated such effect improve quality of life in chronic pain
on morphine- and diclofenac-induced analgesia and determined patients
the possible neuronal mechanism. M. Torrijos Zarcero1 , Á. Palao Tarrero1 , B. Rodríguez Vega1 , C.
Methods.– Mice weighing between 18–25 g were randomly dis- Rocamora González1 , M. Del Río2 , D.H. Calle1* , L. Nocete1
tributed into two major groups consisting of Group 1 and 2 which 1 Hospital Universitario La Paz, Psychiatry- Clinical Psychology and
were used for the assessment of analgesic effect and determination Mental Health, Madrid, Spain; 2 Universidad Autónoma de Madrid,
of neuronal mechanism of 1 mg/kg ketamine using the hot plate Art Therapy, Madrid, Spain
model; and the formalin-induced pain model respectively. Data * Corresponding author.
were presented as mean ± SEM and analyzed using ANOVA fol-
lowed by post-hoc analysis (Student-Newman–Keuls) and P < 0.05 Background and aims.– Around 10–23% of people suffer from
was set as an accepted level of significance. chronic pain. Chronic pain has a huge impact on patient’s life.
Results.– The SPDK induced significant analgesia in the hot Cognitive-Behavioral therapy (CBT) has been the most common
plate model but showed no analgesic effect rather allodynia in therapy in chronic pain up to now. Other kind of interventions
the formalin-induced pain model. In addition, SPDK potentiated are emerging (Mindfulness interventions) which are, at least, as
morphine-induced and diclofenac-induced analgesia in both the effective as CBT.
hot plate and formalin tests, while naloxone significantly blocked Neff and Germer developed a specific program to improve self-
its analgesic effect at 90 minutes post-administration in the hot compassion, Mindful Self-Compassion (MSC), that is useful in a
plate test. variety of clinical problems.
Conclusions.– This study showed that SPDK induced analgesia more The aim of this study is to compare the effectiveness of MSC pro-
effectively in the acute pain model but otherwise in the chronic pain gram and CBT program to improve Quality of Life and Self-Care in
model. It also potentiated both morphine and diclofenac-induced chronic pain.
analgesia possibly mediated through modulation of opioidergic Methods.– We conducted a RCT with 2 arms of treatments in
pathway in mice. a chronic pain patients sample of Hospital Unviersitario La Paz,
Disclosure of interest.– The authors have not supplied a conflict of Madrid. N = 160. Group interventions, 8 sessions, weekly. We
interest statement. collected data of anxiety, depression, catastrophizing, pain inter-
ference self-compassion, and quality of life. These outcomes were
measured at the beggining and at the end of the intervention
E-PP0791 through clinical interview, HADS, SCS, BPI, CPAQ, PCS and SF-36.
Chronic pain and traumatic life events Results.– We are still collecting and analizying data.
H. Maatallah, R. Damak, I. Berrahal* , N. Ghazouani, W. Cherif, M. Preliminary results.– It seems that MSC is, at least, as effective as CBT
Cheour to improve some aspects of quality of life of chronic pain patients;
Razi Hospital, Psy E, Tunis, Tunisia also as effective as CBT to reduce anxiety and depression, and more
* Corresponding author. effective than CBT to improve self-compassion.
Conclusions.– These results are promising in order to find effective
Background and aims.– Chronic pain is sometimes the symbolic interventions to this prevalent clinical problem.
translation of another suffering locked in the story of life. It finds its Forward, we are collecting data of results in a 6 months follow-up,
energy in the memory of the body. It remains inscribed in a fold of because it is important to find interventions capables of maintain-
the unconscious and then revives in particular circumstances. The ing results across time.
pain then absorbs a suffering of life. Disclosure of interest.– The authors have not supplied a conflict of
Objectives.– To study the relationship between traumatic life interest statement.
events in childhood and the development of chronic pain in adult-
hood.
Methods.– A longitudinal prospective and evaluative study that took E-PP0793
place at the Pain Treatment Center in Tunis from January 2nd to Fatigue and neurological disability in
April 30th, 2018. Our study looked at the patients followed for
multiple sclerosis
chronic pain with evaluation of the traumatic events to childhood
M. Chakroun* , S. Sakka, O. Hdiji, N. Farhat, H. Haj Kacem, M.
by the scale: Childhood Trauma Questionnaire (self-questionnaire).
Dammak, C. Mhiri
Results.– Ninety patients were retained with a predominantly
Habib Bourguiba university hospital, department of neurology, Sfax,
female sex ratio 3F/1H. The average age was 45 ± 3 years and 70%
Tunisia
of the average socio-economic level Patients were followed for: * Corresponding author.
Headache 30%, fibromyalgia 30%, psychalgia 20% lumbosciatalgia
10% and migraine 10%. The traumatic events were: child abuse Background and aims.– Fatigue is one of the most frequent symp-
80% (p = 0.002), sexual abuse 60% (p = 0.003), family conflict 40% toms in patients with multiple sclerosis (MS) and it is difficult to
(p = 0.05), financial hardship 30% and death of father or child mother clarify the nature of this symptom and manage it.
20%. Aims.– To evaluate the prevalence of fatigue syndrome in patients
Conclusions.– The impact of traumatic life events and the confronta- with MS and its correlated factors.
tion with stressful situations in the installation of chronic pain is Methods.– A cross-sectional and analytical study was carried out on
clear from our study. Hence the psychological evaluation is indis- 31 patients with MS, followed up in the neurology department of
pensable in the management of chronic painful patients by listening Habib Bourguiba hospital, Sfax, Tunisia. Demographic data, dura-
and understanding their life trajectory. tion of the disease and the disease course were extracted from
Disclosure of interest.– The authors have not supplied a conflict of patients’ medical files. We evaluated the severity of fatigue symp-
interest statement. toms by the Fatigue Severity Scale (FSS) anxiety and depression by
the Hospital Anxiety and Depression Scale (HADS) and the level of E-PP0795
disability by the Expanded Disability Status Scale (EDSS). Pharmacological and non
Results.– The average age was 34, 19 ± 10 years old with an aver-
pharmacological strategies in
age age at the onset of the disease 25, 06 ± 5.7 years. Relapsing
remitting MS occurred in 80, 6% of cases. The mean EDSS score was
fibromyalgia - A review
3.8 ± 2.6. The prevalence of the fatigue syndrome was 61.3% and C. Leite Rodrigues* , T. Cavaco, J. Rema, R. Santos, E. Fernandes, L.
the mean FSS score was 36 ± 16. Castanheira, E. Reis, M.J. Gonçalves
Fatigue syndrome was significantly correlated to an EDSS score Centro Hospitalar Lisboa Norte - Hospital de Santa Maria,
≥5 (p = 0.002), poor adherence to the treatment (p = 0.012), anxiety Neurosciences Department - Psychiatry and Mental Health, Lisbon,
(p = 0.001), anxiolytic use (p = 0.024) and depression (p = 0.000). Portugal
Conclusions.– This study suggests that fatigue in MS patients can
be the result of depression, anxiety or the level of disability. More Background and aims.– Fibromyalgia is a chronic pain condition
studies in different settings are needed to define fatigue in large presented in at least 2% of the population. Fibromyalgia is char-
population of MS patients and its relation with the disease activity. acterized by widespread pain with similarities to neuropathic pain
Disclosure of interest.– The authors have not supplied a conflict of and is often accompanied by fatigue, sleep compromise, memory
interest statement. impairment, irritable bowel syndrome and mood disorders. The
diagnosis of fibromyalgia should not be an exclusion diagnosis and
often appears in patients with other conditions. No clear patho-
E-PP0794
physiology mechanism has been established in this condition but
The need to improve detection and an abnormality in central pain processing is suggested by evidence.
treatment of physical pain of This condition is responsible for a great decrease in quality of life
homeless people with schizophrenia of patients.
and bipolar disorders. Results from The aim is to do a review of management strategies.
Methods.– A literature review was conducted using the PubMed
the French housing first study search database.
G. Fond1* , A. tinland1 , L. Boyer1 , P. Auquier1 , C. French Housing
Results.– Successful management of this condition should blend
First Group2
1 Aix-Marseille Univ- School of medicine - La Timone Medical education, patient support, physical therapy, exercise, nutrition,
cognitive behavioral therapy and pharmacological therapy. Patient
Campus, EA 3279: CEReSS - Health Service Research and Quality of
self-handling is of extreme importance in aiming for a good man-
Life Center, Marseille, France; 2 Aix-Marseille Univ- School of
agement. Pharmacological therapies with high quality evidence
medicine - La Timone Medical Campus, Ceress, Marseille, France
* Corresponding author. include triciclics, serotonin norepinephrine reuptake inhibitors,
and gabapentinoids. More controversial is the use of various opi-
Background and aims.– The aim of this study was to investigate oids, dopamine agonists and cannabinoids.
the prevalence and associated factors of physical pain in a large Conclusions.– Fibromyalgia is a complex condition that requires a
multicenter sample of Homeless Schizophrenia and Bipolar (HSB) multidisciplinary approach from clinicians. Further evidence-based
patients. knowledge is needed to better comprehend the mechanisms of
Methods.– This multicenter study was conducted in 4 French cities: this condition as well as to give more and better pharmacological
Lille, Marseille, Paris and Toulouse. Pain was measured by EQ5D- options in the treatment of this patients and improve their quality
3L questionnaire with no specified period or location. In addition, of life.
sociodemographic information, duration of homelessness, illness Disclosure of interest.– The authors have not supplied a conflict of
severity using the Modified Colorado Symptom Index (MCSI) and interest statement.
drug information were collected.
Results.– Overall, 655 HSB patients, mean age 38.8 years and
E-PP0796
82.6% men were included, 448 (68.9%) were diagnosed with
schizophrenia and 202 (31.1%) with bipolar disorder. More than Methadone used in the management
half patients (N = 337, 51.5%) reported moderate to extreme phys- of cancer pain
ical pain while only 2.7% were administered analgesic drugs. T. López-Arteaga1* , P. Padilla-Romero2 , C. Romero-Martín3
In the multivariate analysis, self-reported moderate to extreme 1 Psychiatrist, Department of Psychiatry- Hospital Ntra. Sra. del
physical pain was associated with antidepressant consumption Prado, Talavera de la Reina TO- C.P. 45600, Spain; 2 Hospital Ntra.
(adjusted odd ratio aOR = 2.56 [1.25;5.26], p = 0.01), female gender Sra. del Prado, Psychiatry, Talavera de la Reina, Spain; 3 Hospital
(aOR = 1.72 [1.03;2.86], p = 0.04), bipolar disorders (vs. schizophre- Ntra. Sra. del Prado, Hospital Pharmacy, Talavera de la Reina, Spain
nia) (aOR = 1.81 [1.19;2.77], p = 0.006), older age (aOR = 1.03 * Corresponding author.
[1.01;1.05], p = 0.01), with higher MCSI psychotic score (a0R = 1.04

[1.01;1.06], p = 0.002), independently of the number of days in the Background and aims.–
street during the last 180 days, MCSI depression score, alcohol and Introduction.– Pain is a common symptom with cancer and opi-
substance use disorders, psychotropic drugs and analgesic treat- oid (morphine-like) drugs are commonly used to treat moderate or
ments. No association with education level, antipsychotics, mood severe pain. Methadone is a treatment option in oncological pain,
stabilizers, anxiolytic, hypnotic or medication adherence was found allowing lower opioid rotations.
(all p > 0.05). Objetives.– we describe the rotation of transdermal and inhaled
Conclusions.– Physical pain was highly reported in homeless fentanyl to methadone in patient with opioid misuse and cancer
patients with severe mental illness with insufficient care. Physical pain.
pain should be systematically explored and treated in this popu- Methods.– Observational study of a 57-year-old male patient diag-
lation. Bipolar disorders, antidepressant consumption and female nosed with esophageal carcinoma, in treatment with fentanyl in
gender may be targeted in priority. palliative care unit (PCU). The department of psychiatry made an
Disclosure of interest.– The authors have not supplied a conflict of assessment of the patient and the use of opioids that he made. He
interest statement. was admitted to the hospital to make methadone rotation.
Results.– Admission diagnosis was opioid-induced hyperalgesia
and misuse. His usual dose of opioids was: transdermal fentanyl
100 mcg/day and inhaled fentanyl 100mcg rescue. Daily dose was Background and aims.– Ketamine is a non-competitive NMDA recep-
3,076 morphine miligrams equivalents (MME) for last 6 months. tor antagonist. Magnesium is an endogenous non-competitive
Equivalence was performed with methadone dose using a conver- NMDA antagonist that causes anion channel blockade in a dose-
sion factor below 10 percent of the daily dose MME. The patient was dependent manner. Because ketamine and magnesium block
treated with methadone 160 mg delivered every 12 hours. No opi- NMDA receptor activation by distinct mechanisms of action, we
oid withdrawal syndrome was sustained during rotation, no rescue hypothesized that in a model of acute and inflammatory pain in
was required for pain or craving was observed. rats the combination of ketamine and magnesium might be more
Conclusions.– Patients with cancer pain are not exempt from devel- effective than ketamine alone.
oping opioid misuse/abuse during treatment. Methadone should Methods.– Antinociceptive activity was assessed by the tail immer-
be taken into account as the first line in patients in PCU, but nev- sion test and formalin test in male Wistar rats (200–250 g).
ertheless, it is underused in our environment, may be for stigma Results.– Ketamine and magnesium sulfate given separately did not
associated. have any effect in the tail immersion test in rats. However, signif-
Disclosure of interest.– The authors have not supplied a conflict of icant antinociception (synergistic interaction) was revealed at the
interest statement. following doses of ketamine: magnesium sulphate of 5:5 mg/kg,
2.5:5 mg/kg and 10:5 mg/kg. Combination ketamine-magnesium
sulphate reduced nocifensive behavior in the second phase of
E-PP0797 the formalin test in rats. When ketamine was applied after
Depression and anxiety spectrum magnesium sulfate, the log dose-response curves for the effects
disorders in patients with myofascial of ketamine and the magnesium sulfate-ketamine combination
revealed antagonistic interaction, and about 1.6 (CL 1.2–2.4) fold
facial pain syndrome
increment in ketamine dosage. A low dose of magnesium sulfate
I. Malenkova1* , L. Medvedeva1 , O. Zagorulko1 , G. Shevtsova2
1 (5 mg/kg, subcutaneously) administered after ketamine increased
National Research Centre of Surgery, Pain Department, Moscow,
the antinociceptive effect of ketamine by a factor of only 1.2 (CL
Russia; 2 First Moscow State Medical University, Department of
0.95–1.38), indicating an additive interaction. There was a 1.8-fold
Nervous Diseases and Neurosurgery, Moscow, Russia
* Corresponding author. reduction in dosage of ketamine when ketamine was administered
before magnesium sulfate.
Background and aims.– According to the literature, the presence of Conclusions.– Whether there will be an additive or antagonis-
anxiety-depressive disorders in patients with chronic pain varies tic antinociceptive interaction between ketamine and magnesium
between 10–100%. depends on the order of drug administration.
Objective is to evaluate the severity of anxiety and depression in Disclosure of interest.– The authors have not supplied a conflict of
patients with chronic facial myofascial pain syndrome (FMPS). interest statement.
Methods.– Prospective randomized study included 20 healthy
subjects (control group) and 40 patients with FMPS: 20 with tem-
poromandibular joint dysfunction syndrome (TJDS) and 20 without E-PP0799
TJDS. The diagnosis met International Classification of Headache Treatment of myofascial pain
Disorders criteria 2018 (ICHD-3). Depression or anxiety, evaluated syndrome which arose as a result of
with Hospital Anxiety and Depression Scale, was considered if the psychotraumatic factors by methods
score was ≥10. The pain severity was assessed using a Visual Analog
of reflexotherapy
Scale (VAS)
Y. Sirytsyna* , U. But-Husaim, A. Yarosh
Results.– The mean age of the patients in the control group was
Grodno State Medical University, Department of Medical
33.4 ± 7.2 years, in patients with TJDS and without TJDS- 36.8 ± 7.9
Rehabilitation, Grodno, Belarus
and 29.5 ± 4.8 years, respectively. The pain intensity in both groups * Corresponding author.
was 4.9 ± 0.7 and 6.8 ± 0.9 VAS points, respectively. HADS points
for anxiety and depression subscales in the control group were Background and aims.– We developed the set of rehabilitation’s
3.3 ± 0.4 and 1.9 ± 0.5, whereas these values were significantly methods for the patients with myofascial pain syndrome (MFPS),
higher in groups with and without TJDS (14.2 ± 1.5 and 15.9 ± 2.1, which arose as a result of the psychotraumatic stress factor. The
p = 0.04-for the anxiety subscale,14.8 ± 2.0 and 13.1 ± 1.8, p = 0.03 - methods we used included: classical acupuncture, surface reflex-
on the subscale of depression). At the same time, the anxiety was ology, thermo-acupuncture and auriculopuncture.
higher in the group without TJDS, while depression - with TJDS Aims.– Increasing the effectiveness of MFPS patient’s treatment:
symptoms. Higher pain descriptors were associated with the high- reduction of the expression of muscle-tonic manifestations and
est rates of depressive disorders in groups with TJDS (p = 0.02) and pain, improvement of the patient’s mental state, reduction of drug
without TJDS (p = 0.04). burden and treatment time, and improvement of patients’ quality
Conclusions.– FMPS is accompanied by severe comorbid disorders, of life.
such as anxiety and depression. Methods.– 17 patients with MFPS were divided into control 1 (10
Disclosure of interest.– The authors have not supplied a conflict of patients) and clinical 2 (7 patients) groups. All patients received a
interest statement. course of psychotherapy. Patients of group 2 additionally received
proposed methods of reflexotherapy.
Evaluations Methods.– Visual analog scale (VAS), Spielberger-Hanin
E-PP0798 anxiety scale.
Old-new drugs ketamine and Results.– According to the results of the VAS analysis, patients of the
magnesium in the pharmacotherapy 2nd group noted a decrease in the intensity of pain after the course
of pain of therapy on average by 45–50%, as well as a decrease in the level
K. Savic Vujovic* , S. Vuckovic, N. Divac, R. Stojanovic, B. Medic, D. of anxiety on a scale of 35 points and lower. Also their mood was
Srebro, M. Prostran improved and sleep normalized. All differences were statistically
Faculty of Medicine- University of Belgrade, Department of significant.
pharmacology- clinical pharmacology and toxicology, Belgrade, Conclusions.– Using of reflexotherapy in the complex treatment of
Serbia patients suffering from MFPS due to psychotraumatic stress factor
* Corresponding author. increases the effectiveness of therapeutic measures, improves the
mental state of the patient, reduces the severity of the muscular- with a sociodemographic questionnaire and the 26-item version of
tonic manifestations, which is reflected in statistically significant the Levensons Self Report Psychopathy Scale that measures “pri-
improvement in indices, compared with the use of conventional mary” psychopathy (selfish, insensible, and manipulative style),
methods, and also positively affects the quality of life of patients. and “secondary” psychopathy (impulsivity and self-defeating
Disclosure of interest.– The authors have not supplied a conflict of style). We computed cut-offs within the population using the dis-
interest statement. tribution of continuous scores (median value) for the primary and
secondary psychopathy.
Results.– The prevalence of primary psychopathy was 39.6% and of
E-PP0800 secondary psychopathy was 49.8%. The primary psychopathy was
Perceptions of weight control among more prevalent in males (56.4%; c2 = 43.46, p < .001; f = 0.41), with
older adults with knee osteoarthritis ages between 36–64 years (44.6%; c2 = 22.152, p < .001, f = 0.30), and
Y.F. Tsai with no-partner (61.4%; c2 = 8.89, p < .01; f = 0.19). The secondary
Chang Gung University, School of Nursing, Tao-Yuan, Taiwan R.O.C. psychopathy was more prevalent in females (59.1%; c2 = 8.12,
* Corresponding author. p < .01; f = 0.18), with no significative associations with other
sociodemographic variables.
Background and aims.– Knee osteoarthritis (OA) affects mostly older Conclusions.– Our preliminary findings indicate that psychopathic
adults. The primary risk factor for knee OA is obesity. Knee OA sig- traits prevalence is high in the general Portuguese population.
nificantly affects daily activities and causes joint pain. However, We found differences between categories of sociodemographic
few studies have explored weight control in this group. The aims variables in the expression of psychopathic traits; sex differences
of this study were to understand weight-control strategies, facil- follow previous research, but other differences raise questions to
itators of and barriers toward weight control among older adults future investigation.
with knee OA who refused total knee arthroplasty (TKA). Disclosure of interest.– The authors have not supplied a conflict of
Methods.– Older outpatients (N = 120) were recruited from the interest statement.
orthopedic clinics of three hospitals in northern Taiwan. Data were
collected through individual in-depth interviews using a semi-
structured interview guide and analyzed using thematic analysis E-PP0802
and ATLAS.ti, version WIN 7.0. Swedish universities scales of
Results.– Among participants, only 25% had body weight in the personality: relation to other
normal range and 58.3% expressed they were controlling their
personality constructs
weight. Their most common weight control strategies were to
T. Fagerberg1* , E. Söderman1 , J.P. Gustavsson2 , I. Agartz1 , E.G.
decrease the amount of food (98.6%) and to maintain daily activities
Jönsson1
(22.9%). Common facilitators of their weight control were desir- 1 Karolinska Institutet, Human brain informatics HUBIN- Department
ing good health (37.5%), wanting to decrease knee load (30.8%),
of Clinical Neurosience- Psychiatry section- Karolinska institutet and
perceiving that they had gained weight (28.3%), wanting to look
Hospital- Stockholm- Sweden, Stockholm, Sweden; 2 Karolinska
good (9.2%), and advice from healthcare providers (7.5%). Com-
Institutet, Division of Psychology- Department of Clinical
mon barriers to weight control were perceiving that dietary control
Neuroscience- Karolinska Institutet- Stockholm- Sweden, Stockholm,
was challenging (19.2%), not overweight and not needing to con-
Sweden
trol weight (18.3%), wanting to eat natural and not feeling the * Corresponding author.
need to control weight (12.5%), and had tried before but in
vain (5%). Background and aims.– Different personality inventories are used to
Conclusions.– Our findings provide information for healthcare mapping personality traits. Swedish universities Scales of Personal-
providers to understand how weight control is perceived by older ity (SSP) is a 91-item self-rated questionnaire developed from the
adults with knee OA and serve as a reference for developing weight- Karolinska Scales of Personality (KSP) and is available to use free
control programs. of charge. Few studies have investigated relationship between SSP
and other personality constructs.
The aim is to investigate correlations between SSP scales and scales
of the following personality constructs: KSP, revised Chapman
E-Poster Presentation: Personality and scales, Structural Clinical Interview for DSM-III-R axis II screening
Personality Disorders - Part I questionnaire (SCID-II screen), Schizotype, Impulsive and Border-
line scales (SKIB-79), revised NEO personality inventory (NEO-PI-R)
and Health-Relevant 5-factor Personality inventory (HP5i).
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Healthy individuals (n = 619) drawn from a population
interest statement. register, recruited among students or hospital staff members, or
non-psychotic siblings and parents of patients with psychotic dis-
order completed self-report personality questionnaires including
E-PP0801 SSP and at least one more personality inventory. Correlations
Prevalence of psychopathic traits in a where calculated between the 13 different SSP subscales and
sample of the Portuguese population scales/subscales in KSP, Chapman, SCID-II screen, SKIB-79, NEO-
H. Espírito-Santo* , C. Madeira-Sério, C. Duarte, L. Lemos PI-R and HP5i.
Instituto Superior Miguel Torga, Psychology, Coimbra, Portugal Results.– The SSP scales were generally highly correlated with the
* Corresponding author. corresponding KSP scales. Strong correlations between SSP scales
and scales of the other constructs were sparse, although weaker
Background and aims.– Psychopathic traits can be found among correlations were common. SSP neuroticism-related scales corre-
individuals from the general population, but little is known in the lated to NEO Neuroticism (r = 0.80), SSP extraversion-related scales
Portuguese population. This study aims to examine the distribu- to NEO Extraversion (r = 0.63), and SSP aggressiveness-related
tion of psychopathic traits in a sample of the Portuguese population scales to NEO Agreeableness (r = −0.56).
using an internet survey of members of the general population. Conclusions.– SSP is useful as a personality construct when measure
Methods.– 255 participants with ages between 18–77 years old, personality traits related to temperament-like features. The differ-
mean age 33.98 (SD = 14.01), 172 females and 83 males, assessed ent personality inventories are not completely comparable to each
other. Instead, they measure personality aspects in partly different Methods.– A sample of 516 adolescents (52.7% females) from the
ways. two high schools of Marchena (a town in the Province of Seville in
Disclosure of interest.– The authors have not supplied a conflict of Andalusia, Spain) was enrolled. Participants’ age ranged from 14 to
interest statement. 19 years (mean age: 16.15; SD: 1.23). The MAAS-C was adapted to
Spanish by using a forward and back translation process, under the
guidance of the authors of the original version of the MAAS-C. Also,
E-PP0803 the final Spanish adaptation of the scale was pilot tested to check if
Ambiguity and borderline personality the items were correctly understood and to identify any difficulties
disorder: the detection of irony in answering them. To assess internal consistency reliability of the
A. Felsenheimer1* , C. Kieckhäfer2 , A.M. Rapp1 MAAS-C-S, alpha coefficient and mean inter-item correlation (MIC)
1 Universitätsklinik Tübingen, Klinik für Psychiatrie und were computed.
Psychotherapie, Tübingen, Germany; 2 LVR Kliniken Düsseldorf, Results.– The values of the reliability indexes computed were the
Psychiatrie, Düsseldorf, Germany following: Cronbach’s alpha = 0.86 and MIC = 0.31, within the good
* Corresponding author. and optimal range, respectively.
Conclusions.– The MAAS-C-S is a reliable measure to assess uni-
Background and aims.– Being ambiguous at its very core, irony con- dimensionally trait mindfulness in samples of adolescents. The
stitutes a prime example where the natural coupling of intention MAAS-C-S is an easier version to avoid possible understanding dif-
and language is split. Although excessively studied in schizophrenia ficulties of the items in youths.
or autism, there are no experimental studies on irony comprehen- Disclosure of interest.– The authors have not supplied a conflict of
sion in borderline personality disorder (BDP) patients available. interest statement.
However, in some parts the psychopathology of BPD is likewise
shaped by diverging mentalizing and empathy skills. Still, studies
are inconsistent on both, presumably because they manifest them- E-PP0805
selves in rather complex, ecological valid paradigms. Assuming that Internal consistency reliability of the
they ground in epistemic mistrust, we hypothesize that they arise Spanish adaptation of the
specifically in social contexts requiring an explicit, rather than an
self-compassion scale adapted for
implicit, metaperspective – as it happens in ambiguous, nonliteral
language. children (SCS-C-S)
Methods.– We compared 30 BPD patients with 30 healthy adults E. Fernández Jiménez1* , V. Fernández Jiménez2
1 Hospital Universitario La Paz, Servicio de Psiquiatría- Psicología
on their performance on irony detection and its relation to empa-
thy. Patients met DSM-IV criteria for BPD. Groups were matched on Clínica y Salud Mental, Madrid, Spain; 2 PSYC dissemination,
age, gender, educational level and intelligence. All participants per- International Institute for the Dissemination of the Research in
formed an ecological valid irony detection task containing ironic, Psychology, Córdoba, Spain
literal, praising and critical remarks embedded in video-sequences
and a bilateral “chat history” on a messenger interface, as well as
Background and aims.– The adaptation of extant self-compassion
empathy scales.
measures to other languages is fundamental to compare results
Results.– In BDP patients performance on the irony task was sig-
across countries. However, special attention must be paid to
nificantly lower than in healthy controls (p < .05). Further, ironic
possible understanding difficulties of the items, because self-
but not literal stimuli correlated negatively with empathy scales
compassion can be a complex construct for youths. This is the first
(p < .01).
study to examine a Spanish adaptation of the Self-Compassion Scale
Conclusions.– This study is the first to demonstrate impairments of
adapted for children (SCS-C-S) in an adolescent sample, doing so to
BDP patients in the detection of irony as a pragmatic form of explicit
assure better understanding of the scale items.
mentalization, possibly being associated with a core symptom of
Objectives.– To examine the internal consistency reliability of the
BPD: the dysregulation of emotion.
SCS-C-S in a non-clinical adolescent sample.
Methods.– A sample of 516 adolescents (52.7% females) from the
interest statement.
two high schools of Marchena (a town in the Province of Seville in
Andalusia, Spain) was enrolled. Participants’ age ranged from 14
to 19 years (mean age: 16.15; SD: 1.23). The SCS-C was adapted to
E-PP0804
Spanish by using a forward and back translation process, under the
The Spanish adaptation of the mindful guidance of the authors of the original version of the SCS-C. The
attention awareness scale-children final Spanish adaptation of the scale was pilot tested to check if
(MAAS-C-S): internal consistency the items were correctly understood. To assess internal consistency
reliability in adolescents reliability of the SCS-C-S, alpha coefficients and mean inter-item
E. Fernández Jiménez1* , V. Fernández Jiménez2 correlations (MICs) were computed.
1 Hospital Universitario La Paz, Servicio de Psiquiatría- Psicología Results.– Total score: Cronbach’s alpha = 0.78 and MIC = 0.22; Fac-
Clínica y Salud Mental, Madrid, Spain; 2 PSYC dissemination, tor 1: Cronbach’s alpha = 0.83 and MIC = 0.45; Factor 2: Cronbach’s
International Institute for the Dissemination of the Research in alpha = 0.69 and MIC = 0.27.
Psychology, Córdoba, Spain Conclusions.– The total SCS-C-S score is a reliable measure to assess
* Corresponding author. self-compassion in the adolescent population, while isolating a sec-
ond factor leads to worse internal consistency reliability.
Background and aims.– Measures that assess mindfulness can be Disclosure of interest.– The authors have not supplied a conflict of
too difficult to be understood by adolescents. Therefore, scale items interest statement.
adapted for children could be a suitable option to assess youths on
this dimension.
Objectives.– To examine the internal consistency reliability of the
Spanish version of the Mindful Attention Awareness Scale-Children
(MAAS-C-S) in a non-clinical adolescent sample.
E-PP0806 Results.– The difference between empathy types was medium and
A systemic analysis of the emotional significant in the BPD group (p = 0.009, 2 = 0.10), but small and at
the verge of significance in HCs (p = 0.07, 2 = 0.05).
deregulation and the reality test
Conclusions.– Given the pattern of results in HCs, patients with
impairment in patients with BPD manifested the dissociation between CE and AE. These find-
borderline personality disorder ings seem to support Harari and colleagues’ (2010) suggestion that
D. Galletta* , I. Lauria, M. Confuorto lower-level automatic AE processes may not be effectively regu-
University of Naples Federico II, Neuroscience and Reproductive and lated by higher-order CE processes in BPD.
Odontostomatological Sciences, Naples, Italy Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
Introduction.– The present work aims to continue a previous study E-PP0808
that explored the role of MMPI-2 PSY-5 scales in the BPD diag-
nosis (Galletta et al.). In that study clinically significant elevations
Relationship between personality
emerged both in the PSYC scale and in the NEGE scale, highlight- traits and mental health of coronary
ing difficulties in emotional regulation and transient deficits in the artery disease patients of Fatemeh
reality test (Galletta et al.) in patients with BPD. The present work Zahra Hospital in Sari
analyses the role of MMPI-2 Sc scale and its respective Harris and F. Hadadian1* , B. Babolah2 , N. Maryam3 , D. Sosan4
Lingoes subscales (Sc1, Sc2, Sc3, Sc4, Sc5, Sc6) in the diagnosis of 1 Islamic Azad University of Sari branch, Clinical Psychology, Sari,
BPD. Iran; 2 Payam Noor University Faculty Member Sari, Clinical
Objective.– To demonstrate the correlation between BPD diagnosis, Psychology, Sari, Iran; 3 School of Medicine, Mazandaran University
emotional deregulations, andreality test impairment. of Medical Sciences, Cardiology, Sari, Iran; 4 Islamic Azad University
Methods.– It was administered the MMPI-2 test on a group of sub- Najaf Abad Branch, Health Psychology, Sari, Iran
jects * Corresponding author.
Results.– In patients with DBP there is a significant difficulty in
managing one’s emotions and having control over reality. In fact, Background and aims.–
theSc values are over 70, revealing, consequently, thought disor- Purpose.– The purpose of this study was to investigate the rela-
ders, eccentric behaviours, poor contact with reality, followed by tionship between personality traits and mental health of coronary
a strong emotional impulsiveness (Sc5 > 70) and a strong tendency artery disease patients of Fatemeh Zahra hospital in Sari.
to social isolation (Sc1 > 70). Methods.– This descriptive study was a correlation study. The sta-
Conclusions.– This study highlighted the presence of two funda- tistical population of this study was all coronary artery disease
mental aspects that characterize the personality traits of patients patients referring to Fatemeh Al-Zahra heart surgery hospital in the
with Borderline Personality Disorder. This is very important city of Sari in the first two months of 2012, which were reported
because it affects the treatment process. Acting on these aspects, a about 1999 persons. The sample group was 297 people who were
rapid improvement of the patient can be achieved. selected according to Krejcie and Morgan tables by simple random
Disclosure of interest.– The authors have not supplied a conflict of sampling. They were then evaluated by NEO-FFI personality scale
interest statement. and mental health SCL-90-R.
Results.– Findings showed that there is a significant positive cor-
relation between personality traits and mental health of patients
E-PP0807 with coronary artery disease, so that there is a positive correlation
Further indication of a dissociation between extraversion, adaptability, self-awareness and admission
with mental health of patients with coronary artery disease. There
between cognitive and affective
was a significant negative correlation between neuroticism and
empathy in borderline personality mental health. In addition, the findings showed that personality
disorder traits do have predictive power for mental health.
P. Grzegorzewski Conclusions.– According to the above findings, it is possible to
Institute of Psychiatry and Neurology, Department of Neuroses, improve the prognosis of heart disease with more accurate mon-
Personality Disorders, and Eating Disorders, Warsaw, Poland itoring and training, and by conducting counseling sessions to
control the anxiety and stress of heart patients with high neuroti-
Background and aims.– Self-report studies on empathy in border-
cism and help to control and regulate blood pressure.
line personality disorder (BPD) have built upon the Interpersonal
Reactivity Index (IRI). Nevertheless, the structure of this scale does
interest statement.
not enable for comprehensive measurement of the two broader
dimensions of empathy, differentiated by its contemporary mod-
els, i.e., cognitive (CE) and affective empathy (AE). Additionally, this E-PP0809
line of research has focused almost exclusively on between-group
differences. The results of the only study that has hitherto explored
Implementation of grupal systems
the relevant within-group differences demonstrated higher CE than training for emotional predictability
AE in healthy controls (HCs) and the reverse pattern in BPD, thus and problem solving (STEPPS) in the
suggesting a dissociation between empathy types in this disorder healthcare system of the Basque
(Harari et al., 2010). However, the difference in the second group country (Spain)
was slightly below the level of significance and the IRI was the ques- N. Arnau1 , A. Martinez1 , N. Iriarte2* , P. Sandoval2 , E. Moro1 , A.
tionnaire employed to measure empathy. Therefore, the aim of the Egea1 , C. Pavon2 , G. Garcia2
current study was to investigate the differences between CE and 1 Osakidetza, psychology, vitoria-gasteiz, Spain; 2 Osakidetza,
AE within BPD and HCs groups with the use of a valid self-report psychiatry, vitoria-gasteiz, Spain
tool. * Corresponding author.
Methods.– Thirty women with BPD and 38 healthy women com-
pleted, i.a., the Questionnaire of Cognitive and Affective Empathy, Background and aims.– Borderline Personality Disorder (BPD) is
Raven’s Progressive Matrices, TAS-20, STAI, and CESD-R. a severe medical condition with elevated functional deficits. It
requires frequent clinical assistance in emergency services and con- Conclusions.– Males present more negative consequences caused
stitutes a substantial portion of the caseload. Furthermore, there are by the problematic Generalized Internet Use, being more vulner-
several and non-specific therapeutical responses. This paper aims able than females. Neuroticism, such as gender, is an important
to evaluate the outcomes of STEPPS, which combines cognitive- personality factor in the UGPI aetiology.
behavioral elements and skills training with a systems component. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– STEPPS was implemented in Álava (Spain). Two weekly interest statement.
treatment groups of two hours were carried out between January-
June 2017 and September-May 2018. Inclusion criteria were
defined as having ≥5 criteria of the DSM5 for BPD. Exclusion crite- E-PP0811
ria were substance use disorder, psychopathy and IQ < 75. A sample Prescription of psychotropic drugs in
of 33 participants was analyzed. Data was seeked by descriptive a group treatment program of male
analysis of clinical charts in reduction of parasuicidal attempts, domestic violence perpetrators
emergency care visits and adherence. A quantitative analysis of the P. Michielsen1* , J. Van Wijnen2
self-report questionnaires Borderline Symptoms List (BSL) and Dif- 1 GGZ Westelijk Noord Brabant, Adult Outpatients Clinic, Halsteren,
ficulties in Emotion Regulation Scale (DERS) before, during and at The Netherlands; 2 GGZ Breburg, Outpatient clinic bipolar disorders,
3-month follow-up. Tilburg, The Netherlands
Results.– 72% of our sample completed the treatment. Our anal- * Corresponding author.
ysis showed a decrease of 51% in hospitalizations. Moreover, the
completers showed a reduction of 50% in parasuicidal attempts, Background and aims.–
and remained stable. Also a decrease of emergency care visits was Introduction.– Several guidelines exist on the prescription of psy-
shown until 12-months follow-up. chotropic medication in personality disorders. Little is known about
Conclusions.– The STEPPS program provides an effective approach the rationale and practice in a sample of domestic violence perpe-
to the treatment of BPD, and achieves a significant reduction of trators.
parasuicidal attempts and emergency care visits as the evidence Aim.– To test what categories of psychotropic drugs are prescribed
of previous studies. Further evidence of the effectiveness of this in a sample of male domestic violence perpetrators in a voluntary
program within Osakidetza healthcare system is needed. outpatient treatment program and to assess comorbid personality
Disclosure of interest.– The authors have not supplied a conflict of disorder.
interest statement. Methods.– A cross-sectional retrospective investigation of medical
records was performed in 72 male patients. Personality disorder
diagnosis was established based on DSM-IV-TR criteria. Through
E-PP0810 screening of records (electronic presciption, referral letter, contact
Problematic generalized internet use: with pharmacy) prescription of psychotropic drugs was assessed
the predictive role of neuroticism, before start of the CBT based group therapy program.
extroversion and gender in a sample Results.– 50 out of 72 patients had at least one type of personal-
ity disorder. Most common were antisocial (31/72) and borderline
of Portuguese university students (21/72) personality disorder. The most commonly prescribed drugs
B. Maia1* , A.T. Pereira2 , M.J. Soares2 , H. Moreira3 , A. Macedo2
1 were antidepressants and antipsychotic drugs. Strikingly mood
The Catholic University of Portugal, Faculty of Philosophy and Social
stabilisers were rarely prescribed whereas benzodiazepines were
Sciences- Braga Regional Centre, Braga, Portugal; 2 Faculty of
frequently prescribed in this group. For benzodiazepines General
Medicine University of Coimbra, Institute of Psychological Medicine,
Practitioners were more prone to prescribing benzodiazepines.
Coimbra, Portugal; 3 Faculty of Psychology and Educational Sciences-
Discussion.– The similar prescription patterns in both borderline
University of Coimbra, Center for Research in Neuropsychology and
and antisocial personality disorder raises the question whether
Cognitive-Behavioral Intervention, Coimbra, Portugal
* Corresponding author. impulsive aggression can be treated in a similar way with psy-
chotropic drugs. Psychiatrists should consider mood stabilisers as
Background and aims.– Although the studies about unhealthy Inter- potential first line treatment for impulsive behaviour and affec-
net use have grown considerably in the last two decades, in Portugal tive disregulation in male domestic violence perpetrators with a
the research in this area is sparse. borderline or antisocial personality disorder.
This study aims to explore the associations between and the pre- Conclusions.– More awareness is needed in both GP’s and psy-
dictive role of Neuroticism, Extroversion and gender in Problematic chiatrists about existing guidelines on psychopharmacology in
Generalized Internet Use. impulsive aggression in males with a personality disorder.
Methods.– A sample of 300 Portuguese university students was Disclosure of interest.– The authors have not supplied a conflict of
recruited using a convenience sample. The majority were females interest statement.
(79,7%), single (99%), with a mean age of 20,37 years old (SD = 1,72;
range: 18–25). Participants fulfilled a sociodemographic ques-
E-PP0812
tionnaire, the Portuguese version of the Generalized Problematic
Interne Use Scale 2 and a Portuguese short version of the NEO High rate of fibromyalgia in female
Personality Inventory. patients with borderline personality
Results.– Males presented significant higher scores (Md = 174,19) disorder: a model for hormonal
than females (142,62) in Negative Consequences (U = 5598,500, derangement
z = −2,67, p = ,008). Neuroticism was significant and positively cor- K. Pirkalani1* , Z. Talaeerad2
related with all Problematic Generalized Internet Use (UGPI) fac- 1 Mehr Medical Group, Internal Medicine/Psychiatry, Tehran, Iran; 2
tors: Preference for Online Social Interaction (rho = ,175**, p = ,003), Mehr Medical Group, Internal Medicine/Gynecology, Tehran, Iran
Mood Regulation (rho = ,285**, p = ,000), Deficient Self-regulation * Corresponding author.
(rs = ,238**, p = ,000) and Negative Consequences (rho = 233**,
p = ,000). Extroversion was significant and negatively correlated Background and aims.–
with Preference for Online Social Interaction (rho = -,192**, p = ,001) Introduction.– Fibromyalgia and borderline personality disorder
and Mood Regulation (rho = −,152*, p = .011). Neuroticism was a have many phenomenological points in common. Both show higher
significant predictor of all UGPI factors and Gender was also a sig- propensity in females, both are inherently unstable and both show
nificant predictor of Negative Consequences.
a deranged and unstable response to pain. Besides, psychological Conclusions.– Consistently with literature, in our sample BPD
hallmarks of fibromyalgia resembles a moderate compensated bor- patients seem to over-experience endogenouspain, with a ten-
derline. dency of anti-inflammatory abuse.
Objectives.– We wondered whether these two items have common Disclosure of interest.– The authors have not supplied a conflict of
etiologies or psychopathologies. interest statement.
Methods.– From our reservoir of more than 12000 patients under
continuous study, hundred eighty two patients with fibromyalgia
(confirmed diagnosis based of guidelines of the American society of E-PP0814
rheumatology) (age range 23–59) and 312 patients with confirmed Neural correlates of social cognition
borderline personality disorder based on APA (age range 19–51), related to scenes of mourning in
clinical interview and MCMI-III were compared.
borderline personality disorder
Results.– Of 182 patients with fibromyalgia, 168 (92%) fulfilled the
Z. Sosic-Vasic1* , J. Eberhardt1 , J.E. Bosch1 , L. Dommes1 , K. Labek2 ,
criteria of borderline personality disorder (mostly the avoidant,
A. Buchheim2 , R. Viviani2
dependent or the schizotypal subtype) and of 312 patients with 1 University Clinic of Ulm, Dep. Psychiatry and Psychotherapy III,
borderline personality disorder 300 showed signs of fibromyalgia
Ulm, Germany; 2 University of Innsbruck, Institute of Psychology,
and 254 (81%) fulfilled the criteria.
Innsbruck, Austria
Conclusions.– Based on the above, these two entities are either phe- * Corresponding author.
nomenological the same or have a pathophysiological pathway. As
most of the signs and symptoms of both disease respond partially Background and aims.– Instability in interpersonal relations is a
or completely to a combination of Duloxetine +Pregabaline we con- core feature within borderline personality disorder (BPD). Previous
clude that pain expression and feeling frustrated are both covered. studies have pointed to neural dysregulation in areas associated
Muscle relaxant arise a moderate response in fibromyalgia patients with negative affect such as increased amygdala activity. How-
and curiously a moderate response in borderline instability and ever, even though far less intensively investigated, accumulating
rage as well. Gathering sign and symptoms and reporting a new findings have drawn attention to deficits in social cognition and
disease entity was a common practice but must be abandoned dur- their likely role in engendering emotional instability. We there-
ing the new era of molecular medicine where hormonal status must fore assessed neural correlates of social cognition in BPD within a
be scrutinized. functional imaging study (fMRI).
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Using a passive-viewing paradigm, we exposed 20
interest statement. patients with BPD and 20 healthy controls to blocks of stylized
drawings of scenes of mourning – as the topic of loss and sepa-
ration is of high relevance to BPD patients -, scrambled pictures
E-PP0813 (baseline), and control drawings during fMRI (3 T).
Pain and anti-inflammatory abuse in Results.– BPD individuals compared to healthy controls exhibited
borderline personality disorder, major increased activation in a cluster comprising the left sensorimotor
psychiatric disorders and healthy cortex and the left dorsal posterior insula when viewing mourning
pictures vs. control pictures. In addition, for both groups an effect
controls
of a positive trend over time was observed in the inferior frontal
M. Pacetti1 , F. Ambrosini2 , R.P. Sant’angelo3*
1 gyrus. However, this effect was reduced for patients with BPD.
Ausl Romagna, Mental Health, Forli, Italy; 2 University of Bologna,
Conclusions.– Our findings point to possibly less sophisticated social
Faculty of Psychology, Cesena, Italy; 3 Ausl Romagna, Mental Health,
cognition capacities among patients with BPD as reflected by
Cesena, Italy
* Corresponding author. increased mirror neuron system activity relevant to the encoding
of rather basic aspects of the perception of motoric activity and
Background and aims.– Individuals affected by Borderline Person- pain, and decreased inferior frontal gyrus activity relevant to more
ality Disorder (BPD) show a low tolerance to endogenous chronic complex aspects of social cognition.
pain, with a tendency to abuse of anti-inflammatories. However, Disclosure of interest.– The authors have not supplied a conflict of
within these aspects, BPD patients have rarely been compared with interest statement.
major psychiatric disorders and healthy controls.
The study aims to compare BPD individuals with patients with
Psychosis (P), Affective Disorder (AD) and Healthy Controls E-PP0815
(HC) in the presence of musculoskeletal pain and in the anti- Inhaled loxapine for agitation in
inflammatory/analgesic abuse. patients with personality disorder: a
Methods.– A sample of 112 subjects without diagnosis of case series
osteoarthritis was collected. The whole sample was divided in Ó. Soto* , S. Vargas, R. Lidai, A. López, M.D.L.Á. Torrecilla, C.
four groups: 27 (24.1%) subjects with BPD, 27 (24.1%) with P Fadeuilhe, R.F. Palma-Álvarez, P. Ibañez, J.A. Ramos-Quiroga, M.
(Schizophrenia, Schizoaffective Disorderand Delusional Disorder), Ferrer
25 (22.3%) with AD (Unipolar Depression and Bipolar Disorder) and Vall d’Hebrón University Hospital, CIBERSAM, Psychiatry, Barcelona,
33 (29.5%) HC. Using chi-squared test and logistic regressions, BPD Spain
were compared with the other groups in: presence of headache, * Corresponding author.
back pain, joint pain; intensity of pain during the assessment and
within the week before the assessment; subjective experience of Background and aims.– Agitation is common among patients
pain and the abuse of anti-inflammatories and analgesics. diagnosed with personality disorders, specially those with
Results.– Considering separately the pain variables, BPD exhibit impulsivity-related personality traits. Managing such episodes
headache and joint pain more frequently than the other groups. might pose a challenge for professionals. Inhaled loxapine has
With respect to P and AD patients, BPD individuals have a strong proven to be effective in treating agitation in patients with psy-
subjective experience of pain and refer a more severe intensity of chotic symptoms, but its usefulness in personality disorder (PD)
pain both during the assessment and during the week before. BPD patients is not well documented yet.
subjects resulted to abuse more frequently of anti-inflammatory This study aimed to assess whether inhaled loxapine is an effective
and analgesics than the other groups. and safe treatment for acute agitation in patients with PD.
Methods.– We developed a naturalistic, prospective study approved E-PP0817

by The Hospital Ethics Committee and registered at the Spanish Influence of training situations on
Clinical Studies Registry (EuraCT 2016-004884-38). Eleven patients
structure and function of cognitive
with PD diagnosis (according to DSM-5 criteria) were recruited. The
following variables and tools measured efficacy and safety:
states
Time between administration and effect A. Timirgaleev* , A. Prokhorov Oktyabrinovich, A. Chernov
Evaluation with CGI-Scale, PANSS-EC and ACES scale. The symp- Valentinovich, M. Yusupov Gennadjevich, M. Valiullina
toms were measured at 10, 20 and 60 minutes after administration. Evgenjevna, A. Khalfieva Ramiljevna
Safety was assessed by a list of side effects. Kazan Volga Region Federal Unversity, General Psychology, Kazan,
Results.– These are the preliminary results with 11 patients from Russia
an expected final sample of 30. Nine people with agitation were
diagnosed with Borderline PD and 2 with Antisocial PD. The base- Background and aims.– Cognitive mental states are actualized in the
line total scores for CGI-S, PANSS-EC and ACES scales were 4.3, 20.5 process of interaction between subject and object of cognition. The
and 2.3, respectively. At 60 minutes, CGI-S and PANSS-EC scores result is the cognitive transformation of object and the deepening
decreased 70% and 76%, respectively, and the ACES score improved on this basis of cognition. From the system approach point of view,
almost double. No patient needed pharmacological reintervention the cognitive state is viewed as a functional system that integrates
with loxapine, another drug or used mechanical restraint. No sig- those processes and properties that are necessary for the effective
nificant side effects were observed. performance of activities.
Conclusions.– According to these preliminary results, inhaled loxap- The main study purposes are to reveal the phenomenological fea-
ine could be a useful and safe option for managing agitation in PD tures of students’ states depending on the form of educational
patients. activity, to reveal the composition of states, the structure leading
Disclosure of interest.– The authors have not supplied a conflict of components, functions realized in learning process.
interest statement. Methods.– The study procedure included: the diagnosis of students
personality traits and cognitive abilities, the measurement of cogni-
tive states characteristics during lecture, seminar and examination.
E-PP0816
The statistical processing of study results was carried out by factor
The concept of borderline personality analysis method. The sample of the study was made up of students
disorder as a bipolar spectrum disease of various specialties, totally 143 people. Respondents’ average age
T. Teodoro1* , F. Couto Gomes2 , I. Pinto2 , S. Vilas-Boas Garcia2 is 19.7 years.
1 Centro Hospitalar Psiquiátrico de Lisboa- NOVA Medical School - Results.– It is established that, depending on learning situations, the
Universidade Nova de Lisboa, Psychiatry, Lisbon, Portugal; 2 Centro cognitive states perform the functions of activating the intrapsychic
Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisbon, Portugal orientation (lecture), activating cognitive activity and mobiliz-
ing intellectual resources (seminar), self-regulation of educational
activities and its emotional states (exam).
Background and aims.– Borderline personality disorder (BPD) is one Conclusions.– It is shown that the degree of cognitive states inte-
of the most extensively studied personality disorders and its con- gration increases with the intensifying of situation, the role of
cept has its origins in psychoanalytical principles. This disorder self-regulation indicators and the value-semantic sphere in the
has been subject of controversy namely in terms of its potential integral structure of the state increases.
relationship with the diagnosis of bipolar disorder. The aim of this Disclosure of interest.– The authors have not supplied a conflict of
work is to review current evidence placing borderline personality interest statement.
disorder as part of the bipolar spectrum concept and its potential
therapeutic implications.
Methods.– A non-systematic review of literature was performed
using Pubmed with the following keywords: “borderline person- E-Poster Presentation: Personality and
ality disorder”; “bipolar disorder”; “bipolar spectrum”. Personality Disorders - Part II/Neuroscience in
Results.– BPD and BD have several overlapping symptoms which
Psychiatry - Part II
obscure the relationship between these two nosological entities.
Epidemiological studies show that, according to current diagnostic
criteria, about 20% of BPD are also diagnosable as BD. The overlap-
ping symptoms include affective instability, impulsivity, psychotic E-PP0818
symptoms and sleep changes. Some authors identify other symp- Similarities and differences in the
toms as strong predictors of each diagnosis, including recurrent hexaco dimensions and psychological
self-harm, interpersonal and self-image instability, chronic feel- distress across the dark triad
ing of emptiness, among others in favor of the BPD diagnosis. A A. Araújo1* , A. Pereira2 , C. Cabaços2 , C. Marques2 , N. Madeira2 , V.
recent genome-wide association study found evidence of overlap Nogueira2 , A. Macedo2
between. BPD, BD, unipolar depression and schizophrenia. Here we 1 Faculty of Medicine, University of Coimbra, Institute of
present an overview of the most recent literature on this subject, Psychological Medicine, Coimbra, Portugal; 2 Institute of
including neurobiological and genetic evidence in favor and against Psychological Medicine, Faculty of Medicine, Coimbra University-
the validity of BPD as a diagnostic entity. Portugal, Coimbra, Portugal
Conclusions.– The exact nature of the relationship between BPD and * Corresponding author.
BD remains unclear with several conflicting points of view. Fur-
ther studies focusing on this subject are necessary since there are Background and aims.– The Dark Triad (DT) refers to three
potential therapeutic and prognostic implications. socially aversive personalities – Narcissism, Psychopathy and
Disclosure of interest.– The authors have not supplied a conflict of Machiavellianism – characterized by a behavioral style oriented
interest statement. towards self-benefit through socially exploitative dispositions.
The HEXACO model of personality postulates that personal-
ity structure consists of six dimensions, mirroring two broad
concepts – Honesty-Humility, Agreeableness and Emotionality
(reciprocal/kin altruism); Extraversion, Conscientiousness and
Openness-to-Experience (engagement within different areas). chological distress explained 28.5% of SDIDF variance, and SDI and
Aim: To study: a) correlations between the DT, the HEXACO dimen- Neuroticism were the significant predictors.
sions, and psychological distress; b) the mediator role of HEXACO Conclusions.– Sleep difficulties and neuroticism independently con-
dimensions on the relationship between DT and psychological distributed to impairments in daytime functioning. Psychological
tress. distress was also implicated in this outcome. These variables might
Methods.– 632 university students (65.5% girls, mean aged be considered to improve the quality of life of students with sleep
21,4 ± 2,28 years) answered the Portuguese versions of the Dirty problems.
Dozen, HEXACO-60 and Depression, Anxiety and Stress Scales. Cor- Disclosure of interest.– The authors have not supplied a conflict of
relation/mediation analyses were performed using PROCESS macro interest statement.
for SPSS.
Results.– The DT showed negative correlations with Honesty-
Humility and Agreeableness. Emotionality was positively corre- E-PP0820
lated with Narcissism and negatively correlated with Psychopathy Repetitive glass ingestion in a patient
and Machiavellianism. Low Honesty-Humility was a mediator in with personality disorder
the relationship between Narcissism and Depression/Stress; and V. Chiappetta1* , A. Kadhivi2 , R. Amazan1 , S. Gunturu1 , K. Shah1 , P.
between Psychopathy and Depression. Low Agreeableness was Korenis1
a mediator in the relationship between Narcissism and Anxi- 1 BronxCare Health hospital, Psychiatry, Icahn School of Medicine at
ety/Stress; and between Psychopathy and Anxiety. Emotionality Mount Sinai, Bronx, USA; 2 BronxCare Health hospital, Psychiatry,
was a mediator in the relationship between Narcissism and Albert Einstein Collegue of Medicine, Bronx, USA
Depression/Anxiety/Stress; and between Psychopathy and low * Corresponding author.
Depression/Anxiety.
Conclusions.– While all the DT traits showed common correlates Background and aims.–
with low Honesty-Humility and Agreeableness (“unification the- Introduction.– Intentional foreign body ingestion occurs among a
ories”), only Narcissism and Psychopathy predicted psychological relatively small number of patients with psychiatric disorders;
distress (“discrimination theories”). Narcissism had the most con- however, it is potentially very harmful and costly. Literature
sistent link with psychological distress. The distinct relations of is remarkably sparse, with discussions of associated psychiatric
Emotionality (high in Narcissism and low in Psychopathy and symptoms and treatments limited. Most reports on intentional
Machiavellianism) across the DT partially explains these outcomes. swallowing are found in the surgical and gastroenterological litera-
Disclosure of interest.– The authors have not supplied a conflict of ture. They contain little to no commentary about patient intentions,
interest statement. or psychopathology. Self-injurious behavior is a fairly common
phenomenon in psychiatric patients, particularly those with severe
personality disorders.
E-PP0819 Objectives.– We aim to help characterize the association between
The effect of sleep difficulties, big-five foreign body ingestion and psychiatric disorders by presenting a
personality traits and psychological case report of a young man with borderline personality disorder
and polysubstance use, who repeatedly swallowed pieces of glass
distress on daytime functioning
as a form of self-injury.
M.J. Soares1 , C. Cabaços1* , M. Marques1,2,3 , A.T. Pereira1 , S.C. Bos1 ,
Methods.– Case report: 37-year-old Caucasian male who was
A.P. Amaral1,4 , A. Macedo1,3
1 Faculty of Medicine- University of Coimbra- Portugal, Institute of admitted for a fourth time after ingesting a foreign body in the con-
text of suicidal ideation. The patient has a past psychiatry history of
Psychological Medicine, Coimbra, Portugal; 2 Miguel Torga Higher
mood disorder, borderline personality disorder, and polysubstance
Institute, Higher Institute, Coimbra, Portugal; 3 Coimbra Hospital and
use. His history is notable for multiple ED visits after ingesting bro-
University Centre, Psychiatry, Coimbra, Portugal; 4 Institute
ken glass, resulting in multiple endoscopic procedures (28 pieces
Polytechnic of Coimbra- ESTESC, Coimbra Health School, Coimbra,
of glass removed by colonoscopy).
Portugal
* Corresponding author. Results.– Repetitive foreign body ingestion is often impulsively
driven and difficult to treat. As such, it results in frequent yet inef-
Background and aims.– Sleep problems may have adverse effects on fective medical treatment. Morbidity from the ingestion itself and
associated daytime functioning. the procedures to remove the foreign bodies lends itself to an ele-
Objectives.– To analyse if sleep difficulties, personality, and psy- vated financial burden for the health care system.
chological distress were associated/predictive of sleep difficulties Conclusions.– Understanding behavioral factors is critical for devel-
interference in daytime functioning (SDIDF). oping collaborative treatment strategies for patients suffering from
Methods.– 242 university students (78.9% women), aged 18–25 this life threatening, self-injurious condition.
years completed the NEO-FFI-20, DASS-21, and three questions to Disclosure of interest.– The authors have not supplied a conflict of
assess the difficulties in initiating (DIS), maintaining sleep (DMS) interest statement.
and early morning awakening (EMA). Summing these items scores
a sleep difficulties index (SDI) was calculated. An item assessed
SDIDF (daily life, activities, behaviour/mood) and five groups were E-PP0821
constructed, based on its answer options: 1-none; 2-very little, 3-a Obsessive-compulsive personality
little; 4-a lot; 5-very much. disorder and its expression in the
Results.– DIS, DMS and EMA (3/4 nights a week or almost every perinatal
night) were reported by 9.1%, 7.8% and 5.4%, respectively. 99 (24.4%) V. Placenti1 , E. Di Giacomo2* , F. Colmegna3 , R. Pessina1 , F.
of the students reported none SDIDF and 183 (75.6%) reported Pescatore4 , M. Clerici2
having SDIDF. Very little SPIDF was reported by 62 (25.6%) of the 1 University of Milan-Bicocca, Psychiatry, Monza, Italy; 2 ASST
students, little SPIDF by 87 (36%), a lot by 23 (9.5%) and very much by Monza-University of Milano-Bicocca, Psychiatry, Monza, Italy; 3 ASST
11 (4.5%). Women revealed higher levels of SDIDF. Students groups Monza, Psychiatry, Monza, Italy; 4 Psychiatric Residency Training
reporting SDIDF revealed higher levels of SDI, neuroticism and psy- Program – University of Milano – Bicocca Italy, Psychiatry, Monza,
chological distress than the group that reported none SDIDF. In a Italy
hierarchical regression analysis, gender, SDI, neuroticism and psy- * Corresponding author.
Background and aims.– give way to biomarkers for the evaluation of outcomes in Psychia-
Background.– The post-partum has been associated with an try, supporting novel clinical interventions.
increased onset or recurrence of several psychiatric disorders. Disclosure of interest.– The authors have not supplied a conflict of
Despite the lack of data, obsessive-compulsive personality disorder interest statement.
(OCPD) shows a higher incidence during post-partum.
Aims.– Assessing the prevalence of OCPD during post-partum and
socio-demographic, reproductive and psychopathological conse- E-PP0823
quences in affected women. A case of anti-nmda receptor
Methods.– 154 patients (PTS) from the perinatal psychiatric depart- encephalitis revealed by psychiatric
ment, and a control group of 61 women from a screening program
manifestations
for perinatal psychiatric disorders (HC) were given the SCID II,
H. Maatallah* , R. Damak, I. Berrahal, N. Ghazouani, M. Cheour
EPDS, BDI, BAI, WHOQoL, CTQ after the first psychiatric examina-
Razi Hospital, Psy E, Tunis, Tunisia
tion. Their socio-demographic, psychopathological and obstetrical * Corresponding author.
characteristics were collected.
Results.– OCPD was significantly higher in PTS than in HC (29,5% Background and aims.– Anti-NMDA receptor encephalitis is an
vs. 8,4%; p = 0.0002). Both the rates were higher than those in autoimmune disease that was identified in 2007, and manifests in
the general population (2,1%–7,9%) and within psychiatric out- a stepwise manner with psychiatric, neurological and autonomic
patients (8.7%). OCPD-PTS showed worse symptoms of anxiety symptoms. This disease is caused by autoantibodies against NMDA
and a reduced perception of their psychological well-being than receptors and can affect both sexes and all ages.
OCPD-HC. The same results were observed comparing OCPD-PTS Objectives.– To understand clinical presentation of anti-NMDA
to patients affected by borderline and narcissistic personality receptor encephalitis and its management
disorders and those suffering from mood disorders among PTS. Methods.– To illustrate psychiatric manifestations of anti-NMDA
OCPD-PTS showed less obstetrical complications compared to receptor encephalitis: a case report and review of the literature
OCPD-HC. Interestingly, OCPD-HC showed higher social with- Results.– A 49-year-old woman was admitted to an inpatient unit
drawal, with significant less women with a active job (38% vs 84.6%, for depression with suicide attempt and insomnia. She also suffered
p = 0.01). of abnormal movements of the face. All laboratory investigations
Conclusions.– A recrudescence of OCPD is more frequent during the and imaging were negative. Antibodies for anti-NMDA receptors
post partum. In this period, women affected by OCPD experience were positive in serum. She received methylprednisolone 1 gr per
higher psychological distress than those affected by other major day for 5 days and initiated on lorazepam 2 mg/day with mild clin-
psychiatric disorders. ical improvement. But the patient refused to continue treatment
Disclosure of interest.– The authors have not supplied a conflict of with immunoglobulin.
interest statement. Conclusions.– This case highlights that we should be suspect the
anti-NMDA receptor encephalitis when the psychiatric symptoms
are accompanied by extrapyramidal symptoms, autonomic dys-
E-PP0822 function and neurological decompensation. More research and
The dissection of a mortal sin - envy dissemination of knowledge is required to improve clinicians’ abil-
T. Duarte* , J. Crawford, M. João Centento, T. Fialho, P. Godinho ity to make the diagnosis of anti NMDA receptor encephalitis.
Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, E.P.E., Disclosure of interest.– The authors have not supplied a conflict of
Serviço de Psiquiatria e Saúde Mental, Lisboa, Portugal interest statement.
Introduction.– Humans have a drive to evaluate themselves by
examining their abilities in comparison to others. Envy is the pain E-PP0824
caused by the good fortune of others, and a manifestation of pri- Adenomatous polyposis coli protein
mary destructiveness, to some extent constitutionally based. and its link to autism and
It is comprised of the wish to abolish inferiority by either having
another person’s possession or success and/or the wish that the
schizophrenia
A.S. Machado* , V. Covelo, R. Grangeia
other person did not possess the desired characteristic or object.
Centro Hospitalar Universitário de São João, Clínica de Psiquiatria e
On the other hand, gloating or schadenfreude denotes one’s joy
Saúde Mental, Porto, Portugal
about the shame or misfortune of another. * Corresponding author.
Envy does not elicit a unique affective state or facial expression.
It is a complex mix of unpleasant psychological states - inferi- Background and aims.– The adenomatous polyposis coli (APC) locus
ority, injustice, and resentment - which tend to be intentionally has been proposed as a predisposing gene to autism spectrum dis-
concealed from others. orders and schizophrenia. There is an increasing understanding of
In DSM5 envy is underrepresented only appearing as a character- the role of APC protein in the central nervous system that unveils
istic of Antisocial and Narcisic Personality Disorders. a possible relation to the pathophysiology of these disorders.
Objectives.– Non-systematic literature review on envy and it’s cor- Methods.– Literature review was based on PubMed/MEDLINE, using
relate with neurobiological findings. the keywords “APC”, “adenomatous polyposis coli” and “psychia-
Methods.– Pubmed database was searched between 2010 and 2018 try”.
and articles with the words “envy”, “fMRI” and “emotion” were Results.– The APC protein is found localized in many cell types
included. including neurons in the adult rodent brain. A high level of expres-
Results.– An effective tool for measuring the activation of specific sion of the APC mRNA is observed during brain development in rats.
areas in the brain is fMRI. The ventral striatum plays a major role The recent evidence suggests that APC coordinates presynaptic and
in the reward system. An increased ventral striatum activation postsynaptic maturation and thereby ensures synaptic efficacy. The
was verified with blood-oxygen-level dependent contrast imag- disruption of synapse formation has been associated both to APC
ing whenever envy was detected. Regional homogeneity in the and schizophrenia. The loss of APC function in forebrain neurons led
inferior/middle frontal gyrus and dorsomedial prefrontal cortex to cognitive and autism-like phenotypes in rats. Furthermore, APC
positively predicted dispositional envy. is also a key component of the Wnt/Wingless signaling transduc-
Conclusions.– An association between neural representations of tion pathway that is suggested to be disturbed in schizophrenia.
envy and theories of emotional processing is suggested. This may
Although there are a few case reports of schizophrenia in famil- E-PP0826

ial adenomatous polyposis (FAP) patients with identified APC Functional connectivity between
mutations, there is only one pilot study regarding the study of
dorsolateral prefrontal cortex and left
neurocognitive performance and brain structure of these patients.
Conclusions.– The description of neural functions of APC can provide
temporal language-related region in
some insight into the complex molecular mechanisms underlying the first-degree relatives of patients
these neurodevelopmental disorders. The assessment of the neu- with schizophrenia
rocognitive features in FAP patients may help to determine APC ‘s Y. Panikratova1* , I. Lebedeva1 , A. Pomytkin1 , U. Popovich2 , P.
role in normal cognition and behavior. Kananovich2 , A. Rumshiskaya3 , V. Kaleda2
Disclosure of interest.– The authors have not supplied a conflict of 1 Mental Health Research Center, Laboratory of neuroimaging and
interest statement. multimodal analysis, Moscow, Russia; 2 Mental Health Research

Center, Department of endogenous mental disorders and affective
states, Moscow, Russia; 3 Davidovskiy City Clinical Hospital,
E-PP0825 Radiology department, Moscow, Russia
The role of endoplasmic reticulum
stress in the innate immune system in Background and aims.– One of the approaches to studying neu-
bipolar disorder robiological markers of schizophrenia, its traits or so-called
A.C. Pereira1 , I. Ferreira1 , B. Neves2 , D. Moura3,4* , S. Morais3,4 , N. endophenotypes, is an examination of unaffected first-degree
Madeira3,4 , A. Macedo3,4 , M.T. Cruz1,5 , C. Pereira1,6 relatives. Patients with schizophrenia with auditory verbal hal-
1 University of Coimbra, Center for Neuroscience and Cellular Biology
lucinations have demonstrated altered (decreased) functional
CNC, Coimbra, Portugal; 2 University of Aveiro, Department of connectivity (FC) between regions of the brain, involved in execu-
Medical Sciences and Institute for Biomedicine iBiMED, Aveiro, tive functions and language (dorsolateral prefrontal cortex [DLPFC]
Portugal; 3 Centro Hospitalar e Universitário de Coimbra CHUC- and left temporal regions in particular). It seems, however, that
Portugal, Department of Psychiatry, Coimbra, Portugal; 4 Faculty of the analysis of similar FC in the genetic risk group has yet to be
Medicine- University of Coimbra, Institute of Psychological Medicine, done. The aim of this study was to investigate whether FC between
Coimbra, Portugal; 5 University of Coimbra, Faculty of Pharmacy, the DLPFC and left temporal language-related region is altered in
Coimbra, Portugal; 6 Faculty of Medicine- University of Coimbra, unaffected first-degree relatives of patients with schizophrenia.
Institute of Biochemistry, Coimbra, Portugal Methods.– First-degree unaffected relatives of persons with
schizophrenia (12 subjects) and affective spectrum disorders (12
subjects), as well as healthy individuals without family history
Background and aims.– Bipolar disorder (BD) is a mental illness char-
of mental disorders (13 subjects) underwent resting-state func-
acterized by mood swings between depression and mania resulting
tional magnetic resonance imaging at 3T Philips scanner. Three
in cognitive and functional impairments that require lifetime treat-
regions of interest (ROIs) for ROI-to-ROI analysis were taken from
ment. Delayed diagnosis is frequent because biomarkers are absent.
Shirer’s atlas (https://findlab.stanford.edu/functional ROIs.html).
Therefore, a better understanding of BD pathophysiology is crucial.
FC between ROIs (left/right DLPFC from left/right executive net-
Impaired cellular resilience, compromised endoplasmic reticulum
work, on the one hand, and left temporal region from the language
(ER) stress response, mitochondrial dysfunction and changes in
network, on the other hand) was compared pairwise between
innate immunity have been implicated in BD pathophysiology.
groups.
Given that these events are associated with ER-mitochondria junc-
Results.– As compared to controls, the relatives of patients with
tions, called Mitochondria-Associated Membranes (MAMs), this
schizophrenia were characterized by increased FC between the left
study addressed the role of MAMs on ER stress-induced sterile
DLPFC and language-related region in the left posterior middle tem-
inflammation in BD.
poral gyrus.
Methods.– As cellular models of the innate immune system, human
Conclusions.– The findings might reflect some compensatory
THP-1 monocytes and monocytes isolated from early stage BD
functional processes in unaffected first-degree relatives of
patients versus controls (N = 5 per group) were used, under basal
schizophrenic patients. The study was supported by RFBR grant
or stressful conditions. Protein levels of ER stress markers were
№17-06-00985.
evaluated by Western Blot (WB) and activation of the NLRP3 inflam-
masome was analyzed by ELISA. ER-mitochondria contacts were
interest statement.
evaluated by determining protein levels of MAM’s components
by WB. Functional parameters were also investigated under simi-
lar conditions in THP-1 monocytes, namely mitochondrial reactive
E-PP0827
oxygen species (ROS) production and membrane potential, using
MitoSox and TMRE fluorescent probes. Assessing psychosis in clinical practice
Results.– ER stress induces NLRP3 inflammasome activation in using auditory event related
THP-1 monocytes and BD patient-derived monocytes and affect potentials
ER-mitochondria contacts at MAMs. Data obtained in THP-1 F. Passos1* , M. Constante1 , C. Ribeiro1 , M. Gani2 , J. Sanches2 , M.J.
cells suggest that ER-mitochondria communication in ER stressed Heitor1
monocytes promotes NLRP3 activation by a mitochondrial ROS- 1 Hospital Beatriz Ângelo, Psychiatry, Lisbon, Portugal; 2 Instituto
independent mechanism. Superior Técnico, Bioengineering Department, Lisbon, Portugal

Conclusions.– This study provides a proof-of-concept for “MAM * Corresponding author.
hypothesis” for BD innate immunity deregulation and can unveil

novel targets for early therapeutic intervention. Background and aims.– Event-Related Potential (ERPs) provide
Disclosure of interest.– The authors have not supplied a conflict of EEG derived measures of brain function commonly used to study
interest statement. psychosis. ERPs are however commonly obtained in lab condi-
tions (e.g. shielded room), by trained researchers, during lengthy
recording sessions, with large electrode montages and require
time-consuming post recording expert classification, all of which
may hinder ERPs use in routine clinical practice.
Methods.– A short testing setup was designed to combine an E-PP0829

auditory oddball task, a paired-click gating paradigm and a Attitudes towards death among
duration-deviant passive auditory oddball paradigm. Subjects
health care professionals (HCP) and
underwent auditory stimulation and simultaneous EEG recording,
in an interview room setting, performed by a clinician (psychia-
their perceived well-being at Aga
trist/psychologist). A fully automatic analysis algorithm measured Khan University (AKU)
ERPs at 3 scalp electrode sites, using EEGLAB and custom made Mat- S.A. Siddiqui, M. Khan Shameel* , A. Chachar Sanober
lab scripts. Altogether, subject briefing, testing task, data analysis Aga Khan Univeristy, Psychiatry, Karachi, Pakistan
and results display were completed in about 30 minutes. 76 psy-
chosis patients and 41 healthy age and gender-matched controls
Background and aims.– Death is a complex construct to understand
were tested and ERPs between-group comparisons were made with
as it is influenced by the perceptions that HCP may have regarding
repeated measures ANOVA.
end of life. Understanding these perceptions helps in addressing
Results.– The testing setup was able to elicit classic ERPs from
death anxiety in HCP which can otherwise negatively influence
the studied neurophysiological paradigms (Fig. 1–3). Moreover,
physician well-being and patient interactions such as breaking bad
previously published psychosis patients deficits were replicated,
news.
F(2,226) = 13.2, p < 0.00001, P300 amplitude = 3,71 ␮V, 95%
Methods.– This is a cross-sectional study on 109 HCP including
CI = 1.96 to 5.45 ␮V, MMN amplitude = 0.90 ␮V, 95% CI = 0.41 to
nurses (n = 29), physicians (n = 43), resident (n = 25) and interns
1.40 ␮V, P50 ratio = −0.22, 95% CI = −0.41 to −0.04.
(n = 12) across various specialties at AKU. Death anxiety was
Conclusions.– Psychosis brain function abnormalities elicited
assessed through the death attitude profile revised scale and its
through auditory ERPs can be measured under common clinical
correlation was seen with the perception of one’s own wellbeing
practice conditions.
through Perceived well-being scale. A semi-structured pro-forma
was used to collect demographic data.
interest statement.
Results.– The results showed that death anxiety was highest in
interns (150.83 ± 17.94) followed by nurses (139 ± 20.67), residents
(137.84 ± 15.79) and physicians (137.99 ± 21.59) and perceived
E-Poster Presentation: Philosophy and Psychiatry well-being was lowest in interns (71.00 ± 10.10) followed by
nurses (72.41 ± 10.43), residents (74.16 ± 12.83) and physicians
(75.98 ± 12.19). The results of this study demonstrated a negative
correlation between death anxiety and perceived well-being.
E-PP0828
Conclusions.– The negative correlation between death anxiety and
Genetic determinism, psychiatry and perceived well-being suggest that health care professionals are
place most vulnerable in the preliminary years of their career. It is there-
M. Gildersleeve* , A. Crowden fore recommended that psychology of death and dying is given
University of Queensland, Historical and Philosophical Inquiry, St equal weightage in medical curriculum to enable physicians deal
Lucia, Australia effectively with the trauma of bereavement and loss relating to or
patients.
Background and aims.– We review genetic determinism and interest statement.
highlight how our earlier research on psychoanalysis and the phi-
losophy of place (see Gildersleeve, Crowden, 2018) can contribute
to a better understanding of its relationship to psychiatry. E-PP0830
Methods.– We show how integrating place with psychoanalysis can
Two-eyed seeing as a philosophy to
undermine any philosophy of genetic determinism. We achieve this
by demonstrating the prevalence of genetic determinism in the facilitate communication between
media, education and in debates on genetic modification. We also indigenous knowledge keepers and
utilise research on the film GATTACA to conceptualise how place psychiatry about mind and mental
and genetic determinism contrast and why place coupled with health
psychiatry are an important antagonist to the ideology of genetic L. Mehl-Madrona1 , B. Mainguy2* , P. McFarlane3
determinism. 1 University of Maine, Graduate School, Orono- Maine, USA; 2
Results.– By using our philosophy of place, our investigation high- University of Maine at Orono, School of Social Work, Orono, USA; 3
lights how psychiatry can contribute to a call for humanity to turn University of New England, Bangor Campus, Family Medicine,
toward a “collective being-at-home-in-the-world”, instead of being Bangor, USA
estranged from place which the rhetoric of genetic determinism * Corresponding author.
unconsciously but actively promotes.
Conclusions.– Our examination intends to integrate psychiatry Background and aims.– A communication gap exists between psy-
into ongoing discussions about genetic determinism as they play chiatry and indigenous people about views of mind and mental
out in the media, education and influence discrimination. We health. Indigenous knowledge and its keepers have been called
show something that has not been considered before. Specifically, primitive, superstitious, under-educated, and dismissed as wrong.
our philosophy of place combined with psychoanalytic principles A need exists to develop a philosophy to facilitate better commu-
shows the potentially dangerous implications of genetic deter- nication among indigenous people and psychiatry.
minism. Fundamentally, we argue that genetic determinism leads Methods.– The term “two-eyed seeing” is spreading across North
to mental illness through the formation of psychopathological America as a concept for explanatory pluralism. The concept was
obstructive complexes because an individual is estranged from brought into academic science by Albert Marshall, a M’iqmaq from
their authentic place in the world. We show the media and educa- Nova, Scotia, Canada. It speaks to the idea that indigenous knowl-
tional programs plays an important role in this and why scholars in edge is an equally valid way of conceptualizing a phenomena as is
these areas should consider place and genetic determinism along- contemporary science. Marshall’s famous example compares a tra-
side psychiatry in their future theoretical and practical endeavours. ditional M’iqmaq story about the origins of the large tides in the Bay
Disclosure of interest.– The authors have not supplied a conflict of of Fundy with contemporary oceanographic geology findings and
interest statement. simulations. This model of explanatory pluralism is being applied
to mental health to facilitate a dialogue between psychiatry and Background and aims.– The term mental is most commonly under-
traditional cultural healers. stood as epiphenomenon of biological or as a reaction of social
Results.– Interaction between traditional cultural healers and men- in the modern biopsychological model of mental disorders. This
tal health professionals revealed an overlapping theory of mind. For poses low efficiency of diagnostic criteria – reductionism (biolo-
the indigenous practitioners, mind was seen as a swarm of stories gization) or psychologization (moralization). By mental disorders in
surrounding the body with each swarm containing a spark of the this essay, we mean endogenous diseases (schizophrenia, bipolar
being who told that story. For the European derived providers, the affective disorder).
closest theory was that of Hubert Hermans’ dialogical self-theory Aims.– To reveal the reality of mental processes as peculiar non-
in which each storyteller is conceptualized as an I-position with the material substrate of entire mental activity in health and diseases.
existence of multiple I-positions and meta-narrators. Methods.– The analysis of humanitarian-anthropological concepts
Conclusions.– Two-eyed seeing allowed a rich dialogue between was carried out.
European-derived practitioners and indigenous people that Results.– Objectives are answered by the “Natural semantic met-
enabled each to appreciate the other’s perspectives, leading to alanguage” developed by the Polish linguist Anna Wierzbicka. It
greater cooperation and collaborative treatment. includes the language model of a person. The verbs to see, to hear,
Disclosure of interest.– The authors have not supplied a conflict of to feel, to think, to do, etc. are not only lexical units, but also states of
interest statement. mind and experiences appropriate and priori clear to everyone. In
the course of increasing complexity of mentality and its reflexive
activity, in particular, their interpretation was carried out; there-
E-PP0831 fore, psychological categories of emotions, thinking, will, etc. were
Psychopathology through created. The words to live and to die can be used to estimate the
evolutionary approach: another forms of activity of these categories, as well as the possibility of
their distortion, weakening or disintegration.
round of the dialectic spiral Conclusions.– The language model of a person shows the reality of
E. Molchanova1* , R. Tsoy2 , I. Sim Molchanova1
1 mental processes and possibility of their disorganization, it warns
American University in Central Asia, Psychology, Bishkek,
a psychiatrist against confusion of biological with mental or social.
Kyrgyzstan; 2 Kyrgyz State Medical Academy, Psychiatry, Bishkek,
Kyrgyzstan
Background and aims.– The aim of the present review lies in multi- E-PP0833
dimensional research of a concept of evolutionary psychiatry and
its significance for understanding the role of mental disorders in
Road less travelled! a study to explore
survival and adaptation of human beings. the relationship between depression,
Methods.– 126 articles and scientific reports were selected accord- religiosity and locus of control in post
ing to criterias for analysis of the evolutionary role of different partum patients in indian tertiary
symptoms of mental disorders. The criterias were: (1) evolution- care hospital
ary approach as a main theoretical basis of an article/report; D. Singh1* , P. Verma2
(2) one or more mental disorders are explained in terms of 1 BJ Govt Medical College and Sassoon Hospital, Pune, Dept of
historical/evolutionary/philosophical approaches; (3) theoretical Psychiatry, Pune, India; 2 Govt Medical Colg Yavatmal, Psychiatry,
discussions are illustrated by clinical examples; (4) high h-index Yavatmal, India
of the author. * Corresponding author.
Results.– Authors confirm a relevance of evolutionary approach and
propose to add historical and synthetic backgrounds in research Background and aims.– Indians are considered more religious as
in the field of mental health. According to evolutionary approach, compared to their first world country mates. With poor obstetric
mental disorders might be considered as normal in the past and services and high foeticide rate in the country, the prevalence of
as pathology in present. This perspective of mental disorders post partum depression is quite high and is an area of concern.
decreases probability that patients would be stigmatized, mak- Religiosity at times may act as a buffer and help in coping from
ing them from “just mentally ill” to “those, who helped humanity depressive states.
survive as species in the past”. In this context, it underlines a sig- Aims.– This study aims to assess the prevalence of depression and
nificance of each individual, whether he/she experiences a mental its relationship with religiosity and locus of control in post partum
disorder or does not. patients admitted in a tertiary care centre and hospital.
Conclusions.– Authors consider mental disorders as a side effect of Methods.– After ethics committee approval 174 post partum
complicated process of human adaptation as biological species to patients admitted in obstetric and gynecology ward were included
constantly changing conditions of dangerous environment. Some in the study. Self-reported semi-structured questionnaire which
specific behaviors that now coded as symptoms of mental disorders included details about socio-demographic profile, Edinburgh post-
in international classifications of diseases were necessary qualities natal depression scale, Hamilton depression rating scale, Duke
for survival of humanity, at the expense of some individuals, they University Religion Index (DUREL) and Multidimensional Health
had led to the development of all human kind. Locus of Control (MHLC) were administered after written informed
Disclosure of interest.– The authors have not supplied a conflict of consent. Data was then analyzed statistically.
interest statement. Results.– Post partum depression was seen in 34 out of 174 par-
ticipating patients admitted in obstetric and gynecology ward. Of
the participants, significantly more prevalence of depression was
E-PP0832
seen in younger age group. Depression was seen to be negatively
The language model of a person as the correlated with religiosity as well as internal locus of control, that
fundamentals of clinical psychiatry is more the depression less is the religiosity and less is the internal
D. Radionov* , B. Voskresenskiy locus of control.
Pirogov Russian National Research Medical University, Department of Conclusions.– This study helps us in understanding that religios-
Psychiatry and Medical Psychology, Moscow, Russia ity can act as buffer and hence a coping mechanism in patients
with depression. In a developing country like India, where religious
practices are given paramount importance, this can help in early purpose of developing the human experience in the surrounding
intervention. universe.
Disclosure of interest.– The authors have not supplied a conflict of Results.– During life, human beings exist in a continuum, as organ-
interest statement. isms that develop and satisfy their needs within society. This
dialectic between the self, existence and environment does not nec-
essarily imply human beings are aware of their existence. Thus,
E-PP0834 the irreducible phenomenon of becoming conscious is achieved by
Vicious circle of disruptive behavior: having contact with our own corporality, and our being in rela-
priming effects of binge eating on tion to the universe. As a result, we experience and interpret our
existence again towards new interactions with the external world,
impulsivity in the five-choice serial
interpersonal relations, and our inner self.
reaction time task (5-CSRTT) Conclusions.– Conscious experience is an active phenomenon, that
D. Wincewicz1* , J. Price2,3 develops intuitive and reflexively, such as in the first phenomeno-
1 Independent Public Mental Healthcare Centre, Department of Old logical reduction, where psychic content and the theory are hold in
Age Psychiatry, Choroszcz, Poland; 2 University of Oxford, Faculty of parentheses, thus transcending the own psyche.
Law, Oxford, United Kingdom; 3 Leiden University Law School, Disclosure of interest.– The authors have not supplied a conflict of
Metajuridica, Leiden, The Netherlands interest statement.
Background and aims.– Goal-directed behavior derives from cogni-

tive control where alternative courses of action and thoughts have E-Poster Presentation: Posttraumatic Stress
to be inhibited. Our understanding of brain function, where intellect
controls passions and impulses by way of the will, is heavily influ-
Disorder
enced, in a philosophical and an interpretive context, by various
elements of Plato’s and of Aristotle’s moral psychology. In psychia-
try, a similar concept of deficient inhibitory processes also has been E-PP0836
adopted to describe psychopathology of impulse control disorders. Work place aggression in context of
The transition from goal-directed to habit-based impulsivity is ptsd - a case report
a problem addressed by this study. Our insight into behavioral A. Albassam1* , L. Gonzalez2
assessment of cognitive control is based on objective labora- 1 Bronxcare Health System, Psychiatry, New York, USA; 2 James J.
tory tasks of response inhibition that have been implemented for Peters VA Medical Center, Psychiatry, New York, USA
humans and rodents with relatively few qualitative differences. * Corresponding author.
Methods.– Male Wistar rats (WAG/Amk) were randomly assigned

to two different feeding schedules (1x/d vs 3x/d) and trained to Background and aims.– Published literature over the past decades
5-CSRTT until achieving target parameters. Single food delivery, has revealed that veterans’ posttraumatic stress disorder (PTSD),
referred to as binge, was associated with competitive feeding inter- following exposures to death of fellow servicemen, affects veter-
actions and reduced feeding time. Completed training was followed ans’ capability to return to the civilian workplace. Recent literature
by test sessions performed on three consecutive days. estimates that 14% of veterans deployed to Iraq and Afghanistan
Results.– There was little to no effect of binge eating behavior on exhibited symptoms of PTSD. DSM-5 has directly linked PTSD to
rats’ performance in the 5-CSRTT. All the rats completed training at violence, indicating that some individuals with PTSD may be quick
a similar rate. While tested on target parameters there were no dif- tempered and may even engage in aggressive, verbal and/or phys-
ferences between means of correct responses, incorrect responses, ical behavior with little or no provocation.
omissions, accuracy, and perseverations. The exceptions were stat- Methods.– we present a case of a veteran who served in Afghanistan.
ically significant increases of premature and of time out responses He witnessed many other servicemen being killed. This has left a
with reduced latency to collect reward. All associated with binge deep impact on his ability to cope with the challenges of daily living.
eating. Results.– He displayed acts of aggression manifested by destruc-
Conclusions.– Impulsivity is not a fully intrinsic but at least partially tion of property, threatening behavior and physically assaulting
acquired disposition. coworkers. This was exacerbated by feelings of shame and
Disclosure of interest.– The authors have not supplied a conflict of anger, alienation and dissociative states. Additionally, the patient
interest statement. indulged himself in cannabis use and energy drink binging which
further aggravated his symptoms.
Conclusions.– This case aims to promote increased responsiveness
E-PP0835 to the needs of veterans suffering from PTSD, and provide suitable
Our conscious experience treatment recommendations, especially for that marginal number
J. Saavedra1 , C. Zarate2* of cases in which the potential for aggressive behavior exists.
1 Universidad San Sebastián, Medicine, Santiago, Chile; 2 Clinica Disclosure of interest.– The authors have not supplied a conflict of
Psiquiátrica Universitaria, Psychiatry, Santiago, Chile interest statement.
Background and aims.– Human beings exist as long as they interact E-PP0837
with their environment. Existence is meaningful and transcends the Efficacy of MDMA-assisted
self in an irreducible experience through the interaction I-the self; psychotherapy for post-traumatic
I-the other. Humans confront the necessity of giving sense to their
stress disorder: systematic review and
existence, configuring and adapting their own history. Past expe-
riences, act as background for the current experience and the next meta-analysis
ones to come. Objective:elucidate the configuration of existence A. Bahji* , E. Hawken, A. Forsyth, D. Groll
through the interaction of I-the self; I-the other through ontology. Queen’s University, Psychiatry, Kingston, Canada
Methods.– Analyzing the conscious experience from an occiden-
tal, oriental and philosophical vision, perspective in an attempt of
coming together poles objected in the vacuity of the TAO; with the
Background and aims.– Post-traumatic Stress Disorder (PTSD) is PTE exposures and operational stress injuries (OSIs) such as PTSD,
a complex mental disorder that involves multiple domains of Depression, Anxiety Disorders, Disorder, and Alcohol Use Disorder.
sustained psychopathology following a significant traumatic expe- Conclusions.– For Federal correctional workers, the most disturbing
rience. Despite the range of therapies to treat PTSD, response to PTE exposures were related to violent death and physical assault.
antidepressants is limited. A growing body of clinical research Given PTE exposure prevalence, and the association with OSIs, pol-
suggests the efficacy of 3,4-methylenedioxymethamphetamine icy makers should ensure evidence-based mental health resources
(MDMA)-assisted psychotherapy in individuals with treatment- are readily available for correctional workers.
refractory PTSD. In this systematic review and meta-analysis, the Disclosure of interest.– The authors have not supplied a conflict of
efficacy of MDMA-assisted psychotherapy for PTSD is explored. interest statement.
Methods.– Relevant randomized controlled trials were identified
from a systematic search of five online databases. Five studies were
included in this meta-analysis. Statistical analyses were conducted E-PP0839
using fixed- and random-effects meta-analysis using Review Man- Mental disorder symptoms among
ager 5.3. public safety personnel in Canada
Results.– The overall response rate to PTSD was 59% (n = 52/88, and A. Bahji1* , R. Ricciardelli2 , N. Carleton3 , D. Groll1
the risk of non-response was significantly higher in the control 1 Queen’s University, Department of Psychiatry, Kingston, Canada; 2
group (RR = 0.29, 95% CI: 0.15, 0.57), indicating higher efficacy in Memorial University of Newfoundland, Department of Sociology, St
the MDMA group (Figure 1). The standardized mean difference in John’s, Canada; 3 University of Regina, Department of Psychology,
PTSD scores following treatment was 0.86 (95% CI: 0.29, 1.42), indi- Regina, Canada
cating a large effect size. * Corresponding author.
Background and aims.– Canadian public safety personnel (PSP; e.g.,

correctional workers, dispatchers, firefighters, paramedics, police
officers) are exposed to potentially traumatic events as a function
of their work. Such exposures contribute to the risk of develop-
ing clinically significant symptoms related to mental disorders. The
current study was designed to provide estimates of mental disorder
symptom frequencies and severities for Canadian PSP.
Methods.– An online survey was made available in English or French
Figure 1. Efficacy in the MDMA group. from September 2016 to January 2017. The survey assessed cur-
rent symptoms, and participation was solicited from national PSP
Conclusions.– MDMA-assisted psychotherapy is an effective, safe, agencies and advocacy groups. Estimates were derived using well-
and powerful treatment for chronic, treatment-refractory PTSD. validated screening measures.
Disclosure of interest.– The authors have not supplied a conflict of Results.– There were 5813 participants (32.5% women) who were
interest statement. grouped into 6 categories (i.e., call center operators/ dispatch-
ers, correctional workers, firefighters, municipal/provincial police,
paramedics, Royal Canadian Mounted Police). Substantial propor-
E-PP0838
tions of participants reported current symptoms consistent with
Mental disorder symptoms among 1 (i.e., 15.1%) or more (i.e., 26.7%) mental disorders based on the
correctional workers in Canada screening measures. There were significant differences across PSP
A. Bahji1* , R. Ricciardelli2 , N. Carleton3 , D. Groll1 categories with respect to proportions screening positive based
1 Queen’s University, Department of Psychiatry, Kingston, Canada; 2 on each measure.
Memorial University of Newfoundland, Department of Sociology, St Conclusions.– The estimated proportion of PSP reporting current
John’s, Canada; 3 University of Regina, Department of Psychology, symptom clusters consistent with 1 or more mental disorders
Regina, Canada appears higher than previously published estimates for the general
population; however, direct comparisons are impossible because of
methodological differences. The available data suggest that Cana-
Background and aims.– Correctional workers are regularly exposed dian PSP experience substantial and heterogeneous difficulties
to potentially traumatic events (PTEs). Such exposures increase risk with mental health and underscore the need for a rigorous epi-
for mental disorders involving substantial personal and social costs. demiologic study and category-specific solutions.
Unfortunately, available data on exposure to PTEs and associations Disclosure of interest.– The authors have not supplied a conflict of
with mental disorders in Canadian correctional workers remains interest statement.
sparse. The current research was designed to provide estimates of
the frequencies of PTE exposure within Federal correctional work-
ers and symptoms of mental health disorders. E-PP0840
Methods.– The data for the current study were collected as part of
Gender differences in posttraumatic
a larger study, using a web-based self-report survey made avail-
able to participants in English or French. The survey included stress disorder (PTSD)
established self-report measures for exposures to PTEs and mental S. Bise1* , G. Sulejmanpasic2 , I. Zukic3
1 Psychiatric Hospital, Women Department, Sarajevo, Bosnia,
disorder symptoms.
Results.– 1308 Federal correctional workers (43.3% male) from Herzegovina; 2 Clinical Center University of Sarajevo, Psychiatric
across Canada responded and reported exposures to 16 PTE types Clinic, Urgent Psychiatry, Sarajevo, Bosnia, Herzegovina; 3 Cantonal
(M = 9.88, SD = 3.88). 88.7% reported being exposed to physical hospital, Internal Medicine with Hemodialysis, Zenica, Bosnia,
assault, 85.6% to sudden violent death, 80.6% to sudden accidental Herzegovina
deaths, and 78.8% to assault with a weapon. When asked to iden-
tify their worst traumatic experience, 24.0% reported exposure to Background and aims.– There are gender differences in the type of
sudden violent death, while ‘physical assault’ was ranked highest trauma exposure, presentation of illness, and comorbidities. Some
by 13.0%. There were statistically significant relationships between of these differences are clearly societal and nonbiologically based,
but it is also clear that the biologic systems altered in PTSD may
modulate or be modulated by sex hormones. Cortisol is the final

mediator of the hypothalamic/adrenal/pituitary (HPA) response,
and there is an elevation of cortisol in the normal stress response.
Individuals with PTSD have low circulating levels of cortisol. Dif-
ferent types of traumas carry different risks for the development of
PTSD, and there are also gender differences.
To examine gender differences in patients with PTSD.
Methods.– Study included 22 patients. Statistical analysis was per-
formed.
Results.– Among patients were 12 man and 10 women. Lifetime
prevalence of traumatic events was slightly higher in men than
in women. The risk for PTSD following traumatic experiences was
higher in women than in men. This gender difference was primarily
due to women’s greater risk of PTSD following events that involved
assaultive violence. Women are more likely to have symptoms of
numbing and avoidance and men are more likely to have the associ-
ated features of irritability and impulsiveness. Men are more likely
to have comorbid substance use disorders and women are more
likely to have comorbid mood and anxiety disorders. Duration of
PTSD was longer in women than in men.
Conclusions.– There are gender differences in the prevalence and
comorbidity presentation in PTSD in patients with PTSD. There
are difference in the use therapy based on gender and comorbid
diseases.
interest statement.
E-PP0841
Association between social anxiety
disorder and posttraumatic stress
disorder among a youth sample in
lithuania
E. Kazlauskas* , M. Kvedaraite, P. Zelviene
Vilnius University, Center for Psychotraumatology, Vilnius, Lithuania
Background and aims.– Social anxiety disorder (SAD) is prevalent

among youth during emerging adulthood and are highly comor-
bid with other mental disorders, including posttraumatic stress
disorder (PTSD). However, there is a lack of studies of comorbid-
ity studies of anxiety and fear related disorders and stress-related
disorders. The aim of this study was to assess prevalence of SAD
and PTSD in the Lithuanian youth sample, and explore associations
among SAD and PTSD symptoms. E-PP0843
Methods.– In total 590 undergraduate students of whom 67.6% were Features of stress response in military
women aged 20 years on average participated in this study. The actions participants with eye trauma
Social Phobia Inventory (SPIN) was used to measure social anxiety
and partial loss of vision
disorder symptoms. The Impact of Event Scale – Revised (IES-R)
I. Leshchyna1*, H. Kozhyna1, M. Markova1, R. Abdrjahimov2, T.
was used to measure PTSD symptoms.
Abdrjahimova3, V. Koshchii1, O. Platyniuk1
Results.– 16.1% of all participants were identified as having a proba- 1 Kharkiv National Medical University, Psychiatry- Narcology and
ble SAD diagnosis. 67.5% participants reported exposure to at least Medical Psychology, Kharkiv, Ukraine; 2 Kiev Clinical Hospital No. 2
one life-time potentially traumatic event. Prevalence of probable on a Railway Transportation, Ophthalmology, Kyiv, Ukraine; 3
PTSD was 17.5%. Life-time trauma exposure was not associated National Medical University, Medical Psychology, Psychosomatic
with SAD symptoms. SAD symptoms were correlated with PTSD Medicine and Psychotherapy, Kyiv, Ukraine
symptoms. 32.2% of participants with SAD were also identified as * Corresponding author.
having PTSD.
Conclusions.– We found high comorbidity of SAD and PTSD in a Background and aims.– In the structure of modern military injuries,
youth sample. These findings should be addressed in clinical prac- traumas of the visual organ occupy the second place by frequency.
tice in providing healthcare for young adults. Further studies are In Ukraine, by 2017, in the structure of ophthalmologic injuries as a
needed to explore comorbidity of social anxiety disorder with other result of a battle trauma, 52% are fragmental and other mechanical
mental disorders. damages, which were not accompanied by massive craniocerebral
Disclosure of interest.– The authors have not supplied a conflict of trauma. Purpose. Studying the peculiarities of stress response and
interest statement. its role in development of psychological maladaptation and signs of
post-traumatic stress disorder in military actions participants with E-PP0845

eye trauma and partial loss of vision. Differences in symptoms of insomnia
Methods.– The research was carried out by clinical-psychological
between patients with PTSD and
and psychodiagnostic methods. 216 people were examined.157 of
them participated in military actions,102 got battle eye traumas
complex PTSD
with partial loss of vision. The comparison group: 59 people with M. Milanovic1* , D. Britvic2 , N. Pleic3 , D. Kirigin3 , T. Roca3 , H.
partial loss of vision due to domestic eye traumas. Tomljanovic3 , G.M. Slavich4
1 Dr, Department of Psychiatry- Clinical Hospital Split, Split, Croatia;
Results.– Eye trauma with partial loss of vision in military actions 2 Prof Dr, Department of Psychiatry, Clinical Hospital Split, Split,
participants on the background of psychological maladaptation and
signs of PTSD is accompanied by the development of state of frustra- Croatia; 3 Prof, Department of Psychiatry Clinical hospital Split, Split,
tion and severe neurotic stress response. The sources are personal Croatia; 4 Associate prof, Laboratory for Stress Assessment and
limitations that arise from the trauma and lack of support from Research, Cousins Center for PsychoneuroimmunologyUniversity of
society, environment. The basis of the development of severe stress California, Los Angeles, USA
state in response to frustration are the phenomena of mental mal-
adaptation. In its progress, maladaptation leads to neuroticism and Background and aims.– According to recent data up to 80–90 percent
somatization of the process against the background of preservation of patients with PTSD experience insomnia and comorbid sleep-
of general phenomena of maladaptation. ing disturbances. Patients with sleep disorders are in higher risk
Conclusions.– This indicates the need to apply differentiated of functional disability. Also their existing PTSD symptoms may
approach to neutralization of various sources of mechanisms of exacerbate insomnia.
combined pathological process in planning measures for psycho- The aim of our study is to compare and identify differences between
logical correction of this category of victims. insomnia symptoms among patients with PTSD and Complex PTSD
Disclosure of interest.– The authors have not supplied a conflict of and to better understand Complex PTSD.
interest statement. Methods.– This study among 100 patients with PTSD and Complex
PTSD is a part of other project about correlation of stress exposure,
presence of PTSD symptoms and inflammatory markers connected
E-PP0844
with some somatic diseases.
Posttraumatic stress and joint Diagnosis of Complex PTSD based on results of: “Interna-
hypermobility syndrome among tional Trauma Questionnaire”. Insomnia symptoms measured by:
children and adolescents in selected “Insomnia Severity Index”.
schools of Nepal after the 2015 Results.– Reliving the trauma through “flash backs” and nightmares
may lead to hyper-arousal, avoiding going to bed and worsening
earthquakes insomnia symptoms in patients with Complex PTSD.
C.D. Llach1* , A. Bulbena2 , G. Pailhez2 , C. Conejo3 , P.M. Singh4
1 So we expect more severe symptoms of insomnia in these patients.
Hospital Clinic i Provincial de Barcelona, Psychiatry, Barcelona,
Conclusions.– Current PTSD diagnosis often does not fully capture
Spain; 2 Hospital del Mar, Psychiatry, Barcelona, Spain; 3 Fundacio
the severity of psychological harm that occurs with prolonged,
Catalunya La Pedrera, Area of Knowledge and Research, Barcelona,
repeated trauma, such as:changes in self-concept and adaptation
Spain; 4 Nepal Medical College and Teaching Hospital, Psychiatry,
skills, addictive behaviour, self-mutilation. ICD 11 identifies this
Kathmandu, Nepal
* Corresponding author. condition as a separate diagnosis that includes PTSD with person-
ality changes and named it: “Complex PTSD”.
Background and aims.– A substantial body of literature has recently Complex PTSD is still often misdiagnosed as personality disorder
addressed the connection between the exposition to a catastrophic or unrecognized. We hope this study will help to improve this.
event such an earthquake and the development of posttraumatic Disclosure of interest.– The authors have not supplied a conflict of
stress disorder (PTSD), especially in the vulnerable stratum of chil- interest statement.
dren and adolescents. However, little is known about its prevalence
and risk factors. This study was undertaken 3–4 months after the
E-PP0846
2015 earthquakes in Nepal, with the aim of providing new evi-
dence to the field and documenting the role of a new potential Multimodal-psychological
predisposing factor: the joint hypermobility syndrome (JHS). rehabilitation combatants in Ukraine
Methods.– 934 subjects from three different regions of the country, B. Mykhaylov* , O. Kudinova
aged 8–18 years were assessed with self-completed question- Kharkiv Medical Academy of Postgraduate Education, Psychotherapy,
naires in a school-based cross sectional investigation. PTSD, as the Kharkiv, Ukraine
response variable, was analyzed taking into account three sub- * Corresponding author.
dimensions: the severity of symptoms, the severity of impairment,

and both taken together. Background and aims.– For the period of 2014–2017 years, the
Results.– The severity of PTSD in its three sub-dimensions was specialists of the department of psychotherapy of the KMAPE con-
strongly predicted by the distance to the epicenter. Girls showed a ducted consultative-diagnostic, medical and psycho-rehabilitation
higher affectation in the severity of symptoms field, but conversely assistance to 2,387 demobilized participants of the ATO, including
a lower perturbation in the daily functioning dimension. Younger on the basis of the Clinical sanatorium “Resort Berezovsky mineral
children reported a more severe functional impairment. JHS and waters” - 650 persons, in the “Regional hospital of war veterans” -
non-JHS groups statistically differ in the prevalence of PTSD dual 130 persons, as a part of visiting polyprofessional brigades on the
affectation, being the first more prone to suffer from it. bases of the Central district hospitals of the Kharkiv region - 1607
Conclusions.– The influence of the analyzed predisposing factors in persons. The principle of the formation of the psychological reha-
the development of PTSD is discussed. Especially, the connection bilitation of persons involved in the implementation of the ATO
between JHS and PTSD is described with reference to the neuro- should be the demarcation of contingents, on which depends the
connective phenotype. It might be useful to consider the role of mobilization route of the participants of the ATO. The first group is
each variable when planning a mass intervention after a disaster. demobilized persons whose combat stress did not lead to mental
Disclosure of interest.– The authors have not supplied a conflict of and behavioral disorders that reach a painful level.
interest statement.
Methods.– We have recommended psychotherapeutic actions: E-PP0848

1. Psycho-education as the basis of psychotherapy / psycho- A prospective study of the
correction; 2. Trauma-focused cognitive-behavioral therapy; 3.
neurophysiological predicitive
Desensitization and study of eye movements; 4. Establish a thera-
peutic alliance. How desirable actions are recommended: 1. Stress
markers for posttramatic stress
management; 2. Family psychotherapy. disorder in sexual assault survivors
Results.– Carrying out psychological rehabilitation by us of 2,387 S.M. Park1,2* , J.S. Choi1,3 , H.Y. Jung1,2,3
1 SMG-SNU Boramae Medical Center, Psychiatry, Seoul, Republic of
demobilized participants of the ATO allowed us to achieve a signif-
icant increase in the level of psychological and social functioning Korea; 2 Seoul National University College of Medicine, Clinical
in 73% of persons, a slight increase in 8%. Medical Sciences, Seoul, Republic of Korea; 3 Seoul National
Conclusions.– The principle of the formation of the psychological University College of Medicine, Psychiatry and Behavioral Science
rehabilitation of persons involved in the implementation of the ATO and Institute of Human Behavioral Medicine, Seoul, Republic of Korea
should be the demarcation of contingents, on which depends the
mobilization route of the participants of the ATO.
Background and aims.– To prevent the chronicization of post-
traumatic stress disorder (PTSD) and other mental disorders, it is
interest statement.
important to evaluation and intervention of sexual assaults sur-
vivor’s mental health at an early stage. This study aimed to find
E-PP0847 out the prognostic makers for PTSD measuring clinical symptoms,
electroencephalograph (EEG) features, and neurocognitive func-
Validation of the korean version of tion immediately after a sexual assault.
the clinician-administered PTSD scale Methods.– Twenty-seven female sexual assault survivors within 4
for DSM-5 (CAPS-5) weeks after the event were included. Age-matched depression con-
J.E. Park1* , S.H. Yoo1 , W.H. Kim2 , Y.E. Jung3 , D. Roh4 trols (DCs, n = 23) and healthy controls (HCs, n = 25) were enrolled.
1 Keyo Hospital, Department of Psychiatry, Uiwang, Republic of Resting-state EEG, executive function and clinical measurement
Korea; 2 Inha University Hospital, Department of Psychiatry, Incheon, were exam within 4 weeks of sexual assault at baseline. Ten of sur-
Republic of Korea; 3 School of Medicine Jeju National University, vivors were classified as PTSD (PTSD+) and 10 as sub-clinical PTSD
Department of Psychiatry, Jeju, Republic of Korea; 4 Hallym University (PTSD-) by Clinician-Administered PTSD Scale (CAPS) administered
Chuncheon Sacred Heart Hospital, Hallym University College of after three months of assaults.
Medicine, Department of Psychiatry, Chuncheon, Republic of Korea Results.– Both survivors with PTSD+ and PTSD- showed higher rate
of errors on set-shift than DCs and HCs and and those with PTSD+
and PTSD- had lower level of planning than HCs at baseline. For
Background and aims.– This study was aimed to develop and vali- EEG, both those with PTSD+ and DCs showed heightened spectral
date the Korean version of Clinician-Administered PTSD Scale for power in delta, beta, high beta bands compared to HCs, while those
DSM-5 (K-CAPS-5). with PTSD- did not. In addition, those with PTSD+ had decreased
Methods.– Subjects were recruited from 8 medical institutions in functional efficacy, small-world network, in theta band than HCs.
South Korea From February 2016 until March 2018. Among total Absolute delta power of survivors at baseline was associated with
247 subjects, 71 subjects with PTSD, 74 subjects with mood dis- 3 month later CAPS-avoidance.
order or anxiety disorder as a psychiatric control group, and 99 Conclusions.– Heightened EEG spectral power and decreased net-
subjects as a healthy control group, which were diagnosed by the work efficacy of sexual assault survivors at the early stage might be
structured clinical interview for DSM-5-research version (SCID-5- prognostic markers for PTSD.
RV). The Beck Depression Inventory-II (BDI-II), the Beck Anxiety Disclosure of interest.– The authors have not supplied a conflict of
Inventory (BAI), the Impact of Event Scale-Revised (IES-R), and the interest statement.
Spielberger State Trait Anxiety Inventory (STAI) were also assessed.
Results.– Internal consistency for the K-CAPS-5 total score was 0.92.
Alpha coefficients for the intrusion, avoidance, cognition/mood, E-PP0849
and arousal/reactivity were 0.83, 0.71, 0.82, and 0.75, respectively.
Post-traumatic stress disorder in
The test-retest reliability was also determined to be 0.91. The
total scores ± standard error (SE) of K-CAPS-5 in the PTSD group, mothers of premature infants
the psychiatric controls and normal controls were 33.03 ± 1.07, A. Ben Hamouda1 , S. Bourgou1 , R. Khemakhem1 , L. Sahli1* , M.
18.00 ± 9.79, and 6.18 ± 5.86, respectively. PTSD and dissocia- Lamouchi2 , N. Siala2 , O. Azabi2 , A. Belhadj1
1 Mongi Slim Hospital, Child and Adolescent Psychiatry, Marsa,
tive subtype diagnoses were almost perfect agreement (k = 0.893,
k = 0.839, respectively). The total K-CAPS-5 score was correlated Tunisia; 2 Mongi Slim Hospital, Pediatrics and Neonatology, Marsa,
with BDI (r = 0.58, p < 0.001), BAI (r = 0.67, p < 0.001), IES-R (r = 0.78, Tunisia
p < 0.001), and STAI-T (r = 0.37, P = 0.003). The highest diagnostic
agreement was found at a total severity score of 24, where the Background and aims.– The aim of this study was to evaluate the
sensitivity and specificity were 88.73% and 93.18%, respectively. symptoms of post-traumatic stress disorder (PTSD) in mothers of
Conclusions.– The Korean version of CAPS-5 showed good psy- premature infants and in those of full-term ones.
chometric properties and may be used as a reliable and valid Methods.– A case-control study among mothers of infants born dur-
instrument to diagnose and assess PTSD according to DSM-5. ing the year 2017 was conducted in the Pediatrics and Neonatology
Disclosure of interest.– The authors have not supplied a conflict of Department of Mongi Slim Hospital (Tunisia). The symptoms of
interest statement. the post-traumatic stress disorder were evaluated by the Arabic
version of the Impact of Event Scale (IES). Thirty-three mothers of
preterm infants were included in the study (n = 33). Their responses
were compared with a control group of mothers of full-term infants
(n = 25).
Results.–
- Group 1: mothers of preterm infants (n = 33). Maternal mean age:
33,55 ± 5,13 years old. Two-thirds of them had caesarian delivery.
Mean gestational age: 32,14 ± 1,92 weeks. Average hospital stay 1 Southeast University, School of Information Science and
in Neonatology: 19,18 ± 14,3 days. Fifty-four point five percent Engineering, Nanjing, China; 2 Southeast University, Shing-Tung Yau
of the mothers had pronounced symptoms of PTSD. Mean IES- Center, Nanjing, China; 3 Southeast University, Department of
score: 36,79 ± 17. Mean Intrusion Subscale: 11,42 ± 5,88. Mean Psychosomatics and Psychiatry, ZhongDa Hospital- School of
Avoidance Subscale: 11,79 ± 5,79. Mean Hyperarousal Subscale: Medicine, Nanjing, China; 4 Capital Medical University, The National
12,06 ± 5,97. Clinical Research Center for Mental Disorders & Beijing Key
- Group 2: mothers of full term infants (n = 25). Maternal mean age: Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing,
27,52 ± 3,72 years old. All mothers had normal delivery. Mean China; 5 Capital Medical University, Advanced Innovation Center for
gestational age: 38,76 ± 0,81 weeks. Mean IES-score: 1,84 ± 2,28. Human Brain Protection, Beijing, China
Mean Intrusion Subscale: 0,48 ± 0,77. Mean Avoidance Subscale: * Corresponding author.
0,48 ± 0,77. Mean Hyperarousal Subscale: 1 ± 0,91. The occur-

rence of PTSD symptoms was increased in mothers of preterm Background and aims.– It is believed that depression is caused by
infants compared with the control group (p < 0,001). a psychological reaction to social and psychological stress factors.
Conclusions.– Posttraumatic stress symptoms related to premature Moreover, 5-HTR1A receptors are involved in the pathogenesis of
childbirth need more attention from health practitioners in the field affective disorders and associated with the onset of post-stroke
of pregnancy, delivery and postpartum care. depression (PSD). The purpose of this study is to investigate the
Disclosure of interest.– The authors have not supplied a conflict of interaction mechanism between the polymorphisms of 5-HTR1A
interest statement. and social psychological factors in Chinese patients with PSD.
Methods.– A total of 252 subjects, including 121 PSD patients and
131 healthy controls, underwent a collection of demographic data,
E-PP0850 14 social psychological scales and tested 4 single nucleotide vari-
Efficacy of pre-reactivation ants corresponding to the 5-HTR1A gene. Firstly, the decision tree
method is used for dimensionality reduction and classification.
propranolol in syrian refugee children
Then, based on the Bayesian network, the interaction mechanism of
with ptsd in war context 5-HTR1A–social psychological factors –PSD is constructed by data
S. Thierrée* , W. El Hage driven. The model was scored using the K2 algorithm to obtain the
University of Tours France, Inserm, UMR 1253, Ibrain, Tours, France best structure.
Results.– The study shows that, through the decision tree approach,
social psychological factors include EPQ-N, SSRS, TAS, TEPS, SHARPS
and RANKIN scales. By constructing the interaction mechanism,
Introduction.– Post-traumatic stress disorder (PTSD) is the most
it was found that SNV09688, SNV25756 and SNV33218 in the 5-
commonly developed mental disorder in the context of war. The
HTR1A gene have interactions, which have a direct influence on
potentiation of exposure therapy by propranolol is a relatively sim-
the occurrence of PSD and social psychological factors. Moreover,
ple and economical therapeutic option that has demonstrated its
social psychological factors played a mediating role in the 5-HTR1A
effectiveness in PTSD adults.
affecting the PSD.
Objectives.– To evaluate the efficacy of trauma reactivation under
Conclusions.– The results further suggest that the occurrence of PSD
the influence of propranolol on reducing PTSD symptoms of Syrian
may be related to the polymorphism of 5-HTR1A and the social
children living in a refugee camp.
psychological factors as a mediating effector, revealing the inter-
Methods.– We implemented an interventional non-controlled open
action mechanism between them, which might be used to predict
label clinical therapeutic trial in a refugee camp on the Syrian
the appearance of PSD.
territory, which evaluated efficacy and safety of our therapeutic
strategy in children. A total of 170 children were screened, and
interest statement.
117 children were enrolled in the study. Each participant received
propranolol 90 minutes before a reactivation session using a per-
sonal traumatic script, daily for 5 consecutive days. We conducted
E-PP0852
a standardized clinical evaluation of anxiety, depression and PTSD
symptoms before, one week after, one and three month after the The impact of the clinical and
treatment. psychological issues in PTSD
Results.– We observed a significant improvement of anxiety, manifestation in breast cancer
depression and PTSD symptoms from pre- to post-treatment patients after successfull surgical
assessments. Clinical improvements were observed since the first
treatment (mastectomy)
week and persisted for 3 months.
A. Vasileva1* , N. Neznanov2 , E. lukoshkina3
Conclusions.– This is the first study to demonstrate the efficacy of 1 V. M. Bekhterev Medical Research Centre for Psychiatry and
pre-reactivation propranolol for PTSD in children, even in the con-
Neurology Russian Federation Ministry of Healthcare, I. I. Mechnikov
text of war. Replication studies in other groups of children are still
North-Wstern State Medical University, Non-Psychotic Disorders
required. Consequently, this therapeutic strategy can facilitate care
Treatment and Psychotherapy, Saint-Petersburg, Russia; 2 V. M.
access to large number of trauma victims.
Bekhterev Medical Research Centre for Psychiatry and Neurology
Russian Federation Ministry of Healthcare, Director, Saint Peterburg,
interest statement.
Russia; 3 Clinic Caduseus, Clinical Psychology, Saint Petersburg,
Russia
E-PP0851
Interaction mechanism between Background and aims.– The results of comparative analysis with
polymorphisms of 5-HTR1A and social the use of the psychodiagnostic tests battery of the breast can-
psychological factors in patients with cer related PTSD symptoms group and the well coped with cancer
related distress group are presented.
post-stroke depression
Methods.– Cancer as a life theratening disease is considered now-
P. Tianci1,2* , Y. Wu1,2 , Y. Yue3 , R. Liu4,5 , L. Wu1,2 , Y. Yuan3 , Q.
days as a possible trigger of the PTSD. At the first stage the patients
Wang1,2
were screened with test and clinical interview for ptsd diagnosis.
Then the group of PTSD breast cancer patients after successful mas- Background and aims.– Impulsivity is defined as “a predisposi-
tectomy was compared with the control group of the well coped tion toward unplanned actions without consideration of negative
patients. The test battery icluded, the impact of traumatic event consequences”. It is associated to many psychiatric disorders. In
scale, G. Ammon Ego-structure test, D. Leontiev resilience test, Type literature, this trait is thought to be elevated in patients with post-
of the internal disease construct test, experience of the close rela- traumatic stress disorder.
tionship test. The aim of this study is to assess the prevalence of impulsivity in
The multiple regression analysis with the score of the ptsd screen- military patients diagnosed with PTSD.
ing scale as dependent variable was preformed for the ptsd patient Methods.– Patients completed forms collecting socio-demographic,
group results allowed to distinguish psycho-social risk factors for clinical and therapeutic data, the PTSD checklist for DSM5 (PCL-5)
breast cancer related PTSD manifestation. and the Barratt impulsiveness scale (BIS-11).
Results.– The main risk factors for PTSD manifestation are domi- Results.– Fifty-nine patients diagnosed with PTSD were assessed in
nance of the destructive ego-functions in the personality profile; this study. The sample was composed by 58 men and one woman.
deficit of the positive basic beliefs about oneself and environment The mean age was 32.85 years. The most represented military rank
determining effective coping with the disease onset; excessive was master corporal in 49%. Fifty one percent of our PTSD patients
autonomy and independence in th close relationships, defining the were in clinical remission and had PCL-5 scores under 33. The mean
decreased outer emotions expression and worries communication impulsivity score of our military group was within the normal limit
and restricted ability to use the social environment as a support of impulsivity at 66.93. High impulsivity trait was found in 44%
source in the face of cancer manifestation. of our sample (BIS-11 > 71). However, there was no correlation
Conclusions.– The study results can be used in the diagnostic of vul- between the impulsivity scores and the PCL-5 scores. The BIS-11
nerable to ptsd manifestation breast cancer patients and should be scores were higher in patients with active PTSD symptoms com-
considered as tpsychotherpaetic tergets in psychosocial intereven- pared to remitted ones, though, this difference was not significant.
tion programs. Conclusions.– High trait impulsivity was found in 44% of our PTSD
Disclosure of interest.– The authors have not supplied a conflict of military patients, however, comparing this proportion with PTSD-
interest statement. free soldiers would help determine whether trait impulsivity is
linked to developing PTSD symptoms.
E-PP0853 interest statement.
Depression in PTSD military patients
O. Zerriaa* , M.W. Krir, W. Kabtni, R. Lansari, A. Baatout, I.
Bouzouita, C. Ben Chikh, H. Elkefi, A. Oumaya E-Poster Presentation: Prevention of Mental
Military Hospital, Psychiatry Department, Tunis, Tunisia
* Corresponding author. Disorders / Substance related and Addictive
disorders IV
Background and aims.– Post-traumatic stress disorder (PTSD) is
frequently comorbid to other psychiatric conditions. Studies has
shown that comorbidities are found in 80% of patients with PTSD. E-PP0855
The most common comorbidity of this disorder is depression. Depression and anxiety screening
The current study aims to assess depression among PTSD military
patients.
among medical students: a
Methods.– Patients completed forms collecting socio-demographic, cross-sectional survey
clinical and therapeutic data: the PTSD checklist for DSM-5 (PCL- B. Atienza-Carbonell1* , V. Balanzà-Martínez2
1 University of Valencia Medical School, Department of Medicine,
5), the Beck depression inventory (BDI) and the short form survey
(SF-12) to assess quality of life. Valencia, Spain; 2 University of Valencia Medical School, CIBERSAM,
Results.– The sample was formed by 59 military patients diagnosed Department of Medicine, Valencia, Spain
with PTSD: 58 men and one woman. The mean age was 32.85
years. Forty-nine per cent of patients had the military rank of chief-
Background and aims.– Medical education is known to be highly
corporal. Fifty one percent of patients were in clinical remission and
demanding for medical students, who in turn are more vulnerable
had PCL-5 scores under 33. Depressive symptoms were present in
to mental health issues than the general population.
80% of our patients: 15% had symptoms of mild depression, 25%
Methods.– A cross-sectional, online survey was conducted in
had moderate depression and 40% had severe depressive symp-
April 2018to evaluate the prevalence of depression and anxiety
toms. Patients with active PTSD symptoms were more likely to be
symptoms among medical students. All students enrolled at the
depressed (p < 0.001) than remitted patients. Quality of life assessed
University of Valencia Medical School were invited to complete
with SF-12 showed that PTSD patients had lower quality of life than
the Beck Depression Inventory (BDI-II) and a short version of the
remitted ones (p = 0.001). A significant association was also found
State and Trait Anxiety Inventory (STAI) questionnaires. Students
between depressive symptoms and lower quality of life (p = 0.042).
participated at their own accord and responses were anonymized.
Conclusions.– The association of depression and PTSD is very com-
Results.– 858 of 2035 students (response rate = 42.2%) completed
mon and it affects the of quality of life. Therefore, clinicians should
the survey. Nearly a third of the sample (29,4%) had consulted at
take it into consideration to ameliorate the prognosis and to adapt
least once with a professional due to mental health issues. Almost
therapeutic measures to both conditions.
a quarter of the students (23,2%) suffered from moderate to severe
depression. 15,8% of students reportedsuicidal ideation. Levels of
interest statement.
depression and anxiety were significantly higher in female than
male students. No significant differences were found in depres-
E-PP0854 sion for each year of studies. Nevertheless, students in second year
showed the highest levels of anxiety-state, which were significantly
Trait impulsivity in PTSD patients
different from fifth and sixth years. Among first-year students, lev-
O. Zerriaa* , M.W. Krir, W. Kabtni, H. Ben Mustapha, A. Baatout, I.
els of anxiety tended to be lower in those receiving peer-student
Bouzouita, C. Ben Cheikh, H. ElKefi, A. Oumaya
mentorship.
Military Hospital, Psychiatry Department, Tunis, Tunisia
* Corresponding author. Conclusions.– Medical student’s mental health may differ by sex
and class year. Medical Schools should develop actions to support
improvement of medical students’ depression and anxiety levels. Methods.– Anthocyanins (RA) were prepared using acidified water
Further studies should be performed in different regions to com- method from the red rose petals according to standard protocol,
pare these results with those other academic environments. dried under pressure. Drosophila melanogaster young male flies (3d
Disclosure of interest.– The authors have not supplied a conflict of old, 50 flies/ group) maintained on a diet enriched with Rose antho-
interest statement. cyanins (0.01–0.05% w/v in medium) were co-challenged with
ferric chloride and sodium nitroprusside separately. Flies were
monitored for behavioural manifestations and terminally for bio-
E-PP0856 chemical index.
Tackling more than fires: the person Results.– RA flies performed better in an open field grid in terms of
behind the professional improved locomotor function as opposed to oxidant groups. RA flies
J.P. Becker1,2* , L. Sales2 , D. Andringa2 , A. Dias3 also demonstrated reduced stress as evidenced with low aggres-
1 University of Coimbra, Faculty of Psychology and Education sion. Flies treated with RA demonstrated modulated redox status
Sciences, Coimbra, Portugal; 2 Centre for Social Studies of the evident from increased thiol levels and reduced hydroperoxides
University of Coimbra, Trauma Centre, Coimbra, Portugal; 3 Utrecht levels in the homogenates. Further, there was induction of hsp70
University, Psychology, Utrecht, Netherlands Antilles levels among Bg9 larvae. Further, RA reduced the Oxidant-induced
* Corresponding author. oxidative stress among flies in a concentration dependent manner.
Conclusions.– Our data from drosophila are suggestive of
Background and aims.– Continuously, society has been affected potent neuro-attenuatory propensity of Rose anthocyanins against
by traumatic events which disturb physical and psychological chemically-induced stress phenotype and biochemical etiology
health of people and communities, such as forest fires that hit among drosophila however studies are warranted for long term
Portugal every year. Recognizing the consequences of the repeated implications.
exposure to potentially traumatic events, the Trauma Center Disclosure of interest.– The authors have not supplied a conflict of
researchers have been discussed intervention strategies for pre- interest statement.
venting traumatic stress among professionals who work in crisis
and catastrophes contexts.
Methods.– Through meetings with professionals who were involved E-PP0858
in the ranging forest fires of 2017, a literature review and the work Cannabis use and the risk of transition
of the main author inside Fire Departments, it was possible to to psychosis in subjects at ultra high
identify the sensitive factors for the development of stress-related
risk for psychosis
pathologies and outline interventions to prevent them.
F. Fekih-Romdhane* , A. Hakiri, M. Cheour
Results.– Although firefighters are considered a high-risk group for
Razi Hospital, Psychiatry Department “Ibn Omrane”, Manouba,
developing PTSD and other psychopathologies, some studies point
Tunisia
out training and experience are protection factors, mentioning low * Corresponding author.
PTSD rates among these professionals. This finding has been cor-
roborated through the authors’ research, which is evidencing that Background and aims.– Cannabis use is widespread among people
more than exposure to traumatic event, the feeling of lack of con- at ultra-high risk (UHR) for psychosis. The causal link as well as
trol is associated with the perception of stress and, consequently, the temporal link between cannabis use and further occurrence of
with adverse reactions as PTSD symptoms. psychosis in UHR people has been the subject of several studies
Conclusions.– In addition to the training, the knowledge about whose results remain inconclusive or discordant in some aspects
traumatic stress, normal reactions after extreme events and of this association.
problem-focused coping strategies seem to be essential for improv- Methods.– We proposed to study, in this paper, the association
ing the ability of professionals to manage their daily work, which between cannabis use and psychosis, in order to describe the role
include to deal with the suffering of communities while leaving of cannabis use in the subsequent development of psychosis at
their own emotions aside. Acknowledging the signs of stress pro- UHR subjects and to discuss the mechanisms that could explain
vides the sense of control in the same way of the training and clear this association.
instructions of missions do it. Results.– Current science data supported an increased risk of transi-
Disclosure of interest.– The authors have not supplied a conflict of tion to psychosis in cannabis users who are genetically predisposed
interest statement. to psychosis. This risk would be even greater in the presence of
a family history of psychosis, in case of a strong use (abuse or
dependence) and an early onset use. The studie emphasized a
E-PP0857 dose-dependent effect of cannabis use. The mechanisms that could
Protective effects of rose explain this link involved cannabis-induced modifications of some
anthocyanins against psychiatric brain structures, a dysregulation of the hypothalamic-pituitary axis
stress among young Drosophila and an alteration of normal neurological development via the endo-
cannabinoid system.
exposed to an oxidant: behavioural
Conclusions.– Cannabis use is a modifiable psychosis risk factor, and
and biochemical indices the ultra-high risk period is an opportunity for prevention and early
G. Chandran* , J.B. Chauhan intervention in order to reduce the risk of transition to psychosis.
PBMMEC- University of Mysore, Lifesciences, Mysuru, India Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
Background and aims.– Anthocyanins, the colored derivatives of
polyphenols, found among fruits, vegetables and flowers. Major
varieties of anthocyanins have been reported from rose petals. Due
to their potential biological in vitro, and no data about the neuro-
protective effects, it was envisaged to test their properties against a
stress phenotype in Drosophila. Also to elucidate the anti-psychotic
stress propensity of rose anthocyanins in drosophila model.
E-PP0859 dissatisfied, 37.93% moderately dissatisfied), job and lack of profes-

Focus groups help us determine the sional realization (55.71% highly dissatisfied, 44.83% moderately
good and bad sides of prevention dissatisfied), and financial conditions (60.34% highly dissatisfied,
39.66% moderately dissatisfied). According to data from the PSM-
programs 25 Scale, the most of IDPs have moderate or high levels of stress
S. Kocijančič1* , V. Švab2 (56.9% and 6.9%, respectively) as well.
1 General Hospital Novo Mesto, Psychiatry, Novo Mesto, Slovenia; 2 Conclusions.– A comparison between the results obtained and data
Faculty of Medicine, University of Ljubljana, Department of from literature demonstrated that the revealed factors could be
Psychiatry, Ljubljana, Slovenia predictors of IDPs’ mental health impairments, and a further mon-
itoring of these factors is needed.
Background and aims.– Antidiscrimination programs are a key part
interest statement.
of mental health prevention. Slovenian medical students of the
project “In reflection” conduct workshops for high-schoolers to
inform them about mental disorders, raise awareness and de-
E-PP0861
stigmatize.
Comparing opinions of the conductors and participants of the anti- Influence of family psychiatric history
discriminatory workshops by exploring the strengths, weaknesses, on the onset of mental disorders in
opportunities and threats (SWOT). the military
Methods.– Focus groups were conducted in the Secondary nursing A. Nassim Ahmed Djaouad* , B. Bensatal, S. Belala
school Ljubljana, where adolescents that had the workshop, were 1 HCA, Algiers University, Algiers, Algeria
randomly selected to participate in the focus group of 12 people. * Corresponding author.
Workshop conductors were from the Faculty of Medicine (Ljubl-

jana) and volunteered to participate in a focus group of 8 people. Background and aims.– The stress in the army plays a preponderant
The focus group was SWOT based, with 2–3 introductory questions role in the occurrence and the expression of mental disorders in the
and an open commentary in the end. predisposed individuals. Family history of mental disorders, like
Results.– Answers were compared from both groups. The positive other risk factors, predisposes some people to developing mental
side of the workshops is its interactivity in which all agreed. The disorders when they are exposed to military-related constraints.
conductors of workshops said the weakest point was that they were Methods.– The main objective of the study is to evaluate the fre-
lacking in numbers, while the biggest problem were uninterested quency of mental disorders justifying hospitalization at the mental
adolescents. Adolescents on the other side said the weakest point health ward of the Army Central Hospital, and to correlate them
is that there is not enough time to take all of it in and it was prob- with the absence or the presence of a family psychiatric history in
lematic for them, especially that the topic is too personal. After the the first degree relatives. The study included 249 hospitalized sol-
workshop, the conductors felt fulfilled, while the adolescents felt diers who underwent a multi-axial evaluation of the DSM-IV-TR.
contemplative about the topic. Their family psychiatric history was researched using a question-
Conclusions.– The focus group showed us that the views of partic- naire witch adapted from Family History Screening.
ipants and conductors are quite different, but both groups agree, Results.– Adjustment disorders are the most common mental dis-
that the strength of the workshop is its interactivity. While at the orders. Mood disorders and psychotic disorders are each found in
same time both groups seem to get something out of the workshop. nearly one-quarter of the subjects in the study. These three cat-
Disclosure of interest.– The authors have not supplied a conflict of egories of disorders represent the main diagnosis in nearly 90% of
interest statement. patients in our cohort. A family psychiatric history is present in 17%
of the patients in the study. Our results showed significant statisti-
cal correlations between psychotic disorders and family psychiatric
E-PP0860 history.
Risk factors for mental health Conclusions.– These results highlight the importance of systemat-
ically searching for family psychiatric history during recruitment
impairments in internally displaced visits, especially for history of psychotic disorder.
persons Disclosure of interest.– The authors have not supplied a conflict of
N. Maruta* , I. Yavdak, T. Panko, S. Kolyadko, G. Kalenska interest statement.
“Institute of Neurology, Psychiatry and Narcology of the NAMS of
Ukraine” SI, Borderline Mental Pathology, Kharkiv, Ukraine
E-PP0862
Background and aims.– According to data from the UN High Com- Burnout syndrome among medical
missioner for Refugees, in Ukraine at the beginning of 2018, there internship from a Brazilian public
were 1,800,000 of internally displaced persons (IDPs) and persons university and the contribution of
affected by military actions on the East of Ukraine. The analysis balint group to its prevention
has suggested that IDPs after changes of their residence continue D.A. Calcides, R. Didou, M. Mendes Júnior, E. Melo, E. Oliva-Costa*
to have difficulties due to social, everyday life, economic, and psy- Federal University of Sergipe, Department of Medicine, Aracaju, Brazil
chological factors. These are predictors for acculturation stress and * Corresponding author.
impairments of IDPs’ mental health. The aim of the study was to
investigate risk factors of mental health impairments in IDPs as Background and aims.– Medical students suffer more stress in the
results of the military conflict on the East of Ukraine. last two years of their undergraduate (Medical Internship), which
Methods.– A questionnaire to investigate social-demographic fac- can lead them to have Burnout Syndrome (BS), a type of occupa-
tors, living conditions, and social and professional positions; the tional stress. Balint Group (BG) participants develop skills to better
PSM-25 Scale to identify levels of stress, as well as mathematical protect themselves from these stressors. We intend to estimate the
statistical methods. BS prevalence and associated factors among medical internship stu-
Results.– 58 IDPs (men – 29.31% and women – 70.69%; mean age dents besides to investigate the BG contribution in its prevention.
43.6 ± 3.4 years old) were interviewed. The results suggests that Methods.– It was conducted a cross-sectional study with Public
IDPs were dissatisfied with their living conditions (62.07% highly University Medical Internship Students of the Aracaju-Sergipe-
Brazil in February/2018. It was applied a structured questionnaire E-PP0864

developed by the authors about socio-demographic data, educa- Circadian rhythm change and the
tional process with BG participation and current psycho-emotional
preventive role of psychoeducation in
experiences besides the Maslach Burnout Inventory/Student Sur-
vey (MBI-SS) for BS screening. It was performed descriptive data
severe mental illness: a case study
analysis, logistic regression and cluster analysis. H. Simião1* , L. Santana1 , N. Moura1 , S. Nascimento2 , R. Carvalho3 ,
Results.– It was participated 184 students (98%), with a mean age J. Gago1,4
1 Centro Hospitalar de Lisboa Ocidental, Psychiatry, Lisbon, Portugal;
of 25.9 ± 3.9 years, of which 54.9% were men. The prevalence of BS 2 Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisbon,
was 10.3% by the three-dimensional criterion and 35.9% by the two-
dimensional criterion (Exhaustion and Cynicism), being higher in Portugal; 3 Centro Hospitalar de Lisboa Norte, Child and Adolescence
those who thought to drop-out of the undergraduate (OR = 2.14), Psychiatry, Lisbon, Portugal; 4 NOVA Medical School, Faculdade de
were dissatisfied with the teaching strategies (OR = 2.67) and its Ciências Médicas, Lisbon, Portugal
performance (OR = 2.64). The variables associated to BS allowed
the individuals to be discriminated, classifying them into three Background and aims.– It has been widely studied that changes in
subgroups. BS prevalence decreased and vulnerability factors were sleep and circadian rhythm might be early predictors of severe
attenuated when students had a higher frequency of participation mental illness. Although only a modest group of patients will
in BG. develop a severe mental illness, simple and cost-effective interven-
Conclusions.– The prevalence of two-dimensional BS was high with tions might be useful to reduce the risk of psychopathology. Here
factors associated with the educational process. Participation in BG we present and discuss a case in which it seems to be clear that
was associated with a reduction in BS prevalence. changes in circadian rhythm is a prodrome of psychotic symptoms
Disclosure of interest.– The authors have not supplied a conflict of and in which a psychoeducational intervention was beneficial in a
interest statement. patient with bipolar disorder (BD).
Methods.– Relevant clinical information was collected from the
patient’s interview and clinical process. In addition, a review of the
E-PP0863
literature was performed by searching the Pubmed database.
Internet use and perception as Results.– Forty-six-year-old man with no relevant personal back-
indicators for psychopathological ground until the age of 20, when he was hospitalized and diagnosed
symptoms in youth and adults: with Type I BD. Since then, during his outpatient community
comparisons of anxiety, interpersonal follow-up, usually after he changed his sleep habits for a few days,
he presented with psychotic symptoms, even with full medica-
sensitivity and aggression tion compliance. With a series of psychoeducational interventions
E. Rasskazova1* , G. Soldatova2
1 focused on circadian rhythms and sleep habits, it has been possible
Moscow State University, Clinical Psychology, Moscow, Russia; 2
to manage and reduce the frequency of these episodes in outpatient
Moscow State University, Personality Psychology, Moscow, Russia
* Corresponding author. settings.
Conclusions.– The existence of a sleep disturbance prior to a diag-
Background and aims.– Changing the context of personal social- nosis of a severe mental illness raises the opportunity to prevent or
ization, Internet use could also affect risk for psychopathological slow the progression of the disorder. The focus of psychoeducation
symptoms that is important in diagnostic especially in youth. on sleep and circadian rhythm patterns may be a cost-effective way
The aim was to reveal the role of Internet use, perception and Inter- of intervention.
net addiction in psychopathological symptoms in two generations: Disclosure of interest.– The authors have not supplied a conflict of
youth comparing to adults. interest statement.
Methods.– 736 youth (18–30 years) and 1105 adults (30–65 years)
from 8 Federal regions in Russia appraised perceived danger
E-PP0865
including macro-social (e.g., “in my city”, Cronbach’s ␣ = .86-.87),
micro-social (e.g., “at home”, Cronbach’s ␣ = .61-.64) and the Inter- The role of sleep in individuals at-risk
net, filled Anxiety and Interpersonal Sensitivity scales from SCL-90R for psychosis
(Derogatis, 1994), Aggression Questionnaire (Buss, Perry, 1992), H. Simião1* , L. Arruda Linhares2
Internet Addiction Scale (Mak et al., 2014). 1 Centro Hospitalar de Lisboa Ocidental, Psychiatry, Lisbon, Portugal;
Results.– After controlling for other perceived danger, perceived 2 Centro Hospitalar Lisboa Norte, Department of Psychiatry, Lisbon,
danger in the Internet predicted anxiety in youth (␤ = .08, R2 = .6%, Portugal
p < .05). Internet addiction improved prediction for R2 = 5.3% * Corresponding author.
(␤ = .23, p < .01) but didn’t eliminate the effect of perceived dan-
ger. In adults user activity but not perceived danger in the Internet Background and aims.– Sleep disturbances increase the risk for psy-
predicted anxiety (␤ = .08, R2 = .6%, p < .05) and this effect disap- chotic experiences. In bipolar disorder and schizophrenia, circadian
peared after adding Internet addiction (␤ = .32, R2 = 10.2%, p < .01). rhythm disruption has been described as hallmark for both disor-
Both hostility and anger were negatively related to perceived dan- ders, with a prevalence for the latter reported to be as high as 80%.
ger in the Internet (␤=-.09, R2 = .5-.7%, p < .05) and positively to The aim of this review is to clarify the directionality between sleep
Internet addiction (␤ = .27-.47, R2 = 6.3–14.8%, p < .01). Interper- disruption and psychosis in individuals at-risk.
sonal sensitivity, physical aggression in both groups depended on Methods.– We performed a systematic review of the literature of
macro-social danger and Internet addiction only. the last 5 years by searching the Pubmed database the keywords
Conclusions.– Although severe Internet misuse is obviously related “psychosis” or “psychotic”, “risk” and “sleep”.
to wide range of psychopathology, normative perception of danger Results.– Variations of circadian cycle over 5 days of monitoring
in the Internet could affect specific anxiety in youth but suppress predicted more severe psychotic symptoms (in certain specific
anger and hostility in youth and adults. Study is supported by the domains) and more psychosocial dysfunction. On the other hand,
Russian Science Foundation, project 18-18-00365. the subjective perception of sleep quality seems to be a protec-
Disclosure of interest.– The authors have not supplied a conflict of tive effect for psychotic phenomena, even when sleep duration is
interest statement. less than 7.5 hours. Young individuals at high risk for psychosis are
more susceptible to sleep changes and are associated with worse Results.– At admission, the score was CGI-S = 6 (severely ill). She
outcomes. was brought to the hospital after police found her wandering in
Conclusions.– There is evidence that sleep deprivation or poor qual- the streets. At hospital admission, this patient presented with con-
ity of sleep can increase the severity of psychotic experiences. In fusion, agitation, violence, assault of staff, and visual hallucinations.
patients at risk for psychosis, sleep disorders are predictive of a The urine was negative for recreational drugs. After inspection
greater severity of psychotic symptoms. Sleep patterns should be of clinical notes, the working diagnosis was PGAW. The team
assessed and treated when disturbed in psychotic patients and started a short course of Diazepam 5 mg four times daily to con-
patients at risk. trol her behaviour and reduce Pregabalin withdrawal. Presenting
Disclosure of interest.– The authors have not supplied a conflict of symptoms of PGAW were: lethargy, confusion, low mood, anxiety,
interest statement. and agitation [http://www.treatment4addiction.com/drugs/lyrica/
]. At day 2, she had CGI-S = 4 (moderately ill) and CGI-I = 3 (mini-
mally improved) she started to develop symptoms of withdrawal
E-PP0866 including sweating, tachycardia, carving for Pregabalin, depression,
Problematic gaming and social media insomnia and anxiety, nausea, and diarrhoea. At day-3, she was
use: assessment and statistical much improved. She had CGI = 1 (very much improved) and CGI-
S = 2 (subtle pathology). After 17 days, she was discharged from
predictors
hospital asymptomatic.
O. Király* , Z. Demetrovics
Conclusions.– Healthcare professionals should consider the risk of
ELTE Eötvös Loránd University, Institute of Psychology, Budapest,
Pregabalin addiction and withdrawal in all patients who are on this
Hungary
* Corresponding author. medication or who request strong tablets for anxiety symptoms.
Background and aims.– The incredible advancement and high acces- interest statement.
sibility of the internet brought along both positive and negative
changes in our lives. One of the most crucial questions – receiv-
ing continuously increasing research interest – is how online video E-PP0868
gaming and social media use effects the development of children Modern features of adaptation
and adolescents and the lives and mental health of young adults. disorders in people with computer
Besides the evident positive consequences of these applications addiction
(e.g., means to relax, improving a large variety of skills, increas- I. Leshchyna* , H. Kozhyna, M. Markova, Y. Starodubtseva, V.
ing social relatedness), possible negative consequences, including Koshchii
the problematic or addictive use, have emerged as well. Kharkiv National Medical University, Psychiatry, Narcology and
Methods.– The presentation gives an overview of the recent Medical Psychology, Kharkiv, Ukraine
advancements in the assessment of problematic use (i.e., screen- * Corresponding author.
ing and diagnosis), an important topic within this research field.
Furthermore, it also reviews some of the statistical predictors of Background and aims.– Particular concern in society is addic-
these problem behaviors. tive behavior in young people. Purpose: comprehensive study of
Results.– Gender appears to be crucial both in the use of social media clinical-psychopathological and pathopsychological peculiarities
and video games, the former being used more among girls, while of adaptation disorders in people with computer addiction.
the latter among boys. While time spent using these applications Methods.– A complex examination of 147 patients with adaptive
appears not to be a good predictor of problematic use if assessed disorders was conducted (F43.21, F43.22). The main group included
alone, psychiatric symptoms (e.g., depressive symptoms, anxiety), 85 patients with signs of computer addictionin accordance with the
low self-esteem, the use of certain emotion regulation strategies, results of AUDIT-like tests (Linskyi I.V., 2009), the control group: 62
and escapism as a motivation (i.e., using these applications to avoid patients with no signs of addictive behavior.
real life problems) appear to be better indicators. Results.– The structure of computer addiction in the examined peo-
Conclusions.– The problematic use of certain internet-related activ- ple of the main group was the following: obsessive surfing -46.2%
ities is a relatively new concern; however, one that certainly needs patients; 22.3% -computer games; 6.4% -virtual dating; 13.7% -
our attention. passion for online gambling; 1.4% -cybersex. In the clinical image
Disclosure of interest.– The authors have not supplied a conflict of of adaptation disorders there was decreased mood (73.4% main
interest statement. and 74.1% control group); mood swings, propensity to short-term
disruptive reactions (52.1% and 39.6%, respectively); the feeling of
anxiety (69.7% main and 52.1% control group); confusion (55.4% and
E-PP0867 54.2% respectively); asthenic symptom complex (84.5% and 82.3%
Pregabalin addiction and withdrawal respectively). The examined patients are characterized by the clin-
in primary and secondary care ical manifestations of anxiety and depression on the scale of HADS
C. Lazzari* , A. Nusair -72.1% main and 65.4% control group; severe depressive (48.1%
Fieldhead Hospital, Southwest Yorkshire NHS Trust, Psychiatric and 41.1%) and anxious (54.2% and 43.2% respectively) episodes
Intensive Care Unit, Wakefield, United Kingdom on the HDRS scale; high levels of situational (43.5% and 39.7%) and
* Corresponding author. personal (53.1% and 49.8%, respectively) anxiety.
Conclusions.– The obtained data of clinical and psychopathological
Background and aims.– Pregabalin is the primary medication used manifestations and psychopathological features of adaptation dis-
for anxiety. However, there is an increase in Pregabalin abuse for orders in people with computer addiction should be the basis for
recreational use out of doctors prescribing. Aim of the current the development of a comprehensive program of therapy and reha-
study is to describe a case of Pregabalin Addiction and Withdrawal bilitation of patients with disorders of adaptation and computer
(PGAW). addiction.
Methods.– The Clinical Global Impression (CGI) [Busner & Targum, Disclosure of interest.– The authors have not supplied a conflict of
2007] scale described the clinical presentation with the two sub- interest statement.
scales CGI-S = Severity, and CGI-I = Improvement. The case refers to
a 50-year old woman with a long history of Pregabalin abuse.
E-PP0869 Results.–
Outcome effectiveness of brief alcohol 61 percent of patients had opioids prescribed for pain. Average
interventions on drinking behaviours daily dose: 275’66 MME.
60 percept presented criteria according to DSM-V to OUD. Average
of male inpatients in a general daily dose: 350’34 MME.
hospital in Singapore Dose interval: 8.000- 8,3 MME.
Z.W. Lew* , C.S. Lim, Y.C. Ng, P.W.L. Teo, L.H. Peh 64’70 percent of the cases agreed to perform a rotation with
Changi General Hospital, Department of Psychological Medicine, buprenorphine. The average dose of buprenorphine correspond-
Singapore, Singapore ing to the doses of opioids taken before rotation was 7.76 mg. The
average dose of buprenorphine after rotation was 5.71.
Conclusions.– More than a half of patients with CNCP and psychiatric
pathology are treated with opioids and more than a half of this
Introduction.– Many patients admitted into general hospitals
group will end up showing OUD. The difference between the doses
present with alcohol behaviours and problems. This can present as
of buprenorphine estimated before the rotation and the real ones
opportunities for intervention due to accessibility and time (Saitz,
after the process, supposes that, with the rotation, we can achieve
Palfai, Cheng, Horton, Freedner, Dukes, Kraemer, Roberts, Guerriero
a total decrease on average of daily dose 150 MME, without having
& Samet, 2007), and evidence suggests that alcohol brief interven-
increased the level of basal pain.
tions (ABI) delivered in this setting can be effective (e.g., review by
McQueen, Howe, Allan, Mains & Hardy, 2011). Currently, no study
interest statement.
has investigated this in Singapore.
Objective.– This study investigated the effectiveness of ABIs for
patients admitted to a Singapore general hospital on drinking E-PP0871
behaviours and perceived sense of well-being.
Methods.– 68 non-psychiatric inpatients received ABI by the hos-
Metabolic therapy in complex
pital’s addiction counsellors during admission and were followed treatment of depressive disorders in
up at 12 months via telephone. Measures included the Alcohol patients with alcoholism
Use Disorders Identification Test (AUDIT) as a measure of alcohol Y. Lyan* , Z. Ashurov
consumption behaviours, the number of standard drinks (SD) per Tashkent Medical Academy, Psychiatry and Narcology, Tashkent,
drinking occasion, and the Personal Wellbeing Index (PWI) as a Uzbekistan
measure of perceived wellbeing.
Results.– AUDIT scores and SD per drinking occasion were signifi-
cantly lower at follow-up (M = 1.34, SD = 1.75; M = 1.71, SD = 1.76) Background and aims.– Alcoholism remains as a major issue in psy-
than at hospitalization (M = 3.47, SD = 4.85; M = 3.45, SD = 2.50; chiatry, as well as depressive disorders in patients with alcoholism.
p < .01). PWI scores were higher at 12 months (M = 7.96, SD = 1.21) The aim of the study was a research of the influence of the metabolic
than at baseline (M = 7.68, SD = 1.14; p < .01). therapy on depressive disorders in patients with alcoholism.
Conclusions.– Results suggest that ABI in a Singapore general hospi- Methods.– 60 patients with alcoholism with depressive disorders
tal can be beneficial in reducing patients’ drinking behaviours and in postabstinent period were studied. In order to identify depres-
improving perceived wellbeing. sion and vegetative disorders Hamilton Depression Rating Scale
Disclosure of interest.– The authors have not supplied a conflict of and Wayne questionnaire were applied.
interest statement. All patients were divided by random selection into 2 groups of 30
people - antidepressants and cognitive behavioral therapy (CBT)
were applied in the control group and antidepressants, CBT and
E-PP0870 metabolic therapy (Inosine, Nicotinamide, and Succinic acid) were
applied in the main group (figure 1)
Dose of morphine and buprenorfine in
chronic non oncologic pain
T. López-Arteaga1* , P. Padilla-Romero2 , J.M. Gallego-Bellido3 , C.
Romero-Martín4
1 Psychiatrist, Department of Psychiatry- Hospital Ntra. Sra. del
Prado, Talavera de la Reina TO- C.P. 45600, Spain; 2 Hospital Ntra.

Sra. del Prado, Psychatry, Talavera de la Reina, Spain; 3 Addictive
Behaviour Unit. Hospital Ntra. Sra del Prado, Psychiatry, Talavera de
la Reina, Spain; 4 Hospital Ntra. Sra. del Prado, Hospital Pharmacy,
Talavera de la Reina, Spain

• Introduction.– Chronic non cancer pain (CNCP) affects a third of
Europeans. Although opioids are not indicated as the first line of
treatment, it is common to observe population with these drugs.
• Objetives.– Determine the percentage of opioid analgesic users
prescribed for Pain Unit (PU) patients who are assessed by psy-
chiatry in a year and see the percentage of opioids use disorder
(OUD) in this sample. Determine the average doses of opioids Figure 1. Results: depression and vegetative disorders Hamilton
used before and after rotation with buprenorphine in morphine Depression Rating Scale and Wayne questionnaire.
miligrams equivalents (MME).
Methods.– Results.– In the course of the therapy a rapid reduction of patholog-
• Prospective descriptive study. Sample: 187 patients evaluated by ical symptoms was noted in the main group, patients subjectively
the department of psychiatry in the year 2017 derived from (PU) felt good either mentally and physically. The improvement of the
for psychopathological assessment. patients in the main group was mainly associated with a decrease
or reduction of headache, sleep disorder and fatigue.
Conclusions.– It can be assumed that depressive disorders in postab- Cannabis use is a widely common habit in interns and residents,
stinent period in patients with alcohol dependence occur largely nevertheless there is little research on the subject. The aim of this
due to vegetative disorders which are a direct result of a toxic effect study was to evaluate the consumption of cannabis among this pop-
of ethanol on the central nervous system. Therefore the reduction ulation of medical interns and residents to identify the misuse and
of vegetative disorders, along with the improvement of coronary to act for a better prevention and educational strategies.
and cerebral blood flow, activation of metabolic processes in the Methods.– 77 participants were included in this study and
central nervous system and improvement of cognitive functions responded to an anonymous auto questionnaire on line. It collected
is an optimal treatment strategy, as well as a psychotherapy and demographic, socio-economic data and data on cannabis use. The
psychopharmacotherapy. Thus, metabolic therapy for depression risk of problematic use was assessed by the CAST (Cannabis Abuse
in patients with alcoholism seems justified. Screening Test) questionnaire in its French version.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Our sample contained 77 participants, 78.9% were females
interest statement. and 21.1% were males. The mean age was 27 years old. 60.8% were
residents and 39.2% interns. 46.7% of the participants were unsat-
isfied with their work. Cannabis consumption was seen in 19% of
E-PP0872 the participants, 13.2% of them were with a problem use (CAST> = 2)
Smartphone addiction, anxiety and and the circumstances of this use were multiple. In 78.9% of cases, it
depression among tunisian university was associated with festivity,10.5% with performance anxiety,5.3%
with a stressing life event and 5.3% as an addiction. The rhythm
students
of consumption was daily in 5.9% of cases, Regular in 11.8% and
M. Daoued1 , M. Maalej2* , M. Yosra3 , S. Omri1 , M. Ben Jemaa3 , M.
occasional in 82.4%.
Ben Yahya4 , S. Yaïch3 , L. Zouari1 , M. Maalej1 , J. Dammak3 , N.
Conclusions.– The use of cannabis by medical senior students is
Charfi1 , J. Jedidi3 , J. Ben Thabet1
1 Hedi Chaker University Hospital Faculty of Medicine Of Sfax, a phenomenon that should be highlighted due to its prevalence
and potential impact but we need to identify what is beneath the
Psychiatry “C”, Sfax, Tunisia; 2 Psychiatry “C” Department, CHU Hédi
iceberg: the psychological distress.
Chaker Sfax, Psychiatry “C” Department, Sfax, Tunisia; 3 Hedi Chaker
University Hospital Faculty of Medicine Of Sfax, Preventive Medicine,
interest statement.
Sfax, Tunisia; 4 University of Sfax, Higher Institute of Nursing
Sciences, Sfax, Tunisia
E-PP0874
Background and aims.– University students use their smartphones The association of oxytocin gene
very often and for different purposes. They are exposed to smart- polymorphism with psychological
phone addiction, which is a growing phenomenon, as well as to distress and suicidal ideations in
anxiety and depression.
alcohol-dependent patients
Our objective was to assess smartphone addiction, anxiety and
A. Mach1* , A. Klimkiewicz1 , S. Fudalej1 , A. Jakubczyk1 , A.
depression levels among Tunisian university students.
Wnorowska1 , M. Kopera1 , K.J. Brower2 , M. Wojnar1,2
Methods.– We carried out a cross sectional study among 756 1 Medical University of Warsaw, Department of Psychiatry, Warsaw,
students of faculties in Sfax (Tunisia), during the academic
Poland; 2 University of Michigan, Department of Psychiatry, Ann
year 2017/2018. Each participant filled in a questionnaire which
Arbor, USA
included, among others, the Smartphone Addiction Scale- short * Corresponding author.
version (SAS-SV) and Hospital Anxiety and Depression Scale (HAD).
Results.– Among our participants, 28.7% were men and 71.3% were Background and aims.–
women. Three hundred and eighty-seven (51.2%) students had Introduction.– Oxytocin (OXT) was shown to have anxiolytic and
an addiction to Smartphones. The average score of addiction to antidepressant properties. Genetic variation in oxytocinergic sig-
Smartphones was 34.2. About one fourth of the students in our sam- naling may play an important role in modulation of psychological
ple were smokers (24,4%), one-sixth were alcohol drinkers (16%), distress, which may influence development and course of alcohol
one-half were depressed (55%), and two-third were anxious (63%). dependence (AD) and may affect severity of suicidal ideations (SI).
Women had an addiction to the Smartphone less than men (50.8% However, to date relationships between OXT genotype, psycholog-
vs 52.1%, p = 0,002). The smartphone addiction group also showed ical distress and suicidal ideations have not been investigated in AD
an increased risk of depression (p < 0.001) and anxiety (p < 0.001). sample.
Conclusions.– University students in Tunisia are at risk of addiction Objectives.– The aim of this study was to analyze relationships
to smartphones. Such a phenomenon requires specific manage- between OXT gene polymorphisms and psychological distress as
ment as it negatively affects many areas of their lives: sleep, levels well as severity of SI in AD patients.
of energy, eating habits, weight, exercise, and academic perfor- Methods.– The study included 288 adults diagnosed with a DSM-
mance. IV alcohol dependence. The Global Severity Index (gsi) was used
Disclosure of interest.– The authors have not supplied a conflict of to assess the level of psychological distress, and the Beck Scale for
interest statement. Suicidal Ideation - to measure the severity of SI. Also, Substance
Abuse Outcomes Module and Fagerstrom Test for Nicotine Depen-
dence were utilized. Single nucleotide polymorphisms: rs4813625,
E-PP0873
rs877172, rs3761248 and rs2740210 in OXT gene were analyzed.
Cannabis use among medical interns Results.– The statistical analysis, including the Bonferroni correc-
and residents: an observational study tion, showed a significant association between the GT genotype
R. Maamouri1* , N. Bram2 , R. Maalej1 , I. Ben Romdhane2 , W. rs2740210 polymorphism of OXT gene with symptoms of psycho-
Homri2 , R. Labbane2 logical distress (higher gsi) in specific subgroups, i.e. the association
1 Medical School of Tunis, Psychiatry, Tunis, Tunisia; 2 Hospital Razi,
appeared only in patients with alcohol problems in the fam-
Psychiatry ‘C’ Department, Mannouba, Tunisia ily p = 0.0029; post-treatment relapse p = 0.0098 in 1-year period;
history of regular smoking p = 0.0093). This genotype was also asso-
Background and aims.– Psychoactive substance use among medi- ciated with the higher severity of SI in patients with relapse after
cal students is a serious current health problem in our country. treatment (p = 0.0048).
Conclusions.– Genetic variation in oxytocin gene may influence was 16.7%, 33.3% and 33.3% respectively in pharmacotherapy group
psychological distress and severity of SI in special groups of AD and 45.5%, 54.5% and 54.5% in combined therapy group (p < 0.05).
patients. Conclusions.– Combined therapy was found to be significantly more
Disclosure of interest.– The authors have not supplied a conflict of effective than pharmacotherapy alone in both smoker as well as
interest statement. smokeless tobacco user group.
interest statement.
E-PP0875
The attachment style in
cyberaddictions E-PP0877
F. Medini1* ,
L. Menif Medini2 , W.Melki2 ADH4 gene polymorphisms in patients
1 Razi Hospital, Razi Hospital, Mannouba, Tunisia; 2 Hospital Razi, with alcohol dependence –
Psychiatry, Mannouba, Tunisia associations with lesch’s typology and
the family history of alcoholism
Background and aims.– Our work aims at a better understanding of A. Michalczyk* , I. Małecka, J. Samochowiec
the link between attachment and pathological Internet use. Pomeranian Medical University in Szczecin, Department of
Methods.– All the participants completed two self-report question- Psychiatry, Szczecin, Poland
naires: Relationship Scale Questionnaire (RSQ), Internet Addiction
Test (IAT). The self-administered questionnaires have been put
Background and aims.– Genetic factors play an important role in
online. The link to the form was distributed by email and social
susceptibility to addiction. Previous studies showed, that poly-
networks.
morphisms in ADH4 gene are associated with the risk of alcohol
Results.– Participants: all-comers adults (n = 63) aged 18 to 61 .63%
dependence, but little is known about its associations with partic-
women.
ular disease phenotypes. The aim of the study was to investigate the
In our work we find that problematic Internet use is linked to
associations between polymorphisms in ADH4 gene and the type
attachment insecurity. People with a score preoccupied attachment
of alcoholism according to Lesch’s typology, and the family history
and fearful prove and more to others on the Internet than they do
of alcoholism.
face-to-face there was a statistically significant relationship p = 0,05
Methods.– DNA samples were obtained from venous blood of 160
between the score in Internet Addiction Test (IAT) and the detache
male patients with alcohol dependence and 97 healthy controls
style in Relationship Scale Questionnaire (RSQ);
matched by age and sex, all of Polish descent. The patients group
Conclusions.– The attachment concern is a factor related to the
was divided into subgroups according to the Lesch’s typology and
problematic use of the Internet. A supported taking account of
the family history of alcoholism. In all samples polymorphisms
the motivations for the attachment could reduce the use of virtual
rs1042364 and rs1800759 in ADH4 gene were determined using
world.
the real-time PCR technique. Results were analyzed using the chi-
square tests in SPSS version 21.
interest statement.
Results.– In patients with Lesch’s type III of alcoholism, genotype AG
in rs1042364 was significantly more frequent than in control group
(p = 0.003). In patients with other types of alcoholism, there were
E-PP0876
no significant differences compared to control group. Genotype AG
Efficacy of pharmacotherapy versus in rs1042364 was also significantly more frequent in patients with
combined therapy in tobacco Lesch’s type III, compared to other types of alcoholism (p = 0,032).
cessation: a prospective comparative There were no significant differences in genotypes frequencies
study between patients with and without family history of alcoholism.
A. Mehdi Conclusions.– Results suggests that polymorphism in rs1042364
Career Institute of Medical Sciences, Psychiatry, Lucknow, India may be associated with type III of alcoholism according to Lesch’s
Background and aims.– In view of skyrocketing number of cases typology. Further studies are necessary to confirm this relationship.
leading to increased prevalence of tobacco use, especially in devel- Disclosure of interest.– The authors have not supplied a conflict of
oping countries the interventions for smoking cessation have interest statement.
become an urgent need. The aim of the present study is, to know
the effect of pharmacotherapy alone and pharmacotherapy with
E-PP0878
psychotherapy on tobacco cessation.
Methods.– It is a prospective cohort study conducted in 75 subjects The role of personality traits and
(Pharmacotherapy alone group, n = 38; pharmacotherapy with psy- emotional intelligence in internet
chotherapy group n = 37). Subjects were randomly allocated into addiction of university students
two groups. Medication was given to all the subjects with bupro- G.A. Nikpour1* , A.R. Homayouni2 , S.J. Mosavi Amiri3
pion (300 mg) based on the severity of tobacco addiction while 1 Department of Psychology, Allameh Tabatabaii University, Tehran,
psychotherapies were individually tailored and delivered only in Iran, Iran; 2 Department of Psychology, Bandargaz Branch, Islamic
one group. Azad University, Bandargaz, Iran, i, i, Iran; 3 Dept. of Addiction
Results.– Tobacco abstinence rates in both the groups differ Treatment, Medical Clinic of Dr. Mosavi, Babol, Iran, l, l, Iran
markedly. Overall, 22.7% (n = 17) of the subjects were smoker while * Corresponding author.
majority of them belonged to smokeless group (77.3%, n = 58). The
overall rates of continuous abstinence at 6, 8 and 12 weeks were Background and aims.– The aim of this research was investigation
26.3%, 28.9% and 28.9% respectively in pharmacotherapy group, the role of personality traits and emotional intelligence in to inter-
while in other group it was 47.3, 54.1, and 54.1 respectively. In net addiction.
Smokeless group it was 28.1% at week 6, 8 and 12 in pharma- Methods.– 95 university students were selected and Mc Care
cotherapy group and 50%, 53.8% and 53.8% respectively in combined & Costa’s NEO PI-R Inventory, Shutte’s Self-report Emotional
therapy group while in smokers abstinence rate at 6, 8 and 12 weeks Intelligence Test and Addiction to Internet Questionnaire were
administered on them. The data were analyzed with Spearman E-PP0880

correlation coefficient formula. Hospital emergencies among
Results.– Findings showed that there is negative and significant cor-
underage consumers of psychoactive
relation between components of emotional intelligence (Appraisal
of emotion, regulation of emotion and utilization of emotion) with
substances
addiction to internet. Also, findings showed that there is negative P. Padilla Romero1* , C. Romeromartin2 , T. López-Arteaga1 , M.T.
and significant correlation between personality trait of Neuroticism Perez Castellano1
1 Hospital Nuestra Señora del Prado, Psychiatry, Talavera de la Reina,
with utilization of emotion, and positive and significant correla-
tion between personality traits of Extroversion, Openness to new Spain; 2 Hospital Nuestra Señora del Prado, Hospital pharmacy,
experience, and Conscientiousness with components of emotional Talavera de la Reina, Spain
intelligence.
Conclusions.– Based on results, it is concluded that personality traits Background and aims.–
and emotional intelligence can predict the internet addiction. Introduction.– Nowadays, illicit drug abuse is increasing among
Disclosure of interest.– The authors have not supplied a conflict of underage patients. This composes a risk factor to the development
interest statement. of psychiatric disorders.
Objectives.– Assess which are the most consumed drugs by under-
age people. Evaluate which type of medical-psychiatric disorders
E-PP0879
susceptible to hospital emergencies originates from these drugs
Benzodiazepine use in a methadone consumption.
maintenance programme: Methods.– Restropective case-series descriptive study. Clinical data
consumption characteristics and were collected from underage patients who went to emergency
clinical outcomes services for drug abuse during one year in 2017.
C. Oliveira1* , R. Filipe2 , M. Maia3 , M. Carvalho3 , G. Leme3 , L. Results.– A total 110 patients were evaluated (59% male). The
Sampaio4 , J. Meira4 , L. Teixeira4 , J. Rodrigues4 , C. Machado3 , C. median age was 16 years old (17–14). The consumed drugs were:
Fiuza3 , I. Nunes4 , J. Tavares5 cannabis (59.09%; n = 65), alcohol (36.36%; n = 40) and cocaine
1 Hospital Prof. Dr. Fernando Fonseca, Psychiatry, Lisboa, Portugal; 2 (4.54%; n = 5). The associated diagnosis to clinical history documen-
Community Health Center of Western Lisbon and Oeiras, Public tation was (from higher to lower fequency): alcohol intoxication,
Health, Oeiras, Portugal; 3 Drug Addiction Treatment Unit, behavioral disorders, Anxiety Attacks, autolytic gesture and Psy-
Psychology, Agualva-Cacém, Portugal; 4 Drug Addiction Treatment chotic attack.
Unit, Methadone Division, Agualva-Cacém, Portugal; 5 Drug Conclusions.– Most underage people who go to emergency services
Addiction Treatment Unit, Psychiatry, Agualva-Cacém, Portugal for drug abuse are male. The most consumed drug is cannabis, fol-
* Corresponding author. lowed by alcohol, and then by cocaine. No emergency episodes for
opiates consumption were found.
Background and aims.– Portugal has one of the highest rates of Alcohol intoxication is found among most frequent diagnoses. This
benzodiazepine’s (BZD) consumption in Europe. In the substitu- fact indicates that alcohol consupmtion by young people is getting
tion programs with opioid agonists, it is found that BZD users have started at younger ages. It is worth mentioning the fact that all
poor adherence and response to substitution treatment, leading to diagnosed cases of Psychotic attack had clinical history of cannabis
a worse psychosocial and rehabilitative prognosis. consumption.
This study aims to determine the prevalence and patterning of BZD This study shows the necessity to promote prevention means to
consumption. reduce drug abuse in vulnerable groups, such as underage people.
Methods.– We conducted a cross-sectional involving 171 patients Disclosure of interest.– The authors have not supplied a conflict of
treated in the public methadone maintenance programme of interest statement.
Agualva-Cacém Drug Addiction Unit. A descriptive analysis was
made to determine the prevalence and patterning of BZD consump-
tion and bivariate analysis was performed between the BZD users E-PP0881
and non-users, adopting a level of significance of 0.05. Alexithymia and buprenorphine
Results.– The prevalence of BZD consumption was 25.4%. The major- addiction
ity of BZD users were male (90%), with a median age of 46.8 years, F. Ghali1 , O. Meziou1 , L. Sahli2* , G. Jmii1 , M. Zghal1 , H. Zalila1
were not married (64.2%), had nine years of education (69.9%), had 1 Razi Hospital, Psychiatry Department, Tunis, Tunisia; 2 Monji Slim
legal problems (66.7%) and consumed BZD more than 3 times/week Hospital, Child Psychiatry Department, Tunis, Tunisia
(83.1%). Comparing with the non-users, BZD users required higher * Corresponding author.
daily doses of methadone (79.7 mg vs. 63.3 mg, p = 0.041), had a
higher prevalence of Hepatitis C (70% vs 46.2%, p = 0.001), a higher Background and aims.– It’s currently admitted that vulnerability to
consumption of cannabinoids (41.7% vs 27.8%, p = 0.046) and had a substance use disorders results from the interaction of several fac-
higher use of BZD in the past (90% vs 64.8%, p < 0.001). tors related to the product, the environment or to the individual.
Conclusions.– Our results suggest that besides benzodiazepine Our aim was to study the alexithymia as a personality dimension
®
prevalence intake was lower than other studies, the chronicity of among subjects addicted to buprenorphine (Subutex ) compared
this consumption is very high and have a health negative impact. to controls.
In this sense, the evaluation of BZD consumption should be always Methods.– We conducted a cross sectional comparative study
®
be addressed seriously in methadone programmes. including 50 patients with addiction to buprenorphine (Subutex )
Disclosure of interest.– The authors have not supplied a conflict of and 50 witnesses. We collected sociodemographic informations,
interest statement. history and addictive course using a data record. We estimated
alexithymia with the Toronto Alexithymia Scale (TAS-20).
Results.– Mean score of alexithymia on TAS-20 with users of
®
buprenorphine (Subutex ) was significantly higher than among
the control population: 63,42 versus 53,54 (p < 0,001). Alexithymia
was strongly associated with buprenorphine addiction (54% versus
24% p = 0,002). The unemployment, the family judicial history, the
personal psychiatric history, the poly drug use and the high level E-PP0883
of seeking sensation were identified as risk factors of addiction to Sterile inflammation of brain as a
®
buprenorphine (Subutex ). culprit in mental disorders
Conclusions.– The good knowledge of buprenorphine addiction’s J. Kucharska-Mazur1* , M.Z. Ratajczak2,3 , B. Dołegowska
˛ 4 , M.
risk factors is absolutely crucial. It allows prevention initiatives Jabłoński1 , A. Reginia1 , J. Samochowiec1
targeted for these contexts of vulnerability, thanks to the imple- 1 Pomeranian Medical University, Dept. of Psychiatry, Szczecin,
mentation of an adapted and early psychosocial support. Poland; 2 University of Louisville, Stem Cell Biology Program at the
Disclosure of interest.– The authors have not supplied a conflict of James Graham Brown Cancer Center, Louisville, USA; 3 Medical
interest statement. University of Warsaw, Center for Preclinical Research and
Technology, Warsaw, Poland; 4 Pomeranian Medical University,
Dept. of Laboratory Medicine, Szczecin, Poland
E-Poster Presentation: Psychoneuroimmunology /
Others - Part II Background and aims.–
Introduction.– Research conducted thus far by our team related to
circulating in peripheral blood stem cells and increase in inflam-
E-PP0882 matory markers supports a concept that inflammation of the brain
The impact of war trauma and plays a role in etiopathogenesis of psychiatric disorders.
Objectives.– The goal of our research was to shed more light
post-displacement stressors on
how cytokines and chemokines, in the peripheral blood, influence
depression, energy and inflammatory processes in the brain.
anti-inflammatory interleukin Methods.– We evaluated in peripheral blood i) a number of circu-
B. Arnetz1* , S.A. Keaton2 , J. Arnetz1 , H. Jamil1 , S. Krzyzanowski3 , L. lating various types of stem cells, ii) components of complement
Brundin4 , P. Stemmer5 , J.B. Yamin6 cascade activation, iii) level of sphingosine-1-phosphate, as well as
1 College of Human Medicine, Michigan State University, Family
stromal cell-derived factor-1 (SDF-1) - in patients suffering from
Medicine, Grand Rapids, Michigan, USA; 2 Van Andel Institute, a first psychotic episode, anxiety attacks and in bipolar affective
Degenerative Neuroscience, Michigan State University, Physiology, disorder.
Grand Rapids, USA; 3 Van Andel Institute, Degenerative Neuroscience, Results.– We noticed in peripheral blood of studied patients an
Physiology, Grand Rapids, USA; 4 Van Andel Institute, increase in number of circulating stem cells, activation of comple-
Neurodegenerative Neuroscience, Grand Rapids, USA; 5 Wayne State ment cascade and increase in level of sphingosine-1 phosphate.
University, Institute for Environmental Health Sciences, Detroit, Based on this a hypothesis has been formulated that prolonged
Michigan, USA; 6 Wayne State University, Psychology, Detroit, activation of complement cascade in mannan binding lectin
Michigan, USA pathway-dependent manner, may activate an inflammation pro-
cess in the brain. This process however can be ameliorated by
anti-inflammatory effects of heme oxygenase-1.
Background and aims.– Persons exposed to war commonly suffer
Conclusions.– Sterile inflammation of the brain can trigger onset of
from symptoms that do not meet the criteria for post-traumatic
mental disorders.
stress disorder. Fatigue and lack of energy are common symptoms.
The aims of the project were to: 1.validate user-friendly instru-
interest statement.
ments to assess energy and fatigue as they relate to exposure to
trauma and PTSD, and 2. to determine the relationship between
these and pro- and anti-inflammatory interleukins. E-PP0884
Methods.– A total of 60 newly arrived refugee men and women
from Syria and Iraq were recruited within a month after arriving
Features of functioning of cytokine
in the United States. The participants responded to a structured system of schizophrenic patients
survey in Arab covering socioeconomics, resilience factors, and under long-term therapy with
trauma exposures. In addition, participants were assessed for anx- risperidone
iety, depression and PTSD, using PLC-C. Participants used Visual O. Lobacheva1* , V. Nikitina1 , E. Kornetova2 , Y. Maltseva2
analogue scales (VAS) to rate their: stress, quality of sleep, ability 1 Mental Health Research Institute- Tomsk National Research
to concentrate, fatigue, and energy. Blood was sampled for deter- Medical Center of Russian Academy of Sciences, Department of
mination of interleukin 6, TNF-␣, and interleukin 10. The study was Clinical Psychoneuroimmunology and Neurobiology, Tomsk, Russia; 2
approved by the Wayne State University IRB. Mental Health Research Institute- Tomsk National Research Medical
Results.– Higher trauma scores correlated with PTSD scores (r = 0.48, Center of Russian Academy of Sciences, Department of Endogenous
p < 0.01). Disorders, Tomsk, Russia
PTSD scores correlated inversely with self-rate energy (r = -.27, * Corresponding author.
p < 0.05) and ability to concentrate (-0.30, < 0.05), but directly with
stress ratings (0.33, p < 0.01). Background and aims.– Immune dysfunctions, alteration of cytokine
Interleukin 10 correlated directly with energy (r = 0.38, p < 0.05), profile lead to impairment of neuroimmune interaction and can
but inversely to the ratio TNF-␣/Interleukin 10 (−0.37, < 0.05). be a risk factor for development of mental diseases, including
Conclusions.– In this study of marginalized persons, feasibility and schizophrenia.
validity were confirmed for brief VAS scales to determine mental Objective.– To study effects of long-term antipsychotic therapy with
health. Findings also highlight the role of neuroinflammation the risperidone on cytokine levels in schizophrenic patients.
symptoms etiology in high-risk groups. Self-related energy corre- Methods.– We examined 46 schizophrenic patients, who used neu-
lates with decreased inflammation. roleptic risperidone more than 6 months before admission in the
Disclosure of interest.– The authors have not supplied a conflict of hospital as the main anti-recurrence therapy. Persons aged 18–65
interest statement. years with length of the follow-up of the disease ≥1 year were
included whose state met criteria of schizophrenia according to
ICD-10. Mitogen-induced, spontaneous production and serum lev-
els of cytokines (IL2, IFN-␥, IL-4, TNF-␣) were identified with use of
kits for enzyme-linked immunosorbent assay (ELISA). The research E-PP0886

was carried out in two points: first – at admission, second – by week The role of the anthranilic acid in
6 of the treatment.
depression in adolescent with chronic
Results.– Before the beginning of use of risperidone significantly
decreased level of mitogen-induced production by mononuclear
hepatitis c six during pegylated
cells of INF␥ (p = 0,0001), IL4 (p = 0,015) and TNF␣ (p = 0,002), interferon-␣ 2a treatment
high levels of spontaneous production of INF␥ (p = 0,03) and T. Pawlowski1* , D. Pawlak2 , M. Inglot3 , M. Zlewska3 , K.
TNF␣ (p = 0,002), as well as elevation of spontaneous production Malyszczak1
1 Wroclaw Medical University, Division of Psychotherapy and
and serum concentration of IL2 (p = 0,0001 and p = 0,0001) were
revealed. In the process of therapy tendency to decrease in spon- Psychosomatic Medicine Department of Psychiatry, Wroclaw, Poland;
2 Medical University of Bialystok, Department of Pharmacodynamics,
taneous production of INF␥ and increase in its serum level was
revealed. Bialystok, Poland; 3 Wroclaw Medical University, Department of
Conclusions.– Thus, substantial dysfunctions of the cytokine system Infectious Diseases, Hepatology and Acquired Immune Deficiencies,
were revealed in the course of anti-recurrence therapy with atyp- Wroclaw, Poland
ical neuroleptic risperidone. The findings confirm the hypothesis
that ethiopathogenesis of schizophrenia includes immunopathol-
Background and aims.– The aim of this study was to determine
ogy with dysfunction of IL-2/ INF␥-system.
the influence of the pegylated interferon alfa-2a (PEG-IFN-␣2a)
on tryptophan metabolism along the kynurenine pathway during
interest statement.
24 weeks of treatment and assessing the relashionship between
tryptophan metabolites’ and depressive symptoms.
E-PP0885 Methods.– We evaluated 101 patients with chronic hepatitis C
treated with PEG-IFN-␣2a, so as to determine the activation of
Clinical-immunological predictors of indolamine 2,3-dioxygenase (IDO), tryptophan (TRP) and their
formation of protracted course of metabolites’ concentrations/levels: kynurenine (KYN), kynurenic
somatoform disorders acid (KYNA) and anthranilic acid (AA). We also determined: tyro-
V. Nikitina1* , O. Lobacheva1 , A. Kostin2 , E. Epanchintseva3 , M. sine (Tyr), valine (Val), isoleucine (Ile), leucine (Leu), phenylalanine
Axenov2 (Phe) which are referred to as competing amino acid (CAA). The
1 Mental Health Research Institute, Tomsk National Research Medical
subjects were evaluated before and after weeks 2, 4, 8, 12, 24 of the
Center- Russia, Department of Psychoneuroimmunology and treatment. We assessed the relationship between TRP metabolites’
Neurobiology, Tomsk, Russia; 2 Mental Health Research Institute- and diagnosis of depression and severity of depressive symptoms
Tomsk National Research Medical Center, Russia, Borderline States measured by the MADRS.
Department, Tomsk, Russia; 3 Mental Health Research Institute, Results.– IDO activity and the total MADRS score were significantly
Tomsk National Research Medical Center, Russia, First Clinical increased in comparison to baseline whereas TRP concentration
Psychiatric Unit, Tomsk, Russia declined during the treatment. IDO activity, TRP concentrations,
TRP availability and AA concentrations were significantly associ-
ated over time with the total MADRS score (␤ = 0.07 P = 0.004, ␤ =
Background and aims.– In somatoform disorder pathogenesis the −1.01 P < 0.001, ␤ = −0.50 P = 0.001 and ␤ = 0.28 P = 0.006 respec-
leading role is played by alterations of neurohumoral regulation tively). Decreased TRP availability was associated with diagnosis of
of functional state of inner organs, including imbalance of the depression in the 12th week of PEG-IFN-␣2a treatment (OR = 2.92
immunity system. This leads to formation of secondary immune 95%CI = (1.01, 8.42) P = 0.032) whereas increased AA concentrations
deficiency, which complicates clinical picture of somatoform dis- was associated with diagnosis of depression in 24th week of treat-
orders, promotes their protracted course. ment (OR = 3.59 95%CI = (1.18, 10.93) P = 0.024)
Methods.– Examination of 54 patients (mean age 40.00 ± 8.74 years) Conclusions.– The anthranilic acid can be implicated in the patho-
with somatoform disorders (F45.0) was conducted. According to physiology of depressive episodes during Pegylated Interferon-␣
length of disease patients were divided into two groups: length 2a Treatment.
of disease < 3 years (n = 25); 2 - unfavorable, protracted course of Disclosure of interest.– The authors have not supplied a conflict of
somatoform disorders, length of disease ≥3 years (n = 29). Immuno- interest statement.
logical investigation included the phenotyping of subpopulations of
immunocompetent cells with use of flow cytometry.
Results.– Immune status of patients with protracted course of E-PP0887
somatoform disorders in comparison with patients of group 1
Investigation of immunological
was characterized by lower number of T-lymphocytes (CD3+)
(p = 0.0008), cytotoxic T-lymphocytes (CD3+CD8+) (p = 0.0005), parameters in the first episode
higher number of lymphocytes with markers of late activation psychosis patients
(CD3+HLADR+) (p = 0.0087). T. Sarikavak1* , Ö. Özgür1 , D. Isman Haznedaroglu1 , N. Mete
Conclusions.– Dysfunction of neuroimmune mechanisms of regula- Gökmen2 , A. Sin Zerrin2 , H. Elbi1
1 Ege Üniversitesi Medicine Faculty, Psychiatry Department, Bornova,
tion should be considered as peculiar characteristics of a similar
psychobiological process in somatoform disorders. Dysfunctions Turkey; 2 Ege Üniversitesi Medicine Faculty, Allergy and Immunology
of immune protection are unfavorable factors contributing to Department, Bornova, Turkey
the formation of somatoform disorders, their protracted course
and polymorphism of clinical symptoms. Summated decrease in
number of mature T-lymphocytes, cytotoxic T-lymphocytes, and
Introduction.– Schizophrenia and disorders in this spectrum are
increase in number of lymphocytes with markers of late activation
psychiatric disorders that start at a young age. Current approaches
allowed considering them as predictors of formation of protracted
about etiology are that immunologic and autoimmune factors play
course of somatoform disorders at earlier stages of the disease and
a role in the etiology and course of the disease.
conducting targeted psychopharmacological measures.
Objectives.– This study was planned to investigate the immuno-
logic baseline of first-episode psychosis patients, to determine their
interest statement.
association with symptom content and severity, and to identify current and future demands in the domain of hospice and palliative
markers for prognostic-predictive screening. care.
Methods.– 29 patients with short-term psychotic disorder or Disclosure of interest.– The authors have not supplied a conflict of
schizophreniform disorder according to DSM-IV and 25 healthy interest statement.
controls were studied. Once volunteer approvals were received,
SCID-1 structured interview was performed for diagnostic valida-
tion, PANSS and BPRS was applied for disease severity. Blood was E-PP0889
taken for the immunological parameters to be worked after the Barriers for conjugal violence
interviews. screening by general practitioners in
Results.– No statistically significant difference was found between
sfax (Tunisia)
the patient and control groups in terms of age, gender, duration of
D. Maroua* , N. Charfi, S. Najjar, M. Maalej, S. Omri, R. Feki, L.
education. Mean total score of PANSS was 97.2 ± 11.15 and BPRS
Zouari, J. Ben Thabet, M. Maalej
score was 49.75 ± 13.11. Sensitive CRP, Ferritin, Serum Amyloid
Psychiatry C Departement of the University Hospital Hedi Chaker
A, IgG, IgM, IgA, IgE, C4, Vitamin A, Vitamin E, Anti-Tiroglogulin
Hospital University 3029 Sfax Tunisia, Psychiatry C Departement of
and Anti Thyroperoxidase were significantly different between the
the University Hospital Hedi Chaker Hospital University 3029 Sfax
groups. BPRS score were significantly correlated with Copper, Vita-
Tunisia, Sfax, Tunisia
min A and Vitamin E, PANSS Positive Symptoms Sub-Scale score * Corresponding author.
with Serum Amyloid A and Anti Thyroglobulin, PANSS Negative
Symptoms Sub-Scale score with Serum Amyloid A and Sensitive Background and aims.– Statistics indicate that one in four women
CRP. will be a victim in his lifetime of physical, psychological, verbal,
Conclusions.– Our study found significant differences in immuno- sexual or economic violence. General practitioners are increas-
logical parameters between first-episode psychosis patients and ingly being encouraged to screen for conjugal violence, which is
healthy controls. Some of these differences are also correlated with a serious health problem. In this study, we highlighted what a gen-
clinical symptoms. Similar studies may reveal relationships with eral practitioner knows about conjugal violence and the difficulties
endophenotypes and immunological parameters. encountered in the screening.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– It was a cross-sectional study. A detailed questionnaire
interest statement. on practices relating to conjugal violence was sent by e-mail to 180
general practitioners. The e-mail contained a letter to explain the
objective of the study and a link to the questionnaire.
E-PP0888 Results.– On average, doctors detected 2.8 women victim of conju-
Correlation of euthanasia attitude of gal violence during the year. Physical (55%) and verbal (40%) were
physicians with their level of the most represented kind of violence. All the participants were
religiosity aware of the importance of the problem and knew its suggestive
M. Malliarou1* , K. Vourdami2 , S. Kotrotsiou1 , T. Paralikas1 , P. symptoms of bruise, ecchymoses, joint pain and anxiety disorder.
Sarafis3 A routine screening of conjugal violence wasn’t a common prac-
1 TEI of Thessaly, Nursing, Larissa, Greece; 2 Hellenic Open University, tice among the participants. The main difficulties addressed were:
School of social sciences, Patra, Greece; 3 Cyprus University of negative representations of victims by doctors 35.5%), time and
Technology, Nursing, Limassol, Cyprus availability problems (22.3%), lack of understanding of the network
* Corresponding author. of stakeholders (16.2%), lack of medical training in this area (15%)
and shame and taboo related to this issue (11%).
Background and aims.– “Suffering” patients’ wishes concerning Conclusions.– The negative social representation of conjugal vio-
hastening their own death by means of euthanasia or physician- lence and the lack of training in this regard seem to be the more
assisted suicide, raised by personal, psychological, social and other important barriers for the detection of conjugal violence by the gen-
motives, are becoming increasingly common. eral practitioners. Those factors should be taken into account when
Aim of this study is to investigate the correlation between Greek planning educational programs on this issue.
physicians’ attitudes and beliefs towards euthanasia and physician- Disclosure of interest.– The authors have not supplied a conflict of
assisted suicide with their level of religiosity. interest statement.
Methods.– The final sample consisted of 93 specialized physicians,
whose attitudes on euthanasia were evaluated using Euthanasia
Attitude Scale while religiosity was evaluated with Daily Spiritual E-PP0890
Experience Scale. Data was analyzed using SPSS version 22 (2 -test, Measuring the cognitive and somatic
ANOVA, linear regression analysis). dimensions of anxiety: psychometric
Results.– Greek physicians generally disapprove of euthanasia
analysis of state-trait inventory for
which is irrelevant to their age (p = 0.156) or gender (p = 0.957). On
the contrary, physicians’ attitudes and beliefs correlate with their cognitive and somatic anxiety (STICSA)
specialty (p = 0.037), years of professional experience (p = 0.037), C. Figueiredo1 , A. Mendes2 , F. Barros2,3 , D. Moura4,5* , N.
as well as the number of terminally ill patients they cared for Madeira4,5 , C.F. Silva2,3 , S.C. Soares2,3
1 University of Aveiro, Govcoop, Aveiro, Portugal; 2 University of
and died within the last 12 months (p = 0.016). Oncologists, those
with longer clinical experience and those who treat more end- Aveiro, CINTESIS.UA- Department of Education and Psychology,
stage patients are more strongly opposed to the above practices. Aveiro, Portugal; 3 Instituto Superior de Psicologia Aplicada ISPA,
Religiosity, is associated with a negative attitude toward euthana- William James Research Center, Lisboa, Portugal; 4 Centro Hospitalar
sia (p < 0.001). The majority of physicians (64.5%) are in favor of e Universitário de Coimbra CHUC- Portugal, Department of
legalizing euthanasia. Requests for withholding or withdrawing Psychiatry, Coimbra, Portugal; 5 Faculty of Medicine, University of
ineffective life-prolonging treatments have been sent to 61.3% of Coimbra, Institute of Psychological Medicine, Coimbra, Portugal
the physicians, whereas only 9.7% of them have responded to such
requests. Background and aims.– The State-Trait Inventory for Cognitive and
Conclusions.– Greek physicians are opposed to euthanasia and Somatic Anxiety (STICSA) is a self-report instrument that assesses
physician-assisted suicide and they require the acquisition of com- both cognitive and somatic dimensions, regarding trait and state
petencies in end-of-life care in order to fulfill their profession’s
anxiety. This assessment fosters a more accurate profile of the Disclosure of interest.– The authors have not supplied a conflict of
symptomatology, compared with the mostly used scales (e.g., STAI, interest statement.
CSAQ). Given the high prevalence of anxiety and its implications in
well-being, STICSA may enable more tailored clinical interventions.
The authors aim to provide empirical evidence on psychometric
qualities of a new instrument to assess anxiety, in the Portuguese E-Poster Presentation: Psychopharmacology and
general population. Pharmacoeconomics - Part I
Methods.– A research protocol, in a survey format, was adminis-
tered to 1123 Portuguese adults, living in Portugal. Participants’
ages ranged from 18 to 78 years old (M = 21.82; SD = 4.67), 65.3% E-PP0892
being females. Clozapine double induced
Results.– An Exploratory Factorial Analysis (Principal Axis Fac-
neutropenia. shall we rechallenge?
toring) supported a two-factor model, both for trait and state
P. Argitis1* , A. Kourti1 , S. Karavia1 , C.M. Platsa1 , K. Pachalidis2 , D.
conditions of anxiety (explaining 38.15 and 44.06% of common
Gardelis1 , A. Karampas3
variance, respectively). As in the original scale, the items clearly 1 General Hospital of Corfu, Psychiatric, Corfu, Greece; 2 Psychiatric
separated cognitive and somatic symptoms, although three were
Hospital of Thessaloniki, Psychiatric, Thessaloniki, Greece; 3
excluded due to low factor loading (two in the state and one in the
University Hospital of Ioannina, Psychiatric, Ioannina, Greece
trace dimensions). The four factors showed good reliability (Cron- * Corresponding author.
bach alfa ranging from .91 to .79). Moreover, convergent validity
analysis indicated that cognitive and somatic dimensions presented Background and aims.– Clozapine is an atypical neuroleptic
the expected levels of association with anxiety (STAI) and depres- acknowledged as the gold standard for treatment-resistant
sion (DAS21). schizophrenia, reaching a response rate of 30 to 60%. Clozapine’s
Conclusions.– The results supported that STICSA is an effective manifold bounding affinities account for both the drug’s pharma-
and robust instrument to assess cognitive and somatic anxiety, cological properties and adverse effects, with clozapine induced
considering the state and trait dimensions. Implications on the neutropenia or agranulocytosis (3% and 1% respectively) being
importance of a brief and more discriminant measure of anxiety the main reason for the cessation of administration. Evidence
are discussed. and guidelines suggest to consider rechallenging after clozapine
Disclosure of interest.– The authors have not supplied a conflict of induced neutropenia incidence in TRS, but question remains what
interest statement. treatment should be used following double induced neutropenia.
Methods.– We searched thoroughly the international literature
using google scholar and PubMed for reports of clozapine rechal-
E-PP0891 lenge after double induced neutropenia.
Normative data for the dms 48 in Results.– Only one case of clozapine rechallenge after double
Tunisian population induced neutropenia is described in international literature. Ref-
B. Nadia1* , N. Farhat2 , H. hajkacem2 , O. hdiji2 , S. sakka2 , M. erence is made to a combined clozapine and lithium (0.33 mEq/L)
dammak2 , C. Mhiri2 administration following double induced neutropenia, with
1 University Habib Bourguiba Hospital, Neurology, Sfax, Tunisia; 2 lithium’ s addition justified by its ability to cause true leukocytosis.
University Hospital Habib Bourguiba, Neurology, Sfax, Tunisia Conclusions.– Rechallenging clozapine following neutropenia inci-
* Corresponding author. dence is a difficult decision for most mental health practitioners.
One has to bear in mind both the benefits and the hazards of such
Background and aims.– The DMS 48 is a visual recognition mem- a decision. However, the reoccurrence of neutropenia seems to be
ory test designed to detect memory changes in early Alzheimer’s prohibitive for the majority of psychiatrists in terms of re-initiating
disease (AD). The aim of this study is to establish the effects of age, clozapine. The absence of efficient treatment options for this less
gender and education and to provide normative data in the Tunisian favoured proportion of patients, as well as the optimum effects of
population. clozapine on both positive and negative symptoms, could be good
Methods.– We have evaluated 342 cognitively healthy volunteers enough reason to try rechallenging even after the second neutrope-
(54.97% male and 45.02% women), divided into 4 age groups nia incidence. Nevertheless, more research is needed in order to
(40–49, 50–59, 60–69 and 70 years) and into 3 educational level make this venture a less ominous option for practitioners.
(I: primary, II: secondary and III: superior). All participants had an Disclosure of interest.– The authors have not supplied a conflict of
MMSE > 24. DMS 48 consists of a series of 48 (target) pictures that interest statement.
the subject memorizes incidentally, then 2 sets of 48 pairs of pic-
tures, each pair consisting of the target and another picture that the
subject never saw called “distractor”. No distractor is repeated in E-PP0893
the 3 sets. The performance for each SET (1 and 2) was expressed Atypical form of neuroleptic
as a percentage of correct answers. We measured the durations in
malignant syndrome from long-acting
seconds of the different phases: encoding, immediate recognition
and recognition at 1 hour. injectable paliperidone: a case report
Results.– The mean age was 57.20 years (±10.65). All scores were P. Argitis1* , A. Kourti1 , C.M. Platsa1 , S. Karavia1 , N. Pagkratis1 , X.
significantly influenced by age and education, without influence of Chandrinos1 , A. Karampas2 , P. Platari2 , Z. Chaviaras1
1 General Hospital of Corfu, Psychiatric, Corfu, Greece; 2 University
gender. Performance was better in younger and subjects belong-
ing to level III. Maximum score (48/48) for SET 1 obtained by Hospital of Ioannina, Psychiatric, Ioannina, Greece
3.21%(11/342) and for SET 2 obtained by 17.25%(59/342). Longest
durations in seconds for encoding was 448, for immediate recog- Background and aims.– Neuroleptic malignant syndrome (NMS) is a
nition was 468 and for recognition at 1 hour was 454. Scores were potentially lethal condition associated with typical antipsychotics.
expressed in terms of age and socio-educational level. On the contrary, it is not a common side effect of the atypical class
Conclusions.– Our results were comparable to the previous studies. of antipsychotics.
his work finds its interest to provide normative data for Tunisian
population.
Methods.– We present you the case of a patient with chronic E-PP0895

schizophrenia who presented an atypical form of NMS after being Genetically determined gaba
treated with long-action injectable paliperidone.
metabolism is associated with
Results.– A.V. was a patient with chronic schizophrenia who,
for almost one year, was treated with long-action injectable
benzodiazepines’ effectiveness in
paliperidone 150 mg, without presenting any side effects from the alcohol withdrawal syndrome
medication. On the eighth month of treatment, the day after the A. Bryleva1* , D. Ivashchenko1 , M. Solov’eva2 , A. Kibitov2 , M.
injection, the patient featured altered consciousness level, rigidity, Zastrozhin3 , E. Bryun1 , D. Sychev1
1 Russian Medical Academy of Continuous Professional Education,
low-grade fever and low scale hypertension. Tests were performed
that indicated high CPK and CRP, without any other signs of infec- Department of Personalized Medicine, Moscow, Russia; 2 Serbsky
tion. We completed the examinations needed to exclude other National Medical Research Centre on Psychiatry and Addictions,
pathological causes for her condition and we concluded that it Laboratory of Molecular Genetics, Moscow, Russia; 3 Moscow
was attributed to the long-acting injectable paliperidone. Subse- Research Practical Center of Addiction medicine, Department of
quently, we treated her extrapyramidal symptoms with biperiden Personalized Medicine, Moscow, Russia
at a dosage of 4 mg per day. As a result, her condition was improved
and all the symptoms recessed after CPK declined.
Background and aims.– There are two isoforms of glutamate acid
Conclusions.– Even if there is an overlap of many of the symptoms
decarboxylase GAD67 and GAD65, which are encoded by the genes
mentioned above with potential side effects from atypical neu-
GAD1 and GAD2. The genotype and allele frequencies of rs2236418
roleptics, NMS cannot be excluded from the differential diagnosis,
(GAD2) are associated with alcohol dependence, in which the G
especially since our patient was treated with paliperidone for a
allele was related to increased risk.
sufficient amount of time before presenting the symptoms. What
The aim is to evaluate associations of GAD2 rs2236418 polymor-
is more, studies have shown that SGAs might, not so frequently,
phism with effectiveness of benzodiazepine tranquilizer in patients
cause a less severe form of NMS. One could characterize it as an
with AWS.
atypical form of NMS.
Methods.– 102 male patients with non-complicated AWS (F 10.3
by ICD-10) were involved into the study in 24 hours after their
interest statement.
admission to hospital. Each participant was prescribed benzodi-
azepine tranquilizer phenazepam and was observed for 6 days.
E-PP0894 Blood samples (5 ml of venous blood) were analyzed to detect GAD2
rs2236418 (A > G) polymorphisms by real-time PCR. The severity of
Capgras syndrome treated with AWS was evaluated with visual-analogue scale (VAS).
aripiprazole in postmenopausal Results.– Distribution of genotypes rs2236418 (GAD2 gene – GAD65
woman with a history of vascular enzyme) corresponded to the Hardy-Weinberg equilibrium (Chi-
dementia and pituitary adenoma square = 1.085, p > 0.05). There were 72 AA homozygous, 29 - AG
A. Baluna genotype and 1 - GG. Homozygous AA were noted a greater severity
Montefiore Medical Center, Psychiatry, Bronx, NY, USA of AWS according to VAS severity scale at admission (2.69 ± 1.79 vs
Background and aims.– We report a case of a patient with a history of 3.52 ± 2.07 degrees, p = 0.042), but they also demonstrated faster
Vascular Dementia and presentation of Capgras Syndrome treated dynamics of severity relief (-2.91 ± 2.24 vs −1.78 ± 2.82, p = 0.034).
with aripiprazole. Conclusions.– A connection between the gene polymorphism GAD2
Methods.– A postmenopausal female with a history of dementia, rs2236418 and the effectiveness of AWS pharmacotherapy by ben-
pituitary adenoma, and cerebrovascular accidents was brought to zodiazepine tranquilizers has been found. Patients with genotypes
Emergency Room by her husband due to worsening paranoia. She AA and AG had more severe AWS at admission, but greater benzo-
believed her husband was a “strange mean man” trying to assume diazepine’s effectiveness than G-allele carriers.
the identity of her husband whom she believed had passed away; Disclosure of interest.– The authors have not supplied a conflict of
she reports the intruder had poisoned her food for the last year. interest statement.
On initial evaluation, she is disheveled, calm, awake, alert, ori-
ented to person, location, date, year with poor insight as to why
she is admitted. She responds to internal stimuli and states she E-PP0896
sees angels. Speech is fluent, dysarthric and hypophonic; repetition Vafidemstat, a new approach to treat
intact; naming intact; she follows 4-step commands; concentra- aggression in central nervous system
tion intact, recall 4/4, answers questions appropriately. She has disorders: a clinical study reimagine
decreased visual fields on Left > Right temporal areas. M. Ferrer1 , R.A. Bullock2* , V. Richarte1 , L. Gisbert1 , M. Valverde1 , T.
Patient was started on home medications of Hydrocortisone, Ramos1 , M. Bifano1 , T. Maes2 , C. Buesa2
Levothyroxine, and Chlorthalidone. She was not able to tolerate 1 Valle D’Hebron, Medicine, Barcelona, Spain; 2 Oryzon Genomics SA,
trials of olanzapine or fluphenazine due to weight gain and urinary Medical, Barcelona, Spain
incontinence, respectively. * Corresponding author.
Results.– Aripiprazole was started and titrated to 10 mg. After one
month of treatment, patient no longer endorsed paranoia or delu- Background and aims.– Basket trials are used in oncology, in an
sional content, was notably euthymic, and requested to return open-label adaptive design, to prove concept and target best
home with her husband. responders. They are uncommon in CNS. Vafidemstat (ORY-2001) is
Conclusions.– We present a case of a woman in her mid-50s with a a small, brain penetrant molecule that modifies transcription in the
history of Vascular Dementia, Pituitary Adenoma and Capgras Syn- brain through epigenetic effects. A particular interest is aggression.
drome. Delusional content and after a 1month trial of aripiprazole In the Alzheimer’s SAMP8 mice model, Vafidemstat reverts their
10 mg. strong aggressive behaviour and corrects the abnormal response
Disclosure of interest.– The authors have not supplied a conflict of to stress of immediate early genes in the prefrontal cortex. If this
interest statement. represents a phenotype where aggression manifests as an exagger-
ated response to stress, a basket design is conceivable using a single
compound.
Aim.– To use Vafidemstat to treat aggression in patients with E-PP0898

Alzheimer’s disease, Lewy Body Dementia, autistic spectrum dis- Patient profile with long-acting
order (ASD), attention deficit hyperactivity disorder (ADHD) and
antipsychotic treatment in our area
borderline personality disorder.
Methods.– Six patients (age 18–85) per disorder will receive- and use of adjuvant oral antipsychotic
Vafidemstat for eight weeks in a phase IIa open-label study treatment
(REIMAGINE). Entry is based on significant or persistent agitation A. Fernandez Galvez* , M.J. Valdes Florido, A. Piña Baena, M.
or aggression that was disruptive to patient’s daily living or put the Vazquez Delgado1 , A. Perez Romero, C. Muñoz Cauqui
patient in harm’s way for at least 3 days per week for at least 4 Hospital Universitario Virgen Macarena, Psiquiatria, sevilla, Spain
weeks prior to screening.
Results.– Results on the first cohorts will be presented in April.
Background and aims.– The introduction of long-acting antipsy-
Conclusions.– This is a new approach in treating aggression, which
chotic treatment (LAI) represents an improvement in Mental
importantly does not involve sedation or unpleasant side effects.
Health. 1,2.
CNS Basket trial methodology will explore a) if one targeted
Describing the profile of the patient being treated with LAI in our
approach can work across multiple conditions b) whether the con-
area, and the use of monotherapy versus polytherapy.
cept of disease transcription phenotyping will increase treatment
Methods.– Retrospective observational study at the Virgen
options in CNS/psychiatry studies.
Macarena Hospital. We analyzed the profile of the patient with LAI
from 2012 to 2018 (n = 113), making a descriptive comparison, in
interest statement.
relation to the injectable treatment and the use of oral antipsy-
chotics.
E-PP0897 Results.– We have detected 113 subjects with LAI in our area.
30.09% are women, and 69.91%, are men. The average age is
Psychosis induced by levodopa 44.98 years, with the main diagnosis being schizophrenia (52.21%).
M. Costa* , R. Mendes de Paula Pessoa, G. Elias Correa de Oliveira,
38.05% had monthly depot paliperidone, 28.32% depot aripipra-
N. Mota de Souza Chagas, M.C. de Morais Faleiros, A. Sponholz
zole, 30.57% paliperidone depot quarterly, and 2.65% others, such
Junior, C. Marta Del-Ben
as zuclopentizol or fluphenazine. 58.41% did not have an additional
Universidade de São Paulo, Neurociências e Ciências do
oral antipsychotic, with polytherapy at 0.88%. The most frequent
Comportamento, Ribeirão Preto, Brazil
* Corresponding author. previous treatments were paliperidone depot monthly (24.59%,
76.67% were changed to paliperidone quarterly), oral olanzapine
Background and aims.– The hypothesis that dysfunction of (15.57%) and risperidone depot fortnightly (12.30%).
dopaminergic mechanisms are central to the etiology of psychotic Conclusions.– The typical patient with LAI in our area is a man of
disorders has been one of the most enduring theories in psychia- about 45 years with schizophrenia, without oral adjuvant treat-
try. Several studies report adverse events of therapeutic medicines. ment. Most clinical guidelines discourage using polypharmacy
Levodopa is widely used for Parkinson’s disease, however adverse with antipsychotics, assuming the possible potentiation of adverse
events such as psychosis represent disabling effects of treatment. effects and interactions. Nevertheless, it is a widespread practice.
Report the clinical progression of a patient who underwent lev- In our sample, the low percentage of polytherapy, in line with clin-
odopa treatment for suspected case of Parkinsons’s disease and ical evidence, is an interesting fact to highlight. This demonstrates
developed psychosis. an adequate and responsible use of LAI.
Methods.– Review of medical records from patient between August Disclosure of interest.– The authors have not supplied a conflict of
2016 and October 2018. interest statement.
Results.– Men, 68 years old, diagnosed with Epilepsy after trau-
matic brain injury (TBI) since 2013, taking valproic acid, began
E-PP0899
follow-up in extrapyramidal diseases speciality due to onset of
asymmetric upper limb tremors. Primarly, it was hipothetized Can testosterone administration
parkinsonian syndrome, then levodopa was introduced in August trigger aggressive behavior in a
2016. He evolved with persecutory delusions, auditory hallucina- patient with sensitive traits? case
tions, behavioral disorganization and heteroaggressiveness, with
report and literature review
need for hospital admission, and, later, institutionalization. Diag-
I. Figueiredo1 , T. Ferreira1 , F. Viegas1 , F. Ferreira1
nostic hypotheses of psychotic disorder secondary to TBI, levodopa, 1 Hospital Prof. Doutor Fernando da Fonseca, Department of
or Parkinson’s disease with psychotic symptoms were made. Queti-
Psychiatry, Amadora, Portugal
apine was introduced and other medications were maintained. Due * Corresponding author.
to side effects, the patient suspended on her own valproic acid and
levodopa, presented total remission of symptoms 3 months before Background and aims.– Testosterone has been firmly associated
the suspension, with return to previous functionality. with aggression in several species, although evidence linking
Conclusions.– By itself, a rise in dopamine levels does not necessarily baseline testosterone concentrations and aggressive behavior in
have to lead to psychotic episodes. Besides, in studies with different humans is weak. Recent experimental work suggests that testos-
medicines within the therapeutic class - dopaminergic agonists -, terone exogenous administration has a central role in modulating
adverse effects appear to have diferential lag times between the aggressive behavior, possibly by regulating threat-related neural
medicine being marketed and suspicion of a causal link. circuits. Our aim is to present a clinical case of a patient with an
Disclosure of interest.– The authors have not supplied a conflict of increase of aggressiveness in relation with exogenous testosterone
interest statement. administration.
Results.– A 62-years-old man, with previous sensitive and impul-
sivity traits, and complains of ango-depressive symptoms since
January/2017, began depot-testosterone treatment in April/2017
because of erectile dysfunction. During treatment, he identified
heightened irritability, emergence of explosive outbursts of anger,
and intensification of infidelity delusion. The patient also noted
a worsening of the ango-depressive symptoms, and wound up properties through glutathione production, anti-inflammatory
consulting a psychiatrist in July/2017. Despite therapeutic adjust- properties and modulation of the glutamatergic and dopaminergic
ments, symptoms worsened and in December/2017 he assaulted systems of neurotransmission may be linked to its results. More-
his wife, and ended up being committed to the psychiatric ward. At over, NAC is low-cost and has benign side-effect profile.
that time, serum values of testosterone were normal. His neuropsy- Theme review on the available evidence regarding the potential
chological evaluation suggested a “subcortical cognitive defect, therapeutic effects of NAC in several disorders in Psychiatry.
with particular frontotemporal defect”. Methods.– A literature search was performed on PubMed database
Conclusions.– This patient, with chronic characteristics of sensi- using the keywords “N-acetylcysteine”, “psychiatric disorders”,
tivity and impulsivity, presented ango-depressive symptoms and “glutamate”, “schizophrenia”, “bipolar disorder”, “obssessive-
an infidelity delusion. It’s possible that either testosterone sup- compulsive disorder”, “other related disorders”.
plementation, cognitive defect, or both, potentiated his aggressive Results.– Pharmacotherapy remains inadequate for many patients,
behaviour. Testosterone augmentation is progressively being used therefore there is an urgent need for alternative pharmacological
as a pharmacologic treatment to restore physical and sexual vital- strategies. Promising results were found in trials testisg the use of
ity in aging men. This clinical case is relevant due to the possible NAC, mainly as an add-on treatment, in cannabis use disorder in
role of exogenous testosterone in the increase of aggressiveness. youg people, depression in bipolar disorder, negative symptoms in
Disclosure of interest.– The authors have not supplied a conflict of schizophrenia, and obssessive-compulsive related disorders.
interest statement. Conclusions.– Encouraging results have been demonstrated, still
there is a need for further studies to evaluate its mechanism of
action, appropriate dose range, duration of treatment and efficacy.
E-PP0900 Disclosure of interest.– The authors have not supplied a conflict of
Psychiatric side effects of natalizumab interest statement.
therapy in patients with relapsing
remitting multiple sclerosis E-PP0902
A. Ghariani1* , M. Damak1 , A. Nasri2 , N. Farhat1 , I. Kacem2 , R.
Gouider2 , C. Mhiri1
Lithium: possible role in the
1 Habib Bourguiba Hospital and LR-12-SP-19, Neurology, Sfax, prophylaxis of alzheimer’s disease
Tunisia; 2 Razi Hospital and UR12SP21, Neurology, Tunis, Tunisia D. Goel
* Corresponding author. Southland Hospital, Mental Health- Addictions & Intellectual
Disability Directorate, Invercargill, New Zealand
Background and aims.– Natalizumab is currently used as a second- Background and aims.– Paradoxically, the use of lithium is declining
line disease modifying treatment (DMT) in relapsing remitting even as the evidence for its efficacy in the treatment and prophy-
multiple sclerosis (RRMS). It has shown its clinical and radiological laxis of bipolar disorder continues to grow. Bipolar patients treated
efficacy with good tolerance. However, natalizumab is not without with lithium are at significantly lower risk of developing dementia
risk and may be responsible for psychiatric disorders. even when manic symptoms do not completely abate. Given this
Methods.– This was a retrospective, descriptive and bicentric study context, is there a possible role for lithium in the prophylaxis of
since January 2012 until September 2017, held in the departments Alzheimer’s Disease (AD)?
of Neurology of two tertiary care University hospitals: The Habib Methods.– Comprehensive literature review of evidence indicating
Bourguiba University Hospital of Sfax in South Tunisia and Razi the efficacy of lithium in attenuating the conversion of mild cog-
University Hospital of Manouba in North Tunisia. We included 49 nitive impairment into AD, and related research indicating novel
patients diagnosed with RRMS according to Mc Donald criteria of uses for psychiatry’s aspirin.
2017 who received at least one perfusion of natalizumab. Results.– Lithium reduces risk of dementia in patients of bipolar
Results.– In our cohort, two patients (4,2%) had psychiatric symp- disorder, indicating a possible role in the treatment of neu-
toms. Progressive multifocal leukoencephalopathy (PML) was rodegenerative disorders like Alzheimer’s, despite incomplete
excluded in front of the absence of confluent lesions on cerebral MRI understanding of its mechanisms of action. Lithium-induced inhi-
and the negativity of JCV. The first patient developed behavioral bition of GSK3B hampers the formation of amyloid plaques and
issues at the first infusion of natalizumab. He received antipsy- neurofibrillary tangles, increases BDNF levels in patients with early
chotic drugs and natalizumab was definitively discontinued after AD, and reduces CSF P-tau in subjects with MCI who eventually do
three infusions. The evolution was marked by the improvement not convert to AD. This has obvious clinical implications in the pre-
of psychiatric signs. The second patient had a mood disorder and vention of AD. A recent meta-analysis addresses exaggerated fears
insomnia after 6 years of treatment. The diagnosed of major depres- regarding lithium toxicity and reaffirms its overall safety.
sive episode was made and she received an antidepressant drugs Conclusions.– Lithium’s declining use despite increasing evidence
with an improvement of his symptoms. regarding its efficacy and safety might be attributable to, inter alia,
Conclusions.– Our study confirmed the rarity of psychiatric side the pharmaceutical industry’s disinterest, misplaced fears regard-
effects in natalizumab therapy ranging from mood disorders to psy- ing toxicity, and inadequate training in its use. Apart from the
chotic manifestations. The occurrence of such symptoms in patients considerable evidence indicating Its possible prophylactic role in
taking natalizumab should first raise the possibility of PML, a major Alzheimer’s Disease, trials with this already approved drug will
life-threatening complication of natalizumab therapy in RRMS. reduce costs. This further strengthens the case for public health
Disclosure of interest.– The authors have not supplied a conflict of funded research in this crucial domain.
interest statement. Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
E-PP0901
N-acetylcysteine: what is going on?
L. Gil
Centro Hospitalar Psiquiátrico Lisboa, Clínica 6, Lisbon, Portugal
Background and aims.– N-acetylcysteine (NAC), a derivate of the
amino acid L-cysteine, has been an emerging as an interesting
add-on treatment in several psychiatric conditions. Its antioxidant
E-PP0903 Results.– We detected that with the increase of dose (0 mg p > 0.05,
Hyperammonemic encephalopathy 5 mg p < 0.01, 10 mg p < 0.01, 20 mg p < 0.01), and the duration (on
due to valproic acid: an unusual the 30th minute p < 0.001, in the 60th minute p < 0.001), the pain
threshold is decreased (figure 1)
complication
M.M. Gutiérrez Rodríguez* , C. Moreno Menguiano, F. García
Sánchez
Hospital Universitario de Móstoles, Psychiatry, Móstoles, Spain
Background and aims.– Valproic acid (VPA) is a drug commonly pre-

scribed in Neurology and Psychiatry. It is used for the treatment of
seizures, neuropathic pain, migraine headaches and also in differ-
ent psychiatric disorders. VPA can induce hyperammonemia but in
rare cases hyperammonemia may be clinically significant, resulting
in hyperammonemic encephalopathy due to valproic acid (VHE).
The aim of this work is to review the current knowledge about
hyperammonemic encephalopathy due to valproic acid.
Methods.– Literature sources were obtained through electronic
search in specialized databases with special focus in peer review
manuscripts during the last ten years.
Results.– Several studies have shown elevated ammonia levels in
a large percentage of asymptomatic patients on VPA. In some
subjects, hyperammonemia may be clinically significant, result-
ing in hyperammonemic encephalopathy, which may be severe. Figure 1. Diagram: the duration of the pain threshold on the 30th
The pathogenesis of hyperammonemic encephalopathy remains and 60th minutes.
unclear but there are different theories. Risk factors for the devel- Conclusions.– The results of our study suggest that vortioxetine can
opment of VHE include concomitant use of other antilepileptics decrease the pain threshold.
drugs, higher doses of the drug, carnitine deficiency and the pres- Disclosure of interest.– The authors have not supplied a conflict of
ence of congenital abnormalities of urea cycle. The treatment of interest statement.
VHE involves the suspension of the medication. Other measures
that can be beneficial include arginine, sodium benzoate, sodium
phenylacetate, and L-carnitine and in severe refractory cases dial- E-PP0905
ysis. Psychopharmacogenetic analysis in
Conclusions.– VHE is a serious disease that can lead to death. It can
the structure of a multifactorial
be reversed if an early diagnosis is made and the treatment of VPA
is discontinued. Physicians should be aware of this potential com- personalized approach to the patient
plication of VPA and check ammonia levels in patients taking VPA D. Kutovoy1* , N. Zakharova1 , I. Nizamutdinov2 , V. Ilinsky2 , A.
who present with alterations in mental or neurologic status. Reznik3 , G. Kostyuk4
1 State Healthcare Institution «Psychiatric Clinical Hospital 1 n. a.
interest statement. N.A. Alekseev of Healthcare Department of Moscow», The educational
center, Moscow, Russia; 2 Genotek, Ltd., Moscow, Russia; 3 Institute of
Medico Social Technology of the Moscow State University of Food
E-PP0904 Production, Head of Psychiatric Department, Moscow, Russia; 4 State
The effect of vortioxetine on Healthcare Institution «Psychiatric Clinical Hospital 1 n. a. N.A.
Alekseev of Healthcare Department of Moscow», Head doctor,
nociceptive system Moscow, Russia
A. Inaltekin1* , Y. kıvrak2 * Corresponding author.
1 Kafkas Unıversıty- Faculty of Medicine, Psychiatry, Kars, Turkey; 2
Kafkas Unıversity- Faculty of Medicine, Psychiatry, Kars, Turkey Background and aims.– The efficacy and safety of psychopharma-
cotherapy are one of the most discussed issues of psychiatry.
Prevalence rates of psychopharmacotherapy inefficiency are rel-
Background and aims.– Vortioxetine is an antidepressant agent. it
atively constant, and vary from 30% to 60–75%. Pharmacogenetic
was newly entered into the commercial use in Turkey and overseas
testing seem to be an useful approach to increase therapy efficiency
markets. Apart from antidepressant and anxiolytic effects, which
rate. Databases of genetic markers involved in pharmacokinetics
are the characteristics of many antidepressants, it has been shown
and pharmacodynamics are constantly updated, recommendations
that they also have an analgesic effect. The aim of this study is to
for genetic testing are provided in some drug labels. Psychopharma-
investigate whether vortioxetine has an analgesic effect or not. We
cogenetics is a promising area of work for the Alekseev Psychiatric
aimed to investigate the effect of vortioxetine on the nociceptive
Clinical Hospital №1.
system in mice.
Methods.– Using the ontology PsyGenCheck, a psychopharmacoge-
Methods.– We obtained the mice from the Experimental Animal
netic test was performed for 14 patients (10 men, 4 women, 18–40
Production and Research Center of Kafkas University. We created 4
years old) with a catamnesis 1–36 months after genotyping, on
groups with 40 mice by using 10 mice in each group. The distilled
customizedGlobal Screening Array microchips.
water was given to the first group, 5 mg / kg of vortioxetine was
Results.– The results of this analysis have been confirmed in practice
intraperitoneally administered to the second group, 10 mg / kg of
- the intolerance of some drugs has been revealed, the dosage of
vortioxetine was intraperitoneally administered to the third group
others has been adjusted.
and 20 mg / kg of vortioxetine was intraperitoneally administered
Conclusions.– Preliminary calculations indicate a reduction in the
to the third group. We put each mouse one by one on the hot plate
economic burden on the budget by about 2.5 times when conduct-
at the 30th and 60th minutes. We indicated the duration passed on
ing a test with high-performance genotyping. Due to the choice
the mice’s licking the hind legs or jumping as the pain threshold.
of the optimal dose of an individually suitable drug, compliance
increases, the duration of inpatient treatment decreases, there are Results.– Most of the patients didn’t present any side effect (61.30%).
no side effects that require additional examination and treatment, (22.67%) presented side effects, with headache being the most fre-
the probability of a positive response to the drug doubles, and the quently reported (10.7%), followed by nausea or dyspepsia and
duration of high-quality remission increases threefold. sexual dysfunction. Only seven patients (9.33%) discontinued the
Disclosure of interest.– The authors have not supplied a conflict of treatment because of side effects. Clinical response in 42.7% was
interest statement. good but partial, 13.3% had complete symptomatic remission, with
the rest being null (25.3%), and non-evaluated yet (18.7%). A 60%
of patients were satisfied or very satisfied with the treatment and
E-PP0906 only 24% were unsatisfied. The average dose of Vortioxetine was
The influence of antidepressants on 10 mg.
male fertility Conclusions.– Vortioxetine is a relatively safe drug, with few side
A. Leśnicka effects, many of which are transient and do not condition a drug
Agata Leśnicka ISPL, -, Gdańsk, Poland withdrawal (2). More than half of patients was satisfied with this
Background and aims.– Antidepressants are widely prescribed and treatment. We had a high percentage of partial but not complete
considered safe. It is common knowledge that they might cause response to the drug, which is not infrequent in depressive dis-
sexual dysfunction. Their safety during pregnancy and lactation is orders. Considering the average dose (10 mgs) we can think that
also gaining interest. However, their influence on paternal side of we may obtain a complete response in the future if we use higher
reproduction is yet not addressed in official characteristics. doses.
The aim of this review was to determine whether antidepressant Disclosure of interest.– The authors have not supplied a conflict of
intake threatens male fertility. interest statement.
Methods.– EBSCO and MEDLINE databases were searched using key-
words “sperm”+ “antidepressants”. 22 peer-reviewed articles were
found as a result. E-PP0908
Results.– Out of the body of research analyzed only 8 articles con- Analysis of factors that influence the
cerned human male subjects (1 literature review). Samples were compliance of psychiatric treatment
relatively small. 4 papers on human studies stated that oral admin- in patients with severe mental
istration of SSRIs leads to abnormal sperm morphology, decreased
disorders
motility, oligospermia and increase sperm DNA denaturation. 1
V. Muñoz Martinez* , I. Diaz Quero, B. Mata Saenz, A. Ramírez
study revealed just DNA denaturation. 1 claimed that amitripti-
García, F. García Lázaro, I. Morales Saenz, L. Beato Fernández
line might have some beneficial influence on sperm and 1 was a
Hospital General de Ciudad Real, Psychiatry, Ciudad Real, Spain
longitudinal study stating that taking antidepressants by fathers is * Corresponding author.
not associated with increased risk of intellectual disability, malfor-
mations of autism in the offspring. Remaining papers were mostly Background and aims.– Severe Mental Disorder (SMD) includes
studies on rodents and stated that exposure to antidepressants chronic illnesses, characterized by episodes of relapse, which
increases sperm DNA damage and causes abnormal morphology. entails certain cognitive and functional impairment that limit
Conclusions.– patients in aspects of daily life. Compliance is essential to make
1. Antidepressants might negatively influence human male fertility the impact of the disease as low as possible.
and patients should be warned about this. Objective.– To identify the factors related to compliance with treat-
2. RCT human studies are necessary to verify this effect. ment in patients with SMD in our unit.
3. Risk concerning fertility and suicidality should be well balanced Methods.– This is an epidemiological, analytic, retrospective study
while prescribing antidepressant. of patients included in SMD programme. The following variables
4. information on alternative treatment methods (e.g. CBT) should were collected: demographic data, diagnosis, treatment compli-
be provided to patients who are afraid to use antidepressants ance, regular psychiatrist and other professionals related to the
because of infertility threat. patient, assistance to rehabilitation center, day hospital and res-
Disclosure of interest.– The authors have not supplied a conflict of idential devices. SPSS 19.0 was used to analyze the data.
interest statement. Results.– Our sample includes 437 patients. 94.1% of the patients
comply with their treatment. No statistically significant results
were found when the relationship with following factors was
E-PP0907 analyzed: gender, residence location, regular psychiatrist, nursing
Analysis of side effects and clinical consultation, psychology consultation, assistance to rehabilitation
response in a sample of patients with center, day hospital and residential devices. 5.9% of the patients
vortioxetine abandoned their treatments, which previously were the following
M.J. Marquez Marquez* , I. Pans Molina, F. Peralta Gallego, C. ones, including long-acting injectable antipsychotics (LAI) (table 1):
Menéndez-Sampil Landa, A. Piña Baena, M.J. Valdes Florido Table 1. Sample: 437 patients.
Hospital Virgen Macarena, Psiquiatria, Sevilla, Spain
* Corresponding author. Oral antipsychotics 65.4%
Risperidone-LAI 3.8%
Background and aims.– Vortioxetine is an antidepressant approved Paliperidone palmitate-LAI 23.1%
Aripiprazole-LAI 7.7%
for treatment of major depressive disorder, also commonly pre-
scribed for generalised anxiety disorder, cognitive symptoms
related to depression, and geriatric depression (1). Conclusions.– It is essential to work with patients with SMD the
We analyzed the presence of side effects, the clinical response and adherence to treatment to achieve good compliance. This can
patient’s satisfaction with vortioxetine. reduce the impairment that these diseases cause at different lev-
Methods.– A descriptive study on a sample of 75 patients receiv- els. To do this, it requires a multidisciplinary approach. Probably
ing treatment with vortioxetine. We evaluated the presence of the absence of statistically significant relationship in our analysis
the most frequent side effects, the symptomatic response and the may be due to the small number of patients identified as patients
patient’s satisfaction. who have dropped out the treatment.
interest statement.
E-Poster Presentation: Psychopharmacology and monthly Paliperidone Palmitate (PP1M) on treatment continuation
Pharmacoeconomics - Part II and hospital stay in routine clinical practice.
Methods.– This was a naturalistic, 6-year mirror-image study exam-
ining retention & hospitalisation rates 3 years pre- and 3 years post
PP1M initiation.
E-PP0909
Results.– 173 consecutive patients were included. 120 (70%)
Clozapine and its safety in clinical patients had a primary diagnosis of schizophrenia and 53 (30%) had
practice other diagnosis. In total, 77% of patients continued PP1M for 1 year,
M. Obdržálková1* , K. Horská2 , H. Kotolová3 , P. Štrocholcová1 , L. 66% for 2 years and 55% for 3 years. In the schizophrenia group, 80%
Ustohal1 continued for 1 year, 70% for 2 years and 57% for 3 years.
1 Faculty of Medicine of Masaryk University and University Hospital
In the patients who continued with PP1M for 3 years (n = 95), the
Brno, Department of Psychiatry, Brno, Czech Republic; 2 FaF VFU mean number of hospital admissions decreased significantly from
Brno- Faculty of Medicine of Masaryk University and University 1.44 to 0.53 and the mean number of bed days from 93 to 29 bed
Hospital Brno, Department of Human Pharmacology and Toxicology- days per patient 3 years before and 3 years after PP1M initiation
Department of Psychiatry Brno, Brno, Czech Republic; 3 FaF VFU Brno, (P < 0.001). The schizophrenia group who continued for 3 years
Department of Human Pharmacology and Toxicology FaF VFU Brno, (n = 79) demonstrated similar statistically significant reductions in
Brno, Czech Republic number and length of admissions.
Conclusions.– PP1M had a significant impact on long term clinical
outcomes in terms of reduced hospitalizations and high continu-
Background and aims.– Clozapine represents an irreplaceable ther- ation rates in this naturalistic cohort. More than half of patients
apeutic strategy, particularly in treatment-resistant schizophrenia were still continuing on PP1M at 3 years after initiation. Number of
therapy, which, however, carries certain risk. The aim of the study admissions and bed days reduced by two thirds, while more than
was to evaluate frequency of clozapine adverse effects in patients half of patients had no admission during 3 years follow up.
with schizophrenia-spectrum disorders hospitalized at Depart- Disclosure of interest.– The authors have not supplied a conflict of
ment of Psychiatry, University Hospital Brno, during the period interest statement.
2012–2014.
Methods.– Data were evaluated retrospectively, out of total number
of 336 patients (285 patients with F200, F231, F232, and 51 patients E-PP0911
with F25), 62 patients (41 men and 21 women) were treated by
What is the role of weight gain and
clozapine.
Results.– Clozapine doses ranged from 100–700 mg/day in men, metabolic alterations in clozapine
150–600 mg/day in women, mean dose was approx. 300 mg/day. therapeutic drug monitoring?
Adverse effects of clozapine included tachycardia (50%), constipa- J.E. Pinzon Espinosa1* , M. Garriga2 , G. Anmella1 , A. Gimenez1 , M.
tion (34%), increased weight (15%), tiredness and blood dyscrasia, Brat3 , I. Grande2 , E. Vieta2 , M. Bernardo4 , C. García-Rizo4
1 Institute of Neurosciences. Hospital Clínic, Department of Adult
manifested as neutropenia in four patients, none presented agran-
ulocytosis. With lower frequencies were noted hypertension, Psychiatry and Psychology, Barcelona, Spain; 2 Biomedical Research
salivation, insomnia. Institute August Pi i Sunyer IDIBAPS. Network Center for Biomedical
Conclusions.– Although a relatively wide spectrum of adverse Research in Mental Health CIBERSAM. University of Barcelona.
events has been reported with high frequency, none of the adverse Bipolar Disorders Program., Hospital Clínic. Department of Adult
events led to clozapine discontinuation or was classified as severe. Psychiatry and Psychology, Barcelona, Spain; 3 Biomedical Research
The benefits of clozapine therapy undoubtedly outweigh the risks Institute August Pi i Sunyer IDIBAPS, Department of Neuroscience,
which can be reduced by close monitoring and adequate interven- Barcelona, Spain; 4 Biomedical Research Institute August Pi i Sunyer
tions combined with therapeutic strategies – e.g. betablockers for IDIBAPS. Network Center for Biomedical Research in Mental Health
tachycardia, dietary interventions, laxatives for constipation and CIBERSAM. University of Barcelona. Barcelona Clinic Schizophrenia
dietary measures for metabolic side effects together with pharma- Unit, Hospital Clínic. Department of Adult Psychiatry and Psychology,
cotherapy of dyslipidemia, pre T diabetes/diabetes or obesity. The Barcelona, Spain
most serious risk of clozapine therapy is agranulocytosis, occurring
with prevalence of 1–2%, regular blood screening as recommended
Background and aims.– Treatment with clozapine entails close drug
and early therapy can prevent cases of this life-threatening condi-
monitoring. Diverse variables and pharmacokinetic interactions
tion and eliminate the risk.
influence its plasma levels. To this date, the role of weight gain
by clozapine and the outcomes of nor-clozapine plasma levels (N-
interest statement.
CLZpl) has provided controversial results.
Aims.– To evaluate the association between weight gain and
E-PP0910 metabolic disregulation due to clozapine with levels of N-CLZpl.
Methods.– A retrospective chart review was undertaken to evaluate
The impact of long acting long-term security of patients in treatment with clozapine (CLOSE
paliperidone palmitate on clinical Project).
outcomes and hospital stay: a 6-year Clinical, anthropometric and analytical variables were measured at
mirror image study baseline, at18-weeks and 1-year.
S. Pappa1* , K. Mason2 Linear mixed models (LMMA) were used for statistical analysis.
1 West London MH NHS Trust, R&D, London, United Kingdom; 2 Results.– 222 eligible patients, 96 had enough data. The mean age
Birmingham and Solihull Mental Health Trust, Birmingham and was 32.72 (11.15) years. 63.1% were males and 43.6% were smok-
Solihull Mental Health Trust, Birmingham, United Kingdom ers. There was not any group*time effect in relation with gender,
* Corresponding author. age, clozapine oral dose and metabolic values in relation to the
evolution of N-CLZpl. A significant group*time effect was found
Background and aims.– There is a growing need for real world with diagnosis (P = 0.011), tobacco (P = 0.028), weight (P = 0.008),
data on clinical and health resource utilisation outcomes. The main BMI (P = 0.002), and HOMA classification (P = 0.06). LMMA analysis
purpose of this study was to establish the long term effects of 1- with BMI groups (NW, OWO), only tobacco presented a group*time
effect on N-CLZpl in both groups (P = 0.010 and 0.022, respectively).
Conclusions.– Weight changes might compromise clozapine clear- Background and aims.– Some classes of antidepressant drugs (SNRI,
ance in our sample. Predictors of N-CLZpl evolution might be NRI, MAOI, SSRI, TCA) may deteriorate sleep quality mainly due
different in those NW (diagnostic) in comparison with OWO to activation of serotonergic 5-HT2 receptors and increased nora-
patients (weight and HOMA index). Tobacco remains a predictor drenergic and dopaminergic neurotransmission. On the contrary,
of N-CLZpl evolution. Non-affective psychosis might predict higher antidepressants with antihistaminergic action, like sedating TCA,
N-CLZpl only in NW patients. Insulin resistance might also play a mirtazapine, mianserine, or strong antagonistic action at seroto-
role in clozapine clearance, but only in OWO patients. Considering nergic 5-HT2 receptors, like trazodone and nefazodone quickly
BMI subgroups might be of help for clozapine monitoring. improve sleep1 .
Disclosure of interest.– The authors have not supplied a conflict of Methods.– A pubmed search is performed with the descriptors
interest statement. “nightmares” and “antidepressants”.
Results.– Pharmacological agents affecting the neurotransmitters
norepinephrine, serotonin and dopamine are clearly associated
E-PP0912 with patient reports of nightmares. A possible association exists
Neuroleptic malignant syndrome between reports of nightmares and agents affecting the neuro-
associated with the use of lai transmitters acetylcholine, GABA and histamine. Vivid dreams and
nightmares have been reported with antidepressants that increase
antipsychotics: how to avoid?
REM sleep, such as bupropion3, mirtazapine4,5,6, citalopram7,
M. Pozzolo1* , N. Haddad1 , S. Fidelis1 , M. Pedro2
1 paroxetine8 and fluoxetine9.
Faculdade de Medicina do ABC, Psychiatry, Santo Andre, Brazil; 2
Conclusions.– Currently there is a great ignorance of the
Centro Universitário FAG, Medicine, Cascavel, Brazil
* Corresponding author. mechanisms by which nightmares occur in patients taking antide-
pressants. Although this effect is frequently observed in clinical
Background and aims.– Neuroleptic malignant syndrome (NMS) is practice, there is little literature on this, almost all in the form of
an uncommon but severe adverse effect on antipsychotic treat- clinical cases. Therefore, more research on this would be interest-
ment, with the four main symptoms being hyperthermia, muscle ing.
stiffness, autonomic dysfunction and altered level of consciousness. Disclosure of interest.– The authors have not supplied a conflict of
Also, less frequently, rhabdomyolysis and leukocytosis. NMS is dif- interest statement.
ficult to diagnose and often relies on time-cause relationships and
careful assessment of antipsychotic load. While NMS and its risk
factors are poorly understood, it is certain that careful monitoring E-PP0914
when initiating or changing antipsychotic regimens can prevent or Clinical outcomes following switching
mitigate adverse effects. antipsychotic treatment due to
Methods.– The present study aims to report a case of a patient, market withdrawal: a retrospective
diagnosed by DMS-V, with schizoaffective disorder, who presented
naturalistic cohort study of
NMS after the use of paliperidone depot, an incidence not men-
tioned in the literature. pipotiazine palmitate
Results.– Rapid alteration and a particular escalation of antipsy- R. Sheldon1* , M. Pereira2 , R. Whale3,4
1 Sussex Partnership NHS Foundation Trust, Millview Hospital,
chotic dose has emerged as an important risk factor for
development of NMS, with most cases occurring shortly after ini- Brighton and Hove, United Kingdom; 2 University of Coimbra, Faculty
tial exposure. NMS is less likely to occur in patients who have been of Psychology and Educational Sciences, Coimbra, Portugal; 3 Sussex
stable on their dose of antipsychotic medication for a long time or Partnership NHS Foundation Trust, Early Intervention in Psychosis
who have a long-term compliance. Antipsychotic polypharmacy, Team, Brighton and Hove, United Kingdom; 4 Brighton and Sussex
concomitant use of medications which predisposes to NMS and the Medical School, Department of Medical Education, Brighton, United
use of intramuscular medication all increase the risk of NMS. Rate Kingdom
of dose escalation of antipsychotic medication has been recognized
as a risk fator for NMS. ®
Background and aims.– Pipotiazine palmitate depot (Piportil ) was
Conclusions.– Pointing that out, a few issues emerged: how can LAI
an antipsychotic withdrawn from the UK marketplace in 2015.
antipsychotics induce or exacerbate NMS symptoms? Are the side
Uniquely, patients required switching to alternative antipsychotics,
effects worse than those observed in regular oral administration
not due to efficacy or side-effects. There are no large studies exam-
antipsychotics and is there any way to prevent NMS occurrence
ining such a cohort.
ensuring safety of its use.
We aimed to examine clinical outcomes of these patients 12 months
after switching from pipotiazine, including factors influencing dis-
interest statement.
continuation of the next medication prescribed and utilisation of
acute mental health services (AMHS).
E-PP0913 Methods.– A naturalistic retrospective cohort study, conducted
in one publicly-funded mental health trust in the South-East of
Nightmares and antidepressants: a England, UK, identified patients by patient record database search-
review ing. Age, gender, illness duration, pipotiazine duration, diagnosis,
M. Robles Martínez1* , R.F. Palma-Álvarez2 , M.Á. García-Carretero3 , four-weekly pipotiazine dose, concurrent antipsychotic use, switch
S. Aguelo Rueda4 , C. Rodríguez González4 , F. Fonseca4 , M. Torrens4 setting, and class of antipsychotic switched to were analysed. Mul-
1 Institute of Neuropsychiatry and Addictions INAD. Parc de Salut
tivariate logistic regression analysis and survival analyses were
Mar Barcelona- Spain., INAD, Barcelona, Spain; 2 3Addiction and performed to explore associations.
Dual Diagnosis Unit. Vall Hebron University Hospital. CIBERSAM. Results.– 100 eligible patients were identified, mean age 51, and 67
Barcelona- Spain, VHebron, Barcelona, Spain; 3 CTS-391 male. 83 had primary psychotic disorders. Mean pipotiazine dura-
Multidisciplinary Group for the progress of Mental Health- Cadiz tion was 5.4 years. 90 switched as outpatients. 67 remained on their
University. School of Nursing and Physiotherapy in Cadiz- Spain., new medication over 12 months. 57 switched to typical depots,
Cadiz, Cádiz, Spain; 4 INAD, INAD Barcelona, Barcelona, Spain 26 atypical depots, and 16 atypical orals. 28 used AMHS following
switch. No identified variables were statistically associated with
12 month discontinuation, however those discontinuing atypical
oral medications did so earlier. Only inpatient switch setting was voxamine therapy is often ineffective and some patients suffer from
associated with AMHS use within 12 months (P = 0.003). dose-dependent undesirable side effects. CYP2D6 is involved in
Conclusions.– Contrary to expectation, it made no difference which fluvoxamine biotransformation. The aim of our study was to inves-
antipsychotic patients were switched to after pipotiazine, when tigate the effects of CYP2D6 genetic polymorphisms on the efficacy
considering discontinuation and AMHS use by 12 months. Only and safety of fluvoxaminer in order to develop the algorithms of
switch setting was associated with likelihood of AMHS use by 12 optimization of fluvoxamine therapy.
months. Methods.– The study included 45 male patients with depressive
Disclosure of interest.– The authors have not supplied a conflict of disorder and comorbid alcohol use disorder who underwent the
interest statement. inpatient treatment. For the therapy of depressive disorder patients
®
received fluvoxamine in tablets (Fevarin ) at a dose of 100 [50; 150]
mg per day from day 5 to day 21 of the inpatient treatment course.
E-PP0915 Results.– It was shown that the efficacy and safety profiles of
Metabolic disturbances in newer fluvoxamine correlate with CYP2D6 genetic polymorphism. The
antipsychotics in patients with reduced efficacy and worsened safety profile of fluvoxamine ther-
schizophrenia: amisulpride vs apy were revealed in patients carrying one A allele in 1846G > A
(rs3892097). It correlates with the reduced biotransformation and
olanzapine elimination rates of fluvoxamine and drug cumulation. This leads
S. Singh1* , S. Ranjan2
1 to an increased amount of medication reaching the receptor tar-
National Medical College, Psychiatry, Birgunj, Nepal; 2 Universal
gets of fluvoxamine. The acceleration of serotonin transport in CNS
College of Medical Sciences, Psychiatry, Bhairahawa, Nepal
* Corresponding author. neurons results in dose-dependent undesirable side effects and in
the reduced efficacy of the depressive disorder therapy.
Background and aims.– Antipsychotics are the cornerstone for the Conclusions.– The study conducted in 45 patients revealed that
treatment of schizophrenia. Among them, atypical antipsychotics CYP2D6 genetic polymorphism could worsen the efficacy and safety
are flourishing as the first choice drugs. Despite overcoming the profiles of fluvoxamine. This should be considered when prescrib-
extra-pyramidal side effects of older generation antipsychotics, ing this medication to reduce the risk of undesirable side effects
the use of newer generation drugs, without doubt have a poorer and pharmacoresistance.
metabolic profile. Disclosure of interest.– The authors have not supplied a conflict of
Aims.– The aim of the study was to compare amisulpride and olan- interest statement.
zapine in terms of metabolic profile in patients diagnosed with
schizophrenia.
Methods.– A prospective, randomized, single-centre, 8 week long E-PP0917
clinical trial was used, with follow up at 4th and 8th week. Sixty Association of the pharmacokinetic
four adult patients were treated with standard doses of either genetic polymorphisms and
amisulpride (200 to 1200 mg/day) or olanzapine (5 to 20 mg/day). steady-state plasma concentrations of
Metabolic parameters such as weight, blood glucose, body mass
risperidone in autism spectrum
index were assessed in each follow up.
Results.– Greater weight gain was observed in the olanzapine group disorders
(7.66 ± 3.55 kg, p < 0.0001) as compared to the amisulpride group C. Sukasem
(2.25 ± 4.02 kg, p = 0.0035). No significant inter group difference Division of Pharmacogenomics and Personalized Medicine,
was found in terms of weight gain (p = 0.1019) among the two Department of Pathology- Faculty of Medicine Ramathibodi Hospital-
antipsychotics. Significant increase in random blood sugar was Mahidol University, Bangkok, Thailand
observed for patients in the olanzapine group (9.30 ± 15.30 mg/dL, Background and aims.– Our previous study investigated the genetic
p = 0.0007) but not in the amisulpride group (−2.03 ± 15.08 mg/dL, variants in drug metabolizing enzyme and transporter genes asso-
p = 0.2296). Mean change in Body Mass Index in the amisulpride ciated with steady-state plasma concentrations of risperidone
group was 0.85 ± 1.54 kg/m2 (p = 0.0022) and in the olanzapine among Thai ASD patients using DMET array.
group was 3.07 ± 1.57 kg/m2 (p = 0.0000). Significant difference in Objective.– The aim of the current study was to investigate the
BMI was found between the two groups (p = 0.0064) at the 8th association between variants of the pharmacokinetic genetic poly-
week. morphisms (CYP2D6, ABCB1, ABCB11, SLCO1B3, and UGT1A1) and
Conclusions.– Olanzapine caused greater changes in Body Mass steady-state plasma concentrations of risperidone and its metabo-
Index whereas Amisulpride offered a significant advantage in pre- lite 9-OH risperidone.
serving body weight and blood sugar. Methods.– Eighty-nine children and adolescents with ASD who
Disclosure of interest.– The authors have not supplied a conflict of were treated with a risperidone-based regimen at the same dose
interest statement. for at least 4 weeks prior to blood sample collection were included.
CYP2D6, ABCB1, ABCB11, SLCO1B3, and UGT1A1 were genotyped.
Plasma risperidone and 9-OH risperidone concentrations were
E-PP0916 measured.
Results.– In patients with CYP2D6 IM phenotypes, the plasma
Effects of CYP2D6 genetic
levels of risperidone (0.83 vs 0.25 ng/ml, P < 0.001), risperidone
polymorphisms on the efficacy and concentration/dose ratio (1.33 vs 0.23 ng/ml mg, P < 0.001) and
safety of fluvoxamine in patients with risperidone/9-OH risperidone ratio (0.20 vs 0.03, P < 0.001) were
depressive disorder and comorbid significantly higher than in patients with EM phenotypes. No
alcohol use disorder effect of CYP2D6 genetic polymorphisms on 9-OH risperidone and
V. Skriabin1 , M.S. Zastrozhin1 total activity was found. ABCB11 c.3084A > G variant and SLCO1B3
1 Moscow Research and Practical Centre on Addictions of the Moscow c.334G > T variant showed significantly higher risperidone C/D than
Department of Healthcare, Department No.16, Moscow, Russia wild-type, and UGT1A1*80 significantly affected the plasma levels
* Corresponding author. of 9-OH risperidone, and total active moiety. Meanwhile, ABCB1
c.3435C > T did not associate with plasma concentrations of risperi-
Background and aims.– Alcohol addiction is often comorbid with done and its metabolite.
affective disorders, worsening the prognosis of both diseases. Flu-
Conclusions.– CYP2D6 IM phenotype, ABCB11 c.3084A > G, and maximum dose of quetiapine in long term use should not exceed
SLCO1B3 c.334G > T variant will be the most suitable to predict 400 mg toward patients of northwest in China.
dose-corrected concentrations of risperidone. Conclusions.– Patients’ pharmacokinetics gene polymorphism is the
Disclosure of interest.– The authors have not supplied a conflict of important factor that affect quetiapine clinical response. 400 mg is
interest statement. best highest dose for patients of northwest in China.
interest statement.
E-PP0918
Tic due to sertraline use
S. Tunc1* , E. Buyuksandalyaci2 , H.S. Basbug3
1 Kafkas University, Department of Psychiatry, Kars, Turkey; 2 E-Poster Presentation: Psychophysiology
Bakirkoy Training and Research Hospital for Psychiatry- Neurology
and Neurosurgery, Department of Psychiatry, Istanbul, Turkey; 3
Kafkas University, Department of Cardiovascular Surgery, Kars, E-PP0920
Turkey Emotional context’s influence on
perceiving targeted facial expressions
Background and aims.– The frequent use of selective serotonin M. Chernykh* , T. Martynenko, I. Zyma
uptake inhibitors (SSRIs) has demonstrated an increasing number Taras Shevchenko National University of Kyiv, Educational and
of patients with movement disorders provoked by this group of Scientific Center “Institute of Biology”, Kyiv, Ukraine
drugs. Movement disorders most often related with SSRIs consist
akathisia, dystonia, parkinsonism, and tardive dyskinesia. There are Background and aims.– Human faces are complex multi-
rare reports of extrapyramidal adverse effects caused by sertra- dimensional stimuli, which provide a wide range of characteristics
line, being the most widespread akathisia. Tics are abrupt, short, for the brain to process. However, influence of the emotional
and episodic movements (motor tics) or sounds (phonic tics). Tics context on recognition and evaluation of facial expressions is not
can rise with stress and relaxation and decrease with distraction yet sufficiently investigated.
and concentration. In this paper, a 28-year-old female patient who The aim of this research was to study the effect of positive and
developed tics after being treated with sertraline was reported. negative faces on perception of targeted neutral facial expressions.
Methods.– A 28-year-old female admitted with the complaints of Current study is mainly focused on modulation of the event-related
depressed mood and markedly decreased pleasure in all activities potentials’ (ERP) components (N200, LPP, LPN).
most of the day, insomnia and loss of energy nearly every day for Methods.– 30 students of Taras Shevchenko National University of
three weeks. Kyiv (16 females, aged 18–24, mean = 21) were presented with two
Results.– Sertraline 25 mg/day was initially prescribed. Tics started series of images, during which visual ERPs were recorded. All stim-
after ten days beginning this medication. The sertraline was thus uli were selected from the International Affective Pictures System
stopped. After the drug cessation, tics was gradually subsided in (IAPS). Rare stimuli were shown in an arbitrary pattern in which
five days. likelihood of a rare stimulus (n = 100) appearance was 30%.
Conclusions.– As a conclusion, we wish to discuss the association Results.– N200 peak’s subcomponent (N2b), linked to discrimi-
between how increased serotonergic transmission by SSRIs and nation difficulties, was observed to be larger in right and left
movement disorders. Therefore, the clinicians should be aware of fronto-central cortical regions for neutral stimuli in positive con-
the likely occurrence of this side effect despite the low incidence of text. Increasing of LPPs’ amplitudes in temporal and left frontal
tic due to sertraline use. areas may stand for enhanced top-down mechanisms of emotion
Disclosure of interest.– The authors have not supplied a conflict of processing. Amplitude of LPN was overall larger for targeted neu-
interest statement. tral stimuli in positive context (significantly different in frontal and
temporal areas) and may indicate difficulties in stimuli retrieving.
Conclusions.– Valence of the stimuli creating emotional context
E-PP0919
for the targeted facial expressions affects perception, which is
Effect of pharmacokinetics gene expressed in increase of the level of attention and memory pro-
polymorphism on quetiapine cesses. Comparative analysis revealed more intense influence
Y. Zhang caused by negative emotional stimuli (ERPs’ components differed
Xi’an Mental Health Center, Pharmacy Lab, Xi’an, China in both middle and late latencies).
Background and aims.– Pharmacokinetics gene polymorphism is Disclosure of interest.– The authors have not supplied a conflict of
the important factor that affect antischizophrenia drug clinical interest statement.
response, study individual gene polymorphism and the connection
with the efficacy of quetiapine, to select individualized medication
for treatment and prevent the occurrence of adverse reactions to E-PP0921
provide reference to quetiapine in clinic, promote the development Constructive and non-constructive
of antischizophrenia drug individualized medication. coping strategies and
Methods.– 245 patients who of collected 844 patients treated with
quetiapine in Xi ‘an mental health center were retrospectively
psychophysiological properties of
analyzed, who had detected blood drug concentration and gene elite athletes
analysis. Analysis the relationship between the blood quetiapine S. Fedorchuk* , E. Lysenko, O. Shynkaruk
concentration with CYP2D6 and CYP3A5 gene polymorphism, also National University of Ukraine on Physical Education and Sport,
evaluation quetiapine efficacy in different pharmacokinetics gene Research Institute, Kyiv, Ukraine
polymorphism.
Results.– The therapeutic efficiency in quetiapine of patients in
Background and aims.– Studies of coping behavior in sports activ-
CYP2D6 poor metabolic type (PM) was better than that of exten-
ities are relevant because higher achievements require high
sive metabolic type (EM), while that the therapeutic efficiency in
psychological competence in the aspect of overcoming stress. Pur-
quetiapine of CYP3A5 gene EM was higher than that of PM. The
pose: to assess the influence of neurodynamic properties on the E-PP0923

formation of coping strategies with stress of elite athletes. Cardiovascular reactivity to stress in
Methods.– To determine the psycho-physiological properties of the
patients with coronary artery disease:
athletes’ nervous system, the diagnostic complex “Diagnost-1” was
used. To determine the strategies of stress-overcoming athletes’ the role of sleep quality
behavior, “WCQ, Ways of Coping Questionnaire” by R. Lazarus and J. Gecaite* , J. Burkauskas, J. Brozaitiene, N. Mickuviene
S. Folkman were used. In the study, the final indicator of the com- Laboratory of Behavioral Medicine- Neuroscience Institute,
petitive Trait Anxiety test was used. Lithuanian University of Health Sciences, Palanga, Lithuania
Results.– The correlation analysis revealed the presence of interrela-
tions between the index on the scale “Search for social support” and Background and aims.–
indicators of brain capacity for long sensorimotor loads, strength Introduction.– Associations between sleep quality and physiological
of nervous processes, dynamics of nervous processes in feedback stress reactions are still under-explored in coronary artery disease
mode and the rate of the complex reaction of choice. By the same (CAD) population.
criterion, the direct correlation was established between the indi- Objective.– To examine the extent to which subjective sleep quality
cator on the scale “Escape-avoidance” and the indicator of the is linked with cardiovascular reactivity to Trier Social Stress Test
dynamics of nervous processes in the feedback regime. The score (TSST) in patients with CAD.
on the “Taking responsibility” scale was associated with the speed Methods.– In total, 161 CAD patients (84% males, mean age: 53 ± 9)
of the sensorimotor response when two signals were selected from two weeks after acute coronary syndrome were evaluated for socio-
three. demographic and clinical CAD risk factors. TSST was performed to
Conclusions.– Specific psycho-physiological markers of such coping measure cardiovascular reactivity to social stress (systolic [sBP],
strategies as “Search for social support”, “Taking responsibility” and diastolic [dBP] blood pressure, and heart rate). Further, patients
“Escape-avoidance” can be considered the indicators of the strength were evaluated for subjective sleep quality (PSQI), depressive
and dynamics of nervous processes, the speed of complex reaction symptoms (BDI-II), and Type D Personality (DS-14).
of choice. Preference for non-constructive coping strategies for ath- Results.– After controlling for possible confounders, significant in
letes was associated with a decrease in the speed of the feedback univariate models (gender, age, NYHA functional class, arterial
operation. hypertension, depressive symptoms, Type D personality), multiple
Disclosure of interest.– The authors have not supplied a conflict of linear regression analysis indicated associations between poorer
interest statement. sleep quality and higher sBP and dBP during TSST period of Prepara-
tion time (sBP: ␤ = .183, p = .02; dBP: ␤ = .177, p = .03), and higher sBP
during Recovery time (␤ = .173, p = .03). Sleep disturbances were
E-PP0922
associated with higher sBP during the periods of Task preparation
Indices of stress level and nerve (␤ = .178, p = .04), Job interview (␤ = .200, p = .04), Arithmetic task
conduction in qualified athletes (␤ = .243, p = .03), and Recovery time (␤ = .195, p = .02). The overall
O. Kolosova, T. Khalyavka, S. Fedorchuk* , O. Lysenko PSQI score was associated with sBP during Baseline rest (␤ = .213,
National University of Physical Education and Sports of Ukraine, p = .01) and Recovery period (␤ = .178, p = .04).
Laboratory on Theory and Methodic of Sport Preparation and Reserve Conclusions.– Subjective sleep quality was linked with higher blood
Capabilities of Athletes, Kiev, Ukraine pressure during mental stress independently from possible con-
founders. Future studies may further explore associations between
objective sleep indices, neuroendocrinological and cardiovascular
Background and aims.– Psychoemotional tension and stress as an reactions to social stress in CAD patients.
integral part of the everyday life of the qualified athlete personality Disclosure of interest.– The authors have not supplied a conflict of
requires appropriate psychological readiness for successful sports interest statement.
activity. This phenomenon is in turn the subject of relevant inter-
disciplinary research in the context of preventing the development
of emotional burnout, keeping and improving the performance of E-PP0924
competitive activity, physical and mental health.
Features of the
Methods.– Stimulation electromyography (EMG) was performed on
the neurodiagnostic complex “Nicolet Viking Select”. The values of hypothalamic-pituitary-adrenal axis
nerve conduction velocities (NCV) for tibial and median nerves of response to acute stress in individuals
the upper and lower limbs at the right and left sides of the body with depression-like and anxiety-like
were obtained. To assess the effectiveness of mental self-regulation behavior: biomarkers of stress
and adaptability, the level of existing stress and emotional stability
vulnerability
the Luscher color test was used.
N. Goncharova
Results.– The relationship among electromyographic and psycho-
Research Institute of Medical Primatology, Experimental
logical indices in athletes performing in tennis was found. Higher
Endocrinology, Sochi, Russia
motor nerve conduction velocity corresponded to a lower level of
Background and aims.– Expansion of the stress factors range leads
stress, a higher level of effectiveness of mental self-regulation and
to an increase in the psychogenic load on the human being and
adaptability, a higher level of emotional stability. Thus, it can be
increased incidence of mental and psychosomatic diseases, espe-
assumed that the effectiveness of mental self-regulation and adapt-
cially in old age. However, the vulnerability to stress is individual.
ability, the level of existing stress and emotional stability can serve
The purpose of this study was to investigate individual and age-
as specific psychological indicators of changes in the functional
related features of the hypothalamic-pituitary-adrenal axis (HPA)
state of the neuromuscular system of young tennis players.
response to acute psycho-emotional stress and develop biomarkers
Conclusions.– Obtained results can be used to correct the training
of increased vulnerability to stress in the experiment on nonhuman
process of athletes.
primates.
Methods.– Young mature and old female rhesus monkeys with
interest statement.
depression-like and anxiety-like behavior (DAB) and control stan-
dard adaptive behavior (SB) were subjected to 2-hour moderate
restraint (ASE), tests with administration of corticotrophin releas-
ing hormone (CRH), arginine vasopressin (AVP), mineralcorticoid Taras Shevchenko University of Kyiv, Department of Social
and glucocorticoid receptor agonists (relatively fludrocortisone and Communication, Kiev, Ukraine; 3 Università della Svizzera italiana,
dexamethasone). Institute of Communication and Health, Lugano, Switzerland
Results.– The young monkeys with DAB demonstrated relative * Corresponding author.
resistance of HPA to suppression of dexamethasone and higher

increase of plasma corticotrophin in response to administration of Background and aims.– In present study we analyses the impact of
CRH and AVP in comparison with SB monkeys. At the same time, exposure to negative TV news, examining psychological effects of
old animals with DAB compared with old animals with SB showed negative TV news stories based on the viewers’ ability to perceive
the relative resistance of HPA to fludrocortisone, higher response of new information. The consequences of mass media impact or media
corticotrophin to ASE and tests with CRH and AVP and also higher effects represent a complex subject for research due to desensiti-
values of the cortisol/dehydroepiandrosterone sulfate molar ratio sation to the negative news. The level of Syndrome of Emotional
in plasma and the malondialdehyde in erythrocytes. Burnout is one of the basic indicators of personal ability to compre-
Conclusions.– Monkeys with DAB are more vulnerable to the hend new information, especially the information spread by mass
adverse effects of ASE. DAB behavior along with increased secre- media. The goal of the study is to reveal whether and how TV news
tion of corticotrophin in response to CRH and AVP administration stories alter psycho-emotional state of the audience depending on
and resistance of HPA to mineralcorticoid negative feedback can be the emotional burnout formation.
used to identify old individuals with increased vulnerability to ASE. Methods.– We used the Syndrome of Emotional Burnout Inventory
Disclosure of interest.– The authors have not supplied a conflict of by Boyko and a number of other inventories, aimed to analyze
interest statement. changes in viewers’ mood, state anxiety, internal aggression and
aggressiveness in the relationships. Overall 47 healthy volunteers
(19 male and 28 female students), aged 18 to 23 years old, partici-
E-PP0925 pated in the study.
Distinguishing quantitative Results.– The most significant impact of negative TV news was
found in the group of participants suffering from a large information
electroencephalogram findings overload and losing emotional sensitivity. Among the participants
between panic disorder and without any symptoms of burnout or those with fully formed
generalized anxiety disorder burnout, we recorded a less significant negative impact of negative
H.S. Suh* , K.S. Lee, Y. Cho TV news stories. We found a decrease the contempt and surprise
CHA University School of Medicine- CHA Gangnam Medical Center, facial reactions under burnout development.
Department of Psychiatry, Seoul, Republic of Korea Conclusions.– As such, emotional burnout in the stage of develop-
ment leads to personal discomfort and aggravation of perceptional
reactions in response to negative TV news.
Background and aims.– Generalized anxiety disorder (GAD) and Disclosure of interest.– The authors have not supplied a conflict of
panic disorder (PD) are common diagnoses in anxiety disorders. interest statement.
However, it is difficult to distinguish GAD from PD. Neurobehavioral
markers that differentiate GAD and PD would be helpful in ongo-
ing efforts to refine classification schemes based on neurobiological E-PP0927
measures. The aim of this study was to determine the distinguish-
Patterns of activation of the
ing neurophysiological characteristics between GAD and PD using
quantitative analysis of an electroencephalogram (QEEG). autonomous nervous system under
Methods.– The study included 36 patients with GAD and 25 patients watching to the emotionally accented
with PD. Resting (eye closed) vigilance controlled EEG recordings tv news
were assessed at 64 electrode sites according to the international S. Tukaiev1* , Y. Havrylets1 , V. Rizun1 , I. Zyma2 , M. Makarchuk3 , I.
10/20 system. QEEG were compared between GAD and PD groups Seleznov4
by frequency bands (delta 1–3 Hz, theta 4–7 Hz, alpha 8–12 Hz, beta 1 National Taras Shevchenko University of Kyiv, Department of Social
12–25 Hz, high beta 25–30 Hz, gamma 30–40 Hz and total 1–40 Hz) Communication- Institute of Journalism, Kiev, Ukraine; 2 National
made by spectral analysis. Taras Shevchenko University of Kyiv, Department of Physiology of
Results.– The absolute powers of theta and alpha bands at the frontal Brain and Psychophysiology, Kiev, Ukraine; 3 National Taras
area differed between GAD and PD group. The absolute power of Shevchenko University of Kyiv, The Institute of Biology and Medicine,
the theta activity was decreased in FP1 and FP2 (p < 0.05) and the Kiev, Ukraine; 4 National Technical University of Ukraine “Igor
absolute power of the alpha activity was decreased in F3 (p < 0.05) Sikorsky Kyiv Polytechnic Institute”, Department of electrical
in cases with GAD compared to PD. engineering, Kiev, Ukraine
Conclusions.– The differences in QEEG power in our investiga- * Corresponding author.
tion suggest that underlying pathophysiologic mechanisms may

be different between GAD and PD. The findings that the decreased Background and aims.– The pattern and nature of autonomic ner-
absolute powers of the theta and alpha activity at the frontal area vous system responses largely depend on the type of emotion. The
in GAD may be the main neurophysiological characteristics of the study is aimed to define the shifts in the autonomic nervous system
GAD. that accompanied the emotional activation under the influence of
Disclosure of interest.– The authors have not supplied a conflict of emotionally accented TV-news.
interest statement. Methods.– 53 healthy right-handed volunteers (33 women and 20
men) participated in this study. The recorded ECG data array was
processed using algorithms for heart rate variability. We used two
E-PP0926 sets of videos, five items in each set, with emotionally negative and
Impact of tv news’ violence on the neutral news stories.
Results.– We observed a heart rate deceleration in a few minutes
psycho-physiological state depending after the watching the neutral video set. At the same time through-
on emotional burnout out the viewing of the video the activity of the parasympathetic
S. Tukaiev1* , Y. Havrylets2 , V. Rizun2 , I. Zyma1 , O. Radchuk3 system and the stress index have decreased. Negative accented TV
1 National Taras Shevchenko University of Kyiv, Department of news caused more complex changes. In men, significant changes in
Physiology of Brain and Psychophysiology, Kiev, Ukraine; 2 National heart rate were recorded only during the first TV news. The most
significant changes in the influence of the parasympathetic system consists of antipsychotic medications combined with psychological
and the stress index occurred in the middle of negative TV news interventions. Almost for one third of patients with schizophrenia,
set. The influence of negative TV news stories was more significant AVH do either not or not sufficiently yield to these interventions.
and complex for women and consisted in a decrease in heart rate Therefore, alternative modalities for treating refractory AVH are
during watching of TV news stories and a heart rate accelerations needed. Among these approaches, repetitive magnetic stimulation
in the pause between them. A significant decrease in the activity of (rTMS), which is a non-invasive neuromodulation technique, has
the parasympathetic system occurred after the watching negative currently evolved.
TV news sets. Methods.– We report retrospectively the case of a patient suffer-
Conclusions.– Regarding all the parameters negative TV news sto- ing from schizophrenia with resistant Auditory Hallucinations and
ries exert a more significant influence on the psycho-physiological treated by rTMS.
condition of the volunteers. Results.– A 35-year-old woman was referred by her psychiatrist to
Disclosure of interest.– The authors have not supplied a conflict of the psychiatric department “B” of Razi Hospital. She has been suf-
interest statement. fering from schizophrenia since she was 29. She was treated with
first generation antipsychotic (fluphenazine), then with atypical
antipsychotics (risperidone). Nevertheless, response was incom-
E-PP0928 plete and AVH persist. Prior to rTMS, CGI was 4, PANSS 70 and
Observer-rated retardation but not PSYRATS 31. She had benefited, in association with medical treat-
agitation corresponds to objective ment, from 10 daily sessions of low frequency rTMS (1HZ, 1200
motor measures in depression pulses and 100% of motor threshold) over the left temporoparietal
L. Van Diermen1* , S. Walther2 , O. Cools1 , E. Fransen3 , T. cortex placed in a half way between T3 and P3, using the EEG inter-
Birkenhäger1 , B. Sabbe1 , D. Schrijvers1 national system. After ten days of stimulation there was a clinical
1 UAntwerpen, Faculty of Medicine and Health Sciences, Antwerp, improvement in frequency and duration of AVH. Her PANSS became
Belgium; 2 University Hospital of Psychiatry- University of Bern, 36 and PSYRATS 24.
Translational Research Center, Bern, Switzerland; 3 UAntwerpen, Conclusions.– Our results show the potential benefit of rTMS in
StatUA center for statistics, Antwerp, Belgium resistant Auditory Hallucinations among patients suffering from
* Corresponding author. schizophrenia. Further studies are, however, needed in larger num-
ber of patients, to assess long-term effects of this technique.
Background and aims.– To explore the correlations between Disclosure of interest.– The authors have not supplied a conflict of
observer ratings and instrumental parametersacross domains of interest statement.
psychomotor functioning in depression.
Methods.– In total, 73 patients withmajor depressive disorder
underwent extensive psychomotor and clinical testing. Psychomo- E-PP0930
torfunctioning was assessed with (i) an observer-rated scale (the Long-term effects of electroconvulsive
CORE measure) and alsoobjectively with (ii) 24-h actigraphy, and therapy: the case of two patients
(iii) a fine motor drawing task. undergoing more than 10 years of
Results.– Observer ratingsof retardation correlated with instrumen-
tal assessments of fine and gross motor functioning. Incontrast,
treatment
F. Caetano* , S. Carvalho, C. Silva
observer ratings of agitation did not correlate with observer ratings
Hospital de Magalhães Lemos, Psychiatry, Porto, Portugal
of retardation orwith the instrumental measures. These associ- * Corresponding author.
ations were partly influenced by age and, to a lesserextent, by
depression severity. Background and aims.– Electroconvulsive therapy (ECT) was one
Conclusions.– Psychomotor disturbance is a complex concept with- of the first effective treatments to psychosis. Despite its results
different manifestations in depressed patients. Although observer on acute psychopathology, the scientific community worried
ratings of retardationcorrespond well with instrumental measures about long-term effects on cognitive function. Using two cases
of the motor domains, objective measurement ofagitation and we illustrate how long-term ECT can be successful against
other aspects of psychomotor disturbance require further research. treatment-resistant severe mental illness without significant cog-
Disclosure of interest.– The authors have not supplied a conflict of nitive deterioration.
interest statement. Methods.– Review of the clinical history and related literature.
Results.– We present the case of two unrelated patients (MS and FS)
treated with ECT almost uninterruptedly over the course of more
than 10 years (14 and 11 years, respectively). MS, female, born in
E-Poster Presentation: Psychosurgery &
1967 (presently 51 years old), with a diagnosis of Schizoaffective
Stimulation Methods (ECT, TMS, VNS, DBS) - Part I / disorder, started treatment in 2004 for a manic episode with psy-
Women, Gender and Mental Health - Part I chotic features. FS, female, born in 1939 (presently 78 years-old),
with a diagnosis of persistent depressive disorder, started treat-
ment in 2007 for psychotic depression with severe anorexia. Both
E-PP0929 begun treatment with 12 acute ECTs. Due to clinical improvement,
Repetitive transcranial magnetic both patients proceeded to a monthly maintenance treatment. In
these two cases we unsuccessfully tried to reduce frequency or dis-
stimulation in the management of
continue ECTs. In 2018 both patients are stable under maintenance
auditory hallucinations in patients monthly treatment, without evidence of cognitive deterioration.
with schizophrenia: a case report Conclusions.– Regarding short-term effects, most patients report
R. Ben Massoued* , O. Moula, E. Sahar, G. Malek, G. Rim some sort of adverse cognitive consequences during and after ECT.
Razi hospital- Mannouba, Psychiatric Department B, Mannouba, Despite that, the long-term effects of ECT on memory is still contro-
Tunisia versial: some authors report long term memory impairment, while
others say that the effect of correctly performed ECT on memory
is comparable to other treatments. We contribute to this discus-
Background and aims.– Auditory verbal hallucinations (AVH) rep-
sion by presenting two cases without clear evidence of cognitive
resent a prominent symptom in schizophrenia. Treatment usually
deterioration.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– 67-year-old woman was acutely received on psychiatric
interest statement. ward. She has been received there because her schizoaffective dis-
order got worse. That was shown in the form of increasing tension,
hyperventilation, trembling, rigidity, anxiety and impaired think-
E-PP0931 ing. In treatment of medicine resistance, ECT was applied as wall
Repetitive transcranial magnetic known method of choice.
stimulation augmentation in Results.– Since 2009, in the patient’s case, the following psy-
chotropic drugs have been used in sufficient dosage and in sufficient
clozapine-resistant schizophrenia: a
time: benperidol, melperone, risperidone, paliperidone, olanza-
Tunisian sample pine, clozapine, amisulpride, ziprasidone, mirtazapine, doxepin,
M. Gharmoul* , J. Nakhli, A. Braham, S. Ben nasr benzodiazepines. However, they didn’t give satisfactory results in
Farhat Hached University Hospital, Psychiatry Department, Sousse, treatment of schizoaffective disorder. As a final treatment, ECT was
Tunisia used.
Conclusions.– 67 old patient with schizoaffective disorder has been
Background and aims.– Several studies have shown that left received to psychiatric ward. Due to lack of response to pharma-
temporoparietal repetitive transcranial magnetic stimulation cotherapy treatment, electroconvulsive therapy was used. There
decrease verbal hallucinations in Clozapine-resistant schizophre- were carried out, as required, a total of 8 treatments EKT- through
nia patients. bilateral stimulation starting with 20% to 80% of max. Stimulation
The objective of this study is to examine the benefit of low energy over 3 weeks. Accompanying med. therapy with sertraline
frequency left temporoparietal repetitive transcranial magnetic and aripiprazole.
stimulation (rTMS) in those patients. After the treatment there was a significant improvement in
Methods.– During the last 3 years, seven patients from a Tunisian patient’s mood and regression of delusional symptoms.
psychiatric hospital in whom rTMS was used to augment treat- Disclosure of interest.– The authors have not supplied a conflict of
ment with Clozapine were followed. All these patients had partial interest statement.
response to Clozapine. One Hz stimulation at 90% motor threshold
was then given midway between the left temporal (T3) and left
E-PP0933
parietal (P3) electroencephalogram electrode sites. Patients were
evaluated clinically and symptomatically on their auditory halluci- Serum brain derived neurotrophic
nations at baseline, after each week and at the end of rTMS sessions. factor as a potential biomarker for
Results.– The mean age was 30.7 years (SD = 7.3). Patients were male clinical improvement in patients of
in 57.1%. The total mean duration of illness was 9.5 years (SD = 4.5) schizophrenia undergoing
and the undifferentiated schizophrenia subtypes was the most
electroconvulsive therapy
prevalent (71.4%) The mean dose of Clozapine was 557 mg/day
A. Koolwal1* , G. Koolwal Das2 , S. Sudarsanan3 , S. Agarwal4
(SD = 164). The mean number of rTMS daily session was 15.7 1 JSS Medical College, Psychiatry, Mysore, India; 2 Dr. S. N. Medical
(SD = 5.6). We found that 4 patients of our sample have significant
College, Psychiatry, Jodhpur, India; 3 AIMST University, Faculty of
clinical improvement and they have a disappearance of anxiety and
Medicine, Bedong, Malaysia; 4 Subharti Medical College, Psychiatry,
auditory hallucinations. For the 3 other patients we noted a failure
Meerut, India
of rTMS to reduce verbal hallucinations and mental automatism. * Corresponding author.
Conclusions.– In this ultra-resistant group, we showed an average
response rate of 57%. Our observations also support the beneficial Background and aims.– Electroconvulsive Therapy (ECT) has a
effect of rTMS as an augmentation strategy for Clozapine-resistant history of long and efficacious use for a variety of psychiatric
schizophrenia patients. conditions like Schizophrenia, Bipolar Disorder and Major Depres-
Disclosure of interest.– The authors have not supplied a conflict of sive Disorder. But despite that the mechanism of action of ECT
interest statement. remains an enigma, with upregulation of neurotrophins, like Brain
Derived Neurotrophic Factors (BDNF), being a potential mechanism
of action. In this To explore the role of BDNF as a potential biomarker
E-PP0932 for clinical improvement, in patients of schizophrenia, undergoing
Electroconvulsive therapy (ECT) for ECT, by assessing the serum BDNF levels before and after the ECT.
treatment resistant schizoaffective Methods.– A total of 21 patients, diagnosed with Schizophrenia
disorder and prescribed ECT, were included. Clinical assessment, using Pos-
B. Janota1* , G. Roganovic1 , J. Schönwälder2 , K. Janota3 itive and Negative Symptoms Scale (PANSS), and serum BDNF level
1 Psychiatry, Department of Psychiatry- Psychotherapy and assessment, using BDNF ELISA test, were done before and after the
Psychosomatik, Cottbus, Germany; 2 Psychiatry, Department of prescribed course of ECT.
Psychiatry- Psychotherapy and Psychosomatik, Spremberg, Germany; Results.– The mean serum BDNF level, before ECT, was found to be
3 MVZ, Internal Medicin- Endocrinology and Diabetology, Cottbus, 1691.59 ng ± 145.23, which increased to, 1746.67 ng ± 184.31, after
Germany ECT. This increase, seen along with the clinical improvement, in
* Corresponding author. which the PANSS score decreased significantly (P < 0.001), was not
found to be statistically significant (P > 0.05). No correlation was
Background and aims.– Psychotherapy and pharmacotherapy have found between the clinical improvement and the increase in the
made great progress in the treatment of severe mental illness. At the BDNF levels.
same time it’s becoming that even with optimal application not all Conclusions.– The results do not support the use of serum BDNF
patients respond adequately to these therapies. Electroconvulsive levels as a biomarker for clinical improvement in the patients of
therapy (ECT) is especially used for depressive disorders, but also schizophrenia undergoing ECT. But since there was an increase, in
for schizophrenic psychoses as a complementary therapy method. the serum BDNF levels along with the clinical improvement, its role
A case report has shown a positive ECT influence of treatment as a potential biomarker for clinical improvement in schizophrenia
at patients with negative symptoms with medicine resistance should be explored further.
schizoaffective disorder. Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
E-PP0934 described the case and discuss the different clinical presentations
Family sensitive ECT of catatonia. The electroconvulsivotherapy was the last resort, fully
G. Kuruvilla* , A. Elias, A. Ang succeeded.
Eastern Health, Mental Health, Melbourne, Australia Conclusions.– The relationship between SMN and Catatonia/MC
* Corresponding author. remains nuclear from a psychopathological and pathophysiological
point of view. There is general agreement that catatonia repre-
Background and aims.– There is much stigma and misinformation sents a significant risk factor for NMS. A promptly diagnostic is
about ECT which has hampered the use of ECT. Family attendance crucial to provide adequate treatment and to avoid drugs that can
at ECT has not been systematically studied previously. worsen/perpetuate the clinical state.
Methods.– 69 consecutive patients were approached about their Disclosure of interest.– The authors have not supplied a conflict of
family members attending and observing ECT. The inclusion crite- interest statement.
ria for entry to the ECT suite were consent from both the patient
and family member, age over 18 years and one family member at
a session. After watching ECT family members completed a ques- E-PP0936
tionnaire about their experience. Application of transcranial magnetic
Results.– 21 family members attended and watched ECT being given stimulation (RTMS) for
to their relative. Majority viewed attendance at ECT as reassuring
and only a few indicated that it was anxiety provoking. Five (24%)
treatment-resistant depression in
felt some distress while watching while 16 (76%) rated their experi- schizophrenia
ence as comfortable or rewarding. A clear majority responded that N. Maslenikov* , E. Tsukarzi, S. Mosolov
watching the procedure alleviated their fears about ECT or pro- Moscow Research Institute of Psychiatry, Department for treatment
duced transformative knowledge (71%) while a minority felt no of mental disorders, Moscow, Russia
change in their attitude about ECT (29%). Most of the participants
recommended watching ECT to other family members (62%) while
Background and aims.– Depression is the most common co-
a minority was uncertain (38%). There were no adverse effects, pre-
occurring syndrome in schizophrenia, which deteriorates quality
mature exit from the ECT suite, interference with the treatment or
of life and outcome of disease. Insufficient clinical response to
any litigations.
adequate pharmacotherapy determines rising interest to brain
Conclusions.– There was a clear majority of families who viewed
stimulation techniques such as rTMS. The aims of this study were
their attendance at an ECT session as a beneficial experience. Family
to evaluate safety and efficacy of rTMS for treatment-resistant
presence during ECT has the potential to promulgate its practice by
depression in schizophrenia and to find out possible predictors of
reducing stigma and misconceptions, At our service we have incor-
response.
porated family presence as normal practice following the research
Methods.– 31 schizophrenia (ICD-10) patients with prominent neg-
project.
ative symptoms and depression (CDSS ≥ 6) on constant combined
pharmacotherapy (effective antipsychotic + ineffective antidepres-
interest statement.
sant of the 2nd line) in adequate dosing regimen and exposition (≥6
weeks) were included in the study. Patients received 15-Hz rTMS on
E-PP0935 the left dorsolateral prefrontal cortex (100% intensity, 15 sessions of
1800 pulses). Neuro-MS/D stimulator (“Neurosoft”, Russia) with 8-
Electroconvulsivotherapy as shaped coil was used. Patients were assessed with CDSS and PANSS
life-saving in an acute catatonic weekly. The criterion of efficacy was 50% CDSS score reduction after
syndrome associated with bipolar the 3rd week of treatment.
disorder: a case report Results.– The number of responders was 20 (64,5%), mean CDSS
R. Leite* , J. Borges, J. Alcafache, T. Santos, A. Rei, A. Mesquita score reduction was 55,2% (p = 0,000004), mean PANSS negative
Baixo Vouga Hospital Centre, Psychiatry and Mental Health subscale score reduction was 21,3% (p = 0,000012). Rapid onset
Department, Aveiro, Portugal of rTMS effect on depressive symptoms was detected: mean
* Corresponding author. CDSS score reduction after the 1st week of treatment was 39,0%
(p = 0,000004). Positive outcome of rTMS was associated with
Background and aims.– Catatonia is a neuropsychiatric syndrome marked motor retardation and residual psychotic symptoms at the
characterized by an onset of a dysfunction in psychomotor activ- baseline and feminine gender. Patients with severe negative symp-
ity and/or muscle tone, which may be associated with changes toms tended to poor response.
in consciousness, affect, and thinking. It was first described in Conclusions.– The study revealed that rTMS is safe and effective
1874 by Kahlbaum, who characterized it as specific motor disor- strategy for the management of treatment-resistant depression in
der associated with different psychiatric disorders. Kraepelin and schizophrenia. Further sham-controlled studies are needed.
Bleuler restricted catatonia to a specific subtype of schizophrenia. Disclosure of interest.– The authors have not supplied a conflict of
However, the association between catatonia and other disorders, interest statement.
notably mood disorders, has been reinstated, including Bipolar Dis-
order (BD). Its etiology is multiple and there are two severe forms:
Neuroleptic Malignant Syndrome (NMS) and Malignant Catatonia E-PP0937
(MC). These are syndromes that present high mortality. The aim Comparison of cognitive side effects
of this study is to recognize the different clinical presentations of between 0.5 milliseconds and
catatonia, taking into account that these are psychiatric alterations
in which urgent intervention is justified.
1 millisecond pulse width bilateral
Methods.– Case report, sustained by a literature review included in electroconvulsive therapy in major
scientific databases PubMed, and Cochrane Library. depression
Results.– In the presented case of an acute catatonic syndrome C. Massaneda1* , M. Laura Fernández1 , A. de Arriba Arnau2 , V.
associated with BD, the use of antipsychotic medication has wors- Soria3 , N. Salvat-Pujol2 , J.M. Menchón3 , M. Urretavizcaya3
1 Bellvitge University Hospital -Institut Català de la Salut ICS,
ened the motor function and its suspension, associated with the
introduction of lorazepam, resulted in a slight improvement. We Psychiatry Department, Hospitalet del Llobregat, Spain; 2 Bellvitge
University Hospital -Institut Català de la Salut ICS- Bellvitge Background and aims.– Gender differences have been described as
Biomedical Research Institute IDIBELL Neurosciences determinant predictors of treatment response of different psychi-
Group-Psychiatry and Mental Health- Mood Disorders Clinical and atric disorders. Lately there has been a growing interest in this
Research Unit- Bellvitge University Hospital, Psychiatry Department, field in order to clarify which gender differences could influence
Hospitalet del Llobregat, Spain; 3 Bellvitge University Hospital electroconvulsive therapy (ECT) treatment.
-Institut Català de la Salut ICS- Bellvitge Biomedical Research The aim of the study was to study the effect of gender in ECT treat-
Institute IDIBELL Neurosciences Group-Psychiatry and Mental ment.
Health- Mood Disorders Clinical and Research Unit- Bellvitge Methods.– The sample included 66 age and gender matched patients
University Hospital, University of Barcelona UB- Centro de with unipolar depression retrospectively collected from ECT unit
Investigación Biomédica en Red de Salud Mental-CIBERSAM G17, medical charts. The sample was divided into groups according
Psychiatry Department, Hospitalet del Llobregat, Spain to gender. Comparisons were done by Student’s T-test or Mann-
* Corresponding author. Whitney U-test using p < 0.05 (bilateral).
Results.– ECT response and remission rates were similar between
Background and aims.– Electroconvulsive therapy (ECT) is an groups, however statistically significant differences were found
effective treatment for severe and resistant depression. Notwith- in other variables: female patients had more previous episodes
standing that cognitive impairment remains a common side effect, (2.30 ± 1.591 vs 4.09 ± 3.055; U:359, p = 0.016), lower anesthetic
its minimization has led to the study of alternative technique dose (193.68 ± 52.278 vs 163.34 ± 43.652; t:2.535, p = 0.014), less
modifications while administering ECT. Ultra-brief pulse (≤0.3 ms) sessions needed (12.58 ± 3.021 vs 10.39 ± 3.010; t:2.939, p = 0.005),
seems to decrease cognitive side effects compared to brief-pulse and lower post-ECT MEC scores (32.30 ± 2.658 vs 27.20 ± 7.153;
ECT (0.5–1.5 ms). Could the use of 0.5 ms or 1ms pulse make any U:71, p = 0.008). MEC scores were not adjusted by education level.
difference in cognitive performance? To date there are no studies Conclusions.– There were differences in illness course and in ECT
addressing this topic. factors such as anesthesia dosage needed, speed of response and
The objective of the study was to compare the effect of 0.5 vs 1 ms cognitive tolerance depending on the gender. Further research is
pulse width (PW) in cognition after an acute treatment course with warranted to better understand the basis of gender difference and
ECT. its influence on the effect and tolerance of ECT, in order to individ-
Methods.– The sample included 30 unipolar depression patients ualize ECT treatment.
undergoing acute ECT (15 treated with 0.5 ms PW and 15 with 1 ms Disclosure of interest.– The authors have not supplied a conflict of
PW) that completed MMSE before ECT and after the last session. interest statement.
Both groups were comparable in age, illness severity and baseline
MMSE.
To compare test scores between PW groups, Student’s T-test (in E-PP0939
normal distribution variables) and Mann-Whitney U-test were Sex/gender differences in autism
used.
Results.– Different patterns of changes in MMSE scores between
spectrum disorder
J. Aguiar
0.5 ms group (from 24.40 (8.14) at baseline to 29.80 (4.69) post-ECT)
Centro Hospitalar Psiquiátrico de Lisboa, General Psychiatry, Lisboa,
and 1 ms group (26.93 (5.28) to 25.91 (6.61)) were observed. How-
Portugal
ever the differences between groups in MMSE scores after ECT and
Background and aims.– Autism spectrum disorder (ASD) is a
the change from baseline scores, were not statistically significant
neurodevelopmental condition that affects communication and
(5.40 (8.26) vs 0.50 (4.08); p = 0.097).
behavior. Clinical presentation typically includes difficulties with
Conclusions.– 0.5 ms PW resulted in higher scores and improvement
communication and social interaction, as well as restricted inter-
in cognitive tests compared to PW 1 ms post-ECT, although the
ests and repetitive behaviors, which may compromise functioning
difference was not statistically significant. The small sample size
at school, work and social life. Being a spectrum disorder, there is
might be insufficient to prove statistically significant results.
a wide variation in the type and severity of symptoms, sometimes
making the diagnosis challenging. There is increasing evidence that
interest statement.
there may be sex/gender differences in clinical presentation, since
some traits appear to be more specific of the female phenotype.
E-PP0938 The aim of this work was to understand the most common
sex/gender differences in ASD clinical presentation, and its impact
The role of gender in on diagnosis and treatment.
electroconvulsive therapy: a factor to Methods.– Review of the literature using the PubMed platform, with
consider in our daily practice the keywords “autism”, “gender” and “female”.
C. Massaneda1* , L. Martínez Fernández1 , A. de Arriba Arnau2 , N. Results.– According to the literature, females with ASD may present
Salvat-Pujol2 , V. Soria3 , J.M. Menchón3 , M. Urretavizcaya3 more frequently with compensatory behaviors in social context,
1 Bellvitge University Hospital -Institut Català de la Salut ICS,
stronger imaginative play, more interest in social relationships and
Psychiatry Department, Hospitalet del Llobregat, Spain; 2 Bellvitge more socially acceptable and less restricted interests, creating a
University Hospital -Institut Català de la Salut ICS- Bellvitge camouflage phenomenon that may mask their diagnosis. Females
Biomedical Research Institute IDIBELL Neurosciences without intellectual impairment and milder symptoms tend to be
Group-Psychiatry and Mental Health- Mood Disorders Clinical and diagnosed at later ages than males, some being misdiagnosed with
Research Unit- Bellvitge University Hospital, Psychiatry Department, anxiety or personality disorders.
Hospitalet del Llobregat, Spain; 3 Bellvitge University Hospital Conclusions.– An increasing number of authors highlight a male bias
-Institut Català de la Salut ICS- Bellvitge Biomedical Research in our current perception of ASD. Further research is needed to
Institute IDIBELL Neurosciences Group-Psychiatry and Mental achieve a better understanding on sex/gender differences on ASD,
Health- Mood Disorders Clinical and Research Unit- Bellvitge in order to ensure proper diagnosis and treatment to undiagnosed
University Hospital, University of Barcelona UB- Centro de females.
Investigación Biomédica en Red de Salud Mental-CIBERSAM G17, Disclosure of interest.– The authors have not supplied a conflict of
Psychiatry Department, Hospitalet del Llobregat, Spain interest statement.
E-PP0940 Background and aims.– The prevalence of postpartum depression

Substance use and mental health (PPD) in Taiwan was 10.3–73.3%. Previous studies show inconsis-
disorders on pregnancy: preliminary tent results in the relationship of cesarean section (CS) and PPD.
This study aimed to assess the relationship between the type of
results of prevalence and usual care delivery and PPD in the first-time mothers, and also to evaluate the
from the WOMAP study change of sense of parenting competence in Taiwanese women.
R. Carmona Camacho1* , N. Lopez Carpintero2 , M.L. Barrigón Methods.– The study recruited 81 healthy first-time-mothers from
Estevez1 , I. Caro Cañizares1 , J.J. Hernandez Aguado2 , M. Andeyro3 , the medical center in Taipei. According to the type of delivery,
J. Plaza4 , M. Alegria5 , B. Cook6 , J. Fernandez Aurrecoechea1 , E. Baca they were divided into the spontaneous delivery (SD) group (n = 40)
García1 and CS group (n = 41). Data of the 1st week, and 1st, 2nd, 3rd, 6th
1 Jimenez Diaz Foundation University Hospital, Psychiatry, Madrid,
month at postpartum were collected. The Chinese version of mea-
Spain; 2 Infanta Leonor Hospital, Obstetrics and Gynecology, Madrid, surements including Edinburgh Perinatal Depression Scale (EPDS)
Spain; 3 VIllalba General Hospital, Obstetrics and Gynecology, and Parenting Sense of Competence Scale (PSOC) were used in the
Madrid, Spain; 4 Jimenez Diaz Foundation University Hospital, study.
Obstetrics and Ginecology, Madrid, Spain; 5 Massachusetts General Results.– No difference in personal characteristics, breastfeeding
Hospital and Harvard Medical School-, Disparities Research Unit, and baby care practices was found between groups. The SD group
Boston, USA; 6 Cambridge Health Alliance and Harvard Medical spent more time to care for babies at the first week of postpar-
School, Health Equity Research Lab, Boston, USA tum and found no difference in that at the following visited time
(Fig-1A). The score of EPDS in the CS group (Fig-1B) was signifi-
cantly higher than that in the SD group, but no one was referred to
Background and aims.– Smoking and substance use during preg-
a psychiatrist in our study. Additionally, no difference in PSOC score
nancy is the main preventable cause of mortality and morbidity,
was found between the two groups (Fig-1C). A positive association
having a bidirectional and deleterious relationship with mental
was found between CS and EPDS (regression coefficient = 1.589,
health. In general, these problems are unserved.
p = 0.001).
With data obtained from the first months of the WOMAP (Woman
Mental Health and Addictions on Pregnancy) study we aimed to
describe 1) the prevalence of these problems using the AC-OK, 2)
the treatment ratio, and 3) diagnosis and severity of those who
fulfill inclusion criteria.
Methods.– 620 women under 26 weeks of pregnancy were screened
with the AC-OK and asked about smoking habit between July 2016-
September 2017.
Those screened as positive (66) were assessed with a more exten-
sive battery of measures (PHQ-9, GAD-7, PCL-5, AUDIT, DAST and
Fagerström) In addition, they were asked about mental health/drug
abuse services used. An observational descriptive study was made.
Results.– Analysis showed that 129 women (27.3%) smoked tobacco
in the last year (55.6% daily). 10.6% were positive for dual prob-
lems according to the AC-OK. From the subsample (66) evaluated in
depth, 28 (43.1%) were positive to at least moderate depression, 14
(21.2%) to at least moderate anxiety, 12 (20%) to PCL (PTSD) and 30
scored above the threshold in AUDIT-C (55.6%). The consumption
of other drugs was anecdotal. Only 6.1% of these women received
specific treatment in the previous three months and 15.2% were to
be attended in the following month.
Conclusions.– The combination of high prevalence, low treatment
ratio and major preventable consequences suggest that effective
detection mechanisms should be integrated into usual care, allow-
ing an adequate and early intervention and access to treatment.
interest statement.
E-PP0941
Figure 1. Trends of the mother care baby time, scores of postpartum
Cesarean section was associated with depression, and parenting competency in different delivery type.
postpartum depression in taiwanese T1: the 1st week – T2: the 1st month – T3: the 2nd month – T4: the
first-time-mothers 3rd month – T5: the 6th month after delivery.
F.F. Chung1,2* , G.H. Wan3,4,5 A) Care baby time per week – B) EPDS – C) PSOC.
1 Chang Gung University of Science and Technology, Department of *: p < 0.05.
Nursing, Taoyuan, Taiwan R.O.C.; 2 Linkuo Chang Gung Memorial
Conclusions.– The health care workers need pay more attention on
Hospital, Department of Nursing, Taoyuan, Taiwan R.O.C.; 3 Chang
the first-time-mothers with cesarean section during the postpar-
Gung University, Department of Respiratory Therapy, Taoyuan,
tum six months to ensure their mental health.
Taiwan R.O.C.; 4 Chang Gung University of Science and Technology,
Department of Respiratory Care, Chiayi, Taiwan R.O.C.; 5 Taipei
interest statement.
Chang Gung Memorial Hospital, Department of Obstetrics and
Gynecology, Taipei, Taiwan R.O.C.
E-PP0942 opment. They showed a negative reproductive profile, having no

Association of premenstrual living children due to a significant number of miscarriages (a data
syndrome with depression, sleep never previously reported). Women with a history of childhood
trauma also showed a higher rate of psychiatric outcomes, a smaller
quality, and sleep pattern in the number of living children and a significant number of miscarriages.
Korean female high-school student Fathers showed no psychiatric outcomes or personal factors that
M.Y. Chung may influence their partner’s outcome.
Worker’s Compensation Hospital/Yonsei Univ. College of Medicine, Conclusions.– Personality issues and childhood trauma clearly influ-
Dept. of Neuropsychiatry, Seoul, Republic of Korea ence psychiatric outcome after TToP in women. Men do not show
Background and aims.– Premenstrual syndrome (PMS) is known to psychiatric outcomes or personal factors that may influence in their
lower the quality of sleep and is associated with various psychi- partner’s outcome.
atric disorders. The aim of study was to investigate the relationship Disclosure of interest.– The authors have not supplied a conflict of
of PMS with depression, sleep quality, and sleep pattern in Korea interest statement.
female adolescents.
Methods.– Of 867 high school female students, 400 female subjects
were included in the study. All participants completed self-report E-PP0944
questionnaires including demographic variables, shortened pre- The burden of child abuse on perinatal
menstrual assessment form (SPAF), patient health questionnaire-9
mental health, the role and mediation
(PHQ-9), Pittsburgh sleep quality index (PSQI), Epworth sleepi-
ness scale (ESS), insomnia severity scale (ISI), Korean translated of victims’ personality disorders
composite scale (CS). A total of 394 individuals completed the ques- F. Pescatore1 , E. Di Giacomo2* , F. Colmegna3 , V. Placenti4 , R.
tionnaires were analyzed. Pessina4 , M. Clerici2
1 Psychiatric Residency Training Program – University of Milano –
Results.– There were differences in the CS, PHQ, PSQI and ESS
between PMS and non-PMS groups. Although PMS groups showed Bicocca Italy, Psychiatry, Monza, Italy; 2 ASST Monza-University of
more menstrual dysmenorrhea, no difference was found in bleed- Milano-Bicocca, Psychiatry, Monza, Italy; 3 ASST Monza, Psychiatry,
ing durationand cycle. PMS symptom had positive correlations Monza, Italy; 4 University of Milan-Bicocca, Psychiatry, Monza, Italy
with depression, sleep quality and excessive sleepiness in daytime.
There was no difference of sleep duration between groups, but PMS Background and aims.– Possible long term outcomes of child abuse
might have a relationship with eveningness type in sleep pattern. involve issues female victims experience during their pregnancy
Conclusions.– In Korean female high school students, the PMS and post-partum, both physically and psychologically. Likewise,
might constituterisk factors for depression, poor sleep quality, and child abuse is known as key factor for the development of person-
delayed circadian rhythm, and it might effect on daytime impair- ality disorders. Little is known about the outcomes of an interplay
ment by excessive sleepiness. An appropriate evaluation of PMS between child abuse and personality issues in perinatal.
could be helpful in mental health condition of the adolescents. Aims.– To analyze the interaction between child abuse (CA), vic-
Disclosure of interest.– The authors have not supplied a conflict of tims personality disorders (PDs) and the expression of psychiatric
interest statement. sufferance during the perinatal period.
Methods.– 150 women, consecutively admitted to the Perinatal
Psychiatric Outpatient Department were clinically evaluated and
E-PP0943
administered SCID II, CTQ, WHOQOL-BREF, EPDS, BDI and BAI. We
Maternal and paternal mental health randomized patients in affected or not by PDs and CA.
in therapeutic termination of Results.– CA increases the risk of post-partum depression in bor-
pregnancy: psychiatric history and derline PD (p = .027). Each type of child abuse induces different
outcomes perinatal psychiatric outcomes in the interaction with distinct vic-
R. Pessina1 , E. Di Giacomo2* , F. Colmegna3 , V. Placenti1 , F. tims personality disorders (e.g. sexual abuse influences the risk of
Pescatore4 , I. Group4 , M. Clerici2 post-partum depression in paranoid and schizoid PD [p = .035;.048]
1 University of Milan Bicocca, Psychiatry, Monza, Italy; 2 ASST and of anxiety in borderline [p = .027]).
Monza-University of Milano-Bicocca, Psychiatry, Monza, Italy; 3 ASST Conclusions.– Childhood abuse increases the risk of developing psy-
Monza, Psychiatry, Monza, Italy; 4 Psychiatric Residency Training chiatric illness during the perinatal period with the mediation of
Program – University of Milan-Bicocca, Psychiatry, Monza, Italy victims’ personality disorders, suggesting an eventual specificity of
* Corresponding author. those abuses on precise outcomes.
Background and aims.– The therapeutic termination of pregnancy interest statement.
(TToP) may have psychiatric outcomes like depression, anxiety
and post-traumatic stress disorder (PTSD). Personality issues, child-
hood traumas and paternal contribution and outcomes are too little E-PP0945
investigated. Features of self-esteem in mothers of
Aims.– Exploring the contribution of maternal personality disorders children with autism spectrum
and maternal history of childhood abuse to psychiatric outcomes
disorder
after a TToP, paternal psychiatric outcomes and their role on their
D. Dovbysh1,2* , M. Ermakova1 , E. Shishkina1 , M. Krivosheeva2
partner’s psychopathological and psychiatric outcomes. 1 Scientific-practical Children’s and Adolescents Mental Health Center
Methods.– 25 couples, with a prenatal diagnosis of fetal abnormal-
n.a. G. Sukhareva- Moscow Department of Health Care- Moscow-
ity, had a psychiatric evaluation for eligibility to TToP and after one
Russia, Psychiatry, Moscow, Russia; 2 Federal State Autonomous
year. Women and unborn fathers were also tested with HAM-D,
Educational Institution of Higher Education I.M. Sechenov First
HAM-A, BDI-II, PCL-5, IPDS, CTQ and CD-RISC-10.
Moscow State Medical University of the Ministry of Health of the
Results.– Women who initially showed important depressive symp-
Russian Federation Sechenov University, Faculty of Higher Nursing
toms, globally improved after one year, but 12% of them developed
Training- Psychology and Social Work, Moscow, Russia
PTSD (fewer than expected from Literature). Those affected by a * Corresponding author.
personality disorder improved significantly less, showing a higher
degree of pathological resilience and a higher rate of PTSD devel-
Background and aims.– Discovery of a child’s developmental dis- Conclusions.– There was a relation between attachment dimensions
order is a hard experience for parents. Study takes a look at and early maladaptive schemas in both groups, however amongst
self-esteem peculiarities of mothers of children with ASD and their victims this relationship reveals a greater dysfunctional character.
attitude towards discovery of diagnosis. Disclosure of interest.– The authors have not supplied a conflict of
Aim.– Studying the features of self-relationship of mothers, raising interest statement.
children with ASD.
Hypothesis of the study was the assumption that the mothers of
E-PP0947
children with ASD in the subjective assessment demonstrate dom-
ination of dissatisfaction with themselves. Relationship between
Methods.– Semi-structured interview; experimental psychological health-promoting behaviors and
technique “Dembo-Rubinstein”. quality of life in postmenopausal
Results.– For the majority of respondents, the unevenness of real women
self-esteem is combined with underestimation of marks of ideal M. Farahaninia1* , A. Alaeenejad1 , S. Janmohammadi1 , H. Haghani2
self-esteem. There is also a pessimistic assessment of their capabil- 1 Iran University of Medical Sciences and Health Services-,
ities, which manifests itself in the form of lowering the evaluation Community Health Nursing, Tehran, Iran; 2 Iran University of
of their potential opportunities to the level of real self-esteem. Medical Sciences and Health Services, Department of Biostatistics,
Most importantly, half of the subjects had extremely low scores Tehran, Iran
on the happiness scale. During the experimental conversation, * Corresponding author.
discussion of the scale of happiness was the most emotionally
charged. Women who placed a mark below the middle in this scale, Background and aims.– Menopause is one of the most important
explained this by the child’s health problems. For a group of moms stages of women’s life in the path of development which, comes
who do not yet know about the diagnosis, this range of experiences with a series of other problems. The health status and quality of
is not typical. life issues of the postmenopausal women are serious challenges
Conclusions.– Mothers of children with ASD demonstrate general for many health areas. The aim of this study was to determine the
dissatisfaction with themselves, a pessimistic view of their own relationship between health promotion behaviors and the quality
capabilities and the prevalence of feeling unhappy. The most dif- of life of postmenopausal women.
ficult period for mothers is the stage of diagnostics, which is Methods.– This descriptive-correlation study was performed on 200
accompanied by difficulties in accepting a diagnosis and various postmenopausal women in the west of Tehran. The armamen-
emotional dysfunctions. During this period women need special tarium for this study was a three-part questionnaire comprising
psychological support. demographic data, the second version of Health Promoting Lifestyle
Disclosure of interest.– The authors have not supplied a conflict of Profile (HPLP II) and Menopause-Specific Quality of Life (MENQOL).
interest statement. Data were analyzed by descriptive and inferential statistical tests
using SPSS V. 20.
Results.– The results showed that the mean score of health promo-
E-PP0946 tion behaviors was 2.49 ± 0.47 (in moderate level). More than half
Intimate partner violence: attachment of the participants had a good quality of life, an overall quality of life
and early maladaptive schemas mean score being 70.63 ± 37.49. The overall score of health promo-
among victims tion behaviors and quality of life was better in women who were
A. Dias, S. Simões, I. Garcia, C. Duarte* , H. Espírito-Santo, L. Lemos married, younger aged, with good economic status, employment
Instituto Superior Miguel Torga, Psychology, Coimbra, Portugal and those who achieved higher education.
* Corresponding author. Conclusions.– The results of Pearson correlation test showed that
there is a significant reverse correlation between quality of life
Background and aims.– The pattern of violence over an intimate and health promotion behaviors in the stress management dimen-
partner has been a serious concern over the years, and many sion (P = 0.013). Therefore educational programs are recommended
are the studies that try to understand the mental, physical and as an effective, economical and safe approach to reducing the
psychological consequences of this public health problem. Attach- menopause problems and augmenting the quality of life.
ment and establishment of significant early relationships begin in Disclosure of interest.– The authors have not supplied a conflict of
childhood, but its repercussions continue in adulthood as well as interest statement.
early maladaptive schemas, which can have a role in establish-
ing/maintaining relationships based on violence.
The objective of this study was to characterize the sample, to
describe the violence in the intimate relationship and the asso- E-Poster Presentation: Psychosurgery &
ciations between attachment dimensions and early maladaptive Stimulation Methods (ECT, TMS, VNS, DBS) - Part II
schemas.
Methods.– A sample of 98 women (49 victims and 49 non-victims),
aged between 18 and 80 years (M = 41.98, SD = 13.74) was collected. E-PP0948
Correlation and non-parametric tests were conducted to analyze Acceptability, safety & efficacy of
the relationship among the variables under study.
Results.– The two groups (victims vs. non-victims) showed differ-
transcranial magnetic stimulation
ences regarding age, marital status, and education level. Most of (TMS) during pregnancy
the victims under study are no longer in the violent relationship, R. Ogbuoji1* , A. Hernandez2
1 University of North Carolina, Public Health, Chapel Hill, USA; 2
although the average duration of the relationships is long and the
support from institutionsis recent. The overall sample presents Greenbrook TMS NeuroHealth Centers and Cognitive Psychiatry,
a secure attachment prototype, although the victims also reveal Psychiatry-Transcranial Magnetic Stimulation Center, Chapel Hill,
a frightened attachment prototype. The victims obtained higher USA
average values and a higher number of schemas than non-victims,
being them Self-sacrifice, Unrelenting Standards/Hypercriticism,
Negativity/Pessimism, Abandonment/Instability, Mistrust/Abuse,
Emotional Inhibition, Emotional Deprivation, and Subjugation.
Introduction.– TMS is a non-pharmacological treatment for Conclusions.– Adding non-invasive correction of ANS to standard
treatment-resistant depression (TRD). However, the safety and effi- medical therapy allows reducing the condition of children with
cacy of TMS use during pregnancy is not clear as very little research psychosomatic diseases described in the article.
evidence is available. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– Literature search (1995–2018) trough MEDLINE, interest statement.
GOOGLE SCHOLAR, Psych INFO, and SCOPUS using the search
terms: transcranial magnetic stimulation and pregnancy and
depression. 152 articles were generated; only fourteen met the E-PP0950
study criteria. No significant changes in the level of
Results.– Acceptability: Pregnant women usually prefer non- C-reactive protein in
pharmacological treatments. A study conducted in 2011 to access
treatment-resistant patients with
the acceptability of repeated TMS for treatment of MDD during
pregnancy found that TMS was considered an unacceptable option. paranoid schizophrenia during
However, after the women were shown an informational video, it electroconvulsive therapy
acceptability increased significantly. N. Petrova1* , M. Dorofeikova2 , D. Zubov3 , V. Dorofeykov4 , M.
Safety: The first case report conducted to access the safety of TMS Ivanov3
1 Saint-Petersburg State University, Department of psychiatry and
in pregnancy was in 1999. Several other studies have all reported
TMS to be safe for the mother with no observed major side effects narcology, Saint-Petersburg, Russia; 2 Sechenov Institute of
other than headache and scalp pain. TMS has not been shown to Evolutionary Physiology and Biochemistry, Laboratory of
be associated with adverse fetal outcome during pregnancy or in Neurophysiology and Pathology of Behavior, Saint-Petersburg,
the postnatal period. Russia; 3 Bekhterev National Medical Research Center of Psychiatry
Efficacy: TMS have been successfully used to relieve symptoms of and Neurology, Department of the Biological Treatment of the
MDD in pregnant women including TRD during the first, second Mentally Ill, Saint-Petersburg, Russia; 4 Lesgaft National State
and third trimester. University of Physical Culture- Sport and Health, Department of
Conclusions.– TMS acceptability increases with knowledge about biochemistry, Saint-Petersburg, Russia
the procedure. The use of TMS in pregnancy is an effective non-
pharmacological treatment for MDD. It is generally safe (for mother
Background and aims.– 10%-30% of patients with schizophre-
and child) and well tolerated with headache and dizziness reported
nia meet the criteria for treatment resistance, and 40%-70% of
as minor side effects.
them do not improve after clozapine therapy or it is terminated
due to adverse effects. The efficacy of electroconvulsive ther-
interest statement.
apy (ECT) in treatment-resistant schizophrenia is undeniable. At
the same time, data regarding its safety differ. The aim of this
E-PP0949 work was to study the dynamics of C-reactive protein (CRP) in
patients with treatment-resistant paranoid schizophrenia during
The effect of non-invasive stimulation
combined pharmacotherapy and ECT to identify possible inflam-
of the autonomic nervous system in matory response.
children with psychosomatic Methods.– 32 patients with treatment-resistant paranoid
disorders schizophrenia (13 women, mean age 31.4 ± 9.5 years, disease dura-
T. Petrenko tion 7.8 ± 6.6 years) and 41 patients with paranoid schizophrenia
Ural Federal University / Ural State Medical University, Institute of in remission (18 women, age 39.4 ± 9.1 years, disease duration
Radioelectronics and Information Technologies, Yekaterinburg, Russia 13.7 ± 9.1 years) were included. The serum levels of high sensitivity
Background and aims.– Modern studies show the important par- CRP were determined before the start of the procedures, a day
ticipation autonomic nervous system (ANS) in the development after the third and sixth ECT using automated Abbott analyzer.
of psychosomatic disorders. This article discussed the possibil- Results.– We have found no differences in the average level of
ity of correcting children’s psychosomatic disorders with the help CRP in the two groups of patients (3.1 ± 3.4 mg/l vs. 2.4 ± 3.7 mg/l,
of non-invasive electrical stimulation of ANS structures with the p = 0.374). The level of CRP of treatment-resistant patients at
“SYMPATHOCOR-01” neuroelectrostimulation device in complex three time points amounted to, respectively, 3.22 ± 3.46 mg/l,
therapy. 4.73 ± 5.61 mg/l, and 4.21 ± 5.48 mg/l (insignificant differences),
Methods.– Participated 83 children of both sexes from 5 to 14 years indicating the absence of emergence or amplification of the inflam-
old with following diagnosis: bronchial asthma (n = 34), atopic der- matory response.
matitis (n = 27), gastroesophageal reflux disease (n = 22). Data on Conclusions.– The absence of significant changes of this indicator
relevant diseases were evaluated by clinical methods. Baseline ANS confirms the safety of a combination of modern modified method
was assessed by the heart rate variability (HRV). All children were of ECT and pharmacotherapy in treatment-resistant patients with
randomly divided into two groups (n1 = 41; n2 = 42). The entire paranoid schizophrenia.
observation period was 21 days. Both groups received standard Disclosure of interest.– The authors have not supplied a conflict of
medical therapy prescribed by a pediatrician. The second group was interest statement.
given additional daily therapy with a SYMPATHOCOR-01 device for
2 weeks. Evaluation of the state of children after the observation
period was carried out according to the same criteria as the original E-PP0951
one. Analysis of cardiac action potential
Results.– Clinical trials showed that most children (78%) had inhomogeneities in patients treated
increased baseline ANS activity, which correlated with the sever- with electroconvulsive therapy
ity of somatic manifestations. After two weeks of complex therapy M. Próchnicki1* , P. Kiciński2 , H. Karakuła-Juchnowicz1
improving the clinical condition was observed in most children 1 Medical University of Lublin, Department of Psychiatry-
in the group with neuroelectrostimulation device. This is consis- Psychotherapy and Early Intervention, Lublin, Poland; 2 Medical
tent with the HRV analysis: LF/HF ratio for the first group changed University of Lublin, Department of Experimental Hematooncology,
from 7.71 ± 4.54 to 5.82 ± 6.28; for the second group - significantly Lublin, Poland
decreases from 8.21 ± 5.82 to 2.12 ± 4.53. * Corresponding author.
Background and aims.– Electroconvulsive therapy (ECT) is a highly This non-invasive neurostimulation technique has been well toler-
effective treatment for severe and drug-resistant forms of mental ated in our population.
disorders. ECT complications are rare, but mostly concern acute Conclusions.– The TMT A and B and the verbal Fluency Test assess
cardiovascular episodes. Recent studies indicate the usefulness of the initiation and the flexibility which are often impaired in autism.
digital ECG analysis in assessing the risk of cardiovascular death, If these results were replicated, the tDCS could be an easy and well-
arrhythmias and the development of heart failure. These parame- tolerated additive treatment in order to improve the quality of life
ters have not been studied so far in patients undergoing ECT. and the autonomy of autistic patients.
Objectives.– Assessment of the effect of ECT on selected electro- Disclosure of interest.– The authors have not supplied a conflict of
cardiographic parameters associated with an increased risk of interest statement.
cardiovascular death, i.e. duration of ventricular complex (QRSd),
duration of the corrected QT interval (QTc) and spatial angle QRS-T
(QRSTA). E-PP0953
Methods.– The study included 40 patients (28 men) aged 36.9 ± 16 Can deep brain stimulation lead to
years, qualified for ECT due to drug-resistant schizophrenia or symptom remission in
depression. Patients were referred to series of 12 bilateral ECT using
treatment-resistant patients with
the Thymatron System IV. The recording and analysis of ECG param-
eters and spatial vectors were carried out using the GE MAC5500 obsessive-compulsive disorder? case
digital device. The study group included patients without cardio- study of three obsessive-compulsive
vascular diseases (excluding hypertension, n = 8). patients treated with deep brain
Results.– There were no statistically significant differences of stimulation
QRSTA before and after ECT treatment (41.1 ± 18.9 vs 42.4 ± 9◦ , D. Siwicki1* , J. Beszłej Aleksander1 , A. Weiser2 , P. Piotrowski1 , K.
p = 0.09). Similarly, no differences were observed in the QRSd val- Fila-Witecka1 , T. Wieczorek1 , P. Tabakow2 , J. Rymaszewska1
ues (92.8 ± 5.6 vs. 94.9 ± 5.8 ms, p = 0.74) and QTc (430.2 ± 26.4 vs 1 Wroclaw Medical University, Department of Psychiatry, Wroclaw,
425.8 ± 19.6 ms, p = 0.11). The concentration of high-sensitivity tro- Poland; 2 Wroclaw Medical University, Department of Neurosurgery,
ponin T before the initiation of ECT was 0.008 ± 0.006 ng/ml and Wroclaw, Poland
did not significantly differ from the concentration after the therapy * Corresponding author.
(0.008 ± 0.004 ng/ml, p = 0.36).
Conclusions.– Our results indicate high safety of ECT in patients with Background and aims.– Deep Brain Stimulation (DBS) is an increas-
low baseline cardiovascular risk. ingly popular method of treatment in severe, drug-resistant
Disclosure of interest.– The authors have not supplied a conflict of psychiatric disorders, especially in Obsessive Compulsive Disorder.
interest statement. As around 10% of patients are resistant to standard treatment (phar-
macotherapy, psychotherapy) and remain severely disabled, DBS
gets more attention of researchers and clinicians.
E-PP0952 The aim of this presentation is to try answering the question “What
Pilot study investigating the effect of is the influence of different personality traits and baseline level of
cathodal transcranial direct current general functioning of patients with OCD on the effectiveness of
DBS?”.
stimulation (TDCS) on the executive
Methods.– In this pilot study we have enrolled three patients suf-
functions of patients with autism fering from treatment-resistant OCD and provided a successful,
without intellectual disability. bilateral implantation of electrodes into nucleus accumbens (NAc)
Transfex study and ventral part of the anterior limb of internal capsule (vALIC).
M. Rotharmel1* , V. Moulier1 , M. Vasse1 , I. Mirea-Grivel1 , G. There were no complications or adverse events of surgery. Patients
Opolczynski1 , A. Rosier2 , O. Guillin1 remained in pharmacological treatment, had possibility to get
1 Rouvray Hospital, University Department of Psychiatry, involved in CBT treatment. They were also regularly scored and
Sotteville-lès-Rouen, France; 2 Rouvray Hospital, Centre Ressource observed in period of at least 6 months.
Autisme Normandie Seine Eure, Sotteville-lès-Rouen, France Results.– Mental state improvement differed, depending on the
* Corresponding author. patient and period of stimulation, between 12% and 68% of Y-BOCS
score reduction.
Background and aims.– Executive functions (EF) are often impaired Conclusions.– Remission of obsessive and compulsive symptoms
in autism spectrum disorder (ASD). Such dysfunctions are asso- was partly independent from the stimulation parameters, and as
ciated to anxiety, depression and a lack of autonomy. We well as changes in general functioning, was related to personal-
hypothesized that cathodal tDCS could improve the executive func- ity traits and level of insight. These factors influenced motivation
tions of autistic adults without any intellectual disability. Such (escpacialy in area of fulfilling social roles), quality of relationships
enhancement could improve their adaptive behaviors. and compliance to provided synergistic treatment options (phar-
Methods.– Eight patients with high-functioning ASD received 10 macotherapy, cognitive-behavioral therapy).
consecutive cathodal tDCS sessions (2 mA) in an open trial over Disclosure of interest.– The authors have not supplied a conflict of
the left dorsolateral prefrontal cortex (F3) for 15 minutes each. interest statement.
Measures of EF (Stroop test, Trail Making Test A and B, Modified
Wisconsin Card Sorting Test and category and letter verbal Fluency
Test) and behavioral dysexecutive syndrome battery (Behav- E-PP0954
ioral Dysexecutive Syndrome Inventory, BDSI, and Repetitive and Combined electroconvulsive therapy
Restricted Behaviours scale, RRB) were administered before and at
and transcranial magnetic
10 days of post-treatment.
Results.– The results showed significant decreases in TMT A and stimulation in pharmaco-resistant
B (time B, gain of 12 seconds, p = 0.01) and improvement in let- depressive disorders
ter verbal Fluency Test (p = 0.02). The intensity of the domains 1 M. Tukala* , T. Dakukina, T. Budko, P. Korolevich
(hypoactivity) and 2 (difficulties in initiation of activities) about Republican Research and Practice Center for Mental Health,
BDSI has significantly decreased (p = 0.02) as well as the average Department of Mental and Behavioural Disorders, Minsk, Belarus
score about RRB (28.12 before and 21.62 after treatment; p = 0.01).
Background and aims.– Electroconvulsive therapy (ECT) is the Disclosure of interest.– The authors have not supplied a conflict of
longest standing psychiatric method, particularly in severe depres- interest statement.
sion. However, this treatment comes with a number of side effects
such as memory impairment. Transcranial magnetic stimulation
(TMS) is non-invasive promising technique for the cerebral cortex, E-PP0956
which promotes activation of neuroplasticity and improvement of Severity of psychotic depression - a
cognitive functions. better predictor for responsiveness to
To evaluate the efficacy and safety of combined ECT and TMS in the
ECT than the mere presence of
treatment of pharmaco-resistant depressive disorders.
Methods.– 46 patients (14 males and 32 females) with pharmaco- psychotic symptoms?
resistant depressive disorders (F31-F33) where divided on three L. Van Diermen1* , P. Versyck1 , S. van den Ameele1 , Y. Madani2 , T.
groups: the main one (12 people) - ECT by bilateral (bitemporal) Vermeulen2 , E. Fransen3 , B. Sabbe1 , R. van der Mast4 , T.
method, alternating every other day with sessions of low-frequency Birkenhäger5 , D. Schrijvers1
1 UAntwerpen, Faculty of Medicine and Health Sciences, Antwerp,
(0.9 Hz) TMS on the right dorsolateral prefrontal cortex; 1st com-
parison group (18 people) - only daily sessions of low-frequency Belgium; 2 PZ Duffel, Old age psychiatry, Duffel, Belgium; 3
(0.9 Hz) TMS; the 2nd comparison group (16 people) - only ECT (2–3 UAntwerpen, StatUA center for statistics, Antwerp, Belgium; 4 Leiden
sessions per week, course 8–12 sessions). The statistical analysis University Medical Center, Department of Psychiatry, Leiden, The
of Hamilton Depression Rating Scale (HAM-D-21) scores, Schulte Netherlands; 5 Erasmus University Medical Center, Department of
Table was performed. Psychiatry, Rotterdam, The Netherlands
Results.– After a combined ECT and TMS decrease in the severity
of depressive symptoms was observed in HAM-D-21 by 68.2% per- Background and aims.– The mere presence of psychotic symptoms
sons, in the 1st comparison group by 57.1%, in the 2nd comparison is an important predictor for responsiveness of electroconvulsive
group - by 63.6% (p < 0.05). The main and the 1st group of compari- therapy (ECT) in psychotic depression. It is unknown whether a
son improved the indicators of voluntary attention and the volume continuous severity measure is an even better predictor. This study
of short-term memory. The improvement was maintained for 4 Therefore, we investigated whether severity of psychotic depres-
months. sion as measured with the Psychotic Depression Assessment Scale
Conclusions.– The combined use of ECT and TMS has a neuromod- (PDAS) is a better predictor of responsiveness to ECT than the mere
ulatory effect on the cognitive domain. This is an effective and safe presence of psychotic symptoms.
method for treatment of pharmaco-resistant depressive disorders. Methods.– Total group consisted of 33 patients with psychotic
Disclosure of interest.– The authors have not supplied a conflict of depression (PD) and 40 depressed patients without psychotic
interest statement. symptoms (non-PD). Depression severity was assessed with the
Montgomery-Asberg Depression Rating Scale (MADRS) at baseline
and after the last ECT treatment. Logistic regression models for
E-PP0955
MADRS response and remission were fitted, with either the PDAS
The maudsley staging method as or the dichotomous predictor ‘presence of psychotic’ symptoms as
predictor of electroconvulsive therapy independent variables. Age, episode and treatment resistance were
effectiveness in depression added as covariates.
L. Van Diermen1* , K. Hebbrecht1 , D. Schrijvers1 , B. Sabbe1 , E. Results.– Both presence of psychotic symptoms and a higher total
Fransen2 , T. Birkenhäger3 PDAS-score favoured treatment MADRS-response. Also, MADRS-
1 UAntwerpen, Faculty of Medicine and Health Sciences, Antwerp, remission was predicted by mere presence of psychotic symptoms
Belgium; 2 UAntwerpen, StatUA Center for Statistics, Antwerp, and higher PDAS-score. Age was an essential contributor to the pre-
Belgium; 3 Erasmus University Medical Center, Psychiatry, diction models, with greater chances at response and remission for
Rotterdam, The Netherlands older patients. PDAS scores decreased significantly during ECT. Of
* Corresponding author. the total study group, 81.5% reached response and 63.9% remission
according to the PDAS.
Background and aims.– To investigate the potential role of the Conclusions.– The PDAS can predict response and remission to ECT
Maudsley Staging Method (MSM) in the prediction of electrocon- in depression, but appears to have no clear advantage over knowing
vulsive therapy (ECT) outcome in severely depressed adults. whether psychotic symptoms exist or not. Particularly (higher) age
Methods.– Between August 2015 and August 2017, 73 consecutive was of great importance in predicting responsiveness to ECT.
patients with a major depressive episode (DSM-IV-TR) scheduled Disclosure of interest.– The authors have not supplied a conflict of
for ECT were recruited. Prior to their first ECT session, the MSM was interest statement.
completed to assess the level of therapy resistance. To determine
the reduction in depression severity and response and remission
rates, symptom severity was assessed at baseline and within one E-PP0957
week after the last ECT session using the 17-item Hamilton Depres- Prefrontal alpha asymmetry index is
sion Rating Scale (HDRS17).
correlated with treatment response to
Results.– The percentage of symptom reduction following ECT was
best predicted by the MSM episode duration and depression sever- acute 20 Hz rTMS over left frontal
ity factors (R2 completer sample 0.24). Episode duration alone was cortex
the best predictor of remission (area under the ROC curve for com- A. Yadollahpour1* , A. shakeri1 , R. rostami2 , R. kazemi2
1 Ahvaz Jundishapur Univeristy of Medical Scineces, Ahvaz, IRAN,
pleters: 0.72). Adding age to the models increased their predictive
capacity. Medical physics, Ahvaz, Iran; 2 University of Tehran, Psychology
Conclusions.– An adapted version of the MSM gauging shorter Department, Tehran, Iran
episode duration, more severe depressive symptoms and older age
is significantly associated with ECT effectiveness in adults with
Background and aims.– EEG asymmetry index (AI) may be correlated
severe recurrent depression and is thus highly suitable for use in
with depression. This study aims to comparatively investigate the
clinical practice, promoting the shared treatment decision-making
effects of acute rTMS on alpha AIs in different brain regions in the
process.
responders and non-responders.
Methods.– This open label clinical trial conducted on patients Conclusions.– These findings provide evidence of improved parental
(n = 12) with intractable major depression. The patients received expressed emotion in response to this family-based intervention
ten sessions of 20 Hz rTMS over left dorsolateral prefrontal cortex for eating disorders in adolescents. Favoring the emotional climate
in an acute regimen of daily double sessions of 2 hours apart. Each and attitudes to significant others in families affected with eating
session consists of 60 trains with 2.5 seconds inter-train interval at disorders may also be associated with better treatment outcomes.
120% motor threshold for 5 consecutive days. Nineteen-channels Disclosure of interest.– The authors have not supplied a conflict of
EEG were recorded prior and post intervention. The treatment interest statement.
response was evaluated with Hamilton depression rating scale
(HAM-D) to divide the participants into responders and non-
responders for further assessments. The alpha AIs of prefrontal E-PP0959
(Fp1-Fp2), mid-frontal (F3-F4), mid-lateral (F7-F8), and temporal Psychotherapy in complex treatment
(T3-T4) regions were calculated and compared within and between of patients with opiate addiction with
groups.
low motivation for treatment
Results.– In the responder (n = 4) group, the AI of Fp1-Fp2 was
I. Belokrylov, M. Artemieva, A. Bryukhin, R. Suleimanov, I. Danilin* ,
significantly reduced after treatment (P < 0.05). In addition, com-
A. Lazukova
pared to non-responders, the AI in the responders was significantly
Peoples’ Friendship University of Russia RUDN University,
reduced after treatment. Interestingly, there was a direct rela-
Department of psychiatry and medical psychology, Moscow, Russia
tionship between the amount of treatment response with the * Corresponding author.
magnitude of AI change. The F3-F4 and F7-F8 AIs were also reduced
in the responders, but these reductions were not significant. The Background and aims.– Introduction. Opium dependence in many
temporal AI showed no change. The non-responders (n = 8) did not cases shows a high resistance to most treatment methods. One of
show any significant change in alpha AIs in any brain region. the main reasons for this situation is the low motivation of patients
Conclusions.– Alpha AI of prefrontal cortex may be a predictor of for treatment.
the treatment response to rTMS in patients with depression. Objectives.– Identification of clinico-psychopathological and per-
Disclosure of interest.– The authors have not supplied a conflict of sonal factors associated with low motivation for treatment in
interest statement. patients with opiate dependence; the development of a psy-
Disclosure of interest.– The authors have not supplied a conflict of chotherapeutic technique aimed at the formation and maintenance
interest statement. of motivation to abandon the drug and, as a consequence, improv-
ing the effectiveness of treatment of this contingent.
Methods.– A total of 75 patients with opiate addiction were exam-
ined, all men, with an average age of 25.6 ± 3.2 years. On the basis of
E-Poster Presentation: Psychotherapy factorial and correlation analysis, two clinical-pathopsychological
markers are established, reliably associated with the level of moti-
vation for treatment. The first is the degree of severity of the
E-PP0958 pathological attraction to the drug, the second is the degree of
Improved parental expressed emotion self-awareness of the unity of I. An integrative psychotherapeu-
in a family-based intervention for tic method was developed to increase the motivation of addicts
for treatment, focused on working with the functions of self-
adolescents with eating disorders
awareness. Efficacy evaluation was conducted in a randomized
A.L. Barrios-Hernandez1* , A. Blanco Fernandez1 , M. Graell-Berna2 ,
controlled trial.
G. Gonzalez-Cuevas1
1 European University of Madrid, Psychology, Madrid, Spain; 2 Results.– The use of the developed method led to more than twofold
excess of the number of remissions of addiction over 1 year in the
Hospital Infantil Universitario Niño Jesus, Servicio de Psiquiatria y
main group compared to the control group.
Psicologia, Madrid, Spain
* Corresponding author. Conclusions.– Psychotherapy, aimed at strengthening the motiva-
tion of patients with opiate dependence on treatment, significantly
Background and aims.– Family-based therapy for eating disorders increases the effectiveness of the treatment complex.
is one of the most effective forms of treatment for adolescents. The publication was prepared with the support of the “RUDN Uni-
Expressed emotion has also been shown to modulate treatment versity Program 5–100”.
outcome for these patients. However, little is still known about Disclosure of interest.– The authors have not supplied a conflict of
how family characteristics such as parental expressed emotion interest statement.
may impact family health and functioning on adolescent progno-
sis. Therefore, our aim was to investigate whether parents whose
daughters present ED improve on expressed emotion as a result of E-PP0960
a family-based intervention. Therapy by theater as a method of
Methods.– One hundred and twenty-three parents whose daughters rehabilitation for families raising
presented ED and received group therapy treatment at Niño Jesus children with mental disorders
hospital in Madrid participated in this randomized experiment. D. Dovbysh1,2* , M. Bebtschuk1 , E. Dzavadova1 , Y. Zhorina2
Whereas the experimental group was subjected to a family-based 1 Scientific-Practical Children’s and Adolescents Mental Health Center
training (8-week sessions for about 2 hours), the control group had n.a. G. Sukhareva, Moscow Department of Health Care, Moscow-
no training. Before and after this training (or the same amount of Russia, Psychiatry, Moscow, Russia; 2 Federal State Autonomous
time for the control group), parents were administered the Level of Educational Institution of Higher Education I.M. Sechenov First
Expressed Emotion (LEE) scale. Moscow State Medical University of the Ministry of Health of the
Results.– The family-based intervention improved parental expres- Russian Federation Sechenov University, Faculty of Higher Nursing
sion emotion. Specifically, there were significant reductions in the Training, Psychology and Social Work, Moscow, Russia
levels of intrusiveness and hostility (near statistical significance) * Corresponding author.
of parents belonging to the experimental group. No significant dif-
ferences were found, though, for the other dimensions: emotional Background and aims.– The prevalence of the biopsychosocial
response, attitude toward illness, and tolerance. approach in psychiatry inevitably entails the active implementa-
tion of the principles of psychosocial rehabilitation, the purpose of only pharmacological intervention. Further research is needed to
which is to integrate the patient into society and prevent disability. evaluate improvement in quality of life and sexual functioning.
Therapy by theater is one of the most beautiful and effective ways Disclosure of interest.– The authors have not supplied a conflict of
of social and psychological rehabilitation. interest statement.
To study and develop recommendations for non-drug treatment
(art therapy) and medical rehabilitation of mentally ill children to
the micro- and macroenvironment. E-PP0962
Methods.– Family sociogram; Olson’s adaptation and cohesion test; Beyond talking-cure - the body takes
questionnaire “The child through the eyes of parents”; parent’s the burden: a reflection of modern
composition “My child”.
bodytherapy in the work with
Results.– For one year, 274 children and 52 families attended the-
atrical performances in various Moscow theaters. Embedding a traumatic stress
family visit to the theater in the process of family psychotherapy, J. Fuhrmann
followed by a discussion of gained experience with the psychol- Europen Transpersonal Association, Board of Directors, Schaffhausen,
ogist, becomes an effective tool for the following changes in the Switzerland
family system: 1) increasing the level of family cohesion; 2) change
of parental ideas about the possibilities of a sick child; 3) the nor- Background and aims.– In western psychotherapy, the human body
malization of the family hierarchy, which, in the conditions of a still leads a shadowy existence. Health insurance-financed thera-
serious illness of the child, is often disrupted; 4) the formation pies are largely based on language-based and cognitive methods.
and development of new ways of coping with the state of the Emphasis is placed on interpreting, categorizing and recognizing,
child. rewarding and frustrating as well as training and practicing new
Conclusions.– Therapy by theater, taking into account the great pos- behaviors. However, modern trauma research shows vividly that
sibilities of this project, should maximize the development of the the body and with it also the older parts of the brain has an essential
personality, which does not stop even in the situation of the disfunction in processing as well as in dealing with phenomena experi-
ease, and also provide conditions for the successful socialization of enced as traumatic. This in turn means that above all dysfunctional
children and adolescents hospitalized in a psychiatric hospital, and mechanisms, which were intended to cope with a traumatic situa-
for their families. tion, also have to be resolved on the physical/ somatic level so that
Disclosure of interest.– The authors have not supplied a conflict of the organism can return to its self-regulatory order or organismic
interest statement. self-regulation. The presentation aims to provide insight into the
history of bodyoriented Psychotherapy to modern approaches of
respiratory therapy, bodywork, neurogenic trembling and somat-
E-PP0961
ically oriented trauma interventions that can empower clients to
Treating mild to moderate psychiatric re-release traumatic stress from their organism and activate their
disorders: integrating psychotherapy own resilience.
in outpatient setting, a “brief Methods.–
®
intervention model” - Tension & Trauma-Releasing-Exercises (TRE )
- Holotropic Breathwork TM
F. Facchini* , M. Petrizzelli, P. Palmiotti, A. Foiadelli, G. Gallino
Asl Città Di Torino, Asl Città Di Torino, Turin, Italy - Gestalt-Bodytherapy
* Corresponding author. Results.– The language-based approaches, which often took place
in advance over many sessions, certainly provided a solid basis for
Background and aims.– Request of fast resolution of mild to this, but at a certain point did not solve the issue for many clients.
moderate anxiety and depressive disorders (mtmad), is high in ital- Conclusions.– We need a new, holistic understanding in psychother-
ian outpatient mental care services. Difficulties to treat mtmad apy, which fully integrates the body again. Furthermore, we need
patients, often high demanding to general practitioner, leads to doctors, psychiatrists, therapists who are ready to go this way
overload of psychiatric services particularly since, in contrast with themselves - with their own “body” - in order to be able to accom-
guidelines, the most common treatment is intended as pharmaco- pany clients and patients in the best possible way authenticly.
logical. Disclosure of interest.– The authors have not supplied a conflict of
Our aim: to evaluate counseling and brief focused psychotherapies interest statement.
(cbf - cognitive and psychodinamically oriented brief interven-
tion model), in improving global functioning, among a sample of
patients treated in a public mental health service. E-PP0963
Methods.– after first psychiatric assessment and diagnosis of Mindfulness-based cognitive therapy
mtmad, patients were sent to psychologists by case manager (MBCT) in the treatment of major
psychiatrist. In the year 2017 we recruited 49 adult patients
depression. Preliminary evidence for
(44,21 ± 18,36 y.o.) affected by mtmad (20% general anxiety dis-
order, 80% mild to moderate depressive disorder), we assessed its effectiveness and mechanisms of
socio-demographic data and evaluated global functioning at the change, an RCT study
beginning and at the end of cbf intervention with GAF score. P. Holas1* , I. Krejtz2 , M. Rusanowska3 , J. Nezlek4
1 University of Warsaw, Psychology, Warsaw, Poland; 2 University of
Results.– Psychotherapies started three weeks after first psychi-
atric appointment (18,41 ± 17,33 days of waiting list) and lasted Social Sciences and Humanities, Psychology, Warsaw, Poland; 3 Polish
two months (5,07 ± 4,07 clinical interviews). Significant improve- Academy of Sciences, Psychology, Warsaw, Poland; 4 University of
ment (GAF 4,30 ± 3,10 t(48) = 9, 71 p < 0.01) was noticed before Social Sciences and Humanities, Psychology, Poznan, Poland
and after intervention.
Conclusions.– Despite guidelines and possibility to hire well trained
Background and aims.– Major Depressive Disorder (MDD) is a per-
psychotherapists, use of psychotherapies to treat mtmad is under
vasive disorder estimated to be the leading cause of disability
utilized in Italian outpatient mental care services. In our study we
worldwide. Although current treatments lead to improvement in
outlined how cbf intervention can lead to improvement with impli-
majority of depressed individuals, more needs to be known about
cations of less side effects and better cost efficacy compared to
new therapies modalities and their mechanisms of action. Although
mindfulness-based cognitive therapy (MBCT) has been found to be E-PP0965

effective in preventing the relapse of recurrent depression, it is not The possibility of psychotherapy of
clear if MBCT is effective for currently depressed individuals.
anxious and depressive disorders in
Objectives.– The aim of the current research was to evaluate if MBCT
can reduce depressive symptoms and to assess mechanisms under-
patients at distant stages of brain
lying such changes. injury
Methods.– 56 individuals with a diagnosis of MDD were randomly G. Ivanova* , B. Tsygankov, U. Gadzhieva
assigned to MBCT (n = 26) and Waiting List (n = 30) conditions. A.I. Yevdokimov Moscow State University of Medicine and Dentistry,
Prior and post 8 weeks intervention they completed question- Department of Psychiatry, Narcology and Psychotherapy of the
naires, maintained a diary for 7 days, and unscrambled a list of Faculty of Additional Professional Education, Moscow, Russia
scrambled sentences as a measure of their depressive interpreta-
tion bias (Scramble Sentences Test, SST) with eye movements being
Background and aims.– Patients with exogenous organic pathology
recorded during task.
of the brain have an increased vulnerability to psychotrauma and
Results.– We found reduction in depressive symptoms, together
exogenous hazards in combination with the asthenic syndrome.
with increase in mindfulness in MBCT group. After MBCT, partici-
This requires a special approach in the treatment of such patients.
pants perceived events as more positive and less stressful, and they
It was intended to study the possibilities of using psychotherapy
used significantly fewer negation and discrepancy words. More-
in complex therapy of neurotic disorders that developed at remote
over, they made more positive interpretations in the SST than
stages of exogenous organic pathology of the brain.
before training, fixated less on negative keywords and more on
Methods.– A. Beck’s depression scale, A. Beck’s anxiety scale,
positive keywords than at the pre-test. No such differences were
SCL-90-R psychopathology scale, Wayne vegetative disturbance
found for the waiting group.
questionnaire, the scale of self-evaluation “State of health. Activ-
Conclusions.– These findings suggest that MBCT can be effective
ity. Mood” were used for diagnosis. Two groups of patients were
in treating current depression and indicate possible mechanisms
examined: a control group (65 people), in which only standard
underlying therapeutic change.
psychopharmacotherapy was performed, and the main group (49
people), in which standard therapy was combined with complex
interest statement.
psychotherapy. A specially developed program of psychothera-
peutic correction was based on methods of cognitive-behavioral
E-PP0964 therapy, relaxation techniques, and was conducted in a group for-
mat.
Mindfulness and ADHD: does it really Results.– In the main group, 87.8% of patients showed a decrease in
work? anxiety and vegetative disorders after treatment, in contrast to the
P. Horta* , A.T. Pereira, J.D. Rodrigues, M. Araújo control group. Also depressive symptoms and explosiveness reduc-
Centro Hospitalar Vila Nova de Gaia/ Espinho EPE, Psiquiatria, ing, subjectively assessed well-being improving, activity increasing
Portugal, Portugal were noted. When examining patients after 1.5 years, the stable
effect of the proposed therapeutic model was noted in 52.4% of
cases in the main group and only in 38.2% of cases in the control
Background and aims.– Attention Deficit Hyperactivity Disorder
group.
(ADHD) is a neurobiological disorder characterized by inatten-
Conclusions.– The proposed combination of psychopharmacother-
tion, hyperactivity and/or impulsivity. Almost 8% of children aged
apy and psychotherapy was effective for relieving anxiety,
between 4 and 17 years, and 4,4% of adults aged between 18 and
depressive symptoms and vegetative disorders in patients with
44 years match the criteria for this diagnosis.
exogenous organic pathology of the brain.
Mindfulness is defined as paying nonjudgmentally attention to
the present moment. Mindfulness training can improve atten-
interest statement.
tion regulation and evidence of mindfulness training for children,
adolescents and adults with ADHD is growing. The aim of this
study is to evaluate the effects of mindfulness training as a non- E-PP0966
pharmacological treatment for children, adolescents and adults
with ADHD. Integration of psychotherapy in the
Methods.– A non-systematic Pubmed/MEDLINE search was con- mental health service – three decades
ducted using the terms: “Attention Deficit Hyperactive Disorder”, of lithuanian experience
“ADHD”, “mindfulness”, “meditation” and “attention”. The research E. Laurinaitis
was limited to articles published in the last 8 years. Vilonius University, Department of Psychiatry, Vilnius, Lithuania
Results.– Mindfulness -based intervention is more commonly used * Corresponding author.
in adults than in children and adolescents. Studies show signifi-

cant improvement in attention in adult ADHD patients. One study Background and aims.– History of psychotherapy in Lithuania may
shows preliminary evidence for the effectiveness of mindfulness be traced from early 30-ies of XX century, but till middle 70-
for children with ADHD and for their parents, as rated by par- ies it remained a profession of a few, and they practiced it very
ents. Three studies supported that mindfulness-based training is often in hiding. However, in 1976–1977 the small group of 13–15
of clinical value for adolescents with ADHD. enthusiasts entered the field from both medical and psychology
Conclusions.– Mindfulness-based intervention is an effective treat- backgrounds first with self-education activities. From 1980 it grew
ment approach to improve attention deficits in adult ADHD into much wider yearly Vilnius Spring seminars, which collected
patients. It is still arguable whether mindfulness-based interven- over hundred of participants from all over former Soviet Union.
tion is effective for children and adolescents with ADHD due to Methods.– From late 70-ies an in-patient department for neurotic
limited data. More studies are needed to confirm the efficiency of disorders was opened in Vilnius Psychiatric Hospital, and in 1990
this approach in children and adolescents with ADHD. was established Vilnius Clinical Psychotherapy Center. However, it
Disclosure of interest.– The authors have not supplied a conflict of was dismantled in 2002, and till now hardly any similar structure
interest statement. was created.
Results.– Psychotherapy as a specialty in Lithuania was growing
and developing detached from mental health service, and some
reasons for this will be discussed. There were numerous attempts E-PP0968
to formally and legally formalize the training and practice of psy- Applying the matrix, a machine
chotherapy inside and outside the state-financed mental health
learning based tool, for enhancing
system, but till now it has failed.
Conclusions.– Main standard for the training of psychotherapists supervision in
in Lithuania is European Certificate of Psychotherapy, and oldest psychodynamic-oriented
local school of psychotherapy – Individual Psychodynamic Psy- psychotherapy
chotherapy course at Vilnius University – uses this standard since S. Mendlovic
the beginnings in 1992. However, how rigorous the requirements Shalvata Mental Health Center, General Office, Hod HaSharon, Israel
for the training are – it still hardly persuades both decision makers * Corresponding author.
and our colleagues psychiatrists, that these professionals are per-

fectly fit to work together in the service of patients and clients in Background and aims.– The complexity of psychotherapy poses
the mental health field. a great obstacle for researchers. Dynamic psychotherapy con-
Disclosure of interest.– The authors have not supplied a conflict of tains a vast range of occurrences, conscious and unconscious,
interest statement. relating to actions, thoughts, and emotions of both patient and
therapist. The MATRIX is a non-dogmatic measure that enables
algorithmic, moment-by-moment coding of psychodynamic-
E-PP0967 oriented psychotherapies. It sequentially codes fragments by their
Effectiveness of a shorter focus (patient/therapist/dyad) and dimension (potential-/content-
/interrelation of experiences) (Figure 1). Machine-learning proce-
mindfulness-based cognitive therapy dures applied on MATRIX sequences were shown to fully-explain
for patients with a current major the outcome of psychotherapy. Thus, a gentle adaptive stochas-
depressive episode:a tic boosting classification model perfectly distinguished between
randomized-controlled trial successful and unsuccessful treatments.
M.S. Li1* , G.C.L. Hung2 Our objective is to explore the possible use of the MATRIX in
1 Taipei City Hospital Zhongxiao Branch, Psychiatry department, enhancing supervisions in psychotherapy.
Taipei City, Taiwan R.O.C.; 2 Blossom Clinic of Psychosomatic Methods.– A publicly available segment of psychotherapy was
Medicine, Department of Psychiatry, Taipei, Taiwan R.O.C. MATRIX coded, and analyzed a the MATRIX-derived structured
* Corresponding author. supervision enhancer-tool.
Results.– Applying the MATRIX-derived structured supervision
Background and aims.– There is evidence that, apart from prevent- enhancer-tool illuminated theoretical, clinical and technical issues
ing relapse of depression, mindfulness-based cognitive therapy essential to therapy. These are discussed for advantageous and lim-
(MBCT) may reduce symptom severity for patients with a current itations.
major depressive episode (MDE). However, dysfunctions related to Conclusions.– Combining innovative tools of representation and
depression could present a barrier to people engaging in the MBCT coding (the MATRIX) with powerful computational models formal-
program in its full length. The purpose of the current study was to izing patient-therapist interactional processes (machine-learning
compare the efficacy of a shorter MBCT (s-MBCT) plus treatment strategies) has the potential to translate knowledge to practice.
as usual (TAU) to TAU alone for patients with major depressive Thus, the MATRIX, and tools alike, could contribute in designing
disorder in a randomized controlled trial. psychotherapeutic processes that improve outcome, and in the
Methods.– S-MBCT involved 8 weekly, 1.5-hour group sessions. future may pave the way for developing data-driven predictive
Major adjustments included shortened mindfulness practices, models assisting in computer-assisted, or automated, psychother-
reduced didactic contents and increased movement practices. Mea- apies.
surements of depression (Beck Depression Inventory, BDI) and level Disclosure of interest.– The authors have not supplied a conflict of
of mindfulness (Five Facet Mindfulness Questionnaire, FFMQ) were interest statement.
completed at baseline and at 8 weeks.
Results.– Forty-seven patients (women = 33, 70%) with a cur-
rent MDE were included. Participants receiving s-MBCT plus TAU E-PP0969
(n = 26) did not differ from those with TAU only (n = 21) with respect Coping mechanisms and self-efficacy
to demographic characteristics, severity of depression and level of
of patients treated with group
mindfulness at baseline. A significant between group differences
was found in BDI (F = 4.54, p = 0.039) and the non-reactivity subscale psychotherapy for neurotic and
of FFMQ (F = 7.05, p = 0.011) at 8 weeks, which indicated specifi- personality disorders
cally that s-MBCT improved depressive symptoms and the facet of M. Mielimaka1* , K. Rutkowski1 , J. Sobanski1 , E. Dembinska1 , K.
non-reactive attitudes in mindfulness. Cyranka2 , A. Citkowska-Kisielewska1 , M. Zalewska1
1 Jagiellonian University Medical College, Department of
Conclusions.– The present findings provide preliminary evidence
that a shortened MBCT program may bring meaningful benefits to Psychotherapy, Krakow, Poland; 2 Jagiellonian University Medical
patients in active depression. With its briefer practices and reduced College, Department of Psychiatry, Krakow, Poland
cognitive demands, s-MBCT may serve as an accessible option for
people with more debilitating depressive symptoms.
Background and aims.– Symptoms of neurotic and personality dis-
orders often disturb patients functioning in social context. In this
interest statement.
research emphasis is given to identification and detailed analysis
of coping mechanisms, styles and strategies of patients diagnosed
with neurotic disorders and selected personality disorders (ICD-10:
F4X.X, F60.X, F61). Disturbances in reaction to difficult, stressful sit-
uations have been indicated as a potential, important contributing
factor in the long therm course of neurotic and personality disor-
ders.
Methods.– 50 patients qualified for treatment with intensive,
short-term, predominantly psychodynamic psychotherapy were
examined at the beginning of treatment with selected measures E-PP0971

identifying and exploring coping mechanisms and strategies: Brief- Changes in resting-state functional
COPE, Coping Inventory for Stressful Situations (CISS) and General
connectivity after intensive somatic
Self Efficacy Scale (GSES). Results have been analyzed with refer-
ence to data acquired from general population and with adequate
group psychotherapy- preliminary
statistical methods. report
Results.– At the beginning of treatment patients diagnosed with T. Pawlowski1* , P. Podgórski2 , M. Wolanczyk2 , M. Randolf3,4 , J.
neurotic and selected personality disorders differ significantly Klosowska-Belda3 , A. Koltowska2
1 Wroclaw Medical University, Division of Psychotherapy and
from the general population regarding coping responses and self-
efficacy. Humor, active coping, planning and positive reframing Psychosomatic Medicine Department of Psychiatry, Wroclaw, Poland;
2 Wroclaw Medical University, Department of Radiology, Wroclaw,
were among responses less frequently observed in patients. Self-
blame, venting, denial were more commonly identified. Moreover, Poland; 3 Laboratory of Psychoeducation, Laboratory of
patients have less frequently applied task-oriented coping and Psychoeducation, Warsaw, Poland; 4 Radix, Radix, London, United
more frequently emotion-oriented coping. Kingdom
Conclusions.– Patients suffering from neurotic and personality dis-
orders react to every-day life stressors more frequently utilizing
Background and aims.– Mechanisms through which psychother-
ineffective and counterproductive strategies that often lead to
apy enhances functioning remain difficult to specify. Resting-state
intensification of distress, hindrance of the process of problem reso-
functional magnetic resonance imaging provides a noninvasive
lution and interpersonal difficulties. The consequences of identified
method to map functional communication in the brain network
disturbances in coping with difficult, stressful situations may fur-
and gives possibility to find the associations between response to
ther increase the intensity of symptoms of neurotic and personality
psychotherapy and baseline activity in several key regions.
disorders constituting a vicious circle.
The aim of the present study was to investigate changes in resting-
state functional connectivity in a sample of adolescents with
interest statement.
diagnosis of anxiety disorders after 5 days intensive somatic group
psychotherapy.
E-PP0970 Methods.– Resting-state fMRI data was obtained from 7 volunteers
two times: one week before and one week after psychotherapy.
Assessment of the psychosocial MR scans were performed using Philips Ingenia 3T scanner and
adjustment in patients with brain 32-channel ds-head with closed eyes using EPI-BOLD sequences at
contusion 2.5 mm isotropic resolution at an acquisition time of 15 minutes.
S. Moroz1* , S. Ryzhenko1 , B. Mykhailov2 , R. Khaitov1 The structural data were collected in an isotropic resolution of
1 CI “Dnipropetrovsk Region Clinical Hospital Named after I.I. 0.75 mm in the T13D TFE sequence. The CONN software (web.conn-
Mechnikov”, Psychoneurology Department, Dnipro, Ukraine; 2 toolbox.org) was used to process the obtained functional data along
Kharkiv Medicine Academy of Postgraduate Education, with structural data. We used the functional connectivity method
Psychotherapy, Kharkiv, Ukraine based on regions of interest (ROI-ROI).
Results.– We found increased connectivity in a sub-network of con-
nections encompassing the anterior cerebellar network with right
Background and aims.– Brain contusion is a disabling mental dis- nucleus accumbens and posterior cerebellar network with right
order associated with reduced quality of life, impaired functioning anterior insula (p-FDR < 0.01). The above changes were found in
and significant burden for families and society. To assess the psy- all subjects but due to the current size of the group are preliminary
chosocial adjustment in patients with brain contusion, and to and require further confirmation.
identify the social and clinical features interfering with this adjust- Conclusions.– The changes in sub-network comprise areas mainly
ment. involved in interoceptive information and in emotional processes
Methods.– This is a cross-sectional, descriptive and analytic study induced by somatic group psychotherapy demonstrate that this
involving 78 patients diagnosed with brain contusion. Psychosocial method of psychotherapy takes effect through a “bottom-up”
adjustment was assessed with The Social Function Scale (SFS). The mechanism.
leading role was played by a combination of two areas of work: Disclosure of interest.– The authors have not supplied a conflict of
psychotherapy (individual and family) and psychosocial work. interest statement.
Results.– Identified risk factors for social functions: 14.1% of patients
were unemployed, 48,7% of employed subjects had significant
occupation impairment. 37,2% were divorced or separated. 10,3% E-PP0972
were married. 52,5% of married patients had moderate or severe
Psychiatry as psychotherapy: more
marital dysfunction, significantly influenced by having children, a
poor insight or comorbid personality, mental and behavioral disor- than 40 years of research
ders. More than a half had a moderate or severe social impairment, R. Pompei1* , A. Giampà2
1 ASL RM2, DSM, Rome, Italy; 2 Asl RM4, Ser.T, Rome, Italy
significantly influenced by mental and addiction disorder and avail- * Corresponding author.
ability of therapy. 62,8% of brain contusion patients had moderate
or severe general psychosocial maladjustment and was associated Background and aims.– In 2017, for the first time in Italy, the Min-
with psychiatric comorbid disoders, especially depressive episodes. istry of Public Health recognized psychotherapy as an essential
In 58.0% of patients showed stabilization of mental and emotional treatment for the cure of mental illness. In Italy, since 1971 the psy-
state, decrease professional maladjustment and family dysfunction chiatrist Massimo Fagioli has developed a theoretical model, known
after psychotherapy. as Human Birth Theory in which Psychiatry was essentially con-
Conclusions.– Our study underlines the importance of both pharma- ceptualized as Psychotherapy, overcoming the traditional division
cological and psychotherapeutic interventions aiming to improve between body and mind, opposing biological psychiatry and at the
psychosocial adjustment and occupational functioning in patients same time clinical psychology conceptualized as mere assistance.
suffering from brain contusion. In 1976 Massimo Fagioli started an original experience of group
Disclosure of interest.– The authors have not supplied a conflict of psychotherapy called Analisi Collettiva, conducted until 2017, the
interest statement. year of his death. Analisi Collettiva was gradually structured with
four psychotherapy sessions per week, and each session lasted E-PP0974
4 hours. Brief psychotherapeutic
In these large groups of psychotherapy thousands of people found a psychodynamic intervention in a
cure for mental illness developing at the same time research about
human relationships, important to form personal identity.
primary care university setting
In this paper we propose our clinical experience with two groups of K. Tzartzas1* , G. Ambresin2
1 University of Lausanne, Department of Ambulatory Care and
psychotherapy constituted of young adults, which are conducted in
a Public Health Center, with a psychodynamic psychotherapy based Community Medicine, Lausanne, Switzerland; 2 University of
on Massimo Fagioli’s Human Birth Theory. Lausanne, Department of Psychiatry, University Institute of
Methods.– The interpretation of the annulment pulsion theorized by Psychotherapy IUP, Lausanne, Switzerland
Fagioli in 1971 is the specific instrument of cure that we use to
interpret patients’ pathological behaviour, their conscious mental Background and aims.– General practitioners (GPs) mostly use med-
activity and their non- conscious mental activity which expresses ication as a first line treatment of mental health problems (MHP),
itself through dreams. whereas psychiatrists use psychotherapeutic treatments, who have
Results.– A positive quality reaction is expressed through the demonstrated their effectiveness. We present an intervention aim-
change in oneiric activity and symptomatology. ing to propose a psychotherapeutic consultation in a primary care
Conclusions.– These results encourage further studies about the setting (PCS). We investigated the feasibility of brief psychody-
possibility to apply psychotherapy based on HBT in Public Health namic intervention (BPI) in PCS.
Center. Methods.– Consultation-liaison (CL) psychiatrists conducted a
Disclosure of interest.– The authors have not supplied a conflict of “three step” BPI in a university outpatient PCS (Figure 1).
interest statement.
E-PP0973
Community-based multi-site
randomized controlled trial of
behavioral activation for negative
symptoms of individuals with chronic
schizophrenia
H.J. Seo1* , E. Lee2 , K.H. Choi2
1 Catholic University of Korea, Psychiatry, Suwon-si, Republic of
Korea; 2 Korea University, Psychology, Seoul, Republic of Korea
Background and aims.– The primary purpose of the current study

was to investigate whether BA would improve negative symp-
toms as compared with treatment as usual (TAU) for community
dwelling individuals with chronic schizophrenia.
Methods.– Community mental health professionals were trained
with BA manual for negative symptoms of schizophrenia and their
treatment fidelity was checked by the authors. BA was delivered
in a group format once a week for 10 weeks. Seventy-two patients Figure 1. Brief psychotherapeutic intervention in primary care.
with negative symptoms of schizophrenia were randomly assigned Interventions were adapted to the patients “regression” levels and
into either the BA + TAU (n = 38) or TAU only group (n = 34) Nega- to their defense mechanisms to take into account the heterogene-
tive symptoms and other psychiatric symptoms, quality of life, and ity of clinical presentations in PCS. GPs referred their patients to
neuro-cognitive assessment were measured at baseline, end of the the CL psychiatrist either when they detected a MHP or when they
10-week intervention, and 6-month follow-up (FU). were confronted with relationship difficulties. Cooperative work
Results.– BA was well accepted by community dwelling individuals was held, with the agreement of the patient. An observational study
with chronic schizophrenia (drop-out rates of BA + TAU and TAU, was conducted during a year in a university outpatient PCS.
13% and 20%, respectively). Intention-to-treat analyses indicated Results.– 64 patients were seen by the psychiatrist. Fifty-one (80%)
that compared to TAU condition, BA + TAU group was associated of them received a BPI. Various mental disorders were treated
with large improvement at post-treatment in negative symptoms (mood, neurotic, somatoform, personality disorders etc.). A new
(Fig. 2). However, the significant treatment benefits were not main- psychotropic prescription was needed in 17 interventions (27%).
tained at the 6-month follow-up. Effect sizes ranged from medium Feedback from GPs indicated that their expectations were satisfied
to large at post-treatment, and small to medium at FU (Table 1). by the proposed intervention.
There were no differences between the group on measures of other Conclusions.– By the BPI a “multilevel” balance is found between:
psychiatric symptoms, quality of life and neurocognitive function- (a) a psychotherapeutic intervention for the patient, (b) his internal
ing. and external reality and (c) an exposition of the psychotherapeutic
Conclusions.– The results demonstrate the feasibility and the reasoning to GPs.
efficacy of BA when delivered by re-trained mental health profes- Disclosure of interest.– The authors have not supplied a conflict of
sionals with a structured BA manual at community mental health interest statement.
centers. Further investigations are needed to replicate the current
findings in RCT with a larger sample.
interest statement.
E-PP0975 Methods.– A baseline data collection was done and a doctor’s ques-
What people think works in tionnaire on their experience using the existing physical health
psychotherapy: a qualitative and proforma document. Using this feedback a new document was cre-
ated and PDSA (plan do study act) cycles done with adjustments to
quantitative assessment of process the document until >90% compliance was achieved.
expectations Results.– Baseline compliance was 75%, improving to 80% after cycle
D. Tzur Bitan1,2* , A. Lazar2 1 and 90% after cycle 2. Post-measurement compliance was 90%
1 Shalvata Mental Health Center, Psychiatric ER, Hod Hasharon, with the use of the new document.
Israel; 2 Ariel University, Department of Behavioral Sciences, Ariel, Conclusions.– Traditional audits have notoriously failed to sustain
Israel improvement in the trust but by using a quality improvement
approach we have been able to achieve a successful and effective
way of bettering patient care with the hope of having a lasting
Background and aims.– Although the effectiveness of psychother-
positive impact on their physical health.
apy is well-established, the debate regarding the active processes
which produce a therapeutic change is still ongoing. An important
interest statement.
question stemming from this debate is whether lay individuals
might not themselves have a clear view regarding what works
in a therapeutic process. In this study we aimed to address this E-PP0977
question by investigating individuals’ expectations of the active
processes described in the current literature as important facilita-
Integrative care and quality of life
tors of change, using both qualitative and quantitative approaches. (QOL) promotion through icts in
Methods.– Participants (n = 174) were requested to describe in writ- persons with spinal cord injury (SCI):
ing what they viewed as the active processes which produce a a pilot study
therapeutic change in psychotherapy, and to rank seven active pro- E. Gkintoni* , A. Tzanos, A. Kyriakidis, E. Panagiotopoulos
cesses according to their perceived potency in producing change. University of Patras, Spinal Cord Injuries Rehabilitation Department,
Results.– The results of the qualitative analysis indicated that emo- Rio- Patras, Greece
tional and verbal expression was the most frequently identified * Corresponding author.
theme. Quantitative analysis showed that participants ranked the
ability to share sensitive contents openly and securely as the high- Background and aims.– Introduction:SCI is a complex phenomenon
est active process. leading to bio-psychosocial changes which affect patients’ as well
Conclusions.– The findings of the current research indicate that indi- as their caregivers’ health and QoL. Information and Communica-
viduals view psychotherapy as potent primarily due to its allowing tion Technologies (ICT) is expanding in the health field, providing
them to talk, while attributing less weight to more established health care services, disseminating technical-scientific knowledge,
active processes such as the therapeutic relations. Implications and sharing popular knowledge, and overcoming geographic distances,
directions for future research are discussed. and temporal and sociocultural barriers. The relevant field for this
Disclosure of interest.– The authors have not supplied a conflict of is called Telemedicine or Telehealth, with interactions mediated
interest statement. in real time or not, through the internet or global social networks
technologies, with the use of application software or not.
Objectives.– To address in a better manner the special needs of
community individuals with SCI and to investigate the possible
E-Poster Presentation: Quality promotion of their QoL using ICT.
Management/Psychopathology Methods.– We established a useful set of ICT tools (live chatbox, call
to action, interactive videos, social networks, etc) so as to enhance
peer-support between individuals with SCI or direct contact with
E-PP0976 health professionals through Redline (physician, nurse, psychol-
ogist), to present e-learning modules upon psychoeducation and
Improving physical health care to demostrate exercise-physio programs through videos. The pos-
provided to adult psychiatric sible improvement in participant’s QoL will be measured by the
inpatients at coventry and World Health Organization Quality of Life BREF (WHOQOL-BREF)
warwickshire partnership trust questionnaire.
S. Byravan* , S. Hassan, K. James Results.– We expect that the appropriate use of internet and
Coventry and Warwickshire Partnership Trust, Psychiatry, Coventry, Telemedicine will favor the QoL of individuals with SCI as they
United Kingdom provide long-distance delivery of medical education and services
* Corresponding author. reducing reliance on in-patient care.
Conclusions.– Conclusions:Health professionals and institutions,
Background and aims.– It is well known that psychiatric patients are that are involved in care of individuals with SCI, should be pre-
at particular risk of developing physical health complications when pared to redefine their care practices and adopt new perspectives
compared to non-psychiatric patients. Mental illness has a nega- on Telerehabilitation in favor of service quality, as well as patients’
tive relationship with physical health especially in those those with satisfaction and wellbeing.
severe mental illnesses. This is reflected in the 12.9-year reduction Disclosure of interest.– The authors have not supplied a conflict of
in life expectancy for males and 11.8-year reduction in females with interest statement.
a serious mental illness compared with the general UK population.
The reasons for this are multifactorial; lifestyle, diet, risk taking
behaviours and psychotropic medications all being contributors.
When patients are admitted it is a prime opportunity for doctors
to review patients’ physical health, it is a chance to implement
primary and secondary health interventions.
Aim.– To improve compliance with the medical physical health
checks by doctors for psychiatric inpatients on admission.
E-PP0978 disorders (’comorbid’, N = 222), remitted participants (N = 1107),

Acute inpatient mental health staff’s and healthy control participants (N = 470).
views on factors affecting their Results.– Participants were on average 46.2 years old (SD = 13.1),
and 66.3% were female. Trait anger and anger attacks were most
morale: a qualitative survey prevalent in participants with comorbid depressive and anxiety
N. Lekka* , R. Humphries, R. Talukdar
disorders (M = 18.51 and 22.1%, respectively), followed by anxi-
Sheffield Health and Social Care Foundation Trust, Acute Inpatient
ety disorder, depressive disorder, remitted disorder, and controls
Services, Sheffield, United Kingdom
(M = 12.70 and 1.3%, respectively), in that order (p < 0.001). MDD,
social phobia, panic disorder, and GAD had the strongest link to
Background and aims.– Staff morale may be influenced by job char- both trait anger and anger attacks. Being male, having fewer years
acteristics and organisational factors. Acute mental health wards of education, and alcohol dependency/abuse were independently
are stressful work environments, where increased numbers of associated with trait anger. Age was inversely associated with anger
detained patients, high levels of verbal/physical violence, high staff attacks.
sickness and burnout rates, difficulties with staff recruitment and Conclusions.– Anger is most prevalent in patients with comorbid
retention, and pressure for short lengths of patient stay are com- depressive and anxiety disorders. Participants with a remitted dis-
mon. This study aimed to explore factors that demoralised inpatient order were still at a higher risk of trait anger and anger attacks as
mental health staff. compared to controls.
Methods.– An online survey with free text was sent to all 193 multi- Disclosure of interest.– The authors have not supplied a conflict of
disciplinary staff members of three general adult acute wards, one interest statement.
psychiatric intensive care unit and one older adults acute ward. A
qualitative approach was used to explore potential causes of staff
E-PP0980
demoralisation and to gain deeper understanding of participants’
perspectives. Manual thematic analysis was completed to identify Validation of the Jasper/Goldberg
discrete themes. adult ADD screening examination -
Results.– Response rate was 58%, with 112 professionals respond- version 5.0 in a sample of the
ing, including 59 nurses, 28 support workers, 11 doctors, 4 Portuguese population
pharmacists and 10 other. Staff felt demoralised by their experi- H. Espírito-Santo* , C. Duarte, C. Madeira-Sério, L. Lemos
ences with senior management (30%), low staffing levels (25%), bed Instituto Superior Miguel Torga, Psychology, Coimbra, Portugal
pressures (21%), high workload and long hours (9%), organisational * Corresponding author.
systems and processes (8%), verbal/physical abuse in the workplace
(8%) and other factors (29%) including lack of support, “not being Background and aims.– Attention Deficit/Hyperactivity Disorder
listened to”, non-effective communication about changes, and lack is a common disorder diagnosed in the childhood (9 to 20%).
of time to spend with patients. Although 50–70% of children with Attention Deficit/Hyperactivity
Conclusions.– Participants emphasised the negative effect of Disorder continue to display symptoms in adulthood, preva-
inadequate staffing, bed pressures, high workload, inefficient lence rates in adults are estimated at around 4%. Adult Attention
organisational systems, perceived poor communication and sup- Deficit/Hyperactivity Disorder is an important disorder as 88%
port from senior management, and feeling unsafe in a violent of diagnosed adults are known to show other mental health
environment on their morale. Safe, better-resourced ward envi- problems. Since adult Attention Deficit/Hyperactivity Disorder
ronments and well-structured organisational procedures may may be undiagnosed, it is essential to use psychometric robust
contribute to improved staff morale. Attention-Deficit/Hyperactivity Disorder-specific instruments for
Disclosure of interest.– The authors have not supplied a conflict of its screening. This study aimed to validate the Jasper/Goldberg
interest statement. Adult ADD Screening Examination - Version 5.0 in a sample of the
Portuguese population.
Methods.– 404 members of the general population filled a
E-PP0979 sociodemographic-clinical questionnaire and the 24 items Adult
Trait anger and anger attacks in ADD Screening Examination-5 in an internet survey displayed in a
patients with depressive and anxiety self-help web page about adult Attention Deficit/Hyperactivity Dis-
order. The mean age was 32.54 years (SD = 9.95) ranging between
disorders
18 and 71; 60.5% were women, and the mean education was 15.58
N. De Bles1* , N. Rius Ottenheim1 , A.M. van Hemert1 , L.E.H. Pütz1 ,
years (SD = 4.39).
A.J.W. van der Does2 , B.W.J.H. Penninx3 , E.J. Giltay1
1 LUMC, Department of Psychiatry, Leiden, The Netherlands; 2 Leiden Results.– Cronbach’s alpha was 0.92 with a four-factor structure
explaining 57.0% of the variance (Kaiser-Meyer-Olkin measure of
University, Faculty of Social Sciences, Leiden, The Netherlands; 3
sampling adequacy = 0.91; Bartlett’s test of Sphericity: p < .001).
Amsterdam Public Health research institute- Amsterdam UMC, Vrije
Conclusions.– The preliminary results indicate that the
Universiteit, Department of Psychiatry, Amsterdam, The Netherlands
* Corresponding author. Jasper/Goldberg Adult ADD Screening Examination-5 is a valid
instrument for the general adult population. Future directions
Background and aims.– High levels of anger may occur in patients include establishing the validity for the screening of Attention
with various psychiatric disorders, and this is associated with mal- Deficit/Hyperactivity Disorder with clinical samples.
adaptive (e.g., aggressive) behaviours. We aimed to investigate the Disclosure of interest.– The authors have not supplied a conflict of
level of trait anger and the prevalence of anger attacks in patients interest statement.
with depressive and anxiety disorders, as well as their sociodemo-
graphic and clinical associations.
Methods.– In the Netherlands Study of Depression and Anxiety
(NESDA) cohort study, the anger trait was assessed with the
Spielberger State-Trait Anger Scale and anger attacks with the
Anger Attacks Questionnaire. We included patients with depres-
sion (N = 204), anxiety (N = 288), comorbid depressive and anxiety
E-PP0981 being without a mobile phone, a smartphone or Internet, induc-

Depression and anxiety in ICU ing a negative impact in the individual’s life. In order to assess this
survivors: association with length of construct, the Nomophobia Questionnaire (NMP-Q) was developed
and proved to be a valid and reliable measure. This study aimed
stay to develop the Portuguese version of the Nomophobia Question-
S. Martins1,2 , I. Coimbra3 , L. Fontes3 , L. Lopes3 , J.A. Paiva3,4 , L.
naire (NMP-Q-PT) and explore its factor structure and psychometric
Fernandes1,2,5*
1 Cintesis, Center for Health Technology and Services Research, Porto,
characteristics in the general population.
Methods.– A sample of 203 participants was recruited at a university
Portugal; 2 Department of Clinical Neurosciences and Mental Health,
and online. Participants completed a sociodemographic question-
Faculty of Medicine- University of Porto, Porto, Portugal; 3 Intensive
naire, the NMP-Q-PT, the Smartphone Admission Scale - Short
Care Medicine Department, Centro Hospitalar São João CHSJ, Porto,
Version (SAS-SV) and the Depression, Anxiety, and Stress Scales
Portugal; 4 Department of Medicine, Faculty of Medicine- University
(DASS-21). College students completed the instruments in a paper
of Porto, Porto, Portugal; 5 Clinic of Psychiatry and Mental Health,
pencil format and participants recruited online also completed the
Centro Hospitalar São João CHSJ, Porto, Portugal
instruments online.
Results.– According to the original version a 4-factor model was
Background and aims.– Critical illness survivors frequently face tested. Results suggested that defining correlations between items
complex physical, cognitive and psychological sequelae. Among 5 and 6, 17 and 20, 11 and 14 would improve the fit. This sec-
psychological consequences, depression and anxiety are frequent ond model was tested and fit indexes were: 2 /gl = 2.26; CFI = .945;
and can have a negative impact on survivors’ recovery and quality GFI = .849; RMSEA = .079; MECVI = 2.347. A Cronbach’s alpha of .96
of life. was found. Regarding correlations between the NMPQ-PT and the
Aims.– To describe depression and anxiety in survivors at 3-months SAS-SV, results showed a positive correlation. Positive correlations
of Intensive Care Unit/ICU discharge and to examine their associa- were also found between NMP-Q-PT and depressive symptoms,
tion with Length of Stay/LOS. anxiety symptoms and stress symptoms of DASS-21.
Methods.– Prospective study with adult outpatients of follow-up Conclusions.– The current study allowed to achieve a Portuguese
appointment of Intensive Care Medicine Service in CHSJ-Porto, who version of the NMP-Q that showed to be a valid and reliable instru-
had ICU-LOS ≥ 5 days, having sequelae/dysfunctions (due to crit- ment for the assessment of nomophobia.
ical illness/organic support at ICU discharge) and currently with Disclosure of interest.– The authors have not supplied a conflict of
autonomy to come to appointment. Brain injury at ICU admission interest statement.
and inability to communicate were exclusion criteria. Participants
were assessed with Hospital Anxiety and Depression Scale/HADS
E-PP0983
and illness severity with APACHE-II.
Results.– The sample (n = 30) had a mean of 56(±15) y.o., and were Disability in adult psychosomatic
mostly male (77%) and married (60%). The mean APACHE-II on inpatients suffering from attention
admission was 18.9 (±10). The mean ICU-LOS was 18.4(±15) days deficit hyperactivity disorder (ADHD)
and medical admission diagnostic category prevailed (46.7%) over and minimal cerebral dysfunction
surgery and trauma ones. Overall, 24% had depression and 14% anx-
iety. The main anxiety symptom reported was “feel tense/wound
(MCD)
M. Linden* , N. Nils
up” (48.3%) and “feel as if have slowed down” (41.4%) was the most
Charité University Medicine Berlin, Psychosomatic Medicine, Berlin,
frequent regarding depression. Positive correlations between ICU-
Germany
LOS and depression (rs = 0.451; p = 0.014) and anxiety (rs = 0.433; * Corresponding author.
p = 0.019) were found.
Conclusions.– These results support the hypothesis that depression Background and aims.– Attention Deficit Hyperactivity Disorder
and anxiety are frequent in ICU survivors and increasing ICU-LOS (ADHD)” often persist into adulthood. Additional to attention
was associated with more depression and anxiety at follow-up. deficits and hyperactivity, there is a broad spectrum of further
However, future studies are needed to explore other factors related minimal cerebral dysfunctions, which also can cause impairment.
to long-term psychological morbidity, to better understand these Objectives were to investigate the contribution of additive symp-
psychological consequences. toms of ADHD to disability.
Acknowledgement.– This work was supported by FCT fellowship Attention Deficit Hyperactivity Disorder (ADHD)” often persist into
(SFRH/BPD/103306/2014). adulthood. Additional to attention deficits and hyperactivity, there
Disclosure of interest.– The authors have not supplied a conflict of is a broad spectrum of further minimal cerebral dysfunctions,
interest statement. which also can cause impairment.
Objectives were to investigate the contribution of additive symp-
toms of ADHD to disability.
E-PP0982
Methods.– The ADHS-SB (attention deficit hyperactivity scale)”, the
Assessing nomophobia: the “MCD- scale (minimal cerebral dysfunction scale)”, and the “SCL-
portuguese version of the 90R (Symptom Checklist)” were answered by 1453 inpatients of a
nomophobia questionnaire psychiatric-psychosomatic hospital.
A. Galhardo1* , D. Loureiro2 , I. Massano-Cardoso3 , M. Cunha1 Results.– ADHD cases (according to the AHS-SB) show a lower voca-
1 Instituto Superior Miguel Torga and Faculty of Psychology and tional qualification, longer absenteeism and overburdening at the
Educational Sciences of the University of Coimbra, Cineicc, Coimbra, workplace, a higher unemployment rate and a higher SCL-GSI score
Portugal; 2 Instituto Superior Miguel Torga, Psychology, Coimbra, than controls. Regression analyses show that psychological dis-
Portugal; 3 Instituto Superior Miguel Torga and Faculty of Medicine of tress and ability to work are preferably influenced by problems
the University of Coimbra and Faculty of Economics of the University of orientation, cognitive impairment, vegetative lability, emotional
of Coimbra, Ceisuc, Coimbra, Portugal problems, disorders of motor function and only a lower degree by
* Corresponding author. hyperactivity.
Conclusions.– Disability of ADHD patients is depending on additive
Background and aims.– The nomophobia (no mobile phone phobia) symptoms (emotional, cognitive, motor, vegetative), rather than
may be considered a specific phobia characterized by the fear of the core symptoms hyperactivity and attention deficit.
Disclosure of interest.– The authors have not supplied a conflict of Rawalpindi and Islamabad, with age 15 to 19 years (M = 16.47,
interest statement. SD = 1.3 years). Issues Checklist (IC; Robin & Foster, 1989), Ego
Resiliency Scale Revised (ER-89 R; Alessandri, Vecchio, Steca,
Caprara, & Caprara, 2007) and Depression Anxiety and Stress Scale
E-PP0984 (DASS-21; Lovibond & Lovibond, 1995) were used to measure
Self-compassion and repetitive parent-adolescent conflict, resilience and psychological distress
negative thinking in non-clinical (depression, anxiety and stress).
Results.– Results indicated that boys were significantly higher on
paranoia: differential contributions to
conflict with their parents as compared to girls. Significant positive
depression and satisfaction with life relationship between parent-adolescent conflict and depression
M.J. Martins1 , C. Machado1 , J. Peixoto1 , S. Magano2* , M. Coroa2 , I. (r = .23, p < .01), anxiety (r = .31, p < .01) and stress (r = .33, p < .01)
Leal1 , A. Macedo1 confirmed our assumptions. Contrary to that, resilience signifi-
1 Faculty of Medicine- University of Coimbra, Institute of
cantly negatively related with depression (r = −.25, p < .01), anxiety
Psychological Medicine, Coimbra, Portugal; 2 Centro Hospitalar e (r = −.18, p < .01) and stress (r = −.26, p < .01). Results of modera-
Universitário de Coimbra, Department of Psychiatry, Coimbra, tion analyses indicated that resilience moderates the relationship
Portugal between parent-adolescent conflict and psychological distress (i.e.,
depression, anxiety and stress) among adolescents.
Background and aims.– In the rise of process-based psychotherapy, Conclusions.– It is concluded that resilient adolescents face less con-
understanding the processes underlying human suffering in clinical sequences of conflicts with parents in terms of psychopathology. It
and non-clinical populations is key. Repetitive negative think- is recommended that intervention plans shall focus resilience in
ing (RNT) and self-compassion are widely studied processes with adolescents to avoid negative consequences of parents-adolescent
strong evidence regarding their association with psychopathology conflicts.
and quality of life. To our knowledge the associations between these Disclosure of interest.– The authors have not supplied a conflict of
variables and paranoia is still not studied. interest statement.
We aimed to explore the associations between paranoia, RNT, self-
compassion components (positive and negative), depression and
E-PP0986
satisfaction with life in a non-clinical sample. Also, we sought to
understand the mediator role of self-compassion and RNT in the The obsessive-compulsive dimension
relationship between paranoia and depression or satisfaction with in acute inpatients with schizophrenia
life. spectrum disorders: the impact on
Methods.– The sample (N = 235) was mostly female (65.5%), married clinical and symptomatological profile
(23.8%), with a mean age of 29.83 and 15.79 years of education. G. Menculini1* , P.M. Balducci1 , L. Attademo2 , F. Bernardini3 , E.
Participants were assessed via self-report questionnaires. Pearson Lucarini1 , P. Moretti1 , A. Raballo1 , A. Tortorella1
correlations were examined and two parallel multiple mediations 1 University of Perugia, Department of Psychiatry, Perugia, Italy; 2
were performed. SPDC Potenza, Department of Mental Health, ASP Basilicata, Potenza,
Results.– All variables under study were significantly associated Italy; 3 CSM 24h Area delle Dolomiti Friulane - REMS, Department
with each other. Both models were significant and explained 32% Mental Health AAS5 Friuli Occidentale, Pordenone, Italy
and 10% of depression and satisfaction with life, respectively. The * Corresponding author.
direct influence of paranoid ideation was significant in both models.
The only indirect effects found were for the influence of negative Background and aims.– The presence of obsessive-compulsive
and positive components of self-compassion in depression and pos- symptoms (OCS) contributes to the complexity of schizophrenia
itive components in satisfaction with life. spectrum disorders (SCHZ), despite it is not enlisted as one of the
Conclusions.– Although in need for replication, our results indicate canonical symptom dimensions. The present study investigates the
the relevance of self-compassion in both depression and satisfac- impact of OCS on the clinical profile and the psychopathology of
tion with life. These results can inform future research on paranoia SCHZ in a sample of acute inpatients.
and potentially provide targets for prevention programs. Methods.– Patients were recruited at the Psychiatric Inpatient Unit
Disclosure of interest.– The authors have not supplied a conflict of in the General Hospital of Perugia, Umbria, Italy, from January
interest statement. 2015 to March 2017. Socio-demographic and clinical information
were collected. Psychopathological assessment was performed by
means of the Positive and Negative Syndrome Scale (PANSS) and
E-PP0985 the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The PANSS
Moderating role of resilience in autism severity score (PAUSS) and the positive, negative, disorga-
relationship between nization, excitement and emotional distress factors of the PANSS
were analysed according to a dimensional approach. The whole
parent-adolescent conflict and
sample (n = 97) was divided into three groups according to Y-BOCS
psychological distress among scores (absent OCS: 0-7; mild: 8–16; moderate/severe: >17) and
adolescents compared using chi square test and ANOVA.
J.A. Malik* , S. Shahnawaz Results.– The three groups did not differ in terms of socio-
Quaid-i-Azam University, National Institute of Psychology, demographic and clinical characteristics. As for psychopathology,
Islamabad, Pakistan SCHZ patients with severe OCS (n = 39) presented higher scores at
the negative (p = 0.007), emotional distress (p = 0.006) and PAUSS
(p = 0.005) factors than patients with absent OCS (n = 39).
Background and aims.– The research was aimed to explore the
Conclusions.– The presence of severe, but not mild, OCS defines
relationship between parent-adolescent conflict, resilience and
a worse clinical frame for a subgroup of SCHZ acute inpatients,
psychological distress among adolescents. It was hypothesized that
deserving an adequate identification and targeted intervention
parent-adolescent conflict increases psychological distress among
strategies.
adolescents and that resilience moderates this relationship.
Methods.– Sample of the study comprised of N = 459 adoles-
interest statement.
cents from different educational institutions in the premises of
E-PP0987 Objectives.– To explore whether parents with clinically significant

Verbal auditory hallucinations as a levels of anxiety/depression symptoms experience more parenting
speech disorder: recent evidence, stress and have lower levels of mindful parenting; and to explore
whether anxiety/depression symptoms contribute to lower levels
long-standing psychoanalytical of mindful parenting through higher levels of parenting stress.
insights and the need for unified Methods.– A sample of 1082 Portuguese mothers (Mage = 41.39
theoretical frameworks of psychotic years, SD = 5.75, range = 24–62) of children/adolescents (aged
phenomena between 8 and 19 years) from the general community, completed
G. Mitropoulos1* , D. Gorgoli2 the Hospital Anxiety and Depression Scale, the Parenting Stress
1 Psychiatric Hospital of Attica, 5th Department, Athens, Greece; 2 Scale, and the Interpersonal Mindfulness in Parenting Scale. Dif-
Constantopouleio General Hospital of Nea Ionia, Psychiatric ferences in parenting stress and mindful parenting as a function
Department, Athens, Greece of anxiety/depression symptoms were analyzed through ANOVAs.
* Corresponding author. The indirect effects of depression and anxiety on mindful parenting
through parenting stress were explored through mediation analy-
Background and aims.– Verbal auditory hallucinations (VAH) ses.
are hallmark symptoms of psychosis, and more specifically of Results.– 20.1% of parents reported clinically significant levels
schizophrenia. A huge body of evidence indicates that VAH’s can of anxiety and/or depression symptoms. This group of parents
been attributed to a disorganization of overall speech capacity in reported significantly higher levels of parenting stress and lower
psychotic subjects. levels of mindful parenting. Parenting stress mediated the associa-
Methods.– Firstly, during VAHs mainly brain areas responsible for tion between maternal anxiety/depression and mindful parenting.
speech generation and understanding are activated; [1] secondly, Conclusions.– Maternal psychopathology increases the likelihood of
psychotic patients’ own subvocal speech has virtually the same parenting stress, thereby contributing to lower levels of a mindful
content as VAHs; thirdly, according to cognitive models, AVHs approach in parenting. Interventions to decrease maternal psy-
result from the misattribution of inner speech (that is, the patient’s chopathology and parenting stress are much needed.
own thoughts) to external sources [2]. Disclosure of interest.– The authors have not supplied a conflict of
Results.– The above evidence seems to confirm some of the interest statement.
long-standing insights mainly of the French psychiatric (de Cleram-
beault) and psychoanalytical (Lacan) school, according to which a)
the outside world is perceived through normal language function E-PP0989
b) a language disorder is central to all psychotic phenomena and The Italian version of the brief 21-item
c) VAHs represent an autonomization of speech (thought) func- prodromal questionnaire (IPQ-B)
tion in comparison to subjective sense of self (de Clerambeault: L. Pelizza1* , S. Azzali1 , F. Paterlini1 , S. Garlassi1 , I. Scazza1 , M.
“hallucinations think”) [3]. Poletti1 , L.R. Chiri2 , E. Semrov1 , A. Raballo3
Conclusions.– We conclude with stressing the need for a) a shift 1 Reggio Emilia Public Health-Care Centre, Reggio Emilia Department
towards a more theoretically informed understanding of psychotic of Mental Health and Pathological Addiction, Reggio Emilia, Italy; 2
phenomena and b) to the integration of different levels of explana- Bologna Public Health-Care Centre, Bologna Department of Mental
tion/different branches of enquiry of mental phenomena [4]. Health and Pathological Addiction, Bologna, Italy; 3 University of
[1] Zmigrod et al. (2016). Neuroscience & Biobehavioral Reviews, 69, Perugia, Division of Psychiatry, Clinical Psychology and
113–123. Rehabilitation- Department of Medicine, Perugia, Italy
[2] Moseley, Fernyhough & Ellison (2013). Neuroscience & Biobehav- * Corresponding author.
ioral Reviews, 37(10), 2794–2805.
[3] Lacan (1981). Le Seminaire, livre III, Les psychoses (1955–1956), Background and aims.– The (21-item) Brief version of the Prodromal
Texte établi par Jacques-Alain Miller, Paris, Seuil. Questionnaire (PQ-B) is a promising screening test for psychosis-
[4] Hugdahl & Sommer (2017). Schizophrenia bulletin, 44(2), risk states that could be implemented in routine clinical practice.
234–241. We herewith evaluated psychometric properties of the Italian ver-
Disclosure of interest.– The authors have not supplied a conflict of sion of the PQ-B (iPQ-B) in a sample of 243 adolescent and young
interest statement. adult help-seekers (aged 13–35 years).
Methods.– After completing the iPQ-B, participants were assessed
with the Comprehensive Assessment of At-Risk Mental States
E-PP0988 (CAARMS). Diagnostic accuracy (sensitivity, specificity, positive
The role of maternal psychopathology and negative predictive values [PPV and NPV], positive and nega-
on parenting stress and mindful tive likelihood ratios) and concurrent validity between PQ-B and
CAARMS were determined using Cronbach’s alpha and Cohen’s
parenting
kappa. We also tested the validity of the adopted PQ-B cut-offs
H. Moreira1* , M.C. Canavarro2 , M.J. Gouveia3
1 through Receiver Operating Characteristic (ROC) curves plotted
University of Coimbra, Center for Research in Neuropsychology and
against CAARMS diagnoses and the predictive validity of the iPQ-B
Cognitive-Behavioral Intervention, Coimbra, Portugal; 2 Center for
at 1-year follow-up.
Research in Neuropsychology and Cognitive-Behavioral Intervention,
Results.– The iPQ-B had high internal consistency (Cronbach’s
Coimbra, Portugal; 3 Coimbra, Portugal
* Corresponding author. alpha = 0.868), acceptable diagnostic accuracy and concurrent
validity (70% sensitivity, 67% specificity, 81% PPV, Cohen’s
Background and aims.– It is well documented that parental psy- kappa = 0.335). ROC analyses pointed to threshold of ≥ 20 on the
chopathology is strongly associated with more negative parenting PQ-B total distress score as best cut-off. After 12 months of follow-
behaviors (e.g., hostility, intrusiveness, less affectionate contact). up, 11% of participants who scored ≥ 4 on the PQ-B distressing item
Therefore, anxious/depressed parents may struggle to engage in total score and did not meet CAARMS psychosis criteria at baseline,
a mindful parenting style, which characterized by nonjudgmen- developed a psychotic disorder. Interestingly, age had significant
tal and present-centered awareness in parent-child interactions. negative correlations with iPQ-B scores and adolescents showed
However, the mechanisms that may explain why this relationship higher iPQ-B scores than young adults.
occurs are not well understood. Conclusions.– The psychometric properties of the iPQ-B were sat-
isfactory. As iPQ-B scores appeared inversely associated to age,
age-tailored cut-off scores are recommended for screening pur- the participants from 16 to 50 years with a mean age (M = 24.91,
poses in child-adolescent cohorts. SD = 7.42) and taking antiepileptics from more than one year at
Disclosure of interest.– The authors have not supplied a conflict of least with no previous history of psychopathology or substance
interest statement. abuse. Moreover, the verbal consent was secured, and confiden-
tiality assured to the participants of the study. A brief history
(Semi-Structured Interview) was taken from the PWE about the his-
E-PP0990 tory of seizure and other demographic variables. After socializing
Do deaf psychotic patients hear to the purpose of the study, Schema Mode Inventory and Symptom
voices? - an update on the psychotic Checklist-90 administered.
Results.– Results indicated that dysfunctional coping modes, child
experience in deaf patients
modes, and maladaptive parent domains positively correlated with
J. Rema* , T. Cavaco, J. Jerónimo, C. Rodrigues, E. Reis, R. Santos
somatization, interpersonal, obsession, depression, paranoid, hos-
Psychiatry and Mental Health Resident at Hospital de Santa Maria,
tility, phobia, anxiety, psychoticism, and global severity index.
CHLN - Psychiatry and Mental Health, Lisbon, Portugal
* Corresponding author. While adaptive modes negatively correlated with the psychiatric
symptoms. Moreover, the role of socioeconomic status also exam-
Background and aims.– Deliberation on how deaf patients might ined in psychiatric symptoms and dysfunctional schema modes.
experience auditory hallucinations remains a topic of interest Conclusions.– The present study highlights that the people with
for psychopathological exploration. Deaf patients often report epilepsy need not only medical treatment but also required psy-
“conversations”, “loud voices” and other subjective narratives to chotherapeutic management.
describe important fonts of information during psychotic out- Disclosure of interest.– The authors have not supplied a conflict of
breaks. interest statement.
Objectives.– The aim is to clarify the territory of auditory hallucina-
tions in deaf patients from a phenomenological frame set.
Methods.– A literature review was conducted using the PubMed and E-PP0992
the ResearchGate search databases. The association of some
Results.– Deaf patients often experience language disfluency, bor- socioeconomic indicators with
rowing expressions from the “hearing culture” that compromise emotional and behavioral problems in
the examination. Despite the contradicting information, the state
4–5-year-old Kosovar children rated
of the art literature supports the hypothesis that pre-linguistic deaf
psychotic patients do not experience true auditory hallucinations. by parents with the child behavior
The remainder deaf psychotic patients might experience audi- checklist (CBCL 1.5–5)
tory hallucinations correlated directly to the array of experiences M. Shala
concerning language and the level of hearing loss. The psychotic University of Mitrovica ‘Isa Boletini’, Education, Mitrovice, Kosovo
experiences lived by this patients are vast and not fully grasped,
sometimes assuming the form of a delusion of hearing.
Conclusions.– To assess for auditory hallucinations in deaf patients Background and aims.– Childhood emotional and behavior prob-
an understanding of the deaf culture should be intertwined with lems represent an important topic in developmental psychopathol-
a broaden concept of a psychotic experience in this population. ogy and the preschool children have long been a neglected
Expert assessment and deaf-oriented mental status exam are population in the study of psychopathology
strongly advised. The further knowledge necessary to enlighten the Aim.– To describe the extent to which parents reported child emo-
deaf internal psychotic experiences entails bigger sampled studies, tional and behavioral problems vary by different indicators of
functional MRI studying and a re-evaluation of the concept of audi- socioeconomic status.
tory hallucination in pre-linguistic deaf patients. Clinicians should Methods.– The sample consisted of 607 children of 4–5 years old
adopt a mutational attitude in the continuing debate between (M = 4.40 years, SD = .49). Parent completed the Child Behavior
professionals’ expectations, the deaf phenomenological frames of Checklist (1.5–5), and reported the socioeconomic indicators of
reference for a psychotic experience and the unknowable. income, education, and employment. Logistic regression models
Disclosure of interest.– The authors have not supplied a conflict of were used to predict internalizing, externalizing and total scores,
interest statement. as reported by parents, and considered all putative socioeconomic
status (SES) predictor variables simultaneously.
Results.– The prevalence of parent-reported scores was 1.6% for 4-
E-PP0991 year-olds and 3.8% for 5-year-olds. Sex differences were observed,
with boys showing higher scores in externalizing and total scores.
The prediction of psychiatric features
The proportions of children scoring in the clinical range varied
from dysfunctional schema modes in according to SES indicator. All the SES indicators independently
people with epilepsy (PWE) predicted parent-reported child emotional and behavioral prob-
N. Shafique1* , M.T. Khalily2 lems, although odds ratios were generally small to moderate (1.3
1 Foundation University Islamabad, Psychology, Islamabad, Pakistan; to 2.6), and not all reached statistical significance. Low income and
2 International Islamic University Islamabad, Psychology, Islamabad,
unemployment showed larger associations than parent education.
Pakistan Conclusions.– A significant need for early identification of emo-
tional/behavioral problems in young children is highlighted by
associations with unemployment and family income that may fur-
Background and aims.– It is believed that prolonged nature of treat-
ther contribute to risk for persistent problems
ment of epilepsy, stigma, and changes in brain activities due to
seizures and antiepileptics affect the behavior and lead to psy-
interest statement.
chopathology. The present study investigated the occurrence of
dysfunctional schema modes in people with epilepsy and its asso-
ciation with the comorbidity of psychiatric symptoms.
Methods.– The data collected from the 108 PWE from neurologi-
cal departments of various hospitals in Pakistan. The age range of
E-Poster Presentation: Rehabilitation and The purpose of this study is evaluation the effectiveness of restora-
psychoeducation - Part I tion the motor function of the wrist using investigated CMR.
Methods.– 96 patients with motor dysfunction were divided into
clinical (1) (54 patients) and control (2) (42 patients) compara-
ble groups. All patients received standard treatment. In addition,
E-PP0993 respondents from group-1 received the investigated CMR.
Rehabilitation-oriented diagnostics of Evaluations Methods: assessment of fine motor skills under the
personality development in stopwatch control, measuring the strength of the wrist muscles,
adolescents with adaptation disorders the disabilities of the arm, shoulder and hand (DASH) scale. All
V. Oleshkevich1 , N. Burlakova2* these methods were used before the start of rehabilitation and after
1 Scientific-Practical Children’s and Adolescents Mental Health Center completion.
n.a. G. Sukhareva, Department of Health Care, Moscow, Russia; 2 Results.– After the completion the respondents of group 1 showed
Lomonosov Moscow State University, Department of Neuro- and statistically significant higher results in increasing the strength of
Pahopsychology, Moscow, Russia the wrist, and by the DASH scale. The results of the analysis of
* Corresponding author. the fine motor skills in the two groups also showed statistically
significant differences: respondents of group-1 showed statisti-
Background and aims.– Traditional psychological diagnostics is cally significantly better results in comparison with group-2 in
aimed at detection of disturbances in mental processes and manipulating small objects during their retention and subsequent
functions; however, it appears insufficient for organization of reha- unfolding on the surface, while the results of gripping followed by
bilitation. retention of small objects did not have a statistical difference.
Methods.– During the research, mental disorders in children and Conclusions.– The investigated CMR can be a significant addition to
adolescents were examined under real conditions as well as their the standard program of rehabilitation measures in patients with
social environment, family structure, place of a child within the limb dysfunctions due to stroke and brain tumor.
family, relations between family members, etc. The authors argue Disclosure of interest.– The authors have not supplied a conflict of
that these social data are of vital importance for understanding of interest statement.
adolescent’s inner world and selfhood.
Results.– Mental disorders in adolescents could be better under-
stood after examination of developmental conditions, peculiarities E-PP0995
of interiorization, shaping of selfhood. Such an understanding is Behavioural and emotional impact of
cultural-historical in its nature and presupposes that it is possi- traumatic brain injury on quality of
ble to observe transformation of external social interactions into
structures of inner communication. Such an approach to the gen-
life: need of holistic rehabilitation in
esis of mental disorders allows to detect socio-cultural predictors india
indicating possible future disorder, such as: 1) situation of the only S. Chopra* , H. Kaur, A. Nehra
child in the single-parent family accompanied by conflict relations All India Institute of Medical Sciences, Clinical Neuropsychology, New
within the family; 2) longtime somatic diseases; 3) systematic over- Delhi, India
protection of different types, e.g. hyper-satisfaction of child’s needs,
etc.
Background and aims.– There are nearly 2 million survivors of Trau-
Conclusions.– Understanding mental disorders in adolescents from
matic Brain Injury (TBI) in India, a leading cause of disability and
the perspective of their age dynamics and manifestations of ado-
mental health issues. TBI can result in cognitive, physical, emotional
lescence crisis allows to refine diagnosis of mental disorders and
and behavioural impairments that can lead to permanent or tem-
opens new horizons in rehabilitation, which could be organized in
porary changes in functioning, leading to a decreased quality of life
a more productive way with integration of developmental psychol-
and increased caregivers’ burden.
ogy, psychiatry and clinical psychology. Many mental disorders in
Methods.– The study was initiated after obtaining ethical approval
adolescence can be better explained by peculiarities of patient’s
and Clinical Trials Registry of India clearance. Prior to recruit-
adolescence crisis than by the concept of mental disease.
ment, a written informed consent was obtained from each patient
and their primary caregiver. 49 TBI patients between 18–45 years
interest statement.
were randomly assigned to the control (CG) or intervention group
(IG). Detailed cognitive and psychological assessment revealed
cognitive deficits, depressive & anxiety symptoms, and decreased
E-PP0994
quality of life (QOL). A 6-week home-based indigenous holistic neu-
The mirror visual feedback, ropsychological rehabilitation given to the IG included cognitive
constraint-induced movement retraining, relaxation training, psycho-education, anger manage-
therapy and finger gymnastic in ment, vocational guidance, individual and family counselling.
rehabilitation of patients with motor Results.– Immediate and long-term follow-up (6 months) after
intervention showed significant improvements as compared to CG
dysfunction in wrist due to stroke or
in anxiety (p = 0.001); depression (p = 0.001); self-perceived QOL
brain tumor (p = 0.001); and caregivers-perceived dysfunction (p = 0.001). The
U. But-Husaim* , A. Yarosh, Y. Sirytsyna intervention also aided in the individuals’ to return to work.
Grodno State Medical University, Department of Medical Conclusions.– Only handful centres across the entire nation offer
Rehabilitation, Grodno, Belarus neuro-rehabilitation, and paucity of rehabilitation specialists, poor
awareness among health care professionals leads to the patients
Background and aims.– We have used a complex of medical rehabil- being discharged without addressing their rehabilitation needs.
itation (CMR) for patients with motor dysfunction of the wrist due TBI represents a continuum of management rather than an add-on
to stroke or brain tumor based on the Mirror Visual Feedback (MVF), optional facility. Human resource development and training med-
constraint-induced movement therapy (CIMT), original method of ical and para-medical professionals in the field should run parallel
wrist gymnastic and method of using latex rubber bands. so that rehabilitation needs are easily met.
Disclosure of interest.– The authors have not supplied a conflict of Objectives.– To study the representation of child’s mental illness in
interest statement. mothers hospitalized with him at the clinic;
Methods.– A questionnaire that examines the needs of the family
and readiness for work; “F-SOZU-22”; the composition “My Child”;
E-PP0996 Questionnaire “Prohibition of expression of feelings”.
The gender-related healthcare Results.– The leading need of parents at the stage of hospitalization
experiences of men with traumatic is the need to obtain complete information about the state of the
child; the next rank (a.s. is 3,786 and 3,929 out of 4) have needs for a
brain injury (TBI): a qualitative study
child survey and training in new strategies. 74% of the respondents
A. D’souza1* , V. Amodio2 , A. Fabricius2
1 say about the high need for help in taking the condition of the child,
University of Toronto, Rehabilitation Sciences Institute, Toronto,
and only 33%, according to experts, have a relatively high level of
Canada; 2 University Health Network, Research- Toronto
acceptance of what is happening to the child. The most “forbidden”
Rehabilitation Institute, Toronto, Canada
* Corresponding author. to the demonstration for all parents is the experience of sadness.
Attention is drawn to the low level of perception of social support;
Background and aims.– Research suggests that traumatic brain There are also significant inverse correlations between the need for
injury (TBI) recovery is impacted by gender-related factors. Such rest from the child and the level of instrumental support (r = 0.68
factors are also influential in the uptake of clinical interventions. and r = 0.742; p = 0.05).
This study explores the experiences of men with TBI by asking, Conclusions.– We visually demonstrate the unevenness and mosaic
“Using thematic analysis with a focus on gender, what are the of the image of the child’s illness and ambivalence in relation to the
healthcare experiences of men with TBI in the acute and chronic very fact of the disease; similar dynamics can be noted in practical
phases of recovery?” We aim to (1) understand how men view gen- - family and group work with parents.
der roles; (2) explore perceptions and behaviours regarding the Disclosure of interest.– The authors have not supplied a conflict of
impact of gender; and (3) understand knowledge gaps to inform interest statement.
educational materials.
Methods.– We conducted semi-structured interviews with partic-
ipants identifying as men who were diagnosed with TBI of any E-PP0998
severity. Participants who were non-English-speaking, or who dis- Psychoeducational intervention for
played impairments that would impede interview completion, perinatal depression: study protocol
were excluded. The sample consists of 12 acute (≤ three months of a randomized controlled trial
post-injury) and 10 chronic participants (> three months post- G. Fico* , L. Steardo, V. Caivano, F. Zinno, A. Vece, G. Sampogna, M.
injury). Luciano, A. Fiorillo
Results.– Thematic analysis was used to develop themes and University of Campania “Luigi Vanvitelli”, Psychiatry, Napoli, Italy
corresponding suggestions for educational materials. Hegemonic * Corresponding author.
masculinity was used as a guiding theoretical framework. Men’s’
experiences fell into six categories: impact of TBI on oneself, impact Background and aims.– Perinatal depression (PD) impacts nega-
on relationships, navigating the healthcare system, thoughts on tively on children in terms of adverse neonatal outcomes and on
professionals, participation in treatment, and views on gender. Pre- the wellbeing of women and their families. A few studies have eval-
liminary themes include performance of masculinity in recovery, uated the use of psychoeducational interventions in PD, although
motivations for return-to-work, and understandings of gender. the effectiveness of psychological and psychosocial treatments has
Conclusions.– Our results will inform patient-driven clini- already been demonstrated in different serious mental illness. Our
cian/caregiver materials, such as reframing of rehabilitation aims are: 1) to evaluate the efficacy of a psychoeducational fam-
goals as more ‘masculine’, and using men’s motivations to inform ily intervention compared to the best treatment option (BTO) in
goal-setting. Men’s understanding of gender can be used to strate- women affected by PD and their family members; 2) to identify
gically inform development of acceptable educational materials predictive factors of PD; 3) to improve relatives’ coping strategies
for patients. and functioning.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– All pregnant women attending the unit of Gynecology
interest statement. and Obstetrics of the University of Campania “L. Vanvitelli” will be
screened for PD using clinical interview and the Edinburgh Post-
partum Depression Scale (EPDS). Women with PD will be randomly
E-PP0997 allocated to either an experimental group, receiving a uni-familiar
The process of accepting a child’s psychoeducational intervention, or to a control group, receiving
mental illness in parents, hospitalized BTO. Patients will be assessed at baseline, 3, 6, 9 and 12 months
post-randomization. At each time, patients will complete several
with their children in a psychiatric
assessment tools to evaluate the severity of depressive and anxi-
hospital ety symptoms, the level of global functioning, the family members’
D. Dovbysh1,2* , M. Bebtschuk1 , M. Ermakova1 , E. Shishkina1 coping strategies and their of quality of life.
1 Scientific-practical Children’s and Adolescents Mental Health Center Results.– Patients receiving the experimental intervention will have
n.a. G. Sukhareva, Moscow Department of Health Care, Moscow, a greater reduction of the severity of depressive symptoms in com-
Russia, Psychiatry, Moscow, Russia; 2 Federal State Autonomous parison to those receiving BTO.
Educational Institution of Higher Education I.M. Sechenov First Conclusions.– We anticipate that the experimental approach will
Moscow State Medical University of the Ministry of Health of the help to improve the clinical, psychosocial and family management
Russian Federation Sechenov University, Faculty of Higher Nursing of PD.
Training, Psychology and Social Work, Moscow, Russia Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
Background and aims.– Accepting a child’s disease, an adequate
image of it - one of the key factors in family adherence to treatment
and an important goal for parents.
E-PP0999 Objectives.– to assess resilience, coping styles and self-esteem of

Comprehensive psychosocial patients admitted to our Psychiatry Ward. Moreover, to assess the
rehabilitation program in the relation among these three constructs.
Methods.– Methods: we started patients’ recruitment since January
community: evaluation of the 2018. All patients aged ≥ 18 years, admitted to the Psychiatry ward
effectiveness of the Maggiore della Carità University Hospital, were included in
T. Solokhina1 , V. Yastrebova2 , V. Golimbet3* the study, except those (1) with cognitive impairment; (2) foreign-
1 Mental Health Research Center, Head of Department of Mental ers with a poor knowledge of italian language. Clinicians gathered
Health Support Systems, Moscow, Russia; 2 Mental Health Research clinical and anamnestic information about patients, who were
Center, Mental Health Support Systems, Moscow, Russia; 3 Mental tested with self-administered questionnaires: Resilience Scale for
Health Research Center, Clinical Genetics Laboratory, Moscow, Russia Adults (RSA), Brief Cope and Rosenberg Self-Esteem Scale (RSES).
Results.– Results: data collection is still ongoing; to date, we
recruited 42 patients who fulfilled the above mentioned criteria.
Background and aims.– Today’s global trend is the development of
The sample currently consists in 27 females (64%), with a mean
community-oriented psychiatry, using resources of public organi-
average age of 48 years; on average, patients were hospitalized for
zations. The regional charitable public organization (RCPO) “Family
15 days; the most common diagnosis at admission were psychoses,
and Mental health” was established in 2002. Comprehensive long-
suicide attempt by poisoning, and neurotic or personality disorders.
term psychosocial rehabilitation program was implemented by this
Conclusions.– Conclusions: High resilience levels may positively
organization. The program includes psychoeducation, counseling,
influence outcome and treatment compliance. A more thorough
trainings, psychotherapy, family therapy, assistance in employ-
understanding of patients’ psychological resources can help clini-
ment, leisure.
cians personalizing their treatment plan.
The purpose of the study is to evaluate the effectiveness of this
program.
interest statement.
Methods.– Clinical, psychometric, molecular-genetic (immune sys-
tem genes and genes associated with social behavior, etc.),
immunological and statistical methods. The main group included E-PP1001
50 patients with schizophrenia who took part in the program.
The comparison group included 106 patients who had never been
Relationship between mindfulness
involved in rehabilitation programs. Patients of the both groups training during pregnancy and
were similar in their clinical and socio-demographic characteris- executive abilities in children
tics. S. Kiselev
Results.– The results demonstrated the significant differences Ural Federal University Named by the First President of Russia B.N.
between the two groups of patients. The participation in rehabili- Yelsin., Clinical Psychology and Psychophysiology, Ekaterinburg,
tation program improved compliance of patients, identified higher Russia
level of motivation and social functioning. The adaptive behavioral
coping strategies were developed in the process of social rehabilita-
tion. Statistically reliable decrease of the number of hospitalization Background and aims.– It is known that maternal anxiety during
was demonstrated. The study of genetic and immunological fac- pregnancy can affect child outcomes. We have shown that maternal
tors’ influence on the socio-psychological adaptation of patients is mindfulness training during pregnancy has positive effect on the
in progress. development of executive, language and memory abilities in 5–7
Conclusions.– RCPO «Family and Mental Health» contributes to the years old children (Kiselev, Volik, 2017). The goal of this study is
personal and social recovery of the rehabilitation program par- to evaluate the effect of the maternal mindfulness training during
ticipants. Public forms of patients with chronic mental disorders pregnancy on executive abilities in 7–8 years old children.
care should be considered as an important part of psychiatric care Methods.– In current study we included 24 women who partici-
system. pated in the maternal mindfulness training during pregnancy. The
Disclosure of interest.– The authors have not supplied a conflict of control group included 24 women who did not participate in this
interest statement. training during pregnancy. When the offspring of the target preg-
nancies were between 7 and 8 years of age, their executive abilities
was assessed by 4 subtests from NEPSY (Tower, Auditory Attention
E-PP1000 and Response Set, Visual Attention, Statue).
Results.– One-way ANOVA was used to reveal group differences in
Resilience, coping and self-esteem in
performing executive tasks. We have revealed the significant dif-
hospitalized psychiatric patients ferences (p < .05) between groups in 3 subtests from NEPSY (Tower,
C. Guerriero1* , C. Gramaglia1,2 , L. Girardi1 , C. Consol1 , M. Chiarelli Auditory Attention and Response Set, Visual Attention). The chil-
Serra1 , G. Bartolomei1 , E. Gambaro1 , A. Jona2 , V. Binda2 , A. Feggi2 , dren from the experimental group had better executive abilities.
P. Bergamasco2 , P. Zeppegno1,2 Conclusions.– These results suggest that maternal mindfulness
1 Università degli Studi del Piemonte Orientale, Department of
training during pregnancy may have positive effect on the devel-
Translational Medicine, Novara, Italy; 2 Maggiore della Carità di opment of executive abilities in 7–8 years old children.
Novara Hospital, SC Psichiatria, Novara, Italy The research was supported by Act 211 Government of the Russian
Federation, agreement 02.A03.21.0006.
Background and aims.– Introduction: Resilience is a multidis- Disclosure of interest.– The authors have not supplied a conflict of
ciplinary research topic, described as a positive adaptation to interest statement.
adverse events or the ability to maintain/regain mental health after
exposure to difficulties. Environmental, psychological, genetic, epi-
genetic and neuroendocrine issues may influence resilience. On the
other hand, resilience may affect the psychophysical well-being of
the individual and the outcome of patients suffering from psychi-
atric diseases, especially chronic and disabling ones.
E-PP1002 further rehabilitation: transfer of care over daily life, including

Attention deficits in adolescents after transportation on public transport and housekeeping, from rela-
traumatic brain injury of mild severity tives to patient with the use of cognitive and external compensatory
S. Kovtoniuk strategies. At the end of the program, a plan for stepwise return to
Moscow State University, Psychology, Moscow, Russia employment was developed in cooperation with the patient.
* Corresponding author. Conclusions.– This complex approach for rehabilitation resulted in
dramatic change in patients behavior: he took an active position,
Background and aims.– The effect of the traumatic brain injury of started to manage his own life and returned to part-time work.
mild severity (mTBI) on the attention deficits affects the educa- Research is supported by the Russian Foundation for Basic Research,
tional activities of adolescents in school. project No. 17-29-02169.
To study of attention deficits in adolescents after mTBI in acute Disclosure of interest.– The authors have not supplied a conflict of
period (3–5 days after trauma). interest statement.
Methods.– The study is based on the original set of techniques
designed by A.R. Luria. We used the technique of «Schulte table»
for the evaluation of 3 parameters: “average execution time”, “aver- E-PP1004
age number of digits found in 10 seconds” and “execution profile”.; Intra-individual effect of
3 1 patients with mTBI (mean age was 11,5 + 1,3) and 20 healthy community-based mental health
subjects (mean age was 12 + 1,5) took part in the study. rehabilitation services for
Results.– Analysis of the results showed that significant differences
were obtained for all three parameters (p < 0.05).
schizophrenia: findings from a
By the parameter “average time of completion”, 71.3% of patients retrospective cohort study
exceeded the standard time of completion (p = 0.001). I. Krieger1* , D. Tzur Bitan2,3 , R. Sharon-Garty4 , V.
“The average number of digits found in 10 seconds” by adolescents Baloush-Kleinman5 , L. Zamir6
1 Shalvata Mental Health Center, Managment, Hod Hasharon, Israel;
with BTWT was 4.6, while healthy adolescents were 5.3 (p = 0.011).
2 Shalvata Mental Health Center, Psychiatric ER, Hod Hasharon,
In 77.4% of subjects with TBI, the performance profile was with
explicit fluctuations in attention. The representatives of the control Israel; 3 Ariel University, Department of Behavioral Sciences, Ariel,
group have mostly uniform profile (p = 0.000). Israel; 4 Geha Mental Health Center, Managment, Petach Tikva,
Conclusions.– Further study of the features of attention and its dis- Israel; 5 Ministry of Health, Department of Mental Health, Jerusalem,
orders after traumatic brain injury of mild severity in adolescents Israel; 6 Shalvata Mental Health Center, Outpatients Unit, Hod
contributes to the creation of rehabilitation programs in order to Hasharon, Israel
improve the quality of life. * Corresponding author.
Background and aims.– Deliberative efforts are constantly made to
interest statement.
provide community-based mental health rehabilitation services to
people with mental health disabilities nationwide. In this study we
aimed to assess the effectiveness of rehabilitation services in Israel
E-Poster Presentation: Rehabilitation and by assessing the impact of utilization of rehabilitation services on
hospitalization rates among a cohort of patients diagnosed with
Psychoeducation - Part II/Sleep Disorders & Stress
schizophrenia.
Methods.– Data derived from the Clalit Health Services were crossed
with the Ministry of Health rehabilitation and psychiatric hospi-
E-PP1003 talization case registries. Patients utilizing rehabilitation services
Overcoming stroke-related disability were assessed for rates and durations of hospitalizations before
through rehabilitation: the usefulness and after the utilization of the rehabilitation services, and were
of neuropsysiological methods compared to patients who did not use these services (n = 185).
M. Kovyazina1* , N. Varako2 , E. Rasskazova2 , A. Trofimova2 , O. Mixed-model analyses of covariance (ANCOVA) were conducted
Dobrushina3 to assess changes in rates and durations of hospitalizations at the
1 Moscow State University, Psychology, Moscow, Russia; 2 Moscow beginning and end of the cohort period.
State University, Clinical psychology, Moscow, Russia; 3 International Results.– Patients who used rehabilitation services showed higher
Institute of Psychosomatic Health, Rehabilitation, Moscow, Russia rates and durations of hospitalizations prior to utilization of reha-
* Corresponding author. bilitation services, as well as higher decreases in number and
duration of hospitalizations after utilizing their rights to rehabil-
Background and aims.– Stroke leads to massive brain damage and itation services, as compared to patients who did not receive these
dramatically affects the quality of life. Efficacy of behaviorally- services.
oriented rehabilitation is limited. Neurophysiological methods Conclusions.– Schizophrenia patients tend to show a decreasing
can be utilized both for the goal of objectivization of the state trend in number and duration of hospitalizations over time. Yet
(quantitative EEG, qEEG) and to enhance brain functional state the utilization of rehabilitation services offers larger gains in hos-
(neurofeedback). To illustrate the effectiveness of these techniques pitalization prevention, primarily to schizophrenia patients who
in rehabilitation, we represent a case report. experience high rates and durations of hospitalizations at the
Methods.– Patient A., 30 years old, was admitted for rehabilitation beginning of illness. These findings provide additional support for
six month after hemorrhagic stroke due to rupture of an aneurism the necessity of rehabilitation services, primarily for patients with
of anterior communicating artery. Before the injury he was a suc- severe onset.
cessful dentist, but after was unable to cope with any employment Disclosure of interest.– The authors have not supplied a conflict of
and showed no motivation for daily activity. interest statement.
Results.– Neuropsychological assessment revealed regulatory
apraxia, memory impairment, executive disfunction. QEEG showed
decreased functional activity of anterior frontal areas, especially on
the left side. Treatment was started with neurofeedback sessions in
order to activate the frontal lobes and increase initiative. It allowed
E-PP1005 Table 1. Paired-samples t-test

Self-rating of psychological
capacities/soft skills and impairment
according to the ICF in psychosomatic
patients, as compared to the general
population
M. Linden
Charité University Medicine Berlin, Psychosomatic Medicine, Berlin,
Germany
Background and aims.– Chronic illness does not only result in

reduced well being but also in an impaired capacity to cope with
daily life, which again results in participation limitations. The Mini-
ICF-APP-S is a newly developed self rating instrument for the
assessment of capacity limitations or impairment of psychological
capacities or soft skills in the context of mental disorders. Conclusions.– To date, there is no evidence to support adopting
Methods.– A convenience sample of inpatients of a psychiatric- a single autism treatment program as the gold standard. Finally,
psychosomatic department (N = 1143) and unselected persons in the authors want to highlight the importance to use a personal-
a public train (N = 102) filled in the Mini-ICF-APP-S. ized approach, involving also the parents, tailored to deficits and
Results.– About 90% of the persons on the train rated their soft skill strengths of each autism spectrum disorder individual to determine
capacities positive, with lowest ratings in respect to endurance and the best possible improvement in the adaptive functioning.
self care. Patients with affectiv disorders rated their capacities as Disclosure of interest.– The authors have not supplied a conflict of
insuffienct in about 30%. This was especially true for flexibility, interest statement.
proactivity, endurance, assertivenes, social competence and self
care. There were significant differences between persons on work
or sick leave, elderly and younger, males and females and different E-PP1007
diagnostic groups. Internalized stigma and its
Conclusions.– Capacity limitations are an important feature of men- psychosocial correlates in Chinese
tal disorders. They are as burdensome and important for the
affected person as illness symptoms. They should get proper atten-
people with severe mental illness
Y. Min* , Z. Li
tion by therapists.
Peking Union Medical College, School of Nursing, Beijing, China
interest statement.
Background and aims.– The internalization of stigma leads to various
negative consequences among people with severe mental illness
E-PP1006
(SMI). The study aims to examine the internalized stigma and
Early rahabilitative intervention for the socio-demographic and psychosocial factors associated with it
autism spectrum disorder children: a among people with SMI in mainland China.
two years longitudinal study Methods.– A cross-sectional study was conducted in a sample of 104
S. Marini1* , P. Battist1 , T. D’Ambrogio2 , G. Sorge1 adults diagnosed with schizophrenia, bipolar disorder or schizoaf-
1 Il Cireneo Foundation for Autism, Il Cireneo Foundation for Autism, fective disorder in a tertiary psychiatric hospital in Beijing. The
Vasto, Italy; 2 National Health System, Child Neuro-Psychiatry participants were evaluated by the Chinese versions of the Inter-
Territorial Service, L’Aquila, Italy nalized Stigma of Mental Illness (ISMI), the Perceived Devaluation
* Corresponding author. and Discrimination (PDD) Scale and the Medical Outcomes Study
Social Support Survey (MOS-SSS). Correlation analysis and multi-
Background and aims.– Autism Spectrum Disorder (ASD) includes ple linear regression analysis were used to explore the contributing
a group of developmental disabilities characterized by patterns factors to the internalized stigma.
of delay and deviance in the development of social, communica- Results.– Overall, 23.3% of subjects had moderate-to-high ISMI
tive, cognitive skills and the presence of repetitive and stereotyped scores using a cut-off criterion (2.5 on a 1–4 scale) in this research
behaviors as well as restricted interests. sample. Persons with schizophrenia had significantly higher inter-
Methods.– Autism spectrum disorder children were recruited at the nalized stigma than those with bipolar disorder or schizoaffective
“Il Cireneo” Foundation for autism in Vasto, Italy. Fifteen patients disorder (p = 0.014). There was a positive correlation between the
(two females [13,3%] and thirteen males [86,7%], mean age = 39,533 internalized stigma and the perceived discrimination (r = 0.396,
months; SD = 6,8543) underwent a personalized rehabilitation pro- p < 0.001). Correlation between the internalized stigma and the
gram based on behavior therapy, neuro-psycho-motricity and social support was negative (r = −0.437, p < 0.001). Multiple lin-
speech therapy as international guidelines suggest, for two years. ear regression analysis indicated that higher levels of internalized
At the time of the enrollment, each child was younger than 48 stigma were associated with being elder (p = 0.013), lower fam-
months of age. Children were tested before the treatment and after ily income (p < 0.001), lower social support (p = 0.002) and higher
two years of the rehabilitative intervention. The Childhood Autism perceived discrimination (p < 0.001).
Rating Scale, the PsychoEducational Profile Third Edition (PEP-3) Conclusions.– The research results indicated that the age, family
and the Vineland Adaptative Behavior Scale (VABS) were used for income, social support, and perceived discrimination were closely
the clinical assessment before and after the rehabilitation treat- related to the internalized stigma of people with severe mental
ment. The Statistical Package for Social Sciences (SPSS, version 13) illness and these may be important factors considered for stigma
program was used for the statistical analysis. The paired-samples interventions in the future.
t-test was used to highlight the differences between the pre and Disclosure of interest.– The authors have not supplied a conflict of
post-treatment phases. interest statement.
Results.– See Table 1 for Results
E-PP1008 Methods.– 40 adolescents formed 4 groups: (1) raised in orphan-

How to reduce the mortality gap in age, (2) in centre for foster care, (3) in kinship care, (4) controls.
patients with severe mental Methods: Life Style Index, COPE questionnaire, self-assessment
of self-esteem (Dembo-Rubinstein method), projective drawings.
disorders? A study protocol for testing Quantitative and qualitative analyses of data were employed.
the efficacy of a new Results.– Significant differences were found between adolescents
psychoeducational intervention raised in family and institutional care in level of mature defense
B. Pocai* , C. Palummo, V. Giallonardo, V. Del Vecchio, M. Luciano, mechanisms and in prevalence of particular defense mechanisms
G. Borriello, M. Savorani, L. Giannelli, A. Fiorillo and coping strategies, with avoidant coping strategies, defense
University of Campania Luigi Vanvitelli, Psychiatry, Naples, Italy mechanism of denial and low reflexivity dominating in later groups.
* Corresponding author. Overall self-esteem ratings were higher in family care. Adoles-
cents in institutional care tend to use more social and instrumental
Background and aims.– support while controls rely on internal resources. The group of ado-
Background.– Patients with severe mental disorders (SMD) die on lescents in kinship care also showed differences from controls:
average 20 years earlier than the general population. This mortality they tend to have a higher tension of defense mechanisms, but
gap is mainly due to the higher prevalence of physical diseases and also higher (unrealistic) self-esteem and wider repertory of defense
unhealthy lifestyle behaviors, such as smoking, sedentary behav- mechanisms used.
ior and unhealthy lifestyle pattern. Therefore, there is the need Conclusions.– Results suggest that current strategies of social sup-
to develop psychoeducational intervention for improving lifestyle port in Russia could contribute to the poor reflexivity, primitive
behaviours. coping strategies and an excessive reliance on adults in the expense
Aims.– To evaluate the efficacy of a new psychosocial, manu- of inner resources in institutional care and a lack of elaboration of
alised group intervention compared to a brief psychoeducational traumatic experiences in kinship care.
group intervention in a community sample of obese or overweight Disclosure of interest.– The authors have not supplied a conflict of
patients with SMD. interest statement.
Methods.– This trial is a multicentric, randomized, controlled
and blind trial carried out in six Italian Universities and funded
by the Italian Ministry of Health. All patients are assessed six E-PP1010
times: at baseline; 2 months post-randomization; 4 months Outdoor therapeutic environment in a
post-randomization; 6 months post-randomization; 12 months
post-randomization; and 24 months post-randomization. The pri-
psychiatric hospital
V. Sendula Jengic1* , J. Hodak2
mary outcome is the change of BMI. 1 Psihijatrijska Bolnica Rab, Department for Forensic Psychiatry, Rab,
Results.– The hypothesis is that the LIFESTYLE intervention will
Croatia; 2 Rab Psychiatric Hospital, Department for Research and
be more effective than the psychoeducational group intervention
Teaching, Rab, Croatia
in reducing the BMI. We expect a mean difference between the
two groups of at least one point at BMI. Secondary outcomes are:
improvements in eating, smoking and sleeping habits; increased Background and aims.– Modern psychiatric treatment is no longer
physical activity; improvement of personal and social function- limited to mere reduction of symptoms and psychological suffer-
ing; reduced severity of physical comorbidities; better adherence ing, but is oriented towards achieving a balance of mind and body
to medications. The expected sample size consists of 420 patients, by reaffirmation of those potentials of the personality which facili-
which will be allocated with a 1:1 ratio randomization between the tate a high quality and speedy rehabilitation and resocialization and
two groups. to increase coping mechanisms for patients. This is achieved by a
Conclusions.– We expect that LIFESTYLE intervention will help to holistic and personalized approach, life coaching, social skills train-
provide a new instrument for improving healthy behaviours in ing and other activities. The concept of treatment which combines
patients with SMD. new and innovative models of treatment with the classic approach
Disclosure of interest.– The authors have not supplied a conflict of with psychopharmacs and psychotherapy is the most appreciated
interest statement. and recognized. The natural resources provide a key for rehabilita-
tion and mind-body balance, over bridging anxiety, depression, and
many neurological disorders by exposure to the nonverbal and pre-
E-PP1009
verbal archetypal and multisensory stimuli. To be in an institution
Impact of the experience of staying in but not institutionalized is a challenge in the field of psychiatry and
social care institutions on coping cognitive neuroscience where even more severe disorders, those
behavior of adolescents with that require hospitalization, can be treated by maximal utilization
of outdoor resources and facilitation of the physical and mental
emotional deprivation
return to nature and experience of harmony. Rab Psychiatric Hos-
L.S. Pechnikova1 , E. Zhuykova2 , A. Ryzhov1* , E.T. Sokolova1 , P.
pital is the first mental health institution in Croatia to introduce
Mavrenkova3
1 Lomonosov MSU, Psychology, Moscow, Russia; 2 Psychological therapeutic gardens as a complement to traditional therapies. The
gardens serve for physical therapy, animal-assisted therapy, hor-
Institute Russian Academy of Education, Adolescent psychology
ticultural therapy, as well as for socialization or a place for retreat
laboratory, Moscow, Russia; 3 Lobnya Social Rehabilitation Center for
in solitude. The author will present a five-year project of creation
Minors, Psychological Department, Lobnya, Russia
of therapeutic gardens as a result of interdisciplinary collabora-
tion of University of Washington (USA), local community and Rab
Background and aims.– The need to develop targeted psycho-social Psychiatric Hospital.
rehabilitation programs for adolescents left without parental care Methods.– N/A
grounds problem solving skills study. They could be conceived as Results.– N/A
an important resource adolescents left without supportive parent Conclusions.– N/A
rely on, determining further social adaptation. Objectives: To study Disclosure of interest.– The authors have not supplied a conflict of
differences between adolescents in family and institutional care in interest statement.
coping skills, defense mechanisms and self-esteem.
E-PP1011 Methods.– 210 children (2.5–18, mean age 10 + 2) with STBI,

Effect of complex rehabilitation hypoxia, hydrocephalia. All children had interdisciplinary approach
method on psycho-emotional state of and standard medications in early rehabilitation. Educational and
psychopathological methods were used with scales: Rancho Los
patients with a history of cerebral Amigos Scale (Hagen C., Malkmus D., 1989), Coma Recovery Scale-
stroke Revised (Giacino J.T., Kalmar K., 2004), Scale mental recovery by
A. Yarosh* , U. But-Husaim, Y. Sirytsyna Dobrokhotova T. (1985), Method of studying mental activity by A.V.
Grodno State Medical University, Department of Medical Zakrepina (MSMA, 2015).
Rehabilitation, Grodno, Belarus Results.– 3 groups of children with variants of mental activity
* Corresponding author. depending on the degree of disorders: (1) with high values of
mental activity (37, 18%): physical activity, understanding and
Background and aims.– Frequent sequelae of cerebral stroke (CS) are
implementation of simple instructions, emotional responses. The
emotional disorders.
clinical status was: minimal consciousness (MC)“+”. (2) with
The purpose of this study is restoration of emotional state in
medium values of mental activity (67, 32%): sensomotor actions not
patients after CS.
related to instructions, low and rare emotional reactions. In clini-
Methods.– The study was conducted in the first rehabilitation period
cal: MC “-”, more towards “+”. (3) with low values of mental activity
using Hospital anxiety and depression scales.
(106, 50%): physical, cognitive and sensory actions are limited. In
56 patients with CS were allocated into two comparison groups
clinical: MC “-”.
matched by gender and age and examined.
Conclusions.– Evaluation of mental activity with an interdis-
Control Group I — 22 patients received common rehabilitation
ciplinary approach will allow to differentiate the tasks of
treatment.
rehabilitation of children after severe traumatic brain damages.
Clinical Group II — 34 patients received proposed plan of rehabilita-
Understanding the variability of mental activity will increase the
tion treatment, which included art therapy, mirror visual feedback
effectiveness of rehabilitation at early stage, reduce the risk of long-
(MVF) therapy, sessions of exposure to polarised polychromatic
term post-traumatic consequences.
light of the eyes region.
Results.– Decreasing in anxiety level score was more evident in
interest statement.
Group II after MR course. All the changes were statistically signifi-
cant. Before MR course, normal anxiety level was recorded in 50.0%
of patients in both groups. Upon completion of the MR course, nor- E-PP1013
mal anxiety level was observed in 72.7% (I) and 82.1% (II) of patients,
and subclinical and clinical anxiety level were observed in 18.2% (I)
Effect of chronotype on academical
and 9.1% (II) of patients, respectively. Comparison of Group I and performance of medical students
Group II results of depressive reaction showed also statistically sig- B. Darbaz1* , A. Topal1 , C. Sahbaz2
1 Bezmialem Vakif University, School of Medicine, Istanbul, Turkey; 2
nificant improvement in Group II patients, which is suggestive of
more effective use of the proposed method compared to conven- Bezmialem Vakif University, Department of Psychiatry, Istanbul,
tional methods used for correction of depressive reaction level in Turkey
patients with a history of stroke. * Corresponding author.
Conclusions.– Complex use of such rehabilitation methods as art
Background and aims.– Chronotype is under the control of the cir-
therapy, MVF, and polarised polychromatic light are especially
cadian clock and refers to sleep, wake and diurnal habits. School
promising to increase effectiveness of MR in patients after CS since
performance is influenced by many factors as well as executive
they have positive influence on psycho-emotional state of patients.
functions and sleep-wake habits. In our study, we investigated the
relationship between chronotype, executive functions and school
interest statement.
performance of medical students.
Methods.– One hundred eighty-four students from Istanbul Bezmi-
E-PP1012 alem Vakif University School of Medicine 4th, 5th and 6th years
were evaluated through the use of The Morningness Eveningness
Mental activity in children after Questionnaire (MEQ) and the Stroop Test. To measure the academic
severe brain injury at an early stage of performance GPA scores was provided from school authorities.
rehabilitation Results.– In our sample, there are no significance according to gen-
Y. Sidneva1 , A. Zakrepina2* , M. Bratkova3 der (93 Female/91 Male) within GPA scores (p = 0.262). The GPA
1 Clinical and Research Institute of Emergency Pediatric Surgery and scores were significantly lower in the evening chronotype than in
Trauma, N.N. Burdenko National Medical Research Center of the morning (p = 0.013) and intermediate chronotypes (p = 0.009).
Neurosurgery, Neurorehabilitation and Recovery Treatment, The Stroop test scores did not differ significantly between chrono-
Neurosurgery, Moscow, Russia; 2 Clinical and Research Institute of types. In the regression analysis, GPA score was only related to
Emergency Pediatric Surgery and Trauma- Institute of Correctional age (p = 0.001) and MEQ total score (p = 0.48). Pearson correlations
Pedagogy of the Russian Academy of Education, Department of were calculated, MEQ total score is positively correlated (p:0.004)
Neurorehabilitation and Recovery Treatment, Moscow, Russia; 3 with GPA, but The Stroop Reading Speed Factor (p = 0.612), Color-
Clinical and Research Institute of Emergency Pediatric Surgery and Naming Factor (p = 0.326) and Interference Factor (p = 0.405) have
Trauma, Institute of Correctional Pedagogy of the Russian Academy of no significant correlations with GPA.
Education, Moscow City University, Department of Conclusions.– Our results suggested that the academic performance
Neurorehabilitation and Recovery Treatment, Moscow, Russia being affected closely by chronotypes more than gender and exec-
* Corresponding author. utive functions. Future studies need to make this relationship
between sleep-wake habit and academic achievement clear.
Background and aims.– Recovery of mental activity in children after Disclosure of interest.– The authors have not supplied a conflict of
severe traumatic brain damages (STBI) has its own characteris- interest statement.
tics. The study of disorders will allow the use of a differentiated
approach to the recovery treatment.
Objective.– To whom it may concern: study the variants of mental
activity in children after STBI.
E-PP1014 E-PP1016
Prevalence of poor sleep quality in a Impact of sleep disorders and other
sample of the Portuguese population factors on the quality of life in general
M. Viana, C. Duarte* , C. Madeira-Sério, L. Lemos, H. Espirito-Santo population: a cross-sectional study
Instituto Superior Miguel Torga, Psychology, Coimbra, Portugal S. Hallit1 , A. Hajj2* , H. Sacre3 , G. Al Karaki1 , D. Malaeb4 , N. Kheir5 ,
* Corresponding author. P. Salameh6 , R. Hallit1
1 Holy Spirit University of Kaslik USEK, Faculty of Medicine and
Background and aims.– Sleep has shown to have a significant impact
Medical Sciences, Jounieh, Lebanon; 2 Saint-Joseph University,
on the somatic and psychological systems contributing to several
Laboratory of Pharmacology, Clinical Pharmacy and Quality Control
common problems in the modern society. This study aims to ana-
of Drugs, Faculty of Pharmacy, Beirut, Lebanon; 3 Order of
lyze the prevalence of poor sleep quality in an online sample of the
Pharmacists in Lebanon, Drug Information Center, Beirut, Lebanon; 4
Portuguese population.
Lebanese International University, School of Pharmacy, Beirut,
Methods.– 739 subjects, between the ages of 19 and 98 years, were
Lebanon; 5 Lebanese University, Faculty of Sciences, Fanar, Lebanon;
assessed through a sociodemographic questionnaire and the Pitts- 6 Lebanese University, Faculty of Pharmacy, Beirut, Lebanon
burgh Sleep Quality Index (PSQI) in an internet survey. Cutoff points
were calculated based on the distribution of continuous values
(median value) to study the prevalence of poor sleep quality. Background and aims.– Sleep disorders, particularly insomnia, are
Results.– Differences in sleep quality were found on sex and marital currently recognized as a major public health concern with a dev-
status. Female and the ones with a partner presented higher lev- astating impact on the quality of life of patients (QOL). The aim of
els of poor sleep quality. Statistically significant correlations were our study was to assess if insomnia, along with other factors, can
found between PSQI and working hours, with subjects that work impact the physical and mental QOL of the general population.
on shifts having a higher poor quality of sleep. Methods.– A cross-sectional study was carried out between August
Conclusions.– The results showed that women, subjects with a part- 2017 and April 2018, using a questionnaire and all participants
ner, and the ones who work on shifts have a higher prevalence of signed a written informed consent. Different validated scales were
poor sleep quality. Results have repercussions for future research used to explore psychological factors (physical and mental distress,
and treatment of poor sleep quality. anxiety, depression), insomnia, and the QOL of patients (SF-12-PCS
Disclosure of interest.– The authors have not supplied a conflict of for the physical component and SF-12-MCS for the mental compo-
interest statement. nent).
Results.– A total of 756 individuals were included (65% females).
A first linear regression, using the physical QOL as the
E-PP1015 dependent variable, showed that having a family insomnia
Sleep disturbances and cognitive problems was significantly associated with an increase in
impairment in alcohol addicted the SF-12-PCS score (Beta = 1.037; p = 0.041), whereas increased
women in Southern Bulgaria stress (Beta = −0.056; p = 0.031) and increased insomnia sever-
V. Giannouli1* , D. Ivanova2 ity (Beta = −0.135; p = 0.016) were significantly associated with a
1 Organisation Against Drugs, Okana, Athens, Greece; 2 South-West decrease in that score. A second linear regression, using the SF-12-
University “Neofit Rilski”, Department of Psychology, Blagoevgrad, MCS score as dependent variable, showed that having a psychiatric
Bulgaria disease was associated with an increase in the SF-12-MCS score
* Corresponding author. (Beta = 1.951; p = 0.041). Ageing and having a chronic pain was sig-
nificantly associated with a decrease in that score (Beta = −0.048;
Background and aims.– Sleep and cognitive problems in patients p < 0.001 and Beta = −1.344; p = 0.028 respectively).
suffering from alcohol dependence are usual, but until now no sys- Conclusions.– This study adds to the evidence that insomnia, along
tematic examination of the aforementioned problems with Lesch with other factors can have a detrimental impact on the QOL and
alcoholism typology has been made. The aim of this study is to highlights the importance of managing all contributing/associated
determine associations between the Lesch typology, sleep dis- factors with insomnia for a personalized treatment of patients with
turbances and self-reported cognitive impairment in a sample of sleep disorders.
alcohol dependent women in Southern Bulgaria. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– We examined a total of fifty-three women from the interest statement.
Municipal Council on Drug Addiction in Blagoevgrad. All par-
ticipants had a diagnosis of alcohol dependence (Mage = 43.84,
SDage = 9.48; Myears of education = 15.11, SDyears of education = 3.21; E-PP1017
Myears of addiction 12, SDyears of addiction = 3.56) and were assessed Correlation between parameters of
with the Bulgarian version of the Lesch Alcoholism Typology – emotional regulation and daytime
Questionnaire (LAT).
sleepiness in university students
Results.– Results indicated that there is no statistically strong rela-
E. Kadric* , D. Djuric, N. Mujezinovic, I. Pantic
tionship between the Lesch type (four types), cognitive impairment
University of Belgrade, Faculty of Medicine, Institute of Medical
as measured by self-reports (none, slight and severe), and sleep
Physiology, Belgrade, Serbia
problems (none, difficulties falling asleep and interrupted sleep).
Conclusions.– According to the above results, women with alcohol
dependence of a specific Lesch type do not report more cognitive Background and aims.– Despite extensive research, the exact rela-
problems, neither sleep problems which according to the scientific tionship between sleep and emotional regulation remains unclear.
literature may indicate brain dysfunction. The implications of our It is unknown if daytime sleepiness is in any way related to
findings include the need for more integrated approaches to sleep processes involved in monitoring, evaluating, and modifying emo-
problem assessment as well as a more detailed cognitive examina- tional reactions. In this work, we aimed to test the existence and
tion in this specific population in order to unravel the links with strength of correlation between determinants of emotional regula-
other relevant variables. tion such as expressive suppression and cognitive reappraisal, and
Disclosure of interest.– The authors have not supplied a conflict of daytime sleepiness in healthy young adults.
interest statement.
Methods.– An observational, cross-sectional study was performed Psychosomatik, Zürich, Switzerland; 3 Carl von Ossietzky University
on a sample of 344 participants, students from the University of Bel- Oldenburg, Department of Music, Oldenburg, Germany; 4 Center for
grade, Serbia (average age 22.1 ± 4.8 years). Expressive suppression Music in the Brain, Aarhus University, Department of Clinical
and cognitive reappraisal were evaluated using Emotion Regula- Medicine, Aarhus, Denmark
tion Questionnaire (ERQ). Daytime sleepiness was assessed using * Corresponding author.
Epworth Sleepiness Scale (ESS). Other sleep-related data, such as
total 24 h sleep time, were also obtained. Background and aims.– High quality sleep is fundamental to qual-
Results.– The results indicate that there is a statistically significant ity of life and wellbeing. Sleep disorders are correlated with a
positive correlation between cognitive reappraisal score and ESS higher risk of mental health problems. Moreover, sleeping diffi-
score (p < 0.05). No such correlation was observed between ESS culties often persist after successful psychiatric treatment. Current
score and expressive suppression (p > 0.05). Total 24 h sleep time treatment strategies in clinical and non-clinical practices, tend
was not significantly associated with either expressive suppression, to focus on pharmaceutical medication only. However, the Euro-
or cognitive reappraisal. pean guideline for the diagnosis and treatment of insomnia clearly
Conclusions.– Cognitive reappraisal is significantly related to day- recommends non-pharmacological approaches such as cognitive
time sleepiness in university students. To our knowledge, this is behavioural therapy. The basic idea is to activate patients internal
the first study to investigate the relationship between daytime resources for self-regulation. Music can be seen as one such internal
sleepiness and indicators of emotional regulation in a population resource which for long has been ascribed cognitive and affective
of university students. The results represent a basis for further value to improve mental health. The aim of the communication is to
research in the areas of sleep and emotion psychology. highlight the potential benefits of music listening in the treatment
Disclosure of interest.– The authors have not supplied a conflict of of insomnia.
interest statement. Methods.– A summary of basic research concerning correlation
between chronobiology, sleep and music, is given from a psychiatric
perspective. Recent music psychology research suggests a range of
E-PP1018 mechanisms which potentially enhance psychological wellbeing
Disorders of cicardian rhytms in and self-regulation, which could address some of the symptoms
characterizing sleep disorders. These mechanisms can provide an
children with autism spectrum
explanation for the positive effect of music as sleep aid as docu-
disorders mented by an increasing number of studies.
K.D. Lucci Results.– We present theoretical and empirical approaches to music
Warsaw Medical University, Second Medical Faculty, Warsaw, Poland and sleep which include a critical review of clinical research in the
field emphasising psychiatric populations. Finally, implications for
Background and aims.– The main goal of the project is to examine
implementation of music in clinical psychiatry including musical,
sleep disorders in children and adolescents in the autism spectrum,
and ethical perspectives are discussed.
and the possible connections of these disorders with sensory, anx-
Conclusions.– Conclusions on chronobiological perspectives, the-
iety and depression disorders. Circadian rhythm sleep disorders
oretical and clinical research findings in music medicine and
(CRSD) are known to affect a great number of ASD patients, however
perspectives for clinical implications in psychiatry.
previous research has not responded to how much this is due to
family factors, and if there is a comorbidity with mood and sensory
interest statement.
disorders.
Methods.– 100 ASD children recruited from the Children’s Hos-
pital held by the Warsaw Medical University, and 100 children
recruited from local schools. Both groups will be tested alongside E-Poster Presentation: Research Methodology -
their healthy siblings. All children have to be between 8 and 18
Part II
years of age, have an IQ of 70 and above, and have not been diag-
nosed for other psychiatric or neurological disorders. Participants
must have basic communication skills.
E-PP1020
First, all children will be tested against ASD using the newest ver-
sion of ADOS 2. Then, children will be tested against mood and Qualitative analysis in psychiatry
sensory disorders that are known to affect sleep. All children will H. Sikira1 , A. Dzubur Kulenovic2* , M. Muhic1 , E. Smajic1 , E. Ribic1 ,
have to fill sleep diaries according to the instructions, and a new S. Slatina1
1 University of Sarajevo Clinical Center, Institute for Research and
device measuring cicardian rhythms will be given in order to test
children’s sleep movements. Development, Sarajevo, Bosnia, Herzegovina; 2 University of Sarajevo
Results.– There will be a significant difference between sleep of chil- Clinical Center, Department of Psychiatry, Sarajevo, Bosnia,
dren with ASD and their siblings compared to healthy subjects and Herzegovina
their siblings. * Corresponding author.
Conclusions.– Verifying the existing research hypotheses will allow
Background and aims.– Qualitative analysis is a type of research
a better understanding of the nature of sleep disorders and will
methodology that is very utilized in the scientific research nowa-
explain the causes of circadian rhythm disorders in people with
days, peculiarly in psychiatry. It provides the answer on the
ASD.
research question – how the change happens, and not how fre-
quent the changes are like in the quantitative analysis usage. The
interest statement.
aim of the qualitative analysis is to describe, understand, and inter-
pret the facts and their context, without exploring and searching
E-PP1019 for causal consequential relationship.
Methods.– A literature research through the relevant databases
Music and sleep: improving mental using previously defined criteria.
health Results.– On the basis of the literature review, qualitative anal-
H.N. Lund1* , A. Pöpel2 , G. Kreutz3 , K.V. Jespersen4 ysis represents very challenging analysis method, according to
1The Psychiatric Research Unit, Aalborg University Hospital, Clinic its specificity. Methodological approach is interdisciplinary and
South, Aalborg, Denmark; 2 Sanatorium Kilchberg, Zentrum für methodology is very demanding to learn, as the research itself is for
the implementation. Despite that, these types of research are often E-PP1022
published in relevant scientific journals with high impact factor. A systematized comparison of
Qualitative research contributes to better understanding of indi-
validation methods of psychiatric
viduals with mental illnesses and their families, bringing the new
aspects in the field of prevention, diagnostics, and treatment of psy-
diagnoses in registers
chiatric illness. Qualitative research has significant role in rising up A.F. Kemp1* , B. Mortensen Risskov2 , C. Vasarhelyi Croucher1 , S.
new questions. It also indicates and emphasizes interesting and Koch Vinkel3
1 Region of Southern Denmark, Psychiatric Research Academy,
individual phenomena as opposed to quantitative analysis which
is more often considered as insufficient nowadays. Odense, Denmark; 2 University of Southern Denmark, Medicine,
Conclusions.– Qualitative analysis significantly contributes to Odense, Denmark; 3 Mental Health Services in the Capital Region of
answers to challenging questions posed by psychiatry of the 21st Denmark, Child and Adolescent Mental Health Centre, Copenhagen,
century, and raises new issues that lead to the improvement of Denmark
individual-oriented treatment. * Corresponding author.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– Register based studies have been widely
interest statement. used to illuminate eg. the prevalence, incidence and outcome of
psychiatric disorders. To draw conclusions from register studies,
it is crucial to have knowledge of the validity of diagnoses. Valida-
E-PP1021
tion of diagnoses has been done in different ways in registers. These
Distribution of circulating micro RNAs non-homogeneous assessments lead to a difference in biases which
among extracellular blood complicates a comparison.
compartments in patients with major Aims.– To develop a model for systematic scoring and comparing
depressive disorder compared to of methods of validation of psychiatric register diagnoses.
Methods.– This is a literature study. A series of variables will be
controls identified from the literature, and a scoring system will be defined.
C. Homorogan1* , V.R. Enatescu1 , A. Marcu2 , E. Seclaman2 , C.
The variables will include eg. biases, blinding and confounding. A
Marian2
1 Victor Babes University of Medicine and Pharmacy systematized literature search will be conducted to identify stud-
ies validating register diagnoses. The validation methods of these
Timisoara-Discipline of Psychiatry, Timisoara, Romania and Eduard
studies will be scored by three raters on the series of variables iden-
Pamfil Psychiatry Clinic, Timisoara County Hospital, Timisoara,
tified. A portion of the studies will be scored by external raters and
Romania, Psychiatry, Timisoara, Romania; 2 Victor Babes University
a kappa will be calculated both between the three internal raters
of Medicine and Pharmacy Timisoara, Romania, Biochemistry,
and between the internal and external raters. This will be done to
Timisoara, Romania
validate the scoring tool.
Results.– The results are under conduction.
Background and aims.– Conclusions.– We expect to identify validation methods to be pre-
Introduction.– Previous investigations showed that micro RNAs ferred compared to others and thereby provide future researchers
(miR) are potential biomarkers in Major Depression Disorder with a tool to assess validation methods.
(MDD). There is a high degree of heterogeneity in the literature Disclosure of interest.– The authors have not supplied a conflict of
regarding distribution in different blood compartments, suggesting interest statement.
that are differentially expressed in patients with MDD compared to
healthy controls.
E-PP1023
Objectives.– To investigate miR-26a and miR-494 in extracellular
blood compartments of MDD patients before treatment and after Syndromic approach to astimate
12 weeks of treatment, compared to healthy controls. effects after traumatic brain injury of
Methods.– We assessed the relative abundance of miR-26a and miR- mild severity in adolescents
494 in total plasma (TP), exosomes from plasma, and exosome S. Kovtoniuk
depleted plasma (EDP) in 11 healthy controls compared to 11 MDD Moscow State University, Psychology, Moscow, Russia
patients before, and after 12 weeks of antidepressant monophar-
macy with escitalopram. A structured diagnostic interview and Background and aims.– The effect of the traumatic brain injury of
Hamilton depression rating scale (HAM-D-17) were done. Blood mild severity (mTBI) on the cognitive functions affects the educa-
samples were collected on EDTA anticoagulant. Total RNA was tional activities of adolescents in school and the quality of life in
extracted from extracellular blood compartments and miR expres- general.
sion was determined by real time PCR. To compare among groups To study the violations and to trace the dynamics of recovery higher
was used the t test, and to calculate the relative expression of miRs mental functions (HMF) after mTBI in adolescents with neuropsy-
the elta-delta Ct method was used. chological syndrome in the range of up to one year.
Results.– We found miR-26a to be statistically significantly down- Methods.– The study is based on the original set of techniques
regulated in TP of MDD patients compared to controls (P < 0.05); designed by A.R. Luria. We focused on assessing the status of vari-
also the same changes in EDP, but not in exosomes. MiR-494 was ous components of the HMF. We also studied of the mental activity
upregulated in the EDP fraction from patients with MDD after the in its regulatory and dynamic aspects.
treatment compared to controls. 31 patients with mTBI (mean age was 11,5 + 1,3) and 20 healthy
Conclusions.– In this pilot study were found significant differences subjects (mean age was 12 + 1,5) took part in the study.
in expression of miR-26a and miR-494 among different blood com- Results.– Analysis of the results showed that violations of HMF in
partments in MDD patients compared to controls. Further studies the acute period were represented by three types of syndromes. The
are needed for definitive conclusions of these results. leading place in each syndrome is occupied by deficiency symptoms
Disclosure of interest.– The authors have not supplied a conflict of of non-specific brain structures. Research of dynamics of recovery
interest statement. HMF demonstrated the symptoms related to deficiency of parietal-
temporal-occipital area are reducing for the first month, as well as
the symptoms of the anterior brain. After six months we observed
the decrease all symptoms from cortical structures, but the symp-
toms persist in the form of fatigue, reduction the rate of mental E-PP1025
activity, difficulty in concentration. comparison of wrist tapping
Conclusions.– Application of neuropsychological approach to the
parameters in adults with and without
diagnosis and recovery of deficit cognitive function allows to
describe the symptoms and to identify their hierarchy in the struc-
anxiety using a original methodology
ture of violations. N. Shnayder1* , E. Narodova2 , D. Dmitrenko3 , A. Usoltseva3 , E.
Disclosure of interest.– The authors have not supplied a conflict of Erakhtin4
1 Bekhterev National Medical Research Center of Psychiatry and
interest statement.
Neurology, Personalized Psychiatry and Neurology, Saint Petersburg,
Russia; 2 Voyno-Yasenetsky Krasnoyarsk State Medical University,
E-PP1024 Neurology with Course Neurorehabilitation, Krasnoyarsk, Russia; 3
Voyno-Yasenetsky Krasnoyarsk State Medical University, Medical
How do we individualize psychiatric
Genetics and Clinical Neurophysiology, Krasnoyarsk, Russia; 4 Clinical
care? Understanding the personal Ambulance Hospital No. 6, Neurosurgery, Krasnoyarsk, Russia
experience of mental illness - a call for * Corresponding author.
qualitative research
K. Laxton Background and aims.– Tapping is a psychomotor test that can be
University of Stellenbosch, Department of Psychiatry, Cape Town, used to assess the psychophysiological brain functions, in particu-
South Africa lar, the time perception.
Objectives of the present study is to explore the effect of anxiety
Background and aims.– Medical research is historically rooted in on the parameters of wrist tapping in healthy adults.
quantitative methodological design, essentially testing an existing Methods.– We examined 60 healthy adults without neurological
research question. Quantitative research aims to include large sam- and endocrinological pathology. The sample was divided into 2
ple sizes. The validity and applicability of the results are dependent groups: 1-st group included 33 healthy adults without anxiety and
upon statistically supported measurable outcomes, to the detri- depression symptoms according to the test results; 2-nd group
ment of deeper and richer meanings and interpretations of the included 27 healthy adults with subclinically expressed anxiety
data. according to the test results. The test was conducted using hospital
Psychiatry is both science and art. Each individual experience of a anxiety and depression scale HADS. Parameters of wrist tapping
mental illness or psychiatric symptom has a subjective interpreta- were studied using a modified original technique “Method of
tion. Culture, religion, language and ethnicity play important roles exogenous rhythmic stimulation influence on an individual human
in this experience and recovery for a patient. rhythm” (Fig. 1). Reference corridors of the wrist tapping charac-
This presentation aims to advocate for qualitative research design, teristics were also studied.
for investigators to focus on smaller sample sizes and gain deeper, Results.– We found statistically significant effect of anxiety on
richer and personalized accounts of symptoms and distress. both quantitative and qualitative indicators of individual rhythm
Methods.– To present the basic outline of qualitative methodologi- in healthy study participants (Table 1). Thus, with the subsequent
cal design and motivate for its value in psychiatric research. use of the reference corridors of the wrist tapping characteristics,
we can ignore gender differences in the group of adult volunteers.
Also, it is necessary to take into account the effect of the anxiety
presence at the time of the study, since anxiety affects the quantita-
tive and qualitative parameters of wrist tapping (individual rhythm
and rhythm stability).
Conclusions.– The obtained parameters of wrist tapping method-
ology can be used in the future for the diagnosis and
neurorehabilitation in adult patients with various psychoneurolog-
ical disorders.
interest statement.
E-PP1026
Figure 1. Qualitative research. Multivariate association between
Results.– By focusing on the value of qualitative research, unique bipolar spectrum, schizotypy and
people groups will be provided with a voice and treatment modal- chronotype revealed with the use of
ities may be created to reach those whose experience of living cluster analysis
with a psychiatric illness cannot be “boxed” into the Westernized A. Tereszko1* , A. Chrobak Chrobak1 , Z. Sołtys2 , M. Siwek3 , D.
understanding of mental disorders (Fig. 1). Dudek1
Conclusions.– The practice of psychiatry is both science and art. 1 Jagiellonian University Medical College, Department of Adult
Human beings are complex and cannot always be reduced to graphs Psychiatry, Kraków, Poland; 2 Institute of Zoology and Biomedical
and tables. Qualitative research can assist in painting a pallet of the Research, Jagiellonian University, Department of Neuroanatomy,
diverse human experience of psychiatric syndromes and ultimately Kraków, Poland; 3 Jagiellonian University Medical College,
assist clinicians to improve individualized patient care. Department of Affective Disorders, Kraków, Poland
interest statement.
Background and aims.– Cluster analysis is a useful tool for identify-
ing specific subgroups of a given disorder or subclinical states such
as schizotypy and bipolar spectrum. This allows us to better under-
stand the studied phenomenon and determine the phenotypes in
which the studied characteristics are arranged. In this study, we
focus on the above spectra in the context of the chronotype. We
aim to evaluate the association between bipolar and schizotypy E-PP1028

spectrum symptoms and circadian preferences with the use of the Text mining unstructured clinical data
cluster analysis.
routinely collected from a cohort of
Methods.– The study was based on an online survey. As a part
of the study, 1449 participants were recruited with an age
patients with serious mental disorder
span 18–35 years old. All participants completed self-report in South London
questionnaires: the Composite Scale of Morningness (CSM), the R. Wilson1* , E. Chukwusa1 , F. Gaughran2 , T. Whitburn3 , I.J.
Mood Disorder Questionnaire (MDQ), the Hypomania Checklist Higginson1 , W. Gao1
1 King’s College London, Cicely Saunders Institute, London, United
(HCL-32), the Oxford-Liverpool Inventory of Feelings and Expe-
riences (O-LIFE), the Munich ChronoType Questionnaire (MCTQ), Kingdom; 2 King’s College London, Institute of Psychiatry, Psychology
the Sleep Wake Pattern Assessment Questionnaire (SWPAQ), the and Neuroscience, London, United Kingdom; 3 Barts Health NHS
Temperament Evaluation of Memphis, Pisa, Paris and San Diego- Trust, Macmillan Palliative Care Team, London, United Kingdom
autoquestionnaire version (TEMPS-A). Statistical analysis was * Corresponding author.
performed using cluster analysis.
Background and aims.– Using routinely collected data, including
Results.– Clusters analysis identified 4 subgroups. The cluster 4 dif-
unstructured data in the form of clinical notes, in research can save
fers significantly from the other three, showing significantly higher
additional burden on patients and researchers’ time and resources,
values of morningnessand vigor. Cluster 4 has also significantly
by making use of already available data and avoiding primary data
lower scores on the MDQ scale and in the TEMPS-A and O-LIFE
collection. We aimed to explore the use of text-mining, specifi-
subscales. These differences are most marked in comparison with
cally using document term matrixes and word clouds, to identify
cluster 1, which significantly deviates from the CSM scale towards
words commonly reported in patients’ risk assessments, completed
eveningness.
in their clinical notes by mental health professionals. We compared
Conclusions.– To our knowledge, it is the first time cluster analy-
word frequencies across patients who died at home and in hospital.
sis was used to assess the coexistence of bipolar and schizotypy
Methods.– We used a linked dataset comprising mortality and clin-
spectrum and circadian preferences.
ical data from a cohort of deceased patients (between 2007–2015)
from South London with serious mental disorder. The text mining
interest statement.
package in R was used to construct document term matrixes, which
quantify the frequency of commonly-appearing words in free-text
E-PP1027 data. Word-clouds visualise the most commonly occurring words,
from patients’ clinical notes.
Tunisian cognitive battery for patients Results.– Linked mortality and risk assessment data were avail-
with schizophrenia able for N = 576 patients, of these, 192 died at home and 264 died
R. Trabelsi* , H. Ben Ammar, A. Kalifa, A. Aissa, Z. ElHechmi in hospital. Document term matrixes and word clouds show that
Razi Hospital, Psychiatry F, La Manouba, Tunisia the most commonly occurring words were generally the same for
* Corresponding author. patients who died at home and at hospital; “medication”, “alcohol”
and “(non-) compliance”.
Background and aims.– Cognitive disorders are common and severe
Conclusions.– Using text-mining techniques, we were able to illus-
in schizophrenia. They are also correlated with the functional
trate common words recorded in the clinical notes of patients who
outcome of the disease. Cognition can not be assessed during a
died. These techniques allow researchers to quantify and analyse
standard clinical interview but needs to be evaluated by means
unstructured data extracted from patients’ clinical records, demon-
of specific cognitive tasks. Aim of the study is to construct a bat-
strating a novel approach to using routine data to conduct research.
tery of cognitive tests which is adapted to the Tunisian cultural and
linguistic context and to collect normative data in Tunisian Arabic
interest statement.
speaking healthy subjects.
Methods.– We have selected and adapted cognitive tests to our socio
cultural context. Then we have proceeded to the administration of
these tests within a group of healthy subjects. E-Poster Presentation: Schizophrenia and other
Results.– The cognitive battery is composed of 8 tests: Cognitive
psychotic disorders - Part I
functions were evaluated with a batery of cognitive tests evaluat-
ing different cognitive domains. The memory was evaluated with
the Hopkins Verbal Learning Test (HVLT), the digit span task, and
the categorical semantic fluence test. For executive functions, we E-PP1029
used the phonemic speech fluency test, the TMT (TrailMaking Test), Theory of mind among sample of
the WCST (WisconsionCardSorting Test) and the Stroop test. Finally patients with non affective psychosis
attention was assessed by the Zazoo test and the Letter Digit Sub- M. Abdo1* , H. Mohamed Ezz Eldin Azzam2 , R. Hassan El Ghamry2 ,
stitution Test (LDST). These tests are presented with their manual R. Mohammed Nagiub2
of utilisation and their normative data. 1 Psychological Medicine Hospital, Psychiatry, Cairo, Egypt; 2 Ain
Conclusions.– The Tunisian cognitive battery is believed to permit a Shams University, Psychiatry, Cairo, Egypt
better cognitive assessment of patients suffering from schizophre- * Corresponding author.
nia. Improvement of cognitive impairments in schizophrenia is
associated with a better social and professional integration of these Background and aims.– Theory of Mind (ToM)deficits appear to be
patients. present across different stages of psychosis and may also charac-
Disclosure of interest.– The authors have not supplied a conflict of terize individuals at heightened risk for the development of this
interest statement. disorder. Aim is to compare ToM among a sample of patients with
acute psychosis to a sample with schizophrenia and normal con-
trols. Also correlate symptom profile and severity in the case groups
toToM.
Methods.– a case control study which was conducted on 20 patients
with acute psychosis, 40 patients with schizophrenia and 60 con-
trols at Psychiatry, Ain Shams University Hospitals. Patients were
diagnosed according to the Structured Clinical Interview for DSM- E-PP1031

IV Axis I Disorders (SCID-I), their severity of symptoms assessed by Estimation of influence
Scale for the Assessment of Positive Symptoms (SAPS), the Scale for
environmental pathoplastic factors on
the Assessment of Negative Symptoms (SANS), while controls were
assessed by General health questionnaire, furthermore all groups
the clinical manifestations of
were subjected to Reading the mind in the eyes (RMET). schizophrenia
Results.– The 2 case groups showed significantly higherToM deficits A. Sofronov1 , A. Dobrovolskaya1 , E. Abritalin1* , A. Trusova2 , A.
in comparison to the control group. Patients presenting with Alyokhin3 , V. Pashkovsky1 , S. Kolchev1 , F. Naumova1
1 North-Western State Medical University named after I.I. Mechnikov,
schizophrenia are significantly worse at RMETcompared to patients
with acute psychosis There is inverse correlation between duration Department of Psychiatry and Narcology, Saint-Petersburg, Russia; 2
of illness and ToM in Patients presenting with schizophrenia yet, St Petersburg University, Department of Medical Psychology and
age of onset has no significant correlation with TOM. In addition Psychophysiology, Saint-Petersburg, Russia; 3 Herzen State
severity of symptom profile in Patients with Acute psychosis, Neg- Pedagogical University, Department of Clinical Psychology,
ative symptoms is negatively correlated with ToM, while there is Saint-Petersburg, Russia
no significant correlation between positive symptoms and TOM. * Corresponding author.
In Patients with schizophrenia, Positive and Negative symptoms
Background and aims.– The representative sample includes 100
severity are negatively correlated withToM.
patients with paranoid schizophrenia (age 18-50 years, total score
Conclusions.– ToM deficits starts early in the disease process of
on the PANSS scale < 120, duration of mental disorders >5 years).
psychosis and worsens with longer disease duration and greater
Methods.– Clinical and socio-demographic characteristics of the
symptom severity,
patients have been analyzed, and the results were obtained
for the following scales: PANSS, BACS, WHOQOL, PSP, the
interest statement.
“Compliance Level” questionnaire, SOMO (Subjective Assess-
ment of Interpersonal Relations) test, “Emotional Intelligence”
E-PP1030 test and “Dembo-Rubinstein Self-Evaluation Test”. Characteristics
of patient’s nearest social environment (main caregivers) were
Epidemiological aspects of medical assessed by the FACES-3 and LSI scale.
care administration for patients with Results.– Statistical analysis methods allowed to obtain a countable
schizophrenia spectrum disorders indicator reflecting an integral index of patients’ quality of life and
during first five years of onset of social functioning, which was called “The Disease Burden Factor”
disease in Saint-Petersburg (Russia) (factor “B”). Factors obtained from the representative sample based
A. Sofronov, E. Abritalin* , A. Dobrovolskaya, O. Dudoladova on the FACES-3 and LSI scales found weak correlations with factor
North-Western State Medical University named after I.I. Mechnikov, “B”. Based on Bayes’ Theorem, significant links were established
Department of Psychiatry and Narcology, Saint-Petersburg, Russia between the PANSS indicators (positive and negative symptoms,
* Corresponding author. other symptoms), BACS (motor skills, verbal fluency, coding), the
duration of the disease since its manifestation, and the indicator of
Background and aims.– We studied socio-demographic profile factor “B”.
and pharmacoeconomic evaluation of psychopharmacologic treat- Conclusions.– Received data indicates the leading role of the specific
ments for patients with Schizophrenia Spectrum Disorders within symptoms, as well as impairment of communication functions,
first five years after onset of disease. planning skills, speed of thinking and motor skills in lowering the
Methods.– 1520 patients were used in the analyses: 54,8% – men, level of social functioning and quality of life of the patients. The
45,2% - women (mean age – 33,7 ± 10,1 years). constructed model did not confirm the influence of the nearest
Results.– The most frequently recorded of mental disorders was social environment indicators of patients on factor “B”. In the cur-
schizophrenia (80,6%), in which paranoid schizophrenia (71,5%) rent interpretation, factor “B” reflects the biological determinant
and simple schizophrenia (6,1%) were the most commonly diag- of social functioning and the quality of life of the patient.
nosed form of the disorder. Schizotypal disorder was diagnosed in Disclosure of interest.– The authors have not supplied a conflict of
8,4% of cases, schizoaffective disorder - in 7,7%; other disorders of interest statement.
the schizophrenia spectrum were less frequent (0,1–2,1%). Within
the last year before the survey, the average number of hospital-
izations was 0,52 ± 1,06, the average length of hospital treatment E-PP1032
was 30,6 ± 54,1 days. The study found that 34,1% of patients were Dopamine supersensitivity psychosis
employed or getting education. 28,9% of patients were disabled – criteria, prevention and treatment
and 33,8% were unemployed. The number of patients who were B. Almeida* , C. Fragoeiro, C. Machado, L. Monteiro, C. Fonseca
not (and had never been) married at the moment of examina- Hospital Magalhães Lemos, General Adult Psychiatry, Porto, Portugal
tion was 70,7%, 13,1% of patients lived alone, and 66,4% - with * Corresponding author.
parents. 85,3% of patients had antipsychotic pharmacotherapy, of
which 61,5% received just one antipsychotic drug, while 38,5% took Background and aims.– Neuroleptics are the standard treatment for
two or more antipsychotics (polypharmacy). Risperidone (21,9%) psychotic disorders. Despite their benefits, they also entail adverse
was the most frequently prescribed drug, followed by haloperidol events, namely dopamine supersensitivity psychosis (DSP). This
(18,4%) and olanzapine (16,2%). Additionally, antipsychotic drugs, clinical entity was first characterized by Chouinard and colleagues,
such as quetiapine (10.9%), paliperidone (10,7%), clozapine (8,9%), in 1978 - in the era of first-generation antipsychotics (AP). With
chlorprothixene (8,3%) and zuclopenthixol (7,4%) were also often this review we aim to investigate the current concept of DSP.
prescribed. Methods.– A literature review on Pubmed database was per-
Conclusions.– The obtained data will serve as a basis for the devel- formed using the terms “dopamine supersensitivity psychosis.” We
opment of treatment and rehabilitation programs for patients with selected the articles written in English, with free text available
schizophrenic spectrum disorders. which fulfilled the objectives exposed above.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The core features of DSP are: the presence of withdrawal
interest statement. or rebound psychosis after cessation, reduction or change of AP
(within six weeks for oral agents and three months for depot
injectable); tolerance to neuroleptics’ effect; and the presence or E-PP1034

history of tardive dyskinesia. The proposed mechanism for DSP is Are cardiovascular disease risk factors
upregulation and conversion to high affinity states of D2 receptors,
affected by antipsychotics in patients
after long-term AP treatment. To prevent DSP, clinicians should pre-
fer AP with longer half-life and smaller peak-to-trough fluctuations
with schizophrenia? What qrisk-3
and avoid high doses and high-potency AP, and monitor the appear- points?
ance of extra-pyramidal signs. Once DSP is established, treatment M. Aydın* , K. Altınbaş, H.T. Bozkurt
may be: add anticonvulsants; electroconvulsive therapy; switch Selcuk University, Psychiatry, Konya, Turkey
to clozapine, aripiprazol (with very slow titration) or to long act- * Corresponding author.
ing injectable risperidone. This is particularly important because
increasingly literature supports that DSP may be involved in the
Introduction.– The prevalence of cardiovascular disease (CVD) is
progression to treatment-resistant schizophrenia.
higher in patients with schizophrenia than in the general popula-
Conclusions.– DSP is both an old and new concept in psychiatry, still
tion. One of the explanations for increased cardiovascular events
controversial. More basic and clinical research will be fundamental
in schizophrenia is antipsychotics. Antipsychotics are known to
to better characterized DSP and its role in psychotic disorders.
increase metabolic syndrome risk, thereby increasing the risk of
CVD.
interest statement.
Objectives.– The aim of this study was to evaluate CVD risk of
patients and to investigate whether increase in cardiovascular risk
E-PP1033 in schizophrenia differs according to treatment as oral/depot or
typical/atypical antipsychotic forms.
Non-pharmacological interventions Methods.– The data were from patients who were consecutively
for the management of delusional admitted to Community Mental Health Center of Selcuk Univer-
disorder: a systematic and narrative sity between January 2018 and July 2018 with the diagnosis of
review schizophrenia. CVR was calculated using QRISK-3 risk calculator.
A. Alvarez1* , A. González Rodríguez2 , A. Guardia Delgado3 , N. Results.– A total of 67 (45 female, 19 male) schizophrenic
Sanz3 , F. Estrada3 , J.A. Monreal4 , D.J. Palao4 , J. Labad4 patients were included in this retrospective study. All patients
1 Corporació Sanitària Parc Taulí, Psychiatry Departament, Sabadell, were on antipsychotic medication (aripiprazole long-acting, n = 11;
Spain; 2 Corporació Sanitària Parc Taulí- I3PT- CIBERSAM, Mental haloperidol decanoate, n = 12; paliperidon palmitate, n = 23; cloza-
Health, Sabadell, Spain; 3 Corporació Sanitària Parc Taulí, Mental pine, n = 15; other oral antipsychotics, n = 6). Qrisk-3 was found
health, Sabadell, Spain; 4 Corporació Sanitària Parc Taulí- I3PT- to be significantly different between paliperidon palmitate and
CIBERSAM- UAB, Mental Health, Sabadell, Spain aripiprazole long-acting treatment groups, higher in the paliperi-
* Corresponding author. don palmitate group (mean rank, 19.83 vs 12.64; p = 0.048,
z = −1.973). Qrisk-3 was found to be significantly higher in haloperi-
Background and aims.– Delusional disorder has been traditionally dol decanoate group compared with the aripiprazole long-acting
considered a treatment resistant-disorder, and antipsychotics the group (mean rank, 15.17 vs 8.55; p = 0.019, z = −2.343). There were
treatment of choice. However, level of evidence for the pharmaco- no significant QRisk-3 ratio differences between the clozapine and
logical treatment of delusional disorder is low, and psychological paliperidon palmitate group (p > 0.05).
interventions have shown high level of evidence as coadjuvants to Conclusions.– As a result, elevation in Qrisk-3 ratio varies due
antipsychotics. to antipsychotic medication. CVD risk should be considered in
The main aim of this systematic review was to evaluate the effec- patients with schizophrenia. Qrisk-3 ratio may help while evalu-
tiveness of coadjuvant non-pharmacological interventions for the ating risk and prescibing antipsychotics.
treatment of patients with delusional disorder. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– A systematic computerized literature search was per- interest statement.
formed in Pubmed and Scopus databases (1980–September 2018),
according to the recommendations of the Preferred Reporting Items
for Systematic Reviews and Meta-Analyses (PRISMA) statement. E-PP1035
The following search terms were used: (treat* OR therap* OR cogn* Serum cortisol levels as a predictive
OR psychol*) and “delusional disorder”. Studies were only included
value of antipsychotic treatment
if they specifically reported findings for patients with delusional
disorder. response in patients with
Results.– A total of 2312 studies were identified: 1769 in Scopus and schizophrenia
543 in Pubmed, of which 5 met our inclusion criteria: Cognitive Z. Babinkostova* , B. Stefanovski, G. Kalpak
Behavioural Therapy (CBT) (n = 1), Cognitive Therapy (CT) (n = 2) University Clinic of Psychiatry, Biological psychiatry, Skopje, FYR
and Assertive Community Treatment (ACT) (n = 2). In brief, CBT Macedonia
demonstrated a higher effect on affect to belief and strenght of con- * Corresponding author.
viction compared to attention placebo control. CT was associated
with a marked reduction in belief conviction and improved adher-
Background.– Previous studies suggested that alterations in serum
ence with medications. ACT did not improve clinical symptoms,
cortisol and DHEA-S levels may play a role in the pathophysiology
but improved treatment adherence and functioning, in delusional
of schizophrenia.
disorder.
Imbalance in serum cortisol and DHEA-S levels may be related to
Conclusions.– CBT and CT may be the non-pharmacological inter-
responsivity to antipsychotic treatment.
ventions showing higher evidence in delusional disorder patients.
Aim.– To compare serum cortisol, DHEA-S levels and their ratio
High quality randomized trials on delusional disorder are still lack-
between patients with schizophrenia and healthy controls and to
ing.
evaluate their association with the response to antipsychotic treat-
ment.
interest statement.
Methods.– In this clinical prospective study were included 60
patients with schizophrenia and 40 healthy age and sex matched
control subjects. Clinical evaluation of patients was performed
using the Positive and Negative Symptom Scale. A questionnaire 1 Gedeon Richter Plc., Medical Division, Budapest, Hungary; 2
for socio-demographic and clinical data collection was used. For Allergan, Clinical Development, Madison, NJ, USA; 3 Allergan, Global
the purposes of the study, the examined group was divided in Medical Affairs, Madison, NJ, USA
two subgroups: responders and nonresponders. Serum cortisol and * Corresponding author.
DHEA-S levels were measured at baseline in all participants and
after 3 and 6 weeks of the antipsychotic treatment in patients with Background and aims.– The Positive and Negative Syndrome
schizophrenia. Scale (PANSS) is the most widely-used standardized instrument
Results.– Patients with schizophrenia had significantly higher for assessing symptom severity clinical trials of schizophrenia.
serum cortisol and DHEA-S levels in comparison to the control Research established the minimally clinically important difference
group. Responders had significantly higher serum cortisol and (MCID) for the total score of this scale, and results point to a ca.
DHEA-S levels compared with nonresponders. With logistic regres- 15–16 point change from baseline as being clinically relevant (using
sion analysis, only cortisol levels were found to be significant CGI as anchor). To date, no research exists addressing the MCID in
predictors of responsivity to antipsychotic treatment. negative symptom patients. The aim of the present study was to
Conclusions.– Elevated serum cortisol and DHEA-S levels may play establish the MCID on the PANSS-FSNS in schizophrenia patients
a role in the pathophysiology of schizophrenia. Higher serum with predominantly negative symptoms.
cortisol levels may have predictive value for positive response Methods.– Both, anchor-based and distribution-based methods
to antipsychotic treatment in patients with acute exacerbation were applied. Data from a large phase III trial, from 454 patients
schizophrenia. with predominantly negative symptoms was analyzed with 7 dif-
Disclosure of interest.– The authors have not supplied a conflict of ferent methods of calculating the MCID.
interest statement. Results.– Anchor based analyses estimated the cut-off value for
differentiation between no change and minimal clinical improve-
ment as 3 (ROC analysis), 3.8 (within patients score change) or
E-PP1036 2.2 (between patients score change) points improvement on the
Ekbom syndrome: a case report PANSS-FSNS versus baseline. Distribution based analyses estimated
J. Baek a 0.9 (standard error of measurement), 5.0 (limits of agreement),
Greater Manchester Metal Health NHS Trust, Psychiatry, Manchester, 0.5 (Cohens’ definition) or 1.5 (standardized response mean) point
United Kingdom improvement as MCID.
Conclusions.– Depending on the underlying concept, different
Background and aims.– Ekbom syndrome is a rare psychiatric disor- methods lead to different results for the MCID. Values range
der also known as delusional parastosis or delusional infestation. between 1 and 5 points change. Using the CGI as anchor, the results
The syndrome is characterised by the conviction of being infested are in line with the total PANSS based calculations, where a 7.1–7.6%
by invisible mites or insects, despite clear evidence of the contrary. change (15–16/210 points) is clinically important, which corre-
Traditionally, it is treated with antipsychotic Pimozide, however, sponds to a 3.4-3.7/49 points change on the FSNS versus baseline.
due to its side effects atypical antipsychotics could be considered Disclosure of interest.– The authors have not supplied a conflict of
as alternative option. interest statement.
Methods.– This is a case report of a typical example of primary delu-
sional parastosis. The patient is a 69 year old woman, who have
no previous psychiatric history and show a late onset of psychotic E-PP1038
symptoms without signs of cognitive impairment. About one year Functioning in schizophrenia from
ago she began feeling as if infested by worms and eggs after having the perspective of psychiatrists: a six
contact with her friend who was infected with scabies. She believed
who regions study
that her house and her body were infested with parasites and spent
M. Barrios1* , G. Guilera1 , E. Rojo2 , J. Gómez-Benito1 , L. Nuño3
most of day washing herself or cleaning house. Interestingly, there 1 University of Barcelona-Institute of Neurosciences, Faculty of
was also suspicion of her husband developing foil a deux and he
Psychology, Barcelona, Spain; 2 Hermanas hospitalarias, Benito
was echoing the patient’s behaviour and conviction of infection.
Menni CASM, Sant Boi de Llobregat, Spain; 3 Clinic Institute of
Results.– The difficulty was convincing the patient of the absence
Neurosciences, Hospital Clínic de Barcelona, Barcelona, Spain
of parasites and obtaining her consent for treatment. Following
liaison work with Dermatologist, the patient agreed to be treated
with antipsychotics. Risperidone was administered. The initial dose Background and aims.– Schizophrenia is a severe mental disorder
was 2 mg per day then increased to 4 mg per day after 2 weeks. associated with several functional impairments. The International
After about 6 weeks the patient showed improvement regarding Classification of Functioning, Disability and Health (ICF) Compre-
her delusion. hensive Core Set for schizophrenia (CS-SZ) is a shortlist of ICF
Conclusions.– This case report shows the efficacy of Risperidone in categories that are relevant for describing the functioning and dis-
primary delusional parastosis. In addition to drug therapy, estab- ability of persons suffering from schizophrenia. Aim: To assess the
lishing a therapeutic relationship was crucial. common aspects and the differences regarding the relevance of the
Disclosure of interest.– The authors have not supplied a conflict of CS-SZ categories among psychiatrists experienced in schizophrenia
interest statement. treatment that belong to the six World Health Organization (WHO)
regions (i.e. African, Americas, Eastern Mediterranean, European,
South East Asia and Western Pacific).
E-PP1037 Methods.– In a three-round survey using the Delphi technique, 352
What is the minimally clinically psychiatrists from 63 countries representing all six WHO regions
important difference in negative were asked about the problems they commonly encounter in
symptoms of schizophrenia? PANSS patients with schizophrenia. Their responses were linked to ICF
categories and those that reached consensus (≥75%) were selected.
based post hoc analyses of a phase III
Confidence intervals (95% CI) were conducted to identify differ-
clinical trial ences between experts from different WHO regions.
A. Barabassy1* , K. Acsai1 , I. Laszlovszky1 , B. Szatmári1 , J. Harsányi1 , Results.– One-hundred sixty-six second and third-level ICF cate-
B. Sebe1 , W. Earley2 , M. Patel3 , G. Németh1 gories and 31 personal factors were selected. A large number of
categories were common in all six WHO regions; however, signifi-
cant differences were found in the relevance of ICF categories from Background and aims.– Schizophrenia is a distressing and costly dis-
the component Activities and Participation, Environmental factors order, however, little is known about the societal impact in New
and Personal Factors. Zealand.
Conclusions.– These results suggest that although the ICF categories This study aimed to assess the prevalence and the health, social, and
from the CS-SZ are all accepted by psychiatrists from the differ- productivity impact of schizophrenia (SCZ) vs propensity matched
ent six WHO regions for describing functioning and disability in controls (controls) in the New Zealand population.
individuals with schizophrenia, it is observed that the relevance of Methods.– This was a retrospective analysis of routine New Zealand
some categories are higher in some WHO regions. government linked data. People with a diagnosis of SCZ through
Disclosure of interest.– The authors have not supplied a conflict of 2008 to 2015 were propensity score matched to controls (controls)
interest statement. on age, sex and ethnicity.
Results.– The 12-month prevalence for 2015 was 567 people per
100,000 population. Prevalence was higher for males, the indige-
E-PP1039 nous Māori population and Pacific Islander groups, and lower for
Long-term outcome of patients at females, Asian and European groups. There was a total of 1,100 peo-
clinical high risk (CHR) for psychosis ple with their first SCZ diagnosis in 2015 with a crude incidence rate
of 24.2 per 100,000. The crude mortality rate for people with SCZ
who do not transition to psychosis
was significantly higher compared to controls in all age groups. Peo-
K. Beck1* , E. Studerus1 , C. Andreou1 , A. Simon2 , L. Egloff3 , L.
ple with SCZ had significantly lower educational attainment, lower
Leanza1 , S. Borgwardt3 , A. Riecher-Rössler1
1 University of Basel Psychiatric Hospital, Center for Gender Research employment (22%), earned less income and lived in greater depri-
vation vs controls. The majority of people with SCZ (71%) received
and Early Detection, Basel, Switzerland; 2 Specialized Early Psychosis
income from social security benefits. Government costs were sig-
Outpatient Service for Adolescents and Young Adults, Department of
nificantly higher for the SCZ group than controls. People with SCZ
Psychiatry, Bruderholz, Switzerland; 3 University of Basel Psychiatric
were significantly more likely than PMC to come into contact with
Hospital, Department of Psychiatry, Basel, Switzerland
the criminal justice system.
Conclusions.– SCZ has a very significant social and economic burden
Background and aims.– We have reported on the late transitions that impacts individuals’ future employment and earning ability
to psychosis of patients at clinical high risk (CHR) (Beck et al., and incurs a substantial government financial cost.
2017). However, little is known about the long-term outcome of the Disclosure of interest.– The authors have not supplied a conflict of
approximately two thirds of CHR patients who do not develop psy- interest statement.
chosis (CHR-NT patients). We aimed to investigate the long-term
clinical and functional outcome of CHR-NT patients.
Methods.– All CHR-NT patients of the Fepsy and Bruderholz study E-PP1041
were contacted for long-term follow-up regarding remission from Analysis of evolution and attitude to
CHR (BPRS), axis I diagnoses (SKID-I for DSM-IV), functional out- medication and in schizophrenic
come (Personal and Social Performance Scale), and full clinical and sample during two years of treatment
functional recovery. Baseline predictors included age, gender, posi-
with aripiprazole once-monthly
tive and negative symptoms, psychosocial functioning and current
A. Benito1* , G. Lahera2 , M. Soto3
cannabis use. Remission from CHR was defined as the absence 1 Hospital Provincial de Toledo, Psichiatry, Toledo, Spain; 2 Alcala de
of (subclinical) psychotic symptoms for at least 12 consecutive
Henares University, Psychiatry, Madrid, Spain; 3 Hospital Provincial
months.
de Toledo, Psychiatry, Toledo, Spain
Results.– Sixty of the CHR-NT patients were evaluated (follow-up
duration 8.2 ± 4.4; 0.1–16.6 years). Nine of them (15%) continued to
experience attenuated psychotic symptoms, 21 (35%) had at least Background and aims.–
one current axis I diagnosis, 29 (48.3%) exhibited poor functional Background.– Non adherente is a mayor problem in the treatment
outcome, and only 17 (28.3%) showed full clinical and functional of schizophrenia. Publishes reports confirm the significant contri-
recovery at long-term follow-up. Higher age and less negative bution of attitudes towards treatment and its impact on adherence
symptoms at baseline were associated with better functional out- and clinical outcomes.
come at a trend level of statistical significance (p = 0.06 and p = 0.09). Aims.– To assess the clinical evolution and attitudes towards medi-
No significant predictors emerged for remission from CHR. cation in a sample of patients diagnosed with schizophrenia during
Conclusions.– Even though they do not progress to frank psychosis, one year of treatment with aripiprazole once-monthly (AoM).
most CHR-NT patients seem to continue to experience clinical Methods.– The sample included a total of 36 outpatients
symptoms and/or functional impairments even many years after schizophrenic patients. Inclusion criteria were an age over 18 and
initial identification and need adequate clinical attention. 35 years, a diagnosis of schizophrenia (ICD-10 criteria), the start
Disclosure of interest.– The authors have not supplied a conflict of of treatment with AoM. A series of demographic variables were
interest statement. recorded, the DAI-10 (Drugs Attitude Inventary) scale was used to
evaluate the attitudes to medication, PANSS scale was used to to
identify the presence and severity of psychopathology symptoms,
E-PP1040 the CGI scale was used to assesses the severity of th symptoms, also
Prevalence, social and economic analyzed time to relapse. The scales were again applied at baseline,
impact of schizophrenia in the New 6, 12, and 18 months after the start of treatment.
Zealand population Results.– N = 36 patients (22 males and 14 females), mean age of 32
J. Bell1* , S. Gibb2 , N. Brewer2 , A. Puig3 years. 2 dropouts during follow-up. Results showed an improve-
1 Janssen-Cilag Pty Ltd, Business Development, Auckland, New ment in PANSS and CGI score during the 18 months, manifesting
Zealand; 2 University of Otago, School of Public Health, Wellington, from the sixth month (ANOVA, p < 0.05). Likewise, statistically sig-
New Zealand; 3 Janssen-Cilag Pty Ltd, Health Economics & Outcomes nificant differences (ANOVA, p < 0.05) were observed with the DAI
Research, Sydney, Australia scale.
* Corresponding author. Conclusions.– In our sample of patients diagnosed with schizophre-
nia during 18 months of treatment with AoM results of the study
shows an improved attitude to the medication, functioning and Aim.– To find the prevalence of IgM and IgG antibodies among
prevention of relapse. patients diagnosed with psychotic disorders and to find the asso-
Disclosure of interest.– The authors have not supplied a conflict of ciation between Toxoplasma Gondii infection and psychosis.
interest statement. Methods.– In this cross-sectional hospital-based study, 33 patients
diagnosed with Schizophrenia (18.2%), Acute and Transient Psy-
chotic Disorder (ATPD) (13%), Bipolar Disorder BPD) (9.1%) and
E-PP1042 Cannabis Induced Psychosis (CIP) (2.6%) along with 28 first degree
Help seeking behaviour, untreated relative (FDR) and 16 healthy controls were examined for the pres-
illness and duration of untreated ence of both IgM and IgG antibodies against T. gondii using the
Enzyme-Linked Fluorescent Assay (ELFA) in the mini VIDAS system
psychosis amongst first time
(BioMérieux).
psychosis patients in urban and rural Results.– The positivity rate for anti-T. gondii IgG antibodies among
regions in Latvia patients with the psychotic disorder (33.3%) was higher than the
L. Berze1* , K. Mieze2 , K. Bruna2 , K. Slikova2 , J. Zaharova2 , S. FDR (14.3%) and control (6.2%). 28.6% of schizophrenia, 40% of ATPD
Kikuste3 , I. Sapele3 , E. Rancans2 and 50% of CIP were positive for the IgG. No statistically significant
1 Riga Stradins University, Department of Doctoral Studies, Riga,
association was found between the diagnosis and seropositivity.
Latvia; 2 Riga Stradins University, Department of Psychiatry and Conclusions.– Further investigation with adequate sample is needed
Addiction Disorders, Riga, Latvia; 3 Daugavpils Psychoneurological to establish the probable causal association between T. gondii and
Hospital, Department of Mental Health Care, Daugavpils, Latvia psychotic disorder among the Indian population.
interest statement.
Background and aims.– Geography, which could possibly define
socioeconomic environment, has an impact on service ability and
therefore influences pathways to help seeking and delay of start- E-PP1044
ing treatment (Kvig et al., 2017). Aim: Evaluate differences between
Chronic catatonia resulting into
two FEP patients’ cohorts in urban and rural regions in Latvia.
Methods.– All consecutive patients with FEP (n = 207) were inter- contracture, treated with high dose
viewed in two hospitals: Rigas Centre of psychiatry and addiction Lorazepam-a case report
medicine (n = 113), time period 01.07.2017.–01.07.2018., and Dau- S. Bhattacharya1* , S. Chatterjee Sekhar2 , S. Mitra3 , D. Khongla2
1 Derbyshire Healthcare NHS foundation Trusti, Psychiatry,
gavpils Psychoneurological hospital in rural region (n = 94), period
01.01.2016.–31.12.2017. ICD-10 criteria for schizophrenia spec- Chesterfield, United Kingdom; 2 DH Medical College and
trum disorder was used, authors conducted structured interviews Hospital-India, Psychiatry, Kolkata, India; 3 Rockhampton Base
including sociodemographic data and clinical characteristics. The hospital, Psychiatry, Queensland, Australia
study was approved by the RSU Ethics committee. * Corresponding author.
Results.– From all 113 consecutive FEP patients in Riga 68 (1st
group) met the inclusion criteria; from 94 FEP in Daugavpils we Background and aims.– Catatonia is an intriguing entity in Psychia-
included 77 (2nd group). There were 42 men (61,7%) in the 1st try with high morbidity and mortality that might lead to substantial
group, median age 29 y. (IQR 24,0–38,5), and 44 men (57,1%) in the complication if left untreated. Chronic sequelae of catatonia is
2nd group: median age 33 y. (IQR 27,0–43,0), p = 0,067. DUP in the exceedingly rare. We hereby report this case to show that catatonia
1st group was 4 weeks (IQR 2.0–16.0) vs 4 weeks (IQR 1.0–12.00) can be severe enough to cause even contracture.
in the 2nd group, and DUI was 144 weeks (IQR 24.0–240.0) vs 96 Methods.– 36 year old lady came with reports of chronic posturing
weeks (IQR 24.0–192.0), p > 0,05, respectively. Self-initiated visit of and refusal to eat for 6 months. She was non-concordant with her
psychiatric ER in 1st group 5,8% vs 11,9% in 2nd group, relatives medication due to poor insight. She went missing for 2 years and
initiated- 44,1% vs. 74,0% and medical workers initiated- 27,9% vs was found by her family members in a dishevelled condition with
10.3%, p = 0,000. posturing, muteness, and refusal of food and drink. Her left leg and
Conclusions.– Significant differences in help seeking behaviour right hand had contractures. She was admitted to inpatient unit
between patients in city and rural region were found. No significant and managed collaboratively with medical team.
differences in DUP or DUI was found between these regions. She was treated starting with iv lorazepam and then oral along with
Disclosure of interest.– The authors have not supplied a conflict of Clozapine. After 3 weeks, a gradual discontinuation of Lorazepam
interest statement. was attempted, which led to a relapse of her symptoms and pos-
tures. She was restarted Lorazepam and discharged. She was not
administered ECT since her physical health was not conducive for
E-PP1043 anaesthesia.
Results.– She was maintaining well at 4 months follow-up. She was
Relationship between toxoplasma
also linked with the physical rehabilitation unit for the contrac-
gondii and psychotic disorders with tures, which had improved as well with conservative interventions.
implications toward a brain-based Conclusions.– Our case demonstrates that posturing in chronic cata-
diagnostic system: a pilot study report tonia may be severe enough to cause deformity of joints. Our case is
S. Bhandari MD1* , D. Raja2 , C. Phukan2 , S. Das3 , S. Talukdar3 also relevant in demonstrating that long term high dose Lorazepam,
1 Sikkim Manipal Institute of Medical Sciences, Department of coupled with Clozapine for primary Schizophrenia, has a beneficial
Psychiatry, Gangtok, India; 2 Gauhati Medical College and Hospital, effect on long standing catatonia, and can aide in physical rehabil-
Department of Microbiology, Guwahati, India; 3 Gauhati Medical itation of the patient.
College and Hospital, Department of Psychiatry, Guwahati, India Disclosure of interest.– The authors have not supplied a conflict of

Background.– People with mental illness specially with the psy-
chotic disorder spectrum have been found to have a high
seropositivity for Toxoplasma Gondii infection.
E-PP1045 Background and aims.– According to previous literature, language

Associations of polymorphic variants abilities, attention and processing speed are often emphasized as
of muscarinic, glutamatergic and the most impaired among different domains of neurocognitive
functioning in schizophrenia. Our aim was to investigate the course
adrenergic receptors genes and of changes in these neurocognitive functions in patients with first-
tardive dyskinesia in schizophrenia episode psychosis (FEP) during an 18-month follow-up.
A.S. Boiko1* , S.A. Ivanova1 , A.J.M. Loonen2 Methods.– This study is a part of the prospective cohort
1 Mental Health Research Institute Tomsk National Medical Research study: “Biomarkers in schizophrenia-integration of complemen-
Centre of RAS, Laboratory of Molecular Genetics and Biochemistry, tary methods in longitudinal follow up of FEP”. We recruited 159
Tomsk, Russia; 2 University of Groningen, Unit PharmacoTherapy, FEP at the acute phase of illness during their first hospital treatment
Epidemiology & Economics, Groningen Research Institute of at two Croatian psychiatric clinics. Patients were assessed with
Pharmacy, Groningen, The Netherlands sociodemographic questionnaire, Positive and Negative Syndrome
* Corresponding author. Scale and neurocognitive tests for language abilities (Phonetic and
Semantic Fluency Test), attention and processing speed (Stroop
Background and aims.– Tardive dyskinesia (TD) is a side effect of
Test, Trial Making Test A, Digit Symbol Test) at two time points:
antipsychotic treatment. Certain role belongs to genetic factors that
during the first-episode of illness and after 18 months of follow-up.
might serve as the basis of sensitivity to development of TD.
Results.– As 30 patients (19%) were lost to follow-up, we analyzed
The aim is to determine possible associations between genes
129 patients. Relative improvement rates in particular tests for
of muscarinic (CHRM1, CHRM2, CHRM4), glutamatergic (GRIK4,
attention and processing speed ranged from 11% to 19%, and for
GRIN2A) and adrenergic receptors (ADRˇ1, ADRA1A) and TD in
language abilities were 7% for Phonetic and 8% for Semantic Fluency
patients with schizophrenia.
test. Results were statistically significant for all tests and subtests
Methods.– In total 449 patients with schizophrenia were included in
besides Phonetic Fluency (p = 0.311).
the study: 121 patients with TD and 328 patients without it. Deter-
Conclusions.– Although there was a slight improvement in language
mination of a set of 22 polymorphisms of CHRM1, CHRM2, CHRM4,
abilities after 18-months follow-up, it seems that impairment of
1 polymorphism of GRIK4, 3 polymorphisms of GRIN2A, 1 polymor-
these abilities needs more time to recover or that it remains rela-
pism of ADRˇ1 and 2 polymorphisms of ADRA1A was performed by
tively stable trait during the course of illness.
PCR-RT.
Results.– A significant decrease in the frequency of GG geno-
interest statement.
type (rs1824024) of gene CHRM2 was found in patients with
TD (2 = 6.161, p = 0.046). This genotype carries a protective
effect on TD (OR = 0.4, 95%CI: 0.19–0.88). The frequency of T E-PP1047
allele (rs2061174) was significantly higher in patients with TD
(2 = 6.027, p = 0.04) and it has predisposing effect on the develop-
Obesity in individuals with
ment of TD (OR = 1.38, 95%CI: 1.1–1.9). Also we found an increase schizophrenia: a case-control study in
in the frequency of AA genotype (rs2036108) of gene ADRA1A in South Tunisia
patients with TD (2 = 8.055, p = 0,018) and it has predisposing R. Boukhchina1* , L. Ghanmi1 , M. Romdhan2 , N. Rezig2 , M. Abbes1 ,
effect (OR1 = 4.11, 95%CI: 1.28–13.22). K. Zitoun1 , H. Denguir3
1 Regional Hospital of Gabès, Psychiatry department, Gabès, Tunisia;
Conclusions.– This study identified associations between CHRM2
2 Regional Hospital of Gabès, Laboratory of Medical Analysis, Gabès,
and ADRA1A variations and TD. Reduction or increasing of the fre-
quency of some genotypes in patients with TD demonstrated the Tunisia; 3 Regional Hospital of Gabès, Department of Cardiology,
protective or predisposing effect of these genotypes regarding risk Gabès, Tunisia
of TD. This work is supported by RSF grant 17-75-1005. * Corresponding author.
interest statement. Background and aims.– Schizophrenia has been associated with sev-
eral health concerns and risks. There is a growing concern that
patients with schizophrenia may also be at risk for being over-
weight or obese, compared with the general population.
E-Poster Presentation: Schizophrenia and other Aims.– To estimate the prevalence of obesity in patients with
psychotic disorders - Part II schizophrenia and to compare them with matched controls.
Methods.– A cross-sectional case-control study conducted in the
Psychiatric Department of the Regional Hospital of Gabès. It
included a group of 88 patients meeting the schizophrenia diag-
E-PP1046
nostic criteria of DSM-IV and a comparing group of 63 healthy
Changes in language abilities, controls recruited from the stomatology department of the same
attention and processing speed in hospital. The collection of socio-demographic and clinical data was
patients with first-episode psychosis done using a pre-established questionnaire. We calculated BMI
after 18-month follow-up (Kg/m2 )and waist circumferences for each subject. Subjects were
D. Bosnjak Kuharic1* , P. Makaric2 , I. Kekin3 , T. Sabo2 , Z. Bajic4 , A. classified as obese (BMI ≥ 30 kg/m2 ) or not obese (BMI < 30 kg/m2 ).
Savic1 , A. Silic1 , D. Ostojic1 , P. Brecic2 , V. Jukic5 , M. Rojnic Results.– The majority of patients were male (68%), with a mean
Kuzman3 age of 46,8 years. The average BMI in the group of patients was
1 University Psychiatric Hospital Vrapce, Department for Diagnostics 26,3 versus 25,9 in the control group with no significant difference
and Intensive Care, Zagreb, Croatia; 2 University Psychiatric Hospital between the two groups. Obesity was significantly linked to female
Vrapce, Department for Affective Disorders, Zagreb, Croatia; 3 Clinical gender (46,4 vs. 8,3%; p < 10−3 ). The prevalence of obesity (BMI > 30)
Hospital Centre Zagreb, Department for Psychiatry, Zagreb, Croatia; 4 in this sample was 20,5%, nearly 2 times the prevalence of obesity
Biometrika Healthcare Research, Biometrika Healthcare Research, in the control group (9,5%) but this difference was not statistically
Zagreb, Croatia; 5 University Psychiatric Hospital Vrapce, significant.
Department for Forensic Psychiatry, Zagreb, Croatia Conclusions.– People with schizophrenia are at increased risk of
* Corresponding author. being obese compared with controls matched by age, gender and
practice attended. Priority should be given to research which aims
to reduce weight and increase activity in those with schizophrenia.
Disclosure of interest.– The authors have not supplied a conflict of psychosis (FEP), specifically young patients, through mobile
interest statement. app–based interventions.
The aim of this study is to develop and test the effectiveness of a
mobile app–based intervention to improve community functioning
E-PP1048 in adolescents with FEP.
Prevalence of metabolic syndrome in Methods.– We developed an Android and IPhone Mobile app
Tunisian patient with schizophrenia for patients with adelescents with FEP recruited from Gregorio
R. Boukhchina1* , L. Ghanmi1 , N. Rezig2 , M. Romdhan2 , M. Abbes1 , Marañón Hospital, with a web support and administration applica-
K. Zitoun1 , H. Denguir3 tion which registered interactions between the users and the app
1 Regional Hospital of Gabès, Psychiatry department, Gabès, Tunisia; in order to generate relevant data and key performance indicators
2 Regional Hospital of Gabès, Laboratory of medical analysis, Gabès, and thus support a wide range of further analyses.
Tunisia; 3 Regional Hospital of Gabès, Cardiology Department, Gabès, Results.– The app is composed of 5 modules: (1) Psychoeduca-
Tunisia tional: focuses on improving patients’ insight into their illness,
* Corresponding author. adherence, detection and identification of prodromes... In order
to facilitate integration, psychoeducation will be administered
Background and aims.– The patients with schizophrenia constitute through animated videos (2) recognition of symptoms and preven-
a population at risk of developing metabolic syndrome and car- tion of relapses: It has an alert system by which patients can weekly
diovascular complications. We aimed to determine the prevalence check their symptoms, cognitive performance, and emotional and
of metabolic syndrome among patients with schizophrenia and behavioural circumstances. (3) Problem-solving: the participants
the risk factors associated with it. We also aimed to compare this can share their problems and ask other participants to provide
prevalence to those of a control group and a group of first-degree possible solutions. (4) Mindfulness: adolescents can hear audio
relatives. recordings with techniques like body. (5) Contact wall: Patients
Methods.– A cross-sectional case-control study conducted in our can use the wall to share their interests and experiences.
Psychiatric Department for a period of 12 months. It was about Conclusions.– This is an innovative study that develop a psycholog-
88 patients meeting the schizophrenia diagnostic criteria of DSM- ical intervention through a mobile app for patients with FEP during
IV. This group was compared to two other groups: one consisting the critical period. The study could make treatment available to a
of 31 healthy relatives; and the other consisting of 63 healthy much larger population in their communities and even in their own
controls recruited from the stomatology department of the same homes.
hospital. All three groups were matched by age and gender. The Disclosure of interest.– The authors have not supplied a conflict of
socio-demographic and clinical data were collected using a pre- interest statement.
established questionnaire. The biological dosages were practiced
on blood samples after 12 hours of fasting. The metabolic syndrome
was evaluated according to the National Cholesterol Education Pro- E-PP1050
gram Adult Treatment Protocol (NCEP ATPIII) criteria. Characterizing acyl-carnitine
Results.– The prevalence of MS in patient group was 30.7% com- biosignatures for schizophrenia: a
pared to 19.4% and 20.6% in the parent and the control group
longitudinal pre- and post-treatment
respectively, with no significant difference between them. In
the univariate study, the factors associated with MS were:High study
socio-economic status (p = 0,016), couple life (p = 0,03)and the B. Cao1* , D. Wang1 , Z. Pan2 , E. Brietzke2 , R. McIntyre2 , J. Wang1
1 Peking University, School of Public Health, Beijing, China; 2 Toronto
total duration of antipsychotics intake (p = 0,037). After multivari-
ate logistic regression analysis, factors associated with the MS Western Hospital, University Health Network, Mood Disorders
were high socioeconomic status (OR = 3,88;IC 95% [1,14–13,2]), the Psychopharmacology Unit, Toronto, Canada
couple life (OR = 4,9;IC 95% [1,53–15,6]), and smoking cigarettes * Corresponding author.
(OR = 0,27;IC 95% [0,08–0,86]).
Background and aims.– Subjects with schizophrenia have high risks
Conclusions.– Metabolic syndrome is frequent in patients with
of metabolic abnormalities and bioenergetic dysfunction. Acyl-
schizophrenia. It is associated with long-term exposure to AP. It
carnitines involved in bioenergetic pathways provide potential
is essential to ensure an adequate therapeutic choice for them.
biomarker targets for identifying early changes and onset charac-
teristics in subjects with schizophrenia.
interest statement.
Methods.– We measured 29 acyl-carnitine levels within well-
characterized plasma samples of adults with schizophrenia and
healthy controls using liquid chromatography-mass spectrometry
E-PP1049
(LC-MS). Subjects with schizophrenia were measured at base-
A mobile app–based intervention for line and after 8 weeks of treatment. A total of 225 subjects with
adolescents with first-episode schizophrenia and 175 age- and gender-matched healthy controls
psychosis: the think app were enrolled and 156 subjects completed the 8-week follow-up.
A. Calvo1* , T. Sánchez-Gutiérrez1 , S. Barbeito1 , M. Mayoral2 , M. Results.– With respect to plasma acyl-carnitines, the individuals
Moreno3 , S. Ríos- Aguilar4 , C. Arango2 with schizophrenia at baseline showed significantly higher levels of
1 Universidad Internacional de La Rioja, Faculty of Health Sciences, C4-OH (C3-DC) and C16:1, but lower concentrations of C3, C8, C10,
Madrid, Spain; 2 Hospital General Universitario Gregorio Marañón C10:1, C10:2, C12, C14:1-OH, C14:2 and C14:2-OH when compared
School of Medicine, Universidad Complutense, IiSGM, CIBERSAM. with healthy controls after controlling for age, sex, body mass index
Madrid, Spain, Department of Child and Adolescent Psychiatry, (BMI), smoking and drinking. For the comparison between pre-
Madrid, Spain; 3 Mental Health Network of Guipuzcoa, Biodonostia, treatment and posttreatment subjects, all detected acyl-carnitines
Department of Child and Adolescent Psychiatry, San Sebastian, Spain; were significantly different between the two groups. Only the con-
4 Universidad Internacional de LA Rioja, School of Engineering and centration of C3 and C4 were increased after selection by variable
Technology, Madrid, Spain importance in projection (VIP) value > 1.0 and false discovery rate
* Corresponding author. (FDR) q value < 0.05. A panel of acyl-carnitines were selected for
the ability to differentiate subjects of schizophrenia at baseline
Background and aims.– Previous studies have shown an improve-
ment in the access to treatment for patients with first-episode
from controls, pre- from post-treatment, and post-treatment from Methods.– A total of 100 consecutive schizophrenia outpatients,
controls. with primary negative symptoms, were evaluated using the
Conclusions.– Our data implicated acyl-carnitines with abnor- Positive and Negative Syndrome Scale (PANSS), Negative Symp-
malities in cellular bioenergetics of schizophrenia. Therefore, toms Assessment Scale (NSA-16), Calgary Depression Scale for
acyl-carnitines can be potential targets for future investigations Schizophrenia (CDSS), Simpson-Angus Scale (SAS) and a semi-
into their roles in the pathoetiology of schizophrenia. structured interview was used to assess demographic features and
Disclosure of interest.– The authors have not supplied a conflict of body mass index. Data were analyzed using descriptive statistics,
interest statement. principal component analysis, correlation analysis and analyses of
variance and co-variance.
Results.– We found a two-factor solution for the negative symptoms
E-PP1051 of schizophrenia represented by AA and DE. Analyses of correlation,
Comparison of serum alkali metals variance and co-variance suggested that higher AA scores were
and alkaline-earth metals between associated with normal weight. No significant differences were
found regarding DE scores in relationship with the body mass index.
patients with schizophrenia and
Conclusions.– Our findings suggest the AA and DE domains show
healthy controls meaningful differences concerning the relationship with body mass
B. Cao1* , Y. Chen2 , L. Yan1 , R. McIntyre2 , J. Wang1 index. Lower apathy-avolition levels are associated with higher
1 Peking University, School of Public Health, Beijing, China; 2 body mass index in chronic stable schizophrenia patients.
University Health Network, Mood Disorders Psychopharmacology Disclosure of interest.– The authors have not supplied a conflict of
Unit, Toronto, Canada interest statement.
Background and aims.– Alkali metals (AMs) and alkali-earth met-

E-PP1053
als (AEMs) affect levels and signalling of neurotransmitters, which
potentially play a role in the etiology of neurodevelopment dis- Secondary negative symptoms in
orders, including schizophrenia (SCZ). Herein, we performed a schizophrenia
case-control study to explore the associations between serum con- O. Capatina1* , B. Androne2 , M. Fadgyas Stanculete2
1 Iuliu Hatieganu University of Medicine and Pharmacy, Neurosience,
centrations of four AMs [i.e. potassium (K), sodium (Na), rubidium
(Rb), cesium (Cs)], four AEMs [i.e. magnesium (Mg), calcium (Ca), Cluj-Napoca, Romania; 2 Iuliu Hatieganu University of Medicine and
strontium (Sr), barium (Ba)], and SCZ. Pharmacy, Neuroscience, Cluj-Napoca, Romania
Methods.– We recruited 105 inpatients diagnosed with SCZ by DSM- * Corresponding author.
IV, who had not received pharmacological treatment for at least one
month prior to enrollment, and 106 age and sex matched healthy Background and aims.– Negative symptoms of schizophrenia are
controls (HCs) from Weifang, China. Serum concentrations of Na, K, considered to be a core feature of the disease and the current
Ca, Mg were evaluated by inductively coupled plasma-atomic emis- conceptualization of these symptoms classifies them as primary
sion spectrometry (ICP-AES), while Rb, Cs, Sr, Ba were evaluated by or secondary. The distinction between primary and secondary
inductively coupled plasma-mass spectrometry (ICP-MS). negative symptoms is causal. Primary negative symptoms are con-
Results.– Serum concentrations of two AEMs (Mg and Sr) were sig- sidered to be intrinsic to the disease, while secondary negative
nificantly elevated in the SCZ group, compared to HCs (20.86 vs. symptoms are thought to be caused by different underlying mech-
19.73 ␮g/mL of Mg, P < 0.001; 53.14 vs. 42.26 ng/mL of Sr, P < 0.001), anisms: positive symptoms, medication side-effects, depression or
which remained statistically significant for the dichotomized social deprivation. At a phenomenological level primary and sec-
data after adjusting for potential confounders (Mg: OR = 2.538, ondary negative are similar and very hard to distinguish. Most
95%CI: (1.254, 5.136), P = 0.010; Sr: OR = 3.798, 95%CI: (1.769,8.153), research in this area focuses on primary negative symptoms aim-
P = 0.001). No significant differences were observed for all four ing to rule out secondary negative symptoms which are most of the
selected AMs (i.e. Na, K, Rb, Cs) or two AEMs (Ca and Ba) between times a subsidiary outcome measure.
SCZ and HCs. Methods.– In this literature review we summarized the most com-
Conclusions.– Higher Mg and Sr serum concentrations were associ- mon mechanisms underlying secondary negative symptoms and
ated with SCZ in a Chinese population. Future studies will be needed the developments in the conceptualization, assessment and treat-
to determine the potential mechanisms involved, which may yield ment for this category of symptoms.
insights into the pathogenesis of SCZ with potential implications Results.– Factorial analyses showed that secondary negative symp-
for future treatments, protective and preventative strategies. toms encompass the same domains as primary negative symptoms:
Disclosure of interest.– The authors have not supplied a conflict of avolition/apathy and diminished expression, but it is not yet clear
interest statement. and evidence are sparse regarding how specific causes of secondary
negative symptoms are related which negative symptom domain.
Even though recent research defined the main causes of secondary
E-PP1052 negative symptoms evidence based treatment recommendations
remained scattered.
Negative symptoms and body mass
Conclusions.– Secondary negative symptoms haven’t been the the
index in the chronic phase of primary focus of research on negative symptoms. The underly-
schizophrenia ing mechanisms of these symptoms are still poorly understood,
O. Capatina* , I. Miclutia, M. Fadgyas Stanculete but given the overlapping phenomenology with primary negative
Iuliu Hatieganu University of Medicine and Pharmacy, Neuroscience, symptoms some common pathophysiology could be found.
Cluj-Napoca, Romania Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– Our study aimed to validate the hypothesis
that negative symptoms of schizophrenia encompass two domains
namely apathy-avolition (AA) and diminished expression (DE) and
to investigate the relationship of these domains with body mass
index.
E-PP1054 He was anguished. He complained of stomachache and believed he

Sinus bradycardia secondary to was pregnant. He wanted to shoot his abdomen in order to kill the
treatment with paliperidone baby. He did not present any clinical symptoms of hyperprolactine-
mia. First he was treated by antipsychotic. Given the persistence of
palmitate injection suicidal thoughts and sadness, we prescribed fluoxetine. After 2
C.M. Capella Meseguer1* , G. Medina Ojeda1 , E.M. Rodríguez
weeks, he showed an improvement. Thus, he was discharged from
Vázquez1 , N. de Uribe Viloria1 , M. de Lorenzo Calzón1 , M. Gómez
the hospital. At the one month follow-up, the patient had neither
García1 , A. Alonso Sánchez1 , A. Álvarez Astorga1 , H. Red Gallego1 ,
psychotic symptoms nor abnormal behavior. He almost reached
J.I. Gonçalves Cerejeira1 , I.D.L.M. Santos Carrasco1 , R. Hernández
his pre-morbid level of functioning. However, Mr. R.K felt embar-
Antón1 , M. Iglesias Tejedor2
1 Clinical Universitary Hospital of Valladolid, Psychiatry, Valladolid,
rassed to talk about his pregnancy delusion and had difficulties to
deal with stigma.
Spain; 2 Clinical Universitary Hospital of Valladolid, Neurophysiology,
Conclusions.– Pregnancy delusion in men is a challenge for clini-
Valladolid, Spain
cians. In addition to treating it, doctors have to check whether their
patients have clinical signs of hyperprolactinemia and help them
Background and aims.– Paliperidone palmitate is an antipsychotic, cope with the difficulties they might face afterwards.
active metabolite of risperidone, unlike traditional neuroleptics Disclosure of interest.– The authors have not supplied a conflict of
besides being blocking dopaminergic D2 antagonist is selective interest statement.
serotoninergic 5-HT2 receptors. It also antagonizes alpha1 adren-
ergic receptors and, in lesser way, also histaminergic H1 and alpha2
E-PP1056
adrenergic receptors. The most frequently reported adverse reac-
tions due to its use are headache, sinus tachycardia, pyramidal Clinicaland functional outcomes of
disorders and akathisia. long-acting antipsychotic injections in
It is presented the case of a 48 year old male patient, a non- stable schizophrenia patients: a 1-year
smoker with no other cardiovascular risk factors, diagnosed with follow-up study
Paranoid Schizophrenia in 2011 was in psychopharmacological V. Corigliano1* , A. Comparelli1 , A. Nardella1 , G. Falcone1 , I.
treatment with paliperidone palmitate 350 mg injection quarterly Mancinelli1 , A. De Carolis2 , D. Erbuto1 , M. Pompili1
and lorazepam 1 mg (0-0-1) in which the appearance of a sinus 1 Sapienza University of Rome, Italy, NESMOS Department
bradycardia is observed that after suspension of antipsychotic Neurosciences, Mental Health and Sense Organs Unit of Psychiatry,
treatment with paliperidone and substitution by aripiprazole Sant’Andrea Hospital, School of Medicine and Psychology, Rome,
reverts. Italy; 2 Sapienza University of Rome, Italy, NESMOS Department
To present the case of a patient in treatment with quarterly paliperi- Neurosciences, Mental Health and Sense Organs Unit of Psychological
done palmitate injectable who presented a sinus bradycardia that Medicine, Sant’Andrea Hospital, School of Medicine and Psychology,
disappeared after his suspension. Rome, Italy
Methods.– Perform a literature search about the side effects of * Corresponding author.
paliperidone palmitate.
Results.– The most common cardiovascular effects of paliperi- Background and aims.– Effective treatment of negative symptoms is
done palmitate are tachycardia and arterial hypertension, although one of the most important unmet need in schizophrenia and affects
bradycardia can also produce the adverse effect, although it is a very functional outcome. The evidence on current psychopharmacolog-
rare side effect. In the case presented, the fact that the suspension ical treatments is yet unclear.
of the treatment was reversed and the lack of any other cause that To compare clinical and functional outcomes in patients with
the explanation supports was due to the drug. schizophrenia initiated with long-acting antipsychotic injections
Conclusions.– It is important to control the physiological variables (LAIs) versus oral antipsychotic during a follow-up period of 12
in patients with antipsychotic treatment, since it may be the case months.
that a message of adverse problems appears for the years after the Methods.– Statistical analyses were conducted from a 1-year study
start of treatment. of 41 stable schizophrenia patients (mean age = 36.4, SD = 11.1)
Disclosure of interest.– The authors have not supplied a conflict of to compare patients received LAIs treatment (n = 16), clozapine
interest statement. (n = 13) and other oral antipsychotic treatments (n = 12). Clinical
data was assessed through the Positive and Negative Syndrome
Scale (PANSS) and the Global Assessment of Functioning (GAF). For
E-PP1055 statistical analysis, we used the Wallwork’s five-factor model of the
Pregnancy delusion in men: case PANSS.
report Results.– Patients with LAIs significantly improved on GAF and
F. Cherif* , M. Maalej, A.S. Ellouze, S. Omri, R. Feki, L. Zouari, M. PANSS factor score for positive, negative, disorganised/concrete
Maalej, N. Charfi, J. Ben Thabet and excited symptoms from baseline to 12 months. Patients with
Hédi Chaker University Hospital, Psychiatry C, Sfax, Tunisia clozapine improved on GAF and all psychopathological factors.
* Corresponding author. Patients with other oral antipsychotics improved on GAF and on
all clinical dimensions with the exception of negative symptoms.
Background and aims.– A delusional pregnancy in males is regarded Conclusions.– All treatments were efficacy to improve global func-
as particularly exotic but poorly described in the literature. Our aim tioning and productive symptoms of schizophrenia. LAIs improved
was to describe a clinical case of pregnancy delusion in a man and negative symptoms as well as clozapine. However, clozapine,
its after effect. because of its risk for causing agranulocytosis or seizures, is not
Methods.– We report the case of Mr. R.K, 22 years old. recommended, whereas LAIs result in better adherence and may
Results.– He was single and unemployed. He was diagnosed as hav- be used from the early stage of the disease.
ing schizophrenia at 20. The patient was first admitted to psychiatry Disclosure of interest.– The authors have not supplied a conflict of
department at the age of 21. During the interview, he reported interest statement.
that his neighbor raped him. One year later, he was hospitalized
once again for suicidal thoughts. He was ashamed because of the
rape. He felt guilty. He believed that he did not deserve to live.
E-PP1057 delusions, avolition, apathy, and depression were associated with

Social cognition in schizophrenia diminished recognition of humor. Moreover, findings on the associ-
patients and their first-degree ations between cognitive skills and humor comprehension indicate
the need to account for the cognitive functioning when evaluating
relatives: clinical and functioning humor.
correlates Methods.– 40 schizophrenia-diagnosed subjects provided humor
V. Corigliano1* , A. Comparelli1 , J. Dehning2 , F. Forcina1 , P. comprehension and funniness ratings for 60 cartoons and 60 sto-
Bargagna1 , I. Mancinelli1 , A. De Carolis3 , D. Erbuto1 , M. Pompili1 ries with funny, neutral and absurd punchlines based on the Chan’s
1 Sapienza University of Rome, Italy, NESMOS Department
humor task. The severity of psychopathology was assessed with
Neurosciences, Mental Health and Sense Organs Unit of Psychiatry, PANSS. To examine general cognitive functioning MoCA was used.
Sant’Andrea Hospital, School of Medicine and Psychology, Rome, Results.– Significant correlations of humor comprehension and
Italy; 2 Sapienza University of Rome, Italy, School of Medicine and funniness ratings with psychopathological symptoms and other
Psychology, Rome, Italy; 3 Sapienza University of Rome, Italy, clinical characteristics were found. The associations between
NESMOS Department Neurosciences, Mental Health and Sense humor task ratings, chlorpromazine equivalents of neuroleptics
Organs Unit of Psychological Medicine, Sant’Andrea Hospital, School and sex did not reach statistical significance. MoCA score and age
of Medicine and Psychology, Rome, Italy showed several significant correlations with humor task ratings.
* Corresponding author. Disorganization syndrome was found to associate with deficits
in humor comprehension and experienced funniness in non-
Background and aims.– Research consistently demonstrates that
humorous stimuli after controlling for cognitive performance, age,
schizophrenia patients have theory of mind (ToM) impairments.
sex and medication.
Additionally, there is some evidence that family members of
Conclusions.– Humor perception seems to be associated with the
schizophrenia patients also demonstrate impairments in ToM, sug-
severity of symptomatology, which manifests in the understand-
gesting a genetic vulnerability for the disorder.
ing of humorous material and in the subjective appreciation of
This study aimed to compare social cognition between schizophre-
funniness of a material not intended to be humorous. Cognitive
nia patients, first-degree relatives and healthy controls and to
functioning is associated with deficits in humor perception.
examine the relationship between severity of illness and social
cognition impairment.
interest statement.
Methods.– Forty-three schizophrenia patients, 25 first-degree rela-
tives and 36 unaffected healthy control subjects were assessed to
examine social cognition ability. Clinical data was assessed through E-PP1059
the Positive and Negative Syndrome Scale (PANSS), The Awareness
of Social Inference Test (TASIT), the Mayer-Salovey-Caruso Emo-
Patient’s choice in clozapine dosage
tional Intelligence Test Managing Emotion-branch (MSCEIT) and titration; capillary blood verus
the Personal and Social Performance Scale (PSP). ANOVA analysis endovenous extraction
adjusted for possible confounder factors and subsequent planned M. De Dios Felis1* , S.T. Castillo Magana1 , E. Mur Mila2 , J. Moreno
contrasts with healthy controls was undertaken. Monmany3 , M.A. Cencerrado Muñoz1 , D. Navas Alcalà1 , A. Trabsa
Results.– Schizophrenia patients showed significant lower social Biskri1 , E. Monteagudo Gimeno4 , S. Pérez González4 , S. Oller
cognition scores in TASIT and MSCEIT tasks than their first-degree Canet1
1 Institut de Neuropsiquiatria i Addiccions, Centre de Salut Mental
relatives and controls. A trend significance in social cognition
tasks performance was found between schizophrenia relatives Martí i Julià, Santa Coloma de Gramanet, Spain; 2 Insitut de
and healthy controls, with lower social cognition scores in rela- Neuropsiquiatria i Addiccions, Centre de Salut Mental Martí i Julià,
tives rather than healthy controls. Social cognition impairment in Santa Coloma de Gramanet, Spain; 3 Institut de Neuropsiquiatria i
schizophrenia patients was also significantly associated with major Adiccions, Centre de Salut Mental Martí i Julià, Santa Coloma de
clinical severity and lower functional outcome. Gramanet, Spain; 4 Institut de Neuropsiquiatria i Addiccions, Hospital
Conclusions.– The presence of ToM impairments in relatives sug- del Mar, Barcelona, Spain
gests a potential genetic role of social cognition in schizophrenia, * Corresponding author.
fitting the pattern of a vulnerability indicator. Moreover, the
relationship between social cognition deficits and clinical and func- Background and aims.–
tioning impairments in schizophrenia patients suggests a possible Background.– Approximately 30% of Schizophrenia patients are
role of ToM as a rehabilitation target. considered resistant to antipsychotic treatment and clozapine is
Disclosure of interest.– The authors have not supplied a conflict of the only drug approved in patients with antipsychotic resistance.
interest statement. However, prescription rates are low and there is a theoretical delay
of initiation of 48 months partly due to the need of haematological
monitoring.
E-PP1058 Aim.– To describe if patients prefer to do haematological controls
though capillary blood test or with endovenous blood.
On the relation between humor
Methods.– Patients in treatment with clozapine were recruited in
perception and symptoms in ambulatory mental health devices during 2017 and followed up for
schizophrenia 6 months. The allocation was randomized and not blinded. Capillary
A. Daren1* , P. Adamczyk2 , P. Bładzi
˛ ński1 , A. Cechnicki1 blood was analysed with Hemocue WBCDIFF which quantifies total
1 Jagiellonian University Medical College, Department of Community leukocytes and a differential recount of with cells
Psychiatry, Krakow, Poland; 2 Jagiellonian University Institute of Results.– A total of 30 patients were recruited and 28 of them com-
Psychology, Psychophysiology Unit, Krakow, Poland pleted the follow up. In the sample 67.9% were male, mean age
* Corresponding author. was 43.07 years (SD+/− 9.68). Mean duration of treatment with
clozapine was 11.3 years (SD+/− 7.6), 46.4% were treated only with
Background and aims.– Sense of humor has been found to be dis-
clozapine, 53.6% needed oral treatment with other antipsychotic
turbed in people with schizophrenia yet current literature is limited
drugs (mostly aripiprazole), 60.7% needed treatment with benzo-
and ambiguous on its relationship to psychopathology. While some
diazepines, 42.9% needed antidepressant (mostly SSRI) and 28.6%
research found no significant relationships, in other either total
needed antiepileptic. 46.4% reported smoking, 3.6% alcohol use and
psychopathology score, positive syndrome, cognitive symptoms,
3.6% cannabis use. After randomisation 50% of the patients were
included in the capillary blood group, only patients from this group Background and aims.– Recent studies in our country show an
were asked about extraction method preference and 93.3% of them infertility rate between 15–17% of the population, with the
choose capillary blood extraction. rate experiencing an increasing tendency. Over the last decades,
Conclusions.– Clozapine titration through capillary blood extraction assisted reproduction techniques (ART procedures) have revolu-
might increase its prescription as it would make monitoring easier tionized the treatment of infertility. Infertility, mental disorders
both for patients and the health system. and infertility treatments are related to one another in a very com-
Disclosure of interest.– The authors have not supplied a conflict of plex way. Estrogens have been associated as a possible protective
interest statement. factor for psychosis in women. The prevalence of psychological
disorders among women treated for infertility is unknown. An inef-
fective treatment for infertility could be an independent risk factor
E-PP1060 for the development of psychiatric disorders, particularly psychotic
Prominent negative symptoms in disorders.
psychotic disorders. Classification Objectives.– To report a clinical case study of psychotic disorder
in a patient who has undergone ovulation induction therapy with
challenges throughout a case
gonadotropins.
H. De La Red Gallego* , A. Álvarez Astorga, A. Alonso Sánchez, C.M.
Methods.– Descriptive study of a clinical case and literature review
Capella Meseguer, M. Gómez García, L. Rodríguez Andrés, C. Noval
of the subject.
Canga, S. Gómez Sánchez, R. Hernández Antón, F. De Uribe Ladrón
Results.– We describe the case of a 40-year-old woman with uter-
de Cegama
ine pathology (endometriosis and myomas) that causes sterility.
She performs four attempts of conception at in vitro fertiliza-
Spain
tion, without success. Days after receiving the last cycle (human
gonadotropin and follitropin alfa), the woman presents intense
Background and aims.– We intend to make a historical approach anxiety, insomnia, sensation of strangeness, auditory hallucina-
to simple schizophrenia, as well as to discuss its controversies and tions in the form of imperative voices and self-referential delusional
successors after its withdrawal from DSM. A description of a clinical ideation, with alteration of secondary behavior. Treatment: arip-
case is presented. iprazole 15 mg/day with remission of the psychotic clinic after
Methods.– A 38-year-old woman with a history of subtle and self- several weeks.
limited psychotic symptoms three years ago, who describes social Conclusions.– Despite the increase in the prevalence of ART, there is
isolation, abulia, inability to work, pseudoneurological complaints. no consensus regarding the psychological and psychiatric manage-
Repetitive non-egodystonic, poverty of thought and tangential, ment of mental health complications associated with the diagnosis
stereotyped language were highlighted. and treatment of infertility.
Results.– Neurological examination and brain MRI were normal. Disclosure of interest.– The authors have not supplied a conflict of
Antipsychotic and anxiolytic treatment was performed. Then, interest statement.
the anguish and the restriction of interests improved. Neuropsy-
chological evaluation suggests memory and executive functions
impairment.
Conclusions.– Psychiatric nosography implies the existence of clas-
E-Poster Presentation: Schizophrenia and other
sificatory controversies. One of the main difficulties is the inclusion psychotic disorders - Part III
of a psychotic syndrome without striking positive symptoms.
Negative symptoms can be prominent. It has been conceived as
latent schizophrenia (Bleuler), schizophrenic pseudoneurosis (Ey), E-PP1062
pseudoneurotic schizophrenia (Hoch and Polatin), schizoneurosis Postpartum psychoses versus
(Ey) or ordinary psychosis (Miller). In simple schizophrenia there is
functional psychoses: a comparison of
a deteriorating course with progressive impoverishment in affec-
tive, cognitive and social functioning. It is a controversial diagnosis behavioral phenotypes and genetic
that keeps creating debate. Despite its removal from DSM III, it is susceptibility
still present either as “simple deteriorating disorder” in DSM-IV-TR L. Dehelean1* , S. Milos2 , R. Balint2 , A.M. Romosan1 , I. Papava1 , R.S.
or “attenuated psychosis syndrome” in DSM 5. However, it is still Romosan1
1 Victor Babes University of Medicine and Pharmacy, Neurosciences,
accepted in ICD-10.
Disclosure of interest.– The authors have not supplied a conflict of Timisoara, Romania; 2 Timisoara Psychiatric Clinic, Psychiatry II,
interest statement. Timisoara, Romania
E-PP1061 Background and aims.– ICD-10 considers postpartum psychosis a

separate psychosis in itself (F53), while in DSM-5 it is a form of
Psychotic reaction during the either mood disorder with psychotic symptoms, or of brief psy-
treatment of infertility with chotic disorder triggered by birth.
gonadotropins The study aims to compare the behavioral phenotypes and genetic
M. De Lorenzo Calzón1* , M. Gómez García1 , N. De Uribe Viloria1 , H. vulnerability of patients with postpartum psychosis versus patients
De la Red Gallego1 , A. Álvarez Astorga1 , A. Alonso Sánchez1 , C. with functional psychoses not related to puerperium.
Capella Meseguer1 , E. Rodríguez Vázquez1 , I.D.L.M. Santos Methods.– The study included two samples of inpatients diagnosed
Carrasco1 , J.I. Gonçalves Cerejeira1 , J. Montoro López2 , A. according to ICD-10 criteria with psychosis, one consisting of sub-
Rodríguez Campos1 jects with postpartum psychosis at the index episode (PP) and the
1 Hospital Clínico Universitario de Valladolid, Psiquiatría, Valladolid,
other of female subjects with schizophrenia, schizoaffective and
Spain; 2 Red de Salud Mental de Navarra, Psiquiatría, Valladolid, bipolar disorder (non-PP). We analyzed: socio-demographics, age
Spain at disorder onset, the mean duration and the number of psychotic
* Corresponding author. episodes, psychiatric family history, suicidal attempts, substance
abuse and psychiatric symptoms at index episode.
Results.– The study was conducted on 62 patients: 31 in the propensity to negative symptoms, there is a higher prevalence of a
PP group, and 31 in the non-PP group. We found no significant continuous course of schizophrenia and a social functioning lower.
differences between the samples concerning: suicidal attempts, Disclosure of interest.– The authors have not supplied a conflict of
history of family violence, substance abuse and psychiatric fam- interest statement.
ily history. Subjects with psychiatric family history had a higher
number (p = 0.034) and a longer duration (p = 0.03) of psychotic
episodes. Postpartum psychosis evolved towards the following E-PP1064
diagnoses: bipolar disorder (6.5% patients), recurrent depressive Proteomic research in psychiatry:
disorder (12.9%), schizoaffective disorder (16.1%), and schizophre- schizophrenia
nia (32.3%). 32.3% of PP patients remained with a single postpartum E. Dmitrieva1* , L. Smirnova1 , A. Letova2 , V. Dubrovskaja1 , N.
psychotic episode. Krotenko1 , E. Kornetova1 , A. Semke1 , S. Ivanova1
Conclusions.– The study did not reveal significant differences 1 Tomsk National Research Medical Center of the Russian Academy of
between postpartum psychosis and other functional psychoses Sciences, Mental Health Research Institute, Tomsk, Russia; 2 Siberian
regarding behavioral phenotypes and genetic vulnerability. How- State Medical University, Medicobiologic faculty, Tomsk, Russia
ever, a family history of psychiatric disorders may increase the risk * Corresponding author.
of psychotic recurrences.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– Multifactorial aspects of schizophrenia have
interest statement. always impeded study of biochemical characteristics and delayed
creation of preclinical models the disease. Proteomic studies
may indicate pathological changes in brain cells of schizophrenia
E-PP1063 patients, which contributes to understanding its molecular mech-
Determinants of clinical evolution anisms.
and social functioning in Methods.– We used serum of 20 healthy and 30 patients with
schizophrenia. Samples preparation included: serum purifica-
schizophrenia in middle-income
tion from major proteins via affinity chromatography, 1D-PAGE
countries: evidence from Mexico proteins separation, in-gel tryptic hydrolysis, LC-MS/MS mass-
L. Díaz-Castro Psychiatrist1* , H. Cabello-Rangel2 spectrometry (Orbitrap Q-exacutive HF mass spectrometer, Agilent
1 Psychiatric Care Services- Health Secretary, Department of Technologies). Identification of proteins was carried out using Mas-
Investigation, Mexico City, Mexico; 2 Psychiatric Hospital “Fray cot software Ver. 2.1 («Matrix Science», USA).
Bernardino Álvarez, Division of diagnostic aids, Mexico City, Mexico Results.– We identified proteins that were mostly involved in bio-
* Corresponding author. logical processes, such as regulation of nucleic acid metabolism,
protein metabolism, cell communication, immune response. For
Background and aims.– Sex and age at onset are associated with
example, cadherin 5 and protocadherin fat 2, participate in cellular
symptoms at the time of presentation of the Schizophrenia, but the
communication and signaling, especially in actin-dependent sig-
effect of these factors on the long term course of SCH has not been
naling, which recently received great attention in the development
determined.
of diseases with an inflammatory component. In addition, identi-
Objective.– We determine what factors in people with schizophre-
fied proteins participate in transcription regulation, for instance,
nia are predicted with a continuous evolution of the disease, and a
zinc finger X-linked protein ZXDA, KRAB domain-containing pro-
worse social functioning.
tein ZNF747. These proteins playing an important role in brain
Methods.– This study was carried out from 2009–2010. Patients
development, as well as in the development of mental and cognitive
were interviewed, and a diagnosis was assigned based on DSM-IV
disorders.
criteria. In order to examine the relationship between the factors
Conclusions.– Identified proteins could be included in sensitive and
that determine the schizophrenia and its evolution, we developed
specific biomarker panel for schizophrenia diagnostic, and for eval-
a path analysis using a General Modeling of Structural Equation in
uating subsequent response to treatment.
STATA 14.
Acknowledgments.– Support by Grant of RSF № 18-15-00053. Mass
Results.– The male sex (Coef. 1.022) and the schizoid premorbid
spectrometric analysis was carried out using the equipment of
personality (Coef. 3.393), have a positive and significant effect with
“Human Proteome” Core Facility of the Institute of Biomedical
schizophrenia. A high value of PANSS Negative suggests that the
Chemistry (IBMC) Moscow which is supported by Ministry of Edu-
patient tends not to have a relationship (Coef. −0.578), does not
cation and Science of the Russian Federation (unique project ID
have a paid job and would not be an enrollment in an educational
RFMEFI62117X0017).
program (Coef. −0.578) (Fig. 1).
interest statement.
E-PP1065
A smartphone guided experience
sampling study: impact of childhood
trauma and expressed emotion level
on stress sensitivity in psychotic
patients
G. Dokuz1* , M.K. Kuşçu2
Figure 1. Model the relationship among factors determining the 1 Elbistan State Hospital, Psychiatry, Kahramanmaraş, Turkey; 2
presence of SCH and its evolution and social functioning.
Marmara University School of Medicine, Psychiatry, İstanbul, Turkey
Conclusions.– There are several factors that confer vulnerability to * Corresponding author.
schizophrenia, mainly the susceptibility on the male sex; as the
father with schizophrenia, a schizoid premorbidity and a higher Background and aims.– Stressors such as traumatic life events and
rating of negative symptoms, and when men show a greater high expressed emotion play a role in the onset and relapses of
psychotic disorders. Sensitivity to stress is defined as an increased
emotional and behavioral response to daily life events and consid- Disclosure of interest.– The authors have not supplied a conflict of
ered one of the main features of psychosis. interest statement.
The aims of this study were (a) to investigate the link between
daily life events, emotional and psychotic experiences in real life
conditions (b) to determine the impact of childhood trauma and E-PP1067
caregivers’ expressed emotion levels on these three variables (c) Assessment of cardiorespiratory
to examine the differences in emotions and psychotic experiences capacity and physical fitness in
among the types of daily life events.
patients with schizophrenia
Methods.– Daily life experiences, emotional reactions and psy-
K. Drews1* , A. Jasińska-Mikołajczyk2 , K. Katarzyna
chotic symptoms of the forty-one outpatients with psychosis were
Domaszewska3 , F. Rybakowski2
assessed with the experience sampling method (a momentary self- 1 Poznań University of Medical Sciences, Department of Adult
assessment technique collecting information with signals ten times
Psychiatry, Poznań, Poland; 2 Poznan University of Medical Sciences,
daily on six days by a smartphone). SCID-I, PANSS, Childhood
Department of Adult Psychiatry, Poznań, Poland; 3 Poznań University
Trauma Questionnaire (CTQ), Level of Expressed Emotion Scale and
School of Physical Education, Department of Physiology, Poznań,
Expressed Emotion Scale were also used.
Poland
Results.– High CTQ scores were positively correlated with daily life
stress, negative emotions and psychotic symptoms. Patients with
high expressed emotion experienced more activity related stress, Background and aims.– Mental disorders are often associated
negative emotions and psychotic symptoms during the time they with respiratory, metabolic or cardiovascular diseases. The life
spend with their caregivers. Among the types of daily life events, expectancy of people suffering from schizophrenia is, on average,
the most social experiences were related to psychotic symptoms 15 years shorter in the general population. The only risk factor for
and negative emotions and this relationship was determined by the development of diseases within these systems is sedentary and
high CTQ scores. unhealthy lifestyle in this group of patients.
Conclusions.– Our study confirmed that sensitivity to stress and The study aimed to compare physical fitness (cardiorespiratory fit-
symptoms of psychotic patients in real life condition are affected ness, strength, and flexibility, agility and balance) of hospitalized
by childhood trauma and caregivers’ expressed emotions. patient with schizophrenia (S, n = 16) and control group (C, n = 35).
Disclosure of interest.– The authors have not supplied a conflict of Methods.– The study group consisted of women and men (S, n = 16),
interest statement. diagnosed with schizophrenia (70–100, PANSS scale). Control
group (C, n = 39). Maximal oxygen uptake (VO2 max) was estimated
using the Astrand-Rhyming gender-sensitive nomogram. The phys-
E-PP1066 ical efficiency was assessed using a 6-task Fullerton test. One-way
Identifying the lack of services for ANOVA with post-hoc HSD Tukey test was used to assess the dif-
psychotic patients after the early ferences between groups.
psychosis intervention Results.– The conducted studies showed significant differences
R. Dolp1* , J. Pikard1 , M. McConnell2 , M. Habib1 between the patients (S, n = 16) and the control group (C, n = 35) in
1 Queen’s University, Psychiatry, Kingston, Canada; 2 Queen’s terms of physical performance (VO2 max), as well as the majority
University, Social Work, Kingston, Canada of parameters related to physical fitness.
* Corresponding author. Conclusions.– Patients with schizophrenia present poor level of
cardiorespiratory fitness. Therefore physical training should be a
Background and aims.– Early Psychosis Intervention (EPI) pro- permanent support of standard treatment.
grams are considered the gold-standard for patients experiencing Disclosure of interest.– The authors have not supplied a conflict of
psychosis. Those programs themselves are underused and lack suf- interest statement.
ficient wellness/recovery-oriented elements. After the EPI, there is
much to be desired with regards to follow up and services lead-
ing to patients either remaining longer than 3 years in the EPI or E-PP1068
not receiving the care they need. This systematic literature review Self-criticism, external shame, and
was completed to quantify availability and outcomes of offered psychopathological symptoms: is
programs for psychotic patients after EPI treatment.
self-criticism a mediator between
Methods.– We used Medline, PsycInfo, CINAHL databases and
the search terms “psychosis“, “psychotic“, “self-management“, external shame and
“program development“, “program evaluation“, “psychiatric reha- psychopathological symptoms in
bilitation“, and “mental health recovery“. English language papers institutionalized women diagnosed
only were retrieved. After sparse results, we conducted an informal with schizophrenia?
google search for Canada. C. Madeira-Sério, I. Garcia, L. Lemos, C. Duarte* , H. Espírito-Santo
Results.– Fifty-five papers were retrieved in the formal search, of Instituto Superior Miguel Torga, Psychology Department, Coimbra,
which 9 addressed specific programs after the EPI. The 9 included Portugal
articles originated in USA, UK, Singapore and Netherlands. Offered * Corresponding author.
programs had a great heterogeneity in structure and time-frame
and focused on different outcomes to evaluate treatment success Background and aims.– Early emotional experiences associated with
making it impossible to compare them. All programs reported shame appears to significantly influence the psychobiological func-
significant efficacy. None had a long-term follow up proceeding tioning, having been related to vulnerability to psychopathology.
treatment. The informal search only found services in 5 out of the Other studies also confirm that self-criticism plays a role in the
10 Canadian provinces. No study data in regard to their outcome development of psychological problems. This study intends to eval-
was available. uate the role of self-criticism (the Inadequate Self) as a mediator in
Conclusions.– There is a great lack of availability and research of the relationship between external shame and psychopathological
programs supporting psychotic patients after Early Psychosis Inter- symptoms among patients with schizophrenia.
vention programs. More programs need to be implemented to cover Methods.– The sample consisted of 41 institutionalized women
the high needs in all provinces of this patient population. with a diagnosis of schizophrenia, were aged between 31 and 77
years old (M = 54.10; SD = 11.12).
Results.– The mediation analysis showed that the Inadequate Self 1 Hedi Chaker University Hospital, Psychiatry “C” Department, Sfax,
significantly predicts the psychopathological symptoms [ˇ = 0.04, Tunisia; 2 Habib Bourguiba University Hospital, Biochemistry
t(38) = 2.97, p = .0051], when faced with external shame. It was also Laboratory, Sfax, Tunisia; 3 Sfax Medicine School, UR : 12ES17 «
found an indirect effect of external shame on psychopathological Molecular basis of human pathology », Sfax, Tunisia
symptoms (ˇ = 0.012, p = .001) through the Inadequate Self. * Corresponding author.
Conclusions.– A form of self-criticism, the Inadequate Self, is associ-
ated positively with external shame; and, also has a mediator role in Background and aims.– Schizophrenia is a disabling mental dis-
the relationship between external shame and psychopathological order. Its diagnosis is often delayed because of the absence of
symptoms in patients with schizophrenia. specific biological markers. The role of cortisol in the pathology of
Disclosure of interest.– The authors have not supplied a conflict of schizophrenia remains controversial. We aimed to study the role
interest statement. of basal cortisol assay in the acute phase of schizophrenia.
Methods.– This was a cross-sectional case-control study con-
ducted between June 2016 and July 2018 on antipsychotic-free
E-PP1069 schizophrenia patients compared to healthy controls. Patients were
Gluten sensitivity, schizophrenia and hospitalized at the psychiatric C department in Hedi Chaker Uni-
versity Hospital (UH) in Sfax. The diagnosis of schizophrenia was
factors related with: what is known,
established according to DSM-5 criteria. The symptoms’ severity
what is new? was evaluated according to the positive and negative syndrome
M. Dzikowski1* , J. Rog1 , M. Kozioł2 , I. Dzikowska3 , D. Juchnowicz4 , scale. Cognitive functions were evaluated according to the Mon-
H. Karakuła-Juchnowicz1 treal Cognitive Assessment scale. The analysis of cortisol levels was
1 Medical University of Lublin, I Department of Psychiatry-
performed in the laboratory of Biochemistry in Habib Bourguiba
Psychotherapy and Early Intervention, Lublin, Poland; 2 Medical UH in Sfax.
University of Lublin, Department of Medical Microbiology, Lublin, Results.– This study included 45 patients and 100 male controls.
Poland; 3 Medical University of Lublin, Department of Dermatology, The blood cortisol level was significantly higher in schizophre-
Venereology and Pediatric Dermatology, Lublin, Poland; 4 Medical nia patients compared to controls. (140,12 ± 49,79 ng/ml vs
University of Lublin, Department of Psychiatric Nursing, Lublin, 122,70 ± 40,77 ng/ml; p = 0,029). There was no significant differ-
Poland ence between the two groups regarding salivary cortisol levels.
* Corresponding author. There was a significant and negative correlation between salivary
cortisol levels and the severity of negative symptoms. Positive and
Background and aims.– Meta-analyses point out that patients suffer-
significant correlations were found between salivary cortisol levels
ing from schizophrenia have elevated serum biomarkers of gluten
and cognitive functions.
sensitivity, and their immune response is different from that of
Conclusions.– This study allowed better understanding the role of
celiac disease patients’. The factors and potential confounders link-
basal cortisol assay in the acute phase of schizophrenia. Further
ing an abnormal immune response and non-affective psychosis
research is needed to improve our knowledge about its role in the
remain unclear.
different phases of this disorder.
The aim of the study was to (1) compare an abnormal immune
response to gluten between patients suffering from schizophre-
interest statement.
nia and healthy individuals; (2) assess the influence of the disease
stage and gender as the factors affecting an immune response in
schizophrenia patients.
E-PP1071
Methods.– We examined 52 (55.8% male) first-episode of psychosis
patients (FS group), 50 (50.2% male) chronic patients (CS group) Treatment adherence and persistence
who fulfilled DSM-5 criteria for schizophrenia, and 60 (41.7% male) with oral second-generation
healthy individuals as a control group (HC). The levels of gluten antipsychotics in patients with
sensitivity biomarkers (anti-gliadin antibodies, AGA IgG/IgA) were schizophrenia in Spain and Denmark
measured. C. Emborg1* , K.T. Jørgensen2 , M. Rosenlund3 , K. Starup Simonsen4 ,
Results.– We found differences in positive AGA IgA levels: CS>FS>HC P. McMahon3 , A.G. Nylander5 , J. Wang-Silvanto6 , J. Bobes7
(26% vs 11.5% vs 5% respectively) and AGA IgG levels: FS>CS>HC 1 Aarhus University, Department of Clinical Medicine - Psychosis
(30.8% vs 20% vs 10% respectively) between the groups (p < 0.05). Research Unit, Aarhus, Denmark; 2 H. Lundbeck A/S, RWE Medical
In CS group, positive AGA levels were more often found in men than Affairs, Valby, Denmark; 3 IQVIA, IQVIA Sweden, Solna, Sweden; 4 H.
in women (89% vs 11% respectively) (p < 0.05). Lundbeck A/S, HEE Statistics, Valby, Denmark; 5 H. Lundbeck A/S,
Conclusions.– An abnormal immune response to gluten was more Medical Affairs, Valby, Denmark; 6 Otsuka Pharmaceutical Europe
frequently observed in schizophrenia patients compared to healthy Ltd., Evidence Generation, Wexham, United Kingdom; 7 University of
individuals. In the patient group, the response depended on the Oviedo, Department of Psychiatry, Oviedo, Spain
disease phase and gender. The mechanisms underlying the dif- * Corresponding author.
ferences are still unclear. An investigation of IgG/IgA antibodies
against gluten peptides in this group of patients could be helpful in Background and aims.– Schizophrenia is a heterogeneous and bur-
providing personalized medicine involving dietary approaches. densome disease that can lead to loss of functioning and patient
Disclosure of interest.– The authors have not supplied a conflict of autonomy. Today, most patients are treated with oral second-
interest statement. generation antipsychotics (SGAs); however, lack of treatment
adherence and persistence may represent important treatment
challenges.
E-PP1070 This study aimed to investigate treatment adherence and persis-
Contribution of basal cortisol assay in tence of oral SGAs in patients with schizophrenia overall and in
the exploration of the acute phase of younger patients (≤35 years).
Methods.– Schizophrenia diagnosis and prescription data from 124
schizophrenia
psychiatry clinics in Spain and national patient and prescription
A.S. Ellouze1* , M. Naifar2 , M. Maalej1 , K. Jmal2 , W. Guidara3 , S.
registries in Denmark were studied between 2013-2016. Treatment
Omri1 , M. Maalej1 , F. Ayadi2 , N. Charfi1 , J. Ben Thabet1
adherence was estimated as the proportion of days covered (PDC)
by drug supply per treatment episode, and treatment persistence
as the proportion of patients discontinuing treatment within 6 and E-PP1073

12 months. Vortioxetine as add-on strategy for
Results.– Among patients prescribed antipsychotics, the major-
treating negative symptoms in
ity were prescribed oral SGAs [Spain 78% (1,965/2,507 patients),
Denmark 76% (12,983/17,193)].
schizophrenia
Patients prescribed oral SGAs showed good treatment adherence D. Esteves-Sousa1* , J. Gago2 , S. Gomes-Pereira2 , D. Neto2 , J.
(PDC: Spain 84%, Denmark 80%). However, many patients discon- Facucho-Oliveira1 , M. Albuquerque1 , L. Mendonça1
1 Hospital de Cascais, Departamento de Psiquiatria e Saúde Mental,
tinued oral SGA treatment within 6 months (Spain 20%, Denmark
25%) and 12 months (Spain 33%, Denmark 40%). Younger patients Lisboa, Portugal; 2 Centro Hospital Lisboa Ocidental, Departamento
had similar adherence (Spain 80%, Denmark 77%) but more treat- de Psiquiatria e Saúde Mental, Lisboa, Portugal
ment discontinuation after 6 (Spain 25%, Denmark 37%) and 12 * Corresponding author.
months (Spain 40%, Denmark 56%) than patients overall. Background and aims.– The overwhelming majority of patients
Conclusions.– Results from Spain and Denmark showed that despite with Schizophrenia suffer to some extent from negative symptoms
good adherence, numerous patients with schizophrenia (especially (NSS). Indeed, multiple clinical and pharmacological interventions
younger patients ≤35 years) discontinued their oral SGAs within have been the subject of investigation, but to this point, the efficacy
one year after treatment initiation. These results highlight the of actual treatments is questionable. Selective serotonin reuptake
unmet need for alternative oral antipsychotics to improve treat- inhibitors are one of the promising approaches, having the addi-
ment persistence and meet the needs of individual patients with tional benefits of being relatively safe and innocuous. Vortioxetine
schizophrenia. has a unique receptor-binding profile and pharmacodynamic prop-
Disclosure of interest.– The authors have not supplied a conflict of erties that provided a non-clinical rationale to investigate it’s use
interest statement. on NSS.
This case-report intend to raise the discussion on the relevance and
safety of adjunctive use of vortioxetine for the treatment of NSS.
E-PP1072
Methods.– The case-report was described with data retrieved from
A calling to become a priest: a case of the clinical file.
psychotic symptoms in a patient with Results.– Here, we report a case, selected from a case series, of a 44-
temporal lobe epilepsy year-old man diagnosed with Paranoid Schizophrenia, stabilized
P. Espada Dos Santos* , J. Facucho, M. Costa, M. Albuquerque, D. with antipsychotic medication, but with persistent NSS. NSS and
Sousa, P. Cintra, L. Mendonça, A. Moutinho, J. Tropa cognitive symptoms (CSS) were assessed using Clinical Assessment
Hospital de Cascais, Saúde Mental - Unidade Funcional de Psiquiatria, Interview For Negative Symptoms (CAINS) and Addenbrooke’s Cog-
Alcabideche, Portugal nitive Examination (ACE), respectively, and Vortioxetine 10 mg/day
* Corresponding author. was initiated. Since first month, patient appeared more sociable,
less apathic, with more fluent speech and better facial/vocal expres-
Background and aims.– The nature of the relationship between psy- sion. Remarkably, NSS and CSS had a progressive clinical change,
chosis and epilepsy has been of great interest to psychiatrists given with a 33% decrease in NSS and 13% raise in cognitive performance.
that epilepsy has long been shown to be a risk factor for psychosis. No major safety issues appeared.
Several studies report a higher prevalence of psychosis in patients Conclusions.– There is some data supporting partial benefits in the
with epilepsy compared with the general population. In particular, use of antidepressants in NSS and no relevant data specifically for
postictal psychosis has been described as the most common form vortioxetine. The significant change in NSS and CSS of this patient
of psychosis in patients with temporal lobe epilepsy or refractory shows a promising effect. Further clinical studies will help clarify
epilepsy. We describe a case of an epileptic patient who travelled this potential therapeutic role.
from Portugal to London to become a priest during a postictal psy- Disclosure of interest.– The authors have not supplied a conflict of
chotic episode. interest statement.
Methods.– A 48-year-old man with a diagnosis of epilepsy at age
18, with a predominantly refractory right temporal lobe epilepsy
was observed at the Psychiatry Department with and found to be E-PP1074
suffering from anxiety, insomnia and agitation. Past The patient’s Comparison of personal and social
psychiatric history started at age 42 when he had his first psychotic
performance scale (PSP) between
episode with auditory allucinations, persecutory and religious-
mystical delusions. Since then he had several self-auto limited healthy young people and younglings
postictal psychotic episodes, of which the patient is amnesic which affected by schizophrenia: a case
the patient does not remember, and which have had with a negative control study
social and professional negative impact. A. Fernández Alonso* , J. Herranz Herrer, M.T. Gonzalez Salvador
Results.– The patient was prescribed with lamotrigine, lacozamide, Hospital Puerta de Hierro Majadahonda, Department of Psychiatry,
valproic acid, clonazepam and risperidone, with littlepoor effect Majadahonda, Spain
on control of the seizures but with total remission of psychotic * Corresponding author.
symptoms.
Conclusions.– An adequate recognition and treatment of psychosis Background and aims.– The Personal and Social Performance (PSP)
in epilepsy is essential for patient management and quality of life. scale is a clinical assessment instrument which proves useful when
Disclosure of interest.– The authors have not supplied a conflict of assessing the previous functioning of people affected by serious
interest statement. mental disorders. This scale allows to make a general idea of the
functioning of the patient in five aspects of daily life and it also
detects problems in those aspects that may have preceded the dis-
ease. It estimates a duration of the disease onset, as well as its
repercussion. In this work we pretend to compare the PSP scores of
a sample of patients affected with schizophrenia with another sam-
ple made up of healthy volunteers with the intention to observe if
there are any differences.
Methods.– PSP scale was used in 10 healthy volunteers chosen in Marseille, France; 2 Aix-Marseille Univ, School of Medicine, La Timone
the educational setting and 20 patients diagnosed with stable phase Medical Campus, EA 3279: CEReSS - Health Service Research and
schizophrenia taken from a Mental Health Center. Both groups had Quality of Life Center, Marseille, France; 3 UMR S 1136-
a similar distribution of sexes and ages. INSERM-Institut Pierre Louis d’Epidémiologie et de Santé Publique-
Results.– Differences were found between both groups that were l’université Pierre et Marie Curie- Sorbonne Universités-France.,
collected in the table shown in the study, with better scores in the Fondation FondaMental, Créteil, France; 4 CHU Clermont Ferrand,
control group. adult academic psychiatry, Clermont-Ferrand, France
Conclusions.– Given that the study collected a small sample of both * Corresponding author.
groups, it would be necessary to expand the sample to reach con-
clusive results. We are also aware that there may be a volunteer Background and aims.– Aims. To determine the prevalence and asso-
bias in the control group that can produce favorable results in said ciated factors of Major Depressive Disorder (MDD), to compare the
group. The results, however, show differences that are likely to depressive symptoms levels of treated vs. non-treated SZ subjects,
be observed in other clinical scales, so it would be interesting to and to determine the prevalence and associated factors of non-
extend this study to a larger sample and include a wider clinical remission under treatment as well as potential biological correlates
assessment. (metabolic syndrome (MetS) and peripheral inflammation).
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Participants were consecutively included in the network
interest statement. of the FondaMental Expert Centers for Schizophrenia and received
a thorough clinical assessment. MDD was defined by a Calgary
score ≥6. Non-remitted MDD was defined by current antidepres-
E-PP1075 sant treatment (unchanged for more than 8 weeks) and current
Seasonal birth pattern regarding Calgary score ≥6.
Results.– 613 subjects have been included, and 175 (28.5%) were
patients with schizophrenia
identified with current MDD. In multivariate analyses, MDD has
S. Vedor1* , I. Ferraz1 , C. Silveira1 , I. Brandão1 , A. Silva1 , M.
been significantly associated with respectively paranoid delu-
Estevez1 , M.A. Vieira-Coelho1,2
1 Centro Hospitalar de São João, Psiquiatria e Saúde Mental, Porto, sion (OR = 1.8, p = 0.01), avolition (OR = 1.8, p = 0.02), blunted affect
(OR = 1.7, p = 0.04), and benzodiazepine consumption (OR = 1.8,
Portugal; 2 Faculty of Medicine, Biomedicine, Pharmacology and
p = 0.02). Antidepressants were associated with lower depressive
Therapeutics Unit, Porto, Portugal
symptoms score (5.4 vs. 9.5, p < 0.0001), however 44.1% of MDD
patients remained in non-remitted MDD despite of antidepres-
Background and aims.– The relationship between season of birth sant treatment. Compared to remitted patients, non-remitters were
and human disease susceptibility is well known. For schizophre- found to have more paranoid delusion (OR = 2.3, p = 0.009) and
nia, most of the studies reveal a decrease in late summer births more current alcohol use disorder (OR = 4.8, p = 0.04). No antide-
and an increase number of winter-spring births. There are various pressant class and no specific antipsychotic have been associated
factors that can explain this association, ranging from endocrine with higher or lower response to antidepressant. MDD was associ-
to immune factors. However, some studies do not confirm this ated with MetS (31.4% vs. 20.2%, p = 0.006) but not with increased
observation. CRP.
The present study aimed to analyse the seasonal birth month pat- Conclusions.– Antidepressant administration is associated with
tern in patients with schizophrenia. lower depressive symptom level in SZ subjects with MDD. Paranoid
Methods.– Retrospective database reviews were conducted on inpa- delusions and alcohol use disorder should be specifically explored
tients, hospitalized between January 2003 and December 2012 in and treated in case of non-remission under antidepressant treat-
Hospital de São João, Porto. Statistical population data was collected ment in SZ subjects with MDD.
in Eurostat. A total 370 patients were analyzed (102 women and 268 Disclosure of interest.– The authors have not supplied a conflict of
men), born between1929 to 1997. interest statement.
Results.– A seasonal distribution of births was detected with a peak
being reached in the month of May (11.6%). This profile, when com-
pared to general population in Portugal, displays the absence of a E-PP1077
second peak of births during the month of September. These differ- Machine learning for predicting
ences are highly more prevailing in the male gender, with a profile psychotic relapse at 2 years in
of 11.6% in May, 11.9% in June and 7.5% in September. schizophrenia in the national FACE-SZ
Conclusions.– In Porto, the pattern of birth seasonality of patients
cohort
with schizophrenia shows an increase of births during late win-
G. Fond1* , G. Ophelia2 , L. boyer1 , P.M. Llorca3
ter and early spring. In this view, we could hypothesize that these 1 Aix-Marseille Univ, School of Medicine, La Timone Medical Campus,
patients had higher risk of prenatal viral infections, more common
EA 3279: CEReSS, Health Service Research and Quality of Life Center,
in winter. Since the maternal inflammatory response has been asso-
Marseille, France; 2 Fondation Fondamental, Scientific Cooperation
ciated with fetal brain injury, this could explain the higher risk for
Foundation- F-94010, Epidemiology, Créteil, France; 3 CHU
developing schizophrenia.
Clermont-Ferrand, Psychiatrie, Clermont-Ferrand, France
interest statement.
Background and aims.– To determine the predictors of psychotic
relapse in a non-selected national sample of stabilized community-
E-PP1076 dwelling SZ subjects with a machine learning approach.
Insufficient remission of depression in Methods.– Participants were consecutively included in the network
subjects with schizophrenia and of the FondaMental Expert Centers for Schizophrenia. Relapse was
comorbid major depressive disorder. defined by at least one acute psychotic episode of at least 7 days,
reported by the patient, her/his relatives or by the treating psychi-
Results from the FACE-SZ cohort
atrist, within the 2-year follow-up. A classification and regression
G. Fond1* , L. Boyer2 , O. godin3 , P.M. llorca4
1 tree (CART) was used to construct a predictive decision tree of
Aix-Marseille Univ, School of Medicine, La Timone Medical Campus,
relapse.
EA 3279: CEReSS - Health Service Research and Quality of Life Center,
Results.– 549 patients were evaluated at baseline and 315 (57.4%) E-Poster Presentation: Schizophrenia and other
were followed-up at 2 years. On the 315 patients who received psychotic disorders - Part IV
a visit at 2 years, 125 (39.7%) patients had experienced psychotic
relapse at least once within the follow-up. High anger, high physical
aggressiveness, high lifetime number of hospitalization in psychi-
atry, low education level, and high positive symptomatology at E-PP1079
baseline were found to be the best predictors of relapse at 2 years, Practical and visual-constructive
with a percentage of correct prediction of 63.8%, sensibility 71.0% skills in schizophrenic patients
and specificity 44.8%. D. Galletta* , V.F. Papa, S. De Simone
Conclusions.– Machine learning can help constructing predictive U.O. Federico II, Neuroscience and Reproductive and
score. In the present sample, aggressiveness appears to be a good Odontostomatological Sciences, Naples, Italy
early warning sign of psychotic relapse and should be systemat- * Corresponding author.
ically assessed in SZ subjects. The other above-mentioned clinical
variables may help clinicians to improve the prediction of psychotic Background and aims.– Cognitive impairment and poor medical
relapse at 2 years. compliance are well recognized in subjects with schizophrenia. The
Disclosure of interest.– The authors have not supplied a conflict of aim of the present study is to examine the schizophrenic patients,
interest statement. emphasizing the cognitive profile, to identify the skills primarily
compromised. protocol aimed at measuring some cognitive func-
tions that highlight serious deficits sick psychotic patients, in order
E-PP1078 to set up a targeted rehabilitation treatment; this will strongly
White matter abnormalities as influence their quality of life
Methods.– It was used a protocol characterized by cognitive tests on
endophenotypes of schizophrenia in a “experimental group” composed of 85 subjects (40% females, 60%
22Q11 deletion syndrome males) with psychotic disorder, that measure the following areas:
M. Frascarelli1* , N. Petsas2 , A. Buzzanca1 , M. Fanella1 , A.M. attention, memory, logical-deductive and problem solving skills.
Monacelli1 , T. Accinni1 , G.M. Lattanzi1 , L. Carlone1 , F. Ghezzi1 , C. The tests given are: Digit Span, Spinnler Matrix Warning, A & B Trail
Colonnese1 , P. Pantano1 , M. Biondi1 , F. Di Fabio1 Making Test, REY’s Auditory Test, F.A.S, Raven’s Color Progressive
1 Sapienza University, Human Neurosciences, Rome, Italy; 2 IRCSS,
Matrices, Clock Drawing Test.
Neuromed, Rome, Italy Results.– On the basis of the results obtained, a significant impair-
* Corresponding author. ment of practical and visual-constructive skills was highlighted. In
particular, the females displayed these cognitive alterations in the
Background and aims.– 22q11.2 Deletion Syndrome (22q11 DS)
age group 21–30 years, while the males had in the age group 31–40.
patients have 25% risk of psychosis onset. White matter (WM) brain
Conclusions.– The results obtained by experimental group demon-
abnormalities are supposed to be endophenotypes of schizophre-
strated the presence of significatealterations related to Practical
nia.
and visual-constructive skills. Acting on these areas, there will be a
Aim of the present study is to compare WM characteristics, namely
rapid and significant recovery of patients with this disorder, accel-
Fractional Anisotropy (FA), an indicator of fibers integrity, between
erating their capacity for autonomy.
groups of schizophrenic and 22q11DS patients to demonstrate they
are similar and present also before the psychotic onset.
interest statement.
Methods.– Sample consists of 83 subjects, divided into 4 groups:
Healthy Controls (HC) N = 24; 22q11DS non-psychotic sub-
jects (DEL) N = 14; 22q11DS psychotic patients (DEL scz) N = 8;
E-PP1080
schizophrenic patients without 22q11DS (SCZ) N = 37. 3T Diffu-
sion Tensor Imaging (DTI) MRI sequences were analysed with Tract The Aripiprazole-Clozapine
Based Spatial Statistic tecnique. Significant results were considered association in treatment ultra
for p < 0.05 corrected for multiple comparisons. resistant schizophrenia: a case report
Results.– SCZ and DEL scz groups showed a significant FA reduc- M. Gharmoul* , J. Nakhli, A. Mtiraoui, S. Ben Nasr
tion compared to HC in identical clusters of voxels, located Farhat Hached University Hospital, Psychiatry Department, Sousse,
in: Corpus Callosum (CC), Fornix, Internal Capsule, Posterior Tunisia
Thalamic Radiation, Inferior and Superior Longitudinal Fasci- * Corresponding author.
culi, Inferior Fronto-Occipital Fasciculus, Uncinate Fasciculus. DEL
group showed a significant FA reduction compared to HC in the Background and aims.– Clozapine remains the reference treatment
sameregions (Internal Capsule, Inferior and Superior Longitudinal in resistant schizophrenia. However, its effectiveness is obtained
Fasciculi, Inferior Fronto-Occipital Fasciculus, Fornix and Uncinate only in 30 to 50% of cases.
Fasciculus) and in the Corona Radiata and External Capsule. The In this clinical case report, we discuss effectiveness of the addi-
only differences between clinical groups consists of a higher FA in tion of Aripiprazole to Clozapine as a therapeutic alternative in the
the CC found in DEL, respect to SCZ group. treatment of ultra-resistant schizophrenia.
Conclusions.– Whole-brain DTI analyses showed similar reduction Methods.– We report the case of Mr A.T, 44 years old. He suf-
of white matter integrity between group at high genetic risk for fers from paranoid resistant schizophrenia since the age of 30
schizophrenia and patients with an established psychotic disorder. years and was treated with 900 mg/day Clozapine without side
The white matter alterations in schizophrenia seems to be linked effects. To evaluate efficacy of treatment, we used the Brief Psychi-
to genetic etiopathogenesis of the disorder. atric Rating Scale (BPRS), the scale for the Assessment of Negative
Disclosure of interest.– The authors have not supplied a conflict of Symptom (SANS) and the scale for the Assessment of Positive Symp-
interest statement. toms (SAPS). Plasma concentrations of Clozapine and the main
metabolite Norclozapine were evaluated by High-Performance Liq-
uid Chromatography method (HPLC).
Results.– Despite the administration of high doses of Clozapine
(900 mg/day), a correct plasma Clozapine concentration and cor-
rect plasma Norclozapine concentration (respectively 824 ng/ml
and 72 ng/ml), we have achieved only 22% improvement in the
BPRS. Finally, when associate Clozapine 900 mg/day to Aripiprazole Background and aims.– Despite the development of successful
at a dose of 10 mg/day, we noted better improvement in positive treatments of psychotic symptoms, the impairment in real-life
symptoms with a marked decrease of anxiety and psychotic symp- functioning in subjects with schizophrenia (SCZs) remains an
toms. In this association we found improvement of 48% in the SAPS, unmet need in their management.
42% in SANS and 40% in BPRS. Recent studies suggested that functioning of SCZs was associated
Conclusions.– The results of this clinical case suggest that the with impairment in mismatch negativity (MMN), an event-related
addition of Aripiprazole to Clozapine in treatment ultra resis- potential reflecting pre-attentive processing. However, these stud-
tant schizophrenia could be an effective therapeutic alternative. ies did not clarify whether this relationship is a direct one or reflects
Double-blind studies are needed to confirm this ascertainment. a cross-correlation with other variables.
Disclosure of interest.– The authors have not supplied a conflict of Our study was designed to investigate differences between SCZs
interest statement. and healthy controls (HCs) on MMN amplitude and its relationships
with real-life functioning domains in SCZs.
Methods.– In the context of a multicenter study of the Italian
E-PP1081 Network for Research on Psychoses, pitch- (p-MMN) and duration-
MMN impairment in subjects with deviant (d-MMN) MMNs were recorded in 125 chronic SCZs and
schizophrenia among different stages 61 HCs. Within SCZs, we assessed psychopathology, neurocogni-
tive functions; functioning was measured with the Specific Level of
of disease
Functioning Scale (SLOF). Multiple regression was used to predict
G.M. Giordano1* , A. Mucci1 , A. Vignapiano1 , G. Di Lorenzo2 , F.
functioning using MMN, age, gender, duration of illness, neu-
Ferrentino2 , A. Bellomo3 , M. Altamura3 , S. Galderisi1
1 University of Campania “Luigi Vanvitelli”, Department of Psychiatry, rocognitive composite score of the MATRICS Consensus Cognitive
Battery, Calgary Depression Scale for Schizophrenia total score,
Naples, Italy; 2 University of Rome “Tor Vergata”, Department of
negative symptom domains of the Brief Negative Symptom Scale,
Systems Medicine, Rome, Italy; 3 University of Foggia, Department of
positive and disorganization dimensions of the Positive and Nega-
Clinical and Experimental Medicine- Psychiatry Unit, Foggia, Italy
tive Syndrome Scale (PANSS) as independent variables.
Results.– SCZs showed a reduced p-MMN and d-MMN amplitudes,
Background and aims.– The mismatch negativity (MMN) is an event- compared with HCs. PANSS Positive dimension (ˇ = −.421, p < .001)
related potential (ERP) associated with pre-attentive processing. and p-MMN amplitude (ˇ = −.219, p < .011) were found to predict
MMN impairment is a well replicated finding in subjects with SLOF work skills domain of SCZs, independently from symptoms,
schizophrenia (SCZs), either in first-episode or chronic patients. demographic characteristics and neurocognition.
However, to date, it is not clear whether this dysfunction reflects Conclusions.– The impairment in the pre-attentive processing in
a feature of the illness or of disease progression and if other vari- SCZs might represent a candidate biomarker of poor functional
ables, such as demographic characteristics, psychopathology and outcome.
cognitive deficits, could have an impact on this impairment. Disclosure of interest.– The authors have not supplied a conflict of
In the context of a multicenter study of the Italian Network for interest statement.
Research on Psychoses, our aim was to investigate the influence of
illness duration on MMN impairment in SCZs.
Methods.– MMNs to pitch- (p-MMN) and duration- (d-MMN) E-PP1083
deviants were recorded in 117 SCZs and 61 healthy controls (HCs). Neurocognitive profile of patients
SCZs were clustered into four groups based on illness duration (ID): with psychotic spectrum disorders
SCZ-A, ID ≤ 5 years (N = 23); SCZ-B, ID 6 to 13 years (N = 38); SCZ- applying methods of computational
C, ID 14 to 18 years (N = 27) and SCZ-D, ID 19 to 32 years (N = 29).
intelligence
We assessed psychopathology and neurocognitive functions. Mul-
E. Gkintoni1* , C. Halkiopoulos2 , P. Gourzis3
tivariate analyses were used to test group differences. 1 University General Hospital of Rio Patras- Greece, University
Results.– SCZ-D exhibited more positive symptoms than SCZ-A
Psychiatric Clinic, Patras, Greece; 2 University of Patras, Business
and higher global neurocognitive deficits than SCZ-A and SCZ-B.
Administration Department, Information Systems and Business
All groups of SCZs, compared with HCs, showed reduced p-MMN
Intelligence Laboratory, Patras, Greece; 3 University of Patras,
(p < .001) and d-MMN (p < .001) amplitudes (age and gender as
University General Hospital of Rio, Patras, University Psychiatric
covariates). We did not find any differences on MMN amplitude
Clinic, Rio, Patras, Greece
among the four SCZ subgroups (age, gender, positive symptoms
and neurocognition as covariates).
Conclusions.– Our results suggest that MMN dysfunction is not Background and aims.– Neurocognitive deficits are a core feature
related to illness duration and is also independent of psychopathol- of psychotic spectrum disorders. It is commonly accepted in the
ogy severity and neurocognitive impairment. scientific psychiatric community that atients who suffer from a
Disclosure of interest.– The authors have not supplied a conflict of particular psychotic disorder, have a variety of deficits in most
interest statement. cognitive functions including executive function, memory and
attention. The purpose of the study is to examine neurocognitive
deficits in a clinical sample of hospitalized patients diagnosed in the
E-PP1082 psychotic spectrum applying innovative methods of computational
Relationship between MMN and intelligence.
real-life functioning in subjects with Methods.– The participants belonged to the category of patients
schizophrenia diagnosed in the spectrum of psychosis disorders hospitalized at
G.M. Giordano1* , A. Mucci1 , A. Vignapiano1 , G. Di Lorenzo2 , F. the University Psychiatric Clinic of the General Hospital. Neuropsy-
Ferrentino2 , A. Bellomo3 , M. Altamura3 , S. Galderisi1 chological tests and scales such as Wisconsin Sorting Card Task, Key
1 University of Campania “Luigi Vanvitelli”, Department of Psychiatry, Search, Stroop Test, Digit Span, and phonological/semantic memory
Naples, Italy; 2 Univeristy of Rome “Tor Vergata”, Department of (COWAT) were used to collect the data.
Systems Medicine, Rome, Italy; 3 University of Foggia, Department of Results.– Through the use of specific computational intelligence
Clinical and Experimental Medicine- Psychiatry Unit, Foggia, Italy programs (WEKA, R), Machine Learning Techniques were applied
* Corresponding author. by selecting appropriate classification, clustering and correla-
tion algorithms. In addition, the parameters of these algorithms Background and aims.– Akathisia remains one of prevalent
were determined, depending on the case, in order to produce drug-induced extrapyramidal manifestations and patients with
conclusions/decision-making rules. schizophrenia are at high risk of its development in psychiatric
Conclusions.– In conclusion, it is underlined the significance of the practice.
exported rules that applied via computational intelligence methods To study incidence rate of akathisia in patients with schizophrenia
and are presented in the most understandable and friendly way to receiving risperidone and olanzapine.
the final recipient. The results of the study highlight the clinical sig- Methods.– 50 patients with schizophrenia receiving atypical
nificance of the neurocognitive deficits of patients (especially in the antipsychotics were examined. 32 (64%) patients received risperi-
executive functions) who are diagnosed in the psychotic spectrum done, 18 (36%) – olanzapine. The groups were matched in sex, age
and may also contribute to a better knowledge for the course of and length of the disease. Assessment of akathisia was performed
the psychosis offering new data for implementation of therapeutic with use of Barnes Akathisia Rating Scale (BARS). Statistical analy-
programs of cognitive rehabilitation/psychoeducation. sis was performed with use of Pearson’s 2 -test, for comparison of
Disclosure of interest.– The authors have not supplied a conflict of small samples the exact Fisher’s criterion was used, for comparison
interest statement. of two independent samples Mann–Whitney U-criterion was used.
Reliability level corresponded to p < 0.05.
Results.– Akathisia incidence rate in the group of patients receiv-
E-PP1084 ing risperidone was 43.7%, with it being significantly higher in
Theory of mind and men (p = 0.009), and also was associated with earlier onset of
psychopathological symptoms in schizophrenia (p = 0.036). In the group of receiving olanzapine it
was 55.6%.
schizophrenia
Conclusions.– The findings show that during receiving the atypical
K. Golebiewska1* , K. Gorna1 , K. Swieca2 , M. Labedzka2 , J. Kiejda1 ,
antipsychotics high prevalence of the development of akathisia is
K. Jaracz3
1 Department of Psychiatric Nursing, University of Medical Sciences, observed therefore use of preventive programs at an early stage of
the course of schizophrenia for the purpose of minimization of the
Poznan, Poland; 2 Department of Adult Psychiatry, University of
risk of its development is of relevance.
Medical Sciences, Poznan, Poland; 3 Department of Neurological
Nursing, University of Medical Sciences, Poznan, Poland
interest statement.
Background and aims.– Theory of Mind means an innate ability

to assign the mental states to oneself and other people. Several E-PP1086
studies have shown a relationship of ToM deficits with various Social cognition and oxidative stress
psychopathological symptoms. So far this matter is not clear. in first decade of schizophrenia: a
The aim of this study was to analyse relationships between ToM 1-year follow-up study
and general clinical symptomatology in schizophrenia. L. Gonzalez Blanco1* , M.P. Garcia-Portilla2 , L. García-Álvarez3 , L.
Methods.– Sixty one patents of schizophrenia were examined at De la Fuente-Tomás3 , F. Dal Santo4 , Á. Velasco5 , J.
admission (Time 1) and before discharge from the psychiatric hos- Rodriguez-Revuelta6 , C. Iglesias7 , P.A. Saiz2 , J. Bobes2
pital (Time 2). ToM was assessed with the Reading the Mind in Eyes 1 University of Oviedo, CIBERSAM - Hospital Universitario Central de
(Time 1: RME1 and Time 2: RME2) by Baron-Cohen at al. (1997). Asturias SESPA, Psychiatry, Oviedo, Spain; 2 University of Oviedo,
Psychiatric symptoms in schizophrenia were assessed using Posi- CIBERSAM - SESPA, Psychiatry, Oviedo, Spain; 3 University of Oviedo,
tive and Negative Syndrome Scale (Time 1: PANSS 1 and Time 2: CIBERSAM, Psychiatry, Oviedo, Spain; 4 Servicio de Salud del
PANSS 2). Principado de Asturias, Psychiatry, Oviedo, Spain; 5 University of
Results.– There were significant differences in clinical symptoms Oviedo, Psychiatry, Oviedo, Spain; 6 University of Oviedo, Hospital
between Time 1 and Time 2: the means (± SD) of the PANSS Universitario Central de Asturias SESPA, Psychiatry, Oviedo, Spain; 7
1 = 112.09 ± 19.48 vs PANSS 2 = 59.21 ± 14.45 (p < 0.001). However, University of Oviedo, SESPA, Psychiatry, Oviedo, Spain
there were no significant differences in symptoms between RME 1 * Corresponding author.
and RME 2: the means (± SD) of the RME 1 = 20.62 ± 5.95 vs RME
2 = 21,21 ± 6.17. There were no significant differences between Background and aims.– There is evidence that cognitive impair-
RME 1 and psychopathological symptoms of PANSS 1. Different ment is related to oxidative stress imbalance in patients with
results appeared in the second study. There were significant differ- schizophrenia or first-episode of psychosis (Moustafa et al., 2014;
ences between RME 2 and negative symptoms (PANSS 2) (p < 0.05). Martínez-Cengotitabengoa et al., 2012). However, there is no lon-
Conclusions.– The relationship between the core symptoms of gitudinal data of this association in social cognition (SC). Aim: To
schizophrenia and the ToM is not clear. Perhaps, study of the analyze the relationship between baseline oxidative stress param-
relationship between particular groups of symptoms will indicate eters and SC.
which symptoms affect the ToM deficits most. Methods.– One-year follow-up study of 54 stable outpatients with
Disclosure of interest.– The authors have not supplied a conflict of schizophrenia (≤10 years of illness) [mean age = 31.3 ± 6.4; 61.1%
interest statement. males]. Assessment: SC was measured with MSCEIT (MATRICS
Cognitive Consensus Battery). Oxidative stress biomarkers: homo-
cysteine, hemolysis test, lipid peroxidation subproducts, catalase
E-PP1085 activity in erythrocytes (CAT). Statistics: Pearson correlation and
Akathisia in patients with linear regression analyses including age, duration of illness, BMI,
schizophrenia receiving risperidone smoking and psychopharmacological treatment as covariates.
Results.– At follow-up, patients presented a worsening (decrease) of
and olanzapine
SC T-score [51.1 ± 16.1 vs 46.9 ± 17.3 (t = 2.434; p = 0.018)]. None of
A. Goncharova* , E. Kornetova
the oxidative stress parameters was significantly correlated with
Mental Health Research Institute, Tomsk National Research Medical
SC at baseline. Only the antioxidant CAT was correlated with the
Center, Russian Academy of Sciences, Department of Endogenous
change of SC T-scores at follow-up (higher levels of CAT associated
Disorders, Tomsk, Russia
with a decrease in T-scores) (r = −0.287; p = 0.035), but not any other
biomarker. Regression model only identified the levels of CAT as a
predictor of worsening in SC [beta = −0.287; R2 = 0.082 (p = 0.035)].
Conclusions.– The oxidative stress mechanisms could be involved University of the Basque Country- National Distance Education
in the deterioration over time of SC in patients with an early stage University UNED, Department of Psychiatry, Vitoria, Spain; 2 Araba
of schizophrenia. In this sense, we found that a greater antioxidant University Hospital- Department of Psychiatry- BioAraba Research
response, as a compensatory response to oxidative damage, was Institute- OSI Araba. Biomedical Research Centre in Mental Health
associated with worsening in SC at 1-year follow-up. Network CIBERSAM- University of the Basque Country, School of
Disclosure of interest.– The authors have not supplied a conflict of Psychology, San Sebastián, Spain; 3 Araba University Hospital-
interest statement. Department of Psychiatry- BioAraba Research Institute- OSI Araba.
Biomedical Research Centre in Mental Health Network CIBERSAM-
National Distance Education University UNED, Psychiatry, Vitoria,
E-PP1087 Spain; 4 Araba University Hospital- Department of Psychiatry-
Delusional disorder beyond the BioAraba Research Institute- OSI Araba. Biomedical Research Centre
dopamine and serotonin hypotheses: in Mental Health Network CIBERSAM, Psychiatry, Vitoria, Spain; 5
Araba University Hospital- Department of Psychiatry- BioAraba
a systematic review supporting
Research Institute- OSI Araba. Biomedical Research Centre in Mental
evidence-to-date Health Network CIBERSAM- University of the Basque Country,
A. González Rodríguez1* , F. Estrada2 , A. Guardia Delgado2 , A. Psychiatry, Vitoria, Spain
Álvarez2 , M. Betriu2 , J.A. Monreal3 , D.J. Palao3 , J. Labad3 * Corresponding author.
1 Corporació Sanitària Parc Taulí- I3PT- CIBERSAM, Mental Health,
Sabadell, Spain; 2 Corporació Sanitària Parc Taulí, Mental Health, Background and aims.– Cannabis use, due to its influence on the
Sabadell, Spain; 3 Corporació Sanitària Parc Taulí- I3PT- CIBERSAM- developmentn and prognosis of the disease, has become a target
UAB, Mental Health, Sabadell, Spain for the prevention and treatment of FEP patients.
* Corresponding author. Cannabis use in FEP is correlated with poor adherence treatment,
the severity of psychotic symptoms, the risk of relapse and poorer
Background and aims.– Disturbances in the dopaminergic and sero- functional outcome at follow-up.
tonergic transmission have been involved in the etiopathogenesis It has been shown that psychoeducation, as an adjuvant to pharma-
and treatment response of psychotic disorders. However, evidence cological treatment, is effective in improving negative symptoms
supporting the dopamine and serotonin hypotheses have not been and functionality. However, there is a need to develop effective spe-
sufficient extended to delusional disorders. cific interventions to reduce cannabis use as part of comprehensive
The main goal of this systematic review was to address the relation- treatment programs for patients with psychosis.
ship between dopamine and serotonin dysfunctions and delusional The objective of the study was to assess the comparative efficacy of
disorder. a cognitive-behavioral treatment program for cannabis use cessa-
Methods.– A systematic computerized search among Pubmed tion (experimental group) in relation to Psychoeducation (standard
and Scopus databases was undertaken for articles from 1990 group) in FEP patients.
to September 2018 following the recommendations of the Pre- Methods.– Patients were randomly assigned to one of the two treat-
ferred Reporting Items for Systematic Reviews and Meta-Analyses ment groups (experimental/standard group) and were assessed
(PRISMA) statement. The following search terms were used: with an assessment protocol for gathering data on clinical, func-
(dopamine OR serotonin) AND (delusional disorder). Retrieved tional and cannabis variables (baseline, post-treatment, 3, 6 and 12
abstracts were screened according to the following criteria: delu- months of follow-up).
sional disorder (ICD, DSM), studies in English, German, French or The effectiveness of both interventions was compared by models
Spanish, reporting a biological measure on dopamine and sero- of repeated measures and logistic regression.
tonin systems, exclusively in delusional disorder. Case reports were Results.– Experimental group patients showed a greater reduc-
excluded. tion in use of cannabis compared to the control group (B = −3,367;
Results.– A total of 579 studies were retrieved, from which 11 were p = ,000), less psychotic symptoms (t = −2.808, p = 0.007), and bet-
included. Dopamine hypothesis (n = 9): (1) Dopamine Receptor D1 ter functionality (t = −2.721, p = 0.008) in the post-treatment. No
(DRD1): no association; (2) DRD2: no association (A/a exon 6 and differences were found in depressive, anxious or manic or symp-
DRD2 Ser311Cys; n = 3) and association (DRD2 Ser311Cys; n = 1); tomatology.
(3) DRD3: association (Ser9Gly; Mscl polymorphism; n = 2); (4) Conclusions.– The intervention focused on the management of
DRD4: association (exon 1, exon 3; n = 2); (5) Dopamine Transporter cannabis use is essential to prevent relapses and to improve the
Gene: no association (n = 1), (6) Tyrosine Hidroxylase: association prognosis of FEP patients.
(n = 1), and (7) pHVA levels: association (n = 1). Serotonin Hypoth- Disclosure of interest.– The authors have not supplied a conflict of
esis (n = 2): Tryptophan hydroxylase gene: no association (A218C, interest statement.
n = 1) and Serotonin Transporter gene: no association (5-HTTLPR;
n = 1).
Conclusions.– Dopaminergic system seems to be linked to delu- E-PP1089
sional disorder, whereas studies on the serotonergic system are
Evidence-based psychoeducational
inconclusive.
Disclosure of interest.– The authors have not supplied a conflict of program in first psychotic episode
interest statement. patients
I. González-Ortega1* , P. Vega2 , J. Fernández3 , A. González-Pinto4
1 Araba University Hospital- BioAraba Research Institute- OSI Araba.
E-PP1088 Biomedical Research Centre in Mental Health Network CIBERSAM-
Cognitive behavioral therapy program University of the Basque Country- National Distance Education
University UNED, Department of Psychiatry, Vitoria, Spain; 2 Araba
for cannabis use cessation vs.
University Hospital- Department of Psychiatry- BioAraba Research
psychoeducation for first-episode Institute- OSI Araba- Biomedical Research Centre in Mental Health
psychosis patients Network CIBERSAM, Psychiatry, Vitoria, Spain; 3 Araba University
I. González-Ortega1* , E. Echeburúa2 , S. Alberich3 , P. Vega4 , A. Hospital- Department of Psychiatry- BioAraba Research Institute- OSI
González-Pinto5 Araba- University of the Basque Country, Psychiatry, Vitoria, Spain; 4
1 Araba University Hospital- BioAraba Research Institute- OSI Araba.
Araba University Hospital- Department of Psychiatry- BioAraba
Biomedical Research Centre in Mental Health Network CIBERSAM- Research Institute- OSI Araba- 2Biomedical Research Centre in
Mental Health Network CIBERSAM- University of the Basque Country, The objective of the present study was to evaluate, in a sample
Psychiatry, Vitoria, Spain of patient with schizophrenia, the efficacy of cognitive rehabilita-
* Corresponding author. tion programs (using the software Cogpack, administered twice a
week for 12 weeks) on the cognitive outcomes, the symptomatol-
Background and aims.– Early psychosocial interventions adjunctive ogy and the real-world functioning, compared to a group subjected
to pharmacotherapy may contribute to symptomatic and func- to standard therapy.
tional recovery of first episode psychosis patients (FEP). Therefore, Methods.– The study was conducted on 41 outpatients between 18
individuals who receive early intervention including guidance on and 65 years old: 16 patients were treated with computer-assisted
how to improve their adherence to treatment, insight into their ill- cognitive remediation therapy (Cogpack) and 25 with standard
ness and self-management, have a better course and, hence, these treatment (TAU). The evaluation included the acquisition of socio-
factors are associated with a better prognosis. demographic and clinical variables of the sample. The following
The objective of the study was to assess the efficacy of a psy- evaluation scales were administered at time zero (T0) and after 12
choeducation programme versus treatment as usual in improving weeks (T1): PANSS for symptomatology, CDSS for negative symp-
the symptomatology and functionality of patients (pre/post- toms, MCCB for cognitive abilities and SLOF for psychosocial global
treatment). functioning. Repeated measures ANOVA test was used for statistical
Methods.– This is a single-blind randomised clinical trial in which analysis.
FEP patients were randomly assigned to one of two treatment Results.– Cogpack showed more statistically significant benefits in
groups: (1) the control group, receiving pharmacotherapy together neuro-cognitive and social-cognitive outcomes than TAU, with bet-
with regular sessions with a psychiatrist (treatment as usual), and ter scores in the scales BACS, LNS, NAB, MSCEIT-ME. Moreover,
(2) the intervention group receiving integrated treatment, namely its effect was significant in the Social Acceptability and Physical
treatment as usual plus a psychoeducational intervention. The psy- functioning subscales of the SLOF.
choeducational programme has 14 sessions focused on improving Conclusions.– Our results suggest the importance of targeted reha-
patient insight into their illness, treatment adherence, prodro- bilitative interventions, to improve cognitive capacities, social
mal identification, early intervention to prevent relapses, healthy cognition and real-world functioning in patients with schizophre-
lifestyles, techniques for managing anxiety, social skills and prob- nia.
lem solving. Patients can also call a telephone helpline between Disclosure of interest.– The authors have not supplied a conflict of
sessions. interest statement.
The improvemente in adherence (Morisky Green Medication
Adherence Scale), psychotic (Positive and Negative Syndrome
Scale), and functionality (Functioning Assessment Short Test) was E-PP1091
analyzed using bivariate analysis, linear and logistic regression Evaluation of polygenic risk score for
models.
Results.– The intervention group presented better functionality
schizophrenia among Northern
(B = 11,024; p = 0,000) and adherence (B = 3,128; p = 0,001) and Finland birth cohort 1966 data
fewer psychotic symptoms (B = −2,002; p = 0,0037) than control T. Nordström* , E. Jääskeläinen, S. Lehto, L. Surakka, J. Miettunen
group in the post-treatment. University of Oulu, Center for Life Course Health Research, Oulu,
Conclusions.– Psychoeducation is effective as a complementary Finland
therapy to pharmacological treatment, improving the evolution of
FEP.
Background and aims.– Psychotic disorders, such as schizophrenia,
are severe mental disorders that affect about 3% of the population.
interest statement.
Generally, the heritability among psychotic disorders is considered
high. Using polygenic risk score (PRS), it is possible to estimate
personal genetic risk.
E-Poster Presentation: Schizophrenia and other The aim of this study is to calculate PRS for schizophrenia and
evaluate it among Northern Finland Birth Cohort 1966 (NFBC1966)
psychotic disorders - Part IX
data.
Methods.– The NFBC1966 is a large longitudinal and still ongoing
birth cohort which consists of more than 12 000 cohort members
E-PP1090 born in 1966 in the Northern Finland.
Cognitive deficits and functioning in The calculation of PRS is based on previous results of genome-wide
schizophrenia: role of association studies on schizophrenia. Information on psychotic
computer-assisted cognitive disorders is based on nationwide registers. Previously found
risk factors (gender, obstetric complications, maternal antenatal
remediation depression, unwantedness of a pregnancy, grand multiparity and
C. Montemagni1* , N. Bracale2 , M. Toye3 , L. Canta3 , P. Rocca2
1 child’s viral central nervous system infection) for psychotic disor-
S.S.D. Coordinamento Assistenziale Psichiatrico Ospedale-Territorio-
ders were used as covariates.
AOU Città della Salute e della Scienza di Torino-Molinette,
Cox regression analysis (Hazard Ratios, HR) was used to estimate
Department of Neuroscience and Mental Health, Torino, Italy; 2
the association between PRS and psychotic disorder. Kaplan-Meier
University of Turin, Department of Neuroscience, Torino, Italy; 3 ASL
survival analysis (Mantel-Cox estimate) was used to estimate the
Torino 3, Dipartimento di salute mentale ASL Torino 3, Torino, Italy
* Corresponding author. incidence of psychotic disorders.
Results.– Genetic data was available from 5 363 (48.2% male;
Background and aims.– The impairment of cognitive performance is 51.8% female) subjects. From them, 3.7% (N = 196) was diagnosed
the most important determinant in the impairment of daily func- with a psychotic disorder. When PRS increased, the risk (adjusted
tioning in patient with schizophrenia. To treat cognitive deficits HR) for psychotic disorder was 2.82-fold (95% confidence inter-
and, in a second time, to act on the functioning of patient with val = 1.55–5.12, p = 0.001). Those who had higher than the mean
schizophrenia, cognitive rehabilitation turned out to be the best PRS were diagnosed with psychotic disorder more previously and
tool available. frequently than the others (Mantel-Cox estimate: 2 = 10.4. df = 1,
p = 0.001).
Conclusions.– PRS for schizophrenia is a sufficient estimate of per- of neurotrophic factors. Changes in expression of those factors are
sonal genetic risk for a psychotic disorder among NFBC1966. considered to be responsible for morphologic abnormalities, as well
Disclosure of interest.– The authors have not supplied a conflict of as for psychopathologic characteristics of schizophrenia.
interest statement. The main goal was to investigate the association between the
level of vitamin D and levels of several nerve growth factors such
as brain-derived neurotrophic factor (BDNF), nerve growth factor
E-PP1092 (NGF) and neuregulin (NRG) and their possible influence on the
Accumulation of ribosomal repeats in psychopathology of schizophrenia.
the schizophrenia patients Methods.– This research included 97 inpatients diagnosed with
schizophrenia during the period of one year. Psychopathology
extracellular DNA is most pronounced
of schizophrenia was assessed by PANSS. Vitamin D was deter-
in catatonic schizophrenia mined using an immunochemical chemiluminescent method with
M. Orlova1* , E. Ershova1 , A. Martynov1 , N. Veiko1 , N. Zakharova2 , (in vitro diagnostic) reagents, while BDNF, NRG1 and NGF growth
A. Filev1 , O. Agafonova1 , P. Umriukhin3 , S. Kostyuk1 factors were determined with the ELISA procedure.
1 Research Centre for Medical Genetics, Laboratory of molecular
Results.– We established that vitamin D levels positively affect
biology, Moscow, Russia; 2 N.A. Alexeev Psychiatric Clinical Hospital NRG1 levels (F = 8.583; p = 0.005) but not the levels of BDNF
No. 1 of Moscow Healthcare Department, Moscow Healthcare and NGF. Furthermore, we did not observe an association
Department, Moscow, Russia; 3 I.M. Sechenov First Moscow State between Vitamin D, BDNF and NGF levels and the symptomatol-
Medical University Sechenov University, Department of Normal ogy of schizophrenia measured by PANSS. However, significant
Physiology, Moscow, Russia association was established between NRG1 levels and positive
symptomatology of schizophrenia (F = 4.927; p = 0.030).
Background and aims.– Schizophrenia (SCZ) is a severe dis- Conclusions.– Vitamin D levels might indirectly influence
abling disease. Oxidative stress plays an importantrole in the schizophrenia symptomatology through its established direct asso-
SCZ pathogenesis, causing DNA oxidative modifications and dam- ciation with NRG1 levels, which have been found to significantly
age. Oxidative stress results in blood cells dying leading to the affect positive symptoms of schizophrenia.
increase of cell-free DNA(cfDNA) level in circulation. The cfDNA Disclosure of interest.– The authors have not supplied a conflict of
characteristics in SCZ patients are poorlyinvestigated. Presumably, interest statement.
accumulation of GC-rich cfDNA may lead toproinflammatory sig-
naling pathways activation.
E-PP1094
Methods.– 54 patients with paranoid schizophrenia in a remission
under standard therapy and 46catatonic schizophrenia patients Multi-center validation of the
were included in the study. The group of healthydonors included 80 Russians version of the diagnostic
people. G0-lymphocytes were isolated from the peripheral bloodby interview for psychoses
density gradient on Ficoll-Urografin. Phosphorylated histone H2AX D. Smirnova1 , Y. Osadshiy2* , N. Petrova3 , A. Pavlichenko4 , I.
expressionwas determined by flow cytometry. Nonradioactive Martynikhin5 , M. Dorofeikova6 , I. Fedotov7 , D. Ubeikon8 , A.
quantitative hybridization withbiotinylated rDNA probes was used Yashikhina9 , A. Jablensky1
for rDNA CN evaluation. 1 University of Western Australia, Centre for Clinical Research in
Results.– Schizophrenia patients’ lymphocytes contain elevated Neuropsychiatry, Perth, Australia; 2 Rostov on Don State Medical
amounts of H2AX histone (p < 0.01). Double-strand breaks num- University, psychiatry, Volgograd, Russia; 3 St. Petersburg State
ber was higher in patients with catatonicschizophrenia compared University, psychiatry, St. Petersburg, Russia; 4 Evdokimov Moscow
with paranoid schizophrenia (p < 0.01). In catatonicschizophrenia State University of Medicine and Dentistry, psychiatry, Moscow,
patients the number of cfDNA rDNA copies was higher compared Russia; 5 Pavlov First St. Petersburg State Medical University,
withparanoid schizophrenia (p < 0.01). The number of cfDNA - rDNA psychiatry, St. Petersburg, Russia; 6 Bekhterev St. Petersburg
repeats in catatonicschizophrenia patients was higher compared Psychoneurological Research Institute, Psychoneurological, St.
with control (p < 0.01). The number ofrDNA copies in paranoid Petersburg, Russia; 7 Ryazan State Medical University, psychiatry,
schizophrenia patients was similar to the control. Ryazan, Russia; 8 Vernadsky Crimea Federal University, psychiatry,
Conclusions.– Higher levels of DNA damage and rDNA in cfDNA were Simferopol, Russia; 9 Samara State Medical University, psychiatry,
found in catatonicschizophrenia patients. Samara, Russia
interest statement.
Background and aims.– There is still no absolute agreement among
psychiatrists around the world regarding diagnostic criteria for
E-PP1093 schizophrenia and other psychotic disorders. The Diagnostic Inter-
Relationship between vitamin D and view for Psychoses (DIP) is used in many countries as the tool for
diagnostic psychotic disorders.
nerve growth factor concentrations
The aim of the study was the adaptation of the Russian language
and its influence on schizophrenia version and evaluation of its validity and reliability.
symptoms expression Methods.– Ninety-eight patients with psychotic disorders were
I. Orlović1* , K. Jurčević Požega2 , M. Peco3 , V. Peitl3 , D. Karlović3 assessed by 7 interviewers using the Russian version of DIP.
1 –
Institute of Public Health- Medimurje county, Mental health care The inter-rater reliability (32 randomized cases) was compared
and addiction prevention, Čakovec, Croatia; 2 Neuropsychiatric with the researchers’ DIP ratings. Overall pairwise agreement and
Hospital “Dr. Ivan Barbot”, Psychiatry, Popovača, Croatia; 3 Cohen’s kappa were calculated. Diagnostic validity was evaluated
University Clinical Hospital Center “Sestre Milosrdnice”, Psychiatry, on the basis of comparing the researchers’ ratings using the Russian
Zagreb, Croatia version of DIP with the ‘gold standard’ ratings of the same 62 clinical
cases from the Western Australia Family Study Schizophrenia.
Results.– The Kappa statistic demonstrated level of agreement on
Background and aims.– Although biological roles of Vitamin D
the majority of DIP items (84.54%) and a significant agreement for
seem to be numerous, amongst its most important ones are
the ICD-10 diagnoses generated by the DIP computer diagnostic
those involved in brain development/functioning and regulation
algorithm ( = 0.68; 95% CI 0.53,0.93). The level of agreement on
the researchers’ diagnoses was considerably lower ( = 0.31; 95% Background and aims.– Introduction:Sexual dysfunction is a com-
CI 0.06,0.56). The agreement on affective and positive psychotic mon side effect of antipsychotic medication and has the potential
symptoms was significantly higher than agreement on negative to increase medication nonadherence, especially in young people1 .
symptoms (F(2,44) = 20.72, p < 0.001, 2 = 0.485). The diagnostic Objectives.– The main objective of this study was to determine the
validity of the Russian language version of DIP was confirmed by prevalence of sexual dysfunction in young schizophrenic patients
73% of the Russian DIP diagnoses. treated with paliperidone palmitate 3-month formulation (PP3M).
Conclusions.– The results of the study confirm the validity and reli- Methods.– 12 outpatients younger than 35 (9 male and 3 female)
ability of the Russian version of the DIP for evaluating psychotic were recruited. They met the DSM 5 schizophrenia criteria. They
disorders. were being treated with PP3M in antipsychotic monotherapy and
Disclosure of interest.– The authors have not supplied a conflict of without changes in pharmacological treatment in the last 4 months.
interest statement. We used the Psychotropic Related Sexual Dysfunction Question-
naire (PRSexDQ) to assess the sexual dysfunction. The overall score
ranges from 0 (no sexual dysfunction) to 15 points (maximum sex-
E-PP1095 ual dysfunction).
Facial affect recognition in subjects Results.– The prevalence of mild and moderate sexual dysfunction
with a diagnosis of schizophrenic was 33.3% (4 patients) and 16.6% (2 patients), respectively. Among
those with mild sexual dysfunction, 100% accepted this sexual dys-
versus schizoaffective disorder
function well, did not interfere in their relationship, and had not
I. Papava1* , A.L. Panfil2 , C. Bredicean1 , L. Dehelean1 , V.R.
thought of discontinuing treatment. However, those patients who
Enatescu1 , R. Romosan1 , A.M. Romosan1 , C. Giurgi-Oncu1
1 University of Medicine and Pharmacy “Victor Babes ”, Department had moderate sexual dysfunction, 50% did not accept this sexual
,
dysfunction well, and thought about quitting treatment. The preva-
of Neuroscience - Discipline of Psychiatry, Timisoara, Romania; 2
lence of sexual dysfunction was higher in those patients who were
University of Medicine and Pharmacy, Psychiatry, Targu Mures,
under treatment with pharmacological polytherapy.
Romania
* Corresponding author. Conclusions.– In our study we found that only moderate sexual
dysfunction had an impact on adherence to treatment. The low
Background and aims.– Facial affect recognition is impaired in sev- prevalence of moderate sexual dysfunction that we found in our
eral psychiatric disorders. This aspect was extensively studied in sample, makes us think that this may be another reason to enhance
subjects suffering from psychotic and depressive disorders, but the adherence of patients treated with PP3M.
few studies tried to explore the differences between the distinctive Disclosure of interest.– The authors have not supplied a conflict of
psychoses. interest statement.
This study aimed to explore the differences in facial affect recog-
nition between two types of categorical psychoses (subjects with
schizophrenics versus schizoaffective disorder diagnosis). E-PP1097
Methods.– In this cross-sectional study 25 subjects were enrolled Analysis of prosocial networks in
in each lot. The first lot was form from subjects with a diagnosis of patients with schizophrenia
Schizophrenia and the second with a diagnosis of Schizoaffective N. Pshuk1* , M. Markova2 , Y. Martynova1
Disorder, using ICD-10 classification system. All subjects were, at 1 National Pirogov Memorial Medical University- Vinnytsya, Medical
least, in partial remission when evaluated. They were evaluated Psychology and Psychiatry Department with the Course of
with a tool used for identification of universal emotions: anger, fear, Postgraduate Education, Vinnytsya, Ukraine; 2 Kharkiv Medical
sadness, disgust, surprise and happiness, based on POFA (Picture of Academy of Postgraduate Education, Department of Sexology-
Facial Affect). Medical Psychology- Medical and Psychological Rehabilitation,
Results.– Happiness and surprise were the most recognized emo- Kharkiv, Ukraine
tions in both lots. Fear was the least recognized emotion in * Corresponding author.
schizophrenic lot, and disgust in schizoaffective lot. Between the

two lots there were significant differences (p < 0,05) in identifica- Background and aims.– Process of social support plays a key role
tion of all basal emotions, except disgust. These emotions (except in overcoming stressful and problematic situations and increases
disgust) were better recognized by the subjects with schizoaffective effectiveness of treatment for patients with schizophrenia.
disorder. We examined 168 patients with paranoid schizophrenia (97 men
Conclusions.– Although we have two schizophrenic spectrum psy- and 71 women) aged 23 to 45 years (34,1 ± 0.8 years on average).
choses, clinically similar, we found that the impairment in facial Duration of observation was 2,7 years on average.
emotion recognition differs significantly between lots. Methods.– Study of social support perception was carried out using
Disclosure of interest.– The authors have not supplied a conflict of the Multidimensional Scale of Perceived Social Support (MSPS) by
interest statement. G. D. Zimet.
Results.– Main social support networks, as factor of psychoso-
cial therapy, are often family, friends, significant others. 55,9% of
E-PP1096 patients live in paternal family, where permanent conflict situa-
Paliperidone palmitate 3-month tions and family neuroticism, as well as violations of psychological
adaptation, are present. 64,9% of patients did not consider social
formulation and sexual dysfunction in
network of “family” to be a source of social support. Social net-
young schizophrenic patients work of “friends” in patients with schizophrenia was insignificant
B.O. Plasencia García De Diego1* , S.L. Romero Guillena2 , F. Gotor (26.2%), mainly due to disintegrative behavior of patients with emo-
Sanchez-Luengo3 tional and voluntary disorders. Lack of affiliative personality traits
1 Hospital de la Merced, Psychiatry, OSUNA, Spain; 2 Hospital
did not motivate patients to form friendly alliances. Social network
Universitario Virgen Macarena, Psychiatry, Sevilla, Spain; 3 Hospital of “friends” as a structure of social support process, in fact, was
Nuestra Señora de Valme, Psychiatry, Sevilla, Spain devaluated. In social network of “significant others” in patients with
schizophrenia, wife (28.6%), mother (39.8%), father (20.2%), hus-
band (11.3%) were determined as donors of social support. Patients
showed understanding that their own destiny in the future depends
on help of “significant others”, so they tried to find compromises in School of Medicine, Ankara, Turkey; 6 Chonnam National University
interpersonal relations. Medical School, Department of Psychiatry, Gwangju, Republic of
Conclusions.– Revealed features can be used while develop- Korea; 7 Janssen-Cilag B.V., Biometrics Medical Affairs EMEA, Breda,
ing algorithms of psychoeducational programs for patients with The Netherlands; 8 Johnson & Johnson, EMEA Medical Affairs
schizophrenia and their referential relatives. Organization, Moscow, Russia; 9 Janssen Cilag, EMEA Medical Affairs,
Disclosure of interest.– The authors have not supplied a conflict of Issy-les-Moulineaux, France; 10 Janssen Cilag, EMEA Medical Affairs,
interest statement. Dusseldorf, Germany
E-PP1098 Background and aims.– REMISSIO was a prospective, single-arm,

Features of social support perception open-label, 52-week study conducted assessing effectiveness of
paliperidone 3-monthly formulation (PP3M) in clinically stable
in patients with schizophrenia
schizophrenia patients in a naturalistic setting. This analysis exam-
N. Pshuk1* , Y. Pshuk2
1 National Pirogov Memorial Medical University- Vinnytsya, Medical ined caregiver burden.
Methods.– Patients with schizophrenia (age 18–50 years) were eli-
gible if adequately treated with PP1M ≥4 months with a baseline
Postgraduate Education, Vinnytsya, Ukraine; 2 Vitos-Klinik fur
Positive and Negative Syndrome Scale (PANSS) total score <70.
Psychiatrie und Psychotherapie- Herborn, Station 7, Herborn,
Primary study outcome was the number of patients achieving
Germany
* Corresponding author. symptomatic remission (SR) [Andreasen NC et al. Am J Psychia-
try. 2005:162;441–449] at last observation carried forward (LOCF);
Background and aims.– Improving the effectiveness of treatment for secondary outcomes included caregiver burden, measured by the
schizophrenia patients involves combined effect of psychopharma- Involvement Evaluation Questionnaire (IEQ).
cotherapy and psychosocial therapy. As the latter ability of patients Results.– 159 caregivers completed ≥1 section of the IEQ. Of female
with schizophrenia to perceive social support may be considered. participants, 61% had a male caregiver; of male participants, 61% a
This integrated indicator shows priority relations with representa- female caregiver. For participants with a caregiver, mean baseline
tives of society (family, friends, significant others). PANSS total score was 4.7 points higher; Personal and Social Per-
Aim.– Analysing characteristics of patients with paranoid formance score 4.2 points lower. Most participants (74.8%) were
schizophrenia in terms of their ability to perceive social support. part of the caretaker’s household; 54.1% of caregivers had >32
Methods.– We examined 168 patients with paranoid schizophrenia hours/week contact with the relative/friend at baseline. 52.2% of
(97 men and 71 women) aged 23 to 45 years (34.1 ± 0.8 years on caregivers were parents, 16.4% partners/spouses, 15.1% siblings. At
average). Study of social support perception was conducted using baseline, mean (SD) IEQ total score was fair-to-moderate reducing
the Multidimensional Scale of Perceived Social Support (MSPSS) significantly at LOCF endpoint by −4.02 (95%CI: −5.9, −2.1) points.
[Zimet, 1998]. Most improvement from baseline at LOCF endpoint was observed
Results.– According to “Family” subscale only 47 (27.9%) patients in the urging domain (mean change: −1.99 [95%CI: −2.9, −1.1]), fol-
showed a 100% degree of expressiveness of social support per- lowed by worrying (−1.65 [95%CI: −2.3, −0.9]), supervision (−1.12
ception; 54 (32.1%) patients - 75%; 29 (17.3%) patients - 50% and [95%CI: −1.7, −0.5]), and tension (−0.3 [95%CI: −0.9, 0.3]) domains.
10 (5.9%) - 25% of expressiveness. As for “Friends” subscale, only Conclusions.– Outcomes indicate that continued treatment of an
33 (19.6%) patients experienced 100% degree of expressiveness of already stable patient population with PP3M can significantly
social support perception; 49 (29,1%) patients - 75%; 35 (20.8%) reduce the burden of their caregivers.
patients - 50% and 51 (30.4%) - 25% expressiveness of the sign. Disclosure of interest.– The authors have not supplied a conflict of
According to “Significant other” subscale 37 (22.0%) of patients interest statement.
showed 100% perception of social support; 66 (39.3%) patients -
75%; 42 (25.0%) - 50% and 23 (13.7%) patients - 25% expressiveness
of the sign. E-PP1100
Conclusions.– Ability to perceive social support in patients with The effectiveness of metacognitive
schizophrenia depends on degree of expressiveness of obligatory training for psychosis (MCT) in the
symptoms of schizophrenic round (autism, apathy, ambivalence), ultra-high risk group (UHR)
even disintegrative behavior with emotional and volitional flat- K. Rek-Owodziń* , K. Waszczuk, P. Plichta, J. Kucharska- Mazur, J.
tening. Revealed features can be used to develop appropriate Samochowiec
psychoeducational programs. Pomeranian Medical University, Department and Clinic of Psychiatry,
Disclosure of interest.– The authors have not supplied a conflict of Szczecin, Poland
Background and aims.– Medicine needs a constant development.

E-PP1099 Innovative ideas and researches in psychiatry shapes proper
Stable schizophrenia patients approach to the patients. Schizophrenia, serve neurodevelopmen-
switched to paliperidone palmitate tal disorder, is still one of the biggest diagnostic and therapeutic
challenge. It affects life of the patients significantly, influencing
3-monthly formulation in real life:
ability to work and live independently. Fast diagnosis and start of
impact on caregiver burden the treatment improves prognosis and makes life of the patients
G. Maina1 , M.P. Garcia-Portilla2 , P.M. Llorca3 , V.P. Bozikas4 , H. more comfortable. That’s why many of current researches are
Devrimci-Ozguven5 , S.W. Kim6 , P. Bergmans7 , V. Strulev8 , P. focused on group of ultra-high risk patients. There are reports that
Cherubin9 , K. Pungor10* CBT itself or combined with the psychopharmacology is effective in
1 AOU San Luigi Gonzaga Università degli Studi di Torino, SCDU
reducing prodromal symptoms or even stopping the development
Psichiatria, Turin, Italy; 2 CIBERSAM, University of Oviedo, Oviedo, of a full-blown schizophrenia. Despite that it is still an expensive
Spain; 3 Clermont Auvergne University, CMP-B CHU Clermont and difficult to access method of treatment. Data shows that the
Ferrand, Clermont Ferrand, France; 4 Aristotle University of group form of therapy, Metacognitive Training, is effective in the
Thessaloniki School of Medicine, Second Department of Psychiatry, reducing some symptoms of schizophrenia.
Thessaloniki, Greece; 5 Ankara University, Department of Psychiatry-
Aim.– The appliance of MCT might be effective in reducing the E-PP1102

symptoms and preventing the development of a full-blown disease Personal-stigma in patients diagnosed
in the UHR group.
with schizophrenia
Methods.– 200–300 people in UHR state (diagnosed with Structured
J. Sevilla-Llewellyn-Jones1 , B. Reneses1* , R. Vila-Badia2 , T.
Interview for Prodromal Symptoms) before and after the MCT are
Palomo3 , M. Pereira1 , M.J. Regatero1 , S. Ochoa2
diagnosed with: STAI (State-Trait Anxiety Inventory), CISS (Cop- 1 Clínico San Carlos Hospital, Psychiatry, Madrid, Spain; 2 Parc
ing Inventory for Stressful Situations) and MATRICS (Consensus
Sanitari Sant Joan de Deu, Research and Development Unit,
Cognitive Battery).
Barcelona, Spain; 3 Complutense University, Psychiatry, Madrid,
Results.– We await that participation in MCT will reduce prodromal
Spain
symptoms and level of anxiety in UHR group. We assume that it will * Corresponding author.
improve cognitive functions (operative memory, executive func-
tions, efficiency of attention) and help to develop more successful Background and aims.– People with a diagnosis of schizophrenia are
methods to cope with stress. one of the most stigmatized groups in society. Our objective was
Conclusions.– MCT might become an effective method of treatment to comprehensively analyze personal stigma in patients diagnosed
and support in UHR state. with schizophrenia.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Data were obtained from 89 patients. Patients were
interest statement. assessed with: a sociodemographic and clinical questionnaire,
the Discrimination and Stigma Scale, the Self-perception of
Stigma Questionnaire for People with Schizophrenia, the Positive
E-PP1101 and Negative Syndrome Scale, the Calgary Depression Scale for
Extrapyramidal and depressive Schizophrenia, the Global Assessment of Functioning Scale, and the
symptoms in first-episode psychosis Brief Social Functioning Scale.
during amisulpride treatment- the Results.– 29.5% of the experienced stigma subscale variance was
explained by age of onset and level of depression. 20.1% of the
results of optimise study anticipated stigma subscale variance was explained by level of
A. Remlinger-Molenda1* , W. Roszka2 , J.K. Rybakowski1
1 depression and gender. 27.3% of the overcoming stigma subscale
University of Medical Sciences, Department of Adult Psychiatry,
variance was explained by level of depression and positive and neg-
Poznan, Poland; 2 University of Economics and Business, Department
ative psychotic symptoms. 35.8% of the self-stigma scale variance
of Statistics, Poznan, Poland
* Corresponding author. was explained by the level of depression.
Conclusions.– Personal stigma seems to be better explained by clin-
Background and aims.– ical dimensions, especially depression.
Introduction.– The first phase of the OPTIMISE study is a four-week Disclosure of interest.– The authors have not supplied a conflict of
treatment of first-episode psychotic patients with amisulpride. interest statement.
Objectives.– The aim was to assess extrapyramidal and depressive
symptoms in these patients before and after amisulpride treatment.
E-PP1103
Methods.– The study involved 441 patients, 311 male, aged
25.2 + 5.2 years and 130 female, aged 26.9 + 6.6 years, with a pre- Quality of life in recent onset of
vious use of antipsychotic drugs of less than 2 weeks during the psychosis patients
preceding year and less than 6 weeks lifetime. Extrapyramidal J. Sevilla-Llewellyn-Jones1 , B. Reneses1* , P. Cano2 , A.
symptoms were assessed by the UKU Side Effect Rating Scale and De-Luis-Matilla2 , A. Espina2 , S. Ochoa3
depressive symptoms were estimated by the Calgary Depression 1 Clínico San Carlos Hospital. Complutense University, Department of
Scale for Schizophrenia (CDSS). Psychiatry. Biomedical Research Institute., Madrid, Spain; 2 Hospital
Results.– In 66,8% patients, the response to treatment was noted. At Clinico Virgende la Victoria, Mental Health, Malaga, Spain; 3 Parc
baseline, the frequency of extrapyramidal symptoms was: akathisia Sanitari Sant Joan de Deu, Research and Development Unit,
14.5%; tremor 14.3%; akinesia 11.3%; rigidity 11.1%, dystonia 9.5%; Barcelona, Spain
hyperkinesia 3.9%. Some of them were more marked in women. * Corresponding author.
There were no significant changes after amisulpride in respon-

ders to treatment, however, in non-responders, the frequency Background and aims.– Interest in Quality of Life (QoL) has been
of akathisia, tremor, akinesia and rigidity significantly increased. on the increase in the last couple of decades. Subjective QoL in
The mean CDSS score at baseline was 4.5 + 4.6, correlated with psychosis is influenced by different factors such as psychosocial,
the intensity of most extrapyramidal symptoms, and significantly personality self-factors and psychopathology. Our objectives were
decreased after treatment (2.8 + 3.8), more so in responders than in to study the effect that psychosocial, personality and clinical char-
non-responders. acteristics had on subjective Quality of Life (QoL) in recent onset of
Conclusions.– The results suggest the relatively high intensity of psychosis patients (ROP).
extrapyramidal and depressive symptoms before treatment in Methods.– Data for these analyses were obtained from 81 ROP
these patients. After treatment in responders, no change in fre- patients. The Millon Clinical Multiaxial Inventory, the Positive and
quency of extrapyramidal symptoms and significant decrease of Negative Syndrome Scale and the World Health Organization Qual-
depressive symptoms was noted. In non-responders, there was an ity of Life Brief Scale (WHOQoL) were used to assess personality,
increase in extrapyramidal and less decrease of depressive symp- symptoms and QoL.
toms. Results.– Considering the different domains of subjective QoL mea-
Disclosure of interest.– The authors have not supplied a conflict of sured by the WHOQoL our results showed that (i) 16.9% of the
interest statement. physical domain was explained by negative symptoms and narcis-
sistic and depressive personality traits (ii) 15% of the psychological
domain was explained by narcissistic and depressive personality
traits (iii) and finally, 13.7% of the social domain was explained by
negative psychotic symptoms and histrionic personality traits.
Conclusions.– Personality traits seem to play an important role in
subjective QoL. Therefore, our results support the importance of
integrated intervention approaches.

interest statement. Use of paliperidone palmitate
3-month formulation in clinical
E-PP1104 practice: an extended study
S.L. Romero Guillena1* , B.O. Plasencia Garcia de Diego2 , F. Gotor
Could unsaturated fatty acids affect
Sanchez-luengo3 , M. Garcia Salguero1
cognitive performance? The 1 U.S.M.C Carmona. UGC Salud Mental Virgen Macarena, psychiatry,
relationship between polyunsaturated Sevilla, Spain; 2 De la Merced Hospital, psychiatry, Osuna, Spain; 3
omega-6 fatty acids and executive Nuestra Señora de Valme Hospital, Psychiatry, Sevilla, Spain
function in schizophrenia patients
and healthy controls Background and aims.– Paliperidone Palmitate 3-month formula-
J. Rog1* , E. Stelmach2 , D. Juchnowicz3 , M. Dzikowski1 , A. tion (PP3M) shows a significantly longer time to relapse compared
Korzeniowska4 , J. Morylowska-Topolska5 , A. Ludwiczuk6 , A. to placebo, and was non inferior to one-month formulation in terms
Błażewicz7 , P. Niziński7 , M. Karakuła8 , H. Karakula-Juchnowicz1 of efficacy and safety. However, studies of longer duration are
1 Medical University of Lublin, 1st Department of Psychiatry-
required. The aim of this study was to determine the effectiveness,
Psychotherapy and Early Intervention, Lublin, Poland; 2 Medical safety and tolerability of the PP3M in outpatients with non-acute
University of Lublin, 2nd Department of Psychiatry and Psychiatry schizophrenia
Rehabilitation, Lublin, Poland; 3 Medical University of Lublin, Methods.– 30 outpatients with diagnosis of schizophrenia (DSM 5)
Department of Psychiatric Nursing, Lublin, Poland; 4 Independent that started treatment with PP3M were recruited.
Public Clinical Hospital No. 1, Psychiatric Outpatient Department, On a tri-monthly basis, during a follow-up period of 24 months,
Lublin, Poland; 5 Medical University of Lublin, Department of Clinical were performed:
Neuropsychiatry, Lublin, Poland; 6 Medical University of Lublin, - Positive and Negative Syndrome Scale (PANSS)
Department of Pharmacognosy with Medicinal Plant Unit, Lublin, - UKU Side Effect Scale
Poland; 7 Medical University of Lublin, Department of Analytical - Patient Satisfaction with Medication Questionnaire (PSMQ)
Chemistry, Lublin, Poland; 8 Medical University of Lublin, Student - Personal Social Performance Scale (PSP)
Research Group at the Department of Analytical Chemistry, Lublin, Efficacy values.– Percentage of patients who remained relapse free
Poland at the end of the 24 months (as defined by Csernansky).
Results.– 93.3% of patients remained relapse free at the end of the
study.
Background and aims.– The membrane hypothesis links schizophre-
Mean variations from baseline scores at 24 months were
nia with abnormalities in the metabolism of phospholipids and
(−3.1 ± 3.6) on the PANSS and (4.11 ± 2.67) on the PSP scale.
PUFAs. Excessive blood levels of omega-6 and higher ratios of
A not significant increase was found in the number of patients
omega-6/omega-3 PUFAs could promote low-grade inflammation
reporting to be “extremely satisfied” or “very satisfied” with their
and brain-related dysfunction.
medication (PSQM) (80% at baseline vs. 86.66% at 24 months)
We examined schizophrenic patients and healthy controls with
The rate of adherence to treatment with PP3M after 24 months was
the aim of (1) assessing the plasma level of arachidonic acid
90%.
(AA) omega-6 PUFA, and (2) exploring the relationship between
Tolerance to PP3M was high, and none of the patients discontinued
AA with executive function and psychopathological symptoms in
their treatment due to adverse effects.
schizophrenia.
Conclusions.– We found that long-term treatment with Paliperi-
Methods.– The sample comprised 84 participants (56 patients who
done Palmitate 3-month formulation is effective, safe and well
fulfilled DSM-5 criteria for schizophrenia and 29 healthy controls).
tolerated in clinical practice conditions.
Their plasma concentrations and daily food intake of AA were
quantified. The Trail Making Test (TMT) was performed to asses
interest statement.
executive function. PANSS scale was used to evaluate psychopatho-
logical symptoms in the patient group.
Results.– There was a relationship between TMT (part B) and AA E-PP1106
plasma concentrations, moderate (p < 0.05; r = 0.52) in healthy indi-
viduals, and strong (p < 0.05; r = 0.90) in patients. In the patient Prevalence of sexual dysfunction in
group, AA plasma levels were correlated with the severity of neg- young schizophrenic patients treated
ative symptoms (p < 0.05; r = 0.32), especially with a poor rapport with aripiprazole one-monthly
and uncooperativeness. TMT (part B and the sum of part A&B) was S.L. Romero Guillena1* , F. Gotor Sanchez-luengo2 , B.O. Plasencia
positively correlated with blunted affect, motor retardation and Garcia de Diego3
poor attention. The study groups did not differ in AA plasma levels 1 U.S.M.C Carmona. UGC Salud Mental Virgen Macarena, psychiatry,
or PUFA intake. Sevilla, Spain; 2 Nuestra Señora de Valme Hospital, psychiatry,

Conclusions.– The results suggest that AA blood level may play an Sevilla, Spain; 3 De la Merced Hospital, psychiatry, Osuna, Spain
important role in cognitive performance, especially in persons with * Corresponding author.
schizophrenia. Investigation of PUFAs levels and their metabolism

could provide an opportunity for some schizophrenia patients to Background and aims.– One of the main causes of discontinuation of
benefit from more personalized medicine. antipsychotic treatment is sexual dysfunction, especially in young
Disclosure of interest.– The authors have not supplied a conflict of people.
interest statement. The main aim of this study was to determine the prevalence of
sexual dysfunction in young schizophrenic patients treated with
Arpiprazole One-Monthly (AOM)
Methods.– 12 outpatients younger than 35 (8 male and 4 female)
were recruited. They met the DSM 5 schizophrenia criteria. They
were being treated with AOM in antipsychotic monotherapy and
without changes in pharmacological treatment in the last 4 months.
We used the Psychotropic Related Sexual Dysfunction Question- E-PP1108

naire (PRSexDQ) to assess the sexual dysfunction. The overall score Vulnerability to stress in the first
ranges from 0 (no sexual dysfunction) to 15 points (maximum sex-
episode psychosis – preliminary
ual dysfunction).
Results.– The prevalence of mild and moderate sexual dysfunction
results of the prospective study
was 25% (3 patients) and 8.3% (1 patient), respectively. Among those L. Rossini Gajsak1* , M. Boskovic1 , M. Celic Ruzic2 , V. Ermakora1 , A.
with mild sexual dysfunction, 100% accepted this sexual dysfunc- Koricancic Makar3 , M. Rojnic Kuzman3
1 Neuropsychiatric Hospital “Dr. Ivan Barbot”, Department of
tion well, did not interfere in their relationship, and had not thought
of discontinuing treatment. Biological Psychiatry, Popovaca, Croatia; 2 Psychiatric Hospital “Sveti
The prevalence of sexual dysfunction was higher in those patients Ivan”, Centre for Integrative Psychiatry, Zagreb, Croatia; 3 University
who were under treatment with pharmacological polytherapy. Clinical Hospital Centre Zagreb, University Psychiatric Clinic, Zagreb,
Conclusions.– The prevalence of moderate sexual dysfunction Croatia
in young schizophrenic patients treated with Arpiprazole One-
Monthly was less than 10%. The low prevalence of sexual Background and aims.– Current findings suggest that changes of
dysfunction with this long-acting injectable enabled to achieve the hypothalamus-pituitary-adrenal (HPA) axis might be present
higher adherence rates in patients with first episode psychosis disorders.
Disclosure of interest.– The authors have not supplied a conflict of Our aims were to assess the difference in response to psychoso-
interest statement. cial stress between First Episode Psychosis (FEP) patients in acute
episode versus FEP patients in the phase of stabile remission.
Methods.– In the present study 45 FEP antipscyhotics naive patients
E-PP1107
were assessed using structured clinical psychiatric interviews,
Long-acting injectable aripiprazole: psychotic symptoms were assessed using Positive and Negative
real world effectiveness. A 6-month Symptoms Scale (PANSS), recent stress through Life Events Ques-
follow up tionnaire (LEQ) and for biochemical assessment, samples of blood
R. Romero* , M. Gómez Revuelta, O. Porta Olivares, F. Román Rubio, for cortisol, prolactin and insulin as well as samples of saliva for
S. Somonte Segares, P. Suárez Pinilla, M. Fernández Rodríguez, A.B. cortisol in both research phases. All participants were exposed to
Pérez Santos, B. Fernández-Abascal Puente the Trier Social Stress Test (TSST).
Hospital Universitario Marqués de Valdecilla, Department of We have analyzed distribution of frequencies between the groups
Psychiatry, Santander, Spain for categoric variables through chi square test.
* Corresponding author. Results.– Our findings indicate a differences between patients in
different research phases of salivatory cortisol measured in 5 time
Background and aims.– Schizophrenia is a chronic disease with points during the TSST.
periods of remission and relapse. Antipsychotic drugs represent Conclusions.– Findings of our research support the correlations of
the mainstay of treatment for this disease. Long-acting injectable exposure to chronic stress with onset of the FEP. In research and
antipsychotics are an attractive alternative to their oral coun- clinical settings it would be useful to be able to identify these vul-
terparts, since they increase patient adherence (1). Long-acting nerable patients in order to prevent deterioration.
injectable aripiprazole (A-LAI) is the last active principle available This work was funded by the grant of the Croatian Science Foun-
in our country and its evidence is still limited. The objective is dation No UIP-2014-09- 1245 “Biomarkers in schizophrenia –
to determine the clinical efficacy and effectiveness of a sample of integration of complementary methods in longitudinal follow up
patients diagnosed with schizophrenia during a six-month follow- of first episode psychosis patients”.
up. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– In our sample, 56 patients were recruited from two men- interest statement.
tal health devices in Santander area in Spain. All of them, under
diagnosis of Schizophrenia and in conditions of clinical stability.
Clinical efficacy measures (BPRS, SAPS, SANS, CGI), discontinuation E-PP1109
rate and mean time to discontinuation due to any cause (effective- Mobilization of peripheral blood stem
ness), quality of life (QLS), and secondary effects profile (UKU, BAS,
cells and changes in the concentration
SARS), were evaluated over six months.
Results.– Concerning CGI scale, 85.2% of patients showed a similar of plasma factors influencing their
or improved clinical condition (with 59.3% of patients in improve- movement in patients with chronic
ment). Likewise, there was a statistically significant improvement schizophrenia
in BPRS, SAPS, SANS. Only 6 patients (89.3% survival) discontin- K. Rudkowski1* , J. Samochowiec1 , M. Ratajczak2 , J.
ued the treatment. No statistically significant differences between Kucharska-Mazur1 , B. Dołegowska
˛ 3 , J. Pełka-Wysiecka1 , M. Mak1 ,
the reasons for discontinuation. Likewise, there was no significant 4

M. Tarnowski , E. Tyburski 5
increase in the rate of emergence of akathisia or another extrapyra- 1 Pomeranian Medical University, Department of Psychiatry,
midal symptoms. Szczecin, Poland; 2 University of Louisville, Stem Cell Biology Program
Conclusions.– The use of A-LAI treatment in patients stabilized at the James Graham Brown Cancer Center, Louisville, USA; 3
with schizophrenia may improve adherence to treatment but also Pomeranian Medical University, Department of Microbiology,
suggests potential improvements in terms of clinical efficacy and Szczecin, Poland; 4 Pomeranian Medical University, Department of
perception of quality of life with a high profile of tolerability and Physiology, Szczecin, Poland; 5 University of Szczecin, Department of
clinical safety (2). Clinical Psychology, Szczecin, Poland
interest statement.
Background and aims.– In recent years, growing attention has been
devoted to the search for biological markers of psychotic disor-
ders. There are findings confirming the role of stem cells and factors
affecting their mobilization in first episode psychosis.
The aim of this study was to evaluate the effects of stem cell after a short period of stabilization might be caused by insufficient
mobilization and factors affecting it on cognitive performance and community care of the patients.
functioning of patients with chronic schizophrenia. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– The study included 60 patients aged 30-50, diagnosed interest statement.
with chronic schizophrenia (duration over 10 years), divided
into two subgroups: deficit schizophrenia (30) and non-deficit
schizophrenia (30), and 60 healthy controls without any psychiatric E-PP1111
or neurological disorders, matched for sex, age and level of educa- Systematic review of the prevalence of
tion. Symptom severity was assessed with the PANSS and MINI. suicidal ideation and suicidal
Cognitive performance was assessed with the MATRICS Consensus
behaviour in delusional disorder
Cognitive Battery. Patients had their blood drawn for laboratory
A. Guardia Delgado1* , A. González Rodríguez2 , A. Álvarez3 , M.
tests (SDF-1, S1P, component cascade, VSEL and HSC).
Betriu3 , F. Estrada3 , I. Parra4 , J.A. Monreal4 , D.J. Palao4 , J. Labad4
Results.– Compared to the control group schizophrenia patients 1 Corporació Sanitària Parc Tauli, Mental Health, Sabadell, Spain; 2
achieved scored lower in cognitive function tests. Correlation of the
Corporació Sanitària Parc Taulí- I3PT- CIBERSAM, Mental Health,
cognitive perfomance results with blood laboratory tests will shed
Sabadell, Spain; 3 Corporació Sanitària Parc Taulí, Mental Health,
some light on how blood stem cells and changes in the concentra-
Sabadell, Spain; 4 Corporació Sanitària Parc Taulí- I3PT- CIBERSAM-
tion of plasma factors influencing their movement may be involved
UAB, Mental Health, Sabadell, Spain
in etiopathogenesis of schizophrenia by affecting neurogenesis. * Corresponding author.
Conclusions.– These findings may help to explore the role of stem
cells and factors affecting their mobilization in chronic schizophre- Background and aims.– Suicide is a public health problem leading to
nia. a premature death worldwide. Mental illness has been associated
with an increased risk of suicide, and previous history of suicide
attempts has been identified as a robust risk factor in psychotic
disorders. Few studies have paid close attention on delusional dis-
E-Poster Presentation: Schizophrenia and other order.
psychotic disorders - Part V Our goal was to examine the prevalence of suicidal ideation and
behaviour in delusional disorder.
Methods.– A systematic electronic search was performed using
Disclosure of interest.– The authors have not supplied a conflict of PubMed, Scopus and PsycINFO databases (from 1980 to September
interest statement. 2018), according to the Preferred Reporting Items for Systematic
Reviews and Meta-analyses (PRISMA) statement. The following
search terms were used: (suicidal ideation OR suicidal behavior
E-PP1110 OR suicide) AND (prevalence OR incidence) AND (delusional disor-
The prevalence, course and stability of der). Hierarchical inclusion criteria: delusional disorder (ICD, DSM),
negative symptoms in first episode studies in English, German, French or Spanish. Case reports were
excluded.
schizophrenia. A prospective 12–15 Results.– A total of 157 articles were initially identified. After
year follow-up study the screening and selection processes, 10 studies were included:
K. Górna1* , K. Jaracz2 , K. Gołebiewska
˛ 1 , B. Grabowska-Fudala2 , J.
cross-sectional (n = 5), prospective (n = 3), retrospective (n = 1)
Kiejda1 , J. Jaracz3 and nationwide-register study (n = 1). Out of these 10 studies, 3
1 University of Medical Sciences, Department of Psychiatric Nursing,
reported the frequency of suicidal ideation (Range: 1.98–47.31%)
Poznań, Poland; 2 University of Medical Sciences, Department of and 8 of suicidal behaviour (Range: 0–29.63%). Four studies com-
Neurological Nursing, Poznań, Poland; 3 University of Medical pared rates between patients with schizophrenia and delusional
Sciences, Department of Adult Psychiatry, Poznań, Poland disorder. Higher frequency of suicidal ideation was found in delu-
sional disorder than schizophrenia (47.31% vs. 20.8%; n = 1) but
similar rates of suicide attempts (Range: 0–29.63% vs. 10–35%;
Background and aims.– During last decades several studies on neg-
n = 3).
ative symptoms (NS) have been performed in first episode of
Conclusions.– Despite the higher frequency of suicidal ideation in
schizophrenia (FES). However, long-term prospective investiga-
delusional disorder, rates of suicidal behaviour may be similar
tions are rare.
to schizophrenia. The suicide phenomenon among this condition
Aims.– To determine the prevalence, severity and stability of NS in
remains still understudied.
FES over the period of 12–15 years.
Methods.– This is a prospective study of a cohort of patients, hos-
interest statement.
pitalised for the first time between 1998 and 2002. Patients were
assessed one month after their hospitalisation (Time 1), and then
subsequently 1 year later (Time 2), 4–6 (Time 3), 7–11 (Time 4) and
E-PP1112
12 - 15 years after Time 1 (Time 5). Fifty six patients completed all of
the follow-up assessments. Psychopathological status and NS were Psychopatology in first episode
assessed with PANSS and the PANSS - Marder Negative Symptoms psychosis: a comparative study
Factor Score (NSFS), respectively. R. Guedes1* , C. Peixoto Sousa1 , E. Pereira1 , M. Mota-Oliveira2 , M.J.
Results.– Negative symptoms were found in 44.6% at time 1, and Peixoto1 , R. Curral1 , R. Coelho3 , C. Silveira1
1 Centro Hospitalar Universitário São João, Serviço de Psiquiatria-
in 51.8%, 62.5%, 62.5% and 58.9% at time 2, time 3, time 4 and
time 5, respectively. The mean NSFS differed between time points Clínica de Psiquiatria e Saúde Mental, Porto, Portugal; 2 Centro
(P = 0.009). There was an increase of symptoms’ severity between Hospitalar Universitário do Algarve, Departamento de Psiquiatria e
time 2 and 3 (P = 0.005). At the individual patient level, the stability Saúde Mental, Faro, Portugal; 3 Centro Hospitalar Universitário São
of symptoms ranged between 33.9%–58%. The symptoms present João, Clínica de Psiquiatria e Saúde Mental, Porto, Portugal
at all 5 assessments were found in 26.8% of the patients.
Conclusions.– Our study confirmed that the rate of NS is high, both
Background and aims.– The term psychosis in the first psychotic
at the early and the mid-term period after FES. The increase of NS
episode (FEP) is purely descriptive, making no assumption to eti-
ology or prognosis. FEP is psychopatologically heterogeneous and general, the six different health professions coincide in most of the
entails great diagnostic uncertainty. ICF categories reported as relevant for functioning in schizophrenia.
Psychopathological characterization and comparison between Disclosure of interest.– The authors have not supplied a conflict of
diagnostic groups of patients after FEP. interest statement.
Methods.– Retrospective observational study with FEP patients
admitted to the inpatient unit of the Psychiatry and Mental Health
Clinic, São João Hospital Center, Oporto, Portugal between 2007 E-PP1114
and 2017. Diagnosis was based on ICD-10 criteria (WHO, 1992). Relationship between self-reporting
Sociodemographic variables and psychopathological symptoms memory impairment and brain
were extracted from individual clinical processes. Psychotic symp-
volume in Korean first onset psychosis
toms were compared between three groups of patients: Group
J.Y. Kim1 , S.W. Hahn2* , Y.C. Chung3 , S.H. Lee4
1 - Schizophrenia, Schizotypal Disorder, Schizoaffective Disorder 1 Inje University, Clinical Emotion and Cognition Research
and Non-Organic Non-Specific Psychosis; Group 2 - Mental and
Laboratory, Goyang, Republic of Korea; 2 Soonchunhyang University
behavioral disorders due to the use of cannabinoids, cocaine and
Seoul Hospital, Psychiatry, Seoul, Republic of Korea; 3 Chonbuk
multiple drugs; Group 3 – Bipolar Disorder, Severe Depressive
National University Medical School, Psychiatry, Jeonju, Republic of
Episode with Psychotic Symptoms, Persistent Delusional Disorder
Korea; 4 Inje University Ilsan Paik Hospital, Psychiatry, Goyang,
and Acute Transient Psychotic Disorder.
Republic of Korea
Results.– The study included 192 patients, 144 males with a mean * Corresponding author.
age of 26.4 years. Kurt Schneider’s first-order symptoms and nega-
tive symptoms were more prevalent on Group 1 and the difference Background and aims.– The decrease of brain volume and cognitive
between the 3 groups was statistically significant. Significant differ- dysfunction including memory have been known as major char-
ences between the three groups were also found in some affective acteristics of patient with schizophrenia and first onset psychosis.
and prodromal psychotic symptoms. Few studies examined the interaction between brain volume and
Conclusions.– A careful and extensive psychopathological charac- memory in first onset psychosis. In the present study, we inves-
terization of FEP patients is essential. Such approach could have an tigated the interaction between the brain volume and subjective
important impact on the treatment, prognosis and quality of life of memory impairment of first onset psychosis.
patients, especially in patients with severe mental illnesses. Methods.– Patients with first onset psychosis (n = 34) and healthy
Disclosure of interest.– The authors have not supplied a conflict of controls (n = 34) completed measures of structural magnetic res-
interest statement. onance imaging, clinical assessments, and self-reported memory
failures (Prospective and Retrospective Memory Questionnaire:
PRMQ). A multivariate analysis of covariance, correlation, and mod-
E-PP1113 erated regression analyses were performed.
Functioning in schizophrenia: Results.– In the first onset psychosis group, volume of ventricle,
comparison between six health amygdala, hippocampus, superior temporal gyrus (STG), and others
professions were significantly lower and PRMQ score was higher than healthy
G. Guilera1* , M. Barrios1 , E. Rojo2 , J. Gómez-Benito1 , L. Nuño3 control group. There was a significant group dependent moderation
1 University of Barcelona, Institute of Neurosciences - UBNeuro, effect between the PRMQ score and the right STG (rSTG) volume.
Barcelona, Spain; 2 Benito Menni, Complex Assistencial en Salut In first onset psychosis group, the PRMQ score negatively predict
Mental, Sant Boi de Llobregat, Spain; 3 Hospital Clínic de Barcelona, rSTG volume, while in healthy control group, this prediction was
Clinic Institute of Neurosciences, Barcelona, Spain positive.
* Corresponding author. Conclusions.– Our results indicate that the awareness of memory
impairment of themselves could impact on rSTG volume with oppo-
Background and aims.– The International Classification of Func- site direction between first onset psychosis and healthy controls.
tioning, Disability and Health (ICF) offers a framework for In first onset psychosis, the awareness of memory impairment
describing functioning and disability in any health condition such could induce the increase of rSTG brain volume. However, healthy
as schizophrenia. This study aims a) to identify the most common controls showed decreased rSTG volume when they aware their
problems of patients with schizophrenia from the experts’ perspec- memory impairment.
tive using the ICF, and b) to compare health professions in terms Disclosure of interest.– The authors have not supplied a conflict of
of ICF categories reported as relevant for describing functioning in interest statement.
schizophrenia.
Methods.– Six 3-round worldwide electronic-mail surveys, based
on a consensus-building Delphi method, were independently E-PP1115
conducted with psychiatrists, psychologists, nurses, occupational Impact of biological and psychological
therapists, social workers and physiotherapists experienced in factors on the social functioning in
the treatment of individuals with schizophrenia. Experts were
schizophrenia and bipolar disorder
asked about the problems they commonly treat in patients with
schizophrenia. Participation was able in five languages: Chinese, patients
English, French, Russian and Spanish. Experts’ responses were Y. Kim1 , A. Kwon1 , D. Min1 , M.J. Jin1 , S.W. Hahn2* , S.H. Lee3
1 Inje University, Clinical Emotion and Cognition Research
linked to the ICF system using stablished linking rules.
Results.– A total of 790 experts representing all six World Health Laboratory, Goyang, Republic of Korea; 2 Soonchunhyang University
Organization regions participated in the Delphi study, of whom Seoul Hospital, Psychiatry, Seoul, Republic of Korea; 3 Inje University
638 finished the third round. Health professionals identified a wide Ilsan Paik Hospital, Psychiatry, Goyang, Republic of Korea
range of problems in functioning of persons with schizophrenia,
specifically related to Body functions (e.g., attention), Activities and Background and aims.– Even though previous studies have investi-
participation (e.g., interpersonal interactions), and Environmental gated social functioning in schizophrenia and bipolar patients, only
factors (e.g., family support). a few studies have explored the impact of both psychological and
Conclusions.– This study has identified the most common problems biological factors on social functioning simultaneously. This study
of patients with schizophrenia from the experts’ perspective. In aimed to examine which factors significantly predict the social
functioning in patients with schizophrenia, bipolar disorder, and antipsychotic treatment quickly and supporting many patients to
healthy controls. later stop medication. Cardiometabolic monitoring is taking place
Methods.– Twenty seven patients with schizophrenia and 30 with but requires improvement to be comprehensive and timely.
bipolar disorder as well as twenty five healthy controls com- Disclosure of interest.– The authors have not supplied a conflict of
pleted measures of social functioning (Questionnaire of social interest statement.
functioning), neurocognition (verbal fluency), social cognition
(basic empathy scale), and childhood trauma questionnaire (CTQ).
For biological measurements, mismatch negativity (MMN) of the E-PP1117
event-related potential and heart rate variability (HRV) were Organic psychosis: CADASIL
recorded for all participants. Pearson’s correlation analysis and syndrome. A clinical report
multiple hierarchical regression were performed to explore the E. Hernández Padrón* , E. Vera Barrios, L. Povedano García, L.
impacts of these measures on the social functioning. Navarro Morejón, R. Calles Marbán, A. Sánchez Pavesi, F.J. García
Results.– Childhood trauma was a significant predictor of social Gómez-Pamo, M.D.R. Cejas Méndez
functioning in patients with schizophrenia (ˇ = −.488, p = .016), Hospital Universitario de Canarias, Psychiatry, Santa Cruz de
while HRV significantly predicted social functioning in patients Tenerife, Spain
with bipolar disorder (ˇ = .486, p = .015). Also, empathy and * Corresponding author.
MMN significantly predicted social functioning in healthy controls
(ˇ = .350, p = .046, ˇ = −.528, p = .009, separately). Background and aims.– Differential diagnosis is needed when
Conclusions.– Our results suggest that the social functioning of there are acute psychiatric symptoms. At this point, we find it
schizophrenia, bipolar disorder, and healthy controls could be influ- helpful to report the Cerebral Autosomal Dominant Arteriopathy
enced by different biological and psychological factors. Specifically, with Subcortical Infarcts and Leukoencephalopathy, also known as
early traumatic experiences and reduced HRV could negatively CADASIL, a genetic disease (NOTCH3 gene), characterized by sub-
affect the social functioning of schizophrenia and bipolar patients, cortical ischemic events, epilepsy, migraine, cognitive deficits and
respectively. In addition, the effects of empathy and MMN on social mood disturbance. The detection of this disease through molecular
functioning should be emphasized for healthy controls. genetic tests is important since angiography and thrombolytic ther-
Disclosure of interest.– The authors have not supplied a conflict of apy is contraindicated because of the increased risk for ischemic
interest statement. events, so a preventive treatment is needed, as well as a further
investigation for specific treatments including gene therapy.
Methods.– We report the case of a 22-year-old woman, who was
E-PP1116 hospitalized for the third time due to acute psychotic symptoms,
Analysis of the current antipsychotic related to a conflictive familiar situation without history of sub-
prescribing and monitoring practice stance abuse. When the battery of tests for her evaluation was
ordered, a magnetic resonance imaging was included because of
in a service for early intervention in
the intense headaches she had. The brain imaging showed subcorti-
psychosis in South West England: a cal demyelinating and ischemic lesions in the temporal and frontal
service evaluation study poles.
A. Hayes1* , A. Hodgkins2 , F. Burbach2 , R. Iosub1 Results.– The symptoms accompanying the results of the neu-
1 Somerset Partnership NHS Foundation Trust, Psychiatry, Taunton, roimaging, such as migraine and delusional ideation related to
United Kingdom; 2 Somerset Partnership NHS Foundation Trust, mood disturbance due to acute stress, suggested CADASIL syn-
Somerset Team for Early Psychosis, Taunton, United Kingdom drome, so we decided to include a genetic test focusing this case as
a organic psychosis.
Conclusions.– The possibility of an organic psychosis even at a young
Background and aims.– Early intervention is recommended for first age shouldn’t be ignored. Organic psychosis is not easy to diag-
episode psychosis, and time from onset of symptoms to provision nose, so sometimes complementary tests, including neurologic and
of treatment has a significant effect on long-term outcomes. Ser- genetic tests, should be considered during the patient evaluation
vices focussing on this early intervention have been set up across process.
the UK. In this study, we investigated the use of antipsychotics for Disclosure of interest.– The authors have not supplied a conflict of
people using an Early Intervention service in Somerset, South West interest statement.
England.
Methods.– We reviewed case notes of all those on the Early Inter-
vention caseload in June and July 2018 and noted the prescribing E-PP1118
patterns for antipsychotics, including types, timings, and subse-
Improving physical health for those
quent monitoring.
Results.– Of 128 people on the EI caseload, 59% were currently with severe mental illness
taking antipsychotics, and 87% had taken them at some point dur- P. Hjorth1* , C.B. Kristiansen2 , A. Juel3
1 University of Southern Denmark, Department of Regional Health
ing the intervention. Within 14 days of intervention, 79% received
antipsychotic treatment. Medications taken for the longest times Research. Psychiatric Hospital- Vejle., Vejle, Denmark; 2 University of
and therefore likely to have been the most effective and/or best tol- Southern Denmark, Department of Psychiatry-University function.,
erated included Olanzapine (37%), Aripiprazole (23%), Risperidone Odense, Denmark; 3 Region Zealand, Psychiatry, Slagelse, Denmark
(17%), Quetiapine (12%), Amisulpride 6 (5%), with 7% prescribed
typical antipsychotics. Inpatient psychiatrists were more likely to Background and aims.–
prescribe typical antipsychotics, and prescribed a greater num- Background.– In the past decades there has been focus on physical
ber of medications than community psychiatrists. Over two thirds health in people with mental illness. A common cause of prema-
(69%) of patients were accepted to the intervention whilst in the ture death in people with schizophrenia is cardiovascular diseases.
community rather than on inpatient wards. Cardiometabolic mon- Additionally, people with severe mental illness have a much shorter
itoring was in progress for 67% of relevant patients and fully life expectancy than the general population. Overweight and obe-
complete in only 36%. sity is a health problem leading to a higher risk of developing
Conclusions.– This study indicates that services focussing on Early physical-co-morbidities, such as Type 2 diabetes, cardiovascular
Intervention in first-episode psychosis are effective at providing diseases and cancer. Furthermore, obese people may experience
a poorer quality of life with stigmatization and studies have shown Disclosure of interest.– The authors have not supplied a conflict of
that they are less prone to remain on treatment with psychotropics. interest statement.
Aim.– We aimed at reducing cardiovascular risk factors through a
2.5 years program in our clinical practice in non-selected patients
with schizophrenia. Furthermore, we examined which character- E-PP1120
istics were associated with a positive outcome. Cognitive rehabilitation and training
Methods.– Our program used methods already proven effective in with exercise for schizophrenia
short-terms trials. The intervention was evolved from studies using
(cortex-SP): psychopathological and
active awareness, motivational interviewing, group sessions and
staff role modeling. The intervention was aimed to be practical as physical preliminary baseline
a continuous part of treatment and care. outcomes
Results.– There were improvement in some of the variable we tested M. Tous-Espelosin1 , N. Iriarte2* , S. Maldonado-Martín1 , I.
and these variables can be a proxy indicator for cardiovascular risk. Hervella2 , A. Sampedro3 , A. MartinezAguirre-Betolaza1 , P. Corres1 ,
The program was evaluated as suitable for implementation in daily C. Pavón2 , G. García2 , E. Elizagarate2 , J. Peña3 , N. Ojeda3 , N.
practice. Ibarretxe-Bilbao3 , A. Ortiz de Zárate2 , J.A. García Marchena2 , P.
Conclusions.– We considered the program to be succesfull. Sánchez2
1 Faculty of Education and Sport-Physical Activity and Sport Sciences
interest statement. Section. University of the Basque Country UPV/EHU, Department of
Physical Education and Sport, Vitoria- Gasteiz, Spain; 2 Osakidetza,
Mental Health Service, Vitoria- Gasteiz, Spain; 3 University of Deusto,
E-PP1119 Department of Methods and Experimental Psychology, Bilbao, Spain
Abnormal causal connectivity of left
superior temporal gyrus in drug-naïve Background and aims.– Currently available antipsychotic agents are
first-episode adolescent-onset effective drugs for the treatment of positive symptoms and the pre-
schizophrenia: a resting-state FMRI vention of relapses. Nevertheless, there is a lack of effective drugs
study for the treatment of negative symptoms and cognitive impairment
H. Lyu1 , X. Wang2 , B. Sun3 , Z. Zhao4 , D. Shang5 , F. Pan1 , Y. Xu1 , D. in schizophrenia (SP). Both domains of symptoms are the best pre-
Xu6 , M. Huang1* dictors of functional status and quality of life of patients with SP. In
1 The First Affiliated Hospital- Zhejiang University School of Medicine, addition, physical health care plays a major role in the management
Department of Psychiatry, Hangzhou, China; 2 Zhejiang University, of SP due to the high cardiovascular risk and mortality associated
School of Medicine, Hangzhou, China; 3 Ningbo Mental Hospital, with this disorder. The main purpose was to determine some key
Psychiatry, Ningbo, China; 4 East China Normal University, Shanghai physical, physiological and psychopathological markers of health
Key Laboratory of Magnetic Resonance, Shanghai, China; 5 The First status in adults with SP.
Affiliated Hospital- Zhejiang University School of Medicine, Methods.– In this experimental study, 41 patients (42.5 ± 9.2 year
Department of Radiology, Hangzhou, China; 6 Columbia University, old, 24% women) with SP were assigned to cognitive remediation
New York State Psychiatric Institute, New York, USA (REHACOP program) and exercise training (combination of low vol-
* Corresponding author. ume high intensity aerobic interval training and resistance training)
for a 20-week period. Both groups participated in these training
Background and aims.– Functional brain abnormalities have been sessions 3 days/week, 1 h/day.
studied in AOS cases. However, the alterations of causal connectiv- Results.– The studied population showed overweight (27.9 ± 5.1),
ity between brain regions in AOS remains unclear. normotensive blood pressure values (120/69 mmHg), poor car-
Methods.– Thirty-two first-episode drug-naïve AOS patients and diorespiratory fitness (24.9 ± 8.3 mL·kg-1·min-1) and rest heart
27 healthy controls (HC) were recruited for resting-state func- rate (80.2 ± 12.0 bpm) values, and 59% of patients were smokers
tional MRI scanning. The brain region with the between-group (20 cigarettes/day). According to psychopathological parameters
difference in Regional homogeneity (ReHo) values was chosen as a the average age of disease onset was 24 years old, moderately ill
seed to perform the Granger causality analysis (GCA) and further (measured with the clinical Global Impression Severity scale) and
detect the alterations of causal connectivity in AOS. Both receiver- seven admission in hospital, and high severity of negative symp-
operating characteristic analysis and probabilistic neural network toms scales (PANNS, CAINS and BNSS).
were applied to test the possibility of using abnormal brain con- Conclusions.– Psychopathological outcomes (both positive and neg-
nectivity for distinguishing cases from controls. ative symptoms), cardiovascular fitness and physical parameters
Results.– AOS patients exhibited increased ReHo values in left (only in exercise group) are aimed to improve in patients with SP.
superior temporal gyrus (STG) compared with HC. Significantly Disclosure of interest.– The authors have not supplied a conflict of
decreased values of outgoing Granger causality from left STG to interest statement.
right superior frontal gyrus and right angular gyrus were observed
in GC mapping for AOS. Significantly stronger causal outflow from
left STG to right insula and stronger causal inflow from right E-PP1121
middle occipital gyrus (MOG) to left STG were also observed in Cognitive remediation and training
AOS patients.(Table 1, Figure 1) Based on assessments of the two with exercise for schizophrenia:
strengthened causal connectivity of the left STG with insula and
cortex-sp study, a clinical trial
MOG, a cross-validated probabilistic neural network model could
N. Iriarte1* , M. Tous-Espelosin2 , I. Hervella1 , A. Sampedro3 , S.
discriminate all patients from controls with remarkable accuracy
Maldonado-Martín2 , C. Pavón1 , A. MartinezAguirre-Betolaza2 , G.
at 94.9%. (Figure 2)
García1 , P. Corres2 , E. Elizagarate1 , N. Ojeda3 , J.A.
Conclusions.– Patients with drug-naïve first-episode AOS exhibit
García-Marchena1 , A. Ortiz de Zárate1 , J. Peña3 , N.
brain functional connectivity abnormalities in left STG. The alter-
Ibarretxe-Bilbao3 , P. Sánchez1
ations of directional connections in left STG may play an important 1 Osakidetza, Mental Health Service, Vitoria-Gasteiz, Spain; 2 Faculty
role in the pathogenesis of AOS and serve as potential biomarkers
of Education and Sport-Physical Activity and Sport Sciences Section.
for the disease.
University of the Basque Country UPV/EHU, Department of Physical
Education and Sport, Vitoria-Gasteiz, Spain; 3 University of Deusto, Conclusions.– Our survey revealed to a large extent guideline-
Department of Methods and Experimental Psychology, Bilbao, Spain concordant prescribing patterns for patients with schizophrenia.
* Corresponding author. A resurgence of interest in LAIs prescribing at discharge was noted.
The almost ultimate use of oral SGAs compared to LAI FGAs has its
Background and aims.– Cognitive deficits and negative symptoms in probable explanation in the prior-authorization policies related to
patients with schizophrenia (SP) are the most relevant factor in pre- the prescription of LAI SGAs in our country.
dicting functional outcome. Antipsychotics, however, have shown Disclosure of interest.– The authors have not supplied a conflict of
a lack of ability in addressing these symptoms. Cognitive remedia- interest statement.
tion (CR) and exercise training (ET), separately, have demonstrated
encouraging results of efficacy in improving these deficits. The main
goals of the present clinical trial, are: (1) to determine brain related- E-PP1123
structural and functional changes associated with CR and ET, and Health related quality of life and
(2) to analyze the effectiveness of the two treatments on physical,
social functioning in patients with
psychological, cognitive and functional parameters.
Methods.– Patients with SP (n = 150) will be randomized into an negative symptoms: a 12–15 year
active control group (occupational activities) or one of the two multi-follow-up study after
experimental groups (3 days/week): treatment with REHACOP first-episode schizophrenia
program (in Spanish, COgnitive REHAbilitacion in patients with K. Jaracz1* , K. Górna2 , B. Grabowska-Fudala1 , K. Gołebiewska
˛ 2 , J.
Psychosis), or ET combining low volume high intensity aerobic 2

Kiejda , J. Jaracz 3
interval training and resistance training, during five months. 1 Poznan University of Medical Sciences, Department of Neurological
Results.– Physical (body composition), physiological (cardiorespira- Nursing, Poznań, Poland; 2 Poznan University of Medical Sciences,
tory fitness and blood pressure), clinical, cognitive and biochemical Department of Psychiatric Nursing, Poznań, Poland; 3 Poznan
parameters (including the brain-derived neurotrophic factor), as well University of Medical Sciences, Department of Adult Psychiatry,
as images by nuclear magnetic resonance will be measured and Poznań, Poland
performed before and after the intervention. * Corresponding author.
Conclusions.– This challenging study expects to support current evi-

dence of efficacy of both CR and ET interventions and will help to Background and aims.– Negative symptoms (NS) may have an
better understand the potential of non-pharmacological treatment unfavourable effect on a long-term prognosis in first-episode
for improving the functional outcome of people with SP. schizophrenia (FES). However, long-term observations of FES
Disclosure of interest.– The authors have not supplied a conflict of patients are fairly rare.
interest statement. This study aimed to determine quality of life (QoL) and social func-
tioning of the FES patients over a fifteen year follow-up period and
to compare QoL and social functioning in patients with and without
E-PP1122 NS.
Psychotropic drug prescribing Methods.– The sample consisted of 56 FES patients who were
assessed one month after their first psychiatric hospitalisation
patterns for schizophrenic patients at
(Time1), and then subsequently 1 (Time 2), 4–6 (Time 3), 7–11
the time of hospital discharge from (Time 4) and 12–15 (Time 5) years later. Negative symptoms were
acute inpatient setting: a five year assessed with the PANSS - Marder Negative Symptoms Factor Score
comparison (NSFS), QoL and social functioning with WHOQoL and Birchwood
D. Ivanov1* , K. Todorova-Nenova2 Social Functioning Scale, respectively.
1 Medical University, Varna, Faculty of Medicine, Varna, Bulgaria; 2 Results.– At all measurement points of the study patients with
Medical University, Varna, Department of Psychiatry and Medical NS showed significantly worse social functioning and subjective
Psychology, Varna, Bulgaria QoL than those without NS (P < 0.001). In the group of patients
* Corresponding author. with NS, the SFS and WHOQoL scores did not change significantly
between Time 1 and Time 5 (P = 0.913) and (P = 0.586), respectively.
Background and aims.– Despite existing guidelines for schizophre- In the group without NS the WHOQoL score also did not change
nia treatment, prescription patterns are affected by different (P = 0.963). However, there was a significant effect for time in the
factors. The objective of this study is to investigate psychotropic SFS score which was higher at Time 4 (P = 0.036).
prescribing at time of discharge from an acute psychiatric inpa- Conclusions.– The study confirms an unfavourable long-term
tient unit of a university-affiliated hospital in Bulgaria and outline impact of NS on real-life functioning of FES patients. An absence
the changes over a five-year period (2011 – 2016). of negatives symptoms increases chances for recovery.
Methods.– A total of 337 discharge summaries (164 in 2011 and Disclosure of interest.– The authors have not supplied a conflict of
173 in 2016) for all patients diagnosed with schizophrenia (ICD-10 interest statement.
criteria) were retrospectively reviewed.
Results.– In 2016, similar to 2011, the majority of patients diagnosed
with schizophrenia were discharged on antipsychotic monother- E-PP1124
apy with a second-generation antipsychotic (SGA), respectively Levels of plasma uric acid in
111 and 113. Nonetheless, more patients were discharged on
schizophrenia
two antipsychotics in 2016 (p < 0.01) with the number of patients
K. Jmal1,2* , M. Naifar1,2 , M. Maalej3 , W. Guidara2 , A.S. Ellouze3 , S.
receiving long-acting injectables (LAIs) being notably higher
Omri3 , M. Maâlej3 , N. Charfi3 , J. Ben Thabet3 , F. Ayadi1,2
(p < 0.01). A LAI first-generation antipsychotic (FGI), zuclopenthixol 1 Habib Bourguiba University Hospital, Laboratory of Biochemistry,
decanoate, was the upmost-prescribed antipsychotic in our 2016
Sfax, Tunisia; 2 Faculty of Medicine of Sfax, UR :12ES17 « Molecular
data, compared to clozapine in 2011. Out of all patients prescribed
bases of human pathology », Sfax, Tunisia; 3 Hedi Chaker University
LAIs in 2016, only 8(13.3%) received a LAI SGA. Risperidone was
Hospital, Psychiatry “C” Department, Sfax, Tunisia
the most prescribed oral antipsychotic in 2016, closely followed by * Corresponding author.
clozapine. An upward trend in the prescription of benzodiazepines
and anticholinergics in 2016 was observed (p < 0.01), presumably Background and aims.– Schizophrenia is a disorder that causes a
coinciding with the increasing use of LAI FGAs. high risk of premature death, a high occurrence of positive and neg-
ative symptoms and disorganized thoughts and behavior rendering CRP in the schizophrenia group were significantly increased com-
a normal life in society difficult. pared to controls (6,58 ± 17 mg/L VS 1,79 ± 1,87 mg/L; p < 0,01).
There is evidence of dysregulation of the antioxidant defense sys- In antipsychotic-free patients, CRP level was positively correlated
tem in schizophrenia. with the severity of the psychopathology as measured by PANSS.
The purpose of the present study was to examine whether uric This relationship was especially notable for positive (r = 0.19,
acid, a potent antioxidant, is reduced in the plasma of patients with p = 0.007), but not negative symptoms (r = 0,07; p = 0,29).
schizophrenia. Conclusions.– The elevation of CRP level is seen in drug-free chronic
Methods.– This was a cross-sectional case-control study con- schizophrenia. However, studies with a larger sample size are
ducted between June 2016 and July 2018 on antipsychotic-free required to confirm these results.
schizophrenia patients compared to healthy controls. Patients Disclosure of interest.– The authors have not supplied a conflict of
were hospitalized at the psychiatric C department in Hedi-Chaker interest statement.
University-Hospital of Sfax. The diagnosis of schizophrenia was
established according to DSM-5 criteria. The symptoms’ severity
was evaluated according to the positive and negative syndrome E-PP1126
scale. Cognitive functions were evaluated according to the Montreal The dietary pattern of patients with
Cognitive Assessment scale. schizophrenia: preliminary results
The analysis of uric acid levels was performed using a colorimetric J. Jović1* , D. Ignjatović-Ristić2,3 , M. Jovčić3 , I. Ristić4
®
method by Cobas 6000 (Roche ) 1 University of Prishtina – Kosovska Mitrovica, Faculty of Medicine,
Results.– This study included 45 patients and 100 healthy controls. Kosovska Mitrovica, Serbia; 2 Clinical Center Kragujevac, Psychiatric
The blood uric acid level was significantly lower in schizophre- Clinic, Kragujevac, Serbia; 3 University of Kragujevac, Faculty of
nia patients compared to controls. (286,07 ± 68,9 mmol/l vs Medical Sciences, Kragujevac, Serbia; 4 University of Belgrade,
315,8 ± 65,6 mmol/l; p = 0,02). There was a significant and nega- Faculty of Medicine, Belgrade, Serbia
tive correlation between uric acid levels and the severity of either * Corresponding author.
negative and positive symptoms.
Positive and significant correlations were found between uric acid Background and aims.– Patients suffering from schizophrenia have
levels and body mass index. reduced life expectancy compared to the general population, pri-
Conclusions.– The present findings showed that plasma uric acid marily because of earlier occurrence of cardiovascular disease.
levels were significantly lower in schizophrenic patients than in This condition can be explained through high rates of metabolic
normal control subjects, providing further support to the hypoth- syndrome in these patients, with several risk factors for cardio-
esis that there exist in schizophrenia defects of the antioxidant vascular disease - abdominal obesity, atherogenic dyslipidemia,
system. hypertension, and impaired insulin and glucose metabolism. Sev-
Disclosure of interest.– The authors have not supplied a conflict of eral epidemiological studies have suggested a cardio-protective
interest statement. role of the Mediterranean Diet. The aim was to investigate the
quality of food habits in the population of patients diagnosed with
schizophrenia.
E-PP1125 Methods.– Ninety-five patients diagnosed with schizophrenia
Inflammatory status in antipsychotic (51 male, mean age 46.11 ± 11.61) were included. A Short
Mediterranean-diet questionnaire was used.
free schizophrenic patients
Results.– 61.1% of the subjects were tobacco smokers. Only 12.6% of
K. Jmal1,2* , M. Naifar1,2 , M. Maalej3 , W. Guidara2 , A.S. Ellouze3 , I.
subjects used olive oil in their diet, 67.4% had one meal with vegeta-
Hchicha1 , S. Omri3 , M. Maalej3 , N. Charfi3 , F. Ayadi1,2 , J. Ben
bles, and 80% one meal with fruit daily. 58.9% did not drink soda,
Thabet3
1 Habib Bourguiba University Hospital, Laboratory of Biochemistry, while almost no subjects (2.1%) drank wine. Only 5.4% ate more
than 3 meals with legumes per week. 40% of the participants did
Sfax, Tunisia; 2 Faculty of Medicine of Sfax, UR :12ES17 « Molecular
not eat any fish at all, while 46.4% ate fish only once per week. There
bases of human pathology », Sfax, Tunisia; 3 Hedi Chaker University
were no statistically significant differences between the genders in
Hospital, Psychiatry “C” Department, Sfax, Tunisia
* Corresponding author. eating habits.
Conclusions.– Our results found that people suffering from
Background and aims.– Schizophrenia is associated with the acti- schizophrenia had bad dietary habits, which is in line with the find-
vation of the immune/inflammatory system. C-reactive protein is ings of prior research. It could be plausible that these dietary habits
an inflammatory marker of hepatic origin linked to metabolic and may be a cause of higher incidence of metabolic abnormalities
cardiovascular diseases and mortality in the general population. It Disclosure of interest.– The authors have not supplied a conflict of
may be associated with schizophrenia. interest statement.
The purpose of the present study was to examine whether CRP is
elevated in the plasma of patients with schizophrenia.
Methods.– This was a cross-sectional case-control study con-
ducted between June 2016 and July 2018 on antipsychotic-free
E-Poster Presentation: Schizophrenia and other
schizophrenia patients compared to healthy controls. Patients were psychotic disorders - Part VI
hospitalized at the psychiatric C department in Hedi Chaker Uni-
versity Hospital (UH) in Sfax. The diagnosis of schizophrenia was
established according to DSM-5 criteria. The symptoms’ sever- E-PP1127
ity was evaluated by the positive and negative syndrome scale Gut permeability: a possible origin of
(PANSS). Cognitive functions were evaluated according to the Mon-
low grade inflammation and redox
treal Cognitive Assessment (MoCA) scale. The analysis of CRP levels
was performed in the laboratory of Biochemistry in Habib Bour- dysregulation in schizophrenia
guiba UH in Sfax using an immunoturbidimetric method by Cobas D. Juchnowicz1* , M. Dzikowski2 , J. Rog2 , M. Koziol3 , N.
® Waszkiewicz4 , A. Zalewska5 , M. Maciejczyk6 , I. Dzikowska7 , H.
6000 Analyser (Roche )
Karakula-Juchnowicz2
Results.– The sample consisted of 145 individuals: 45 with 1 Medical University of Lublin, Department of Psychiatric Nursing,
schizophrenia and 100 with no psychiatric disorder. The levels of
Lublin, Poland; 2 Medical University of Lublin, 1st Department of
Psychiatry- Psychotherapy and Early Intervention, Lublin, Poland; 3 Korean version of the Wechsler Adult Intelligence Scale in psychosis
Medical University of Lublin, Department of Clinical Microbiology, participants. The severity of clinical symptoms were measures
Lublin, Poland; 4 Medical University of Bialystok, Department of using the Scale for the Assessment of Negative/Positive Symptoms
Psychiatry, Bialystok, Poland; 5 Medical University of Bialystok, (SANS/SAPS).
Department of Restorative Dentistry, Bialystok, Poland; 6 Medical Results.– Compared to HCs, psychosis participants showed signifi-
University of Bialystok, Department of Physiology, Bialystok, Poland; cantly lower volumes in the left FG (p = 0.006), left POs (p = 0.027),
7 Medical University of Lublin, Department of Dermatology- and left HG (p = 0.008). A multiple linear regression model (F(5,
Venerology and Paediatric Dermatology, Lublin, Poland 61) = 10.04, p < 0.001) revealed that verbal intelligence of psychosis
* Corresponding author. participants was positively associated with the left FG (B = 0.003,
p = 0.020) and PT volumes (B = 0.010, p = 0.023). The left FG vol-
Background and aims.– Oxidative damage and inflammation are umes showed negative correlation with the SAPS subscale scores
known to be involved in the pathogenesis of schizophrenia, how- of hallucinations (r = −0.359, p = 0.021) and left PT volumes showed
ever, their origins remain obscure. We hypothesise that increased negative correlations with the SAPS subscale scores of positive for-
gut permeability, induced by environmental triggers, leads to mal thought disorder (r = −0.336, p = 0.032).
increased levels of inflammation markers and redox imbalance. Conclusions.– Structural abnormalities of the left FG and PT may
These disruptions in homeostatic mechanisms induce neurotrans- play an important role in language processing and clinical mani-
mitter imbalances and, as a result, cause psychotic symptoms. festations of psychosis.
The objective of this study was to find relationships between Disclosure of interest.– The authors have not supplied a conflict of
redox state and markers of inflammation and gut permeability in interest statement.
schizophrenia patients.
Methods.– Antioxidants (CAT, GPx, SOD-1, GR, GSH, TAC and FRAP)
and inflammatory/gut permeability markers (IL-6, hsCRP, sCD14, E-PP1129
ASCA, AGA IgG/IgA) were estimated in blood plasma in 98 patients Representations of pathological
who fulfiled DSM-5 criteria for schizophrenia. Clinical data includ-
bodily sensations in delusional
ing the duration and course of the illness were also collected.
Results.– The duration of illness was inversely related to CAT and infestation and skin picking disorder
SOD-1 levels, and positively related to GR and TAC levels. Both A. Malyutina1 , M. Vinogradova1 , S. Khrushchev1,2*
1 Lomonosov Moscow State University, Psychology Department,
the number of psychotic episodes and the number of hospital-
izations were negatively related to CAT and SOD-1 levels, and Moscow, Russia; 2 National Research Center for Hematology,
positively related to GSH and TAC levels. A negative relationship Psychiatry and Neurology Department, Moscow, Russia
between hsCRP and SOD-1 levels was found. An inverse relation-
ship between ASCA and GSH levels was observed while a positive
Background and aims.– Delusional infestation (DI) and skin
relationship between IL-6 and CAT levels was noted.
picking disorder (SPD) are primary psychiatric disorders with
Conclusions.– This study suggests that oxidative stress and inflam-
complaints of pathological bodily sensations and skin-focused
mation are associated with the pathogenesis and/or aetiology of
self-destructive behavior due to delusional beliefs or obsessive-
schizophrenia. Increased gut permeability is the proposed trigger
compulsive/impulse-control pathology. Psychological components
for redox and immune imbalances. Further research is needed to
of these disorders are discussed because of the subjective severity
determine the potential mechanism and causal link explaining this
of unpleasant bodily sensations.
phenomenon in psychiatric patients.
Objectives.– to investigate representations of pathological bodily
sensations in DI and SPD.
interest statement.
Methods.– 33 patients with DI and 30 patients with SPD par-
ticipated in the study. Patients completed The Hospital Anxiety
and Depression Scale (HADS). The psychosemantic method “Clas-
E-PP1128
sification of sensations” was used, patients were asked to select
Structural abnormalities in the left bodily sensations in general and associated with disease from
fusiform gyrus and planum temporale 80 descriptors: skin (“itch”), inner body (“sickness”), receptor
are associated with verbal intelligence (“hairy”), emotional (“anxiety”), dynamics (“exhaustion”) and atti-
and positive symptoms in patients tudinal (“badly”) descriptors. Mann-Whitney U-Test and Fisher’s
exact test were applied.
with psychosis
Results.– Scores on HADS-anxiety were significantly higher in
S.H. Lee, M.J. Bang, S. Jung* , A. lee
DI (U = 305,5; p = 0,009). Although there were no significant dif-
CHA Bundang medical center, department of psychiatry, bundang,
ferences on HADS-depression, more scores of sub-clinical and
Republic of Korea
* Corresponding author. clinical depression were in DI comparing to SPD. Among bod-
ily sensations in general patients with DI chose more frequently
Background and aims.– Language processing dysfunction in psy- (p ≤ 0,05) skin (“tickle”), receptor (“hairy”) and attitudinal (“tor-
chosis has been suggested to be associated with poor clinical turously”) descriptors. Associated with disease skin (“motion”),
outcome. However, few studies have investigated the relationships receptor (“flash”), attitudinal (“exhausting”) and emotional (“dev-
among structural abnormalities in the language processing areas astation”) descriptors were chosen more frequently (p ≤ 0,05) in
(LPAs), verbal intelligence, and clinical symptoms in psychosis. We DI that demonstrated greater importance of unpleasant bodily and
hypothesized that the volumes of the LPAs, including the pars trian- receptor sensations.
gularis, pars opercularis (POs), insula, Heschl’s gyrus (HG), planum Conclusions.– Representations of bodily sensations with corre-
temporale (PT), and fusiform gyrus (FG) would be significantly asso- spondence to intensity of anxiety/depression states differ in
ciated with verbal intelligence and clinical symptoms. psychodermatological disorders which allows to discuss its distor-
Methods.– Ninety-four patients with psychosis and 52 healthy tion in DI as an increased attention to painful sensations and an
controls (HCs) participated in this study. Structural magnetic res- attribution of external processes to bodily experience.
onance imaging (MRI) data were acquired from all participants, Disclosure of interest.– The authors have not supplied a conflict of
and the volumes of the LPAs were estimated using FreeSurfer interest statement.
software package. Verbal intelligence were assessed using the
E-PP1130 E-PP1132
The burden of people caring for Differencial diagnosis of acute
patients with schizophrenia and schizophrenia and stimulant
affective disorder drug-related psychosis
J. Kiejda1* , K. Górna1 , K. Gołebiewska
˛ 1 , K. Jaracz2 E. Klembovskaya* , S. Oskolkova, O. Pechenkina, L. Satyanova, T.
1 University of Medical Sciences, Department of Psychiatric Nursing, Mustafina
Poznan, Poland; 2 University of Medical Sciences, Department of Serbsky National Medical Research Center for Psychiatry and
Neurologic Nursing, Poznan, Poland Narcology, Endogeneous Psychosis, Moscow, Russia
Background and aims.– The process of disinstitutionalization and Background and aims.– The abuse of synthetic psychoactive sub-
reform of the psychiatric care system contributed to the escalate of stances is widespread, and closely connected with psychoses
the role and responsibility of informal caregivers in the care of men- related with drug intoxication. Synthetic cathinones is a new class
tally ill people. Long-term care, especially for more than 5 years, of designer drugs, and it is capable to provoke psychoses. Use
can cause effects in the form of subjective and objective burden for of synthetic simulants can cause phenomena of the endogenous
more than 20 hours and deterioration of the caregivers’ healthe. spectrum, and requires the differentiation of these states from
Methods.– 101 pairs of caregivers and patients with schizophrenia schizophrenia.
and 130 pairs of caregivers and patients with affective disorders Methods.– To improve the diagnosis and forensic psychiatric eval-
(in total - 231 pairs). The study used a Stages Assessment accord- uation of mental states related to the use of synthetic cathinones,
ing to Steven Zarit (ZCBI) for load measure the burden and set 32 patients who used stimulants drugs (synthetic cathinones) (14
of standarized research instruments were used to evaluate other patients with schizophrenia, who used stimulants, 18 stimulant-
characteristics of the paprticipants. drug addicts), were examined by clinical and psychologic methods
Results.– Most carers are women, on average at the age of 50, Results.– We found that mental conditions of drug addicts were
people from closest family (95%), with advantage of profession- psychotic, polymorphous and acute. The main features were fear
ally active, with secondary or higher education, devoting more and anxiety, derealization, depersonalization phenomena, para-
than 20 hours to care per week (70%). High load (ZCBI> 40 points) noid, illusions and hallucinations with elements of the syndrome
occurred in 36.2% of respondents. These people are mainly care- of mental automatism, various thought disturbances. Psychoses
givers of patients with schizophrenia (64.5%, p < 0.001). developed immediately after use of drugs, the phenomena of
Conclusions.– In view of the significant percentage of carers expe- “collective reading of thoughts” and open minds, verbal pseu-
riencing a high burden related to mentally ill care, especially for dohallucinations were unstable and short-term. Psychoses in
schizophrenia, systemic support for these people is necessary. schizophrenic patients were the combination of endogenous
Disclosure of interest.– The authors have not supplied a conflict of and exogenous disorders with predominance of verbal pseudo-
interest statement. hallucinations and delusional symptoms. The use of stimulants
reinforced endogenous psychotic symptoms or provoked its
occurrence. In schizophrenic patients psychosis could start as
E-PP1131 intoxication psychosis but had a protracted course, there were a
BDNF gene polymorphisms and reduction of exogenous psychotic symptoms and a dominance of
suicidal behavior in schizophrena endogenous, especially syndrome of mental automatism, up to the
Y.K. Kim manifestation of schizophrenic psychosis.
Korea University Ansan Hospital, Department of Psychiatry, Ansan Conclusions.– Thus, the features and structure of stimulant related
city, Republic of Korea psychosis correlate with a diagnosis and have an important differ-
ential diagnostic value.
Background and aims.– Brain-derived neurotrophic factor (BDNF) Disclosure of interest.– The authors have not supplied a conflict of
has possible neurobiologic impact on etiology of schizophrenia. interest statement.
We hypothesizedthat the specific allele or the genotype such as
two single nucleotide polymorphisms (SNPs), 196G/A (rs6265),
11757G/C (rs16917204)is associated with schizophrenia or its clin- E-PP1133
ical features. Homocysteine levels in schizophrenia
Methods.– 241 normal controls and 157 schizophrenia patients correlate with smoking status
are included. The differences in allele or genotype distribution for E. Theochari1 , S. Nikolaou2 , A. Giannoulis3 , F. Louki3 , D. Kipreos4 ,
thepatients and normal controls were analyzed. We also analyzed E. Tsaltas5 , D. Kontis3*
clinical variables among patients. 1 Asklipieion Voulas General Hospital, Psychiatric Department, Voula,
Results.– We found no significant difference in genotype or allele Greece; 2 Thriassion General Hospital, Internal Medicine Department,
distributions of three studied SNPs between the patient group and Elefsina, Greece; 3 Psychiatric Hospital of Attica, Cognitive
the control group. For clinical variables, PANSS, BPRS, and K-CDSS of Rehabilitation Unit- 4th Psychiatric Department, Athens, Greece; 4
each allele or genotype showed no difference among groups. How- Psychiatric Hospital of Attica, Microbiology and Biochemistry
ever, history of suicide attempt was relatively higher in patients Laboratory, Athens, Greece; 5 Athens University Medical School,
with genotype A/A, G/A compared to patients with genotype G/G Experimental Psychology Laboratory, 1st Psychiatric Department,
for 196G/A. Athens, Greece
Conclusions.– Our results suggest that it is possible to use BDNF * Corresponding author.
gene allele and genotype as a predictor for suicide attempt
in schizophreniapatients. It can help manage the schizophrenia Background and aims.– Patients with schizophrenia have higher
patients regarding suicidal behavior and furthermore, mortality. plasma homocysteine levels than controls. Smoking in schizophre-
Disclosure of interest.– The authors have not supplied a conflict of nia is at least two to three times more than that in the general
interest statement. population. We investigated the relationship of plasma homocys-
teine levels with smoking status in schizophrenia.
Methods.– 90 patients with schizophrenia (32 females, mean
age = 42.91 years, SD = 10.1) were recruited during an exploratory
cross-sectional genetic study. Total homocysteine serum lev- Disclosure of interest.– The authors have not supplied a conflict of
els were determined quantitatively by fluorescence-polarization interest statement.
immunoassay. Linear regression analysis examined the effect of
smoking status on plasma homocysteine levels in patients with
schizophrenia and the separate effect of number of cigarettes E-PP1135
smoked on plasma homocysteine. Metabolic syndrome in patients with
Results.– Mean plasma homocysteine levels in patients were 17.44 schizophrenia receiving atypical
(SD = 9.46) ␮mol/lt. 62 patients were smokers and 23 non-smokers
antipsychotics
(72.94% percentage of smokers). Smokers and non-smokers had
E. Kornetova1* , A. Kornetov2 , V. Dubrovskaya1 , M. Arzhanik3 , S.
mean homocysteine levels = 19.08 (SD = 11.14) ␮mol/lt and 13.87
Ivanova4
(SD = 4.48) ␮mol/lt, respectively. Smoking status was significantly 1 Mental Health Research Institute- Tomsk National Research
associated with homocysteine levels (B = 5.204, 95% CI = 0.433,
Medical Center Russian Academy of Sciences, Department of
9.974, t = 2.169, df = 83 p = 0.033) and explained 5.4% of the variance
Endogenous Disorders, Tomsk, Russia; 2 Siberian State Medical
of homocysteine levels in patients with schizophrenia. Smokers had
University, Department of Basic Psychology and Behavioural
5.2 ␮mol/lt higher homocysteine levels than non-smokers. How-
Medicine, Tomsk, Russia; 3 Siberian State Medical University,
ever, the number of cigarettes smoked did not significantly predict
Department of physics with the higher mathematics course, Tomsk,
homocysteine levels.
Russia; 4 Mental Health Research Institute- Tomsk National Research
Conclusions.– Smoking status is correlated with homocysteine lev-
Medical Center Russian Academy of Sciences, Molecular Genetics and
els in schizophrenia, but the effect of smoking does not seem to be
Biochemistry Laboratory, Tomsk, Russia
dose-dependent. * Corresponding author.
interest statement. Background and aims.– Patients with schizophrenia are at high risk
of metabolic syndrome development. Its main criterion is abdomi-
nal obesity which has two components: visceral and subcutaneous.
E-PP1134 Objectives.– to assess changes of the weight and indicators of the
Suicidal behaviour and hopelessness fat content in the organism of patients with schizophrenia receiv-
in patients with schizophrenia and ing atypical antipsychotics, between groups with and without
akathisia metabolic syndrome.
A. Kornetov1* , E. Kornetova2 , A. Goncharova2 , A. Davydov1 , E. Methods.– 116 patients with schizophrenia were examined, they
Koroleva3 , V. Alifirova3 were divided into two groups with (n = 47) and without (n = 69)
1 Siberian State Medical University, Department of Basic Psychology metabolic syndrome according to criteria of IDF. The anthropom-
and Behavioural Medicine, Tomsk, Russia; 2 Mental Health Research etry in two measures with interval of 4 weeks was carried out:
Institute- Tomsk National Research Medical Center Russian Academy measuring the height and weight with calculation of the body mass
of Sciences, Department of Endogenous Disorders, Tomsk, Russia; 3 index (BMI), identification of total and visceral fat with use of non-
Siberian State Medical University, Department of Neurology and invasive bioimpedance analysis, subcutaneous fat with calculation
Neurosurgery, Tomsk, Russia of total adipose tissue with the use of caliperometry. Statistical
* Corresponding author. analysis was conducted using Wilcoxon signed-rank test.
Results.– In the group with metabolic syndrome no statistically sig-
Background and aims.– High risk of suicidal behavior in patients nificant differences of changes in indicators of BMI (p = 0.1921), fat
with schizophrenia is associated not only with the symptoms and content in the organism (p = 0.6943) visceral fat level (p = 0.5408)
signs of the disorder, comorbid depression, but also with adverse were revealed. Only total adipose tissue underwent statistically
effects of antipsychotic therapy. significant change (p = 0.0115). In the group without metabolic syn-
Objectives.– Determining the relationship between parasuicides in drome statistically significant changes across all indicators were
the anamnesis, hopelessness, akathisia, and key clinical character- noted: p = 0.0007, p = 0.0013, p = 0.0113 and p = 0.0087, respectively.
istics of patients with schizophrenia. Conclusions.– With regard to growth of all indicators of fat compo-
Methods.– 71 patients with schizophrenia were examined (37 men nent of the body content in patients with schizophrenia without
(53%) and 34 women (47%)) using Barnes Akathisia Scale (BAS), metabolic syndrome it is necessary to use programs of preven-
Beck Hopelessness Scale (BHS), and PANSS. The BAS was used to tion at the early stage of course of schizophrenia for the purpose of
divide patients by presence or absence of akathisia. Statistical anal- minimization of the risk of its development.
ysis was performed using Pearson’s X2 , and Mann–Whitney U test Disclosure of interest.– The authors have not supplied a conflict of
to compare independent samples and Fisher’s exact test to compare interest statement.
small samples.
Results.– Prevalence of parasuicide in the anamnesis was 36.6%,
akathisia – 38.1%. It has been established that parasuicide occurred E-PP1136
more often in people with an early onset of schizophrenia Prader-Willi syndrome and 22q11.2
(p = 0.0056). Similar results were obtained depending on the deletion syndrome - in search of a
absence or presence of akathisia (p = 0.022). The link between
model for the immuno-inflammatory
parasuicides and akathisia was not found. Patients with akathisia
significally had the same number of points according to BHS as etiology of psychotic disorders
patients without akathisia (p = 0.368), and the level of negative out- M. Krefft1* , B. Misiak2 , D. Frydecka1
1 Wroclaw Medical University, Department of Psychiatry, Wrocław,
look on their own future in both group was characterized by mild
hopelessness. Poland; 2 Wroclaw Medical University, Department of Genetics,
Conclusions.– Constant or occasional feeling of inner restlessness Wrocław, Poland
impairs patient’s health but doesn’t have a significant effect on the
negative attitude towards his/her own future. The obtained data Background and aims.– The contribution of immuno-inflammatory
indicate a huge contribution of clinical characteristics in compar- processes is widely described in the etiology of psychotic disorders
ison with iatrogenic to the origin of suicidal behavior of patients and in the context of risk and clinical manifestation of schizophre-
with schizophrenia. nia spectrum disorders. Prader-Willi syndrome (PWS) is a rare
genetic disorder associated with hyperphagia and monstrous obe- hazards regression and population attributable fraction (PAF) were
sity. 22q11.2 deletion syndrome (22q11DS), previously known as calculated.
several separate conditions (CATCH22, DiGeorge Syndrome), is a Results.– Among the 9,775 people with SSD, the most frequent co-
cluster of congenital malformations with a variable presentation. occurring physical disease systems were neurologic-cardiovascular
Both syndromes constitute a group of ultra-high risk psychosis system (25%), neurologic-endocrine system (21%), and endocrine-
development. cardiovascular system (17%). Combinations of disease systems
The aim is to create a model for the research on the specificity of with highest PAFs were neurologic-cardiovascular disease (PAF:
alterations in the immune system in combination with the analysis 8.3%), neurologic-respiratory disease (PAF: 6.7%), as well as
of their possible impact on cognitive functions in ultra-high risk cardiovascular-respiratory disease (PAF: 6.1%).
psychosis groups. Conclusions.– The current data showed a general increased mortal-
Methods.– Groups of 20 children diagnosed with PWS, 22q11DS ity with different combinations of physical multimorbidity, which
and healthy controls, aged 7-18, were taken under psychiatric and would appear higher than the established mortality risk of individ-
clinical evaluation. 10 ml of fasting blood samples were collected ual conditions. These findings suggest that people with SSD need
and biochemical and inflammatory parameters were designated. to be carefully managed and treated for their physical conditions.
Cognitive functions were evaluated using the Wechsler Intelligence Disclosure of interest.– The authors have not supplied a conflict of
Scale. interest statement.
Results.– The frequency of up to 60% of the occurrence of
schizophrenia or other psychiatric disorders in patients with both
PWS and 22q11DS is described, depending on the research. Prelim- E-PP1138
inary results of the studies on the specificity of immunological and The relation of optical coherence
inflammatory factors present in PWS and 22q11DS in correlation tomography findings with cognitive
with the results of cognitive functions of patients will be presented,
functions and inflammatory
along with the characteristics of mental disorders accompanying
the respective syndrome. biomarkers in patients with
Conclusions.– We hope this study will broaden the knowledge about schizophrenia
both immuno-inflammatory etiology of schizophrenia and psychi- A. Kurtulmuş1* , A. Elbay2 , E.M. Guler3 , C.D. Sahbaz1 , M.H.
atric conditions in rare genetic disorders. Ozdemir2 , I. Kirpinar1
1 Bezmialem Vakif University, Psychiatry, istanbul, Turkey; 2
interest statement. Bezmialem Vakif University, Ophthalmology, Istanbul, Turkey; 3
Bezmialem Vakif University, Biochemistry, Istanbul, Turkey
E-Poster Presentation: Schizophrenia and other Background and aims.– Optical Coherence Tomography (OCT) is a
psychotic disorders - Part VII noninvasive imaging technique and psychiatric use of OCT is rel-
atively new. Decreased thickness of retinal sublayers has been
reported in patients with schizophrenia and it has been thought
that these changes might be a sign of CNS neurodegeneration. The
E-PP1137 aim of our study is to investigate the relation of OCT findings with
Physical health multimorbidity and cognitive functions and inflammatory biomarkers which is thought
its association to mortality rates in to play a role in pathopyshiology of schizophrenia.
people with schizophrenia spectrum Methods.– Fifty schizophrenia patients and 40 healthy controls
were recruited in the study. Wisconsin Card Sorting Test (WCST),
disorders
Stroop Test, Trail Making Test (TMT), Verbal Memory Processes Test
P. Kugathasan1* , H. Wu2 , F. Gaughran3 , R. Ernst Nielsen1 , R.
were applied. Retinal nerve fiber layer (RNFL), ganglion cell layer
Stewart3 , B. Stubbs3
1 Aalborg University Hospital, Psychiatry, Aalborg, Denmark; 2 Centre (GCL), inner plexiform layer (IPL), choroid and macular thicknesses
were recorded. IL-1␤, IL-6 and TNF-a levels were also measured.
for Medical Informatics- Usher Institute of Population Health Sciences
Results.– The levels of all three cytokines were significantly higher
and Informatics, The University of Edinburgh, Edinburgh, United
in the patients (p < 0.001). IPL was found to be significantly thin-
Kingdom; 3 Institute of Psychiatry- Psychology and Neuroscience
ner in patients than the controls (p = 0.04). In patients; choroidal
IoPPN- King’s College London, South London and Maudsley NHS
thickness was reversely correlated with Stroop Word reading time
Foundation Trust, London, United Kingdom
* Corresponding author. (p = 0.04) and positively correlated with immediate memory scores
(p = 0.002). There was also a positive correlation between RNFL
Background and aims.– Physical diseases play a significant role in thickness and immediate memory scores (p = 0.04). There was no
the premature mortality observed in people with schizophrenia relationship between OCT parameters and cytokine levels in the
spectrum disorders (SSD). Despite an increasing awareness of indi- patients.
vidual diseases impact on mortality in patients with SSD, no studies Conclusions.– These findings highlight the association between
have investigated the effect of physical multimorbidity (> two or inflammatory abnormalities and schizophrenia and support the
more physical diseases in the same individual) on mortality. The hyphothesis that OCT parameters might be a sign of central neu-
objective is to investigate the prevalence of different combinations rodegeneration. Further studies are needed to be done with large
of physical disease systems and the association with mortality in sample groups.
people with SSD. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– We conducted a retrospective cohort study using data interest statement.
from South London and Maudsley. The cohort included all peo-
ple with a diagnosis of SSD (ICD-10: F20–F29), who had contact
to secondary services between January 1, 2011 and December 31,
2012. Physical health conditions were ascertained from electronic
patient records any time before follow-up. Follow-up started on
January 1, 2013, and ended on December 31, 2017. Cox proportional
E-PP1139 worse Functionality (FAST 20.3 vs 5.8, p < .001). Patient’s Subjec-
Homicide and schizophrenia in tive Happiness correlated with Functionality (P.374, p = .001) and
Morocco: about 108 cases with the general PANSS (P .295; p = .04), not with the total PANSS,
F. Laboudi nor with the disease awareness (SUMD), performance in general
psychiatry, Psychiatric Ememrgency, Salé, Morocco cognitive tasks nor in social cognition.
Conclusions.– The subjective perception of Happiness and Psycho-
Background and aims.– logical Well-Being of patients with schizophrenia is related to their
Introduction.– The publicity of some medico-legal acts committed functional capacity. The most related clinical dimension are the
by patients with Schizophrenia tends to stigmatize and generalize general symptoms (anxiety, somatic symptoms and mood symp-
in public opinion the fear related to psychiatric pathology. toms), rather than the positive, negative and cognitive symptoms
Aim.– This work aims to describe the different sociodemographic, of the pathology
clinical and criminological profiles of schizophrenic patients who Disclosure of interest.– The authors have not supplied a conflict of
have committed forensic and hospitalized acts at the Psychiatric interest statement.
University Hospital Arrazi in Salé - Morocco in judicial placement
mode after psychiatric assessment.
Means and methods.– We characterized the sociodemographic, clin- E-PP1141
ical and criminological profiles of a population of 108 patients who A cross-sectional relationship
had committed a forensic act and who had already been hospital- between cardiovascular risk factors
ized at the Psychiatric University Hospital Arrazi in Salé during the (CVD risk) and socioeconomic status
period between 1992 and 2018. The statistical study was done by
the software SPSS.20.
(SES) in patients with severe mental
Results.– The profile of Schizophrenics who committed a forensic illness (SMI)
act in our series is characterized by a specific socio-occupational E. Lund-Stenvold* , A. Høye
status (single, childless and unemployed) and by a psychiatric his- The Arctic University of Norway, Department of Clinical Medicine,
tory and violence against people. There is no significant difference Tromsø, Norway
in socio-demographic profile between homicide schizophrenics
and those of other psychiatric disorders. Schizophrenic murder-
ers usually commit only one unpremeditated homicide. One can
Introduction.– Studies show an association between low SES and
then evoke a state of emotional violence. Four criminogenic themes
high CVD risk, with low SES leading to poor health, and low SES
predominated: persecution, the syndrome of influence, mysticism
in patients with SMI. The relationship between SES and CVD risk
and megalomania. Finally, criminal irresponsibility is the rule for
factors in individuals with SMI has, however, not been studied.
psychiatric patients who have committed forensic acts.
Objectives.– To investigate the prevalence of risk factors in patients
Conclusions.– The psychopathology of the morbid process infiltrates
with SMI, adjusted for age and gender, and to estimate the associ-
the forensic act of the psychiatric patient. The appreciation of dis-
ation between CVD risk and SES in patients with SMI.
cernment at the time of the facts should take this into account.
Methods.– Cross-sectional models and linear or multiple regres-
sion analyses will be used to test the association between SES, CVD
interest statement.
risk factors and SMI in a cohort of in- and outpatients in Norwe-
gian specialized health care. Baseline data from two multicenter
E-PP1140 intervention studies are included; “Healthy heart” and “A cluster
randomized study on implementation of guidelines and evidence
Happiness, psychological well-being based treatments of psychoses”. Factors affecting SES such as edu-
and functionality in patients with cational level, habitation and occupation were gathered through
schizophrenia questionnaires. CVD risk was calculated through measurements of
G. Lahera1* , A. Benito2 , A. Raya-Platero3 , S. Diaz-Castillo3 , G. blood pressure, cholesterol levels and levels of blood glucose as well
Junquera1 , L. Gutiérrez-Rojas3 as smoking habits, nutrition and physical activity.
1 University of Alcalá, Psychiatry, Alcalá- Madrid, Spain; 2 Provintial Results.– The study included baseline information sampled from
Hospital of Toledo, Psychiatry, Toledo, Spain; 3 San Cecilio Hospital, 227 + 32500 patients at ten Norwegian hospitals. Analyses are
Psychiatry, Granada, Spain ongoing, and results will be presented at the conference.
* Corresponding author. Conclusions.– The study included baseline information sampled
from 227 + 32500 patients at ten Norwegian hospitals. Analyses are
Background and aims.– The goal of the comprehensive treatment ongoing, and results will be presented at the conference.
of schizophrenia is to increase patient’s functioning. Happiness Disclosure of interest.– The authors have not supplied a conflict of
results from the global balance of the positive and negative affects interest statement.
that mark the life of an individual. Our aim was to analyze
the associated variables to Subjective Happiness in patients with
schizophrenia. E-PP1142
Methods.– Observational, analytical, transversal design, case- Family factors related to admission to
control type. A group of 46 patients with DSM-5 schizophrenia
and 85 healthy controls were assessed in Subjective Happiness,
an acute psychiatric hospital in Sligo,
Well-being, Satisfaction with Life, Functioning, Symptomatology Ireland. A prospective study
and Cognition. J. Tan1* , C. Conlon2 , D. Adamis1
1 Sligo Leitrim Mental Health Services, Psychiatry, Sligo, Ireland; 2
Results.– Patients with schizophrenia had a mean age of 43.2 years,
with 7.3 previous episodes and a mean age of onset of 24 years. They Sligo Medical Academy- National University of Ireland Galway,
presented the following symptomatology: PANSS total 61.4, PANSS Psychiatry, Sligo, Ireland
positive 14, PANSS negative 15.6, PANSS general 31.8 and HAM-D
8.1. Patients had lower scores on the Happiness scale (SHS 4.30
Background and aims.– With the shift from deinstitutionalization
vs 5.45, p < .001), Psychological Well-Being (SPWB, 145.8 vs 154.1,
to community care in psychiatry, relatives of persons with chronic
p < .001), Satisfaction with Life (14.2 vs 19.5, p < .001), and presented
mental health illnesses has had to take over the role as primary
caregivers. Complicated relationships have been observed between no factors were associated with PCS. Among patients with MDD,
the course of the illness and the patient’s family environment; and depressive symptoms were significantly associated with both MCS
the aim is to find out prognostic factors including family factors for and PCS.
readmission to hospital. Conclusions.– Patients with schizophrenia reported better QoL com-
Methods.– A prospective, observational cohort study evaluating pared to patients with MDD. Patients’ mental health, but not
family functioning in patients measured at baseline and followed physical health, reflected the severity of psychotic symptoms
over a one-year period after recruitment, or earlier if admission to among patients with schizophrenia. However, both mental health
the hospital. Sample size consisted of 121 patients from community and physical health reflected the severity of depressive symptoms
who consented to participate in this study. among patients with MDD. The research adds to the understanding
Inclusion.– of symptom severity and QoL among patients with mental illness.
1. patients diagnosed according to or ICD-10 for schizophrenia, Disclosure of interest.– The authors have not supplied a conflict of
schizoaffective disorder or bipolar disorder. interest statement.
2. age 18 years or older
Measurements/scales:
1. Family assessment device (FAD), E-PP1144
2. Perceived Criticism (PC), First psychotic episode in a female
3. Brief Psychiatric Rating Scale (BPRS), taking dietary supplement cocktail
4. Global Assessment of Functioning (GAF) A.F. Teixeira1* , T. Ventura Gil1 , S. Castro2
5. Social Support Questionnaire-6 (SSQ-6). 1 Psychiatry Resident Doctor, Psychiatry and Mental Health
6. Demographics: age, gender, education level, years since first Department- ULS Guarda, Guarda, Portugal; 2 Psychiatrist, Psychiatry
diagnosis and previous admissions was collected. and Mental Health Department- ULS Guarda, Guarda, Portugal
Methods of analysis.– Descriptive statistics, and regression analy- * Corresponding author.
sis performed with outcome variable of admission and predictive
variables for the rest. Background and aims.– People’s interest on dietary supplements,
Results.– Significant differences were found for in terms of age, as a way to improve health and well being, has been increased all
BPRS, FAD score and SSQ total satisfaction level. Those who were over the years. The easy accessibility of these “natural” products
re-admitted to hospital were more likely to be of younger age with a makes important that the physicians keep aware of the virtual side
higher BPRS score, with less social satisfaction and disturbed family effects and interactions resulting of the use of dietary supplements.
dynamics. The clinical case we present emphasizes the value of identifying
Conclusions.– Understanding these factors provides further evi- potential interactions and side effects in a patient taking multiple
dence to the importance of promoting better family functioning supplements simultaneously.
through modified family dynamics, integrating and involving fam- Methods.– Patient’s clinical record and literature review.
ily into the care of such patients. Results.– A 54-year-old female was admitted at the psychiatric
Disclosure of interest.– The authors have not supplied a conflict of department, after being lead to the emergency for exhibiting behav-
interest statement. ioral alterations for the past two months, including increased
speech output, sometimes with soliloquy and unfounded fears
of being disadvantaged by third parties, along with almost total
E-PP1143 insomnia. The patient had no prior history of psychiatric disor-
To compare the quality of life among der. She denied recreational use of tobacco, alcohol or any drugs.
patients with schizophrenia and The physical study, including blood tests and CT-scan showed
no alterations. The described symptoms coincided with the start
major depressive disorder - a cross
of a “treatment” recommended by a “fortune teller”, including:
sectional study “Borututu tea (Cochlospermum Angolensis), Thyme tea, Cranberry
X.W. Tan* , E. Abdin, S. Verma, S. Kang, C. Siow Ann, M. tea, Probiotics, Chamomille + Passionflower + Valerian tea, Cherry
Subramaniam pie + Corn bean + Pink ipê (Handroanthus impetiginosus) tea.
Institute of Mental Health- 10 Buangkok View- Singapore 539747, Conclusions.– The patient remained in recovery for 10 days, treated
Research Division, Singapore, Singapore with: oral Paliperidone 6 mg, and oral Lorazepam 2,5 mg. She had
favorable evolution. At the time of discharge had stabilized levels
of anxiety, fluent speech. No changes in the content of thinking that
Background and aims.– The association of symptom severity with
may be configured as delusional. Regularized sleep cycle. Acquired
quality of life (QoL) among patients with mental illness remains
partial criticism about the initial symptoms.
unclear. We aim to compare QoL and examine the associations of
symptoms severity with QoL among patients with schizophrenia
interest statement.
and MDD.
Methods.– 203 outpatients with schizophrenia and 185 outpatients
with MDD participated in this study. Five-factor model of Positive
E-PP1145
and Negative Syndrome Scale (PANSS) was utilized to assess the
severity of symptoms among patients with schizophrenia and Per- Prevalence of anxiety and depression
sonal Health Questionnaire-8 items (PHQ-8) was utilized to assess in schizophrenics with vs. without
the severity of depressive symptoms among patients with MDD. alcohol abuse
QoL score was collected via 36-item Short Form Survey Instru- A.K. Thammineni
ment (SF-36). QoL scores among participants with schizophrenia Dr NTR university of health sciences, Psychiatry, New delhi, India
and MDD was compared using ANCOVA. Associations of patient
symptoms with QoL were analyzed by multiple regression analyses. Background and aims.– Many studies showed that people drink for
Results.– Compared to patients with MDD, patients with a number of reasons, many of which correspond to the idea of ‘self-
schizophrenia reported better Mental Composite Scale (MCS), and medication’ - i.e. that people believe alcohol alters their mood and
a trend towards better Physical Composite Scale (PCS). Among feelings, and helps them to cope with situations or feelings that
patients with schizophrenia, positive factor, negative factor and they find difficult.
depressive factor scores were significantly associated with MCS and Aims and objectives.– To assess the prevalence of depression and
anxiety in schizophrenics with and without alcohol abuse
Methods.– Sample: A sample of 60 male patients was collected from Disclosure of interest.– The authors have not supplied a conflict of
the patients attending the OPD of Government Hospital for Mental interest statement.
Care, Visakhapatnam
Total 60 patients diagnosed with schizophrenia were taken
–Screened with AUDIT (Alcohol Use Disorders Identification Test)
for alcohol abuse E-Poster Presentation: Schizophrenia and other
Alcohol abuse defined by AUDIT >7 psychotic disorders - Part VIII
–Divided into two groups:
• Group A - Schizophrenics with alcohol abuse
• Group NA - Schizophrenics without alcohol abuse E-PP1147
All the 60 patients were assessed for depressive and anxiety
Malondialdehyde in Tunisian patients
symptoms using Hamilton Depression Rating Scale (HAM-D) and
Hamilton Anxiety Rating Scale (HAM-A) with schizophrenia
Results.– Patients in two groups didn’t show significant variations W. Guidara1 , M. Naifar2 , K. Jmal2 , M. Messedi1 , M. Maalej3* , A.S.
in demographic profiles–8 out of 30 (26.67%) patients from Group A Ellouze3 , S. Omri3 , M. Maalej3 , N. Charfi3 , J. Ben Thabet3 , F. Ayadi1
1 « Molecular bases of human pathology »- Faculty of Medicine of
showed depressive and anxiety symptoms–18 of 30 (60%) patients
from Group NA showed depressive and anxiety symptoms. Sfax, Faculty of Medicine of Sfax, SFAX, Tunisia; 2 Laboratory of
Conclusions.– The results show that symptoms of depression and Biochemistry CHU Habib Bourguiba Sfax, CHU Habib Bourguiba Sfax,
anxiety are more prevalent in schizophrenics without alcohol Sfax, Tunisia; 3 Psychiatry “C” Department - CHU Hédi Chaker Sfax,
abuse–This is a bit contrary to what is generally assumed–There Psychiatry “C” Department, Sfax, Tunisia
are many possible explanations for the pattern of results.
Sleep disturbance and positive symptoms like auditory hal- Background and aims.– There is accumulating evidence of altered
lucinations can cause depression and anxiety features in antioxidant enzyme activities and increased levels of lipid peroxi-
schizophrenics–It’s possible that alcohol, due to its sedative prop- dation in schizophrenia. Evaluate Plasma malondialdehyde (MDA)
erties, relieves the patients of anxiousness and depression caused levels in subjects with Schizophrenia (SCZ) and compare them to
by positive symptoms and sleep disturbance controls.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– This is a case-control study involving subjects with SCZ.
interest statement. The diagnosis was selected based on DSM-5 criteria, Psychological
symptoms were assessed using the Positive and Negative Syn-
drome Scale (PANSS). MDA level was analyzed using colorimetric
E-PP1146
methods as well as in control subjects.
Efficacy and safety of lurasidone in Results.– This study included 45 patients with SCZ (aged 37, 38
adolescents with schizophrenia: years ± 11, 28) and 100 controls (aged 33, 09 ± 9, 48). MDA was
analysis of a 2-year, open-label significantly increased in patients with SCZ compared to controls
extension study (p = 0, 018). MDA was positively correlated with the PANSS score
R. Goldman1 , M. Tocco1* , A. Pikalov1 , D. Ling2 , A. Loebel1 (r = 0,208; p = 0,018), Using the binary logistic regression test, we
1 Sunovion Pharmaceuticals Inc., Medical Affairs, Marlborough, USA; found that increased MDA level was independently associated with
2 Sunovion Pharmaceuticals Inc., Statistics, Marlborough, USA the occurrence of SCZ (OR = 1,899; 95% IC = 1,217 – 2,965), A typical
* Corresponding author. analysis of MDA concentrations in the plasma showed an area under
the curve of 0, 70 ± 0,051 (95% confidence interval, 0,601 to 0,809)
Background and aims.– To obtain long-term data on the safety and and a predictive threshold value of 1,717 ␮M. The sensitivity and
efficacy of lurasidone in adolescents with schizophrenia. specificity of the MDA found were 71, 8% and 51, 2% respectively.
Methods.– Adolescents (13–17 years) who completed 6 weeks of Conclusions.– These results suggest that oxidative stress may be
double-blind (DB), placebo-controlled treatment with lurasidone involved in the pathophysiology of schizophrenia, which may
were enrolled in a 2-year, open-label (OL) extension study in which contribute to increased lipid peroxidation including plasma and
patients were continued on lurasidone 18.5–74 mg/d or switched erythrocyte concentrations in omega 3 and omega 6 may be dis-
from placebo to lurasidone. Efficacy measures included the Posi- rupted, hence the interest to study the profile of fatty acids.
tive and Negative Syndrome Scale (PANSS) total score (responder Disclosure of interest.– The authors have not supplied a conflict of
criteria, ≥20% reduction from DB baseline). interest statement.
Results.– A total of 271 patients entered the 2-year extension study,
of whom 42.4% discontinued prematurely. Mean PANSS total score
was 93.5 at DB baseline, and 76.0 at OL Baseline. Mean change E-PP1148
from DB baseline in the PANSS total score at weeks 52 (n = 189) and The metabolic profile of
104 (n = 156) was −32.4 and −34.3, respectively. Responder rates antipsychotic-free schizophrenic
at weeks 52 and 104 were 92.1% and 91.0%, respectively. During
patients
OL treatment, the most common adverse events were headache
M. Maalej1* , A.S. Ellouze1 , N. manel2 , W. Guidara3 , K. Jmal2 , S.
(24.0%); and schizophrenia, anxiety and nausea (12.5%). Median
Omri1 , M. Maalej1 , F. Ayedi2 , N. Charfi1 , J. Ben Thabet1
change in laboratory parameters from DB baseline to weeks 52 1 Hedi Chaker University Hospital, Psychiatry “C” Department, Sfax,
and 104, respectively, were: total cholesterol, −3.0 and +5.0 mg/dL;
Tunisia; 2 Habib Bourguiba University Hospital, Laboratory of
triglycerides, +11.0 and +14.0 mg/dL; and hemoglobin A1c, 0.0 and
biochemistry, Sfax, Tunisia; 3 Sfax Medical School- University of Sfax,
0.0%. Mean change from DB baseline in weight at week 52 and week
Research Unit “12ES17” « Molecular basis of human pathology », Sfax,
104 was +3.3 kg and +5.0 kg, respectively (vs. expected weight gain:
Tunisia
+3.4 kg and +5.7 kg, respectively, based on CDC growth charts). * Corresponding author.
Conclusions.– In adolescents with schizophrenia, long-term treat-
ment with lurasidone was associated with continued improvement Background and aims.– The high frequency of metabolic distur-
in symptoms of schizophrenia; minimal effects were observed on bances and their cardiovascular complications have become a
body weight, lipids, and glycemic indices. major concern in the management of patients with schizophrenia.
Our objective was to study the metabolic profile of patients with Disclosure of interest.– The authors have not supplied a conflict of
schizophrenia and without antipsychotic medication for at least interest statement.
three months.
Methods.– We carried out a case-control study, from June 2016 to
December 2017, at the psychiatry “C” department of Hedi Chaker E-PP1150
University Hospital. Patients with schizophrenia (SCZ), who had Influence of adherence to therapy of
not taken antipsychotic medication for at least three months before patients with schizophrenic spectrum
admission, were included in the study.
disorders on the frequency of
Results.– Thirty nine patients and 90 controls were included in
the study. The average age of patients and controls were respec- hospitalization in psychiatric hospital
tively 37.87 ± 10,9 years and 35,03 ± 9.49 years. The body mass S. Magzumova
index (BMI) was significantly lower in patients than in con- Tashkent Medical Academy, Psychiatry and Narcology, Tashkent,
trols (22.89 ± 4.14 kg/m2 vs 24.76 ± 2.98 kg/m2, p = 0.012). There Uzbekistan
was no significant difference between the two groups concern- Background and aims.– Studying the degree of adherence to therapy
ing: glycaemia, triglycerides and HDL-cholesterol. However, total in patients with various clinical forms of schizophrenic spectrum
cholesterol was significantly lower in patients (3.64 ± 0.64 mmol/L disorders, assessing the effect of adherence to therapy on the hos-
vs 4.3 ± 1.02 mmol/L; p = 0.003) and so was LDL-cholesterol pitalization rate.
(2.02 ± 0.55 mmol/L vs 2.67 ± 0.82 mmol/L; p < 0.001). Methods.– The study included 100 patients undergoing inpatient
Conclusions.– Our results suggest that schizophrenia could be a pro- treatment on the basis of the City Clinical Psychiatric Hospital of
tective factor against metabolic syndrome. Such a syndrome would Tashkent, according to the diagnostic criteria for schizophrenic
rather be due to the antipsychotic medication than to the illness per spectrum disorders according to ICD-10 (F21.0, F22.0, F23.0, F25.0).
se. Thus, we ought to carefully monitor our patients once we give The age of patients from 18 years. Disease duration at the time of
them antipsychotics. Otherwise, we may do more harm than good. the survey was at least 1 year. The study used: The scale of assess-
Disclosure of interest.– The authors have not supplied a conflict of ment of compliance with the treatment regimen (MARS, Thompson
interest statement. et al., 1999).
Results.– At the first hospitalization, according to the patients them-
selves, only 37 people were aware of the need for maintenance
E-PP1149
therapy (37%), realized but did not follow the recommendations
Smoking in patients with of the attending physician - 51 people (51%), did not realize and
schizophrenia: a frequent addictive did not follow the doctor’s recommendations - 22 people (22%).
behavior Within a year after the first hospitalization, 78 people (78%) were
M. Trigui1 , Y. Mejdoub1 , L. Ghanmi2 , M. Maalej3* , J. Jdidi1 , M. Ben re-hospitalized (78%), of whom, against the background of non-
jema1 , R. Boukhchina2 , M. Abbes2 , K. Zitoun2 , S. Yaich1 , L. Zouari3 , compliance with drug therapy or partial non-compliance, 62 people
J. Damak1 , M. Maalej3 (62%).
1 Hédi Chaker University Hospital, Department of Community Conclusions.– Patients with schizophrenic spectrum disorders dur-
Medicine, Sfax, Tunisia; 2 Regional Hospital of Gabes, Department of ing the first year after the manifestation of the disease in most cases
Psychiatry, Gabes, Tunisia; 3 Hédi Chaker University Hospital, either did not comply with the regimen of drug therapy, or com-
Department of Psychiatry “C”, Sfax, Tunisia pletely stopped taking the drugs, which is combined with a low
* Corresponding author. level of awareness of the need for patients to continue therapy.
Background and aims.– The addictive behaviors are common in interest statement.
patients with Schizophrenia (SZ) and dramatically worsen their
outcome. Our study aimed to describe the epidemiology of addic-
tive behaviors in patients with SZ. E-PP1151
Methods.– We conducted a cross-sectional descriptive study. It con- Demoralization in psychotic patients:
cerned all patients who first consulted the psychiatric department
association with benzodiazepine and
of the regional hospital of Gabes between 1st January 2010 and
31st December 2013. The data was collected using a pre-established positive symptoms
evaluation sheet exploring the patients’ data. The diagnosis of SZ A. Maraone1* , M. Frascarelli1 , L. Carlone1 , F. Ghezzi1 , E. Bruni2 , V.
was coded according to ICD-10 disease categories. Roselli1 , V. Magliocchetti1 , C. Pancheri1 , M. Parisi3 , M. Pasquini1 ,
Results.– We counted 170 cases of SZ (10.6% among all patients L. Tarsitani1
1 Sapienza University, Human Neurosciences, Rome, Italy; 2 Sapienza
consulting in our department). The median age was 34 years
(IQR = [28–42 years]). The sex ratio was 1.98. One hundred and University, Cognitive Neurosciences and Psychological Rehabilitation,
eleven patients with SZ (69.4%) were single. The socioeconomic Rome, Italy; 3 Psychiatric Residential Structure Villa Armonia Nuova,
level was low for 136 (90.7%). Fifty-two schizophrenic patients Head Department, Rome, Italy
(30.6%) had addictive behaviors: smoking (48 SZ, 28.2%), alcohol (1
SZ, 0.1%), smoking and alcohol (2 SZ, 1.2%), and psychotropic drugs Background and aims.– Demoralization is the state of mind of a per-
abuse (1 SZ, 0.1%). Smoking was significantly more common among son deprived of courage, disheartened, who experiences a sense of
patients SZ compared to other psychiatric patients (29.4% VS 15.4%; incompetence. It differs from depression due to lack of anhedonia.
OR = 0.43; p < 10−3 ) and it was significantly more common among Recent studies have hypothesized that a Demoralization Syndrome
schizophrenic men compared to schizophrenic women (43.4% VS (DS) could increase morbidity and mortality in schizophrenia.
1.8%; OR = 0.02; p < 10−3 ). Patient outcome was not significantly The aim of present study is to investigate the prevalence of DS,
different between smoking and non-smoking (p = 0.84). and its association with clinical variables, in a sample of psychotic
Conclusions.– The reason for the high prevalence of smoking among patients.
schizophrenics is unknown, but is likely that smoking behavior in Methods.– The sample consists of 37 patients with a Psychotic
schizophrenia is a complex process, related to numerous inter- Disorder diagnosed with Structured Clinical Interview-DSMV. The
relationships between the psychopathological, biochemical, and Demoralization Scale was employed to misure the Demoralization
neuropharmacological aspects. Index (DI). Depressive and psychotic symptoms were evaluated
through: Patient Health Questionnaire-9 (PHQ-9); Positive and E-PP1153

Negative Symptoms Scale (PANSS). Evolution of bdnf
Results.– 51.3% of the sample showed a DS (DI > 24). No difference
full-length/truncated receptor ratio
in DI were observed between subgroups based on medica-
tions prescribed (F = 1.149; p = 0.344): Antipsychotics (n = 17); and cognitive/general functioning
Antidepressant and Antipsychotic (n = 8); Antipsychotic and Mood after a first episode of psychosis
Stabilizers (n = 9); Antipsychotic, Antidepressant and Mood Stabi- M. Martinez-Cengotitabengoa1* , S. García1 , S. Alberich2 , M.
lizers (n = 3). DI was instead higher (t = 2.479; p = 0.018) in patients Parellada3 , C. Bibiana4 , B. Esther5 , R. Roberto6 , A. Lobo7 , M.P.
who were taking benzodiazepines (54.1% of all sample). According García-Portila8 , M. Bernardo9 , K. McDowell10 , A. Gonzalez-Pinto1
1 CIBERSAM- BioAraba Research Institute- University of the Basque
to PHQ, 27% of patients (n = 10) suffered from depressive symp-
toms. t-test showed higher DI in this group respect to subjects with Country, Psichiatry, Vitoria, Spain; 2 CIBERSAM-BioAraba Research
subtreshold depression (t = 3.162, p = 0.003). A positive correlation Institute, Psychiatry, Vitoria, Spain; 3 Hospital General Universitario
was found between PANSS Positive Symptoms and DI (r = 0.451, Gregorio Marañón School of Medicine- Universidad Complutense-
p = 0.005). IiSGM, Child and Adolescent Psychiatry Department, Madrid, Spain; 4
Conclusions.– In our sample DS is a relevant clinical component and University of Barcelona- Institut d’Investigacions Biomèdiques August
it appears to be associated with more severe positive symptoms Pi i Sunyer IDIBAPS, Department of Psychiatry and Clinical
and prescription of benzodiazepine. DS in our patients is more com- Psychobiology, Barcelona, Spain; 5 Neuropsychopharmacology &
mon than depressive symptoms; however only future studies with Psychobiology Research Group- University of Cadiz. Instituto de
enlarged sample could disentangle DS from depression. Investigación e Innovación en Ciencias Biomédicas de Cádiz- INiBICA-
Disclosure of interest.– The authors have not supplied a conflict of Hospital Universitario Puerta del Mar, Area of Psychobiology.
interest statement. Department of Psychology, Cadiz, Spain; 6 Research Institute of
Hospital 12 de Octubre i+12, Psychiatry, Madrid, Spain; 7 Instituto de
Investigación Sanitaria Aragón and University of Zaragoza,
E-PP1152 Psychiatry, Zaragoza, Spain; 8 Faculty of Medicine- University of
Anosognosia in schizophrenia Oviedo. Instituto Universitario de Neurociencias del Principado de
A. Martin1* , L. Gonzalez2 , M. James3 , N. Abbas4 , K. Frischer5 Asturias INEUROPA, Psychiatry, Oviedo, Spain; 9 Neuroscience
1 Bronx Care Health System, Pyschiatry, New York, USA; 2 James J. Institute- Hospital Clínic de Barcelona, Barcelona Clínic
Peters VA Medical Center, Psychiatry, New York, USA; 3 Bronx Care Schizophrenia Unit-, Barcelona, Spain; 10 Faculty of Medicine-
Health System, Psychiatry, New York, USA; 4 American University of Universidad Complutense de Madrid- Research Institute of Hospital
the Caribbean School of Medicine, Psychiatry, Florida, USA; 5 Kirby 12 de Octubre i+12 & IUINQ, Pharmacology, Madrid, Spain
Forensic Psychiatric Center, Psychiatry, New York, USA
Background and aims.– Inflammatory and neuroplasticity hypothe-
Background and aims.– Anosognosia is the denial of illness or ses have demonstrated their role in the pathophysiology of
failure to appreciate one’s deficits. Anosognosia is common in schizophrenia. Adequate functioning of both signaling pathways
Schizophrenia with a prevalence of approximately sixty percent is crucial to avoid cognitive deterioration in such patients. The
(60%). Numerous individuals diagnosed with Schizophrenia, lack results about the relationship between peripheral levels of BDNF
awareness of and fail to recognize the signs, symptoms and con- and cognitive performance are contradictory. In this study, we
sequences of their illness, which pose significant challenges to hypothesized that the expression of different types of BDNF recep-
clinicians. In this poster, we discuss the barriers to effective tors and its evolution during 1 year would influence general and
treatment of a 49 year old female with Chronic Schizophrenia, cognitive function in patients with a first episode of psychosis (FEP).
noncompliance with psychotropic medications and over twenty Methods.– BDNF full length (TrKB-FL) and truncated receptors’
(20) previous psychiatric hospitalizations, who presents at baseline peripheral levels were assessed in a sample of 97 FEP patients and
with severe lack of insight into her condition. 97 matched healthy controls, and the ratio TrKB-FL/TrKB-T (from
The aim of this presentation is to present a case report and litera- now on FL/T) was calculated for each one. Cognitive and general
ture review of the prevalence of anosognosia in Schizophrenia and functioning was measured at inclusion and 2 years later.
related neurobiological correlates, treatment considerations and Results.– A high baseline ratio FL/T was related to a better cogni-
prognosis associated with this condition. tive functioning (general, verbal memory, working memory and
Methods.– A search of PubMed and ResearchGate databases was premorbid IQ) with a significant interaction with educational level,
employed to select various articles in peer-reviewed journals pub- both with baseline and 2 years cognitive performance. The increase
lished in the past ten (10) years. of the FL/T ratio through the 2 years follow-up period positively
Results.– A review of the literature revealed that lack of insight cor- influenced in general but not in cognitive functioning.
relates with smaller right dorsolateral prefrontal cortex volume, Conclusions.– A higher level of functional BDNF receptor versus the
reduced right posterior insula surface area and impaired connec- truncated one was associated with better cognitive performance
tivity in the anterior cingulate cortex and precuneus. Research has of patients both at the beginning of the disease and after 2 years.
also demonstrated that anosognosia is a poor prognostic factor for The increase in the FL/T ratio meant that patients had better overall
functional recovery in Schizophrenia. long-term functioning.
Conclusions.– The presence or lack of insight is an important pre- Disclosure of interest.– The authors have not supplied a conflict of
dictor of outcome in Schizophrenia. It affects treatment adherence, interest statement.
relapse frequency, symptom remission and risk of violence. It is
imperative that researchers and clinicians recognize the signifi-
cance of treatment measures aimed at improving insight towards E-PP1154
providing favorable outcomes in patients with Schizophrenia. “30 years inside her mind” - a case of a
Disclosure of interest.– The authors have not supplied a conflict of very long duration of untreated
interest statement. psychosis
B.R. Martins Ramos1* , A. Miguel2 , F. Andrade1 , F. Coutinho1 , E.
Osório1,3
1 Centro Hospitalar Universitário de São João, Clínica de Psiquiatria e
Saúde Mental, Porto, Portugal; 2 Centro Hospitalar de Vila Nova de

Gaia e Espinho, Serviço de Psiquiatria e Saúde Mental, Vila Nova de Conclusions.–

Gaia, Portugal; 3 Centro Hospitalar Universitário de São João, 1. The presence of traumatic events (physical punishment, emo-
Departamento de Neurociências Clínicas e Saúde Mental- Faculdade tional abuse and sexual events) is significantly greater in
de Medicina da Universidade do Porto, Porto, Portugal psychotic patients than in the general population.
* Corresponding author. 2. The presence of traumatic experiences, such as emotional abuse
and sexual abuse, is related to the presence of greater positive
Background and aims.– The duration of untreated psychosis (DUP) symptoms, and therefore to a worse prognosis
is defined as the time from the emergence of the first psychotic Disclosure of interest.– The authors have not supplied a conflict of
episode until the initiation of the appropriated treatment. Studies interest statement.
worldwide have shown a large variation in the median DUP, from
4 to 26 weeks.
Our aim is to present a clinical case of a woman with schizophre- E-PP1156
nia, which was symptomatic for 30 years without any psychiatric Mindful disposition is linked to less
treatment and to understand and reflect about what kind of factors
could had played a role in such a long DUP in this case.
hostile attributions in schizophrenia
Methods.– Study, evaluation and treatment of the patient during her spectrum disorders
hospitalization. Systematic review of the literature, using PubMed R. Mediavilla1* , A. Muñoz2 , B. Rodríguez-Vega2 , C. Bayón2 , G.
and the following key-words: first-episode psychosis, schizophre- Lahera3 , Á. Palao2 , M.F. Bravo4
1 La Paz University Hospital. UNED, Psychiatry, Clinical Psychology
nia, duration of untreated psychosis, factors.
Results.– It came to our knowledge that this patient had initiated and Mental Health, Madrid, Spain; 2 La Paz University Hospital,
delusional and hallucinatory symptoms in the beginning of 4th Psychiatry, Clinical Psychology and Mental Health, Madrid, Spain; 3
decade of her life, however she was able to maintain what the family University of Alcalá. CIBERSAM, Medicine, Madrid, Spain; 4 La Paz
considered to be an acceptable social behavior and functioning. University Hospital. UAM, Psychiatry, Clinical Psychology and Mental
Conclusions.– The duration of DUP can influence the prognosis of Health, Madrid, Spain
schizophrenia and it can be influenced by several factors, including
socio-demographic, socioeconomic, clinical and contextual circum-
Background and aims.– Attributional style is a core domain of social
stances, which should be measured. Considering the literature and
cognition that refers to the way one makes inferences about the
developed studies, the explanations found possible for the longer
causes of events. People with schizophrenia tend to perceive more
DUP in this case can be the absence of disruptive behaviour, the fact
intentionality and hostility in other people’s behaviors in negative
that the patient was a single-person household and that she had an
and ambiguous situations than do control groups. Some evidence
occupation for the majority of her life.
suggests that mindfulness may modify the attributional style of
non-clinical populations. However, no studies have explored the
interest statement.
effect of mindfulness on clinical samples. Thus, the current study
examines the association between mindful disposition, attribu-
E-PP1155 tional style, and social functioning in a sample of people with
schizophrenia spectrum disorders (SSDs).
Relationship between psychosis and Methods.– Twenty-three people with SSDs completed the Mindful
childhood traumatic experiences Attention and Awareness Scale (MAAS), the Ambiguous Intentions
L. Mata-Iturralde1* , R. Alvarez Garcia2 , S. Ovejero2 , M. Iza2 , S. Hostility Questionnaire (AIHQ), the Positive and Negative Syn-
Sanchez Alonso2 , L. muñoz lorenzo3 drome Scale for schizophrenia (PANSS), and the Personal and Social
1 Fundacion Jimenez Diaz, Psichiatry, Madrid, Spain; 2 Fundación
Performance scale (PSP).
Jimenez Diaz, Psychiatry, Madrid, Spain; 3 Fundacion Jimenez Diaz, Results.– It was found that higher mindful disposition is linked to
Psychiatry, Madrid, Spain lower attributions of intention and hostility, and that the decrease
in attributions is associated with better social performance (Fig. 1).
Background and aims.– The relationship between early traumatic
events and the presence of psychopathology has been widely
described. However, the study of the relationship between trauma
and psychosis remains to be analyzed extensively.
The aim is to analyze the presence of traumatic events and their
relationship with severity in people with psychosis as well as their
comparison with a group of healthy controls.
Methods.– We selected 2 groups: healthy controls (N = 100) and
people with a diagnosis of psychosis (N = 107). They were evalu-
ated with the ETISR-SF scale (Evaluation of traumatic events before
the age of 18). Cases were also evaluated with PANSS and suicide
attempts were collected.
Results.– The results showed high prevalence and significant dif-
ferences of emotional abuse, sexual abuse and physical trauma
in psychotic patients compared with healthy general population, Figure 1. study of higher mindful disposition.
(psychosis: physical abuse 47.7%, emotional abuse 69.2%, sexual Conclusions.– This study concludes by discussing the lower dispo-
abuse 31.1% versus to healthy: 29% physical abuse, 35% emotional sition toward attributional bias displayed by patients with higher
abuse and 19% sexual abuse). The presence of traumatic events was mindful disposition and the possibility that mindfulness training
associated with worse scores in PANSS positive, especially in cases may modify the attributional style of people with severe mental
where there was sexual abuse or emotional abuse. No relationship illness. The limitations of the study are also indicated.
was found between suicide attempts in psychotic patients and the Disclosure of interest.– The authors have not supplied a conflict of
presence of traumatic events. interest statement.
E-PP1157 matched comparison group of 69 patients was generated from elec-

Altered CRP and DHEAS serum levels tronic health records. We measured symptoms serially with the
in schizophrenia patients with MYMOP-2, the Positive and Negative Syndrome Scale, the MADRS,
the Clinical Global Inventory, and the BASIS. Narrative interviews
metabolic syndrome generated qualitative data.
I. Mednova1,2* , A. Boiko1 , E. Kornetova3
1
Results.– Of our 69 patients, 39 managed psychosis without the use
Mental Health Research Institute, Tomsk National Research Medical
of medication. Another 25 managed well on low-dose antipsychotic
Center of the Russian Academy of Sciences, Laboratory of Molecular
medications. Four individuals required progressively higher levels
Genetics and Biochemistry, Tomsk, Russia; 2 Tomsk State Institute,
of medication and one decompensated. Our patients functioned at
Faculty of Innovative Technologies, Tomsk, Russia; 3 Mental Health
significantly higher levels than the comparison populations and at
Research Institute, Tomsk National Research Medical Center of the
significantly lower levels of medication. The overall cost-benefit
Russian Academy of Sciences, Department of Endogenous Disorders,
was favorable in creating fewer hospitalization, crises, and dimin-
Tomsk, Russia
ished suicidality.
Conclusions.– The results support the idea that motivated patients
Background and aims.– Changes in the hypothalamic-pituitary sys- can engage in an approach that combines integrative medicine,
tem and activation of the immune system play an important role psychotherapy, and conventional medication management in asso-
in schizophrenia pathogenesis. At the same time, stress reactions ciation with involvement of family and friends in a community
and inflammation are predictors of the metabolic syndrome. Dehy- effort and can recover without or with low doses of conventional
droepiandrosterone sulfate (DHEAS) is a hormone reflecting the medications. Not all patients can participate in such a program.
response to stress. C-reactive protein is a marker of inflammation. Disclosure of interest.– The authors have not supplied a conflict of
Objective of this research is to study variation of high- interest statement.
sensitivity C-reactive protein (hsCRP) and DHEAS concentrations
in schizophrenic patients with metabolic syndrome (MetS).
E-PP1159
Methods.– We identified schizophrenic patients with MetS by the
IDF criteria, 2005. Concentration of high-sensitivity C-reactive Associations of psychological
protein (hsCRP) and DHEAS was identified with use of immune- resilience with severity and frequency
enzyme analysis (Vector-Best and AlkorBio Russia). Statistical of attenuated psychotic features,
processing of findings was conducted with use of the program SPSS cognitive biases and depressive
Statistic (V. 17.0).
Results.– The study included 97 persons with schizophrenia (mean
symptoms in young adults at risk of
age 37 ± 10 years, 51 women). Healthy controls (n = 24) included an psychosis
age- and sex-matched cohort without known disease symptoms. ˛ 1* , A. Arciszewska1 , A. Cechnicki1 , D. Frydecka2 , Ł.
D. Metel
The patients with schizophrenia were divided into two groups: ˛ 3
Gaweda
1 Jagiellonian University Medical College, Community Psychiatry
patients with MetS (n = 40) and patients without this syndrome
(n = 55). A significant increase in hsCRP concentration (p = 0.007) Department, Krakow, Poland; 2 Wrocław Medical University,
and decrease in DHEAS concentration (p = 0.010) were observed in Department of Psychiatry, Wrocław, Poland; 3 Medical University of
schizophrenic patients with MetS in comparison to healthy indi- Warsaw, II Department of Psychiatry, Warsaw, Poland
viduals. In addition, we showed a statistical trend (p = 0.057) of
decreased DHEAS concentration in schizophrenic patients without
Background and aims.– Psychological resilience has been under-
MetS in comparison with healthy controls.
studied in the context of psychotic disorders, although it is thought
Conclusions.– It can be assumed that there is an association between
to have a protective function against development of mental dis-
inflammation and stress in pathogenesis of schizophrenia and
orders. Scarce research bring contradictory results pointing out
MetS.
that, on the one hand, resilience is not associated with attenuated
This work is supported by RSF grant N 18-15-00011.
psychotic symptoms, but on the other – its lower levels are more
often observed among individuals who later converted to psychosis
interest statement.
than among those who did not. Moreover, resilience is increasingly
recognized as a cognitive structure, hence it could be related to
E-PP1158 cognitive distortions and depressive symptoms as a link between
depression and biased cognition is now well-established. Our goal
Results of an integrative medicine and is to examine how resilience is related to prodromal symptoms of
psychotherapy approach to patients psychosis.
with psychosis Methods.– 100 individuals aged 18 to 35 meeting clinical high
L. Mehl-Madrona1* , B. Mainguy2 risk criteria for psychosis were examined with Comprehensive
1 University of Maine, Graduate School, Orono, Maine, USA; 2 Assessment of the At-risk Mental State (CAARMS) interview, Pro-
University of Maine, School of Social Work, Orono, USA dromal Questionnaire 16 (PQ-16), Connor-Davidson Resilience
* Corresponding author. Scale (CD-RISC-10), Center for Epidemiological Studies-Depression
Scale (CES-D) and Davos Assessment of Cognitive Biases Scale
Background and aims.– Some patients with the diagnosis of a psy- (DACOBS-18). Pearson’s correlations were applied.
chotic disorder wish to minimize or avoid medications. They are Results.– Preliminary analyses demonstrate significant inverse cor-
seeking a recovery model with the aim of maximizing indepen- relations of resilience with severity and frequency of symptoms
dence and healing. in CAARMS, but lack of association with PQ-16 score. Resilience
Methods.– We report qualitative and quantitative data on a group is associated with jumping to conclusion, belief inflexibility and
of 69 motivated adult patients with psychosis as a proof of con- external attribution biases, as well as depressive symptoms. No sig-
cept study – that management with minimal or no medication nificant correlations were found between resilience and attention
is possible for some. Patients engaged in dialogical psychother- to threat and safety behaviors biases.
apy, medication management, and integrative medicine practices Conclusions.– Psychological resilience is related to the severity
for at least six months. An additional 209 patients presented for and frequency of prodromal psychotic symptomatology, cognitive
treatment but did not continue for six months. An anonymous, biases and depression in young people at risk of psychosis.
Disclosure of interest.– The authors have not supplied a conflict of measured by Self-disturbances Scale (SDS) and their association to
interest statement. auditory and visual hallucinations, measured with Questionnaire
of Psychotic Experiences (QPE).
Methods.– SDS questions are formulated in accordance with Mayer-
E-PP1160 Gross criteria: experience is new/compelling (aberrant salience),
Comparison of long-term reduced access/importance of autobiographical past, emotions
antipsychotic use data from medical occurring independently from self’s volition, foreign agents hav-
ing power over self. We administered the scale to a group
records and national prescription
of patients with schizophrenia (N = 84) and healthy volunteers
register (N = 170). Spearman correlations assessed the association between
J. Miettunen1* , H. Koponen2 , J. Moilanen3 , M. Isohanni1 , E. self-disturbances and hallucinations.
Jääskeläinen1 Results.– Patients with schizophrenia revealed substantially more
1 University of Oulu, Center for Life Course Health Research, Oulu,
self-disturbances as compared to healthy controls (total score dif-
Finland; 2 University of Helsinki, Department of Psychiatry, Helsinki, ferences, Z = −5.83, p < 0.001). The total score of SDS positively
Finland; 3 University of Oulu, Department of Psychiatry, Oulu, Finland correlated with the AH score (p = 0.006) and VH score (p = 0.006).
Total AH score correlated with the items of the self-scale such
Background and aims.– Prescription registers are increasingly as novelty (p = 0.037), lack of control (p = 0.047), compelling with
applied to study long-term use of psychiatric medications. Informa- reality (p = 0.048), reflexivity (p = 0.022), and mental absorption
tion on drugs used during hospital care is missing from the registers. (p = 0.017). VH score correlated with novelty (p < 0.001), inten-
The aim of the current study was to compare cumulative amount sity (p = 0.005), compelling reality (p = 0.15) and mental absorption
of antipsychotics estimated from medical records and prescription (p = 0.012).
register and effect of psychiatric hospital care on these estimates. Conclusions.– The study identified a strong association between
Methods.– The sample was based on the Northern Finland Birth self-disturbances and hallucinatory experiences. A detailed psy-
Cohort 1966 including 54 individuals with psychoses. The data chometric approach allowed to identify the specificities of this
on defined daily dose years (DDDy) of antipsychotics was calcu- association. Supported by the grant projects MH CR AZV 17-
lated for years 1998-2009 independently from medical records 32957Aand MEYS NPU4NUDZ: LO1611.
and nationwide prescription register. Sample was divided to two Disclosure of interest.– The authors have not supplied a conflict of
groups based on psychiatric inpatient care during follow-up (100 interest statement.
or more days vs. others).
Results.– In the prescription database median (maximum) DDDy
E-PP1162
was 5.1 (37.7) and in medical records 6.2 (329.0). The median DDDy
among those who had at least 100 days psychiatric treatment days Scandinavian user perspectives on
during the follow-up (n = 21) was 8.8 in prescription register and three-monthly administrations of
15.0 in medical records. Corresponding figures for others (n = 33) antipsychotic medication
were 3.6 and 2.0. The Spearman’s rank correlation for the two DDDy J. Møllerhøj1* , B. Hedberg2 , L.O. Stølan1 , A. Erdner3 , K. Stahl4 , J.
variables was 0.77 for those who had been hospitalized at least 100 Riise5 , E. Jedenius6 , M. Själin7 , M.B. Rise8
days and 0.86 for others. 1 Competence Centre for Forensic Psychiatry, Mental Health Centre
Conclusions.– This was the first study comparing prescription reg- Sct. Hans, Roskilde, Denmark; 2 Jönköping Academy for Improvement
ister and medical records regarding psychiatric medication use. of Health and Welfare, Hälsahögskolan, Jönköping, Sweden; 3 Ersta
Prescription register lack substantial amount of antipsychotics Sköndal Bräcke University, Department of Health Care Sciences,
among those who have had long periods in psychiatric hospitals, Stockholm, Sweden; 4 Janssen Cilag AS Norway, Medical Department,
whereas among those with less hospital days medical records lack Oslo, Norway; 5 Janssen Cilag AS Denmark, Medical Department,
information. Constructing accurate estimates of lifetime antipsy- Birkerød, Denmark; 6 Janssen Cilag AS Sweden, Medical Department,
chotics use require data both from medical records and prescription Stockholm, Sweden; 7 Janssen Cilag AS Sweden, Medical Department,
registers. Stockholm, Sweden; 8 Norwegian University of Science and
Disclosure of interest.– The authors have not supplied a conflict of Technology, Department of Mental Health, Trondheim, Norway

E-PP1161 Introduction.– Knowledge on user perspectives and experiences
An association between with long acting anti-psychotic injections is sparse. Studies tend to
focus on user satisfaction or perspectives of health professionals.
self-disturbances and hallucinations
Objectives.– The aim is to illuminate user experiences when switch-
in schizophrenia: a psychometric ing from monthly to three-monthly injection with paliperidone
approach palmitate (PPM3).
Y. Zaytseva1 , J. Melicharova1 , E. Kozáková1 , E. Šimková1 , I. It is assumed that less frequent injections will affect adherence, per-
Mikriukov1 , K. Schinková1 , F. Španiel1 , A. Mishara2 , P. Mohr MD, ceived quality of life as well as levels of functioning and relations
PhD1* with family or social network. Furthermore, less frequent injections
1 National Institute of Mental Health, Applied Neurosciences and
might also affect the number or character of contacts with men-
Brain Imaging, Prague, Czech Republic; 2 The Chicago School of tal health services and consequently also the identity as service
Professional Psychology, na, Los Angeles, USA user/patient and the perception of their illness.
Methods.– Multi-country study based on semi-structured research
interviews with patients from Scandinavian countries suffering
Background and aims.– From clinical observations, the first rank from schizophrenia. It is an ongoing study. Recruitment of patients
symptoms in schizophrenia (K Schneider) imply self-disturbances continues until data saturation is met. Interviews are transcribed
penetrating psychotic experiences. To date, there are no studies verbatim; main themes and patterns will be condensed and syn-
using psychometric tools to address the issue to what extend these thesized in a qualitative analysis.
association is present in patients with schizophrenia. In the cur- Results.– Preliminary results indicate that most of the informants
rent study, we aimed to assess the frequency of self-disturbances, point towards increased levels of functioning due to this type of
treatment. The three-month frequency seems to increase quality Background and aims.– In view of increased prevalence of audi-
of life in terms of “increased autonomy”. The treatment scheme tory hallucinations in hearing impaired patients, we investigated
also seems to reduce fear of relapse, and the feeling and experience whether it is arising out of the pathology in brain secondary to
of being ill is diminished. Number of contacts with mental health auditory deficits and whether it shares the same phenomenology
services seems not affected. as patients without any hearing impairment.
Conclusions.– The study illustrates that service users suffering from Methods.– We evaluated the phenomenology of auditory halluci-
severe mental illnesses are quite willing to participate in research nations in the patients having Severe Mental Illness with (n = 20)
interviews, and to share their experiences. and without Hearing Impairment (n = 20). The experience was eval-
Disclosure of interest.– The authors have not supplied a conflict of uated across 62 domains, and compared across both groups using
interest statement. MUPS (The Mental Health Research Institute Unusual Perceptions
Schedule) and PSYRATS (Psychotic Symptom Rating Scale).
Results.– Irrespective of the hearing status, patients heard voices
E-PP1163 mainly in the language that they had learnt first (80%). However,
Can cluttering be confused with a few experienced hallucinations in languages they did not know.
schizophrenia? A challenge for In both groups voices of males or both- male and female together
diagnosis and treatment (85%) were most common phenomenon. The hearing impaired
M. Łukasik, J. Milczarek, A. Skiba, J. Mossakowska-Wójcik, M. group experienced auditory verbal hallucination more in the hear-
Talarowska* ing impaired side, coming from inside the mind, ‘as if’ stuck or
Medical University of Lodz, Department of Adult Psychiatry, Łódź, repetitive and they had no emotional salience with the voices. Fur-
Poland ther, in them the intensity of the hallucinatory voices remained the
* Corresponding author. same on closing the affected ear or both the ears as compared to
hearing normal group however use of hearing aids attenuated the
Background and aims.– Cluttering is a fluency speech disorder, intensity of the hallucinations.
that involves excessive breaks in the normal flow of speech and Conclusions.– The phenomenology of auditory hallucination differs
seems, to result from disorganized speech planning, talking too among the two groups. In hearing impaired patients how the brain
fast or in spurts or simply being unsure of what one wants to locates events and sensations in space and time may be a funda-
say. Cluttering often occurs along with stuttering. One of several mental defect, underlying the experience of hallucinations.
diagnostic features of schizophrenia is an impairment of verbal Disclosure of interest.– The authors have not supplied a conflict of
communication which is described in psychpathology as formal interest statement.
thought disorder. Many symptoms have been described: circum-
stantiality, clanging, loose assosiation, distactible speech, flight of
ideas, loss of goal, neologisms, perseveration, pressure of speech, E-PP1165
stilted speech. It is often a symptom of mania, autism or use of Tardive dyskinesia in community
psychoactive substances. The aim of the study was to present a dwelling patients with severe and
case of a patient with cluttering who has been misdiagnosed and
treated for schizophrenia.
enduring mental illness in Sligo area:
Methods.– Case report frequency and associations
Results.– A 26-year-old male was admitted to the hospital with F. Saleem* , J. Tan, D. Adamis
labile affect, socially inappropriate behaviour. The patient was diag- Sligo Leitrim Mental Health Service, Department of Psychiatry, Sligo,
nosed with schizophrenia six years before to his admission and has Ireland
been receiving antypsychotic drugs and mood stabilizers. He did
not meet the ICD-10 or DSM-V criteria of schizophrenia or bipo-
Background and aims.– Tardive Dyskinesia (TD) is a form of invol-
lar disorder. During the initial evaluation the patient presented
untary repetitive muscle movements most commonly due to
hyperactivity, high distractibility. He was extremely talkative, with
antipsychotic exposure. TD is irreversible for most patients and can
several speech fluency disorders such us: rapid and irregular speak-
reduce quality of life, lead to functional impairment, and affects
ing rate, phonological errors, mispronaunciation, confusing and
compliance to treatment.
disorganized language.
Evaluate the frequency and associations of TD in a cohort of patients
Conclusions.– Massive verbal communication impairments, abnor-
who have chronic mental illness and on long term antipsychotics.
mal behavior and a decreasedability to understand reality led to
Methods.– Data extracted from database of patients who attended
a diagnosis of schizophrenia and antipsychotics became the pri-
metabolic clinic. This includes demographics, diagnosis, and med-
mary modality of treatment. Documented pharmacotherapy was
ication. Abnormal movements evaluated with the Abnormal
associated with a lack of adequate improvement.
Involuntary Movement Scale (AIMS).
Results.– Seventy-two participants, 40 (55.6%) males with mean age
interest statement.
of 55.3 (SD: 13.2). Forty-three (59.7%) has diagnosis in the F20 ICD-
10 category, 24 (33.3%) in F30 and 5 (7%) in others. New generation
antipsychotics was prescribed in 56 (77.8%), typical antipsychotics
E-Poster Presentation: Schizophrenia and other in 10 (13.9%) and 6 (8.3%) none; while 14 (19.4%) had two antipsy-
psychotic disorders - Part X chotics and the rest were on monotherapy. No indication of TD
on 45(62.5%) participants while 27 (37.5%) had identified with TD.
TD was significantly more to those who is taking the old gener-
ation (x2 = 8.139 df: 1, p = 0.004). After controlling for the other
E-PP1164
variables, (number of antipsychotics, years since the onset of the
Auditory hallucinations in patients disorder, class of antipsychotics, ICD-10 Diagnosis, gender, num-
with severe mental illness with and ber of admissions, and age), significantly independent predictors
without hearing impairment for the AIMS score were age (t = 2.187, p = .032) and class of antipsy-
K. Sadh* , U. Mehta, M. Keshavan, N.S. Shankar, S. Jain chotics (t = 2.545, p = .013)
National Institute of Mental Health and Neurosciences, Psychiatry, Conclusions.– Advanced age and class of antipsychotics are more
Banglore, India likely to be associated with TD independently of the diagnosis.
However, newer generation antipsychotics cannot be exempted tive domains most compromised in psychosis (Guimond, 2016;
from the association with TD. Knowles, 2015; Park, 2014). The present meta-analysis study aims
Disclosure of interest.– The authors have not supplied a conflict of to analyze the magnitude of effect of cannabis use on the execu-
interest statement. tive function, verbal and working memory performance of patients
with FEP.
Methods.– Manuscripts from the last ten years (2008-2018) were
E-PP1166 identified through extensive literature searches using six online
A narrative meta-synthesis of how electronic databases: PubMed, Sciencedirect, Web of Knowledge,
people with schizophrenia experience Wiley Cochrane Library, PsycInfo (EBSCOHost) and Springerlink.
Studies only focused in cannabis use were selected and studies on
facilitators and barriers in using
poly-substance use were excluded in order to avoid the influence of
antipsychotic medication – confounding variables. The examination of the full texts of the 110
implications for healthcare studies led to the inclusion of 7 studies, with 14 independent sam-
professionals ples (304 cannabis user and 369 cannabis nonuser FEP patients),
M. Salzmann-Erikson1* , M. Sjödin2 and 52 effect sizes in the current meta-analysis. Standardized mean
1 University of Gävle, Faculty of Health and Occupational Studies- differences were computed for each cognitive domain between
Department of Health and Caring Sciences, Gävle, Sweden; 2 cannabis user and nonuser patients. We employed a meta-analytic
Northern Stockholm Psychiatry, Section for Affective Disorders, three level model to combine effect sizes across studies.
Stockholm, Sweden Results.– Table 1 shows that there were not significant effects in any
* Corresponding author. of the cognitive domains between the user and non-user groups.
Background and aims.– It is recognized that people who are diag-

nosed with schizophrenia often do not fully adhere with their
antipsychotic prescription. The vast majority of previous research
on the topic of medical adherence is limited to quantitative research
methods, and in particular, to determining correlations.
Objectives.– The present review was designed to describe how peo-
ple who are diagnosed with schizophrenia experience and narrate
pharmacological treatment with antipsychotic medication.
Methods.– A narrative meta-synthesis. Data sources/review
method: A search was conducted in three databases, PubMed,
CINAHL and PsycINFO, to identify qualitative original research. Nine Table 1. Analyses of the effects of cannabis use in the domains
articles met the criteria for inclusion and were subjected to a qual- executive function, verbal memory and working memory.
itative interpretive meta-synthesis.
Results.– The findings showed that patients were uninformed about Conclusions.– Cannabis use is not related to the executive func-
medication but valued talks about medication with professionals. tioning, verbal and working memory of FEP patients. However,
The findings also demonstrated that patients are motivated to take doses and different types of cannabis preparations may interfere
medication in order to gain stability in their life and to be able to the present results. Future studies may examine the extent of these
participate in life activities and in relationships. Good support, both moderator variables.
from relatives and professionals, also motivates them to continue Disclosure of interest.– The authors have not supplied a conflict of
taking medication. The obstacles were side effects, pressure and interest statement.
compulsion, and rigid organizations.
Conclusions.– We advise professionals to adopt a person-centered
approach to healthcare when encountering these patients and to E-PP1168
transform the language used to describe patients from terms denot- Self-rated quality of life among
ing compliance and adherence to terms denoting cooperation and adolescents experiencing
alliance. Labeling patients as compliant or non-adherent may risk cognitive-perceptive basic symptoms
fortifying preconception of patients as static beings and obscure
the patients’ individual recovery process.
and cognitive disturbances
A. Sebela* , P. Svancer, P. Knytl, J. Jonas, V. Vorackova, A. Dorazilova
National Institute of Mental Health, Diagnostics and Treatment of
interest statement.
Mental Disorders, Klecany, Czech Republic
E-PP1167
Background and aims.– Basic symptoms (BS) are subtle, subjec-
Verbal memory, executive function tive, qualitative changes in mental processes. Two criteria for the
and working memory in cannabis identification of BS were developed: cognitive-perceptive basic
user and nonuser patients with first symptoms (COPER) and cognitive disturbances (CODGIS). These cri-
episode psychosis teria were recommended by European Psychiatric Association for
T. Sanchez-Gutierrez1* , B. Fernandez-Castilla2 , S. Barbeito1 , J.A. psychosis risk assessment. BS have been mainly used in neurobi-
Becerra-Garcia1 , A. Calvo1 ological studies of psychosis. The effect of presence of BS on daily
1 Health Science Faculty, Universidad Internacional de La Rioja- and social functioning is still not well described. The purpose of this
UNIR, Madrid, Spain; 2 Faculty of Psychology and Educational study was to examine if the COPER and CODGIS presence negatively
Sciences, KU Leuven, University of Leuven, Lovaina, Belgium influence the self-rated quality of life (QoL).
* Corresponding author. Methods.– Adolescents from general population in Prague were
assessed by the Schizophrenia Proneness Instrument, the KID-
Background and aims.– The implications of cannabis use in the SCREEN 52, and the KSADS.
cognitive symptoms of patients with first episode psychosis (FEP) Results.– The dataset for this interim analysis consists of 13 ado-
remains uncertain (Arnold, 2015). Working memory, executive lescents with COPER and CODGIS (8 female; 17.9 ± 0.9 y), 9 with
function and verbal memory are three of the neurocogni- only COPER (3 female; 17.3 ± 1.1 y), and 18 adolescents without
BS (11 female; 17.6 ± 0.9 y). Groups did not differ in age (F = 1.265; E-PP1170
p = 0.29) and sex (2 = 2.203; p = 0.33). Groups differed in current Exploring the internal structure of
psychopathology (2 = 7.135; p = 0.03), post-hoc tests showed that
referential thinking in a clinical group
COPER and CODGIS and COPER only groups differed (p = 0.046). The
COPER and CODGIS group scored significantly lower in total KID- 1 University of Cádiz, Department of Psychology, Puerto Real, Spain; 2
SCREEN52 score (effect size, Hedges’ g = 0.90; p = 0.03), dimensions:
University of Seville, Personality- Evaluation and Psychological
Psychological Well-being (g = 1.02; p = 0.01), Parent Relations and
Home Life (g = 1.14; p = 0.008), and School Environment (g = 1.17; * Corresponding author.
p = 0.009) than group without BS. No other significant between
group differences were found. Background and aims.– The REF referential thinking scale is a mea-
Conclusions.– The QoL among adolescents experiencing cognitive- sure which evaluates both ideas of reference common in most
perceptive basic symptoms and cognitive disturbances is lower people and those which indicate a relevant clinical condition. In this
than in adolescents without basic symptoms. Supported by projects study, we proposed to explore the internal structure of the Referen-
18-03125S and LO1611. tial Thinking Scale (REF), to find reliability indicators and evidence
Disclosure of interest.– The authors have not supplied a conflict of of concurrent and divergent validity in a sample of patients with
interest statement. diverse psychopathologies.
Methods.– There were 676 participants (59% women) with various
diagnoses (154 with schizophrenia and other psychotic disorders).
E-PP1169 Their ages varied from 18 to 79 years (Mage = 34.63, SD = 12.44).
Coping, treatment motivation and Results.– Exploratory Factor Analysis found a five-dimension
psychosocial functioning in structure explaining 52% of the variance. The factors extracted
schizophrenia: testing mediator and were: (1) Songs, newspapers, books, (2) Causal explanations,
(3) Guilt, Shame, (4) Attention, Appearance, and (5) laughing,
moderator effects commenting. The ordinal alpha for the complete scale was .97.
N. Semenova1* , A. Komissarov2
1 A strong relationship was found between the REF Scale and
Moscow Research Institute of Psychiatry MoH RF, Outpatient
the positive dimension of the CAPE Scale (r = .656) and aber-
Psychiatry, Moscow, Russia; 2 Freelance Statistics Job, Statistical
rant salience (r = .556) and a weak relationship with anxiety
Consultant, Moscow, Russia
* Corresponding author. (r = −125) and depressive (r = .199) symptomatology. The confir-
matory factor analysis corroborated the results with adequate
Background and aims.– Schizophrenia is characterized by impair- goodness-of-fit indicators (CFI = .984, NNFI = .983, RMSEA = .55
ments in motivation and coping as well as decrements in [.05, .06]).
psychosocial functioning in major life areas. One important factor Conclusions.– The results provide satisfactory evidence for the use
that has received increasing attention in schizophrenia is treatment of the REF scale in identification of ideas of reference in patients
motivation. with diverse psychopathological disorders.
This study examined the nature of the relationships among treat- Disclosure of interest.– The authors have not supplied a conflict of
ment motivation, coping, and psychosocial functioning for persons interest statement.
with schizophrenia. Hypotheses concerning both mediator and
moderator mechanisms were tested.
Methods.– 138 individuals diagnosed with schizophrenia were E-PP1171
recruited as they were admitted to outpatient and inpatient psy- Factors on the referential thinking
chosocial rehabilitation programs in Moscow-based psychiatric scale in discriminating diagnosis of
hospital. The following measures were used: measures of moti- schizophrenia
vation were administered at baseline by testers blind to scores C. Senín-Calderón1* , J.F. Rodríguez-Testal2
on other study variables; measures of coping (COPE, CERQ) and 1 University of Cádiz, Department of Psychology, Puerto Real, Spain; 2
psychosocial functioning (PSP, EQ5D5L, SF36, Q-Les-Q-18) were University of Seville, Personality- Evaluation and Psychological
administered at baseline. Data were analyzed using latent construct Treatment Department, Seville, Spain
modeling to test for mediator and moderator effects. * Corresponding author.
Results.– There were strong bivariate relationships between coping,
motivation, and psychosocial functioning. The results demon- Background and aims.– Referential ideas are common in the general
strated that coping strongly mediated the relationship between population, but they are especially high in certain disorders, such as
motivation and psychosocial functioning. This mediation was evi- in psychotic spectrum. This study intended to identify the factors on
denced by: (a) the direct path from motivation to functional the Referential Thinking Scale (REF) which best discriminate sub-
outcome no longer being statistically significant after the intro- jects with psychotic disorders from those with no psychopathology.
duction of coping into the model; (b) the statistical significance Methods.– There were 2480 participants from the general popula-
of the indirect path from motivation through coping to functional tion (63.2% women, Mage = 31.56, SD = 12.38) and 154 participants
outcome. There was no support for the moderation hypotheses. with diagnosis of schizophrenia (33.8% women, Mage = 38.56,
Conclusions.– Motivation influences psychosocial functioning SD = 12.24).
through its relationship with coping. Coping is a critical mechanism Results.– A stepwise binary logistic regression analysis was
for explaining the relationship between motivation and psychoso- performed in which the dependent variable was diagnosis of
cial functioning. Implications for the theoretical understanding and schizophrenia over age and sex in the first step, followed by five
psychosocial treatments in schizophrenia are discussed. factors from the REF scale. Older age (OR = 1.05 [95% CI = 1.03,
Disclosure of interest.– The authors have not supplied a conflict of 1.06]), male gender (OR = 0.36 [95% CI = .23, .55]), “causal explana-
interest statement. tions” (OR = 1.79, [95% CI = 1.51, 2.12]), “laughing and comments”
(CR = 1.69, [95% CI = 1.48, 1.44]) and “songs, newspapers and
books” (CR = 1.22, [95% CI = 1.03, 1.44]) discriminated patients with
schizophrenia from participants with no psychopathology. This set
of variables explained 44% of the variance.
Conclusions.– Although ideas of reference may be found on a con- 1 Department of Psychological Medicine, University Hospital Center
tinuum in the general population, scoring high on the factors Zagreb, Zagreb, Croatia; 2 Psychiatric Hospital “Sveti Ivan”,
“causal explanations”, “laughing, comments”, “songs, newspapers Department for Integrative Psychiatry, Zagreb, Croatia
and books”, can alert to a possible high-risk mental state. The “guilt * Corresponding author.
and shame” and “attention and appearance” factors did not dis-
criminate. Background and aims.– Atypical long-acting injectable antipsy-
Disclosure of interest.– The authors have not supplied a conflict of chotics (LAI) have become the mainstay of maintenance treatment
interest statement. for patients with schizophrenia. However, there are still barri-
ers to their use in patients with recent-onset schizophrenia. The
majority of current clinical guidelines still do not provide clear rec-
E-PP1172 ommendations, although there is growing support for their use in
Clozapine-induced priapism in a recent-onset schizophrenia.
To compare the efficacy of once-monthly paliperidone palmitate
40-year man with diagnosis of
(PP1M) and atypical oral antipsychotics (AOA) in patients with
treatment-resistant schizoaffective recent-onset schizophrenia.
disorder with no previous history of Methods.– In a retrospective cohort study, we screened all patients
priapism on antipsychotics admitted to the Centre for integrative psychiatry in the Psychi-
H. Shahpesandy1* , U. Prabhakaran1 , T. Al-Kubaisy2 , R. atric Hospital “Sveti Ivan,” from January 2015 to December 2017.
Mohammed-Ali1 , U.S. Ramaiah2 , M. Anene2 The subpopulation of patients with recent-onset schizophrenia was
1 Lincolnshire NHS Foundation Trust, The Hartsholme Centre, Lincoln, defined by time since diagnosis (≤3 years) and the number of pre-
United Kingdom; 2 Lincolnshire NHS Foundation Trust, Peter vious psychiatric hospitalizations (≤3). The number of psychiatric
Hodgkinson Centre, Lincoln, United Kingdom rehospitalizations 12 months after the discharge was used as a
* Corresponding author. measure of treatment efficacy.
Results.– A total of 235 patients with recent-onset schizophre-
Background and aims.– Clozapine is effective in treatment resistant nia were identified, 91 treated with PP1M [median (IQR) age 27
schizophrenia, and among the serious but rare side effects of cloza- (22–33)], and 144 treated with the AOA [median (IQR) age 30
pine is priapism, which is estimated < 1/10,000. Priapism is thought (22–38)]. After the adjustment for a large number of possible
to be caused by blockage of alpha-1 adrenergic receptors. It is a uro- sociodemographic and clinical confounders, patients treated with
logical emergency and can lead to permanent damage to the penis, PP1M had almost 60% lower odds for the psychiatric rehospital-
and impotence. ization during the 12 months after the discharge [OR = 0.41 (CI95%
We present a rare case of 40-year old gentleman with of refractory 0.18–0.92; p = 0.035)].
schizoaffective disorder with clozapine induced priapism. Conclusions.– The observed superiority of PP1M over AOA in the
Methods.– This is a case study. lower rehospitalization rate provides further evidence for the use
Results.– Patient admitted to the psychiatric intensive care unit of atypical long-acting injectable antipsychotics in the treatment
in May 2018 and currently inpatient. Since admission he has of recent-onset schizophrenia.
required eight episodes of seclusion due extreme agitation. He Disclosure of interest.– The authors have not supplied a conflict of
failed to respond to a number of antipsychotics, however, his men- interest statement.
tal state improved on the combination of zuclopenthixol, Valproic
acid, clonazepam, and promethazine. Because of side effects of
zuclopenthixol and preferring oral tablets, and past good response E-PP1174
to clozapine; on 28th June 2018 he was commenced on clozapine, Synthetic cannabinoid-induced
titrated to 300 mg/day within 14 days. He made marked progress
psychoses in hospitalized patients:
after three weeks, however, on 21st July, exactly 23 days post
clozapine he reported a prolonged, 12-hour painful erection. At clinical characteristics and patient
the emergency department, clozapine-induced priapism was con- profile
firmed; patient received penile block and aspiration. Clozapine was V. Skriabin* , M.A. Vinnikova
immediately stopped. Moscow Research and Practical Centre on Addictions of the Moscow
Conclusions.– Patient refused to be re-challenged on clozapine, and Department of Healthcare, Department No.16, Moscow, Russia
currently is being treated with combination of Paliperidone, risperi-
done and Valproic acid, but remains depressed and with number of
Background and aims.– As the classification of synthetic cannabi-
negative symptoms. The dilemma is what to do next, as patient is
noid (SC)-induced psychoses is still a controversial issue, this study
partially responsive to current treatment regime; to recommence
aimed to evaluate SC-induced psychoses in terms of patient profile
him on clozapine or pursue alternative medications.
and clinical characteristics with reference to their follow-up.
Methods.– A total of 46 male patients (n = 46; mean (standard
interest statement.
deviation [SD]) age: 23.2 (3.5) years) diagnosed with psychotic
disorder induced by the SC use who were hospitalized at the inten-
E-PP1173 sive care unit or emergency department of the Moscow Research
and Practical Centre on Addictions of the Moscow Department of
Once-monthly paliperidone palmitate
Healthcare were included in this single-centre, longitudinal, obser-
and oral atypical antipsychotics in the vational cohort study. The catamnestic follow-up period was up to
treatment of patients with 2 years.
recent-onset schizophrenia, Croatian Results.– We evaluated different clinical cases of SC-induced
retrospective cohort study psychoses and identified four clinical types of them. Then we per-
I. Šimunović Filipčić1* , K. Matić2 , N. Gereš2 , J. Gerlach2 , D. formed a catamnestic follow-up of patients to reveal the possible
Prskalo-Čule2 , T. Zadravec Vrbanc2 , V. Lovretić2 , D. Librenjak2 , E. schizophrenic process manifestation in patients who use SC.
Ivezić2 , M. Čelić Ružić2 , V. Grošić2 , S. Vuk-Pisk2 , Ž. Bajić2 , I. Conclusions.– Our findings revealed psychotic disorders to be a typi-
Filipčić2 cal outcome for the SC intoxication. Psychotic disorders developing
in SC intoxication associate with several nonspecific characteris-
tics. In conclusion, we described the signs allowing determining a To investigate a predictive role CYP2D6*4 and CYP2D6*10 as
diagnosis of SC-induced psychosis. biomarkers treatment resistant schizophrenia.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– 130 patients were included into the study, male (65,4%)
interest statement. and female (34,6%), in age from 18 to 60, with a diagnosis from cat-
egory F20 according to ICD-10. The psychotic state of patients was
assessed by PANSS and CGI-S. Patients were divided to 2 groups: (1)
E-PP1175 TRS (2) no TRS. The dividing of patients was carried out according
Insight in SCH: correlation with to the following criteria:
executive functioning • patients with an inadequate response to 2 antipsychotics (at least
R. Softic1* , A. Sutovic2 , E. Becirovic2 , E. Avdibegovic2 , M. Mirkovic one of which is an atypical antipsychotic;
Hajdukov2 • patients with persistent suicidality.
1 University Clinical Center Sarajevo, Department of Psychiatry, Results.– After determining the carrier of polymorphic variants of
Sarajevo, Bosnia, Herzegovina; 2 University Clinical Center Tuzla, CYP2D6, it was found that 55.4% were homozygous for the CC
Department of Psychiatry, Tuzla, Bosnia, Herzegovina allele, and 44.6% had of the CT genotype of polymorphic variant
* Corresponding author. rs1065852. 66.9% were homozygous for the GG allele, and 33.1%
had the GA genotype of the polymorph variant rs3892097. There
Background and aims.– Introduction: duration of illness and execu- were no differences in the carriage of genotypes between groups
tive brain functions may be linked with level of insight. (p < 0,05).
Objective.– To establish a level of insight in subjects with Conclusions.– Thus, we did not detect the effect of CYP2D6*4 and
schizophrenia and compare it with executive functioning, with CYP2D6*10 polymorphisms on TRS. The reason may be that the TRS
regard of duration of illness. is not only related to pharmacogenetics factors. Despite, it is neces-
Methods.– A cross-sectional study was conducted on 60 consecutive sary to study the relationship of other genetic polymorphisms with
outpatients with schizophrenia. Two groups were formed regard- TRS.
ing the duration of illness (≤2 years, and >3 years). All the patients Disclosure of interest.– The authors have not supplied a conflict of
were in clinical remission of illness. The level of insight was estab- interest statement.
lished with Self appraisal of illness questionnaire – SAIQ. Executive
functions were assessed with Wisconsin card sorting test, and two
subscales of Wechsler test of intelligence – WB-II “Similarities” and E-PP1177
“Calculating”. The impact of tobacco smoking on
Results.– Total insight score was 41.73 ± 7.99 which is equivalent to cognitive performance in patients
moderately impaired insight. Mean score on Wisconsin card sorting
with schizophrenia
test (T score) was 33.88 ± 6.63, and represents moderate impair-
F. Stramecki1* , K. Kotowicz1 , P. Piotrowski1 , D. Frydecka1 , J.
ment of executive functions. Score on subscale “Similarities” was
Rymaszewska1 , J.A. Beszłej1 , J. Samochowiec2 , M. Jabłoński2 , M.
10.30 ± 4.15 which is equivalent of average performance, and score
Wroński2 , A.A. Moustafa3 , B. Misiak4
on subscale “Calculating” was 6.8 ± 2.24 and indicates poor perfor- 1 Wroclaw Medical University, Psychiatry, Wroclaw, Poland; 2
mance. Insight score on SAIQ was insignificantly correlated with T
Pomeranian Medical University, Psychiatry, Szczecin, Poland; 3 Marcs
score on Wisconsin test (Pearson’s r = −0.243, p = 0.19 for the group
Institute of Brain and Behaviour, Western Sydney University Penrith,
with shorter duration of illness, and r = −0.030, p = 0.87 for the
School of Social Sciences and Psychology, Penrith, Australia; 4
group with longer duration of illness). Insight score was insignifi-
Wroclaw Medical University, Genetics, Wroclaw, Poland
cantly correlated with score on “similarities” (Mann–Whitney test, * Corresponding author.
p = 0.177), as well as score on “calculating” (Spearman’s rho = 0.059,
p = 0.65). Background and aims.– Prevalence of cigarette smoking is signif-
Conclusions.– No significant correlation of insight and executive icantly higher in patients with schizophrenia compared to the
functions were found. Further, longitudinal studies with larger general population. This clinical group is also characterized by
sample size are needed. robust cognitive impairments that can be detected already in the
Disclosure of interest.– The authors have not supplied a conflict of premorbid phase of illness. However, studies addressing the asso-
interest statement. ciation between cigarette smoking and cognition in patients with
psychosis have provided mixed findings. The aim of this study was
to assess the relationship between tobacco smoking and cognitive
E-PP1176 performance in patients with schizophrenia.
Treatment resistant schizophrenia: Methods.– 67 schizophrenic patients and 62 healthy controls were
the effect of polymorphic variants recruited. Cognitive performance was examined using the Repeat-
CYP2D6*4,*10 able Battery for the Assessment of Neuropsychological Status.
D. Sosin1* , D. Ivashchenko2 , D. Sychev3 , M. Ivanov1 Nicotine dependence was determined using the Fagerström Test
1 V.M. Bekhterev National Research Medical Centre for Psychiatry for Nicotine Dependence (FTND) and the pack-year index.
and Neurology, Department of Biology Psychiatry, Saint-Petersburg, Results.– Smokers with schizophrenia presented significantly lower
Russia; 2 Russian Medical Academy of Continuous Professional scores on immediate and delayed memory tests compared to
Education, Department of Personalized Medicine, Moscow, Russia; 3 non-smokers with schizophrenia after adjustment for potential
Russian Medical Academy of Continuous Professional Education, confounders. Smoking controls had significantly lower scores of
Department of Clinical Pharmacology, Moscow, Russia all cognitive domains, except for language skills compared to non-
* Corresponding author. smoking controls after adjustment for education level. There were
no significant correlations between FTND scores or pack-year index
Background and aims.– About One third of patients suffering and cognitive performance neither in the group of patients nor in.
from schizophrenia are considered treatment resistant. Whereas Conclusions.– Our results imply that cigarette smoking is related
CYP2D6 is only 2% of all cytochromes P450, it is involved in the to worse memory performance in schizophrenia and more robust
metabolism of about 20% of drugs and especially psychotropic cognitive deficits in controls.
drugs. There is evidence that certain variants of the CYP2D6 gene Disclosure of interest.– The authors have not supplied a conflict of
are responsible for poor tolerability of antipsychotic therapy. interest statement.
E-PP1178 Background and aims.– High risk of obstructive sleep apnea (OSA)
Asssociation of genetic polymorphism was reported in patients with schizophrenia. However, existing
of the drug metabolizing enzymes, screening questionnaires haven’t been validated in this population,
and the impact of comorbidity in this population has rarely been
dopamine and serotonin receptors in studied. The study was lead to show the prevalence and impact
schizophrenia patients undergoing of comorbid OSA in patients with schizophrenia and validate the
treatment with risperidone in North existing OSA screening scales.
Indian population Methods.– Patients with schizophrenia consecutively admitted
V. Subbiah1* , S. Maity2 , M. Munisamy2 , R. Sagar3 , U. to hospital (SCH, n = 51,18 F, age 37,7 ± 12,1) and patients with
Nayanabhirama4 schizophrenia and obesity (SCH/OBE, n = 31,16 F, age 38,6 ± 12,0)
1 All India Institute of Medical Sciences, Department of Biochemistry, were compared to healthy controls (n = 51,18 F, age 37,9 ± 11,0).
Rishikesh, India; 2 All India Institute of Medical Sciences, Berlin Questionnaire, Epworth Sleepiness scale, STOP-BANG ques-
Neurobiochemistry, New Delhi, India; 3 All India Institute of Medical tionnaire, NoSAS and No-Apnea scales were used to assess apnea
Sciences, Psychiatry, New Delhi, India; 4 Manipal College of risk. Severity of symptoms of schizophrenia was measured with
Pharmaceutical Sciences, Pharmacology, Manipal, India PANSS and Calgary scales and B-CATS tests. OSA was diagnosed
* Corresponding author. using Embletta system.
Results.– OSA (AHI≥5) was found in 21,6% of SCH group, in 45,2%
Background and aims.– Schizophrenia is a psychiatric disorder of SCH/OBE group and in 13,7% of healthy controls. Statistically
marked by severely impaired thinking, emotions and behaviors. significant differences in negative symptoms PANSS subscale, B-
Most drugs are efficacious on a small percentage (20-30%) of the CATS digit symbol test and daytime sleepiness were found between
population. Rispiridone is a atypical antipsychotic with selective patients with and without OSA. No existing screening scale showed
antagonistic properties at serotonin 5-HT2 and Dopamin D2 recep- satisfactory sensitivity and specificity. Neck circumference above
tors. Rispiridone is metabolized in the liver by cytochrome P450 41 cm (F) and 43 cm (M) with BMI>30 allowed to predict OSA in
isozymes predominantly catalyzed by CYP2D6. 76,8% of cases (PPV = 68,0%, NPV = 80,7%).
The study was undertaken to investigate the association between Conclusions.– OSA should be screened in patients with schizophre-
the genetic polymorphism of drug metabolizing enzymes, nia as it’s common, has negative influence on schizophrenia
dopamine receptors and serotonin receptors (HTR2A 102T/C, symptoms and may add up to higher mortality of these patients
HTR2C -759C/T, HTR2C 68G/C) in the Schizophrenia patients under The assessment of BMI and neck circumference proves satisfactory
Risperidone monotherapy treatment (Responders and Non respon- screening test in ambulatory conditions.
ders). Disclosure of interest.– The authors have not supplied a conflict of
Methods.– 80 unrelated chronic schizophrenia patients were interest statement.
enrolled in our study. Serum concentration of Risperidone was
measured using HPLC. PCR-RFLP technique was used for genotyp-
ing. E-PP1180
Results.– 11 SNPs (CYP2D6*3, CYP2D6*4, CYP2D6*10, CYP3A4*4, The THINC-integrated tool (THINC-it)
CYP3A4*5, DRD2TaqIA, TaqIB, DRD2 Ser311Cys, HTR2A 102T/C, for a brief measurement of changes in
HTR2C -759C/T and HTR2C 68G/C) showed allelic and genotypic
association with Risperidone non responders. Higher frequency
cognitive functioning and its
of Poor metabolizer (36%) was observed in (HTR2C 68G>C) correlation with the life quality of
–Risperidone non responder cases. Significant consistent rise in patients with schizophrenia
the genotypes of median drug levels between non responder and J. Szmyd* , P. Łukasiewicz, M. Walecka,
˛ K. Wojciechowska, A.
responder of Risperidone in schizophrenia patients were observed. Augustyn, M. Grochowski, M. Jarema, A. Wichniak
Mann-Whitney’s non-parametric test showed a significant differ- Institute of Psychiatry and Neurology, Third Department of
ence in Extensive metabolizers, Intermediate Metabolizers and Psychiatry, Warsaw, Poland
Poor metabolizers of drug levels between non responder, responder
groups of Risperidone.
Conclusions.– Our findings suggest that genetic polymorphisms in Background and aims.– Individuals suffering from schizophrenia
drug metabolizing enzymes together with dopamine and serotonin experience numerous cognitive deficits, which may be present dur-
receptors affects Resperidone metabolism and drug response. Iden- ing the period of remission and significantly hinder their daily
tification of Poor metabolizers and Intermediate Metabolizers in activities. Full neuropsychological assessment of the cognitive
anti -psychotic drug therapy is of potential clinical importance. functioning is a time-consuming process, hence it is often omit-
Disclosure of interest.– The authors have not supplied a conflict of ted altogether. The aim of this ongoing study is to validate the
interest statement. Polish version of THINC-it to assess the cognitive functioning and
comparing it with patients’ quality of life.
Methods.– So far twenty participants of a day clinic (females: 5;
E-PP1179 mean age:33,9 ± 10,5) were included in the study. WHOQOL-BREF
was used to measure the patients’ quality of life. THINC-it tool was
Obstructive sleep apnea in
used to assess their cognitive functioning. It consists of four tasks
schizophrenia - how to screen, why to which measure attention span, operational memory, and execu-
treat? tive functions and has been so far validated for detecting cognitive
K. Szaulińska1* , N. Kukla2 , K. Kołosowska2 , A. Rowicka2 , E. dysfunction in major depression.
Poradowska2 , A. Wichniak3 Results.– Patients suffering from schizophrenia achieved lower
1 Institute of Psychiatry and Neurology, Department of Prevention
scores than the general population. Longer reaction times and
and Treatment of Addictions, Warsaw, Poland; 2 Institute of lower scores were observed in every domain among the test group.
Psychiatry and Neurology, Third Department of Psychiatry, Warsaw, N-back type task and symbol substitution test posed the most
Poland; 3 Institute of Psychiatry and Neurology, Third Department of challenge for the patients. The general quality life score was also
Psychiatry, Department of Clinical Neurophysiology- Sleep Medicine relatively low and related to cognitive functioning. Importantly,
Center, Warsaw, Poland repeated measurements were required due to the observed large
learning effect.
Conclusions.– Initial analysis supports the overall consensus of the of the disease and are now properly conceptualized as early
current research - cognitive impairment in schizophrenia is the endo-phenotypes of schizophrenia. Despite the significant role
core of the disorder and is related to overall quality of life. It sug- of psycho-motor disturbances in schizophrenia, very few studies
gests also that a one-time measurement did not provide a reliable have investigated locomotor pattern of gait in schizophrenia. The
assessment of patients’ cognitive functioning. present study aimed to detect the presence of gait disturbances and
Disclosure of interest.– The authors have not supplied a conflict of postural anomalies by means of “Gait Analysis System”, in order
interest statement. to identify specific underlying endophenotipic deficits in motor
control.
Methods.– 21 patients and 14 healthy subjects have been analyzed
E-Poster Presentation: Schizophrenia and other psychotic disorders in gait and postural sway by classic full Gait Analysis system.
- Part XI Results.– Schizophrenic patients showed longer gait cycle com-
E-PP1181 pared to controls, with significative difference. Moreover,
Effect of lurasidone on cognition in schizophrenic group had greater sway area with open eyes, and this
adolescents with schizophrenia: difference was significant too. Finally, patients had more postural
stability following the removal of visual input, as demonstrated by
analysis of a 2-year open-label
more length of the curve, with no significative differences in the
extension study sway area, compared to controls.
P.D. Harvey1 , R. Goldman2 , M. Tocco2* , L. Deng2 , J. Cucchiaro2 , A. Conclusions.– According with previous studies, schizophrenic
Loebel2 patients show a different locomotor pattern and specific postural
1 University of Miami Miller School of Medicine, Psychiatry and
sway abnormalities compared to controls. Particularly, the present
Behavioral Sciences, Miami, USA; 2 Sunovion Pharmaceuticals Inc., study show a “motor paradox” in the control of posture and balance
Medical Affairs, Marlborough, USA in schizophrenia: notably, patients exhibit more postural instabil-
ity with open eyes, as due to an interference of visual input; with
Background and aims.– To evaluate the short and long-term postural stabilization following the removal of visual input. The
effects of lurasidone on cognitive performance in adolescents with present findings would support the hypothesis of a disruption in
schizophrenia. multi-sensory integration, as a core feature of schizotaxic vulnera-
Methods.– Patients ages 13–17 with schizophrenia who com- bility, associated to subtle deficits in basic motor control of postural
pleted 6 weeks of double-blind (DB) fixed-dose treatment with stability.
lurasidone were eligible to enroll in a 2-year, open-label (OL), Disclosure of interest.– The authors have not supplied a conflict of
flexible-dose (18.5–74 mg/d) extension study. Cognitive function interest statement.
was assessed with the Brief CogState battery, which evaluates 4
cognitive domains: psychomotor speed, attention, visual learning,
E-PP1183
and working memory. Based on normative data, Z-scores were cal-
culated for each of the 4 cognitive domains, and for an overall Specific relationships exist between
composite score. insight and cognition in schizophrenia
Results.– After 6 weeks of DB treatment, mean change in cognitive I. Torio* , D. Rentero, M. Caballero, E.M. Sanchez-Morla, M.
composite Z-score was -0.09, +0.11, and −0.10 for lurasidone 40 mg Dompablo, R. Rodriguez-Jimenez
and 80 mg, and placebo, respectively. A total of 271 patients com- Instituto de Investigación Hospital 12 de Octubre imas12,
pleted 6 weeks of DB treatment and entered the 2-year OL study. Department of Psychiatry, Madrid, Spain
The sample sizes with Cogstate data available at each assessment
time-point were: OL-baseline (n = 267), week 28 (n = 206), week 52
(n = 182), Week 76 (n = 167), and week 104 (n = 147). Mean change Background and aims.– Cognition has been proposed as a deter-
in Z-score, from DB baseline to OL weeks 0 (OL-baseline), 28, 52, minant of insight in schizophrenia, but results have been mixed.
76, and 104, respectively, were observed for the cognitive compos- The MATRICS Consensus Cognitive Battery (MCCB) was devel-
ite (+0.04, +0.16, +0.18, +0.03, +0.06), and for the CogState domains oped to provide a cognitive assessment tool to help overcome
psychomotor speed (−0.08, −0.01, −0.05, −0.35, −0.39), attention the heterogeneity of existing instruments (Nuechterlein et al.,
(−0.00, −0.01, −0.08, −0.29, −0.44), visual learning (+0.19, +0.46, 2008; Rodriguez-Jimenez et al., 2012; Rodriguez-Jimenez et al.,
+0.64, +0.70, +0.93), and working memory (+0.18, +0.25, +0.59, 2015). The aim of the present study was to study the relationship
+0.52, +0.48). between cognitive domains and insight in a sample of patients with
Conclusions.– Over the course of this 2-year study of adolescents schizophrenia.
with schizophrenia, treatment with lurasidone was not associated Methods.– A cross-sectional study was conducted in a sample of
with deleterious effects on overall cognitive function. 103 patients (31.1% female). The mean age was 41.5 years (SD
Disclosure of interest.– The authors have not supplied a conflict of 8.5). Cognition was measured with the MCCB, and insight with the
interest statement. three general ítems of the SUMD (awareness of mental disorder,
awareness of need for treatment, and of social consequences of the
disorder), and the total awareness and attribution items (Amador
E-PP1182 & Strauss 1990). Pearson correlation coefficients were calculated.
Results.– Awareness of having a mental disorder showed a sig-
“The motor paradox”: a study of
nificant correlation with processing speed (−0.257; p = .009) and
postural sway in schizophrenia working memory (−0.257; p = .005). Awareness of need for treat-
M. Tonna1* , F. Paraboschi1 , F. Marsella1 , V. Lucarini1 , L. Galuppo2 , ment and total awareness showed no significant relationships
G. Gobbi2 , C. Marchesi1 , M. Vitale2 with cognition. Working memory showed a significant correlation
1 Psychiatry Unit, Neuroscience, Parma, Italy; 2 Biomedical,
with awareness of consequences (−0.266; p = .007), and with total
Biotechnological and Tranlational Sciences S. Bi. Bi. T., Medicine and attribution (−0.216; p = .028). Processing speed (−0.263; p = .007),
Surgery DiMeC, Parma, Italy attention (−0.240; p = .015), and visual learning (−0.282; p = .004)
showed relationship with awareness of social consequences.
Background and aims.– Subtle motor abnormalities have been Conclusions.– Insight is a multidimensional construct holding spe-
identified in schizophrenic patients since the first descriptions cific associations with different cognitive domains, such as working
memory, attention, and processing speed. Further studies are
required to understand the complex linkages between cognition Background and aims.– Shared decision making denotes a struc-
and insight, while the study of individual relationships seem nec- tured process that encourages full participation by patient and
essary. provider in making complex medical decisions. There has been
Disclosure of interest.– The authors have not supplied a conflict of extensive and growing interest in its application to long-term
interest statement. illnesses. The great majority of schizophrenics can understand
treatment choices and making rational decisions. Although the
main justification for shared decision-making is ethical, several
E-PP1184 randomized controlled trials support its effectiveness in improving
Preliminary data of validation in a the quality of decisions.
rating scale of observable social To demonstrate the effectiveness, measured as treatment adher-
ence and readmissions at 12 months, of shared decision making in
cognition (OSCARS) in spanish
the choice of antipsychotic treatment at discharge in a sample of
population with schizophrenia schizophrenics hospitalized after an acute episode of their disorder.
disorder To present results of the complete sample and a regression model
R. Torrecilla1* , A. López-Martín2 , J. Pérez Revuelta2 , E. García for adherence.
Spínola2 , F. González Saiz3 , J.M. Villagrán Moreno4 Methods.– Randomized controlled trial, prospective, two parallel
1 FEA-Psiquiatría-USMC Villamartín UGC-SM Norte de Cádiz, Jerez de
groups, simple blind, comparing two interventions (shared deci-
la Frontera Hospital, Chiclana de la Frontera, Spain; 2 Instituto de sion making and treatment as usual). Study population: Inpatients
Investigación e Innovación en Ciencias Biomédicas de Cádiz – diagnosed of schizophrenia and schizoaffective disorders (ICD-
INiBICA. Universidad de Cádiz, Consejería de Salud de la Junta de 10/DSM-IV-R: F20 y F25) [120].
Andalucía, Neuroscience, Cádiz, Spain; 3 FEA-Psiquiatría-USMC Jérez Results.– After 12 months follow-up, there are statistically sig-
UGC-SM Norte de Cádiz, Neuroscience. University of Cádiz, Cádiz, nificant differences for several variables when we try to explain
Spain; 4 Coordinador de la Unidad de Salud Mental Hospitalaria, antipsychotic treatment adherence. Attitude towards treatment,
Unidad de Gestión Clínica de Salud Mental, Área de Gestión Sanitaria therapeutic alliance, confidence in decision and insight can explain
Norte de Cádiz, Hospital de Jerez de la Frontera, Servicio Andaluz de a 50% of adherence differences (R2 = 0,5 p < 0.001). We are present-
Salud, Cádiz, Spain ing a structural equation model designed with these results.
Conclusions.– The few empirical studies on this topic, show that
SDM encourages better communication and greater patient satis-
Background and aims.– Individiuals with schizophrenia show
faction. The final aim of the study is to assist the implementation of a
deficits in social cognition. Evaluating this aspect is important to
new model of interaction physician – patient in our health services
plan more effective interventions. Assessing through the observ-
and shows its indirect implications in treatment adherence.
able social cognition perceived by the main caregiver is a measure
that provides new information on this aspect. The objective is ana-
interest statement.
lyzing psychometric parameters of validity and reliability of the
OSCARS scale in Spanish population.
Methods.– Observational cross-sectional study with 73 patients E-PP1186
of Community Mental Health Unit North of Cádiz (Spain); 30%
Vitamin D deficiency associated with
females; SD = 0.5, with a mean age 46.6 (SD = 13.9), mean years of
education was 11.3 (SD = 5.3) to assess performance in domains of cognitive functioning in
Social Cognition with Observable by means of Social “Cognition – schizophrenia
A Rating Scale” (OSCARS) R. Trabelsi* , H. Ben Ammar, A. Aissa, A. khalifa, Z. El Hechmi
Results.– Cronbach’s alpha coefficient was 0.8, suggesting a high Razi Hospital, Psychiatry F, La Manouba, Tunisia
degree of internal consistency for the OSCARS.
Conclusions.– The OSCAR scale obtains an acceptable reliability
coefficient. Nevertheless, it is convenient to expand the sample Background and aims.– Cognitive dysfunctions are core features
size and study the validity of the construction and carry out other of schizophrenia with substantial impact on daily functioning.
reliability tests. Vitamin D deficiency has been found to be related to cognitive dys-
Disclosure of interest.– The authors have not supplied a conflict of functions, but the associations between vitamin D deficiency and
interest statement. cognition in schizophrenia are largely unknown.
Methods.– This cross-sectional study was conducted in 67 patients
with schizophrenia according to the DSM-V recruited during the
E-PP1185 year 2015, in which we measured the blood level of vitamin D. The
population of patients was evaluated by a clinical protocol and a
Decide study: proposal of adherence
battery of cognitive tests.
model in schizophrenia. A multiple Results.– Vitamin D deficiency was related to auditory-verbal mem-
regression analysis ory impairment as assessed by the direct digit span test score
R. Torrecilla1* , J. Pérez Revuelta2 , Á. López-Martín2 , J.M. Villagrán (p = 0.002, r = 0.34). Vitamin D deficiency was significantly asso-
Moreno3 , F. González Saiz4 ciated with alteration of the executive functions at several levels
1 FEA-Psiquiatría-USMC Villamartín UGC-SM Norte de Cádiz, Jerez de
(p < 0.05): the ability to inhibit automatic processes, ideomotor
la Frontera Hospital, Chiclana de la Frontera, Spain; 2 Instituto de speed, treatment speed, as well as mental flexibility and research
Investigación e Innovación en Ciencias Biomédicas de Cádiz – initiation strategies. Hyovitaminosis D was associated too with
INiBICA, Universidad de Cádiz, Consejería de Salud de la Junta de attention deficit, selective attention, and visuospatial working
Andalucía, Neuroscience, Cádiz, Spain; 3 Psiquiatra, Coordinador de memory difficulties, as demonstrated by positive correlations of
la Unidad de Salud Mental Hospitalaria, Unidad de Gestión Clínica de vitamin D level with patient performance in both trials of the ZAZZO
Salud Mental, Área de Gestión Sanitaria Norte de Cádiz, Hospital de test, R1 (p = 0.043, r = −0.248) and R2 (p = 0.022, r = 0.280).
Jerez de la Frontera, Servicio Andaluz de Salud, Cádiz, Spain; 4 Conclusions.– The associations between vitamin D deficiency and
FEA-Psiquiatría-USMC Jerez UGC-SM Norte de Cádiz, Neuroscience. cognitive impairment are arguments for planning large-scale ran-
University of Cádiz, Cádiz, Spain domized controlled trials in target populations to draw conclusions
about the potential effect of vitamin D supplementation on cogni-
tion in schizophrenia.
Disclosure of interest.– The authors have not supplied a conflict of Results.– 188 patients admitted to hospital between 2014 and
interest statement. 2017 were included, with a mean age of 23 years. Mean
plasma levels of folates, vitamin B12 and homocysteine were
12,86 nmol/L, 309,3 pmol/L and 12,59 ␮mol/L, respectively. In over
E-PP1187 a third of patients (35,5%), at least one abnormality of one-carbon
The relation between metabolic metabolism was found. The prevalence of plasma folate deficiency
syndrome parameters and cognitive was high, found to be around 20,7%.
Conclusions.– The frequency of one-carbon metabolism anoma-
functions in schizophrenia lies in young patients with psychotic disorders is relatively high.
S. Tunc
This result spotlights the desirability of new therapeutic prospects
Kafkas University, Department of Psychiatry, Kars, Turkey
* Corresponding author. such as folate supplementation, in view of personalized medical
approaches to psychotic symptoms.
Background and aims.– Schizophrenia patients are known to have Disclosure of interest.– The authors have not supplied a conflict of
a higher rate of medical problems such as obesity, hypertension, interest statement.
and diabetes mellitus (DM). It is unclear if there is an association
between cardio-metabolic risk factors and cognitive functions as
E-PP1189
well as the extent to which specific areas of cognitive functions are
specifically affected. This study aimed to investigate the association The speed of information processing
between metabolic syndrome parameters and cognitive functions as a possible endophenotypic marker
in schizophrenia patients. in schizophrenia
Methods.– Forty-four schizophrenia patients in remission and I. Veleva1* , M. Stoimenova-Popova1 , P. Chumpalova1 , L. Tumbev1 ,
forty-five healthy volunteers were included in this comparative R. Iakimova2 , M. Stoianova2
case-control study. Stroop Test, Digit Symbol Substitution Test, 1 Medical University, Psychiatry and Medical Psychology, Pleven,
Trail Making Test Part A and B, and Reaction Time Test were applied Bulgaria; 2 Medical University, Psychiatry and Medical Psychology,
to the participants. Levels of triglyceride, high-density lipoprotein Sofia, Bulgaria
(HDL), fasting blood glucose (FBG) and measurements of waist cir- * Corresponding author.
cumference, blood pressure, body mass index (BMI) were obtained.
Results.– In this study, no significant difference was found between Background and aims.–
the groups regarding age and gender. The frequency of obesity was Introduction.– Cognitive endophenotyping is a modern approach to
significantly higher in the schizophrenia group than in the control studying the genetic risk of schizophrenia.
group. HDL level in control group; waist circumference, BMI, and The purpose of this study is to investigate the speed of information
FBG levels were significantly higher in the schizophrenia group. The processing in patients with paranoid schizophrenia (PS) and first
incidence of metabolic syndrome in schizophrenia group was sig- generation relatives (FGR) using the Digit symbol substitution test
nificantly higher than the control group. All cognitive test results (DSST), to report and compare their results with those of healthy
were significantly worse in schizophrenia patients than in the con- controls.
trol group. Methods.– The study was conducted with 108 PS (66 men and 42
Conclusions.– The findings of this study suggest that metabolic women with mean age 38.86 ± 10.02) with disease duration of
syndrome parameters are a risk factor for various medical condi- 12.68 ± 8.2 years with mean disease severity according to PANSS
tions, as well as a decrease in cognitive function in schizophrenia 71, 8 ± 5.1 and 58 FGR (30 men and 28 women m.a. 36.71 ± 11.74)
patients. Metabolic syndrome parameters are more likely to occur and 60 HC (37 men and 23 women m.a. 35.68 ± 11.36) via DSST.
in schizophrenia patients with cognitive impairment. The results were reached at statistical significance of p < 0.05.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The test success rate for PS was 33.92 item. FGR 44.74,
interest statement. S-44.74. PS differ from FGR and HC significantly in all indicators
(p = 0.0001). FGR and HC are only distinguished by the number of
errors in the test (p = 0.0001). Age, educational status, symptom
E-PP1188 severity (measured by PANSS), duration of the disease all have
Abnormalities of one-carbon effect on the results, but not gender and type of therapy used.
metabolism in a cohort of patients Conclusions.– The delay in information processing speed with DSST
aged 15 to 30 years with psychotic was mild in FGR and more pronounced in PS. This is associated with
reduced inhibitory control and/or memory impairment. This makes
disorders it a suitable monofenotype marker for schizophrenia.
M. Urban* , F. Rivollier, M.O. Krebs
Hôpital Sainte-Anne, Service hospitalo-universitaire, Paris, France
Background and aims.– Folates, main actors in one-carbon

E-PP1190
metabolism, are involved in the synthesis of monoamines and
maintain genomic stability. According to a gene-environnement Risk factors for violence in persons
interaction model, an association between folate deficiency and with and without psychosis in the
schizophrenia seems to exist. The main purpose of this study was to czech republic: risk and protective
assess the prevalence of plasma folate or vitamine B12 deficiency factors
and hyperhomocysteinemia in young patients with psychotic dis- J. Vevera1* , S. Hodgins2 , Č. Martin3
orders. 1 First Faculty of Medicine, Charles University, Psychiatry, Prague 2,
Methods.– This epidemiological cohort study was monocentric, Czech Republic; 2 Institut Universitaire en Santé Mentale de
observational, analytical and retrospective. It was conducted at the Montréal, Département de Psychiatrie, Université de Montréal,
Service Hospitalo-Universitaire of the Centre Hospitalier Sainte- Montréal, Canada; 3 Teaching Hospital- Královské Vinohrady,
Anne in Paris. The inclusion criteria were being between 15 and Department of Psychiatry-, Prague, Czech Republic
30 years old and having a diagnosis of first-episode psychosis, * Corresponding author.
schizophrenia, schizoaffective disorder or persistent delusional dis-
order.
Background and aims.– To prevent violence among persons with (16%). The majority of the sample (88%) has not been hospitalized
psychosis, further knowledge of the correlates and risk factors is in the last 12 months and 47% patients have not been hospitalized
needed. in the last 10 years.
Methods.– This study examined factors associated with violent Conclusions.– This study allowed a demographic and clinical assess-
assaults in 158 patients with psychosis and in a matched control ment of outpatients attending a community psychiatric clinic,
sample of 158 adults without psychosis. Participants completed which can contribute to a deeper understanding of patients’ needs
interviews and questionnaires to confirm diagnoses, report on and to improve community-based interventions in the future.
aggressive behavior and current and past victimization, and sub- Disclosure of interest.– The authors have not supplied a conflict of
stance use. Additional information was collected from collateral interest statement.
informants and clinical files. Multiple regression analyses were
conducted to identify factors that were independently associated
with committing an assault in past 6 months. E-PP1192
Results.– The presence of a psychotic disorder was associated with Neurophysiological correlates of
an increased risk of assaults (OR = 3.80; 95% CI 2.060–7.014). Addi- negative symptom domains: an
tional risk factors in persons with and without psychosis included
auditory oddball study in
recent physical victimization (OR = 7.09; 95% CI 3.922–12.819),
childhood maltreatment (OR = 3.15; 95% CI 1.877–5.271), the level schizophrenia
of drug use (OR = 1.13; 95% CI 1.063–1.197), and the level of alcohol A. Vignapiano1* , A. Mucci1 , G.M. Giordano1 , G. Di Lorenzo2 , F.
use (OR = 1.04; 95% CI 1.000–1.084). Increasing age (OR = 0.96; 95% Ferrentino2 , M. Altamura3 , A. Bellomo3 , S. Galderisi1
1 University of Campania “Luigi Vanvitelli”, of Psychiatry, Naples,
CI 0.942–0.978) and employment (OR = 0.30; 95% CI 0.166–0.540)
were protective factors. Except for drug use, which appeared to Italy; 2 University of Rome “Tor Vergata”, of Systems Medicine, Rome,
have greater effect on violence in the group without psychosis, Italy; 3 University of Foggia, of Clinical and Experimental Medicine,
there were no major differences between patients and controls in Psychiatry Unit, Foggia, Italy
these risk and protective factors. To our knowledge, this is the first
published comparison of assault predictors between schizophrenia Background and aims.– Negative symptoms have long been recog-
patients and matched controls. nized as a heterogeneous psychopathological dimension, with a
Conclusions.– Recent physical victimization was the strongest pre- strong negative impact on real-life functioning.
dictor of assaults. Our findings are consistent with the emerging Five main constructs are included in the negative symptom dimen-
empirical evidence pointing to the very important role of victim- sion: anhedonia, asociality, avolition, blunted affect and alogia.
ization in eliciting violent behavior by the victims. Factorial analyses studies revealed that these constructs cluster
Disclosure of interest.– The authors have not supplied a conflict of in two separate domains: avolition-apathy (AA; including avoli-
interest statement. tion, asociality and anhedonia) and expressive deficit (ED; including
alogia and blunted affect), which are linked to different neurobio-
logical aberrations and outcome indices.
E-PP1191
Few studies investigated the neurobiological bases of negative
Demographic and clinical symptom domains, using event-related potentials (ERPs), but find-
characteristics of outpatients ings were controversial.
attending community mental health The aim of our study was to evaluate, in the context of the multi-
treatment center study of the Italian Network for Research on Psychoses, the
V. Rocha, S. Fonseca, M. Vieira-Coelho* , C. Guerra, C. Santos, A. relationships between N100 and AA and ED domains in subjects
Cortiñas, J. Morais, R. Guedes, A. Machado, A. Delgado, E. Pereira, F. with schizophrenia (SCZ).
Coutinho, J. Rebelo, V. Covelo, F. Andrade, S. Pinto, M. Viana, R. Methods.– During an auditory odd-ball task, ERPs were recorded in
Curral 115 chronic stabilized SCZ and 64 healthy controls (HC). Negative
Centro Hospitalar de São João, Psiquiatria e Saúde Mental, Porto, symptom domains were assessed with BNSS. Multiple stepwise lin-
Portugal ear regressions were used to establish the variables that predicted
* Corresponding author. N100 amplitude for standard and target stimuli. As independent
variables, depression, parkinsonism, positive and disorganization
Background and aims.– The community approach to mental health dimensions, neurocognitive composite score, AA and ED domains,
treatment is usually based on recovery, assertive treatment in the were included in the model.
community, and promoting patients’ autonomy and social integra- Results.– We found a significant N100 amplitude reduction in SCZ
tion. The Community Psychiatry Unit of Centro Hospitalar de São compared with HC. Regression models revealed that N100 ampli-
João (Portugal) follows this approach in order to minimize rehos- tude for standard (b = 0.287, p = 0.004)and target stimuli (b = 0.290,
pitalizations and institutionalization. p = 0.005) were predicted by ED.
To characterize the active population attending community psy- Conclusions.– Our findings revealed a specific pattern of association
chiatric clinic at Centro Hospitalar de São João regarding their between ED and N100 aberrations, suggesting that specific negative
demographic and clinical profile, and service use variables (e.g., symptoms could be associated with early processing deficits in SCZ.
number of hospitalizations). Disclosure of interest.– The authors have not supplied a conflict of
Methods.– A questionnaire was administered to 311 outpatients interest statement.
over a 12 month period (January to December 2017).
Results.– Of the 311 participants, 56% were men and 54% were diag-
nosed with schizophrenia. The mean age was 49.79 (SD = 11.77).
Most patients were single (65%), did not live alone (81%), and were
not professionally active (83%). Long-acting injection antipsychotic
was prescribed to 51% participants, of which typical antipsychotics
(mainly Haloperidol) were prescribed to 69% participants and atyp-
ical antipsychotics (mainly Risperidone and Paliperidone) were
prescribed to 31% participants. The most common comorbidities
were dyslipidemia (19%), arterial hypertension (17%), and obesity
E-PP1193 the Mini International Neuropsychiatric Interview (MINI) using the

The relationship between depressive ICD-10 research diagnostic criteria. The assessments included Posi-
symptoms, smoking and disease tive and Negative Syndrome Scale, objective and subjective Clinical
Global Impression, Liebowitz Social Anxiety Scale, Beck Depression
severity in patients with Inventory-second edition, Internalized Stigma of Mental Illness,
schizophrenia the Temperament and Character Inventory, and Adult Dispositional
S. Vlatkovic1* , Z. Madzarac2 , L. Tudor3 , M. Sagud4 , A. Mihaljevic Hope Scale.
Peles4 , D. Svob Strac3 , N. Pivac3 Results.– The individual rate of suicidality (suicidal index from
1 Clinics for Psychiatry Vrapce, Psychiatry, Zagreb, Croatia; 2
MINI) strongly positively correlated with self-stigma, level of
University Hospital Centre Zagreb, Psychiatry, Zagreb, Croatia; 3 depression, social anxiety, and harm-avoidance, and negatively
Rudjer Boskovic Institute, Division of Molecular Medicine, Zagreb, correlated with hope, self-directedness, and stigma resistance.
Croatia; 4 School of Medicine, University of Zagreb, Psychiatry, Conclusions.– Individuals with additional symptoms of depression,
Zagreb, Croatia social anxiety, trait-like anxiety, and self-stigma should be carefully
monitored for suicidal ideation. On the opposite side, patients with
sufficient hope, self-esteem, and goal-directed attitudes are less
Background and aims.– Patients with schizophrenia have high
likely to have suicidal thoughts and may potentially be role mod-
prevalence of both depression and cigarette smoking. However, no
els in group rehabilitation programs, motivating more distressed
study has simultaneously compared the severity of schizophrenia,
colleagues and showing them ways to cope.
depressive symptoms, treatment-resistance and nicotine depen-
dence.
interest statement.
The aim of this study was to determine clinical variables associated
with the severity of depression in patients with schizophrenia.
Methods.– This cross-sectional study was carried out in patients E-PP1195
with schizophrenia, who were not taking antidepressants. The
Fagerstrom Test for Nicotine Dependence (FTND) was used to
The role of regenerative factors in the
assess tobacco dependence, Calgary Depression Rating Scale for etiopathogenesis of first episode
Schizophrenia (CDSS) to measure depression, and the Positive psychosis and patient functioning
and Negative Syndrome Scale (PANSS) to evaluate symptoms K. Waszczuk1* , J. Kucharska-Mazur1 , J. Samochowiec1 , M.
of schizophrenia. Treatment-resistant schizophrenia (TRS) was Jabłoński1 , M. Ratajczak2 , B. Dołegowska
˛ 3 , M. Tarnowski4
1 Pomeranian Medical University, Department of Psychiatry,
defined as a failure of at least two adequate antipsychotic trials.
Results.– Overall 340 patients were included (median age 45 years, Szczecin, Poland; 2 University of Louisville, Stem Cell Institute at
204 smokers, 300 males and 125 with TRS). The CDSS total score James Graham Brown Cancer Center, Louisville, USA; 3 Pomeranian
was positively correlated with the PANSS total score ( = 0.555; Medical University, Department of Microbiology, Immunology and
p < 0.001), chlorpromazine equivalents ( = 0.197; p = 0.011) and Laboratory Medicine, Szczecin, Poland; 4 Pomeranian Medical
age ( = 0.144; p = 0.008). Patients with TRS had higher PANSS total University, Department of Physiology, Szczecin, Poland
score and all its subscales but also higher CDSS score (p < 0.001).
The CDSS was similar between smokers and non-smokers, and not
related to FTND score. Background and aims.– In recent years, more and more attention
Conclusions.– While the severity of depression was not related has been devoted to the search for biological markers of psychotic
to smoking status and nicotine dependence, it was correlated disorders. The role of regenerative factors seems to be a promising
with the intensity of psychotic symptoms and antipsychotic dose. direction for further research. The aim of this study was to evalu-
Depression in our sample might be induced by more pronounced ate the effects of stem cell mobilization and factors affecting their
psychopathology or higher doses of antipsychotics, but not by mobilization on symptom severity and functioning of patients with
smoking. first episode psychosis (FEP).
Disclosure of interest.– The authors have not supplied a conflict of Methods.– The study included 30 persons diagnosed with FEP,
interest statement. divided into two subgroups: “schizophrenic” (F20, F23.1 and F23.2)
and “non-schizophrenic” (other diagnoses according to ICD-10).
Symptom severity was assessed with the PANSS. The patients had
E-PP1194 their blood drawn twice for laboratory tests: before neuroleptic
treatment and after clinical improvement and PANSS score reduc-
Suicidality, self-stigma, social anxiety
tion of at least 20%.
and personality traits in stabilized Results.– VSEL stem cell mobilization into peripheral blood was
schizophrenia patients – a observed in the investigated sample. Inverse correlations were
cross-sectional study found between the PANSS scale and subscale scores and the number
K. Vrbova1* , J. Prasko1 , M. Ociskova1 , M. Holubova2 , K. Kantor1 , A. of HSCs Lin-/CD45+/CD34+, as well as an increased HSC mobi-
Kolek1 , A. Grambal1 , M. Slepecky3 lization after neuroleptic treatment. Significant correlations were
1 Faculty of Medicine and Dentistry- Palacky University, Department observed in the “schizophrenic” group after treatment with neu-
of Psychiatry, Olomouc, Czech Republic; 2 Hospital Liberec, roleptics: higher P score was directly correlated with the level of
Department of Psychiatry, Liberec, Czech Republic; 3 Department of the complement component C3a, while the G score was inversely
Psychology Sciences, Faculty of Social Science and Health Care, correlated with the serum concentration of S1P.
Constantine the Philosopher University, Nitra, Slovak Republic Conclusions.– These findings confirm the role of stem cells and
* Corresponding author. factors affecting their mobilization in FEP. This subject, however,
requires further research on a larger group of patients.
Background and aims.– Patients who have schizophrenia are more Disclosure of interest.– The authors have not supplied a conflict of
prone to suicidal behavior than the general population. Suicidal interest statement.
attempts are fatal in 20%–40%. This study aimed to find connections
between suicidality and self-stigma, hope, and personality traits in
patients with schizophrenia.
Methods.– Forty-eight stabilized outpatients with schizophrenia
attended this cross-sectional study. Patients were diagnosed by
E-PP1196 Results.– Ms L, a 25-year-old Chinese lady staying with her mother

Inflammation markers and and brother, was brought to our hospital by her family, upon police
kynurenine pathway metabolites in recommendation for psychiatric assessment. Ms L gave an account
that she was sexually assaulted multiple times 10 years ago and
major psychiatric disorders - pilot that the men responsible were still following her and her fam-
study ily. She reported to police on several occasions, but police did not
M. Wiedlocha1* , P. Marcinowicz1 , T. Koweszko1 , A. Zalewska2 , M. investigate. She and her family believed that the gangsters who had
Maciejczyk3 , N. Waszkiewicz4 , A. Szulc1 assaulted her continued to persecute them.
1 Clinic of Psychiatry, Department of Health Sciences, Medical
Conclusions.– The patient ingrained her beliefs into her family, caus-
University of Warsaw, Pruszkow, Poland; 2 Medical University of ing a considerable disruption in their lives. The shared delusional
Bialystok, Department of Restorative Dentistry, Bialystok, Poland; 3 symptoms in a family can be considered as the family’s attempt to
Medical University of Bialystok, Department of Physiology, Bialystok, maintain cohesiveness in the presence of a perceived hostile envi-
Poland; 4 Medical University of Bialystok, Department of Psychiatry, ronment. The lack of insight of the patient as well as her family
Choroszcz, Poland increased the complexity of the case. We recommend a multidisci-
plinary team approach to manage folie a famille.
Background and aims.– Kinurenine metabolites influence the course
interest statement.
of various psychiatric disorders. 95% of circulating tryptophan
(Trp) is metabolized into N-formyl-kinurenine (N-formylKyn) and
after deformylation to kynurenine (Kyn). Kyn is the substrate for E-PP1198
two antagonistic pathways, one of which results in formation od
kinurenic acid (KYNA). KYNA is the only known endogenous com-
The change in perception of depot/LAI
pound with NMDA antagonistic activity and is a molecule proposed antipsychotic treatment according to
responsible for psychotic symptoms and cognitive deterioration. view of Slovak psychiatrists.
Several studies have demonstrated that inflammatory cytokines Comparison 2015/2018
increase Trp-Kyn transformation. M. Zelman
Methods.– 63 patients admitted to Mazovian Specialized Health Psychiatric hospital Hronovce, Psychiatric hospital Hronovce,
Centre in Pruszkow, Poland were examined with the use of Brief Hronovce, Slovak Republic
Psychiatric Rating Scale. Their blood serum was tested for inter- * Corresponding author.
leukins (IL-1, IL-6), Trp, Kyn and N-formylKyn levels.
Results.– The study group consisted of addicts (N = 13), patients with Background and aims.– The time of availability of second-generation
psychosis (N = 18), mood (N = 20) and anxiety disorders (N = 12). depot/LAI antipsychotics and increasing empirical experience, are
Correlation analysis showed significant results only in the group influencing the psychiatrists view of position of this medication
of psychotic patients: between IL-6 and Kyn (RSpearman = 0,562, form in the therapy of schizophrenia.
p = 0,004), and between IL-6 and N-formylKyn (RSpearman = 0,660, Methods.– We focused on finding the differences in opinion of
p = 0,007). Psychotic patients also showed a negative correlation Slovak psychiatrists on the use of this cure in some specific situ-
between Trp/Kyn ratio and IL-6 (RSpearman = −0,648, p = 0,012); ations in the therapy of schizophrenia. We realized our research
and also between Trp/N-formylKyn ratio and Il-6 (RSpear- via questionnaire presented to psychiatrists in June 2015 (n = 47)
man = −0,652, p = 0,011). There were no significant correlations and subsequently in June 2018 (n = 43).
with regard to other diagnosis groups. Results.– In 2018, depot/LAI medication was preferred by psychi-
Conclusions.– Our study confirmed the previously observed rela- atrists (in more than 85% of cases) when low compliance, poor
tions between IL-6 and kynurenine metabolites. What is more, insight or frequent episodes. Relatively lower impact on the choice
this relation was strong but present only in psychotic patients and of medication was proved by the type of symptoms (positive, neg-
totally absent in the case of other subjects. The correlations were ative). Depot/LAI antipsychotic therapy is, according to opinion of
even stronger in the case of patients with current hallucinations. psychiatrists, not suitable in first episode of schizophrenia (74% of
Regardless of the qualitative value of these results their interpre- respondents). In the terms of tendencies to indicate depot antipsy-
tation requires some caution and further studies on more robust chotics, second-generation antipsychotics were preferred in the
patient groups. cases of adverse events (85%), negative symptomatology (81%) and
Disclosure of interest.– The authors have not supplied a conflict of short lasting of psychotic disorder (67%). We didn’t find the prefer-
interest statement. ence of the first-generation antipsychotics in any specific therapy
situation. Within the comparison of opinion on the indication of
depot/LAI medication between the years 2015-2018, the most sig-
E-PP1197 nificant change was found in preferences in young patients and in
A case study of folie a famille economically active people.
J. Ying* , P.R. Po Conclusions.– Very significant move happened in decision-making
Institute of Mental Health, General Psychiatry, Singapore, Singapore between the types of depot antipsychotics. In every explored
* Corresponding author. situation, the second-generation agent was preferred, the most
significantly in the indication in chronic forms of schizophrenia
Background and aims.– Shared psychotic disorder has been vari- (increase from 22% in 2015 to 59% in 2018).
ously called as folie a deux, folie a trois, folie a famille, psychosis of Disclosure of interest.– The authors have not supplied a conflict of
association, communicated insanity and shared paranoid disorder. interest statement.
Shared psychotic disorder is rare, and it’s even rarer when involv-
ing the entire family. To our knowledge, this is the first case report
of folie a famille in Singapore.
This study aimed to describe a case of folie a famille in Singapore
and raise awareness of complexities in management.
Methods.– This is a case report. Information was gathered based on
medical records.
E-PP1199 Background and aims.– The study of self-esteem can be consid-

Secondary but not primary negative ered as one of the most important areas in solving the issues of
symptoms of schizophrenia are differential diagnosis between transsexualism and gender iden-
tity disorders in endogenous diseases. The purpose of this research
associated with carriage of minor was to assess self-esteem peculiarities in women with intention to
allele of genetic polymorphism sex reassignment. The study involved 18 women diagnosed with
MTHFR677C>T schizotypal disorder and 12 women diagnosed with transsexual-
T. Zhilyaeva1* , A.V. Sergeeva2 , A.S. Blagonravova2 , G.E. Mazo3 ism. The age of the participants was from 18 to 25 years and was
1 Privolzhsky Research Medical University, Department of Psychiatry comparable in both groups.
and Medical Psychology, Nizhny Novgorod, Russia; 2 Privolzhsky Methods.– Clinical, sexological and clinical-psychological methods
Research Medical University, Research Institute of Preventive were used. Psychological assessment has been conducted using
Medicine, Nizhny Novgorod, Russia; 3 V.M. Bekhterev’ National MMPI, “Draw a man” – Machover test, Luscher Color Test, and
Medical Research Center for Psychiatry and Neurology, Department Dembo-Rubinstein Method of Self-esteem Measurement.
of endocrinologycal psychiatry, Saint-Petersburg, Russia Results.– For women with schizotypal disorder: the presence of dys-
* Corresponding author. morphophobic experiences and rejection of the corporeality (93%);
contradictory self-attitude: from experiences of uniqueness to infe-
Background and aims.– J.L. Roffman et al. reported (2011) that riority, with negative emotional coloring of the self-image (93%);
folate metabolism disturbances (T-allele carriage of genetic poly- weak interiorization and undifferentiation of the male gender role
morphism of folate metabolism key enzyme MTHFR677C>T) are (100%); low self-esteem (89%). For women with transsexualism:
associated with severity of negative symptoms of schizophrenia. general disharmony of self-attitude (58.3%); rejection of the corpo-
In those study patients received antipsychotics, so it is impossible reality (66.7%); positive emotional coloring of the self-image (83%);
to exclude the secondary pharmacogenic nature of negative symp- self-esteem maintaining is possible only through the internaliza-
toms. The purpose of this study was to evaluate the association of tion of the male gender role. In both groups: an incompleteness of
T-allele of MTHFR677C>T with the severity of negative symptoms of the self-image and the fear of being rejected by society.
schizophrenia at different stages of treatment to exclude the phar- Conclusions.– Comparison of self-esteem features in the studied
macogenic nature of the negative symptoms associated with folate groups revealed possible differential diagnostic criterions: the
deficiency. degree of severity of contradictions in the structure of self-attitude,
Methods.– Patients with schizophrenia were examined with PANSS the negativity of self-perception, low self-esteem. High suicidal
during the treatment in hospital (more than 10 days, n = 106), and activity in both groups may be due to negative contradictory self-
in the first 1-3 days from the admission to hospital (n = 59) when esteem and the difficulties of self-actualization.
the impact of antipsychotic treatment was minimal and examined Disclosure of interest.– The authors have not supplied a conflict of
by the PCR method for the carriage of alleles of polymorphism interest statement.
MTHFR677C>T. Both groups of patients were comparable by gen-
der, age, distribution of alleles of MTHFR677C>T.
Results.– Carriers of the T-allele vs patients with wild genotype E-PP1201
after 10 days of treatment had the greater severity of some nega- Group psychotherapy experience with
tive symptoms: affect flattening (p = 0.029), passive-apathic social
seclusion (p = 0.014), stereotyped thinking (p = 0.044), which is con-
transgender individuals in Turkey
A. Polat* , F. Alioglu
sistent with the results of J.L. Roffman. However, patients who
Kocaeli University, Department of Psychiatry, Kocaeli, Turkey
were examined at the begining of hospitalization had no differ- * Corresponding author.
ences in the severity of negative symptoms between subgroups
with/without T-allele. Background and aims.– Gender dysphoria is a situation that has a
Conclusions.– More pronounced negative symptoms in patients long history, and also known to be present in different cultures.
with T-allele in comparison with patients with “wild” CC genotype The psychiatrist who manages the process of gender transition pro-
examined during inpatient treatment may be antipsychotic- cess applications in Turkey is in the position of people working in
induced secondary negative symptoms, but not primary symptoms a multidisciplinary team is recommended, but this may not always
of schizophrenia. be possible in practice.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Trans people who initiate the gender transition pro-
interest statement. cess after appropriate legal applications can have their psychiatric,
endocrinological and surgical treatments legally. Kocaeli University
Hospital is a center that monitors the gender transition pro-
cess since 2004. Individuals who are admitted to our clinic with
E-Poster Presentation: Sexual Medicine and
the complaint of gender dysphoria are included in the gender-
Mental Health monitoring program and followed up through individual and group
psychotherapy.
Results.– All trans individuals who are followed up in our clinic
E-PP1200 and are considered to be suitable are referred to the trans support
Peculiarities of self-esteem in young groups performed monthly. Sessions with an average of 10–15 par-
women with gender dysphoria and ticipants and open group are held for 90 minutes on the last Monday
intention to sex reassignment of each month. Individuals who are not fit for group treatment or
E. Pervichko1* , G. Alekseeva2 who are not ready yet continue their individual therapy. Family
1 Lomonosov Moscow State University, Faculty of Psychology, information and support meetings are also held for the families of
Moscow, Russia; 2 V. Serbsky Federal Medical Research Centre of individuals who are in the transition period.
Psychiatry and Narcology of the Ministry of Health of the Russian Conclusions.– It can be said that gender transition process is cur-
Federation, Department of Sexology and Therapy sexual rently the best way to reduce the effects of gender dysphoria. The
Dysfunctions, Moscow, Russia aim of this presentation is to share our clinical experience about
* Corresponding author. gender transition process, where there is no standard treatment
protocol yet in Turkey.
Disclosure of interest.– The authors have not supplied a conflict of Conclusions.– The most common sexual dysfunction admitted to the
interest statement. outpatient clinic for sexual dysfunction in Turkey is genito-pelvic
pain/penetration disorder. The detailed sexual history of both part-
ners, which reported avoidance behaviors, traumatic experiences
E-PP1202 and past sexual activities will contribute positively to treatment.
Fetishistic disorder. Clinical features Disclosure of interest.– The authors have not supplied a conflict of
and treatment. A review interest statement.
H. Saiz Garcia1* , S. Trincado Robles2
1 Unidad Docente Salud Mental de Navarra, Psychiatry, Pamplona,
Spain; 2 Red de Salud Mental de Vizcaya, Psychiatry, Bilbao, Spain E-PP1204
* Corresponding author. Bisexual and ashamed
D. Sendler
Background and aims.– Paraphilia is an infrequent cause of atten- Felnett Health Research Foundation, Laboratory of Forensic Sexology,
dance at a Psychiatry Service. When patients attend because of this Legal Medicine, and Digital Ethnography, Staten Island, USA
disease, it’s because it generates a big disturbance on their lifes. Background and aims.– This study explores under-investigated area
The most frequent cause of paraphilia in men is voyeurism and of research — the cultural comparison of the coming out experience
fetishism (1). of bisexual women, who do not accept their bisexuality.
Methods.– A review was conducted aiming to clarify the treatment Methods.– In-depth interview study of New York (n = 22) and War-
of this illness and its clinical features in order to distinguish from saw (n = 20) bisexual women were conducted between April–July
other neurological or psychiatric diseases. The literature search was 2017. Participants were recruited from among members of the pop-
conducted in PubMed data reviewing articles dating between 1983 ular, urban, gay, non-profit resource centers, serving the LGBTQ
and 2018. communities in each city.
Results.– Results.– Through qualitative analysis, identified were the following
1. Most paraphilic disorders have a high rate of comorbidity with themes: feeling disoriented; feeling disgust when being attracted
other psychiatric disorders. to same sex; admiration of a “beautiful body” as a feature of being
2. The best treatment method for paraphilia is the combination of bisexual; rationalizing bisexuality; and reaching self-acceptance.
cognitive behavioral and drug treatment. Bisexual women feel disoriented because they wish to control
3. Drugs used for the treatment of paraphilia include selec- their sexual urges toward both genders, but cannot achieve it;
tive serotonin reuptake inhibitors (SSRI), cyproterone acetate, it leads them to sexually experimenting with women and men,
medroxyprogesterone, and GnRH analogues. and feeling guilty about it thereafter. A quarter of our sample
4. Some of these drugs use depot formulations. believe that bisexuality makes them improperly labeled as des-
Conclusions.– The evolution of this disorder is usually insidious. The perate for sex, misunderstood as a “player,” or a “fool.” For these
treatment of fetishistic disorder should include multidisciplinary women, the strongest concern is dating other people— that is, what
interventions, including CBT and drug treatment, although it’s not will a prospective romantic partner think about me, when he/she
effective in all cases. Further investigations is needed in order to finds out that I am “bi.” These nuances expose the problem of
find better approaches of treatment. not fully understanding what makes up one’s sexuality — that is:
Disclosure of interest.– The authors have not supplied a conflict of no one cannot fully control their sexual preferences through con-
interest statement. stant rationalization. This ongoing rumination results in long-term
psychiatric distress associated with one’s sexual orientation and
gender identity.
E-PP1203 Conclusions.– Reaching self-acceptance as bisexual woman is non-
Sociodemographic characteristics of linear — many women never reach the stage where they can
patients with genito-pelvic proudly say “I am bi.”
pain/penetration disorder Disclosure of interest.– The authors have not supplied a conflict of
D. Sarikaya* , O. Gunday Toker, E. Sagaltici, S.E. Teker, S. Gumus interest statement.
Sanli
Health Sciences University Bagcilar Research and Training Hospital,
E-PP1205
Department of Psychiatry, Istanbul, Turkey
* Corresponding author. Chastity cages for naughty boys —
implications for penile anatomy,
Background and aims.– Vaginismus means an involuntary contrac- mechanisms of trauma, and possible
tion of the muscles in the outer third of the vagina that causes the
woman pain and/or coital difficulties. In DSM 5 that the diagnoses
source of long-term psychiatric
of vaginismus and dyspareunia be collapsed into a single diagnostic trauma
entity called “genito-pelvic pain/penetration disorder. In this study, D. Sendler
we aimed to determine the sociodemographic characteristics of the Felnett Health Research Foundation, Laboratory of Forensic Sexology,
patients with genito-pelvic pain disorder who applied to our sexual Legal Medicine, and Digital Ethnography, Staten Island, USA
dysfunction outpatient unit in Istanbul. Background and aims.– In the context of gay sadomasochistic rela-
Methods.– Our clinicians, who were also sexual therapists, had a tionships, the practice of locking up submissive player (SP) in
detailed interview with the patients who were admitted to our unit chastity is meant to ensure that the dominant master (DM) is the
and were diagnosed as genito-pelvic pain/penetration disorder. only person ejaculating for pleasure; by proxy, the DM controls
Sociodemographic characteristics, duration of disease, previous their partner’s psychological experience of pleasure.
treatment applications and detailed sexual history were recorded. Methods.– This study is based on clinical data on male SP, who expe-
Results.– 22 patients were included in the study. The mean age of the rienced trauma while wearing a chastity devices. The main findings
patients was 25.4. 54.5% of the patients completed high school or are a summary of physical examination, psychosexual interviews,
higher education level (2 of them graduate of college). The average and follow-up evaluations.
time period between the first encounter of the patients with this Results.– The first patient is a 35 years-old Caucasian male, who
sexual dysfunction and their applications to our clinic was 16.2 used to wear permanent chastity ring, surgically tied around the
months. base of his penis and scrotum. The device had to be removed due
to infection, prompting him to seek alternative methods of attain- USA; 2 Institute of Psychiatry and Neurology, III Department of
ing permanent chastity. He requested to have his pelvic splanchnic Psychiatry, Warsaw, Poland
nerve plexus severed to remove the possibility of getting erec- * Corresponding author.
tions. The other cases are of 4 individuals, age range 22–51, who
presented with painful erections, starting 2 weeks after wear- Background and aims.– Professional gay sadomasochism is a sex-
ing a chastity cage. In addition to presenting psycho-sexological ual practice involving for-fee role playing with infliction of pain
analysis, our data highlight challenges related to two aspects of to achieve sexual pleasure–all provided by experienced dominat-
medical practice— ethics and sexological treatment planning. First, ing partner (DP). We qualitatively examined coping strategies that
we are treating patients, who are willingly experiencing pain to prevent submissive sadomasochists (SP) from experiencing long-
give another person, the DM, full sexual pleasure. Second, we need term negative psychological trauma associated with participating
to decide what is the ethical solution for providing treatment to in painful sex.
these individuals — that is, whether medical providers should ever Methods.– We studied 320 gay sadomasochists (172 dominant, DP;
counsel patients on how to alter their anatomy and physiology to 148 submissive, SP) who have been part of kink culture for at
attain desirable sexual satisfaction. least 2 years. Eligible participants were recruited online for mixed
Conclusions.– Wearing chastity devices may result in long-term methods study, involving qualitative analysis and administration
psychiatric trauma. of surveys.
Disclosure of interest.– The authors have not supplied a conflict of Results.– There are three themes characterizing similarities
interest statement. between Polish and American professional gay sadomasochists:
consent, sexually transmitted disease prevention (STDs), pro-DP
culture, psychological pleasure. Consent uniformly ensures the
E-PP1206 safety of SPs; 28% report having tried extreme kink, when con-
American medical students’ attitudes sent to specific behaviors was verbalized and provided in writing.
STD transmission is minimized thanks to participating in pre-
toward counseling HIV+ gay male
meeting video-interview screening, conducted by DP; during this
patients in an outreach program of an e-interview, the DP reviews past history of sexual behaviors of the
Eastern European sexual behaviors SP and provides safety guidelines before meeting in person for
clinic kink session. Pro-DP, in exchange for money, provide safe sexual
D. Sendler environment for SP, including guiding SP to psychosexual health
Felnett Health Research Foundation, Laboratory of Forensic Sexology, resources, if they experience some physical trauma during con-
Legal Medicine, and Digital Ethnography, Staten Island, USA sensual kink sex. By promoting proper communication and safety
Background and aims.– This study qualitatively assesses communi- features, professional DPs provide SPs with customized psychosex-
cation skills and first impressions of second-year medical students, ual support that minimizes risk of long-term psychological trauma
who had experience performing medical consults with HIV+ gay associated with rough sex.
male patients (HGMP). Conclusions.– SPs practicing rough BDSM are better off hiring
Methods.– We conducted semi-structured interviews with Amer- professional DPs, if they want to minimize risk of long-term psy-
ican medical students (N = 20, 10 M and 10F), completing medical chosexual trauma.
degree abroad, and rotating through sexual behaviors clinic. Disclosure of interest.– The authors have not supplied a conflict of
Results.– Nearly 83% of students report feeling inadequately pre- interest statement.
pared to counsel HGMP in outpatient clinical setting. Among
primary obstacles were poor communication skills, difficulty with
managing complex list of medications, and issues with trans- E-PP1208
ferring information to supervising physician. Significant number Affective temperaments in patients
of male participants (58%) and smaller share of females (∼25%) with lifelong vaginismus and their
reported experiencing all of these problems due to feeling uncom- male partners
fortable with the patient’s sexuality. Male participants reported a N.G. Usta Sağlam1* , H. Bakay2 , M.E. Gökler3 , Ş. Turan4
range of feelings associated with treating HGMP — the strongest 1 Gaziosmanpaşa Taksim Training and Research Hospital, Psychiatry,
being embarrassment (∼72%), incompetence (28%), shyness (12%), Istanbul, Turkey; 2 Nizip State Hospital, Psychiatry, Gaziantep,
and moral superiority (∼8%) . Females felt compassionate (83%), Turkey; 3 Ankara Yıldırım Beyazıt University, Public Health, Ankara,
embarrassed (29%), empowered (27%), enlightened (19%), and Turkey; 4 Istanbul University-Cerrahpaşa, Psychiatry, Istanbul,
incompetent (11%). Turkey
Conclusions.– This study offers a look into how American stu- * Corresponding author.
dents studying medicine in Poland experience unique challenges in
exercising proper clinical and communication skills in counseling Background and aims.– Temperament describes attitudes and
HGMP. Various reasons, including social, religious, and perception behaviors that stand on constitutive, genetic and biological bases,
of physical look, influence the quality of care provided by these and it has been stated clinically to be linked to psychiatric disorders.
doctors-to-be. Temperament characteristics of both lifelong vaginismus (LLV) and
Disclosure of interest.– The authors have not supplied a conflict of their male partners may be important in the development or con-
interest statement. tinuation of LLV. The present study aimed to investigate affective
temperaments in patients with LLV and their male partners.
Methods.– We performed a prospective and comparative study
E-PP1207 investigating affective temperaments in patients with LLV and their
Gay BDSM: a cross-cultural male partners. Fifty-six patients with LLV, their 56 male partners,
comparison of psychiatric wellness of and 44 healthy couples with no complaints of any sexual function as
Polish and American professional gay a control group were included in this study. The Temperament Eval-
uation of Memphis, Pisa, Paris and San Diego Autoquestionnaire
sadomasochist (TEMPS-A) was completed by all participants.
D. Sendler1* , M. Lew-Starowicz2
1 Results.– TEMPS-A scores were significantly higher in patients with
Felnett Health Research Foundation, Laboratory of Forensic
LLV for depressive (OR = 1.27), cyclothymic (OR = 1.31), anxious
Sexology, Legal Medicine, and Digital Ethnography, Staten Island,
(OR = 1.22), and irritable (OR = 1.22) temperament compared to
female controls, whereas there was no significant difference in Background and aims.– Common symptoms of OSA and depression
the hyperthymic temperament scores between these two groups such as sleepiness and fatigue make difficulties in determining the
(OR = 1.03). Additionally, depressive (OR = 1.31) and cyclothymic presence of either of them clinically and psychopharmacotherapy
(OR = 1.18) temperaments scores (OR = 1.13) were significantly could worsen the symptoms. Aims: To present a patient misdiag-
higher in male partners of patients with LLV compared to male nosed and inadequately treated for several years.
partners of female controls. Methods.– Case report of a 58 years old obese male patient treated
Conclusions.– The results of this study support the idea that both several years as COPD and lately as depression with SSRI, SGA,
patients with LLV and their male partners have different affective anticholinergics. CT and MRI revealed global cortical atrophy and
temperament characteristics compared to healthy couples. micro-vascular changes. Actual psychiatric evaluation was because
Disclosure of interest.– The authors have not supplied a conflict of of hypersomnolence and dysarthria.
interest statement. Results.– Heteroanamnesis - data for snoring. Epworth Sleepiness
Scale (ESS) was 20/24. EEG: theta/slow alpha activity and slow
waves. Psychopharmacotherapy was ceased. Month later his men-
E-PP1209 tal health improved with ESS score 14/24. Second EEG: slow wave
Impact of psychosis on sexual sleep patterns and pulse-oximetry was 92%. Polysomnography test
functioning: a systematic review of with noted severe snoring, sleep onset at 6,5 minutes without
REM phase, sleep efficiency was 68,5% and total arousal index was
the last 10 years
89,7/hour. Hypopneas/apneas with average oxygen saturation of
S. Vargas* , M.F. Mantilla
91% and maximal reduction at 63%, respiratory disturbance index
Hospital Vall d’Hebron, Psychiatry Unit, Barcelona, Spain
* Corresponding author. (RDI) was 75,9/hour. Treated with continuous positive airway pres-
sure (CPAP).
Background and aims.– Sexual dysfunction figures prominently in Conclusions.– Depression should be considered as secondary in
patients with psychotic disorders, and may be related to the disease patients with OSA and severity correlates more with EDS than with
itself, psychosocial factors, somatic health and the use of psy- hypoxemia. This could lead to inadequate treatment and worsening
chotropic medications. However, a limited number of studies have of the disease with psychopharmacotherapy because CPAP treat-
evaluated sexual functioning in patients with psychosis without ment is necessary that markedly improve depressive symptoms. In
medication influence. countries without sleep centers close cooperation between pulmo-
This study aimed to assess the current evidence about the impact nologists and psychiatrists is needed and also education of medical
of psychosis itself on sexual functioning. students and doctors about sleep breathing disorders to recognize
Methods.– A systematic review was carried out in MEDLINE and treat the disorder effectively.
(PubMed) database, selecting articles published in English in the Disclosure of interest.– The authors have not supplied a conflict of
last 10 years that include the study of sexual functioning and psy- interest statement.
chosis, in unmedicated patients or with little use of psychotropic
medications.
Results.– Data were extracted from 7 cross-sectional studies and 1 E-PP1211
longitudinal study. There were 681 people with first-episode psy- Correlations of sleep difficulties: the
chosis, 47 people with ultra-high risk for psychosis and 264 people role of optimism/pessimism,
with schizophrenia or schizoaffective disorder. The prevalence of psychological disturbance and
sexual dysfunction ranged from 37.8% to 70%, affecting all phases
cognitive emotional regulation
of sexual function. In a study, sexual dysfunction was more pro-
B. Rodrigo Afonso1 , M.J. Soares1 , M. Marques2* , A. Araújo3 , A.T.
nounced in first-episode psychosis than in ultra-high risk, however
Pereira1 , S.C. Bos1 , A.P. Amaral4 , A. Macedo1
in another article, it was similar. The severity of psychotic symp- 1 Faculty of Medicine, University of Coimbra, Department of
toms was correlated with severity of sexual dysfunction. Negative
Psychological Medicine, Coimbra, Portugal; 2 Faculty of Medicine,
symptoms were the most important.
Coimbra University FMUC, Coimbra Hospital and Universitary Centre
Conclusions.– This systematic review states that both positive and
CHUC, Coimbra, Portugal; 3 Faculty of Medicine, University of
negative symptoms, along with the severity, impact negatively
Coimbra, Department of Psychological Medicine, Coimbra, Portugal; 4
sexual functioning, even before the onset of psychosis itself and
Faculty of Medicine, Coimbra University, Department of
medication.
Psychological Medicine FMUC, Coimbra, Portugal
Background and aims.– Optimism and pessimism are two dispo-

E-Poster Presentation: Sleep Disorders & Stress / sitional traits that reflect positive/negative expectations about the
Substance related and Addictive disorders - Part V future and the expectation of favourable/unfavourable outcomes. A
key aspect that distinguishes them is the way they influence subjec-
tive coping experiences and problem solving, which is also reflected
Disclosure of interest.– The authors have not supplied a conflict of in sleep. An optimistic perspective reduces concerns and improves
interest statement. sleep directly through adaptive sleep habits and indirectly through
more effective adaptive problem solving strategies. On the other
hand, pessimism is related to negative affect, psychological distur-
E-PP1210 bance, and less adaptive coping strategies, such as avoidance and
Misdiagnosed adult obstructive sleep withdrawal. This study aims to analyze how optimism/pessimism,
apnea treated as depressive disorder cognitive emotional regulation and psychological disturbance are
N. Manusheva1* , V. Videnova2 , D. Karkinski3 associated with sleep difficulties.
1 University Psychiatry Clinic, Psychophysiology, Skopje, FYR Methods.– 253 university students (77.9% females), aged between
Macedonia; 2 Psychiatric Hospital Skopje, Department for Emergency 18–25 years, completed the Portuguese versions of DASS-21, OP-2,
Psychiatry, Skopje, FYR Macedonia; 3 Clinic for Pulmonology and and CERQ questionnaires. Three questions were used to evaluate
Alergology, Department for Sleep Medicine, Skopje, FYR Macedonia sleep difficulties and to calculate the sleep difficulties index (SDI).
Results.– 10.3% of the students scored one standard deviation work and high level of lead in body may cause insomnia. Its conse-
above the mean on SDI. Optimism, CERQ1-Positive reappraisal quence is less effective performance of daytime activities, excessive
and planning and CERQ-Positive were negatively associated with sleepiness, concentration, focus problems.
SDI whereas pessimism, CERQ3-Rumination, CERQ6-Self-Blame, Methods.– Investigated and control group completed AIS ques-
CERQ8-Catastrophizing, CERQ-Negative and DASS-21 (Depression, tionnaire. Lead and ZPP levels analyzed available from recent
Anxiety, Stress and Total score) were positively associated with periodic/control studies.
sleep difficulties (SDI). Results.– AIS score was significantly higher in investigated group
Conclusions.– These results highlight the importance of the dispo- (29.5% vs 8.4%). Comparison of tested subgroup with control
sitional traits optimism and pessimism, cognition and affect in the showed no significant differences, only slightly more respondents
aetiology and maintenance of sleep difficulties. This study brings from no-shift work system subgroup tested score 8 or more points.
new insights to the prevention and intervention on psychological The same was observed when shift work system workers and no-
disturbance and associated comorbidities, such as sleep difficulties. shift work system workers were compared in nvestigated group.
Disclosure of interest.– The authors have not supplied a conflict of The largest percentage of workers with insomnia was in shift work
interest statement. system subgroup of study group. Slightly higher average level of
lead and ZPP in shift work system subgroup, and the difference was
not statistically significant. Probability of insomnia was determined
E-PP1212 according to concentration of lead and ZPP in body. As the level of
The big-five personality traits, lead and ZPP increases in investigated group and so the probabil-
perseverative thinking, psychological ity of insomnia increases. It is the largest among the investigated
group working in a shift work system.
distress and ocd symptoms as
Conclusions.– Incidence of insomnia assessed with AIS in group
correlates of sleep difficulties is significantly higher than in control. The highest percentage of
D. Lopes1 , M.J. Soares1 , M. Marques2* , A.T. Pereira1 , A. Araújo3 , S.C. people with insomnia was in shift work system subgroup of inves-
Bos1 , A.P. Amaral4 , A. Macedo1 tigated group. As the level of lead in blood increases, the likelihood
1 Faculty of Medicine, Coimbra University, Department of
of insomnia is increased.
Psychological Medicine, Coimbra, Portugal; 2 Faculty of Medicine, Disclosure of interest.– The authors have not supplied a conflict of
Coimbra University FMUC, Department of Psychological Medicine interest statement.
FMUC, Coimbra, Portugal; 3 Faculty of Medicine, Coimbra University
FMUC, Department of Psychological Medicine FMUC, Coimbra,
Portugal; 4 Faculty of Medicine, Coimbra University FMUC, E-PP1214
Department of Psychological Medicine FMUC, Coimbra, Portugal
Personality characteristics of
middle-age patients with essential
Background and aims.– Sleep difficulties in university students are hypertension and increased
associated with negative outcomes, at academic, cognitive, social, variability of blood pressure: a
health and well-being levels. The present study aims to analyse the
landscape of challenges
relationship between the Big-five personality traits, OC symptoms,
E. Pervichko1* , O. Ostroumova2 , E. Borisova3
psychological distress, perseverative thinking (PT) and global sleep 1 Lomonosov Moscow State University, Faculty of Psychology,
difficulties.
Moscow, Russia; 2 I.M. Sechenov First Moscow State Medical
Methods.– 247 university students, mostly women (78.9%),
University, Clinical Pharmacology Department, Moscow, Russia; 3
Medicine/Dental Medicine students (86.6%), aged 18–25, com-
City Clinical Hospital named after E.O. Mukhin Department of Health
pleted the Portuguese versions of the MOCI, the NEO-FFI, the PTQ
of Moscow City, Department of General Medicine, Moscow, Russia
and the DASS-21. The sleep difficulties were assessed using three * Corresponding author.
questions, with a sleep difficulties index (SDI) being calculated by
summing their scores. Background and aims.– Modern medicine postulates that one of
Results.– 18.2% of the students scored =/> one standard deviation the reasons for disregulation of blood pressure (BP) is prolonged
above in SDI. Sleep difficulties were positively correlated with emotional tension in stress conditions.
gender (female), with psychological distress and its dimensions The purpose of this research was to conduct an analysis of person-
(anxiety, depression and stress), with PT and its dimensions, with ality characteristics of middle-age EH patients with increased BP
OC symptoms (doubts and rumination) and with the personality variability when compared to patients with normal BP variability.
traits, especially neuroticism, and negatively with the personality Methods.– The study involved 59 patients with increased BP vari-
traits conscientiousness and extroversion. ability, average age was 53.6 ± 6.1, and 41 EH patients with normal
Conclusions.– Sleep difficulties (SD) are associated with personality BP variability, average age was 50.2 ± 7.3. All of patients had
traits, PT, OC symptoms and psychological distress. These variables uncomplicated EH, stage 1–2. Participants performed the follow-
might contribute to the aetiology and maintenance of SD. Present ing assessment: Sixteen Personality Factor Questionnaire (16PF),
results may have clinical implications on the therapeutic approach Ways of Coping Questionnaire (WCQ), Cognitive Emotion Regu-
to sleep difficulties and their comorbidities. lation Questionnaire (CERQ), and Multidimensional Perfectionism
Disclosure of interest.– The authors have not supplied a conflict of Scale by P. Hewitt and G. Flett.
interest statement. Results.– EH patients from group 1 differ from the second group
patients by higher rates Q1-factor (Openness to change, Flex-
ibility) (5,93 ± 1,99 vs 4,95 ± 2,31; p = 0,04), and lower rates of
E-PP1213 factor O (Apprehension, worrying, self-blaming) (3,98 ± 1,76 vs
Insomnia among employees of the 5,05 ± 1,94; p = 0,006) and factor Q4 (Tension, Frustration, Over
Zinc Steelworks wrought) (4,14 ± 1,76 vs 5,08 ± 2,01; p = 0,018) - in 16PF. However,
N. Pasierb the first group patients are significant more often use a “Refocus on
˛
Ślaski Uniwersytet Medyczny, Katedra Psychiatrii, Ossy, Poland planning” (16,0 ± 3,0 vs 15,1 ± 2,9; p = 0,01) as an effective strategy
Background and aims.– Aim is to assess insomnia among employees of regulating emotions in CERQ, and they have significantly lower
of Zinc Steelworks by Athens Insomnia Scale and influence of harm- scores on the scale “Other-oriented perfectionism” (45,5 ± 16,9 vs
ful factors at workplace on sleep and daytime functioning. Shift 52,1 ± 15,4; p = 0,03).
Conclusions.– The results show the “psychological complexity” of mentation in healthy subjects (Rasskazova et al., 2014) and could
EH patients with increased BP variability. It is permissible to assume be a factor of insomnia.
that they significantly more frequently than patients from the sec- The aim was to compare effects of attention to sleep, wakefulness
ond group are more prone to repression of their emotions. and to sleep hygiene (as control condition described as effective in
The research was supported by RFBR; project № 17-06-00954. behavioral models) in good sleepers.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– 123 adults (83 females) 19–45 years old without sleep
interest statement. disorders were randomly assigned to three conditions for 7 days: 35
were asked to use any possible strategies to improve their sleep, 42
– their wakefullness and 47 – sleep hygiene. For 2 days before and 2
E-PP1215 days at the end they appraised every evening their day (using 0–10
Anxiety and depression are related to Likert scale) and every morning filled Glasgow Content of Thoughts
subjective and objective sleep quality Inventory (Harvey, Espie, 2004) and Sleep Diary (Morin, 1993).
Results.– Any attempts to improve “sleep-wake cycle” led to bet-
in sleep apnea but not in insomnia
ter sleep and alertness in the morning appraisals (F = 9.10–13.34,
E. Rasskazova1* , G. Kovrov2 , A. Machulina3
1 p < .01, 2 = .11) as well as higher day-time achievement and less
Moscow State University, Clinical Psychology, Moscow, Russia; 2
thoughts before sleep (F = 3.18–3.21, p < .05, 2 = .03). Increase in
I.M. Sechenov First Moscow State Medical University, Department of
day-time achievement tended to be more prominent in those
Pathology of Vegetatic Nervious System, Moscow, Russia; 3 Brothers
improving wakefulness (F = 1.92, p < .08, 2 = .03). Emotions tended
Bahrushins’ Moscow Clinical Hospital, Neurology, Moscow, Russia
* Corresponding author. to improve after experiment in those concentrating on wakefulness
and on sleep (F = 1.81, p < .10, 2 = .03).
Background and aims.– There is a wide range of studies of anxiety Conclusions.– Results support that in good sleepers any strategy
and depression as factors triggering and perpetuating insomnia. could be effective with two marginal effects in favor of concentra-
However, to explain insomnia by anxiety or depression one should tion on wakefulness and sleep comparing to hygiene. Research is
prove that in insomnia (but not in other sleep disorders) they lead supported by the Russian Foundation for Basic Research, project
to poorer sleep. No. 18-013-01211.
The aim was to compare relationships of anxiety, depression and Disclosure of interest.– The authors have not supplied a conflict of
sleepiness with sleep of patients with insomnia and sleep apnea. interest statement.
Methods.– Sleep of 93 patients with chronic insomnia and 46
with sleep apnea was recorded with polysomnography. They
filled Insomnia Severity Index (Morin, 1993), Hospital Anxiety E-PP1217
and Depression Scale (Zigmond, Snaith, 1983), Epworth Sleepiness Long-term efficacy and safety of
Scale (Johns, 1991). pediatric prolonged-release
Results.– Anxiety, depression and insomnia severity were higher melatonin for insomnia in children
in insomnia while sleepiness was higher in sleep apnea
with autism spectrum disorder
(2 = 7.46–10.30, 2 = .07-.17, p < .01). However, neither anxiety nor
T. Nir1 , C. Schroder2* , A. Maras3 , B. Malow4 , P. Gringras5 , R.
depression in insomnia were related to objective or subjective sleep
Findling6 , N. Zisapel7
parameters (r < .15) but they did correlate with sleepiness (r = .20- 1 Neurim Pharmaceuticals, Clinical and Regulatory Affairs, Tel Aviv,
.24, p < .05). In patients with sleep apnea depression was higher in
Israel; 2 Strasbourg University Hospital, Department of Child and
those with longer sleep latency (r = .30, p < .05) and lower sleep effi-
Adolescent Psychiatry, Strasbourg, France; 3 Yulius Academy, Yulius
cacy (r = −.34, p < .05) while anxiety was related to longer delta sleep
Mental Health Organization, Barendrecht, The Netherlands; 4
latency (r = .44, p < .01). Both depression and anxiety were related
Vanderbilt University Medical Center, Sleep Division, Department of
to poorer subjective sleep (r = −.46 to −.39, p < .01) and depression
Neurology, Nashville, USA; 5 Children’s Sleep Medicine, Evelina
correlated to sleepiness (r = .32, p < .01).
London Children’s Hospital, Guy’s and St Thomas’, London, United
Conclusions.– Although anxiety and depression affect insomnia,
Kingdom; 6 Kennedy Krieger Institute/ Johns Hopkins University,
they seem to be nonspecific factors leading to poorer sleep in other
Department of Psychiatry and Behavioral Sciences, Baltimore, USA; 7
disorders. Moreover, it is possible that in chronic insomnia they
Neurim Pharmaceuticals, Medical Affairs, Tel Aviv, Israel
do not affect sleep anymore being a reaction to daytime function- * Corresponding author.
ing problems. Research is supported by the Russian Foundation for
Basic Research, project No. 17-06-00363. Background and aims.– To investigate PedPRM (2,5,10 mg) long term
Disclosure of interest.– The authors have not supplied a conflict of efficacy and safety in patients receiving 1 year of PedPRM, as well
interest statement. as caregivers outcomes.
Methods.– A prospective 9-months open-label follow up study of
efficacy and safety of PedPRM in community dwelling patients
E-PP1216 with ASD/NGD. Sleep measures included the validated caregivers’
The role of attention in changes of Sleep and Nap Diary (SND) and Composite Sleep Disturbance Index
“sleep-wake cycle”: comparing day (CSDI). Caregiver measures included Pittsburgh Sleep Quality Index
and night effects of attempts to (PSQI) and quality of life (WHO-5 well-being index).
Results.– The improvements in total sleep time (TST), sleep latency
improve wakefulness, sleep and sleep
(SL) and duration of uninterrupted sleep (longest sleep episode)
hygiene seen in the double blind-phase with PedPRM vs placebo were
E. Rasskazova1* , S. Leonov2 maintained throughout the follow up period. Subjects treated
1 Moscow State University, Mental Health Research Center, Clinical continuously with PedPRM for 52 weeks (N = 41) slept on aver-
Psychology, Moscow, Russia; 2 Moscow State University, age 62.08 minutes longer (p = 0.007), fell asleep −48.6 minutes
Methodology of Psychology, Moscow, Russia faster (p < 0.001) and had longer uniterrupted sleep duration
(89.1 minutes; p = 0.001). In addition, quality of sleep improved
Background and aims.– According both to attention-intention-effort (p < 0.001) and number of awakenings decreased > 50% (p = 0.001).
model (Espie et al., 2006) and body functions regulation model In parallel, there were statistically significant and clinically relevant
(Tkhostov, 2002) excessive attention to sleep lead to sleep frag- improvements in Child’s sleep disturbance and parents satisfaction
of their child’s sleep patterns (CSDI), caregiver’s sleep quality (PSQI) Avoid exposure to bright light at night (SH3), Avoid heavy meals
(p < 0.001 for all) and quality of life (WHO-5) (p = 0.001) in all com- (SH4), Enhance your environment by making sure the bedroom is
pleters regardless of randomization history (N = 79). PedPRM was quiet, dark, and comfortable (SH5), Avoid caffeine, alcohol before
generally safe; the most frequent treatment related adverse events bed (SH6), a relaxing bedtime routine (SH7), a light bedtime snack
were fatigue in 5.3% (5 events) and mood swings in 3.2% (3 events) (SH8), Remove the bedroom clock (SH9), Go to bed only when
of patients. sleepy (SSC1), Use the bed or bedroom only for sleeping or sex
Conclusions.– PedPRM is an effective and safe treatment option for (SSC2), Get out of bed when unable to sleep (SSC3), Get up at
long term (52 weeks) treatment of children with ASD suffering from the same time (SSC4), Avoid napping (SSC5). The degree of sleep
insomnia and consequently improved caregivers well–being. skill state was evaluated by Likert scale and compared between
Disclosure of interest.– The authors have not supplied a conflict of before and after CBT. After 3 months, patients were divided into
interest statement. two groups: still need of hypnotics and no need of hypnotics, and
compared in changes of sleep skills.
Results.– Forty-six (35.1%) patients replied they needed not
E-PP1218 hypnotics any more, but 85 (64.9%) patients replied they
Sleep disorders for chronic pain still needed hypnotics after CBT. Sleep VAS (25.26 ± 8.52 vs.
G. Shevtsova1* , O. Zagorulko2 , L. Medvedeva2 , I. Malenkova2 32.64 ± 8.95, p < 0.001), SH2 (3.67 ± 0.92 vs. 2.76 ± 1.06, p = 0.030),
1 First Moscow State Medical University, Department of Nervous SH7 (4.08 ± 0.55 vs. 2.76 ± 0.76, p < 0.001) were different in two
Diseases and Neurosurgery, Moscow, Russia; 2 National Research groups.
Centre of Surgery, Pain Department, Moscow, Russia Conclusions.– Among several CBT skills, regular moderate exercise
* Corresponding author. in daytime and a relaxing bedtime routine seem to be key compo-
nents.
Background and aims.– Sleep disorders are common with a fre- Disclosure of interest.– The authors have not supplied a conflict of
quency of 10–20% among patients of outpatient department, and interest statement.
for patients with chronic pain it reaches 70%.
Aims. Assess the type and frequency of sleep disorders in patients
with chronic nonspecific low back pain E-PP1220
Methods.– A study was made of the patterns of sleep disorders in 30 Health and gender differences in
patients with acute and 30 with chronic nonspecific low back pain.
relation to stress response
The intensity of pain was assessed on a subjective visual analogue
P.J.M. Van Wijngaarden-Cremer
scale, sleep disturbances - according to its characteristics.
Dimence, Centre for Developmental Disorders, Zwolle, The
Results.– Among the respondents with acute nonspecific pain, the
Netherlands
mental/physical labor distribution in the group was 12/18,the pain
Background and aims.– According to a proposal for a new definition
intensity was 4.9 ± 1.3 points in the VAS, the duration of the disease
of health (Huber et al., 2011), health is not as the WHO definition
was 13.9 ± 3.8 days, the sleep disturbance was 58.8%. In the group
still stipulates absence of disease and a state of complete men-
of chronic nonspecific pain, there were also more intellectuals (21
tal, physical and social wellbeing, but the capacity to adapt under
patients). The intensity of pain was 4.3 ± 0.8, and the duration of
different circumstances, including the burden of disease.
the disease was 9.5 ± 1.4 months. Sleep was disturbed in 92.8%.
Aim. –Life and the burden of disease is considered in relation to
Correlation analysis to assess the association of sleep disorders
gender. The question is whether women are more vulnerable to
with age revealed a negative correlation in both groups (p = −0.386
ill/health for a series of gender/bound reasons.
(p = 0.035) for acute and p = −0.594 (p = 0.001) for chronic pain).
Methods.– The scientific literature was searched and questioned
Similar characteristics were related to the duration of pain and
on various relevant issues: What is the role of gender in
sleep disorders (p = −0.318 (p = 0.043) for acute and p = −0.613
gene-environment interactions? Are there gender related neurobi-
(p = 0.004) for chronic pain),pain intensity and sleep disturbances
ological differences in the development of stress regulation? What
(p = −0.273 (p = 0.040)) for acute and p = −0.355 (p = 0.012) for
is the role of childrearing and of social/economic circumstances?
chronic pain),mental labor and sleep disorders in cases of chronic
Results.– Gender is an essential intermediate factor between genetic
pain syndrome (p = −0.542 (p = 0.006).
predisposition that influences brain and psychological develop-
Conclusions.– A direct relationship was established between the
ment leading to behaviours and coping mechanisms that are
duration of pain syndrome and the intensity of pain in patients
different across sexes. Stress regulation is different in men as com-
with nonspecific low back pain. The frequency of sleep disorders
pared to women. The much shorter but far more intense reaction
increases with the age of patients and in persons of mental labor
of the hypothalamus-pituitary-adrenergic system in women has
impact on immune-reactions but especially on vulnerability for
interest statement.
psychopathology. This tendency appears to have been strength-
ened by the different ways of childrearing.
E-PP1219 Conclusions.– There are both neurobiological but also environmen-
tal (child rearing) differences in the physiology of stress response
What are the differences in sleep skills between women and men. Under the same circumstances men will
between insomnia patients with and react with a higher vulnerability to infections, cardio-vascular and
without need of hypnotics? metabolic disorders. Women are more prone to react with depres-
H.R. Song sion and anxiety and develop autoimmune diseases.
Myongji Hospital, Psychiatry, Goyang-si, Republic of Korea Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– We checked ordinary sleep skills of insomnia interest statement.
patients and changes of sleep skills after sleep cognitive behav-
ioral therapy (CBT), and evaluated the difference in changes of sleep
skills between patients with and without need of hypnotics.
Methods.– A total 131 patients’ sleep disturbance was assessed by
visual analogue scales (VAS). Patients received 9 sessions of CBT
focused on the Limit the amount of time spent in bed and main-
tain a regular sleep/wake cycle (SH1), Get regular exercise (SH2),
E-PP1221 The survey consisted of a socio-demographic questionnaire and the

Quality of life, perceived stress Sleep Paralysis Experiences and Phenomenology Questionnaire.
Results.– Prevalence rates of SP was high: 33.1% of participants
severity and depressive symptoms in
reported at least one episode of SP in their lifetime (32.3% female,
sleep bruxism 36.6% male). Of those who reported at least one lifetime episode,
J. Smardz1 , H. Martynowicz2 , T. Wieczorek3* , M. Michałek2 , R. 29.5% had experienced four or more episodes during the previous
˛ 2 , A. Wojakowska2 , G. Mazur2 , M. Wieckiewicz
Poreba ˛ 1
year. A total of 64.0% reported hypnopompic or hypnagogic hallu-
1 Wroclaw Medical University, Department of Experimental
cinations (visual hallucinations were the most common: 44.0%). A
Dentistry, Wrocław, Poland; 2 Wroclaw Medical University, total of 94.7% complained about somatic symptoms during SP (most
Department of Internal Medicine, Occupational Diseases and commonly a rapid heartbeat: 72.5%), 96.6% felt fear and 41.8% fear
Hypertension, Wrocław, Poland; 3 Wroclaw Medical University, of death.
Department of Psychiatry, Wrocław, Poland Conclusions.– The prevalence of SP among university students in
Poland was higher than Ireland (33.1% vs. 19.9%). Results of this
study were in keeping with cross-cultural research, indicating that
Background and aims.– Sleep bruxism (SB) is a relatively common
SP among university students is associated with hallucinations,
phenomenon in adults (13% ± 3% of general population) and affects
somatic symptoms and fear.
mostly patients aged 20–40. It is characterized by presence of regu-
lar or frequent tooth grinding sounds occurring during sleep, which
interest statement.
lead to abnormal tooth wear or other symptoms (e.g. masticatory
muscle pain). The aim of this study was to assess quality of life (QoL),
depressive symptoms and perceived stress severity in patients with
E-PP1223
SB.
Methods.– 71 adults (mean age = 34,5 ± 10,6) with SB and no other Relapse prevention with depot
important medical conditions underwent video-polysomnography antagonist preparations after tapering
(v-PSG) in order to confirm diagnosis. They were evaluated with of substitution therapy in oud
battery of tests, including Perceived Stress Scale-10 (PSS-10), WHO J. Singh1* , D. Kaur2
Quality of Life BREF questionnaire (WHOQOL-BREF) and Beck 1 Amrit Foundation, Drug De-Addiction, Amritsar, India; 2 Sgimsar,
Depression Inventory (BDI). Physiology, Amritsar, India
Results.– In PSG evaluation moderate SB was diagnosed in n = 24 * Corresponding author.
(33,8%) and severe SB in n = 30 (42,25%) participants. In the SB group

n = 16 (29%) patients had positive score in BDI and n = 26 (48,15%) Background and aims.– Medication Assisted Treatment with Substi-
scored positively in PSS-10. No significant differences in BDI and tution Therapy in form of Buprenorphine or Methadone is proven
PSS-10 scores have been observed between SB and healthy group. to be safe and effective in reducing the mortality and morbidity
QoL in somatic and psychic domains was significantly lower in associated with Opioid Use Disorders. However, some patients sta-
groups with positive PSS-10 (p < 0,01) and BDI (p < 0,0001). Other ble with Buprenorphine want to stop buprenorphine after a period
factors contributing to lower QoL were identified. of time due to different reasons.
Conclusions.– Development of different psychiatric and somatic Methods.– We report a series of 46 patients in which we tapered
symptoms in course of SB suggests that interdisciplinary approach, buprenorphine. After stopping buprenorphine in first group of 22
including mental healthcare, may be required in SB management. patients only comfort medicines were given and second group of
As psychosomatic background of this disorder is still not confirmed, 24 patients were given monthly I/M depot naltrexone injections
we suggest that psychiatric symptoms may contribute to SB as well along with comfort medicines. All the patients in both the group
as result from it, what is typical for most psychosomatic disorders. were psycho-socially stable at-least six months before stopping
Disclosure of interest.– The authors have not supplied a conflict of buprenorphine. In all the patients a gradual detox from buprenor-
interest statement. phine was done in 7–10 days.
Results.– In first group after three months 12 patients tested neg-
ative for illicit Opioid in urine, 2 patients went out of country
E-PP1222 permanently, 2 patients were untraceable and 6 had relapsed back
Sleep paralysis in sample of Polish to Opioid use. After six months 7 patients tested negative to urine
university students: prevalence rates Opioids (33%), 4 were untraceable and 9 had relapsed back to Opioid
use. In second group after 3 months 17 patients tested negative for
and characteristics
Opioid, 2 were untraceable and 5 had relapsed. After 6 months 14
P. Wróbel-Knybel1* , M. Flis1 , J. Rog1 , B. Jalal2 , H.
I/M Depot Naltrexone injected patients tested negative for Opioid
Karakuła-Juchnowicz1
1 Medical University of Lublin, I Department of Psychiatry, (59%), 3 were untraceable and 7 had relapsed.
Conclusions.– long acting preparation of opioid antagonists are safe
Psychotherapy and Early Intervention, Lublin, Poland; 2 University of
and effective method to reduce the incidence of relapse after stop-
Cambridge, Behavioural and Clinical Neuroscience Institute and
ping substitution therapy .
Department of Psychiatry, Cambridge, United Kingdom
interest statement.
Background and aims.– Sleep paralysis (SP) is a phenomenon asso-
ciated with disruption of rapid-eye movement (REM) sleep. The
prevalence of SP among university students is estimated to be E-PP1224
between 5.3% to 55.8%. Only one study in Europe to our knowl- E-designer drugs - novel psychoactive
edge has assessed the prevalence of SP among student populations,
substances in liquids for e-cigarettes
namely in Ireland.
R. Skowronek1* , M. Majchrzak2 , R. Celiński2
The aim of this study was to determine: (1) prevalence rates of SP 1 Medical University of Silesia in Katowice, Department of Forensic
and (2) psychological and somatic symptoms accompanying SP in
Medicine and Forensic Toxicology, Katowice, Poland; 2 Toxicological
a Polish sample of university students.
Laboratory ToxLab, Toxicological Laboratory ToxLab, Katowice,
Methods.– The current sample consisted of 2598 students (2073
Poland
female, 525 male) recruited from a number of Polish Universities. A * Corresponding author.
web-based, survey style approach was utilized in the present study.
Background and aims.– Classic e-liquids for vaporizers and e- remission period, is reliable for validity and reproduction in addic-
cigarettes contain nicotine in a propylene glycol solution. A new tology.
phenomenon on the drug market is the intentional addition of novel Disclosure of interest.– The authors have not supplied a conflict of
psychoactive substances to liquids for e-cigarettes. Our objective is interest statement.
drawing attention to a new health problem, so called drug vaping.
Methods.– Analysis of two cases from the expert practice of the
authors, one with survival of the victim, and one lethal. E-PP1226
Results.– In the first case, the father of a 17-year-old girl has Method of treatment of alcohol (beer)
provided to the toxicological analysis e-cigarettes with the con- dependent patients
tent of viscous liquid that she used. After burning, she began to I. Sosin* , Y. Chuiev, O. Honcharova
behave strangely and experienced epileptic seizures. In the ana- Kharkiv Medical Academy of Postgraduate Education, Department of
lyzed sample from evidence material, the presence of a substance Narcology, Kharkiv, Ukraine
characterized by a pseudomolecular ion with a value of m/z = 375 * Corresponding author.
and the retention time corresponding to the furanylfentanyl (an
opioid analgesic, also known as Fu-F) pattern was demonstrated. Background and aims.–
In the second case, an adult man was supposed to smoke an e- Introduction.– Predominant type of the abused alcoholic beverage
cigarette, to which he added cannabinols, before his death. In determines specific intoxication and addiction clinical structure. It
the analyzed blood sample the presence of a substance charac- is notably relevant considering the present-day beer dependence,
terized by a pseudomolecular ion with a value of m/z = 378 and a with well-known clinical and psychopathological features trans-
retention time consistent with the standard of 5F-ADB (an indazole- formed significantly due to beer hypervolemia, disordered kidneys,
based synthetic cannabinoid, also known as 5F-MDMB-PINACA) cardiovascular, liver, pancreas, brain, detoxification physiological
was demonstrated. Additionally, in the analyzed urine sample two systems, etc.
metabolites of 5F-ADB have been found. Objectives.– Innovation improving effectiveness of method for alco-
Conclusions.– The use of electronic vaping devices for recreational hol (beer) dependence therapy.
drug and new psychoactive substance (NPS) administration is a real Methods.– Components for new pharmacological complex were
new danger for health and even live of abusers. searched by analytical screening of pharmacotherapeutic prop-
Disclosure of interest.– The authors have not supplied a conflict of erties of drugs, and recommended principles, considering beer
interest statement. dependence characteristics: 1) beer hypervolemic status; 2) con-
traindicated intravenous administration of plasma substitutes; 3)
polymorphic intoxication factor; 4) beer lesions of vital organs and
E-PP1225 systems; 5) possibility to use Colme (Cianamid, Spain) – effective
Method of integrated prediction of anti-alcohol sensitization agent, which is positively different com-
relapses in alcohol addiction pared to the complications and side effects of Disulfiram.
I. Sosin* , Y. Chuiev, O. Honcharova Results.– The developed method for treating alcoholic beer depen-
1 Kharkiv Medical Academy of Postgraduate Education, Department dence (Patent 8518, UA), tested in 46 patients, includes preventive
of Narcology, Kharkiv, Ukraine use of conventional detoxification therapy, and tetrad pharmaco-
* Corresponding author. logical complex: hepatoprotector Antral 0.2 g three times a day,
for 21–30 day course; diuretic Trifas (Torasemide), a quarter/half
Background and aims.– pill once per day, for 2–3 days; oral enterosorbent Atoxil (Silicium
Introduction.– Current addictology science and clinical practice dioxide) daily 12 g, dissolved in 250 ml of water, divided into 3–4
regard an effective way to improve treatment for alcohol depen- meals per day, for 3–5 day course; sensitizer Colme (Cianamid)
dence (AD), which is based on evolution of conceptual framework 36–75 mg (12–25 drops of standard solution), twice daily, for 3–4
of clinical polymorphism of remission states and relapse dangerous week course; against the background of psychotherapeutic poten-
clinical situations (RDCS), their timely clinical diagnosis for preven- tiation, mediation and suggestion.
tive, targeted, relieving anti-relapse therapeutic interventions. To Conclusions.– An original complex of valid pharmacological tetrad
objectify RDCS, present-day addictology, psychiatry, pathopsychol- was proposed, which significantly increases differentiation and
ogy avail of large range of modalities for interviewing, tests, scales, effectiveness of therapy for beer addiction.
questionnaires, etc. Disclosure of interest.– The authors have not supplied a conflict of
Objectives.– To develop a new, original way of integrative prediction interest statement.
of AD relapses.
Methods.– MADRS, HADS, Hamilton, Spielberger–Khanin scales,
clinician’s global impression (CGI), Quality of life (QoL) indicator E-PP1227
international test, tremor laser diagnosis (patent 29650, UA). Tobacco dependence with an extreme
Results.– Method for integrated diagnosis of alcohol dependence number of cigarettes smoked: clinical
relapses possibility (Patent 79063, UA), which contains identify-
and genetic study
ing of specific AD symptomatic and syndromology signs, namely:
O. Speranskaya
pseudowithdrawal syndrome, subject dreams, asthenic irritability,
Federal Medical Research Center of Psychiatry and Addiction,
depressive and dysphoric manifestations, anxiety, dissomnic disor-
Ministry of Health Care, Russia, Tobacco Dependence Department,
ders, pathological craving for alcohol, etc., and additional targeted
Moscow, Russia
test monitoring of general psychological QoL indicators, and latent
Background and aims.– The aim of the study was to find out if the
tremor laser diagnosis, was developed. Evidence of one and more
extreme number of cigarettes smoked per day by the patients with
RDCS in the patient: QoL total reduction to 73.0 and less; three
tobacco dependence corresponds with their clinico-genetic char-
QoL scales (“physical well-being”, “psychological well-being” and
acteristics.
“general perception of the quality of life”) total reduction to level
Methods.– Clinical and genetic study was conducted in 50 patients
22 or less; latent or evident tremor diagnosed by laser screening –
with high level of tobacco dependence (K. Fagerstroem). Patients
diagnose the possibility of remission failure, the alcohol relapse.
were of similar age and duration of current tobacco dependence.
Conclusions.– The proposed method of prediction of AD relapse,
The main group (n = 24) with an extreme number of cigarettes/day
tested on a large population of alcohol dependent individuals in
(47 ± 5,1). the control group (n = 26) - 25.2 ± 2,6 cigarettes/day.
The patients of the main group had the history of pharmacological E-PP1229
resistance to antinicotinic drugs (Varenicline, Nicorette, Citizine). Screening subjects on buprenorphine
In the control group each ofthe patients had several affective quit
maintenance treatment for
attempts.
The genetic study included identification of polymorphism (vari-
problematic alcohol use with self
ations) of the gene nicotinic receptor rs578776 and COMT gene report and carbohydrate deficient
rs4680 in all the patients. transferrin (CDT)
Results.– The main symptom of tobacco dependence - craving for S. Thapaliya
tobacco - was of maximum level-3, 75 ± 0, 96 balls (of 4 balls maxi- National Medical College, Psychiatry, Birganj, Nepal
mum) in the main group, medium level - 1,67 ± 0,083 balls – in the Background and aims.– Opioid dependent subjects on Buprenor-
control. phine maintenance treatment (BMT) are known to use alcohol
The presence of alexithymia (score of ≥68 Toronto Alexithymics in problematic pattern but frequently tend to under-report the
Test) was revealed in 95.8% patients of the main group and in 11.54% current pattern. The study aimed to screen individuals on BMT
of the controls (p < 0.001) for problematic alcohol use by employing Alcohol, Smoking and
The homozygosity for valine in the main group was 91,6%, in the Substance Involvement Screening Test (ASSIST) questionnaire and
control 7,7% -(X2 = 5,78, p = 0,0109). Carbohydrate Deficient Transferrins (CDT) test.
For rs578776 polymorphism of ɑльфɑ3 subunit of nicotinic choli- Methods.– A total of 89 participants on Buprenorphine mainte-
noreceptor: the main group - 87,5% of the patients, the control - nance treatment were screened for alcohol use with WHO ASSIST
11,5%. questionnaire and serum CDT levels (ELISA) were analysed. The
Conclusions.– The differences in genetics backgrounds, clinical fea- participants were categorized into two groups of alcohol users:
tures and emotional-personal properties of persons with “normally Moderate Risk/High Risk corresponding (ASSIST score >11) and Low
hard” and “extreme” tobacco addiction demand the individualized Risk (ASSIST score < 11). The CDT level cut offs were defined as nor-
therapy approaches. mal alcohol use (<60 mg/l), probable alcohol use (60–100 mg/l) and
Disclosure of interest.– The authors have not supplied a conflict of high probable alcohol use (>100 mg/l).
interest statement. Results.– Among the participants, 28.3% were consuming alcohol in
moderate to high risk severity based on WHO ASSIST score. Inter-
estingly, 82% participants had elevated serum CDT levels (>60 mg/l)
E-PP1228 with more number of individuals in Moderate/high risk severity
Why do adult people whose parents (ASSIST>11) compared to Low Risk (ASSIST score < 11) (i.e. 90.7%
were alcohol addicts feel guilty vs. 73.9%). Furthermore, more percentage of Moderate /High Risk
A. Spivakovskaya, A. Lutsenko* alcohol users had serum CDT levels in the range of high Probable
Moscow State University, Faculty of Psychology, Moscow, Russia alcohol use (i.e. CDT levels >100 mg/l) compared to Low Risk alcohol
* Corresponding author. users (32.6% vs. 17.4%). Overall, CDT values were higher in Moder-
ate/High risk group compared to Low Risk group, without reaching
Background and aims.– In Russian Federation there are over 12 mil- statistical significance (p>0.05).
lion families, where parents have alcohol addiction. Toney A. in the Conclusions.– Combining CDT and ASSIST can be useful technique to
12-step recovery program for adults whose parents were alcohol recognize problematic alcohol users maintained on Buprenorphine
addicts wrote, that these people usually feel guilty because their maintenance treatment, requiring further exploration.
parents did not take care of them. Most of the research on this topic Disclosure of interest.– The authors have not supplied a conflict of
was conducted either on mentally ill people, or on individuals who interest statement.
suffered from alcohol or other addictions.
Objectives.– To study the feelings of guilt and shame experienced
by adult people whose parents were alcohol addicts. E-PP1230
Methods.– The sample: experimental group (n = 50) consisted of Epidemiological situation of
mentally healthy adults who did not suffer from addictions but substance related disorders in under
whose parents were alcohol addicts and 50 controls. We used:
20 years old patients in Russia
1) guilt questionnaires (“The Interpersonal Guilt Questionnaire”,
E. Tiuliandina
“The Guilt Inventory Questionnaire”, 2) a lot of qualitative meth-
I.M. Sechenov First Moscow State Medical University, Public Health
ods (analysis of Thematic Apperception Test, a phenomenological
and Health Care Organization Department, Moscow, Russia
analysis of the transcripts of the public meetings 12-step recovery
Background and aims.– To find out actual epidemiological data of
program, phenomenological analysis of interviews).
substance related disorders in under 20 years old patients in Russia.
Results.– Guilt experienced by adults whose parents had alcohol
Methods.– Epidemiological data of both sexes patients under 20
addiction scored significantly higher than the feelings of guilt in
years old of 2016 from The Institute for Health Metrics and Eval-
control group (p = 0,038).
uation (IHME) base has been analyzed. We used such parameters
Conclusions.– Adults whose parents were alcohol addicts felt guilty
as incidence, deaths, years lived with disability (YLDs), disability-
in situations when they took care of somebody and did not know
adjusted life years (DALYs) in young patients, who live in Russia.
how to do this because their parents did not take care of them.
Results.– In Russia in 2016 there were 13.59 new cases of cocaine
The participants of the experimental group were also inclined to
use disorders, 20.3 of amphetamine use disorders, 26.13 of opi-
experience guilt as a taboo offense against the parents, the guilt in
oid use disorders, 69.61 of cannabis use disorders per 100,000.
the experience of the death of close relatives.
0.027 deaths per 100,000 in cocaine use disorders, 0.0619 deaths in
amphetamine use disorders, 0.53 deaths per 100,000 in opioid use
interest statement.
disorders have been registered. Years Lived with Disability (YLDs):
in cannabis use disorders 6.3 YLDs per 100,000, in cocaine use dis-
orders 6.49 YLDs per 100,000, in amphetamine use disorders 9.36
YLDs per 100,000, in opioid use disorders 19.14 YLDs per 100,000.
Disability-adjusted life years (DALYs): in cannabis use disorders
6.3 DALYs per 100,000, in cocaine use disorders 8.36 DALYs per
100,000, in amphetamine use disorders 10.69 DALYs per 100,000, ual, including the ability to have a premonition pertaining to the
in opioid use disorders 55.66 DALYs per 100,000. consequences of alcohol addiction. The purpose of research is to
Conclusions.– In Russia is still the high risk both of the incidence determine the level of anticipatory skills of individuals addicted to
and mortality from substance related disorders in under 20 years alcohol and to find a connection between the anticipatory skills and
old patients. The use of such substances as amphetamine or opi- the intellectual skills.
oids increases in several times the probability of disability in these Methods.– The survey covered 40 alcohol-addicted individuals and
young patients. 60 non-addicted persons at age from 20 to 30. We used the follow-
Disclosure of interest.– The authors have not supplied a conflict of ing tests: questionnaire to reveal early symptoms of alcoholism, V.
interest statement. Mendelevich anticipatory consistency test, L. Regush diagnostics of
the ability to predict, the R. Amthauer intelligence structure test.
Results.– The research has shown that alcohol-addicted individu-
E-PP1231 als have much lower intellectual levels than non-addicted persons.
Trajectories of the use of substances Alcohol-addicted individuals have much lower anticipation abili-
in the transition from the adolescent ties such as common anticipation abilities, personal anticipation
abilities, and time anticipation abilities, which are related to their
mental health center to the adults
intellectual skills. An ability to anticipate are connected with
mental health center; a descriptive common intellectual level and some subtests of R. Amthauer
study intelligence structure test, such as ‘arithmetical tasks’, ‘spatial
A. Trabsa Biskri* , E. Mur, S.T. Castillo, L. Ayllon, X. Lara, J. Moreno, imagination’, ‘spatial generalization’, ‘memory’. It has also been
S. Oller proven that the low anticipation level of an individual influences
1-Institut Hospital del Mar D’investigacions Mèdiques, IMIM, Parc de his intellectual abilities such as control of pronunciation, appropri-
Salut Mar, Psychiatry, Barcelona, Spain ate verbal expressions, memorizing skills, retaining and displaying
incentives.
Conclusions.– Taking into account the results obtained during
research, it can be concluded that alcohol addiction affects the
Introduccion.– The use of psychoactive substances (PS) remains one
intellectual development of an individual and the level of his antic-
of the greatest public health concerns in the world with significant
ipatory skills.
costs for society. For most young people, experimentation with psy-
choactive substances during adolescence is transitory. However, it
interest statement.
can lead to social and medical problems that can be maintained
during the adulthood.
Objectives.– The aim of this study is to describe the evolution of the E-PP1233
use of substances in the transition from adolescence to adulthood
Early cannabis use and its relationship
in a group of patients that come from the Adolescent Mental Health
Center to Adults Mental Health Center. to fetal developmental outcomes and
Methods.– A total of n = 41 patients that came from Adolescence psychiatric disorders
Mental Health Center were registered between 2015–2017 in I. Valriberas* , R. de la Mata, A. Ojeda, N. Casado, J. de la Iglesia, R.
“Martí i Julià Adults Mental health Center”. PS use was assessed. de Alarcon, C. Roncero
The information included in the database was completed with elec- Hospital Clinico Universitario de Salamanca, Mental Healh
tronic medical reports. Cross-sectional descriptive analysis was Department, Salamanca, Spain
performed using software “IBM SPSS Statistics (Chicago INC)”.
Results.– From a total of 41 patients, 9 used PS during adolescence.
Background and aims.– The prevalence of cannabis use in pregnant
Only 1patient discontinue the use during adulthood. From the non-
women, perceived availability, perception of risk and the relation
PS-users during adolescence, 4 become PS users in adulthood. From
between prenatal exposure to cannabis with developmental disor-
the total PS users in adulthood, 66,7% had family problems and
91,7% had school problems. ders and mental disorders are described.
Systematic review of the literature on cannabis use in pregnant
Conclusions.– CONCLUSIONSMost of patients who initiate PS use
women. To evaluate the potential effects of pre-natal cannabis
during adolescence maintain using PS in their adulthood. These
exposure on fetal development and on the mental health of exposed
patients have a vulnerable socio-familiar situation. It is important
children
to prospectively study these patients in order to make early inter-
Methods.– Systematic review of Spanish epidemiological studies of
ventions to reduce the damage related to the use of psychoactive
the National Plan on Drugs and studies on maternal use of cannabis
substances.
and the relation between early exposure to cannabis and psychi-
atric disorders in exposed children, published in PubMed database
interest statement.
until July 2018 in English, using the keywords
Marijuana, Cannabinoids, Mental disorders, Pregnancy, Prenatal
E-PP1232 Cannabis Exposure, Risk factors. Selection of studies: 114 poten-
tially eligible articles for the review. Finally, 60 articles were
Low anticipatory abilities in alcohol
included:4 focused on the prevalence of prenatal exposure to
abused individuals cannabis, 7 on methods of screening consumption in pregnant
L. Kartifuzova1 , O. Dolgova1 , T. Vasheka1 , S. Tukaiev2* women, 33 on the relation between exposure to cannabis and
1 National Aviation University of Kyiv, Aviation Psychology developmental and / or psychopathological sequelae, 9 molecular
Department, Kiev, Ukraine; 2 National Taras Shevchenko University studies and 7 studies in rodents.
of Kyiv, Department of Physiology of Brain and Psychophysiology, Results.– Cannabis use in pregnant women is frequent but little
Kiev, Ukraine studied, prenatal exposure to cannabis has been linked to affective
sympthoms and Attention Deficit Hyperactivity Disorder (ADHD).
Background and aims.– The human behavior depends on the individ- Conclusions.– It is important that mental health professionals, who
ual’s ability to anticipate the future. It is presumed that alcoholism assist women of childbearing age, can explain the relation between
significantly affects the cognitive processes of an addicted individ- prenatal exposure to cannabis and developmental/mental health
disorders on exposed children.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The overall prevalence of lifetime khat use was 59.9%, and
interest statement. the prevalence of khat abuse among psychopathy prisoners was
78%. The result showed that, participants with psychopathy had 3
times increased odds of having khat abuse compared to their coun-
E-PP1234 terparts (AOR = 3.00 (1.17–7.67)). Among the confounders, those
Trauma exposure and alcohol use who had family history of use substance, poor support, alcohol
disorder among prisoners in jimma use disorder and suicidal ideation and attempt were also positively
associated with khat abuse.
zone correctional institution,
Conclusions.– The prevalence of khat abuse was high among pris-
Southwest Ethiopia oners with psychopathy. This study indicates that prisoners with
Y. Yitayih psychopathy are at higher risk for khat abuse than those with no
Jimma University, Psychiatry, Jimma, Ethiopia psychopathy.
Background and aims.– Trauma exposure and alcohol use are closely Disclosure of interest.– The authors have not supplied a conflict of
related, and a large proportion of trauma-exposed individuals use interest statement.
alcohol. However, little is known about the association between
trauma exposure and alcohol use disorder among prisoners in
Ethiopia. Therefore, we examined alcohol use disorder in inmates E-PP1236
of Jimma Zone correctional institution, Southwest Ethiopia, who Supporting the change of addictive
had traumatic life experiences.
Methods.– We employed a cross-sectional study design to collect
behaviors: a group motivational
data from 336 prisoners from June 5 to July 5, 2017. Alcohol Use approach
Disorders Identification Test, Life Events Checklist, Fagerstrom Test R. Zaouche* , B. Tesson, F. Bossis
for Nicotine Dependence, Drug Abuse Screening Test, Psychopathy EPSM Vendée, Day Hospital of Addictology, La Roche Sur Yon, France
Checklist Screening Version and Oslo 3-Item were used. Data were
entered into EpiData version 3.1 and analyzed in logistic regression
Background and aims.– Changing an addictive behavior is a long pro-
models. Variables with a P value < 0.05 in the final fitted model were
cess requiring a huge psychic energy called motivation. To make
declared to be significantly associated with the outcome variable.
this energy emerge, motivational groups are an effective therapeu-
Results.– The prevalence of lifetime alcohol use was 40.1%, and
tic tool.
prevalence of alcohol use disorder among prisoners with lifetime
Our objective is to present a model of motivational group work
trauma exposure was 44.0%. The result showed that, participants
aiming to promote the change of addictive behaviors.
with multiple trauma exposures had 2.5 times increased odds
Methods.– We followed the work steps of patients engaged in a
of having alcohol use disorder compared to their counterparts
weekly motivational and open group, on a 5-week cycle at the
(AOR = 2.47 (1.23–4.94)). Among the confounders, those living in
Addictology Day Hospital of the Public Establishment of Mental
urban areas, presence of psychopathy, khat abuse, and nicotine
Health of Vendée, from February to March 2018.
dependence were also positively associated with alcohol use dis-
Results.– The number of patients varies from 8 to 12 in each session,
order.
depending on absences, withdrawals and new admissions. Patients
Conclusions.– The prevalence of alcohol use disorder was high
are at different stages of change according to the Prochaska and
among prisoners with lifetime exposure to traumatic life expe-
Di Clemente model and suffer from substance and / or behavioral
rience. This study indicates that prisoners with multiple trauma
addictions. Each session lasts one hour and is co-animated by an
exposures are at higher risk for alcohol use disorder than those
addictologist and a caregiver. During the first session (11 patients)
with no trauma exposure.
we tried to explore and resolve the ambivalence by demonstrat-
ing the physical effects of addictive behaviors. The second session
interest statement.
(8 patients) aimed to highlight the values of each patient, then to
complete the decisional balance. In the third (9 patients) and fourth
E-PP1235 week (12 patients), we worked on builduing self-esteem and iden-
tifying the skills of each patient. In the last session (8 patients)
Psychopathy and khat abuse among we summarized everyone’s progress and promoted exchanges
prisoners in Jimma correctional between patients in order to pool their experiences and their reflec-
institution tions.
Y. Yitayih Conclusions.– The group approach, very valuable in addictology,
Jimma University, Psychiatry, Jimma, Ethiopia allows to empower the motivational interviwing and strengthen
Background and aims.– Psychopathic features lead to increases in its effectiveness in the management of addicted patients.
substance use because of facets of personality linked to features of Disclosure of interest.– The authors have not supplied a conflict of
psychopathy. However, little is known about association between interest statement.
psychopathy and khat abuse among prisoners in Ethiopia. There-
fore, we examined relationship between psychopathy and khat
abuse among prisoners in Jimma correctional institution, South- E-PP1237
west Ethiopia. Mixed methods to explore factors
Methods.– We employed a cross-sectional study design to col- associated with the decline of patients
lect data from 336 prisoners from June 5 to July 5, 2017. Study
participants were selected by a systematic random sampling tech-
in the methadone maintenance
nique. Khat abuse was assessed by drug abuse screening tool and treatment program in Shanghai, China
psychopathy was assessed by Psychopathy Checklist Screening L. Zhang* , J. Bao, M. Zhao, J. Du
Version. We also assessed nicotine dependence, alcohol use disor- Shanghai Mental Health Center, Shanghai Jiao Tong University School
der, adverse traumatic life events and Social Support Scale. Data of Medicine, Department of Substance Abuse and Addiction,
were entered into EpiData version 3.1 and analyzed in logistic Shanghai, China
regression models. Variables with a P value < 0.05 in the final fit-
ted model were declared to be significantly associated with the
outcome variable.
Background and aims.– This study was to characterize the 1). According to WHO data, in the last years, suicide has become
methadone maintenance treatment (MMT) in Shanghai, China, and Europe’s leading cause of violent death among young people, even
to explore factors associated with the decline of patients in MMT above traffic accidents.
during 2005–2016. Conclusions.– Suicide data are in many cases controversial due to
Methods.– Both qualitative and quantitative methods were used in the taboo that still exists on this phenomenon and the difficult clas-
this study. Based on the data from Shanghai Centers for Disease sification and definition of a multifactorial and complex behavior.
Control (CDC), we described the changes in the number of patients Disclosure of interest.– The authors have not supplied a conflict of
who received MMT, and new enrollment each year from 2005 to interest statement.
2016. Focus groups were conducted with 22 patients, and in-depth
interviews were conducted with 9 service providers.
Results.– Quantitative data demonstrate that the number of new E-PP1239
enrollment began to decline in 2009, and the number of patients Tunisian general practitioners facing
receiving MMT began to decline in 2012. The main reasons for attempted suicide
dropout include: (1) discontinuing medication due to unknown I. Baati1* , I. Triki1 , K. Yaich1 , J. Jdidi2 , S. Ellouze1 , R. Sellami1 , M.
reasons (25%); (2) criminal activities other than drug-related crimes Moalla1 , I. Feki1 , J. Masmoudi1
(20%); (3) relapse to heroin use (16%); (4) physical disease (10%). 1 Hedi Chaker University Hospital, Sfax, Tunisia, Psychiatry “A”, Sfax,
Qualitative assessment results indicate that the major reasons for Tunisia; 2 Hedi Chaker University Hospital, Sfax, Tunisia, Department
the decline of patients in MMT are as follows: (1) the increase of of Community Health and Epidemiology, Sfax, Tunisia
Amphetamine-type stimulants (ATS) use in recent years; (2) lim- * Corresponding author.
ited knowledge about MMT in both patients and MMT staff; (3)
complicated enrollment criteria; (4) discrimination against drug Background and aims.– To evaluate the knowledge, attitude and
use. practice of Tunisian general practitioners (GPs) after a suicide
Conclusions.– Various reasons to explain the decline of patients in attempt.
MMT in Shanghai, China were identified. Government agencies, ser- Methods.– A cross-sectional, descriptive and analytic survey was
vice providers and other stakeholders need to work together and carried out during three months (from September 16 to November
overcome identified barriers to support MMT programs in China. 27, 2017).
Disclosure of interest.– The authors have not supplied a conflict of Among 126 GPs randomly selected, 103 participated to the study.
interest statement. Results.– Fifty-nine of our participants were men (57.3%). The aver-
age age was 49.65 ± 8.18 years. Thirty-six of GPs had a training
about suicide. Nearly half of the GPs interviewed (47.6%) com-
pleted an internship in a psychiatric department. As for theoretical
E-Poster Presentation: Suicidology and suicide knowledge about suicide, the proportion of correct answers was
prevention - Part I 75.5% overall participants. The score of correct answers was cor-
related to the fact of having continuing medical education about
suicide (p = 0.022). The most reported emotions by GPs in front of an
E-PP1238 attempted suicide were sadness (35.9%), pity (32%) and fear (32%).
Among our participants, only 74 were in contact with a patient
Suicide, the new big pandemic? an
with attempted suicide. The majority of GPs preferred to refer such
approximation to the real world a patient, without or with a psychiatric history, to a specialist or
suicide data an emergency department (67/74 and 62/74, respectively). Only
Í. Alberdi-Páramo* , G. Montero Hernández, M. Pérez Lombardo, 12.3% said they were satisfied with their management of suicide
J.E. Ibañez Vizoso, J. Pemán Rodríguez, J. Gómez Beteta, M. attempts.
Villanueva Gallego, M.D.C. Ruíz Galindo, L. Pérez Luna, A. Bermejo, Conclusions.– Our results showed that the GPs knowledge about
M. Jiménez, B. Rodado, A. García Carpintero, V. Pérez Navarro, M. suicide was correlated to the fact of having continuing medical
Sánchez Amores, M.D. Sáiz González education. Yet, an improvement of educational activities for the
Clinico San Carlos Hospital, Psychiatry, Madrid, Spain management of suicide attempt is needed to help GPs to control
their emotions and enhance their practice.
Background and aims.– Suicide is an important health problem that
interest statement.
causes 800,000 deaths/year in the world. It is an important cause of
morbidity too, with little medical attention. For mental health pro-
fessionals, suicidal behavior is a nuclear issue. It has a transversal E-PP1240
association with several diseases, mainly depression. And we have
a need to establish effective prevention strategies because of the
“To end or not to end, is the
devastating results. question. . .!”: content analysis of
Objectives.– To show the real world suicide data in the world and suicide notes and thematic analysis of
in Europe. interviews, a qualitative study in
Methods.– We have reviewed the data of the World Health Associ- suicide survivors
ation, Eurostat and we have done a systematic review in PubMed. D. Banerjee
Results.– For every suicide, there are many more suicide attempts National Institute of Mental Health and Neurosciences, Psychiatry,
every year. Among the general population, a suicide attempt is the Bangalore, India
single most important risk factor. Suicide is the second leading Background and aims.– India stands out as the ‘suicide-capital of
cause of death in the 15–29 age group. 78% of all suicides occur South-east Asia’ with increasing suicide rates every year. Elderly
in low and middle income countries. Pesticides ingestion, hanging population is twice more likely to act out on their suicidal ideations
and firearms are some of the most common methods of suicide in with multiple other vulnerabilities. We attempted to understand
the world. By country, the highest rates worldwide are found in the the perceptions of suicide survivors.
ex-Soviet countries (Lithuania, Russia, Slovenia, Hungary) and East- Methods.– Between 2014 to 2016, all elderly (age > 60 years) who
ern countries (South Korea and Japan). Brazil, Mexico, Colombia, attempted suicide in our institute by any means (not just self-
Greece, Turkey and South Africa have the lowest rates (Figure harm) with an intention of dying, but survived the attempt, were
enrolled with consent (M:40, F:11). Their suicide notes (if present) E-PP1242
were obtained with permission and in-depth one-to-one inter- Estimation of future suicide risk in
views were conducted with them once they were medically and
psychiatric inpatients with a 6-item
psychiatrically stable. Thematic analysis of the interviews and con-
tent analysis of the suicide notes were done, based on Charmaz’s
questionnarie
grounded theory approach (qualitative) Z. Bélteczki1* , P. Döme2 , X. Gonda2 , J. Újvári1 , Z. Rihmer2
1 Kálmán Sántha Psychiatric Hospital, I. Psychiatric Department,
Results.– Hanging and self-poisoning were the prominent meth-
ods. Suicide notes revealed themes of self-guilt/blame, apology, Nagykálló, Hungary; 2 Department of Psychiatry and Psychotherapy,
bereavement, hopelessness and advice/prayers for loved ones. Semmelweis University, Budapest, Hungary, National Institute for
Their unmet needs were mainly lack of audience, increased social Psychiatry and Addictions, Budapest, Hungary, Budapest, Hungary
demands, lack of awareness about mental-health resources, lone-
liness, somatic complaints and loss of self-autonomy. Complaints Background and aims.–
about cognitive decline and significant stigma about the ‘act of sui- Introduction.– Estimation of suicide risk is difficult task, and the
cide’ were predominant post-survival. Almost all of them visited clinical utility of different suicide risk scales is far from ideal.
at least one medical practitioner within two weeks prior to the Objectives.– Previously we have developed a 6-item, clinician-rated
attempt, which was alarming. (yes/no) questionnarie that has been able to detect current and
Conclusions.– There is significant dearth of data on suicide- past suicide risk with high sensitivity and specificity among acutely
survivors, more so in elderly where the risk is double. Our study admitted psychiatric inpatients (Rihmer et al., 2018). In the present
showed that awareness and structured assessment of the risk, early study we report preliminary data on short-term follow-up.
identification of cognitive complaints and decreasing stigma can be Methods.– Methods: The 151 (75 suicidal and 76 non-suicidal) psy-
fundamental in preventing geriatric mortality due to suicide. chiatric inpatients, admitted between 1 November 2016 and 31
Disclosure of interest.– The authors have not supplied a conflict of March 2017 were followed till 31 September 2018. Cases of com-
interest statement. pleted suicides and suicide attempters receiving medical attention
were recorded.
Results.– Results: During the 18-month follow-up 2 patients (1.3%)
E-PP1241
completed suicide (a 46 year old male with Bipolar II disorder and
The variability of regional suicide a 57 year old female with Schizoaffective disorder). Both of them
rates in Poland - searching for were at baseline among the 75 suicidal inpatients and belonged to
explanations the group of “Marked suicide risk” (range: 16–28 points) and scored
A. Baran1* , A. Gmitrowicz2 , K. Krysinska3 , P. Kropiwnicki2 28 and 26 points, respectively. Suicide attempts has been made by
1 Blekinge Hospital, Department of Psychiatry, Karlshamn, Sweden; 2 6 patients all of them belonged to initially “Marked suicide risk”
Medical University of Lodz, Department of Adolescent Psychiatry, group (one initially nonsuicidal, 16 points and 5 initially suicidal,
Lodz, Poland; 3 University of New South Wales, Centre for Primary 22, 26, 26, 26, and 28 points, respectively)
Health Care and Equity, Sydney, Australia Conclusions.– Conclusion: Despite the short follow-up and the small
* Corresponding author. number of suicidal cases, our preliminary results suggest that this
short, simple questionnarie might be helpful not only in detecting
Background and aims.– In the years 2007–2016 over 5,800 people current asnd past suicidality but also predicting future suicide risk
took their lives annually in Poland, what ranked Poland among among discharged psychiatric inpatients.
European countries with the highest number of suicides. The aim of Disclosure of interest.– The authors have not supplied a conflict of
the study was to analyze variables potentially influencing regional interest statement.
suicide rates and to present them in a visual way.
Methods.– Data on suicide and selected demographic, socioeco-
nomic, health and healthcare variables for 16 NUTS-2 regions (pl. E-PP1243
“województwo”) were obtained from the Statistics Poland (GUS). Specificities of mental health
Age-specific suicide rates for age groups 15–24, 25–44, 45–64 and problems in the countries of the
65+ were calculated. Suicide rates, as well as selected risk factors
Maghreb region, through scientific
for suicide for three years: 2007 (the lowest suicide rate), 2009
and 2013 (both the highest suicide rates) were presented using the
publications on the theme of suicide.
cartographic approach. a systematic review
Results.– Suicide rates showed a relatively stable pattern. The M. Ben Alaya1* , S. Ben Youssef2 , A. Ben Abdelaziz2
1 Sahloul Hospital, Preventive and Community Medecine
regional suicide rates were the highest in the western part of Poland
(along the German border) and the lowest in southern Poland Department, Sousse, Tunisia; 2 Sahloul Hospital, Preventive and
˛
(Ślaskie and Opolskie). Suicide rates in 2009 and 2013 increased Community Medecine, Sousse, Tunisia
in the areas with the increase of the percentage of population over
65 years old, mortality rates, divorce rates and GDP.
Background and aims.– In an article published in the journal “La
Conclusions.– Cartographic approach helps to better understand
Tunisie médicale” in 1972, Professor Sleim Ammar, a visionary
differences in regional suicide rates in Poland, which are related to
North African psychiatrist, announced: “suicide is a public health
the profile of risk variables that are relatively stable and specific for
problem.”
the different NUTS-2 regions. Differences in regional suicide rates
This work aims to describe the profile of Maghreb publications,
in various age groups, and related to demographic, socioeconomic,
indexed in the Medline database, on the topic of suicide during the
health and healthcare variables, should be taken into account when
last forty years, and to extract the Maghreb specificities of the epi-
planning and implementing national and regional suicide preven-
demiology and the suicide management, used as tracer of Maghreb
tion strategies.
mental health.
Methods.– This is a systematic medical review, on the theme of “sui-
interest statement.
cide” in Maghreb region. We submitted a distinct and clear search
term to the Medline database, via its online interface, “PubMed”,
on May 16, 2018. we described the bibliometric characteristics of
these Maghreb studies, synthesized the analysis of their content, Tunis, Tunisia; 3 Razi Hospital, Sfar Department, Tunis, Tunisia; 4
detailed the documented facts and the recommended proposals. Ministry of Health, National Institute of Public Health, Tunis, Tunisia
Results.– Out of 32 Maghreb articles on suicide, selected for this * Corresponding author.
literature review, 18 were Moroccan and 13 were Tunisian. Two-

thirds of them published after 2010. The snapshot of Maghreb Background and aims.– Suicide is a major public health problem
research indexed on Medline, on suicide, was: a publication written both globally and nationally. An increase in the suicide rate with
in French, focused on the attempts of suicide, with a monocentric new trends have been noticed since the revolution in Tunisia, but
and descriptive methodological approach, written by a psychiatry few national data were available to give account of the extent of
team and published in an “open access” African journal. The rec- this phenomenon.
ommendations of these publications were often general and not Aims: to analyze the trend of suicide in Tunisia over 5 years and to
operational. deduce the evolutionary patterns according to age, sex and suicidal
Conclusions.– The north african scientific research on suicide means.
remains unproductive and of low methodological quality. The focus Methods.– A retrospective and cross-sectional study, including all
towards primary suicide prevention, as part of a comprehensive the autopsied cases for which there was a strong presumption to
public health approach, would be essential for the promotion of correspond to a suicide and this in all of the Legal Medicine Depart-
mental health in the region ments of Tunisia between January 2012 and December 2016.
Disclosure of interest.– The authors have not supplied a conflict of Results.– We collected 1598 cases of suicide over the 5 years of
interest statement. study. The average age was 36.51 years with a sex ratio of 2.60.
The prevalence of suicide showed a significant rise between 2013
and 2015; from 2.51 to 3.27 per 100,000 inhabitants; followed by
E-PP1244 stabilization between 2015 and 2016. Adults aged between 25 and
Emotion dysregulation and suicidal 35 years accounted for the quarter of the population. Men had 3
times more use of violent means than women. Hanging was the
ideation: the role of dysregulation of
most frequently used method for both sexes (57.38% for males and
positive emotions 41.24% for females), followed by self-immolation for males (20.5%)
S. Beomonte Zobel1* , G. Rogier1 , P. Velotti2 and drug ingestion for women (28.38%).
1 La Sapienza Università di Roma, Dynamical and Clinical Psychology, Conclusions.– Our results confirm the vulnerability of young male
Rome, Italy; 2 University of Genoa, Educational Sciences, Genoa, Italy adults to suicide, the strong propensity for violent means and the
new self-immolation’s trend after the revolution. Urgent preven-
tive measures as part of a national strategy are much needed.
Background and aims.– Suicide is a major health issue worldwide
and a substantial body of research claims that difficulties in the reg-
interest statement.
ulation of negative emotions (rather than emotion themselves) may
play a predominant role in suicidal ideation and in suicidal behav-
ior. However, limited research has explored the role of difficulties
E-PP1246
in the regulation of positive emotions in suicidal ideation.
This study aims to explore this connection in a non-clinical sam- Risk of suicidal recurrence in patients
ple. We hypothesized that individuals that report greater difficulty with family dysfunctions
in regulating negative emotions would be more likely to present R. Boukhchina1* , L. Ghanmi1 , M. Abbes1 , R. Ben Fradj1 , K. Zitoun1 ,
suicidal ideation and that difficulties in the regulation of positive N. Charfi2 , L. Zouari2 , M. Maalej2
1 Regional Hospital of Gabès, Psychiatry Department, Gabès, Tunisia;
emotions could mediate this relationship.
2 University Hospital Hedi Chaker, University of Sfax, Psychiatry « C »
Methods.– Participants included 150 undergraduate students.
Demographic information, including clinical history, were col- Department, Sfax, Tunisia
lected in a form. Suicidal ideation was assessed using Beck Suicide
Ideation Scale (BSI; Beck & Steer, 1991), difficulties in regulation of
Background and aims.– Although several factors are associated with
negative emotions were assessed using Difficulties in Emotion Reg-
suicidal behavior, it seems that family dysfunction predisposes
ulation Scale (DERS; Gratz & Roemer, 2004), whereas difficulties in
patients to suicide attempts.
the regulation of positive emotions were assessed with Difficulties
We aimed to investigate the family factors associated with suicidal
in Emotion Regulation Scale - Positive (DERS-P; Weiss et al., 2015).
recurrence in suicidal outpatients followed at the department of
Results.– Analyses were conducted to determine the relationship
psychiatry of Gabes.
between dysregulation of negative emotions and suicidal ideation,
Methods.– This was a retrospective descriptive and analytical study.
confirming literature, and the mediating role of difficulties in reg-
The study focused on all the patients who attempted suicide and
ulation of positive emotions.
who were referred to the department of psychiatry of the regional
Conclusions.– The generalizability of our findings may be limited
hospital of Gabes. Patients were questioned about their socio-
due to the small size of our sample and to demographic characteris-
demographic characteristics and their family environment.
tics. So further research is needed to explore deeply the relationship
Results.– 124 patients were included. They were females (82.3%)
between emotion dysregulation and suicidal ideation.
and singles (82.3%). The mean was age 25 years. Suicidal patients
lived in a disrupted family environment in 52.4% of cases, marked
interest statement.
by the presence of intra-family conflicts (25.8%), a mental disorder
in one of the parents (16.9%) and abuse (15.3% of cases). A family
E-PP1245 history of suicide suicide attempt in the family was present in 4%
of cases. The univariate analysis showed that suicidal recurrence
Evolution of the suicide trend in
was significantly associated with the presence of a mental disor-
Tunisia: a national study from 2012 to der in one parent (33.3% vs. 14.6%, p = 0.05) and parental divorce
2016 (66.7% vs 13.9%, p = 0.001). The multivariate analysis showed that
N. Ben Mabrouk1 , F. Charfi1 , M. Ben Khelil2 , G. Boukhari3* , A. only the presence of a psychiatric history in one of the parents was
Skhiri4 , A. Belhadj1 , M. Hamdoun2 a determinant of the risk of suicidal recurrence (OR = 6.9 [1,2–38],
1 Mongi Slim Hospital, Child and Adolescent Psychiatry Department,
p = 0,02)
Tunis, Tunisia; 2 Charles Nicolle Hospital, Legal Medicine Department,
Conclusions.– This study demonstrates the importance of consid- cide than in the general population, which makes its management
ering the family environment when examining suicidal ideation in the Emergency Department (ED) extremely valuable. There are
patients. no specific evidence-based suicide prevention strategies for this
Disclosure of interest.– The authors have not supplied a conflict of age group and it is not known whether the ones designed for the
interest statement. general population are suitable. The aim of this study is to evaluate
the rate of repetition of DSH in older adults in comparison to young
adults.
E-PP1247 Methods.– We conducted an observational study including 1616
Brain derived neutrophic factor patients receiving medical and psychiatric care after a DSH at a
serum levels in suicide attempters general hospital ED between years 2013 and 2016. The principal
Z. Bouzaabia1* , A. Mtiraoui1 , A. Abbadi1 , A. Souilem1 , M. Achour2 , outcome measure was ED return due to DHS. Time to relapse was
S. Saguem2 , S. Ben Nasr1 obtained from hospital records. We derived Kaplan-Meier survival
1 Farhat Hached Hospital, Psychiatry Department, Sousse, Tunisia; 2 functions. Cox proportional hazard regression models were used to
Faculty of Medicine Ibn El Jazzar, Laboratory of Metabolic Biophysics estimate unadjusted and adjusted hazards of relapse by social and
and Applied Pharmacology, Sousse, Tunisia clinical covariates.
* Corresponding author. Results.– The Kaplan-Meier survival function of reattempts in young
(blue) and older adults (grey) with its 95% CI its shown. A sta-
Background and aims.– Suicidal behaviour is a complex phe- tistically significant difference was founded, HR (95%CI): 0.82
nomenon with a multitude of risk factors. Brain-Derived Neu- (0.72–0.95). However, this difference is lost after adjusting by sex
rotrophic Factor (BDNF), a protein crucial to nervous system an presence of psychiatric diagnose, sustance abuse and family sup-
function, may be involved in suicide risk. port (figure 1).
The aim of this study was to assess serum level of BDNF in suicidal
patients and to determine associations between BDNF levels and
psychopathological features.
Methods.– We have conducted a case-control study. Suicide
attempters who have been received in emergency department or
intensive care unit of Farhat Hached Hospital of Sousse, Tunisia,
free from chronic inflammatory or autoimmune disorders were
recruited. They were compared to control subjects, matched
for age, sex and body mass index, enrolled among volunteer
blood donors. Current symptoms were assessed with depression
(Beck Depression Inventory), anxiety (Hamilton Anxiety Scale) and
impulsiveness (Barratt Impulsiveness Scale). Serum BDNF levels
were measured with ELISA techniques.
Results.– Thirty-one patients were recruited. They had an aver-
age age of 26.00 ± 9.80 years with a sex ratio of 0.4. At the time
of the evaluation, 87.1% had severe depression and 48.4% mod-
erate to severe anxiety and 12.9% had a high despair score. No
significant difference was found between patients and controls Figure 1. Kaplan-Meier survival estimates
regarding BDNF serum levels. There were no association between
Conclusions.– In the studied cohort the lower frequency of DSH of
serum BDNF level and clinical and psychopathological data.
older adults is lost after adjusting by other known significant vari-
Conclusions.– Our results argue against the involvement of BDNF in
ables. Therefore, it is possible that the described suicide prevention
suicidal behavior. These results should be viewed with caution due
strategies for the general population are useful in this age group.
to the small number of subjects recruited in this study as well as
the non exploration of the BDNF gene polymorphism.
interest statement.
interest statement.
E-PP1249
Suicide prevention strategies
E-Poster Presentation: Suicidology and suicide P. Câmara Pestana1* , G. Marinho2
1 Santa Maria University Hospital, North Lisbon Hospital Center,
prevention - Part II
Neurosciences Department, Psychiatry and Mental Health Service,
Algés, Portugal; 2 CHPL Lisbon Psychiatric Hospital, Central Lisbon
Hospital Center, Department of Psychiatry, Lisbon, Portugal
E-PP1248 * Corresponding author.
Deliberate self-harm reattemps in
older adults in emergency Background and aims.– Suicide is defined as death caused by self-
directed injurious behavior with intent to die. The difficulty of
department: an observational cohort establishing a standard of care for the management of suicide risk
study is a recurrent problem.
D.H. Calle1* , G. Martínez-Alés1,2,3 , E. Román1 , E. Jiménez1 , P. Aim.– To compare the different suicide prevention strategies avail-
Sánchez1 , B. Rodríguez1,3 , M.F. Bravo-Ortiz1,3 able.
1 Hospital Universitario La Paz, Psychiatry, Madrid, Spain; 2
Methods.– Nonsystematic literature review using the following
Columbia University, Psychiatric Institute, New York State, USA; 3 keywords “suicide”, “suicide risk assessment”, “suicide prevention
Universidad Autónoma de Madrid, Psychiatry, Madrid, Spain contract”, “no-suicide contract” and “suicide prevention”.
Results.– We found four different approaches to suicide prevention.
The suicide prevention contract (SPC) whereby a patient’s promise
Background and aims.– Older adults have the highest suicide rates.
of safety is obtained in the context of suicidal thoughts, impulses,
Deliberate self-harm (DSH) is a better predictor for completed sui-
or behaviors; The crisis response plan (CRP), where a plan is written
on a small card that outlines the steps for identifying one’s personal E-PP1251
warning signs, using coping strategies, activating social support and Altered RNA editing in PDE8A mRNA
accessing professional services; The safety planning (SP), a compo-
in suicide brain
nent of a cognitive behavioral therapy (CBT) for suicide prevention,
F. Chimienti1* , L. Cavarec2 , L. Vincent3 , N. Salvetat1 , V. Arango4 ,
where the provider and patient list strategies for the patient to use
M.D. Underwood4 , M. J. John4 , J.F. Pujol1 , D. Weissmann1
when suicide ideation is elevated and Brief CBT (BCBT), a 12-session 1 ALCEDIAG, Sys2Diag – ALCEDIAG/CNRS UMR9005, Montpellier,
outpatient psychotherapy.
France; 2 Genomic Vision, Green Square, Bagneux, France; 3
Conclusions.– We found that SPC was largely ineffective or poten-
Commissariat à l’Energie Atomique, Fontenay, Fontenay Aux Roses,
tially even harmful; CRP was more effective than SPC; SP, although
France; 4 New York State Psychiatric Institute, 4. Division of
some positive results, has not been yet definitely tested and BCBT
Molecular Imaging and Neuropathology, New York, USA
reduced significantly the suicide attempts in some samples. Addi- * Corresponding author.
tional research is warranted to further clarify which components of
the different strategies contribute most to reduce suicidal thoughts Background and aims.– Phosphodiesterases (PDE) are key modula-
and behaviors. tors of signal transduction and are involved in inflammatory cell
Disclosure of interest.– The authors have not supplied a conflict of activation, memory and cognition. There is a two-fold decrease in
interest statement. the expression of phosphodiesterase 8A (PDE8A) in the temporal
cortex of major depressive disorder (MDD) patients, PDE8A mRNA
editing is modified by interferon a treatment.
E-PP1250 We studied PDE8A mRNA-editing profile in two distinct cortical
Suicidality, mood disorder and regions in a clinically well-characterized cohort of age- and sex-
personality pathology in adolescence matched controls and depressed suicide decedents to assess the
M.P. Casini1* , C. Frattini1 , R. Williams2 , G. Serra1 , M. Trasolini1 , S. role of RNA editing as a biomarker of suicidality.
Vicari1 Methods.– We used RT-PCR and capillary electrophoresis single-
1 Bambino Gesu’ Children’s Hospital IRCCS, Department of stranded conformational polymorphism (CE-SSCP) to specifically
Neuroscience, Rome, Italy; 2 “La Sapienza” University, Dynamic and identify A-to-I RNA modifications in PDE8A intron 9 mRNA.
Clinical Psychology Departement, Rome, Italy Results.– We report the full editing profile of PDE8A in the brain,
* Corresponding author. including identification of two novel editing sites. Editing of PDE8A
mRNA displayed clear regional difference when comparing dor-
Background and aims.– Suicide prevention represents a primary solateral prefrontal cortex (BA9) and anterior cingulate cortex
global Health goal (WHO, 2014). Many psychopathological condi- (BA24). Furthermore, we report significant intra-regional differ-
tions, mainly Mood and Adaptive disorders, have been considered ences between non-psychiatric control individuals and depressed
to account for suicidality in adolescence, but only few studies have suicide decedents, which could discriminate the two populations.
investigated the role of personality pathology. Aim of the study is to Conclusions.– Our results highlight the importance of immune
analyse the role of mood disorders, personality disorders and traits biomarkers in major depressive disorder and suicide, and provide
in adolescence suicidality. the first immune response-related biomarker for suicidality iden-
Methods.– 52 adolescents assessed as at risk for suicidality in tified in the brain. As PDE8A can be detected in white blood cells,
the Mood Disorder Program of Bambino Gesù Children’s Hospi- the link between PDE8A mRNA editing and suicide could pave the
tal, were assessed with: Columbia Suicide Severity Rating scale; way for the identification of a blood-based biomarker that predicts
Kiddie Schedule Affective Disorder and Schizofrenia (K-SADS); suicidal behavior.
Child Depression Rating Scale; SCID II; K-SADS-Mania Rating Scale. Disclosure of interest.– The authors have not supplied a conflict of
Bivariate and partial correlations were performed for continuous interest statement.
variables and 2 for dichotomous ones.
Results.– Mood disorders are significantly correlated with severity
and intensity of suicidal ideation and the presence of suicidal E-PP1252
conduct, in a partial correlation model controlling for personality Relationship of internet gaming
disorders and traits, only intensity and severity of ideation are still
disorder symptoms with
correlated with the severity of depressive and maniac symptoms.
Either a Cluster B personality disorder diagnosis or traits are self-mutilative behaviour among
significantly correlated with suicidal conducts, lethality of the act young adults
and NSSI. In a partial correlation model controlling for the severity C. Evren1* , B. Evren2 , E. Dalbudak3 , M. Topcu4 , N. Kutlu5
1 Bakirkoy Training and Research Hospital for Psychiatry Neurology
of depression and/or maniac symptoms, those correlations with
Cluster B personality traits, are still significant. and Neurosurgery, Research, Treatment and Training Center for
Conclusions.– Results seem to indicate two possible different psy- Alcohol and Substance Dependence AMATEM, Istanbul, Turkey; 2
chopathological pathways of risk for suicidality in adolescence: Baltalimani State Hospital for Muskuloskeletal Disorders,
mood disorders and symptoms are associated with suicidal ideation Department of Psychiatry, Istanbul, Turkey; 3 Private practice, Private
and attempts, while pathological personality traits and diagnoses, Practice, Ankara, Turkey; 4 Cankaya University, Ankara, Turkey,
namely, BPD, HPD, NPD are associated with the whole gamut of Department of Psychology, Ankara, Turkey; 5 Baltalimani State
suicidal conducts. Hospital for Muskuloskeletal Disorders, Department of Psychology,
Disclosure of interest.– The authors have not supplied a conflict of Istanbul, Turkey
interest statement.
Background and aims.– The aim of the present study was to evalu-
ate relationship of Internet gaming disorder (IGD) symptoms with
self-mutilative behaviour (SMB), while controlling the effects of
depression, anxiety, neuroticism and extraversion among young
adults.
Methods.– The study was conducted with online survey among
1010 volunteered university students in Ankara and people who
play games on the Internet and who are in the e-mail database
of a company located in Istanbul that organizes e-sports tour- sions demonstrating the role of regional differences as moderators
naments. Participants were evaluated by applying the Internet of this relation in both clinical and nonclinical sample.
Gaming Disorder Scale – Short Form (IGDS-SF), the Eysenck Person- Disclosure of interest.– The authors have not supplied a conflict of
ality Questionnaire Revised-Abbreviated Form (EPQR-A), the Beck interest statement.
Anxiety Inventory (BAI) and the Beck Depression Inventory (BDI).
Results.– Age and gender did not differ between those with SMB
(n = 207, 20.5%) and those without SMB (n = 803, 79.5%). IGDS9- E-PP1254
SF, depression, anxiety, neuroticism and extraversion scores were Mental health and arquitecture: one
higher among those with probable ADHD. In linear regression anal- solution for a suicide hotspot
ysis, severity of IGD predicted the presence of SMB, together with S. Farinha Silva* , M.T. Valadas, P.R. Barbosa, A. Matos-Pires
depression, anxiety and neuroticism. Unidade Local de Saúde do Baixo Alentejo, Psychiatry, Beja, Portugal
Conclusions.– These findings suggest that the severity of IGD is * Corresponding author.
related with the presence of SMB, together with depression, anxiety
and neuroticism among young adults. Background and aims.– Baixo Alentejo (BA), a region in Portugal, has
Disclosure of interest.– The authors have not supplied a conflict of one of the country’s highest suicide rates. Several sites considered
interest statement. “suicide hotspots” have been recognized in this region. There is no
exact number of suicides required to identify such a place. More
than one suicide occurring at a particular location suggests it pro-
E-PP1253 vides means or opportunity for suicide, and may therefore warrant
Suicide and spirituality: a multicenter intervention.
study of Austrian and Italian Silos of Moinhos de Santa Iria, located in Beja, BA, are an abandoned
building complex that has been identified as one of Beja’s “suicide
psychiatric patients and students
hotspots”. There has been at least one death by suicide per year at
G. Falcone1* , S. Stefa-Missagli2 , H.F. Unterrainer3 , G. Giupponi4 ,
this site for the past 5 years.
S.J. Wallner-Liebmann5 , H.P. Kapfhammer6 , A. Conca4 , M. Sarlo7 , I.
Within the “Setembro Amarelo” (“Yellow September”) campaign,
Berardelli1 , K. Krysinska8 , K. Andriessen9 , A. Nardella1 , D. Erbuto1 ,
we aimed to raise local awareness regarding suicide prevention
H. Moujaes-Droescher10 , K. Davok10 , M. Pompili1
1 Sapienza, University of Rome, NESMOS Department Neurosciences, and to develop interventions that may be implemented in order to
reduce the risk of suicide at this particular “suicide hotspot”.
Mental Health and Sensory Organs, Sant’Andrea Hospital, Rome,
Methods.– We invited a group of architecture students and teachers
Italy; 2 Medical University, University Clinic for Psychiatry, Graz,
to develop projects for the rehabilitation of Silos of Moinhos de Santa
Austria; 3 Medical University, Karl-Franzens-University, University
Iria.
Clinic for Psychiatry, Institute of Psychology, Graz, Austria; 4
Results.– Three projects were developed: one for a hotel and spa,
Südtiroler Sanitätsbetrieb, Clinic for Psychiatry, Bolzano, Italy; 5
one for a workshop and market and another for a student’s resi-
Medical University, Institute of Pathophysiology and Immunology,
dence and study/investigation facilities.
Graz, Austria; 6 University Clinic for Psychiatry, Medical University,
Conclusions.– Means restriction is not the only valid suicide pre-
Graz, Austria; 7 University of Padova, Department of General
vention strategy. Spaces and structures can be transformed and
Psychology, Padova, Italy; 8 Centre for Primary Health Care and
rehabilitated. We believe that the collaboration between architects
Equity, University of New South Wales, Sidney, Australia; 9 Centre for
and psychiatrists is a complementary partnership, because both
Mental Health, School of Population and Global Health, The
professional groups, however distinct they may be, share a point
University of Melbourne, Parkville, Australia;
10 Karl-Franzens-University, Institute of Psychology, Graz, Austria of convergence, and this multidisciplinary work contributes to a
* Corresponding author. continued improvement of mental health and quality of life.
Background and aims.– In recent years a growing interest is emerg- interest statement.
ing in determining the role of religiosity and spirituality on suicide
risk. Different dimensions of spirituality/religiosity, including Spir-
itual Well-Being would represent either a risk factor or a protective E-PP1255
factor for suicide. Suicide in video-games:
The principal aim of this research, which is part of a larger mul- representation of suicide-related
ticentre study, was to determine the role of the different faces behaviours in video-games
of spirituality/religiosity on suicide risk. According to the impor-
throughout the years
tance of cultural differences on suicide risk, the second aim of this
M. Felizardo
study was to identify the possible mediators of the relation between
Centro-Hospitalar Tras-os-Montes-e-alto-Douro, Psychiatry, Vila
spirituality/religiosity and suicide risk.
Real, Portugal
Methods.– 1043 people were tested in central Italy, northeast Italy
Background and aims.– Suicide is a complex and intricate subject
and eastern Austria. The questionnaires were filled in by 410 psy-
that is many times portrayed in video games, whether as a reference
chiatric inpatients and 633 university students. This measures
or as being the main theme. Within the entertainment business,
were applied: Sociodemographic questionnaire, Columbia-Suicide
gaming industry is growing fast with new games being released
Severity Rating Scale-B, Symptom-Checklist-90-Standard, Big Five
every day. The list of games that cointains suicide-related behavior
Inventory, Multidimensional Inventory for Religious/Spiritual Well-
is vast and perhaps it’s crucial to understand how suicide-related
Being (MI-RSB), and International Statistical Classification of Diseases
content has been represented in games throughout the years.
and Related Health Problems.
We aim to find out how suicide is being portrayed in video-games.
Results.– The dimension of MI-RSB “Religious/Spiritual Well-Being”
We intend to know how suicide is being displayed for the players
“Hope Immanent” and “Connectedness” presented in both sam-
and what are their reactions based on their reviews.
ples the strongest negative relation to all suicide dimensions and
Methods.– We include video games released in the last 10 years that
to psychiatric symptoms. The risk factor or the protective factor of
have strong references of suicide-related behaviour or that have
different faces of Religiosity (MI-RSB) were significantly influenced
suicide as the main theme. Search was conducted using magazines,
by regional differences and clinical state.
websites and all gaming platforms were included. Reviews were
Conclusions.– Our study confirmed the multifactorial nature of the
analysed to understand how people felt about the game.
relation between suicide risk and various religious/spiritual dimen-
Results.– On a psychological and emotional level, research has been 1 Razi Hospital, Department of Child and Adolescent Psychiatry,
showing that gamers can become more desensitized to realistic Mannouba, Tunisia; 2 Faculté de Médecine de Tunis, Department of
risk behaviours. Suicide-related content is sometimes depicted in Child and Adolescent Psychiatry, Mannouba, Tunisia
games with raw brutallity and corresponding imagery. Other times, * Corresponding author.
suicide is seen as an escape or a sacred act and there are games

where suicide is displayed as a choice. Background and aims.– The profile of youth being referred to a psy-
Conclusions.– Video-games, like books and movies, are an interac- chiatric health care for suicidal attempt is evolving in Tunisia in
tive tool that can be used to promote healthy behaviours and its recent years. Considering the seriousness of the act, understanding
important to understand how suicide-related behaviour is being this change is necessary for all health professionals.
presented and grasped by the people to possibly outline future Objective.– The aim of our study was to determine the sociode-
strategies of intervention. mographic characteristics of the suicidal youth consulting the
Disclosure of interest.– The authors have not supplied a conflict of emergency of the child and adolescent psychiatric department at
interest statement. Razi hospital, the reference center at Tunis, capital of Tunisia.
Methods.– Two hundred and four patients consulted the emergency
of the child and adolescent psychiatric department at Razi hospi-
E-PP1256 tal between January and December 2017. Sociodemographic and
Increased suicide risk in major clinical data were collected using a pre-established grid.
Results.– In our population, 36.8% of the patients consulted for suici-
depressive disorder patients related to
dal attempt. The average age was 13.32, ranging from 7 to 17 years
single nucleotid polymorphisms in old. The sex ratio was 0.1. Of these patients, 16.9% have already
leptin receptor gene made at least one suicide attempt and 5.7% have an history of self-
J. Fernandez Aurrecoechea1* , R. Carmona Camacho1 , P. Fernandez harm. Twenty two percent have personal psychiatric antecedents
Navarro2 , C. Vaquero Lorenzo3 , E. Baca Garcia1 and 29.5% have been abused or neglected. Thirty three percent were
1 Hospital Universitario Fundacion Jimenez Diaz, Psychiatry, Madrid,
exposed to domestic violence. Thirty eight percent of the patients
Spain; 2 Instituto de Salud Carlos III, Epidemiology, Madrid, Spain; 3 had a low socio-economic level. Familial psychiatric antecedents
Universidad Autonoma de Madrid, Biology, Madrid, Spain have been reported in 33.8% of cases.
Conclusions.– The profile is changing in favor of girls and the
increase of risk factors. This study offers some information to
Background and aims.– Suicide stands for approximately one mil- understand the predictors of suicide in Tunisian youth and stress
lion of deaths per year worlwide, being one of the most dramatic the urgent need of preventive strategies.
public health problems. Mental disorders explains almost 90% of Disclosure of interest.– The authors have not supplied a conflict of
comitted suicides, with high rates of depression amongst them. interest statement.
One of the vast studied issues on suicidal behavior has been lipid
metabolism and genetics. In this sense, there are two studies that
linked suicidal behavior with low serum levels of leptin, results con-
sistent with the finding of decreased leptin brain levels in suicide E-Poster Presentation: Suicidology and suicide
victims; and another one demostrated that leptin receptor gene prevention - Part III
was downregulated in depresive suicide completers.
The aim of the present study is that there are leptin genetic poly-
morphisms related to suicidal behavior in patients with depression.
E-PP1258
The objective, therefore, is to verify the effect on suicidal behavior
in patients with depression of polymorphic variants and haplotypes Relationship between particulate
of genes related to lipid metabolism. matter air concentrations and
Methods.– A retrospective case-control study analyzed polymor- suicides in Poland in 2014 and 2015
phic variants in leptin receptor gene in depressive patients with A. Gładka1* , J. Blachowski2 , J. Rymaszewska1 , T. Zatoński3
an attempted suicide. The sample consisted of 791 subjects: 414 1 Wroclaw Medical University, Department of Psychiatry, Wroclaw,
healthy controls and 377 depressive patients (245 had a suicide Poland; 2 Wroclaw University of Science and Technology, Faculty of
attempt and 132 had not, who also served as depressive control Geoengineering, Mining and Geology, Geodesy and Geoinformatics
group.) Unit, Wroclaw, Poland; 3 Wroclaw Medical University,
Results.– A multinomial logistic analysis adjusted for age, sex, diag- Otolaryngology, Head and Neck Surgery Department, Wroclaw,
nosis of anxiety and substance use was performed and a total Poland
of three statistically significant polymorphisms in leptin recep- * Corresponding author.
tor gene were found (p < 0.05) related to the suicidal behavior of
depressive patients: rs1137101, rs1805134 and rs3806318. Background and aims.– Particulate matter (PM2.5 and PM10) con-
Conclusions.– These are promising and new findings that relate lep- centrations and suicide rate in Poland are substantially higher than
tin receptor gene polymorphisms and suicidal behaviour in major in other European countries. The possible relationship between
depressive disorder. long-term particulate matter levels and suicide rate requires using
Disclosure of interest.– The authors have not supplied a conflict of various methods of investigation. Therefore, the aim of our study
interest statement. was to evaluate this association by using geographic information
system (GIS) and aspatial regression.
Methods.– Population and air pollution data were extracted from
E-PP1257 the Polish Central Statistics Office and Chief Inspectorate of
Profile of patients consulting in Environmental Protection for the period 2014–2015. Aspatial mul-
emergency for a sucide attempt in a tivariate and one factor regression analysis were performed and
followed by spatial global regression analysis for voivodship refer-
clinical population of child and ence units in geographic information system (GIS).
adolescent psychiatry Results.– At the voivodeship level of aggregation data showed spa-
M. Ghazzai1* , N. Toujani2 , S. Ghezaiel1 , S. Halayem1 , Z. Abbes tial stationarity. The best-fitting spatial global model was based on
Ghorbel Salma1 , M. Hajri1 , A. Bouden1 number of disorders caused by the use of psychoactive drugs, num-
ber of people treated in psychiatric hospitals, population density, after a suicide attempt present. We hypothesize basing on existing
unemployment rate and per capita income. Global spatial model literature that these patients will have moderate or high levels of
with PM2.5 level parameter was an improvement over the one inflammation.
without it (adj. R2 = 0.87 compared to adj. R2 = 0.83). Methods.– We have collected data during six months on all patients
Conclusions.– Particular matter concentrations and suicides in who have been interned in a Psychiatric Hospital. We collected
Poland have a positive relationship. Application of Geographic sociodemographic data, autolytic attempts, substance abuse prob-
Information System analytical functions in medicine can be viewed lems, physical activity, chronic diseases, treatment and adherence
as a new efficient methodological approach. to it. A sample of blood was taken including (Leukocytes, Fibrino-
Disclosure of interest.– The authors have not supplied a conflict of gen, PCR, Vitamin D, and Prolactin) in addition we collected their
interest statement. body mass index and registered if they had fever or an infection
(exclusion criteria). Afterwards the levels of PCR of the patients
who had make a suicide attempt were analyzed and classified in
E-PP1259 low, medium or high level of systemic inflammation.
Milestones in the development of Results.– Out of the 36 patients that were hospitalized after hav-
national suicide prevention strategy ing made a suicide attempt, 11 patients were excluded due to
PCR > 10 mg / L. Among those 25 patients, 40% had a moderate level
in Poland
of systemic inflammation and 28% had a high level.
A. Gmitrowicz1* , A. Baran2 , K. Ostaszewski3
1 Conclusions.– In our sample, 68% of patients who made a suicide
Medical University of Lodz, Department of Adolescent Psychiatry,
attempt had moderate or high levels of systemic inflammation.
Lodz, Poland; 2 Blekinge Hospital, Department of Psychiatry,
These results support the hypothesis in which there is a signifi-
Karlshamn, Sweden; 3 Institute of Psychiatry and Neurology in
cate relationship between PCR levels and the presence of suicidal
Warsaw, Department of Psychology and Promotion of Mental Health,
behaviors.
Warsow, Poland
interest statement.
Background and aims.– Poland has a relatively high suicide rate
(about 15,2/100,000). Taking this situation into account a national
suicide prevention strategy has been developed. E-PP1261
The aim is to analyze the milestones in the process of building Polish Features of self-harm behavior of
suicide prevention strategy, including factual data and legal basis. adolescents associated with the
Methods.– The important events in suicide prevention since 2000 substances use
on a national level have been identified. The stages in the devel- A. Grigorieva
opment of Polish suicide prevention strategy are described in the V. Serbsky National Medical Research Centre of Psychiatry and
chronological order. Narcology of the Ministry of Health of the Russian Federation, Senior
Results.– Polish Suicidological Association established in 2002 Researcher of Department of Preventive Care in Narcology, Moscow,
became a center of scientific activity, including advocacy and Russia
annual publication of “Suicidology”. Another important milestone Background and aims.– An investigation of the self-harm behavior
was a suicidological conference in 2015 in Lodz, with the participa- of adolescents.
tion of representatives of Ministry of Health. In 2016, the National Methods.– Anonymous screening study of schoolchildren (10–18
Health Program pointed out responsibility of Ministry of Health for years, n = 1780). Personal belief questionnaire – borderline person-
the development of suicide prevention. This document resulted in ality disorder (Butler et.al., 2002); “Method of body modification
creating the Working Group on Prevention of Suicide and Depres- and self-harm” (Polish N.A, 2017); “Suicidal personality-19”
sion (2016) with its important advisory role. It brings together (Yunatskevich P.I., 2009); “Express test to identify attitude of ado-
suicidologists, psychiatrists, public health experts, representatives lescents to the substance use”; questionnaire “Risk group of drug
of Ministries, Statistics Poland, Police, NGOs and media. Three sub- addiction” (Khasan B.I., Tyumeneva Y.A., 2003), A single-factor anal-
groups were created to help with: 1/ development of a website for ysis of variance was used, SPSS17.
national online and telephone support for people in mental health Results.– For 10–11 years, the presence of body self-harm (SH) -
crisis, 2/ development of a central registry of suicidal behaviors, 93.8%, 12–15 years - 72.1%; 16–18 years old −74%. Positive attitude
and 3/ dialogue with media representatives. At the 1st Suicidology to body SH presents at 10–11 and 12–15 years: 34.4% and 35%.
Congress in Lodz in 2018, the participants signed the Declaration, Reduction of the indicator to 25% noted in 16–18 years. Substance
the cornerstone of Polish suicide prevention strategy. use (SU) is expressed in the older age group: 10.4% use tobacco
Conclusions.– The milestones of national suicide prevention strat- at 16–18 years; 4,5% - in 12–15 years and 3,1% - in 10–12 years.
egy have been reached due to networking experts, strengthened by They drink alcohol at the age of 16–18 - 35%, 12–15 years - 17.1%,
the representatives of Polish government. 10–11 years - 3.1%. Active interest in SU increases during the peri-
Disclosure of interest.– The authors have not supplied a conflict of ods 10–11 (2.91%) and 16–18 years (2.92%), at the age of 12–15
interest statement. it decreases to 2.61%. The maximum suicide risk was revealed in
12–15 years (2.86%), the minimum in 10–12 years (1.78%).
Conclusions.– Instrumental SH prevail in 10–11 years; in 12–15
E-PP1260
years the risk of suicide increases; at the age of 16–18, the use
High levels of PCR in patients that of psychoactive substances is increasing. Interest in instrumental
have committed a suicide attempt types of self-harm decreases at the age of 12–15 years against the
L. Gonzlez* , S. Trincado Robles background of increased risk of suicidal behavior.
Hospital de Zamudio, Psychiatry, Bilbao, Spain Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
Background and aims.– Some studies have published that patients

with intense autolytic ideation have higher PCR (protein C reac-
tive) levels than depressed patients with mild autolytic ideation
or control patients. Our aim is to describe the grade of inflamma-
tion that patients who have been interned in a Psychiatric Hospital
E-PP1262 care. Descriptive and logistic regression analyses were conducted

Aircraft-assisted pilot suicides in the to report variables related to not attend ARSUIC medical visit.
United States, copycat phenomenon Results.– A total of 66% (n = 117) finally attended to ARSUIC medical
visit. Patients with anxiolytics and that have committed previous
and september 11, 2001 suicide attempts were more likely to attend ARSUIC visit. On the
T. Laukkala1* , A. Vuorio2 , I. Junttila3 , R. Bor4 , B. Budowle5 , E.
contrary, patients with no previous suicide attempts, and those
Pukkala6 , P. Navathe7 , A. Sajantila8
1 Mehiläinen Kielotie Health Centre, Vantaa, Vantaa, Finland; 2
who have attempted suicide with overdose and precipitation were
those who less likely attend to the medical visit.
Mehiläinen Airport Health Centre, University of Helsinki, Department
Conclusions.– The number of patients that attended the ARSUIC
of Forensic Medicine, Vantaa, Finland; 3 University of Tampere,
medical appointment was higher in “La Princesa” hospital than
Fimlab Laboratories, Faculty of Medicine and Life Sciences, Tampere,
in other health care areas from Madrid (1). However, there are
Finland; 4 Royal Free Hospital, Centre for Aviation Psychology,
still high-risk suicide patients that are not being covered by the
London, United Kingdom; 5 Center for Human Identification,
ARSUIC program. It might be necessary to implement further
University of North Texas Health Science Center, Fort Worth, USA; 6
actions beyond a high-priority medical appointment so that people
Faculty of Social Sciences, University of Tampere, Tampere, Finland; 7
with suicide attempts receive the mental health care attention they
The Maitland Hospital, Maitland, Maitland, Australia; 8 University of
need.
Helsinki, Department of Forensic Medicine, Helsinki, Finland
interest statement.
Background and aims.– Pilot aircraft-assisted suicides are rare. There
is limited understanding of copycat phenomenon, defined as suici-
E-PP1264
dal behavior provoked by media exposure, among pilots. The aim
of this study was to evaluate the possible effect the September 11, Association between marital status
2001 terrorist attacs had on pilot AASs in the U.S. and death by suicide: age and sex
Methods.– Fatal aviation accidents in the National Transportation stratified analyses
Safety Board (NTSB) database were searched using the following C.Y. Li
search words: “suicide”, “murder-suicide” and “homicide-suicide”. College of Medicine, National Cheng Kung University, Department of
The timeline between September 11, 1996 and September 11, 2004 Public Health, Tainan, Taiwan R.O.C.
was analyzed. Only incidents in which NTSB reported the cause of Background and aims.– Marriage assists an individual in coping with
the fatal accident to be pilot suicide were included. stress because it provides insurance against adverse life events.
Results.– Fourteen pilot or co-pilot AASs were analyzed. The relative With increased number in single individuals, societal values toward
risk (RR) of the pilot AASs in all fatal accidents in the U.S. was cal- family and marriage have changed over time. Understanding the
culated in order to compare the one- two and three-year periods suicide risk associated with non-marriage is crucial in promoting
after the September 11 terrorist attacs with five years preceding the mental health of single persons. This study aims to examine
the event. The relative risk (RR) of a fatal general aviation aircraft the sex-age-specific effect of marital status on the risk of death by
accident being due to pilot suicide was 3.68 -fold (95% confidence suicide.
interval 1.04–12.98) during the first year after September 11, 2001 Methods.– This was a case-control design nested within all deceased
but was not statistically significantly elevated later. individuals age> = 20 years and registered in Taiwan’s Death Reg-
Conclusions.– This study showed an association, albeit not a deter- istry (TDR) in the period 2007–2013. Cases were victims of
minate causal effect of September 11, 2001 with pilot AASs. The suicide (n = 17,778), and controls were randomly selected with
copycat effect was present for one year after September 11, 2001. a case/control ratio of 1:10 from all individuals who died from
The causal factors behind this association remain unclear, but some non-suicide causes. Multiple logistic regression models, with
of these pilots with no data on previous psychiatric issues had adjustment for age, sex, and region/urbanization of residential
recent stressful events before the incident, such as legal or inter- areas, was used to assess the effects of marital status on the risk
personal difficulties. of suicidal death.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Compared to married persons, divorced (odds ratio
interest statement. (OR) = 2.57, 95% CI = 2.42–2.73) and unmarried (OR) = 1.46, 95%
CI = 1.40–1.54) individuals were found to significantly associate
with increased risks of suicidal death. Widowed shows no associ-
E-PP1263 ation with suicidal death (OR = 0.95, 95% CI = 0.90–1.01). The effect
Which patients are not being covered of divorce was most notable in 35–54-year women (OR = 3.01),
by the suicide prevention program followed by 20–34-year women (OR = 2.72), and 55–64-year men
arsuic in Madrid? (OR = 2.71). The corresponding figures for the effect of unmar-
I. Leal1* , M. Cabello2 , M.A. Romero-Rodriguez3 , L. Manzano3 ried were 35–54-year-old women (OR = 1.86), 35–54-year-old men
1 Hospital Universitario de la Princesa, Psychiatry, Madrid, Spain; 2 (OR = 1.81), and ≥65-year-old men (OR = 1.68).
Universidad Autonoma de Madrid, Psychyatry, Madrid, Spain; 3 Conclusions.– Divorced and unmarried individuals were at
Universidad Autonoma de Madrid, Psychiatry, Madrid, Spain increased risk of death by suicide. Younger women and older men
* Corresponding author. appear to be especially vulnerable to such adverse effect.
Background and aims.– Community of Madrid created a suicide pre- interest statement.
vention program called ARSUIC in 2014. ARSUIC program consisted
of offering to people that have attempted suicide (in less than seven
days) a mental health care visit. To our knowledge, it has not been E-PP1265
yet evaluated the patient’s characteristic that do not attend finally Risk for suicidal ideation in the
that specialized care appointment greatage study, a population-based
Methods.– A retrospective study consulting all the patients’ med- study in older age
ical records that attempted suicide between January 2016 and
M. Lozupone1* , M. Beghi2 , F. D’Urso3 , M. La Montagna3 , R.
February 2018 and visited the “La Princesa” hospital emergency
Sardone1 , M.R. Barulli1 , P. Battista1 , D. Seripa4 , A. Bellomo3 , F.
Panza1 , C.M. Cornaggia5 , G. Logroscino1
1 Neurodegenerative Disease Unit, University of Bari Aldo Moro, whereas only 0.7% of controls made an attempt after an average of
Department of Basic Medicine, Neuroscience and Sense Organs, Bari, 6 years. In samples of emerging adults and adults, suicidal ideation
Italy; 2 AUSL Romagna, Department of Mental Health, Ravenna, Italy; in ASD was reported to be between 31–50%. ASC diagnosis is an
3 Psychiatric Unit, University of Foggia, Department of Clinical and independent risk marker for suicide attempts, others risk factors
Experimental Medicine, Foggia, Italy; 4 Geriatric Unit & Laboratory of included: camouflaging, unmet support needs, non-suicidal self-
Gerontology and Geriatrics, Department of Medical Sciences, IRCCS injury, unemployment, and mental health problems. There are a
“Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy; 5 School lack of studies about protective factors in this clinical population.
of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy Conclusions.– Considering elevated rates of suicide in ASD adults
* Corresponding author. compared with their peers, this is an obvious area for further
research to try to recognize protective factors and implement pre-
Background and aims.– Risk factors for Suicidal Ideation in older ventive programs.
age are not clear. Strong measures of suicide risk are fundamen- Disclosure of interest.– The authors have not supplied a conflict of
tal for the development and evaluation of suicide prevention and interest statement.
treatment programs and for ongoing population-based research.
The aims are to calculate the rates of suicide ideation and to find
the demographic, psychiatric, social and cognitive characteristics E-PP1267
linked to suicidality. Suicide ideators vs attempters:
Methods.– We analyzed data on 1271 subjects aged 65 years
sociodemographic and clinical
and over (mean age 73.617 ± 6.341; 53,34% females) from the
population-based GreatAGE Study (Castellana Grotte, Sud-East differences
Italy). A single question from SCL-90R was administered to detect C. Mota Pinto1* , S. Malta vacas1 , A.R. Carvalho2 , D. Cruz1 , C. Klut2 ,
past (last month) suicide ideation and Semi-Structured Diagnos- M.J. Heitor1
1 Hospital Beatriz Ângelo, Psychiatry and Mental Health Department,
tic Interview for DSMIV-TR for Psychiatric diagnosis. Cognitive
functioning was assessed through a complete neuropsycholog- Loures, Portugal; 2 Hospital Beatriz Ângelo Hospital, Psychiatry and
ical battery. Self-reported material and social deprivation were Mental Health Department, Loures, Portugal
evaluated with Deprivation in Primary Care-Questionnaire (DiP-Q
Care). Social Dysfunction Rating Scale (SDRS) quantifies man’s dys-
Background and aims.– Introduction: Suicide is among the leading
functional interaction with his environment. APOE genotype was
causes of death worldwide. Globally, more than 800,000 people die
obtained for a subsample of 600 patients.
due to suicide each year. Unfortunately, despite increased preven-
Results.– The overall frequency of suicide ideation was 2.2%, without
tion efforts, suicide rates over the past several decades appear to
differences between genders and within age strata (p = .08). Suicide
be increasing. The presence of a psychiatric disorder is among the
ideation was significantly associated with depression (both early
most consistently reported risk factors for suicidal behavior.
and late-onset)(p = .000). The association increased with higher
Objectives: To provide sociodemographic and clinical characteri-
scores of GDS-30. There were not significant association with level
zation of psychiatric inpatients reporting either suicide ideation
of education, cognitive functioning (MCI, SCD, dementia), APOE
(SI) or a recent suicide attempt (SA). Moreover, it was intended to
genotype and deprivation (p>0.05). The association with social
both compare 1) SI and SA; 2) and, suicide attempts by deliberate
dysfunction (for SDRS cut-off>25) in the components of apathetic
self-poisoning (DSP) vs. violent methods.
detachment, dissatisfaction with leisure activity and work, anxiety
Methods.– Methods: For the purpose of this study, we included all
disappeared after adjusting for depression diagnosis.
patients with 18 years and older admitted to the Psychiatric Inpa-
Conclusions.– Depressive disorders should be considered for suicide
tient Unit of the Hospital Beatriz Ângelo, Portugal, between January
prevention in the elderly and Social dysfunction as an epiphe-
2017 and December 2017. Patients were divided in two groups:
nomenon.
suicide ideators and suicide attempters.
Results.– Results: A total of 106 admissions (58 ideators and
interest statement.
48 attempters) were identified. Attempters (compared to suicide
ideators) were more frequently male (p < 0,001), retired or unem-
ployed (p 0,015). Attempters who used violent methods (compared
E-PP1266
to those who used DSP) were more often male (p 0,013), and had
Autism spectrum disorders in adults significantly more frequent an ICD 10 F20-29 (psychosis) psychi-
and suicidal behaviours: a review atric diagnosis (p 0,001) and less frequently a history of non-suicidal
C. Machado self-injury (p 0,008).
Hospital Magalhães Lemos, psychiatry, Porto, Portugal Conclusions.– Conclusions: In our sample we found that male gen-
Background and aims.– Autism spectrum disorders (ASD) are der, history of drug use disorder and ICD 10 psychiatric diagnostic
common neurodevelopmental disorders characterized by persis- are major precipitants of suicide risk, which points those patients
tent deficits in social communication and social interaction and as great clinical concerns.
restricted, repetitive patterns of behavior, interest, and activities. Disclosure of interest.– The authors have not supplied a conflict of
Several large-scale studies found that individuals with ASD com- interest statement.
prised 7.3–15% of suicidal populations, a substantial subgroup.
The aims of this study are: to examine the prevalence of suicidal-
ity (ideation, attempts and complete suicide) among adults with E-PP1268
ASD, related demographic and clinical characteristics, and associ- A nationwide general practitioner
ated risk and protective factors.
training program to reduce suicide in
Methods.– A literature search was performed using Pubmed and
Cochrane Library databases. An initial search was performed using bulgaria: a non-randomized
the following terms: “autism” and “suicide” or “suicidal”. This controlled trial
search yielded a list of 136 articles. We selected 35 articles accord- T. Widding-Havneraas1 , H. Hinkov2 , Z. Zarkov2 , V. Nakov2* , R.
ing to our aims. Dinolova2 , P. Marinov3 , S. Harvey4 , P. Butterworth5 , A. Holte6 , A.
Results.– The only large-scale epidemiologic study of suicide Mykletun1
1 Norwegian Institute of Public Health, Mental Health and Suicide,
attempts in ASD reported that 3.9% of the ASD group made a
suicide attempt after an average of 3.6 years after enrollment, Bergen, Norway; 2 National Center of Public Health and Analyses,
Mental Health, Sofia, Bulgaria; 3 Mental Health Center “N. evaluate the relation between “Neuroticism”, depression and sui-
Shipkovenski”, Forensic Psychiatry, Sofia, Bulgaria; 4 Black Dog cide risk in both clinical and nonclinical sample.
Institute, Workplace Mental Health Research Program, Sydney, Methods.– 1043 subjects (410 patients and 693 students) were
Australia; 5 Australian National University, College of Health and tested in three regions of Europe: central Italy, northeast Italy
Medicine, Melbourne, Australia; 6 University of Oslo, Psychology, and eastern Austria. Different evaluation scales were applied:
Oslo, Norway Sociodemographic questionnaire, Columbia-Suicide Severity Rat-
* Corresponding author. ing Scale-B, Symptom-Checklist-90-Standard, Big Five Inventory,
International Statistical Classification of Diseases and Related
Background and aims.– The WHO recommends improving GP’s skills Health Problems (ICD-10).
in suicide risk management in order to reduce suicide rates. How- Results.– Data analysis demonstrated a correlation between “Neu-
ever, the evidence for effectiveness of this approach is at best roticism” and different suicide dimensions (Suicidal Ideation
limited. The aim of this study is to test if suicide rates can be reduced and Intensity of ideation: p value < 0.05; Suicidal Behavior: p
by providing such training to GPs, supported by information to the value < 0.01). Depression was highly related with suicide (p
public. value < 0.01) and “Neuroticism” in conjunction with depression
Methods.– Four regions of Bulgaria (population n = 5.5 million) were significantly increased the risk of suicide in psychiatric patients.
defined as intervention group, whereas the remaining two regions However, without the involvement of depression, “Neuroticism”
(population n = 1.5 million) as control group. GP’s, psychologists was a protective factor against suicidal ideation.
and social workers (n = 1 473) in the intervention region were Conclusions.– The association of neuroticism with suicidality is
engaged in an online training with exams, a 16-hour seminar during more complicated than has been previously described. The results
the period January to June 2016. The participation rate was 63.4%. of our study show that the positive relationship between “Neuroti-
The intervention region was also exposed to public campaigns with cism” and suicide is for the most part influenced by depression.
video clips in local and regional media. The population and the However, we could confirm our hypothesis by demonstrating that
GP’s were blinded for this controlled trial. The effectiveness of this “Neuroticism” played an important role in the triangular relation-
approach was measured with official data for completed suicides ship suicide -mental health -personality.
and suicide attempts and analysed with a difference-in-difference Disclosure of interest.– The authors have not supplied a conflict of
approach, testing the interaction between time (before/after inter- interest statement.
vention) and group.
Results.– We found that the intervention reduced completed sui-
cides (p < .001), but simultaneously also increased registrations of E-PP1270
attempted suicides (p < .001). Using online technologies in
Conclusions.– This is the first large-scale study that provides evi-
psychological counseling for suicide
dence for suicide prevention by training GP’s, which supports
WHO recommendations for suicide prevention. The intervention prevention
is scalable and relatively low cost. The intervention also produced E. Nikolaev* , V. Ivanov
an increase in registered suicide attempts, which may be due to Ulianov Chuvash State University, Social and Clinical Psychology
increased recognition and awareness. Department, Cheboksary, Russia
interest statement.
Background and aims.– Numerous various factors can influence
committing a suicide. Of special attention is a possibility to model
a person’s suicidal behavior via the internet. There is always such
E-PP1269
information on demand that may encourage suicides. On the other
Suicide and neuroticism: a hand, there is a constant grow in a number of internet resources
multicenter study aimed to help people in a crisis. Our objective was to find out pos-
A. Nardella1* , S. Stefa-Missagli2 , G. Giupponi3 , K. Davok4 , S.J. sible ways of getting a psychological assistance prior to a suicidal
Holasek5 , H.P. Kapfhammer2 , E. Rogante1 , I. Berardelli1 , K. attempt via the internet.
Andriessen6 , K. Krysinska7 , G. Falcone1 , D. Erbuto1 , H. Methods.– Methods include a qualitative analysis of accessible
Moujaes-Droescher8 , M. Pompili1 English and Russian websites that deal with suicide prevention.
1 Sapienza, University of Rome, NESMOS Department Neurosciences,
Results.– The analysis proved that all the resources have an open
Mental Health and Sense Organs Unit of Psychiatry, Sant’Andrea access for all who suffer from depression or find themselves in a
Hospital-, Rome, Italy; 2 Medical University, University Clinic for crisis situation. Judging from the content of the available material,
Psychiatry-, Graz-, Austria; 3 Südtiroler Sanitätsbetrieb, Clinic for the afore mentioned websites can inform about the risk factors, the
Psychiatry, Bolzano-, Italy; 4 Karl-Franzens-University, Institute of opportunities of getting an assistance, diagnose a degree of the risk,
Psychology-, Graz-, Austria; 5 Medical University, Institute of discuss existential sufferings, provide counsel in hardships, act as a
Pathophysiology and Immunology-, Graz-, Austria; 6 Centre for support group, and counsel a potential suicide’s relatives. There are
Mental Health, School of Population and Global Health, The University resources that target certain groups of people distinguished by the
of Melbourne, Parkville, Australia; 7 Centre for Primary Health Care same age, gender, job, social stratum or ethnic culture, etc. There
and Equity, University of New South Wales, Sidney, Australia; 8 are particular websites for mental health professionals with special
Karl-Franzens-University, Institute of Psychology, Graz, Austria educational programs and screening materials.
Conclusions.– Taking into consideration that more people get an
access to the internet in Russia and regarding the potentials of mod-
Background and aims.– Prior research consistently demonstrates
ern internet technologies in suicide prevention, we think it is quite
that neuroticism increases risk for suicidal ideation. However, the
promising to develop an accessible system of professional online
association between mental disorder, suicide risk and variables
psychological counseling for the people in a suicidal crisis.
related to personality, especially the “big five” personality fac-
tors (pleasantness, openness, neuroticism, conscientiousness and
interest statement.
extroversion) warrants clarification.
The aim of this multicentre study is to clarify the association of
neuroticism with suicidal ideation and attempted suicide and to
E-PP1271 and covered a large urban area for an extensive time period. Unfor-
Peculiarities of suicide mortality rates tunately, no additional information could be retrieved from the
in Kaluga region from 2003 to 2016 victims’ forensic records.
E. Nosova Conclusions.– Our data could imply a relative lack of prompt diag-
Kaluga Regional Psychiatric Hospital, Medical Rehabilitation, Kaluga, nosis and effective treatment of psychiatric disorders particularly
Russia in elderly males hospitalized for physical ilnesses in GH. Contin-
Background and aims.– The main feature of the suicide mortality uous education of non-psychiatric medical and nursing staff on
in Russia during the period 2003–2016 is decline of rates from psychopathology seems an obvious countermeasure.
36,1 to 15,76/100 000. Great differences of suicide mortality rates, Disclosure of interest.– The authors have not supplied a conflict of
religious, cultural, ethnical and economical diversity of regions, interest statement.
highlight the need for thorough investigation of this issue according
to the local context. E-PP1273
The detailed analysis of the suicidal mortality in Kaluga Region, Developing preventative intervention
searching for «trouble spots» on the regional map, identification of
«at-risk» groups for priority interventions.
support for adolescent self-harm in
Methods.– The retrospective longitudinal design has been schools: using a whole-system
employed using the mathematical statistics. approach to generate explanatory
Results.– Kaluga Region is one of the most economically advanced theory from interdisciplinary
territories of the Russian Federation with population of 1 012 156 perspectives for preventative
and Gross Regional Product 373,4 (2016, RUB). It takes 47 place
among all regions (2016) and shows the decline of suicide mortal-
intervention
R. Parker
ity levels from 30,1 to 14,8/100 000 (2003–2016). Over the period
Cardiff University, Decipher Centre for the Development and
considered male suicides exceeded female both on regional and
Evaluation of Complex Interventions for Public Health Improvement,
on federal level. In different years the male to female ratio varied
Cardiff, United Kingdom
from 4,1:1 (2009) to 6,8:1 (2005). The most vulnerable age groups
Background and aims.– Adolescent self-harm in Europe is a major
included 45–49 (11%) and 50–54 (10%) years. The difference in sui-
public health challenge. In the UK there are increasing rates in
cide mortality rates in urban and rural areas in 2003 (23,99 and
hospital admissions. Finding a solution to this issue requires a pre-
48,5/100 000) has been almost offset in 2016 (14.54 and 15,7/100
ventative intervention approach for young people which includes
000). Among 26 districts of the Region 14 demonstrated high levels
community-based delivery. Secondary schools are posited as key
of suicide mortality (more than 20/100 000, 2016).
settings where this type of support could be delivered. However
Conclusions.– The identified regional «trouble spots» highlights the
these sites are not neutral settings as they are imbued with the
importance of local prevention program development which is
school culture. This impact of the school context is not currently
going to be the important step to the National Prevention Strategy.
understood upon adolescent self-harm preventative intervention
support, nor the wider societal influences which schools reside
interest statement.
within. Little is known about what is acceptable and feasible for use
in schools. These points have not received sufficient attention up
E-PP1272 to now in preventative intervention development, and may offer a
way forward to finding a solution for the health topic of adolescent
Suicide victims in non-psychiatric self-harm.
wards of general hospitals: focus on a This paper therefore exposits the design and methods of a current
25 year sample from Greece research project to address the aforementioned issues. A socio-
A. Paraschakis1* , I. Boyokas2 ecological systems approach will generate explanatory theory from
1 Psychiatric Hospital of Attica “Dafni”, Department of General Adult interdisciplinary perspectives for preventative intervention in sec-
Psychiatry, Athens, Greece; 2 Ministry of Justice, Piraeus Department ondary schools in Wales. This work has been developed to address
of Forensic Medicine, Piraeus, Greece the need for action for the current public health challenge of ado-
lescent self-harm, in order to promote the health and well-being of
young people in secondary schools in Wales.
Background and aims.– Severe medical illness increases suicide risk Methods.– This paper exposits the design and methods of the cur-
due to comorbidity with psychiatric disorders, primarily depres- rent active research project.
sion. Suicides in the medical-surgical setting, albeit rare, are Results.– Interim results will be presented.
particularly traumatic. We aimed to highlight this topic, focusing on Conclusions.– Interim conclusions to be presented.
a 25-year (1992–2016) sample of suicide victims in Greece’s largest Disclosure of interest.– The authors have not supplied a conflict of
port city area (Piraeus). interest statement.
Methods.– Data were collected from the victims’ forensic records in
the Piraeus Department of Forensic Medicine (PDFM). PDFM cov-
ers an area of approximately 700,000 inhabitants, including 3 large E-PP1274
General Hospitals (GH). Adolescents at ultra-high risk of
Results.– During the period we studied, 19 out of 1178 suicides psychosis: suicidality across a
(1.6%) occurred in medical-surgical (non-psychiatric) wards; 17
males (89.5%), 2 females (10.5%), median age 62.7years (SD:14.1),
two-year longitudinal study
L. Pelizza1* , M. Poletti1 , S. Azzali1 , F. Paterlini1 , I. Scazza1 , S.
89.5% Greeks. Toxicological examinations were available for 17
Garlassi1 , L.R. Chiri2 , E. Semrov1 , A. Raballo3
cases: 2 (11.8%) were under psychiatric medications (just one was 1 Reggio Emilia Public Health-Care Centre, Reggio Emilia Department
receiving an antidepressant). Another 2 (11.8%) had consumed
of Mental Health and Pathological Addiction, Reggio Emilia, Italy; 2
alcohol prior to their death. Prevalent suicide method was, by far,
Bologna Public Health-Care Centre, Bologna Department of Mental
jumping from a height (17 cases/89.5%), followed by 1 case of hang-
Health and Pathological Addiction, Reggio Emilia, Italy; 3 University
ing and 1 of shooting by a firearm. Most suicides occurred during
of Perugia, Division of Psychiatry, Clinical Psychology and
June, September and November (4 each/21%) and in the years 2003
Rehabilitation, Department of Medicine, Perugia, Italy
and 2015 (3 each/15.8%). The study was the first of its kind in Greece * Corresponding author.
Background and aims.– Suicide risk in individuals at Ultra-High Risk Disclosure of interest.– The authors have not supplied a conflict of
of psychosis (UHR) has been poorly assessed in adolescence. How- interest statement.
ever, it is of obvious importance for clinical and prognostic care
reasons. In this study, we aimed to prospectively assess suicide risk
and behaviors in UHR help-seeking adolescents. E-PP1276
Methods.– We examined 112 help-seeking adolescents (13–18 Ten-year epidemiological study on
years, 50% males, 83.9% Caucasian) enrolled in the Reggio Emilia At- suicide attempts in Skopje, Republic
Risk Mental States (ReARMS) project and followed-up for two years.
of Macedonia
Specific items derived from the Comprehensive Assessment of At-
M. Polazarevska1* , K. Jordanovska1 , J. Petreska2 , G. Kalpak3
Risk Mental States (CAARMS - i.e. item 7.3 “Suicidality/Self-Harm”) 1 University Clinic of Psychiatry, University “Ss. Cyril & Methodius”,
and the Beck Depression Inventory-II (BDI-II - i.e. item 9 “Suicidal
Skopje, R. Macedonia, Department of Child and Adolescent
Ideation”) were used to assess suicide risk. Suicide attempts and
Psychiatry, Skopje, FYR Macedonia; 2 International Balkan University,
completed suicides were also recorded across two-year follow-up
Skopje, R. Macedonia, Faculty of Psychology, Skopje, FYR Macedonia;
assessment. 3 University Clinic of Psychiatry, University “Ss. Cyril & Methodius”,
Results.– Baseline assessment detected 40 UHR, 32 FEP (First-
Skopje, R. Macedonia, Department of Psychiatry, Skopje, FYR
Episode Psychosis) and 40 non-UHR/FEP adolescents. We found
Macedonia
that 67.5% of UHR adolescents had suicidal ideation, and 18.5% * Corresponding author.
to a severe degree (i.e. BDI item 9 score ≥ 2). Attempted suicide
before enrollment was higher in the UHR than in non-UHR/FEP Background and aims.– Suicide is a complex phenomenon with psy-
group (17.5% vs. 2.5%). BDI-II suicidal ideation severity was stable chological, social, biological, cultural and environmental factors
at 12-month follow-up and decreased at 24-month follow-up. involved.
Conclusions.– A high prevalence of suicidal ideation among UHR The aim of our study was to provide basic epidemiological data
adolescents was found and supports the routine monitoring of risk on suicide attempts that resulted in admission to the University
of self-injurious thinking and behavior in this at risk population. Clinic of Toxicology and Emergency Medicine in Skopje during 10-
Disclosure of interest.– The authors have not supplied a conflict of year-period (1999–2008). There is a lack of published information
interest statement. regarding suicide attempts in the Republic of Macedonia.
Methods.– Participants were 1683 patients from the territory of
Skopje, who attempted suicides and who were hospitalized in the
E-PP1275 University Clinic of Toxicology and Emergency Medicine in School
Suicidal ideation instability in patients of Medicine, Skopje during the period of ten years (1999–2008).
hospitalized for depression: an The following variables were included in the analysis: age, gender,
exploratory study using smartphone religion, method of suicide attempt and admission date. The results
were analyzed with the Statistic for Windows program, release 7.0.
ecological momentary assessment
Results.– A significantly higher number of suicide attempts were
E. Peters1* , L.Y. Dong1 , T. Thomas2 , S. Khalaj1 , L. Balbuena1 , N.
registered in females than in males from the territory of Skopje
Osgood2 , R. Bowen1
1 University of Saskatchewan, Psychiatry, Saskatoon, Canada; 2 during the period of 1999–2008. Men who attempted suicide
were older than women. Women of Christian religion affiliation
University of Saskatchewan, Computer Science, Saskatoon, Canada
* Corresponding author. attempted suicide more frequently than women of Muslim religion.
The greatest number of attempts was during the summer season.
Background and aims.– Suicidal ideation (SI) can fluctuate consid- The most common method of suicide attempt was intoxication with
erably over short periods of time. There is a lack of knowledge medications. tempts in the Republic of Macedonia.
regarding SI instability (SII) in patients with depression. This study Conclusions.– Our study has shown that attempted suicide rate has
used ecological momentary assessment (EMA) to explore the cor- had a stable trend over the last decade. It has also shown female pre-
relates of SII in adults hospitalized for depression and SI. dominance of suicide attempts with a greater number of attempts
Methods.– Thirty-nine adult patients hospitalized voluntarily for during the summer months. There is a need for intervening strate-
depression (unipolar or bipolar) and SI were recruited. Smart- gies to be targeted at younger females.
phones with visual analogue scales were used to rate current Disclosure of interest.– The authors have not supplied a conflict of
depressed mood, anger/irritability, feeling socially connected, and interest statement.
SI three times a day for up to 14 days throughout hospitalization.
Intensity was defined as the mean of all ratings. Instability was
defined as the mean squared successive difference between rat- E-PP1277
ings. The Beck Depression Inventory (BDI), Beck Scale for Suicide Alcohol consumption and gender gap
Ideation (BSS), and Affective Lability Scales (ALS) were completed in suicide mortality in Europe
at baseline and study exit. Y. Razvodovsky* , S. Kandryczyn
Results.– SII was moderately correlated with SI intensity, depressed Grodno State Medical University, Pathological Physiology, Grodno,
mood instability, and social connection instability. Social connec- Belarus
tion instability was not associated with SII after controlling for * Corresponding author.
depressed mood instability. Baseline ALS, BDI, and BSS scores were
not significantly associated with SII, nor were BDI and BSS change Background and aims.– In most countries, suicide rates are sig-
scores. Participants with multiple past suicide attempts experi- nificantly higher for men compared to women, despite women
enced greater SII, but participants with one past attempt did not engaging more frequently in suicide attempts. The gender gap in
differ from participants without past attempts. suicide mortality is particularly high in the countries of Eastern
Conclusions.– EMA effectively captures SII in hospitalized patients. Europe. Some researchers attribute the suicide-gender paradox in
SII is associated with EMA-derived depressed mood instabil- Eastern European countries to harmful drinking. This study aims to
ity, although mood instability questionnaires may not accurately test the alcohol-related hypothesis of the suicide-gender paradox
predict SII during hospitalization. More research examining the sig- in the countries of Eastern Europe.
nificance of SII is warranted, particularly in relation to future suicide Methods.– The study was based on death statistics (from 2010 to
attempts and hospitalizations. m2014) accumulated in European mortality database (MDB). The
gender gap in suicide mortality in 45 European countries was cal-
culated. The comparison in the gender gap was made between the accident has had a significant long-term impact on psycholog-
Western (n 21) and Eastern (n 24) European countries (t-test). ical well-being of the affected population. In particular, the rate of
Results.– Across the whole period the average gender gap in sui- suicidal behavior has increased dramatically among the exposed
cide mortality for Western and Eastern Europe was 3.8 ± 0.32 and population. At the same time, little epidemiological information
4.9 ± 0.35 respectively, while the average level of alcohol consump- about parasuicidal individuals is available. This study was design
tion per capita was 1.8 ± 0.18 and 3.1 ± 0.35 litres respectively. The to extend our understanding of suicidal behavior by examining
results of the correlation analysis indicate statistically significant urban-rural differences in the sociodemographic and mental health
relationship between alcohol consumption per capita and gender characteristics of female suicide attempters in the region affected
gap in suicide mortality in Eastern Europe (r = 0.58; p = 0.001). The by Chernobyl nuclear disaster.
results also indicate that there is no statistically significant rela- Methods.– We interviewed 207 female suicide attempters (137
tionship between alcohol consumption per capita and gender gap urban residents (UR) and 70 rural residents (RR)) received treat-
in suicide mortality in Western Europe. ment at Gomel regional psychiatric hospital (Belarus).
Conclusions.– The outcomes of this study suggest a positive relation- Results.– The most important risk factors identified were younger
ship between population drinking and gender gap in suicides in the age (18–29), being single (71.7% of RR and 59% of UR), being unem-
countries of Eastern Europe. Alcohol appears to play an important ployed (35% of RR and of 34.5% UR), having mental disorders (100%
role in the high gender gap in suicide mortality in this region. of RR and 96.7% of UR), having previous suicide attempts (36.7% of
Disclosure of interest.– The authors have not supplied a conflict of RR and 16.8% UR). The most frequent diagnoses were mental dis-
interest statement. orders due to psychoactive substances use (43.3% of RR and 37% of
UR). The prevalence of alcohol dependence was higher among RR
compared with UR (30% vs. 20.4%). Consumption of alcohol at the
E-PP1278 time of the parasuicidal act was reported more commonly by RR
Correlates of suicidal bahavior among than by UR (48.3% vs. 27.3%).
alcohol-dependent men Conclusions.– These findings are consistent with previous research
Y. Razvodovsky indicating a causal role for mental health problems and alcohol
Grodno State Medical University, Pathological Physiology, Grodno, abuse in suicidal behavior.
Belarus Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– Alcohol dependence (alcoholism) is asso- interest statement.
ciated with a considerable risk of suicidal behavior. Accumulated
evidence suggests that a lifetime diagnosis of alcohol dependence
is a major risk factor for attempted or completed suicide. In rela- E-PP1280
tion to this, it is crucial to investigate the risk factors of suicidal Alcohol as a contributor to the gender
behavior among alcoholics in order to prevent suicide attempts gap in suicides in Russia
and completions among this subgroup. This study seeks to iden- Y. Razvodovsky
tify risk factors of suicidal behavior among alcohol-dependent men. Grodno State Medical University, Pathological Physiology, Grodno,
The present study also aims to determine the differences between Belarus
alcohol-dependent suicide attempters and completers. Background and aims.– Across most countries, suicide rates are
Methods.– The sociodemographic and mental health characteris- significantly higher for men compared to women, while women
tics of 117 male alcohol-dependent suicide attempters and 99 male typically have higher rate of suicidal attempts. The gender differ-
alcoholics who commit suicide were investigated. ence in the suicide rates is particularly large in the Eastern European
Results.– Alcohol-dependent men, who attempt or complete suicide countries. In present study we will test the hypothesis of the close
are characterized by poor social support, living along, interpersonal aggregate level link between alcohol consumption and gender gap
conflicts, unemployment, psychiatric comorbidity. Results show in suicide mortality rates in Russia using data on sex-specific sui-
that, compared with suicide attempters, suicide completers were cide rates and alcohol consumption per capita between 1980 and
older (40 vs. 32.1), unmarried (43.4 vs. 33.3%), unemployed (63.6 2010.
vs. 46.2%). Consumption of alcohol at the time of suicidal behav- Methods.– Time-series analytical modeling techniques (ARIMA)
ior was reported more commonly by suicide completers (84.8 vs. were used to examine the relation between the gender gap in sui-
70.1%). Positive blood alcohol cases were found more frequently in cide mortality and trends in alcohol consumption per capita.
suicide attempters age 18–29 (91.9%) and suicide completers age Results.– The gender gap in suicide mortality decreased substan-
30–39 (93.3%). tially between 1984 and 1986, with the gender gap fell to an all-time
Conclusions.– Suicide attempters and completers were similar on low of 3.8, than jumped sharply between 1990 and 1994. From
most sociodemographic variables. However, suicide completers 1995–1998 there was a fall in the gender gap of before it again rose
were more likely to use alcohol before suicidal act. The acute alcohol between 1998 and 2001, reaching an all-time high of 6.6, and then
intoxication is a proximal risk factor for suicidal behavior among started to decrease. According to the results of time-series analysis,
alcohol-dependent men. alcohol consumption is a statistically significant factor associated
Disclosure of interest.– The authors have not supplied a conflict of with gender gap in suicide mortality in Russia. The results of the
interest statement. analysis also suggest that alcohol-attributable fraction of gender
gap ranged from 26,3% (30–44 age group) to 47,2% (44–59 age
group).
E-PP1279 Conclusions.– The outcomes of this study provide indirect support
Urban-rural differences in the for the hypothesis that alcohol is a major contributor to the high
correlates of female parasuicide in the gender gap in suicide mortality and its dramatic fluctuations in
Russia during the last few decades.
regions affected by chernobyl nuclear
disaster
Y. Razvodovsky
Grodno State Medical University, Pathological Physiology, Grodno,
Belarus
Background and aims.– Chernobyl nuclear reactor accident was the
greatest technological disaster in history. There is evidence that
E-Poster Presentation: Suicidology and suicide Results.– During the study period, a total of 24 335 suicide attempts
prevention - Part IV by self-poisoning including 679 cases of successful suicide were
reported, with an average of 716 cases per year. More than two-
thirds of the cases (70.7%) were females with a female-male ratio
of 2.4. The average age of the patients was 24.6 ± 9.9 years. Most vic-
E-PP1281 tims were adolescents and young adults aged 15-24 years (56.4%).
Parkinson’s disease: risk factors and For this age group, the number of suicide attempts is 30 times
prevalence of suicidal ideation and higher than that for successful suicides. According to the results,
suicide women make 2.7 times more suicide attempts than men. The drugs
R. Guedes1* , R. Curral2 , R. Coelho3 , C. Silveira1 were the primary means employed by victims (50.6%), followed by
1 Centro Hospitalar Universitário São João, Serviço de Psiquiatria- pesticides (31.1%). The poisoning symptoms were varied, depend-
Clínica de Psiquiatria e Saúde Mental, Porto, Portugal; 2 Centro ing on the toxins involved, the quantity of substance ingested and
Hospitalar Universitário São João, Serviço de Psiquiatria- Clínica de the delay before treatment.
Saúde Mental, Porto, Portugal; 3 Centro Hospitalar Universitário São Conclusions.– During their hospitalization, suicide attempters
João, Clínica de Psiquiatria e Saúde Mental, Porto, Portugal should receive careful medical and psychiatric supervision to avoid
* Corresponding author. the risk of recurrence.
Background and aims.– Parkinson’s disease (PD) is a common neu- interest statement.
rodegenerative disease of the Central Nervous System, primarily
affecting the motor system. It’s a chronic disabling disease that
mainly affects the elderly and is linked to a higher prevalence of E-PP1283
depression. Suicide is a major cause of death in PD patients and its Adolescent suicide and attempted
relation to depression is unquestionable. suicide: an unresolved clinical need
This work aimed to review the existing literature on the risk fac- G. Hernandez-Santillan1* , S. Ruiz-Murugarren2
tors for suicide, prevalence of suicidal ideation and suicide risk in 1 Psiquiatrist trainee, Psychiatry, Madrid, Spain; 2 Principe de Asturias
patients with PD. University Hospital, Urgency’s Psychiatry Room, Madrid, Spain
Methods.– The Medline database through the Pubmed search * Corresponding author.
engine was used with the following keywords: “parkinson’s dis-

Background and aims.– Suicide is the second leading cause of death
ease”, “suicide”, “depression”.
globally among young people aged 15–29 years. Attempted suicide
Results.– Male sex, existence of any comorbid psychiatric disor-
is around 10–100 times more common than suicide. Although many
der, particularly depression, higher L-dopa dosage, upper extremity
strategies have been developed, there is observed an increase in
onset of motor symptoms or generalized onset of motor symptoms
prevalence rates. Hence, the prevention of adolescent suicide is “an
and subthalamic nucleus deep brain stimulation are important risk
unresolved clinical need”.
factors for suicide in PD patients. About one-third PD patients have
Methods.– Literature review and description of local statistics.
suicidal ideation. Comorbid psychiatric disorders (mainly depres-
Results.– The epidemiology of risk factors has produced a large
sion), more than PD-related disease variables, were associated with
body of causal knowledge that is eminently individual. However,
suicidal ideation. Suicide risk in PD patients is approximately 2
currently we are looking at the growth of an integrative conception
times higher than that in the general population.
of epidemiology, which some have called multilevel epidemiology,
Conclusions.– A careful analysis of the factors that may contribute to
and which considers that disease phenomena respond to causal
the increased risk of suicide in PD patients is highly recommended.
schemes with determinants that act at different levels, molecular,
Early diagnosis and treatment of depression in PD is essential not
individual and population, interacting in complex hierarchical
only to improve the quality of life of patients but can also contribute
networks. Thus, one of the major risk factors for youth suicide
to a reduction of the suicide risk.
is the presence of a diagnosable psychiatric disorder, especially
affective disorder and borderline personality disorder. Further-
interest statement.
more, there are: psychotic disorders, substance abuse, addiction to
new technologies, coming from broken families, bullying, etcetera.
In a Spain Urgency Room, an increase in the rate of visits of
E-PP1282
adolescents by self-harm or suicide attempts has been observed
Suicide attempts by self-poisoning in in 15% each year during 2014-2018, which has triggered a big
Morocco: the epidemiological interest in investigating associated factors in local population by
evidence pediatricians and psychiatrists.
L. Amiar1 , H. Hami2* , F. Hadrya2 , N. Rhalem3 , A. Aarab1 , A. Conclusions.– Suicide is an unnecessary death, even more when it
Mokhtari2 , A. Soulaymani2 , R. Soulaymani-Bencheikh3 occurs in earlier stages of life. The knowledge of ecology and social
1 Faculty of Science and Techniques, Abdelmalek Essaadi University, variables provides valuable information for making-decisions by
Tanger, Morocco; 2 Laboratory of Genetics and Biometry- Faculty of clinicians, managers, politicians and pedagogues. Interventions by
Science, Ibn Tofail University, Kenitra, Morocco; 3 Moroccan Poison social services and neighbor’s communities are also important.
Control, Center, Rabat, Morocco Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– Suicide is a major hidden public health

problem around the world. According to WHO estimates for the E-PP1284
year 2020 and based on curent trends, approximately 1.53 million Specificity of crisis thinking of
people will die from suicide, and 10–20 times more people will
attempt suicide worldwide. The aim of this study is to determine
adolescents with borderline mental
the epidemiological characteristics of deliberate self-poisoning in disorders
Morocco. D. Kolomytsev* , Y. Drozdovsky
Methods.– This is a descriptive retrospective study of intentional Omsk State Medical University, Department of Psychiatry and
poisoning cases, reported between 1980 and 2013 to the Moroccan Medical Psychology, Omsk, Russia
Poison Control Center.
Background and aims.– One of the problems of teenage suicidal- Results.– The results reveals significant correlations (Spearman’s
ity is the formation of a crisis thinking stereotype, which at some rho, p < 0,05) of VSS subscales with oxidative stress and inflam-
future date, when the crisis is repeated, along with the experience matory biomarkers depending on the recent presence of suicide
of overcoming the fear of pain, significantly increases the risk of a activities and risk factors. Therefore the present study shows
lethal attempt. Crisis cognitive-behavioral therapy is aimed at the the associations between suicide risk assessment based on phe-
transformation of crisis thinking. nomenological indicators and biochemical variables.
The aim of the study is to develop of differentiated tactics of crisis Conclusions.– The phenomenological suicide risk assessment tools
therapy for adolescents with borderline mental disorders (BMD) may play an important role in the clinical suicide prevention. Fur-
based on specificity of their crisis thinking. ther clinical and theoretical implications are being discussed.
Methods.– 122 adolescents aged 14–17 with BMD and with sui- Disclosure of interest.– The authors have not supplied a conflict of
cidal ideation, tendencies, or committed a suicide attempt were interest statement.
included into the study. The adolescents were divided into 3 clin-
ical groups: with a depressive episode, with reactions to stress
and adjustment disorders, with emerging personality disorders. E-PP1286
The cognitive biases, metaprograms, motives and sense of suicidal Learning from the past, towards new
behavior were revealed. Correlation of these variables was studied horizons - findings from the Swedish
during the factor analysis.
register database of adverse events
Results.– 8 factors were distinguished that were interpreted as
(1) self-confidence, (2) emotional resignation, (3) globality, (4) (Nitha)
attention to shortcomings, (5) decisiveness, (6) transferring respon- M. Rex PhD student-Quality* , M. Dellepiane, C. Boldt-Christmas, E.
sibility to others, (7) dramatic nature, (8) cognitive weakness. von Hausswolff, T. Nordin, T. Brezicka
Clinical groups differed significantly in the average rank of 1, 2, 6–8 General Psychiatry Clinic, Sahlgrenska University Hospital,
factors. Furthermore, the ranks of factors varied considerably with Gothenburg, Sweden
alternative variants of the crisis severity: ideations and tendencies
- by factors 2, 8; tendencies and attempts - by factors 2, 4, 5. Background and aims.– Retrospective analysis after suicide is use-
Conclusions.– Crisis thinking of adolescents has specificity associ- ful for understanding systematic risk situations and prevent future
ated with BMD. Some features of crisis thinking can be considered events. Nitha is a Swedish database for adverse events and root
as pro- and antisuicidal factors and targets for crisis psychotherapy. cause analyses, offering good opportunities to learn from previous
Disclosure of interest.– The authors have not supplied a conflict of incidents.
interest statement. Objectives.– To identify common patterns among suicides commit-
ted in Sweden between 2014 and 2018:
• Classify causal factors and measures at micro and meso level.
E-PP1285
• Categorize them regarding sociodemographic, diagnostic, orga-
Phenomenology of suicide in terms of nizational parameters.
brain chemistry in the group of • Assess which of the most common measures could be effective
psychiatrically hospitalized patients in a preventive perspective.
T. Koweszko1* , J. Gierus1 , A. Zalewska2 , M. Maciejczyk3 , N. Methods.– 218 included cases, registered in Nitha between 2014
Waszkiewicz4 , A. Szulc1 and 2018 from all over Sweden. We identified key features such as
1 Medical University of Warsaw/Faculty of Health Sciences, Clinic of previous suicide attempt, method of suicide, documented health
Psychiatry, Warsaw/Pruszków, Poland; 2 Medical University of care plan, social and living conditions, deviations in the healthcare
Bialystok, Department of Restorative Dentistry, Białystok, Poland; 3 process. Possible modifications in the system which could give a
Medical University of Bialystok, Department of Physiology, Białystok, more effective suicide prevention have been summarized.
Poland; 4 Medical University of Bialystok, Department of Psychiatry, Results.– Partial results have been obtained, complete results will
Department of Psychiatry, Poland be provided in March 2019.
* Corresponding author. Conclusions.– Understanding possible deviations in the system can
help to improve the organization on a meso perspective and give
Background and aims.– There are studies providing evidence for more information about important clinical aspects involved in
suicide associations with inflammation and oxidative stress. The the suicidal process. Nitha is an important source for identifying
assessment of suicide risk based on phenomenological variables common patterns regarding suicide in Sweden and improving psy-
is an area not well explored. The present study presents relation- chiatric care for suicidal patients on a national level.
ship between attitudes towards suicide and oxidative stress and Disclosure of interest.– The authors have not supplied a conflict of
inflammatory biomarkers in the group of psychiatrically hospital- interest statement.
ized patients.
Methods.– The study comprised of 59 patients aged 18-65 who
were hospitalized in the Clinic of Psychiatry of Faculty of Health E-PP1287
Sciences, Medical University of Warsaw, Poland. The psychologi- Do affective temperaments predict
cal assessment included the Verbal Suicide Scale (VSS) providing
suicide attempts in patients suffering
data on attitudes toward suicide. Blood specimens were taken to
measure the levels of oxidative stress biomarkers: catalase (CAT), from depression?
superoxide dismutase (SOD), glutathione peroxidase (GPx), ferric I. Ristić1* , M. Jovicic2 , D. Hinic3
1 University of Belgrade, Faculty of Medicine, Epidemiology, Belgrade,
reducing ability of plasma (FRAP), Trolox equivalent antioxidant
capacity (TAEC), total oxidant status (TOS), oxidative stress index Serbia; 2 Faculty of Medical Sciences, Neuroscience, Kragujevac,
(OSI), advanced glycation end-products (AGEs), advanced oxidation Serbia; 3 Faculty of Science, Psychology, Kragujevac, Serbia
protein products (AOPP), protein; and inflammatory biomarkers:
interleukin IL-1 and IL-6. The subjects were divided into groups Background and aims.– Expression of any temperament trait other
depending on the presence of recent suicidal acts and suicide risk than the hyperthymic temperament has been found to be a risk
factors: self-mutilations, impulsiveness, alcohol/psychoactive sub- factor for future suicide attempts in psychiatric patients. A diag-
stance misuse and aggression. nosis of mood disorder has so far shown only limited predictive
value for suicidal behavior, making evaluation of affective temper- stress and relieved in its absence. Childhood physical neglect may
aments even more valuable when assessing risk factors for suicide. impair the ability to self-regulate thoughts and emotions. Future
The aim of our study was to evaluate affective temperament traits studies should elaborate on these associations in larger samples
in depressive patients, with and without previous suicide attempts. and different populations.
Methods.– A total of 251 patients diagnosed with major depressive Disclosure of interest.– The authors have not supplied a conflict of
episode (F32) or recurrent depressive disorder (F33) were divided interest statement.
into two groups - one with previous suicide attempts (168), and
the other without previous suicide attempts (83). They filled out
a sociodemographic questionnaire and the Serbian version of the E-PP1289
Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Treatment in nursing homes for
Autoquestionnaire (TEMPS-A). This scale separates 6 temperament suicidal ideation in elderly people
traits: depressive, cyclothymic, hyperthymic, irritable, anxious- C. Rodríguez Gómez-Carreño* , E. Segura Escobar
cognitive and anxious-somatic. 1 Hospital General Universitario Ciudad Real, Psychiatry, Ciudad Real,
Results.– After including affective temperaments in binary logis- Spain
tic regression analysis, our model correctly classified 70.9% of the * Corresponding author.
cases by suicide attempt, with depressive and irritable tempera-
ments being the only important predictors (2 = 38.092, p < .01). Background and aims.– Suicide is a frequent phenomenon in the
The model predicted between 14 and 20% of variance. Patients with geriatric population, assuming a proportion of 35% over the total of
depressive (OR = 5.957, p < .01) and irritable (OR = 4.377, p < 0.1) suicides, and constituting a Public Health problem. Associated with
temperaments were more likely to belong in the group of patients age, there are other important factors such as widowhood, drinking
with previous suicide attempts. alcohol and the recent institutionalization that should be important
Conclusions.– Prominent depressive or irritable affective tempera- when dealing with this type of patients. Providing strategies for
ments are characteristics of patients suffering from depression and the treatment of suicidal behavior in this population is necessary
risk factors that should be taken into consideration when assessing to identify and improve this important problem.
risk of suicidal behavior in these patients. Methods.– In our health area, the following interventions are carried
Disclosure of interest.– The authors have not supplied a conflict of out: Talks addressing suicidal behavior in the residential environ-
interest statement. ment to the staff of the center. Talks for assistance from relatives
and residents. Practical exercises and debate questions about the
approach to suicidal behaviors. Participation of nursing home staff:
E-PP1288 Primary Care Physicians, Occupational Therapists, Social Workers,
Childhood physical neglect and Nursing, Nursing Assistants. Satisfaction survey is administered
affective instability predict suicidal after the completion of the courses.
Results.– General satisfaction by the staff of retirement homes and
ideation variability in suicide
family.
attempters with borderline Evaluation of epidemiological data on suicide in our mental health
personality disorder area.
M. Rizk1,2* , T.H. Choo3 , H. Galfalvy3 , M. Oquendo4 , B. Stanley1 Conclusions.– The training actions in retirement homes help to
1 Columbia University, Department of Psychiatry, New York, USA; 2 make visible an important problem such as suicide. There is fear
New York State Psychiatric Institute/Columbia University, Molecular or ignorance of how to deal with this problem. Organizing courses
Imaging and Neuropathology Division, New York, USA; 3 Mailman for staff and family members improves the quality of life and expe-
School of Public Health, Columbia University, Biostatistics, New York, rience in nursing homes.
USA; 4 Perelman School of Medicine, University of Pennsylvania, Disclosure of interest.– The authors have not supplied a conflict of
Psychiatry, Philadelphia, USA interest statement.
Background and aims.– Suicidal ideation (SI) predicts future suicide E-PP1290
attempts, but little is known about its dynamics. SI can be per-
Grades of hematopoietic distress in
sistent with stable severity but also may be highly variable, with
sharp increases and a relatively quick decline. We posit a model in major depressive disorder patients
which SI variability represents a distinct pathway toward suicidal associated with suicidal attempt
behavior. We examined two factors that may predict SI variability A. Velasco1 , P. Martínez-Botía2 , J. Rodríguez-Revuelta3 , I. Abad3 , L.
in suicide attempters: childhood trauma and affective instability, De la Fuente-Tomás1 , T. Arias4 , M. Muñoz-Turillas5 , L. Gutiérrez2 ,
both of which are associated with increased suicide risk. M.P. Garcia-Portilla6 , J. Bobes6 , P.A. Sáiz Martinez6*
1 Dept. of Medicine, Area of Psychiatry, University of Oviedo –
Methods.– Participants included 52 females with borderline per-
sonality disorder and histories of a mood disorder and at least one CIBERSAM Spain, Department of Psychiatry, Oviedo, Spain; 2 Platelet
past suicide attempt. We used the childhood trauma questionnaire Research Lab, ISPA, Dept. of Medicine, Area of Medicine, University of
(CTQ) to assess early life abuse/neglect, and the affective lability Oviedo, Oviedo, Spain; 3 Servicio de Salud del Principado de Asturias,
scale (ALS) to quantify mood instability. SI variability was assessed SESPA, Dept. of Medicine, Area of Psychiatry, University of Oviedo,
over one week through ecological momentary assessment (EMA) Oviedo, Spain; 4 Centro Comunitario de Sangre y Tejidos de Asturias,
administered 6 times daily. The associations among SI variabil- Centro Comunitario de Sangre y Tejidos de Asturias, Oviedo, Spain; 5
ity and scores on the CTQ and ALS were examined using separate Platelet Research Lab, ISPA, Centro Comunitario de Sangre y Tejidos
longitudinal mixed-effects regression models. de Asturias, Oviedo, Spain; 6 Servicio de Salud del Principado de
Results.– ALS (ˇ = 0.0100, Z = 3.19, p = 0.0014) and physical neglect Asturias, SESPA, Dept. of Medicine, Area of Psychiatry, University of
subscale of CTQ (ˇ = 0.0467, Z = 2.83, p = 0.0047) predicted SI vari- Oviedo, CIBERSAM, Oviedo, Spain
ability. Furthermore, physical neglect and ALS were correlated
(Spearman’s r = 0.346, p = 0.021). CTQ total and other subscales
Background and aims.– Major depression (MDD) is the psychiatric
scores were not associated with ALS or SI variability.
disorder with higher prevalence amongst individuals with suicidal
Conclusions.– Frequent mood changes are significantly distressing
behavior (SB), increasing the risk of suicide by 20-fold. Inflamma-
and may be associated with fluctuating SI, activated in times of
tion biomarkers, such as the neutrophil-lymphocyte ratio (NLR)
have been reported to be increased in mood disorder patients. Disclosure of interest.– The authors have not supplied a conflict of
Recent data suggest a possible role of the immune system in the interest statement.
pathophysiology of SB. Aim: To examine hematopoietic parameters
in MDD patients, with or without suicidal attempt (SA).
Methods.– A complete blood count was performed from ninety- E-PP1292
eight subjects that were assigned to three clusters, based on ad Sites of autodestructive content in the
hoc protocol including sociodemographic and clinical data and the Russian-language segment internet
Hamilton Depression Rating Scale (HDRS). Statistical analysis was S. Igumnov1 , H. Shamarova2*
done using SPSS platform. 1 Institute of Psychology, Belarusian State University named after
Results.– As previously described, MDD patients presented ele- M.Tank, Centre for Children Rights Protection, Clinical Psychology,
vated NLR, and increased platelet counts (PLTs) with reduced mean Professor, Leading Researcher, Minsk, Belarus; 2 Institute of
platelet volume (MPV), suggesting reactive secondary thrombo- Psychology, Belarusian State University named after M.Tank, Clinical
cytosis. These values were more pronounced in concurrence with Psychology, Postgraduate Student, Minsk, Belarus
SA. However, independently of concurrence with SA or not, MDD * Corresponding author.
patients presented increased Red Blood Cell Distribution Width
(RDW), indicative of anisocytosis potentially linked to anemia. Cor- Background and aims.– In 2016 in Belarus and Russia there was an
relation of parameters (i.e. red blood cell counts (RBC) vs RDW, or increase of suicides among adolescents compared to the previous
PLTs vs MPV) in MDD patients, did not adjust to the correlations in year. In the mass media one of the reason of increase suicides was
control subjects, suggesting subjacent hematological distress. called the activation of “death groups” in social networks.
Conclusions.– Grades of hematopoietic distress and inflammation Methods.– A content analysis of suicidal data was carried out in
associate with concurrence with SA in MDD. Hematopoietic distress Google, Yandex and Mail.ru, the most popular search engines on
could be underlining the basis for systemic alterations, including the Runet; as well as materials posted in the most popular social
those affecting the immune response and inflammation. How these networks of the Russian-language Internet – “Vkontakte”, Facebook
hematological arms regulate each other in the context of mood and “Odnoklassniki”.
disorders remains to be elucidated. Results.– Data on the “epidemic” of teenage suicides are untrue.
Disclosure of interest.– The authors have not supplied a conflict of The dependence of the increase in the number of teenage suicides
interest statement. on the existence of “death groups” to date is a phenomenon of
the media and the QMS. At the level of evidence-based scientific
research, this dependence has not yet been confirmed. Simulated
E-PP1291 suicides or information about them provide teenagers with a model
The impact of unemployment in of behavior that reduces internal prohibitions on suicide. In the
suicide attempts and the role of Russian-speaking segment of the Internet there is both content of
information-prevention orientation, and destructive content.
protecting and precipitating factors
Conclusions.– Prevention of suicidal behavior should be built as a
R.P. Sant’angelo1* , V. Storbini2 , M. Bolondi3 , F. Sarchione4 , M.
system that includes preventive measures and measures to iden-
Pacetti5 , I. Piretti1 , G. Giannini1 , R. Raggini1 , F. Ambrosini6
1 Ausl Romagna, Mental Health, SPDC, Hospital Maurizio Bufalini, tify and operational psychological and educational correction of the
unfavorable development of crisis conditions, including develop-
Cesena, Italy; 2 University of Bologna, Psychiatry, Bologna, Italy; 3
ment of anti-suicidal sites, development of “anti-suicidal games”,
University of Modena, Psychiatry, Modena, Italy; 4 University of
providing communication with adolescents as well as control and
Chieti, Psychiatry, Chieti, Italy; 5 Ausl Romagna, Mental Health, CSM,
socio-psychological examination of the nature of reports of suicides
Forli, Italy; 6 University of Bologna, Faculty of Psychology, Cesena,
in the media.
Italy
interest statement.
Background and aims.– Recent studies found a correlation between
the growing incidence of suicides and the increased rate of unem-
ployment. However, it is still unclear if the unemployment is only E-PP1293
a precipitating factor which can be affected even by other aspects Association of BDNF serum levels and
or if it is the main cause of the attempts. genotype (VAL66MET) with suicidal
The study aims to examine the impact of the occupational status behavior in older adults from a
in suicide attempters, considering other potential precipitating or
tertiary care psycho-geriatric center
protective factors.
Methods.– A sample of 282 suicide attempters was recruited in of India
six different emergency services. Two groups of 141 unemployed A. Sonal* , S. Srivastava
(U) and 141 employed (E) individuals were selected. Both U and King George’s Medical University, Geriatric Mental Health, Lucknow,
E were composed of 74 females and 67 males matched for age India
(mean age = 41.89, SD = 10.81). The following data were collected:
objective lethality, consideration of lethality, intentionality, pre- Background and aims.– Ever increasing rate of suicide in late life is
vious suicide attempts, alcohol abuse, marital status, diagnosis. a matter of concern not only for developed countries but also for
Chi-squared tests were used to compare U and E. developing countries like ours. Plenty of literature has focused on
Results.– E tend to consider higher than U the lethality of the suicide multivariate risk factors for suicide and its etiology, but the exact
attempt, regardless of the marital status. U tend to attempt suicide mechanism leading to suicide or suicidal behavior is still fuzzy. The
during an alcohol abuse episode and to exhibit more frequently involvement of neural plasticity and the mediation of its effect by
alcohol addiction. U and single individuals show more frequently Brain-Derived Neurotrophic Factor (BDNF), a protein important to
previous suicide attempts. Subjects with personality disorders are nervous system function, have been implicated in suicidal behavior
more frequently U, whereas those affected by affective disorders E. but results are inconsistent.
Conclusions.– In our sample the marital status affects but does not Aim.– To investigate the association between serum levels of BDNF
neutralize the impact occupational status on suicide attempts. The and BDNF genotyping (for val66met) with suicidal behavior.
presence of alcohol addiction confirmed its role as precipitating
factor.
Methods.– Participants were recruited from tertiary care clinical Background and aims.– Suicide is a multidimensional phenomenon
set up of India after approval from Institutional Ethics Commit- whose determinism remains unclear. An immune hypothesis has
tee. Cases (individuals who had attempted suicide) (n = 56) were been advanced postulating an association between suicidal behav-
matched on sex and age to controls (n = 56) with no history of ior and disturbance of the immune system with its interactions with
suicide attempts. cytokines. The aim of this study was to assess serum level of pro
Blood samples were collected with demographic information and inflammatory cytokines: Interleukin-1(Il-1␤), Interleukin-6 (IL-6),
detailed descriptions of suicide attempts. Linear regression anal- Tumor Necrosis Factor (TNF-␣), Interferon-␥ (INF-␥) and anti-
ysis followed by multivariate analysis was used to determine the inflammatory cytokine: Interleukin-4 (Il-4), in suicidal patients
association between BDNF level (dependent variable) and suicidal and to determine associations between cytokine levels and psy-
behavior (key exposure variable), adjusting for age, sex and other chopathological features.
confounding variables. Methods.– We have conducted a case-control study. Suicide
Results.– 112 participants were included in this analysis. In the lin- attempters who have been received in emergency department and
ear regression model, suicidal behavior was significantly associated intensive care unit of Farhat Hached Hospital of Sousse, Tunisia,
with serum BDNF level (OR = 0.38, 95%CI = 0.23–0.63, p < 0.001), but free from chronic inflammatory or autoimmune disorders were
no association observed with val66met polymorphism. recruited. They were compared to control subjects, matched for age,
Conclusions.– Serum BDNF levels can be used as a predictor to sui- sex and body mass index, enrolled among volunteer blood donors.
cidal behavior. However, the findings need to be replicated with Patients were assessed for depression (Beck depression Inventory),
larger cohort study. anxiety (Hamilton Anxiety Scale), hopelessness (Beck Hopeless-
Disclosure of interest.– The authors have not supplied a conflict of ness Scale) and impulsiveness (Barratt Impulsiveness Scale). Serum
interest statement. cytokine levels were measured with ELISA techniques.
Results.– Thirty-one suicide attempters have been recruited.
Patients exhibited significantly lower IL-1␤ (5.88(0.00; 18.91)
E-PP1294 vs 61.23(24.14; 241.93); p < 10−3 ), IL-6 (3.46(3.02; 4.39) vs
Decreased IL-1 serum levels in 30.86 (15.15; 50.99); p < 10−3 ) and TNF␣ (16.11 ± 3.37 pg/ml vs
drug-free suicide attempters 53.38 ± 15.02 pg/ml; p < 10−3 ) serum levels than controls. TNF-
A. Souilem1* , A. Mtiraoui1 , M. Gharmoul1 , J. Sehli1 , M. Achour2 , R. ␣ Serum levels were positively correlated with impulsiveness in
Dahmane1 , S. Saguem2 , S. Ben Nasr1 , B. Ben Hadj Ali1 suicidal patients (r = 0.425; p = 0.019). No association was found
1 Farhat Hached Hospial, Psychiatry Department, Sousse, Tunisia; 2 between cytokine serum levels and severity of depression, anxiety
Faculty of Medecine Ibn Al Jazzar, University of Sousse, Laboratory of and hopelessness.
Metabolic Biophysics and Applied Pharmacology, Sousse, Tunisia Conclusions.– Pro-inflammatory cytokines seem to be valuable
* Corresponding author. markers of suicidal behavior regardless ofthe severity of depres-
sion. Further prospective studies on larger samples are needed to
Background and aims.– Potential involvement of immune mech- support these results.
anisms in the etiopathogenesis of suicidal behaviour has been Disclosure of interest.– The authors have not supplied a conflict of
postulated. Hypotheses regarding an immune-cytokine basis have interest statement.
been advanced with controversial findings regarding predomi-
nance of type-1 or type-2 cytokines.
The aim of this study was to assess serum levels of IL-1, IL-4, and E-PP1296
IFN-␥ in drug-free suicide attempters and to determine potential Using resting state intrinsic network
associations between cytokine levels and clinical parameters and connectivity to identify suicide risk in
psychopathology.
mood disorders
Methods.– IL-1, IL-4 and IFN-␥ serum levels were measured with
J. Stange1* , L. Jenkins1 , S. Pocius1 , K. Kreutzer1 , K. Bessette1 , S.
ELISA techniques in 31 drug-free suicide attempters and 31 healthy
DelDonno1 , L. Kling1 , R. Bhaumik1 , J. Keilp2 , K.L. Phan1 , S.
controls matched for age, sex and body mass index. Current
Langenecker1
symptoms were assessed with Beck Depression inventory, Beck 1 University of Illinois at Chicago, Psychiatry, Chicago, USA; 2
Hopelessness scale, Hamilton Anxiety Rating Scale and barratt
Columbia University, Psychiatry, New York, USA
impulsivity scale * Corresponding author.
Results.– Suicide attempters exhibited significantly lower IL-1
serum levels than controls (p < 0.006). There was no significant dif- Background and aims.– Little is known about the neural substrates
ference between patients and controls regarding IFN-␥ and IL-4 of suicide risk in mood disorders. Improving the identification of
levels. biomarkers of suicide risk, as indicated by a history of suicide-
Conclusions.– Level of IL-1 was significantly decreased in blood of related behavior (SB), could lead to more targeted treatments to
patients with suicidality and these cytokines may help distinguish reduce risk.
suicidal from non-suicidal patients. To use intrinsic network connectivity to identify individuals at risk
Disclosure of interest.– The authors have not supplied a conflict of for suicide, as indicated by a history of suicide-related behavior
interest statement. (SB).
Methods.– Participants were 112 young adults with a mood disor-
der with no history of suicidal behavior (MD), 18 individuals with
E-PP1295 a mood disorder with a history of SB (as indicated by endorsing
Decreased pro-inflammatory cytokine a past suicide attempt), and 82 healthy comparison participants
serum levels in suicide attempters (HC). Resting-state functional connectivity within intrinsic neural
A. Souilem1* , Z. Bouzaabia1 , A. Mtiraoui1 , M. Achour2 , M. Dhoubi1 , networks, including cognitive control network (CCN), salience and
J. Sehli1 , M. Gharmoul1 , R. Dahmane1 , S. Saguem2 , S. Ben Nasr1 emotion network (SEN), and default mode network (DMN), was
1 Farhat Hached hospial, Psychiatry Department, Sousse, Tunisia; 2 compared between groups.
Faculty of Medicine Ibn Al Jazzar, Laboratory of Metabolic Biophysics Results.– Several fronto-parietal regions (k > 57, p < .005) were iden-
and Applied Pharmacology, Sousse, Tunisia tified in which individuals with SB demonstrated distinct patterns
* Corresponding author. of connectivity within (in the CCN) and across networks (DMN-CCN
and DMN-SEN). Connectivity with some of these same regions also
distinguished the SB group from the MD and HC groups when par-
ticipants were re-scanned after 1–4 months. Extracted data defined the most effective intervention of the universal prevention strate-
group membership with good accuracy, sensitivity, and specificity. gies. Therefore, we aim to adequately identify “suicide hotspots”
Conclusions.– These results suggest that individuals with a history in BA, in order to plan interventions that can be implemented to
of SB in the context of mood disorders may show reliably distinct reduce the risk of suicide at these locations.
patterns of intrinsic network connectivity, even when compared Methods.– We contacted local police authorities, the Administra-
to those with mood disorders without SB. Resting-state fMRI is tion of the Hydrographic Region of Alentejo, the Intermunicipal
a promising tool for identifying subtypes of patients with mood Community of BA and local government authorities. We also col-
disorders who are at risk for suicidal behavior. lected information from local news and from health professionals
Disclosure of interest.– The authors have not supplied a conflict of of the Psychiatry Service of the Local Health Unit of Baixo Alentejo.
interest statement. Results.– We identified several “suicide hotspots”, including woods,
bridges, dams and an abandoned building complex. We also tried to
identify all the existing wells of BA and to understand their safety
E-PP1297 conditions, but we found the records concerning these structures
Non-suicidal self-injury and suicidal to be very inaccurate.
behaviour in female adolescents with Conclusions.– There are several “suicide hotspots” in BA, where
effective intervention is possible. Nonetheless, the quality of most
conduct disorder
records is poor, and better official records regarding “suicide
M. Szewczuk-Bogusławska1* , M. Kaczmarek-Fojtar2 , A. Adamska1 ,
hotspots” are needed, as well as better communication among the
F. Dorota1 , B. Misiak1
1 Wroclaw Medical University, Psychiatry, Wrocław, Poland; 2 involved authorities and entities.
Wroclaw Medical University, Department of Emergency Medicine,
interest statement.
Wrocław, Poland
Background and aims.– Background: Non-suicidal self-injury (NSSI) E-PP1299

occurs in adolescence with prevalence rates estimated at 17–18% A cohort study of death by suicide in
and 4–12.1% of adolescents present suicidal behaviour (SB) in parents who bear extremely low birth
community samples. Non-suicidal self-injuries as well as suicidal weight infants
attempts are classified as separate psychiatric diagnoses and are L. Ya-Ling1 , L. Chung-Yi2 , H. Wen-Hsuan3*
referred to as non-suicidal self-injury disorder (NSSID) and suici- 1 National Taiwan University, Department of Nursing, National
dal behaviour disorder (SBD) in DSM-5. The aim of the study was Taiwan University, Taipei, Taiwan, Taipei, Taiwan, Taiwan R.O.C.; 2
to assess the frequency of NSSI, NSSID and SBD in adolescent girls National Cheng Kung University, Department of Public Health,
diagnosed with conduct disorder (CD). College of Medicine, National Cheng Kung University, Tainan, Taiwan,
Methods.– The sample of 208 girls (mean age 15.6 ± 1.1 years) diag- Tainan, Taiwan, Taiwan R.O.C.; 3 Taipei Medical University, School of
nosed with CD were included into the study. To establish a diagnosis Gerontology Health Management and Master Program in Long-Term
of CD all participants were examined by trained psychologist or Care, College of Nursing, Taipei Medical University, Taipei, Taiwan,
child and adolescent psychiatrist. In addition, the CD Section of Pol- Taipei, Taiwan, Taiwan R.O.C.
ish version of MINI-KID was administered to confirm a diagnosis * Corresponding author.
and assess the severity of symptoms. A semi-structured interview
was administered by clinicians to obtain the data about frequency, Background and aims.– Parenting low birth weight (LBW) infants is
recency, methods and functions of NSSI to confirm NSSID criteria a great burden for both parents physically, emotionally, and eco-
according to DMS nomically. Given the great challenge of care and potential loss to
Results.– 52.4% of our sample admitted engaging in NSSI during the the LBW babies, the long-term psychological adaptation among
past year and 52.9% during the lifetime while 39.5% and 23.3% ful- these parents is critically important yet received less attention in
filled DSM-5 criteria of NSSID and SBD, respectively. The prevalence research.
of SBD in adolescent with NSSID was 50.0%. In turn, the prevalence To examine risks of parental death by suicide in association with
of NSSID in the group of SBD(+) individuals was estimated at 52.2%. bearing extremely low birth weight (ELBW, < 1,000 g) offspring and
Conclusions.– High prevalence of NSSID and SBD as well as high death of ELBW infants.
comorbidity of these diagnoses can be expected in adolescent girls Methods.– This was a cohort study where parents of 17,454 ELBW
with CD. infants and 1,913,126 control parents with normal birth weight
Disclosure of interest.– The authors have not supplied a conflict of (≥2500 g, NBW) offspring were identified from Taiwan’s Birth Reg-
interest statement. istry between 1994 and 2013. All study parents were linked to
Taiwan’s Death Registry (1994–2015) for possible suicidal deaths.
Cox proportional hazard model was used to estimate adjusted haz-
E-PP1298 ard ratios (aHRs) of parent’s suicidal death, adjusting for parent’s
Suicide hotspots in Baixo Alentejo: age, marital status, employment status, educational attainment and
identify to intervene urbanization of residential areas.
M.T. Valadas* , S. Farinha-Silva, P. Barbosa, A. Matos-Pires Results.– Forty-seven mothers (2.69‰) and 43 fathers (2.46‰) with
Unidade Local de Saúde do Baixo Alentejo, Serviço de Psiquiatria, ELBW offspring died by suicide. The corresponding figures for
Beja, Portugal parents with NBW offspring were 1.32‰ and 2.21‰. Parenting
* Corresponding author. ELBW offspring was found to significantly increase risk of suici-
dal death in mothers (aHR = 1.80, 95%CI = 1.38–2.40), but not in
Background and aims.– A “suicide hotspot” is a specific, accessible fathers (HR = 1.06 (0.78–1.43)). An increased risk of death by suicide
and usually public site which is frequently used as a location for sui- was also observed in mothers (HR = 1.82 (1.38–2.40)) and fathers
cide and gains a reputation as such. In the region of Baixo Alentejo (HR = 1.48 (1.17–1.86)) who lost their ELBW offspring.
(BA), in Portugal, there are several “suicide hotspots”. This is partic- Conclusions.– Parenting ELBW offspring is associate with higher risk
ularly concerning because the region of BA has one of the country’s of suicidal death in mothers; and death of ELBW offspring may
highest suicide rates. Regarding suicide prevention strategies, there increase risk of death by suicide in both mothers and fathers.
is data supporting various methods and there is a great level of evi- Disclosure of interest.– The authors have not supplied a conflict of
dence suggesting that means restriction for suicide prevention is interest statement.
E-PP1300 Results.– Of 200 psychiatric trainees surveyed across Italy, the

Exploration of the living experience of majority has ‘ever’ considered living abroad. Still, just a quarter took
parents whose offspring committed ‘practical steps’ towards migration, with male trainees considering
migration more than female. Few trainees had ever had a long-
suicide term migratory experience or a short-term mobility experience.
R. Zavrou1* , A. Koutrouba1 , E. Papastavrou1 , A. Charalambous1 , M.
Academic was an important reason for trainees to leave and per-
Karanikola1
1 Cyprus University of Technology, Department of Nursing, Limassol,
sonal a key reason for trainees to stay. Across Italy we found wide
differences concerning their 5 year plan: the majority of trainees
Cyprus
in the south believe they will be working abroad, whereas most of
trainees in the north and central part of the country think they will
Background and aims.– Data show that individuals’ death due to be working in Italy.
suicide affects all family members. Exploration of the living experi- Conclusions.– Many Italian psychiatric trainees have considered
ence of Greek-Cypriot parents whose offspring completed suicide, moving to another country, especially for academic reasons. These
with focus on (a) their meaning-making and interpretations (b) the findings call to improve opportunities, particularly in the south
effects of suicide on them and (c) their needs. part of the country, and help to better understand the social and
Methods.– A phenomenological methodology based on van demographic variations across Europe that may play a role in these
Manen’s approach was employed. According to purposive and migratory flows.
snowball sampling five mothers and one father participated, Disclosure of interest.– The authors have not supplied a conflict of
following informed consent. Data collection was conducted interest statement.
via semi-structured interviews with open-ended questions
(10/2017–07/2018).
E-PP1302
Results.– The participants clearly described suicide as a sudden,
unexpected, disastrous and traumatic event for the whole fam- Findings of the react (research in early
ily. It appeared that the suicide-related meaning-making was a career psychiatrists and trainees)
dynamic, incessant process. When this was followed by a world- study
view transformation it seemed to partially result to the acceptance S. Naughton1 , M. Asztalos2,3* , M. Pinto da Costa4,5 , N. Jovanovic5 ,
of the suicide event, forming an adaptive coping strategy. Over- O. Kazakova6 , F. Riese7 , O. Andlauer8 , M. Pantovic9 , A.R.
all, this process seemed to endure personal-growth, empowerment Szczegielniak10 , E.F.P.T. Research Working Group11 , K.
and self-motivation process in family members. Furthermore, the Koelkebeck12
participants’ core need involved a constant effort to be enacted in 1 Trinity College, Department of Psychiatry, Dublin, Ireland; 2 Aalborg
terms of protection. For some participants this effort concerned the University Hospital, Department of Psychiatry, Aalborg, Denmark; 3
protection of the memory of their child against the social stigma of Semmelweis University, School of PHD Studies, Budapest, Hungary; 4
suicide. Others expressed their need to protect their dignity against Hospital de Magalhaes Lemos, Hospital de Magalhaes Lemos, Porto,
the public stereotype of them as being ineffective parents. The need Portugal; 5 Queen Mary University of London, Bart’s and London
to protect other family members, and mainly children from the School of Medicine and Dentistry, London, United Kingdom; 6
consequences of distress following suicide was also described. Psychiatric Clinic of Minsk City, Psychiatric Clinic of Minsk City,
Conclusions.– Further qualitative studies in the fathers of those died Minsk, Belarus; 7 University Hospital Zurich, Department of
by suicide are needed. Interventions aiming to reduce the social Psychiatry, Zurich, Switzerland; 8 East London NHS Foundation Trust,
stigma of those completing suicide are also proposed. East London NHS Foundation Trust, London, United Kingdom; 9
Disclosure of interest.– The authors have not supplied a conflict of Clinical Center of Serbia, Clinic for Psychiatry, Belgrade, Serbia;
interest statement. 10 Medical University of Silesia, Department of Psychiatric
Rehabilitation, Katowice, Poland; 11 European Federation of

Psychiatric Trainees, Research Working Group, Bruxelles, Belgium;
12 University of Muenster, Department of Psychiatry and
E-Poster Presentation: Training in Psychiatry Psychotherapy, Muenster, Germany
E-PP1301 Background and aims.–

Migration of psychiatric trainees in Introduction.– The Early Career Psychiatrist Committee of the Euro-
pean Psychiatric Association (EPA-ECPC) and the Research Working
Italy Group of the European Federation of Psychiatric Trainees (EFPT-
F. Altamore1* , C. Palumbo2 , M. Pinto da Costa3
1 RWG) both investigate issues of concern for trainees and early
University of Modena and Reggio Emilia, Department of Biomedical,
career psychiatrists (ECPs) across Europe. EPA and EFPT have collab-
Metabolic and Neuronal Sciences, Section of Psychiatry, Modena,
orated to create the REACT (Research in Early Career Psychiatrists
Italy; 2 ASST Papa Giovanni XXIII, Department of Mental Health,
and Trainees) study.
Bergamo, Italy; 3 Queen Mary University of London, Unit for Social
Objectives.– To investigate the motivations and attitudes of trainees
and Community Psychiatry WHO Collaborating Centre for Mental
and ECPs undertaking research across Europe, along with identify-
Health Services Development, London, United Kingdom
* Corresponding author. ing barriers or difficulties that are faced.
Methods.– A semi-structured 22-item questionnaire was created.
Background and aims.– In Europe high number of psychiatric The question domains investigated nature of research activity,
trainees have ever considered moving to another country, espe- research goals, access to supervisors and funding, along with barri-
cially for salary differences. Although in Italy workforce migration ers faced. A 10-item demographic questionnaire accompanied this.
is widespread in different fields, little is known about migration of The questionnaire was disseminated to psychiatric trainees and
health professionals at an early career stage. ECPs across Europe. This was facilitated through the local commit-
This study aims to identify experiences and attitudes towards inter- tees of EPA and EFPT. In total there were 305 participants, across a
national migration among Italian psychiatry trainees. range of European countries.
Methods.– An online survey was conducted among psychiatry Results.– Results indicated that most participants were highly inter-
trainees from Italy as part of the EFPT Brain Drain Research study. ested in research, but faced major issues engaging in research
activities, e.g. time and funding. They were however highly satisfied
with mentoring and publishing papers. Only half of the partici- Institute of Psychiatry, Psychology and Neuroscience, London, United
pants have already published a paper. A detailed analysis will be Kingdom
presented. * Corresponding author.
Conclusions.–
Discussion.– Our results reinforce previous findings that major Background and aims.– In the UK and internationally, services are
issues influencing engagement in research are time and funding. under increasing pressure to support people presenting with acute
Young colleagues are motivated to perform research, but need to mental health crises, from psychotic episodes to suicidality. People
be provided with encouragement and opportunities. experiencing mental health crises rarely present to mental health
Disclosure of interest.– The authors have not supplied a conflict of services during working hours, and are often supported by ambu-
interest statement. lance staff, police, or emergency department professionals. This
study aimed to deliver a programme of experiential training to
emergency services, emergency department, and acute psychiatric
E-PP1303 staff and assess the impact of the programme.
Anti-stigma interventions to reduce Methods.– The training consisted of mental health simulation train-
ing, involving scenarios with simulated patients played by trained
negative attitudes towards mental actors, followed by group debriefs supported by experienced facil-
illness among medical students itators. Participants took part in one full-day training course.
B. Atienza-Carbonell1* , H. Hernàndez-Èvole1 , V. Validated measures of human factors skills for healthcare, attitudes
Balanzà-Martínez2 towards mental illness, and staff confidence, and surveys with open
1 University of Valencia Medical School, Department of Medicine,
questions, were administered to participants before and after train-
Valencia, Spain; 2 University of Valencia Medical School, CIBERSAM, ing.
Department of Medicine, Valencia, Spain Results.– Statistical analyses found significant improvements in
human factors skills, attitudes towards mental illness, and confi-
dence. Thematic analysis of qualitative data identified emergent
Background and aims.– Medical students are five times more vulner-
themes of interprofessional team working, empathy and under-
able to depression than the general population. A positive attitude
standing, confidence in providing care, and reflective practice that
towards mental illness seems important and desirable in future
participants reported to be improved following training.
clinicians as it may impact on their professional attitudes and the
Conclusions.– This study demonstrates the effectiveness of men-
provision of healthcare.
tal health simulation training in improving the skills, confidence,
A pre-post cohort online survey was conducted to evaluate the effi-
and attitudes of psychiatry, nursing, emergency department and
cacy of an intervention to reduce attitudes and degree of stigma
emergency services staff in supporting patients in mental health
towards mental illness among pre-graduate students.
crises. Benefits were related back to the engaging and experiential
Methods.– All second-year students were invited to complete the
modality of simulation training. The authors hope to further anal-
CAMI, RIBS and MAKS questionnaires before and after taking
yse differences between professions accessing the training, and the
the Psychological Medicine module. A subgroup was invited to
long term impact on their clinical practice.
attend a workshop led by three patients suffering from mental
illnesses. Study participation was voluntary and responses were
interest statement.
anonymized.
Results.– Out of 296 students, 254 and 154 completed the survey
before and after the module (response rates = 85.8% and 52.02%, E-PP1305
respectively). From the study sample (n = 154 respondents), 24 stu-
dents attended the workshop. Significant differences were found Non-pharmacological management of
between workshop attenders and those who only took the module child and adolescent patients at risk
(n = 130). After the intervention, attenders significantly improved for agitation
in the social restrictiveness, benevolence and authoritarianism sub- R. Babalola1* , L. View2 , C. Samsel2 , M. Gipson3
scales of the CAMI questionnaire. However, students taking the 1 Rutgers, Psychiatry, New Brunswick, USA; 2 Harvard, Psychiatry,
module significantly improved only in the authoritarianism and Boston, USA; 3 Stanford, Psychiatry, Stanford, USA
CMHI subscales. * Corresponding author.
Conclusions.– These results suggest that formal and goal-directed

activities including meeting someone with a mental illness may Background and aims.– Most psychiatry trainees have little to no
help reduce the stigmatizing attitudes towards them. Implementa- knowledge about non-pharmacological interventions for agitation
tion of anti-stigma workshops in medical curricula may improve in pediatric patients. hypothesized that children with comorbid
the attitudes of future healthcare professionals. Further studies medical and psychiatric illnesses will have a greater likelihood for
should be performed to demonstrate if follow-up interventions the need of emergency interventions.
could result to be more effective. Aims.– (1) Conduct a needs assessment of residents and
Disclosure of interest.– The authors have not supplied a conflict of fellows in Psychiatry in the Harvard hospitals systems of
interest statement. non-pharmacological interventions for agitation. (2) Conduct a
literature review and explore existing resources/recommendations
regarding agitation with verbal de-escalation. (3) Provide
E-PP1304 recommendations for a training curriculum targeting non-
Supporting patients in mental health pharmacological interventions for agitation for residents and
fellows.
crises through experiential learning Methods.– Behavior Response Team (BRT) data is a cross sectional
for psychiatry, nursing, emergency study which includes information about patients ages 2–20 who
department and emergency services were receiving care at Boston Children Hospital who are at risk for
staff agitation. Descriptive statistics were used to describe some demo-
C. Attoe1* , P. Memon2 , S. Cross1 graphic data. Pearson Chi-square was used to analyze associations
1 South London & Maudsley NHS Foundation Trust, Maudsley among demographic characteristics, diagnosis, and if emergency
Simulation, London, United Kingdom; 2 King’s College London, interventions were used.
The data collected from Harvard residency and fellowship training E-PP1307
programs over a 2 week period. An online questionnaire was dis- Training the trainers: supporting
tributed to 225 all psychiatry trainees including fellows within the
implementation of a modern
Harvard Psychiatry Medical training program.
Results.– The emergency intervention was most significant with
neuroscience curriculum for
the in-patient cohort. The trainee questionnaires revealed that psychiatric training in the UK — the
they were ‘somewhat confiden[t]/prepare[d] to handle agitated royal college of psychiatrists
patients.’ This is consistent with the assumption that a minimal Gatsby/Wellcome neuroscience
number of trainees, especially fellows in child and adolescent psy- project
chiatry, have had verbal de-escalation training.
G. Cuttle1* , W. Burn1
Conclusions.– Pro-active behavior plans assisted in reducing the 1 Royal College of Psychiatrists, Professional Standards, London,
likelihood of an emergency intervention. Trainees at all level
United Kingdom
require verbal-de-escalation training to reduce morbidity and mor- * Corresponding author.
tality.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– The Royal College of Psychiatrists (RCPsych)
interest statement. is running a 5-year programme to transform psychiatric training
in the UK by integrating modern neuroscience. In the first phase
(2016-2018), we reviewed, updated and extended the neuroscience
E-PP1306 content of training. Now, our focus is on embedding these improve-
Use of social media to build mental ments and supporting teaching around the country.
health literacy among medical Methods.– We wanted to identify the support and training needs of
students and primary care physicians psychiatric educators teaching neuroscience. Most are not experts
A. Chachar1* , S. Younus Younus2 , A. Mian Mian2 in neuroscience, but they need to be knowledgeable enough to
1 Aga Khan University, Department of Psychiatry, Karachi, Pakistan; 2 teach the subject and must be skilled and confident enough to teach
Aga Khan University, psychiatry, Karachi, Pakistan it effectively.
* Corresponding author. To address these needs, we developed a series of regional train-
ing events called ‘Brain Camps’: Inspiring Excellence in Neuroscience.
Background and aims.– There are 400 qualified psychiatrists mak- These are one-day immersions in clinically-relevant neuroscience,
ing it an alarming ratio of one psychiatrist to half a million people. consisting of two interwoven strands:
Data shows 20–50 million patients in need for mental health care, Refresher sessions on selected topics from cutting-edge neu-
making a case for capacity building of family practitioners in mild roscience, presented by research-active, expert teachers from
to moderate psychiatric disorders. Due to lack of basic knowledge, universities/research institutions
psychiatric care delivered to patients by general practitioners is Workshops on teaching strategies, facilitated by neuroscientists
suboptimal at best. To address this gap we designed a 36-hour and educationalists.
course in principles of mental health aimed at general physicians. Results.– Brain Camps are open to everyone involved in teach-
Methods.– Literature review supported an effective use of ing neuroscience in psychiatry. Impact is evaluated through pre-
Twitter for student-student and student faculty interactions and post-event surveys. The data show a very positive response to
and engagement. The aim was to actively engage and build training, with participants reporting feeling more ‘up-to-date on
student-teacher relation, to respond to as many individual com- neuroscience’ and more confident in their ability to teach neuro-
ments/communications as possible, to encourage in-participant science effectively.
discussion, and to ensure instant communication and content shar- Conclusions.– An effective programme of training is being devel-
ing. A course hashtag, #PCC was assigned. During the introductory oped to proactively support excellent neuroscience teaching
session, a brief Twitter training was provided. to trainee psychiatrists in the UK. Through the exchange of
Results.– Use of twitter was successful in creating active engage- knowledge, skills and best practice, Brain Camps build teachers’
ment both during and in between classes. Around 60% of the confidence and ensure that trainees receive a high-quality educa-
participants filled out evaluation forms on the platform. The first tional experience in neuroscience.
four weeks were the most active for all aspects of the curricu- Disclosure of interest.– The authors have not supplied a conflict of
lum; interest dwindled in the last few weeks when twitter use was interest statement.
limited more for mandatory functions.
Conclusions.– Overall our experience shows that a twitter platform
was helpful in creating engagement of participants in a 2 month E-PP1308
weekly course of a large >500 student setting. Further research is Improving health outcomes by
needed to ascertain if a combination of engagement methodologies engaging families in patient care: a
would be more successful in sustaining interest over a long course.
medical student curriculum
E. Ekhause* , A. Ford, M. Abrams
interest statement.
Montefiore Medical Center, Psychiatry, Bronx, USA
Background and aims.– Limited access to information about the

lives of patients can be a challenge for physicians managing med-
ical treatments and interventions. The individual patient is part of
an extensive system of influences, including culture, family, and
economics, that affect diagnosis and outcome. The family has a
significant impact on the patient’s prognosis and influences the
physician-patient relationship. Engaging families in management
has been shown to help improve A1c and weight. Research has also
shown, engaging families of a critically ill patient can influence
mortality and length-of-stay. In time-limited clinical encounters,
however, involving families can be challenging and potentially E-PP1310

under-utilized. Due to limited medical student training on engaging Specialty choice and affective
with families and limited understanding on the profound impact
temperament in medical students
families often have on a patient’s health, there is a lack of com-
L. Jouini1* , U. Ouali1 , E. Akrimi Jouini2 , S. Ouanes3 , Y. Zgueb1 , F.
petency, comfort, and efficiency in engaging families in health
Nacef1
education and treatment planning. 1 Razi Hospital, Psychiatry Department “A”, Tunis, Tunisia; 2 Faculty
Methods.– This poster introduces a curriculum designed by psychia-
of Medecine of Tunis-University of Tunis El Manar, Faculty of
try residents trained in family interventions, for medical students to
Medecine of Tunis, Tunis, Tunisia; 3 Hamad Medical Corporation,
include families in brief clinical interviews. Experiential exercises
Department of Psychiatry Rumailah Hospital, Doha, Qatar
expose students to common challenges they encounter. Explo- * Corresponding author.
ration of obstacles to integrating this evidence-based intervention
into real-world practice will be discussed. Background and aims.– Choosing a specialty is a complex process
Results.– The curriculum is being piloted with two groups of that depends on many external and internal factors. Factors that
third year medical students during their psychiatry clerkship. Pre may influence specialty choice among medical students in Tunisia
and post surveys about knowledge, perceived skill, and attitudes have not been evaluated yet. The objectives of this study were to
toward families will be presented. explore the specialty choices of medical students and to determine
Conclusions.– It is our hope that inspiring students to improve com- the factors associated with this choice.
munication with families will lead to improved health outcomes Methods.– This is a cross-sectional, descriptive and analytical study
and that involvement with families may benefit the physician’s including 3rd to 5th year students at the Faculty of Medicine
clinical work and satisfaction. of Tunis, between April and May 2016. Sociodemographic and
Disclosure of interest.– The authors have not supplied a conflict of school data were collected using a pre-established form. Emotional
interest statement. temperament was assessed by a short version of the TEMPS-A
questionnaire. The emotional state was measured by the DASS-21
self-questionnaire. Logistic regression was performed to determine
E-PP1309 the factors influencing the choice of specialty.
Mapping migration and mobility of Results.– Our sample included 416 students with an average age of
psychiatry trainees in Ireland 22.5 years and a gender ratio of 0.58. Nearly two-thirds of students
E. El-Higaya1* , Z. Azvee2 , M. Pinto da Costa3 considered choosing a medical specialty. Hyperthymic tempera-
1 CAMHS inpatient Unit Merlin Park University Hospital, Galway ment was the most common temperament found in our population
Child and Adolescent Mental Health Service, Galway, Ireland; 2 (44.4%), followed by cyclothymic temperament and irritable tem-
Dublin South Central Mental Health Service, and the Royal College of perament. The two factors influencing the choice of specialty were
Surgeons in Ireland, Dublin, Ireland; 3 Unit for Social and Community (i) gender given that more women than men chose a medical
Psychiatry Queen Mary University of London London UK, Institute of specialty and (ii) cyclothymic temperament that was significantly
Biomedical Sciences Abel Salazar, University of Porto Porto Portugal associated with preference for a medical specialty.
and Hospital de Magalhães Lemos, Porto, Portugal Conclusions.– These results could help counselors or psychologists
* Corresponding author. attached to medical schools in their work with students on the
choice of their future specialty. Our findings could also motivate
Background and aims.– Migration of psychiatrists has significant faculties to put in place procedures to encourage female students
impact on mental health services in both donor and host countries. to choose surgical specialties.
Although Ireland has experienced a considerable inwards and out- Disclosure of interest.– The authors have not supplied a conflict of
wards migration of health professionals, there is paucity of research interest statement.
data on mental health professional mobility in Ireland.
The overall aim of the study was to investigate the patterns and
driving forces of short-term mobility and long-term migration E-PP1311
amongst psychiatry trainees in Ireland. Survey on psychiatry trainees’ views
Methods.– A Survey was distributed to all psychiatry trainees in
on smartphone applications for
Ireland, as part of the European Federation of Psychiatric Trainees
(EFPT) Brain Drain study. medical education
Results.– A total of 104 questionnaires were collected. One quar- F. Papouli1* , B. Owen1 , R. Bryce2
1 Northumberland Tyne and Wear NHS Foundation Trust, Medical
ter of the respondents were immigrants, of which half considered
themselves as having same opportunities as the local trainees. More Education, Newcastle on Tyne, United Kingdom; 2 Northumberland
than half of the psychiatry trainees in Ireland had a short term Tyne and Wear NHS Foundation Trust, Rehabiliation, Newcastle on
mobility experience (3–12 months), and even more had a long-term Tyne, United Kingdom
migratory experience (>1 year). A striking majority of respondents
have considered leaving the country, and half of them took practi- Background and aims.–
cal steps towards migration. Trainees considered that work-related Introduction.– A number of smartphone “health applications” is cur-
and financial conditions should be improved in Ireland. rently widely used for patients with mental health problems. There
Conclusions.– Ireland is a donor and host country for psychiatry is a limited number of applications aimed for the use by psychia-
trainees and relies heavily on migrant doctors to provide mental trists and even less applications for the training of doctors in mental
health care. Many of the trainees currently working in Ireland, both health.
migrants and non-migrants, are eager to migrate elsewhere. The Objectives.– Collecting trainees’ views in order to create a local
findings raise awareness of these migratory flows and highlighting smartphone application which will be used for postgraduate train-
the importance of addressing workplace and training unmet needs ing within Psychiatry.
of psychiatry trainees, among other forces driving their migration. Methods.– We created an online survey (SurveyMonkey) which
Disclosure of interest.– The authors have not supplied a conflict of included ten questions on trainee’s views from such an application.
interest statement. The survey was electronically sent to the trainees of our organisa-
tion and we received 35 replies (about one third).
Results.– All trainees reported that they own a smartphone and 66% Trainees from almost all European countries are highly motivated
have used it for work-related calls/texts/emails. 66% use it often to improve their knowledge.
to browse medical pages or search for medical information. The Disclosure of interest.– The authors have not supplied a conflict of
majority would access the British National Formulary application, interest statement.
NHS choices, Patient.co.uk. 73% have downloaded mental health
or physical health applications, such as the Pocket DR, MindShift.
91% would be interested in using a local psychiatric application. E-PP1313
The majority would be interested in clinical guidelines, and then Saving lives – improving psychiatric
for local policies, induction and events’ timetables, wards’ infor- trainees’ confidence with emergency
mation and trainees’ rota. Not many trainees were interested in
equipment
psychiatric theoretical texts. Only 12% reported having concerns
S. Tai* , C. Wyke
about accessing information from an application and these were
Maudsley Hospital, South London and Maudsley NHS Foundation
related to whether information would be regularly updated.
Trust, General Adult Psychiatry, London, United Kingdom
Conclusions.– The replies suggest that there is interest from the * Corresponding author.
trainees’ side and their suggestions for the content will be taken
into consideration for the building of the application. Background and aims.–
Disclosure of interest.– The authors have not supplied a conflict of Background.– Medical emergencies in psychiatric inpatient set-
interest statement. tings can be life threatening and Psychiatry Core Trainee (CT)
doctors are expected to lead these situations. CT doctors have been
well trained in the theoretical management of emergencies but
E-PP1312 often receive no training in the use of the emergency equipment
Taking care across borders: available on their psychiatric wards, and so still do not feel confi-
preliminary results from a European dent in using this equipment.
survey about psychiatry trainees and Aim.– To improve Psychiatry CT doctors’ confidence in using emer-
gency equipment available on site during medical emergencies.
refugee mental health
Methods.– Following a pilot teaching session at one site, we received
I. Frankova1 , G. Menculini2,3 , L. Pischiutta3,4 , I. Riboldi3,5* , K.
positive feedback and expanded this teaching to all sites at the
Scheeres6 , L. Uzer-Kremers7
1 Bogomolets National Medical University, Department of biannual local induction. We organised a 20 minute peer-led, inter-
active, hands-on teaching session and surveyed the doctors before
Psychosomatic medicine and psychotherapy, Kyiv, Ukraine; 2
and after the session to assess if this was an intervention that met
University of Perugia, Department of Psychiatry, Perugia, Italy; 3
our aim.
Italian Society of Psychiatry, Young Section, SIP Giovani, Italy, Italy; 4
Results.– Prior to the teaching, only 6% of doctors reported being
University of Udine, Department of Psychiatry, Udine, Italy; 5
confident in using the emergency equipment, but this rose to 87%
University of Milano Bicocca, Department of Psychiatry, Monza, Italy;
6 Avon & Wiltshire Mental Health Partnership NHS Trust, Community following the teaching. On average, prior to the teaching, only 12%
of doctors thought they could locate, and 41% felt confident in using
Perinatal Mental Health Team, Bristol, United Kingdom; 7 Jules Verne
key equipment such as anaphylaxis kits and oxygen. This improved
Medical University, Department of general adult psychiatry in CHI
to 97% (locate equipment) and 80% (use equipment) following the
Clermont de l’oise, Amiens, France
* Corresponding author. teaching.
Conclusions.– A larger trial has confirmed our earlier results that
Background and aims.– Many European countries have seen an a short, hands-on, teaching session led by fellow CT doctors can
abrupt increase in terrorist threats over the last few years. Due to significantly improve confidence in locating and using emergency
war and persecution 68,5 million people were uprooted worldwide equipment.
in 2017 (United Nations High Commission for Refugee’s-UNHCR Based on feedback received, we plan to continue to revise and hone
report). Forcibly displaced persons (FDPs) are more at risk for devel- this session to maximise its impact.
oping PTSD, anxiety, depression, psychosis, somatic disorders. The Disclosure of interest.– The authors have not supplied a conflict of
WHO recommends specific training for mental health care profes- interest statement.
sionals.
The aim is to survey European psychiatric trainees about their
knowledge of the FDPs mental health issues. E-PP1314
Methods.– An online questionnaire was designed by the Euro- Non-pharmacological interventions
pean Federation of Psychiatric Trainees-EFPT Psychiatry Across for the treatment of metabolic
Borders-PAB Working Group, distributed via local networks among syndrome risk factors in
European trainees in 2017.
schizophrenia individuals–a
Results.– 408 respondents from 33 European countries answered
the survey (64% female, 36% male, mean age 30). 71% trainees had systematic review
contact with FDPs in the last 12 months; 80% had encountered E. Tumiel* , M. Lew-Starowicz, A. Wichaniak, M. Jarema
refugees as part of clinical work. The majority (75%) expressed a Institute of Psychiatry and Neurology, III Department of Psychiatry-,
strong interest in the issue of FDPs’ mental health, only 34.5% felt Warsaw, Poland
confident assessing and treating them. Specific training was pro-
vided to 16% of trainees, but only 25% felt it was adequate. Trainees Background and aims.– People suffering from schizophrenia are
rated transcultural competencies, PTSD and trauma management notably vulnerable to the risk factors of metabolic syndrome(MS)
training, as the most necessary skills to confidently manage trau- which reduces their quality and length of life. The increased risk
matised refugees. of MS is related with low physical activity, an unhealthy diet and
Conclusions.– This survey shows a clear unmet need for specific the side effects of antipsychotic drugs. Non-pharmacological inter-
training regarding refugee mental health for psychiatry trainees. ventions seem to be important in the prevention and therapy of
Trainees rated PTSD prevention and acute trauma management as MS.
the most necessary skills for managing traumatized patients con- This paper provides an overview of published studies and criti-
fidently. Existing training programmes may need improvement. cal analysis of pilot programmes involving non-pharmacological
measures aimed at prevention and treatment of risk factors for E-PP1316

metabolic syndrome in patients with schizophrenia. Care training for psychiatric nurses in
Methods.– We searched the PubMed, PsycARTICLE, Cochrane
Tunisia, what’s the difference with
Library databases to identify clinical trials. We included full-text
studies that met the following criteria: age > 18 years, the diagnosis
western countries?
of schizophrenia or schizo affective disorder, monitored parame- Z. Boudali1 , Y. Zgueb2* , R. Jomli2 , F. Znaidi1 , F. Nacef2
1 Razi Hospital, Psychiatry B, Manouba, Tunisia; 2 Razi Hospital,
ters associated with metabolic syndrome.
Results.– All 1555 references were evaluated for inclusion in the Psychiatry A, Manouba, Tunisia
review and 20 met the inclusion criteria. The non-pharmacological
interventions led to improvement in physical health and showed Background and aims.– The psychiatric nurse is of paramount
a promising potential for implementation in the treatment pro- importance, he participates in the restoration of the physical and
grammes dedicated to this particular group of patients. However, psychological integrity of the patient.
critical analysis revealed limitations, which implies the direction of The aim of the study was to evaluate the training of psychiatric
future research. nurses in Tunisia and compare it with the training in western coun-
Conclusions.– Patients suffering from schizophrenia can benefit tries.
from non-pharmacological interventions aimed at counteracting Methods.– We present a cross-sectional descriptive study on 30
the risk factors for MS. These should also include a motivation nurses of the psychiatric department “A” at the Razi hospital in
module in order to improve compliance and reduce drop-out. Tunisia, from February to March 2018.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The majority of nurses received theoretical training during
interest statement. their studies (80%). Nurses who received practical training dur-
ing their studies accounted for 56%. Ninety per cent confirmed
that their nursing colleagues were providing their supervision.
E-PP1315
Nurses who received continuous supervision in the service dur-
Successful experience in the ing their work accounted for 43.3% of all nurses surveyed. Nurses
interaction between the nursing who received continuing education accounted for 56.7%. The same
leagues in psychiatry and other health nurses who said they received continuing education in psychiatry,
areas said they received training about the caring relationship as well.
M.C. Vastag Ribeiro De Oliveira1* , F.A. Sevilha da Cunha1 , A.F. De received training in psychiatric interview accounted for 53.3%.
Souza Santos1 , A.C. Gregorio Raposo1 , M.A. Silva Quiroz1 , M.R. Conclusions.– In western countries, the role of the nurse is governed
Carbel1 by the law. In Tunisia, the data concerning the specialized training
1 University of Western São Paulo, Faculty of Nursing, Presidente of nurses as well as their practices of psychiatric maintenance and
Prudente, Brazil their functions in the service are still vague.
interest statement.
Background and aims.– The formation of human resources in health,
specifically in the area of Nursing, underwent transformations
implying changes in the formation of the professional adapted to
reality, prepared to deal with the changes faced by the health sec- E-Poster Presentation: Women, Gender and
tor. It is notorious that there is social pressure for institutions to Mental Health - Part II
seek greater to operationalize these transformations involving the
integration and sharing of interdisciplinary knowledge in health
actions that enable learning and reflection that transcend knowl- E-PP1317
edge become indispensable in the formation of the contemporary Design an assess instrument of sexual
professional. violence and gender discrimination in
Methods.– The operationalization for interdisciplinary integration
between the specialties in nursing started from the discussion
medical residents
D.P. Guizar-sanchez1* , A. Fresán-Orellana2 , I. Vargas-Huicochea3 ,
related in the process of teaching in health. It is questioned so
L. Manjarrez1 , A. Silva-Aragón4 , G. Heinze Martin1
that knowledge and individual be valued the condition as subject, 1 Universidad Nacional Autónoma de México, Posgraduate Unit,
why we insisted on analyzing it in specialties? Ambitious and chal-
Mexico City, Mexico; 2 Instituto Nacional de Psiquiatría,
lenging, we understand the need to meet, discuss integrality and
Investigaciones Epidemiológicas, Mexico City, Mexico; 3 Universidad
broader clinical, focusing on the subject and not thematic area,
Nacional Autónoma de México, Departamento de Psiquiatría y Salud
we put together groups of leagues in different areas, discussions
Mental, Mexico City, Mexico; 4 Universidad Nacional Autónoma de
on common themes and practical activities developed in the aca-
México, SUAyEd, Mexico City, Mexico
demic community through evidence-based reality and roadmaps * Corresponding author.
to be developed in the institutions of the Network of Health Care
we share the themes and prepare in advance. Background and aims.– Although specialist medical training is an
Results.– The result of these meetings provided the reflection of important pillar for a future effective health system, there is evi-
human values in the biopsychosocial and integral field of commu- dence of violence during their trainship. Residents usually did
nity, such as the hierarchy of health care. not spontaneously report violence, but they identify when asked
Conclusions.– The opportunization and integration of interdis- directly, there is a need of an instrument to assess the two less
ciplinary contents in theoretical-practical activities favor the frequently reported types of violence (gender discrimination and
teaching-learning process, enabling the strengthening of new sexual violence)
methodological postures to be used in the daily practice of cur- Aim.– design a screening instrument assessing sexual violence and
riculum for the formation of the health professional in an integral gender discrimination in medical residents.
way. Methods.– The study was conducted at the National Autonomous
Disclosure of interest.– The authors have not supplied a conflict of University of Mexico (UNAM), Mexico City. Participants provided
interest statement. informed written consent. The research and ethics committees
approved the study. The design of the instrument consists in two
phases: (1) Qualitative phase: 3 focus groups were formed, each E-PP1319
with 8 medical residents. A focal group guide with 15 questions Resilience and intimate partner
was prepared according to the literature review. A total of 24 med-
violence among wives of alcohol
ical residents participated, 50% women (n = 12), age of 29.5 years
(SD = 2.43), mostly single (62.5%, n = 15) and without children (75%,
dependent patients
n = 18). They were coursing 12 different medical specialties courses. A. Khivsara1* , K. Srinivasan2 , J. Pradeep2
1 All India Institute of Medical Sciences, Psychiatry, Jodhpur, India; 2
The contents of the interviews were coded and categorized. Subse-
quently, the categories that emerged were organized according to St. John’s Medical College Hospital, Psychiatry, Bangalore, India
a pre-established category tree and analyzed. Finally, the interpre-
tation of the testimonies was triangulated. (2) Quantitative phase, Background and aims.– Resilience has been broadly defined as
the information was incorporated into a 62-item instrument. For capacity to positively adapt to, or regain levels of functioning after
content validity, gender and sexuality experts were asked to rate difficult life experiences. While other studies have focused on the
on a four-point scale. Items with a Content Validity Index(CVI) over consequences of Intimate partner violence(IPV), few have exam-
0.80 were remained. ined factors linked to Resilience among wives with abuse by alcohol
Results.– This study provided a 62 item-instrument for assessing dependence spouses.
sexual violence and gender discrimination in medical residents. To examine association between self-esteem, marital satisfaction
Conclusions.– Future research is needed to test psychometric prop- and social support and measures of Resilience in wives with spousal
erties of the instrument. abuse.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– A cross-sectional study was undertaken with subjects
interest statement. as wives (18–50 years) of patients with alcohol dependence syn-
drome, married for at least 3 years, currently staying with their
husband. Wives were screened for any psychiatric morbidity by
E-PP1318
using Modified M.I.N.I screen and were excluded if found to have
Gender dysphoria in children and any morbidity. Severity of alcohol dependence was assessed in hus-
adolescents bands. Marital quality scale, Index of spousal abuse, Resilience scale
R. Hernández Antón1* , R. González Collantes1 , M. Gómez García1 , for Adults, Rosenberg self-esteem scale and Multidimensional scale
N. De Uribe Viloria1 , P. Datta2 of perceived social support were administered to subjects.
1 Psiquiatría, Psiquiatría, Valladolid, Spain; 2 Universidad Politécnica
Results.– Most of subjects (85.1%) had high resilience. Number of
de Torino, Inf, Torino, Italy family members, occupation, severity of alcohol dependence had a
negative association while education of women, self esteem and
social support were positively correlated with Resilience. About
Background and aims.– Gender dysphoria is incoherence between 55% of women reported IPV. No association was found between
the sex a person feels or expresses and the biological. total resilience with either Non-physical IPV or physical IPV, except
Aims.– Revise the inclusion criteria for hormone therapy in gender some subdomains.
dysphoria. Expose the multidisciplinary approach. Make differen- Conclusions.– There is a big scope for undertaking studies to further
tial diagnosis with other psychological disorders. estimate Resilience among women in coping with violence by alco-
Methods.– Case: Patient woman (biological sex: male) of 11 years, hol dependent spouses. Mental health problems in wives need to
who attends consultations at her own request. she resides with be addressed by physicians and psychiatrists while treating these
her parents in the family home. She is attending the 6th EPO with women both at primary care settings specialized care centres.
good performance. No medical history of interest. Since she was Disclosure of interest.– The authors have not supplied a conflict of
five, she has presented a marked and insistent desire to belong to interest statement.
the opposite sex and dislikes her sexual characteristics since she
was 7 years old; fantasies and dreams about belonging to the other
sex. She has always chosen activities with female stereotypes and E-PP1320
has avoided contact sports and played with cars. She has always Pregnancy and psychotropics: a
preferred feminine companies and liked to disguise herself as a
princess. Insistence of being called by a female name. EPP: She
systematic review
has long hair and ambiguous clothes. Euthymic. No anxiety. No S. Fink, P. Korenis*
alterations of the content or course of thought. No hallucinations. BronxCare Health System, Psychiatry, Bronx, USA
Biological rhythms preserved. No autolytic ideation.
Results.– Diagnosis: Gender dysphoria. Therapeutic intervention: Background and aims.– Pregnancy presents itself as a unique
Support and facilitation of the process of identity construction. Joint challenge to any woman. The complexity compounds when the
monitoring of Psychiatry, psychology and endocrinology. pregnant woman also has a severe and persistent mental illness.
Conclusions.– ¿Is the Gender Disphoria a pathology? The EU recom- Few studies exist that make clear recommendations as to what
mends a reclassification as no pathological disorders in ICD-11. The medications psychiatrist should prescribe pregnant women with
main difficulty is the differential diagnosis; there may be comorbid- bipolar disorder or schizophrenia. Most literature is retrospective
ity with others mental disorders which are not exclusive (psychotic or anecdotal and are not randomized controlled trials. Here we
disorder, OCD, personality disorders and other disorders of gender present a systematic review of studies based on pregnant women
identity). with schizophrenia and bipolar disorder.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Using PubMed, Ovid and Cochrane, we identified studies
interest statement. using the key words bipolar disorder, schizophrenia and pregnancy.
268 studies were reviewed and further screened out to meet our
selection criteria.
Results.– We review the common medications prescribed, most
common side effects noted and the impact on both the patient
and the baby throughout the course of pregnancy and post partum
period. Consistently, recent use of second generation antipsy-
chotics have become first line treatment options for both bipolar
disorder and schizophrenia at minimum necessary doses to contain Objectives.– We aimed to investigate the current prevalence of sex-
symptoms. The rationale for utilizing second generation atypical ual dysfunction (SD), mood and anxiety disorders in female patients
antipsychotics will also be reviewed. with Fibromyalgia (FM).
Conclusions.– We aim to add to the growing literature support- Methods.– The study group consisted of 40 female patients diag-
ing the use of second generation atypical antipsychotics for both nosed with FM according to the American College of Rheumatology
schizophrenia and bipolar disorder in pregnant patients. We also criteria who were followed at the Pain Treatment Center in Tunis.
hope to emphasize the need for comprehensive studies dedicated to The control group consisted of 30 female from the general popula-
understanding this complicated time in the life course of a woman. tion.
Disclosure of interest.– The authors have not supplied a conflict of Mood and anxiety disorders were diagnosed according to the DSM
interest statement. IV.
Fibromyalgia Impact Questionnaire (FIQ), and Female Sexual Func-
tion Index (FSFI) were used.
E-PP1321 Results.– The mean age of the participants (n = 70) was 39.5 ± 6.5
Quality of live in women during years. The majority of women were unemployed (74%). Thirty three
menopause patients (82.5%) with FM were diagnosed with SD. The most com-
K. Siala1 , Y. Mejdoub2 , L. Zouari3 , J. Dammak2 , M. Maalej3 , M. mon SDs in patients with FM were lack of sexual desire (n = 16,
Maalej3* 48.5%) and arousal disorder (n = 10, 30%). Lack of sexual desire
1 Ben Arous University Hospital, Department of Gynecologie, Tunis, (p = 0.01), orgasm disorder (p = 0.03), and arousal disorder (p = 0.04)
Tunisia; 2 Hedi Chaker University Hospital, Department of were observed significantly more frequently in the patient group
Community Medicine, Sfax, Tunisia; 3 Hedi Chaker University than in the control group. Among the patients with FM,41 (52.5%)
Hospital, Department of Psychiatry “C”, Sfax, Tunisia had a mood disorder, and 15 (37.5%) had an anxiety disorder. The
* Corresponding author. most common psychiatric disorders were major depression and
generalized anxiety disorder. Patients with FM and SD showed sig-
Background and aims.– nificantly higher scores of QIF with sleep disturbance and lack of
Introduction.– Menopause is associated with complex changes that well-being.
significantly affect the quality of life (QOL) of postmenopausal Conclusions.– Fibromyalgia has negative effects on female sexual
women. function that are aggravated by depression.
Objectives.– To study the quality of life of postmenopausal women Disclosure of interest.– The authors have not supplied a conflict of
and the factors correlated with impaired QOL. interest statement.
Methods.– We conducted a descriptive cross-sectional study among
menopausal women, aged between 40 and 60, who are consultants
at the Sfax –Tunisia Basic Health Centers. We used the SF36 scale E-PP1323
and the Qualifemme in version 32 to evaluate QOL. What does fibromyalgia hide in
Results.– Seventy-five menopausal women participated; their aver- women?
age age was 55.2 years. In the majority of cases, they did not exceed H. Maatallah* , R. Damak, I. Berrahal, N. Ghazouani, W. Cherif, M.
the secondary school level (74.7%), were housewives (46.6%), lived Cheour
in the city (97.7%), had an average socio-economic level (78.7%). The Razi Hospital, Psy E, Tunis, Tunisia
study of QOL in our sample according to SF36, showed impaired QOL * Corresponding author.
in 80% of cases. According to the Qualifemme, the expressed gene
was in decreasing order of the climatic pole, the psycho-social pole, Background and aims.– Fibromyalgia is a medically unexplained
the urogenital pole and the somatic pole. The overall mean SF36 polyalgic syndrome affecting 1.3 to 2% of the general population.
was correlated with standard of living (p = 0.005), number of chil- This pathology affects women seven times more than men. The
dren (p = 0.04), anxiety (p < 10−3 ), to the perception of menopause etiology remains unknown. Functional origin is strongly suspected
(p = 0.05), to the presence of sexual dysfunction (p = 0.05), notably with importance of psychiatric comorbidities.
to the sexual arousal disorder (p < 10−3 ). The mean score of Qual- Objectives.– To evaluate the prevalence of psychiatric comorbidities
ifemme was correlated with standard of living (p = 0.003), level of in women with fibromyalgia and to study the relationship of this
education (p = 0.011), anxiety (<10−3 ), and depression (p = 0.003), pathology to psychotrauma
frequency of intercourse after menopause (p = 0.016), FSFI sexual Methods.– A longitudinal and evaluative study took place at the Pain
arousal disorder (p = 0.012). Treatment Center in Tunis from January 2nd to April 30th, 2018.
Conclusions.– We discover many complaints in the quality of life Psychiatric disorders of Axis I and Axis II were assessed by DSM IV
of climacteric women. We play an important role helping women Evaluation of traumatic events in childhood by the Childhood
manage menopausal changes. Trauma Questionnaire.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Fifty women were retained, the average age was 35 ± 5
interest statement. years. Two-thirds were married and half of the patients were not
working. Forty patients (80%) had Axis I Disorders. The mood disor-
ders found in our patients were: 60% major depressive episode, 20%
E-PP1322 recurrent depressive disorder and 20% bipolar disorder. Anxiety
Psychosexual impact of fibromyalgia disorders were found in 40% of our patients with 70% anxiety gener-
in women alized disorder, 20% post traumatic stress disorder and 10% specific
H. Maatallah* , R. Damak, N. Ghazouani, W. Cherif, I. Berrahal, M. phobia. Personality disorders were found in 50% of our patients
Cheour with: 30% histrionic, 30% obsessional compulsive (p = 0.01), 20%
Razi Hospital, Psy E, Tunis, Tunisia dependent and 20% depressive.
* Corresponding author. The majority of our patients reported traumatic events during their
childhood (75%). The traumatic events significantly associated with
Background and aims.– Fibromyalgia (FM) is a chronic muscu- FM were: child maltreatment 80% (p = 0.002), sexual abuse 60%
loskeletal pain syndrome characterized by widespread body pain (p = 0.003).
and fatigue. FM has 2% prevalence in the community and occurs at Conclusions.– The importance of psychiatric comorbidities and
a four- to sevenfold greater prevalence in women than in men. psychotrauma in women with FM requires multidisciplinary man-
agement.
Disclosure of interest.– The authors have not supplied a conflict of of depression than men. Converging research in neurobiology and
interest statement. gender studies made us wonder if reconceptualization of depres-
sion as a response to being in a hopeless situation in which one
feels helpless (lacking agency) with subtypes of primarily internal-
E-PP1324 izing and primarily externalizing would eliminate current gender
The effects of prenatal maternal differences.
stress, loneliness/helplessness, Methods.– As part of another study, we have been collecting patient
life stories. The diagnoses in our samples matched the conventional
depressive symptoms, sleep
preponderance of women for depression and men for antisocial or
difficulties and social support on child bipolar diagnoses. We developed a rubric for determining from the
temperament in 3 months postpartum life story if the person was in a self-perceived hopeless situation in
M.J. Soares1 , S. Magano2* , M. Marques1 , S. Bos1 , A.T. Telmeira1 , B. which no opportunity for agency to change could be seen. We then
Maia1 , A.P. Amaral1 , C. Marques1 , J. Azevedo1 , S. Xavier1 , M.J. asked if the person was internalizing (classic symptoms of depres-
Martins1 , A. Macedo1 sion with lack of interest, anhedonia, abulia, and loss of capacity
to act – essentially a collapse inward) or externalizing (engaging in
Psychological Medicine, Coimbra, Portugal; 2 Centro Hospitalar e risky behaviors, fighting, and being more irritable and/or aggres-
Universitário de Coimbra, Department of Psychiatry, Coimbra, sive – essentially, purposeless action). We then reviewed the life
Portugal stories from these perspectives.
Results.– Within our reconceptualization of depression, gender
differences disappeared and the numbers of men and women diag-
Background and aims.– Mother’s wellbeing in pregnancy can neg-
nosed as depressed were equal. Men externalized more, while
atively impact child’s development, including temperament. This
women externalized more.
study aims to explore if maternal stress, social support, loneli-
Conclusions.– Gender differences in incidence and prevalence of
ness/helplessness, sleep difficulties and its interference in daily
depression may be more a result of different socialization of men
functioning, non-restorative sleep, and depressive symptoms in
and women for how to respond to feelings of hopelessness and
pregnancy (T0) are correlates/predictors of mother’s perception of
helplessness than of their intrinsic biology.
the child’s difficult temperament at 3 months postpartum (T1).
Methods.– 392 pregnant women, with no-risk pregnancies, aged
interest statement.
19–44 years, 93.1% married, completed a booklet of questionnaires
in T0 and T1, which included PDSS, Loneliness/Helplessness-POMS
index, QTDC, questions to assess stress, social support, difficul- E-PP1326
ties in initiating (DIS), maintaining (DMS) terminating sleep (DTS),
Psychological distress, negative and
non-restorative sleep (N-RS) and sleep difficulties interference in
daytime functioning, specifically in daily life/work (SDIDF-DL/W) positive affect, stress, marital
and in humour (SDIDF-H). satisfaction and sleep: comparison of
Results.– Mothers perception of child difficult temperament in T1 women with infertility and without
was poorly and positively correlated with PDSS-Total (p < .01), with infertility
DMS (p < .01), N-RS (p < .01), SDIDF in daily life/work (p < .05) and F. Urbano1 , M. Marques2* , L. Lemos3 , S. Simões4 , B. Rodrigues
in humour (p < .01). Mother’s T0 stress, social support, and lone- Maia5
liness/helplessness were not significantly associated with child 1 Miguel Torga Higher Institute, Research and Development
temperament/T1. Hierarchical regression analysis showed that Department, Coimbra, Portugal; 2 Miguel Torga Higher Institute
PDSS-T, DMS, N-RS, SDIDF-DL/W and SDIDF-H in T0 explained 8.0% ISMT, Coimbra, Portugal; 3 Miguel Torga Higher institute ISMT,
of the child’s difficult temperament in T1. The initial significant con- Research and Development Department ISMT, Coimbra, Portugal; 4
tribution of PDSS-T disappeared after sleep variables were entered Miguel Torga Higher Institute, Research and Development
in the model. The only significant predictor was SDIDF-H. Department ISMT, Coimbra, Portugal; 5 The Catholic University of
Conclusions.– Mother’s depressive symptoms, sleep difficulties, and Portugal, Regional Centre, Braga, Portugal
particularly sleep difficulties interference in daytime function- * Corresponding author.
ing/humour in pregnancy may have consequences on mothers’
perception of baby’s difficult temperament at 3 months post- Background and aims.– Background: There are few national and
partum. It is necessary to promote maternal mental health in international studies comparing women with infertility and preg-
pregnancy to prevent negative consequences on child’s develop- nant women (fertile) in terms of anxiety and depressive symptoms,
ment. negative and positive affect, stress, marital satisfaction and sleep.
Disclosure of interest.– The authors have not supplied a conflict of Aims: To compare anxiety, depression, negative and positive affect,
interest statement. stress, marital satisfaction and sleep levels between women with
infertility and women without infertility; to explore associations
between the infertility situation and sociodemographic, clinical and
E-PP1325 health variables.
A reconceptualization of depression Methods.– Two samples (129 women with infertility; age,
eliminates gender differences in its M = 34,99; SD = 4,45; range = 25–45; 58 women without infertility;
age, M = 32,08; SD = 3,87; range = 24–39) responded to a protocol
prevalence in a rural primary care
composed by a questionnaire with sociodemographic, clinical and
clinic in Northern New England, USA health questions, the Profile of Mood States-30 (POMS-30), the
L. Mehl-Madrona1 , B. Mainguy2* Depression, Anxiety and Stress Scales-21 (DASS-21), the Marital
1 University of Maine, Graduate School, Orono, Maine, USA; 2 Life Areas Satisfaction Assessment Scale (EASAVIC) and the Insom-
University of Maine at Orono, School of Social Work, Orono, USA nia Severity Index (ISI).
Results.– Women with infertility presented higher levels of depres-
Background and aims.– Within the criteria of the American Psy- sion and insomnia, as well as lower levels of positive affect, than
chiatric Association or the International Classification of Disease women without infertility. In all dimensions of marital satisfac-
(ICD), women have a 2–4 fold greater incidence and prevalence tion women with infertility had lower scores than women without
infertility. Concerning anxiety and stress, there were no differences University Centre, Psychiatry Department, Coimbra, Portugal; 3
between the two groups. Miguel Torga Higher Institute, Miguel Torga Higher Institute,
Conclusions.– The study confirms that infertility is associated with Coimbra, Portugal
the decrease of women’s psychological well-being, mainly anxi- * Corresponding author.
ety and depressive symptoms, negative and positive affect, stress,

marital satisfaction and sleep. These results are important given Background and aims.– Perinatal anxiety has not been so consid-
the paucity of studies combining infertility and sleep areas, which ered as perinatal depression, but the few rigorous epidemiologic
should be considered in psychological interventions with women studies prove that it is equally prevalent and that depression and
with infertility, along with the other variables. anxiety comorbidity seems to be higher in the perinatal period
Disclosure of interest.– The authors have not supplied a conflict of (Dennis et al., 2017). Knowledge about perinatal anxiety disorders
interest statement. prevalence in Portugal is very scarce.
Objectives.– To estimate the prevalence and comorbidity rates and
predictors of postpartum Major Depression (MjD) and Anxiety Dis-
E-PP1327 orders (AD) according to the DSM-5 diagnostic criteria at the sixth
Minor psychiatric disorders in month postpartum.
Methods.– 349 women (Mean age = 32.25 ± 5.832 years) answered
Brazilian female shift workers
the Perinatal Depression Screening Scale-24 (PDSS-24) and the
J.C. Silva1 , H. Theodoro2 , M.T.A. Olinto1 , A. Ludwig Neutzling1*
1 Profile of Mood States-27 (POMS-27) in the second trimester of
Universidade do Vale do Rio dos Sinos, UNISINOS, Postgraduate
pregnancy and were interviewed with the Diagnostic Interview for
Program in Collective Health, São Leopoldo, Brazil; 2 Universidade de
Psychological Distress-Postpartum at the sixth month postpartum
Caxias do Sul, Nutrition Course, Caxias do Sul, Brazil
* Corresponding author. (Mean age of the baby = 25.54 ± 8.252 weeks).
Results.– The postpartum prevalence of MjD was of 5.7% (n = 20),
Background and aims.– with half of cases presenting the specifier “with anxious distress”;
Introduction.– Minor Psychiatric Disorders (MPD) have been stud- of any Anxiety Disorder was of 3.2% (n = 11), being Generalized Anx-
ied, as one of the possible changes in mental health of shift workers. iety Disorder (GAD) the most prevalent (n = 8; 2.3%), followed by
The same has defined, according to Goldberg & Huxley (1992), as Panic Disorder (n = 2, 0.6%) and Social Anxiety Disorder (n = 1; 0.3%).
disorders related to insomnia, irritability, fatigue, forgetfulness, dif- More than half (n = 6; 5.5%) of women with an AD (all PAG) also
ficulty concentrating and somatic complaints. It have estimated had MjD. Depressive symptomatology and negative affect in preg-
that worldwide prevalence of MPD in the general population is 7% nancy were associated with postpartum MjD and AD (odds ratio
to 30%. [OR] range: 1.12–2.14), experienced individually or together.
Objectives.– To identify the prevalence of MPD in female shift work- Conclusions.– This is the first Portuguese study on postpartum MjD
ers, according to sociodemographic conditions, lifestyle and Sleep and AD prevalence according to DSM-5. Increased recognition of
Quality. their high prevalence and comorbidity will lead to more effective
Methods.– Cross-sectional study, with data collected in the South- screening, prevention and early intervention.
ern of Brazil. Sample composed of 450 female shifts workers. The Disclosure of interest.– The authors have not supplied a conflict of
MPD defined through the Self-Report Questionnaire. The cut-off interest statement.
point used to identify the MPD in the instrument was score > 8
points4 . The data analysis has performed through SPSS (21.0).
Results.– MPD was present in 47.3% of the study. The sample con- E-PP1329
sisted with aged 31 to 40 years (34.7%), white (69.3%), married Influence of anxiety in the compulsive
(54.4%), with 9 to 11 years of schooling (76.8%), non-smokers purchases of women financially
(73.8%), workers of the day shift (76.2%), sleep disturbance (63.3%) educated
and abdominal obesity (49.1%). In the bivariate analysis, early age K.L. Perez Correa1* , A. Guardiola Esmeral2 , E. Parody Camargo2 ,
(p-valor 0.04) and poor sleep quality (p-valor 0.05) were associated L.F. Miranda Terraza3
with MPD. 1 Universidad Cooperativa de Colombia, Facultad de Psicologia, Santa
Conclusions.– Significant association that the lower the age the Marta, Colombia; 2 Universidad Cooperativa de Colombia, Facultad
greater the prevalence of MPD. As in the sleep quality index, sleep de Ciencias Empresariales- contables y de negocios Internacionales,
disorders presented higher prevalence of the MPD. The results are Santa Marta, Colombia; 3 Universidad del Magdalena, Facultad de
in agreement with the current literature, however they are prelim- Ciencias Empresariales, Santa Marta, Colombia
inary results, more analyzes will be carried out to clearly show the * Corresponding author.
conclusions.
Disclosure of interest.– The authors have not supplied a conflict of Background and aims.– The anxious disorder and the need to feel
interest statement. complete generate a disparity in women who have financial edu-
cation, generating economic problems and increased stress.
Determine the influence of anxiety in the compulsive purchases of
women with financial education working in the public sector in the
E-Poster Presentation: Women, Gender and city of Santa Marta.
Mental Health - Part III Methods.– The design of the research is transversal, not exper-
imental and of field, the paradigm is quantitative. The sample
consisted of 300 female employees of the public sector with high
E-PP1328 income and financial education, was applied the checklist IDARE
Prevalence and comorbidity of major Ch. Spielberger, R. Díaz Guerrero and others (1966); To review the
relationship between anxiety, financial education and compulsive
depression and anxiety disorders in
purchases, a Likert-type scale instrument was designed, validated
the postpartum with the Alpha Cronbach coefficient and expert review. Analysis
S. Xavier1 , M.J. Soares1 , J. Azevedo1 , C. Marques1 , S. Meneses1,2 , M. of the ANOVA Covariance, inferential statistics and SPSS was per-
Marques1,2,3 , A. Macedo1,2 , A.T. Pereira1* formed.
Results.– 51% of women meet criteria for the IDARE. The analysis
Psychological Medicine, Coimbra, Portugal; 2 Coimbra Hospital and showed a R2 = 0.682. The result indicates that at higher levels of
stress, the greater the reasons for making purchases, the women E-PP1331
decide to ignore the financial education they have and enter in high Adverse childhood experiences leads
degree of indebtedness, this generating depression for the 57.2%.
to perceived negative attitude of
Conclusions.– The degree of personal acceptance of the self affects
the need to buy, they almost never take into account the finan-
others and the effect of adverse
cial knowledge and put before the needs of satisfaction, they make childhood experiences on depression
unnecessary purchases usually due to problems of couple, family mediated via negative attitude of
and work circumstances. It is recommended a group-type interac- others
tion from public entities for the release of stress and the increase R.K.R. Salokangas
of personal motivation. University of Turku, Department of Psychiatry, Turku, Finland
interest statement. Background and aims.– The attachment theory suggests that adverse
childhood experiences (ACEs) can have an effect on how individuals
perceive other people’s attitude towards them. ACEs have also been
E-PP1330 associated with adult depression.
Emotional and personality We hypothesised that ACEs associate with perceived negative atti-
characteristics of middle-age women tude of others (AoO) and depressive symptoms (DEPS), and that
these associations differ between the genders.
with essential hypertension and their Methods.– Altogether, 692 participants drawn from the general
relation with cognitive efficiency population completed the Trauma and Distress Scale, as a measure-
E. Pervichko1* , E. Borisova2 , M. Darevskaya1 , N. Korsakova1 , S. ment of ACE and its domains: emotional abuse (EmoAb), physical
Kovtoniuk3 , E. Enikolopova1 , A. Vartanov1 , E. Nikonova1 , S. abuse (PhyAb), sexual abuse (SexAb), emotional neglect (EmoNeg)
Kozlovskiy1 , O. Tikhomandritskaya1 , O. Ostroumova4 and physical neglect (PhyNeg); a visual analog scale with the ques-
1 Lomonosov Moscow State University, Faculty of Psychology,
tion: “What kind of attitude do other people take towards you?”,
Moscow, Russia; 2 City Clinical Hospital named after E.O. Mukhin and the self-report scale DEPS on depressive symptoms.
Department of Health of Moscow City, Department of General Results.– In path analyses, ACE total and all its domains associated
Medicine, Moscow, Russia; 3 Center for speech pathology and directly and indirectly, via DEPS, to negative AoO in the whole sam-
neurorehabilitation, Department of speech recovery for children and ple, and in females separately. ACE total, EmoAb, PhyAb, EmoNeg
adolescents, Moscow, Russia; 4 I.M. Sechenov First Moscow State and PhyNeg associated directly and indirectly, via AoO, to DEPS in
Medical University, Department of Clinical Pharmacology, Moscow, the whole sample and in both genders separately. Mediation effect
Russia via AoO was greater than via DEPS. EmoNeg, in all, and EmoAB, in
males, had specific associations both with negative AoO and DEPS.
Conclusions.– ACEs have a direct and indirect, via depression,
Background and aims.– The topic of maintaining of women’s health
negative effect on how adult individuals perceive other people’s
is one of the priorities of modern medicine.
attitude towards themselves. Additionally, negative AoO mediates
This brings to the fore the goal of studying emotional and personal-
the effects of ACEs on depression. Emotional neglect in childhood
ity characteristics of women with essential hypertension (EH) and
associates specifically with negative attitude of others and depres-
their relation with cognitive efficiency of patients.
sion in adulthood.
Methods.– The study involved 43 naive women with uncomplicated
EAH, stage 1–2 (average age is 52.8 ± 6.1) and 43 normotensive
interest statement.
women (average age is 49.1 ± 6.7).
Participants performed the following assessment: Ways of Cop-
ing Questionnaire, Cognitive Emotion Regulation Questionnaire, E-PP1332
Hamilton Depression and Anxiety Rating Scales, Heckhausen’s
Motivational Test, Multi-Motive Grid, Schulte tables test, MoCA Pregnancy termination in a woman
test, CERAD 10-word list, Raven’s progressive matrices test, and with untreated psychosis
Pictogram test. J. Soler Vidal
Results.– EH women differ from their normotensive peers by higher Hospital Benito Menni, Sant Boi de Llobregat, Barcelona, Spain,
rates of anxiety (2.35 ± 1.81 vs 0.26 ± 0.85; p = 0,00) and depres- Hospital Benito Menni, figueres, Spain
sion (1.41 ± 1.88 vs 0.19 ± 0.56; p = 0,00). They are less likely to use
Background and aims.– Perinatal psychiatric disorders are frequent
such coping- and emotion regulation strategies as confrontation
and for this reason, increasingly scientific literature is published
(11.1 ± 4.2 vs 15.4 ± 4.6; p = 0.02), positive reappraisal (13.7 ± 3.2 vs
on this topic. These disorders can involve complications for the life
15.1 ± 3.7; p = 0.03), and planning (11.6 ± 3.4 vs 13.1 ± 3.6; p = 0.02).
of the fetus as well as for the mother herself. However, nowadays,
Women with EH show prevalence of fear of failure over hope for
with a good follow-up and treatment, patients with psychotic disor-
success (-3.40 ± 2.38 vs 8.3 ± 5.6; p = 0,00), lower overall level of
ders can maintain long-term psychopathological stability. Because
achievement motivation (6.16 ± 2.84 vs 13.79 ± 4.8; p = 0,00), and
of this, increasingly more women want to fulfill the desire to be
increased fear of losing control in social situations (9.57 ± 3.29
mothers despite having a psychotic disorder. Thus, preservation of
vs 5.40 ± 2.36; p = 0,00)) and fear of rejection (7.00 ± 3.43 vs
the decision-making capacity during pregnancy is of utmost impor-
4.86 ± 1.43; p = 0,02). The factor analysis (principal components)
tance.
showed the significant relations between described personality
We present a case of a 32-year-old woman admitted to hospital due
characteristics and indicators of cognitive efficiency of EH women.
to psychotic decompensation after been intervened for a pregnancy
Conclusions.– The results justify the need for differentiated
termination in a private gynecologic hospital seven days before.
approach to treatment and psychological support for EH patients.
Methods.– Clinical interviews were done to evaluate her psy-
The research was supported by RFBR; project № 17-06-00954.
chopathological state by two different psychiatrists that have
already been doing research and are experts in using PANSS scale.
interest statement.
Interviews with family members were also done.
Results.– Upon arrival, she presented a PANSS score of 127. She
explains that a week before, a termination of pregnancy was
practiced, an aspect that we later confirm when family members
present a document from a private gynecologic hospital. Family Background and aims.– Mental health problem is a major public
members explain that when termination of pregnancy was prac- health issue globally as well as developing country like Bangladesh.
ticed, she already was with behavioral changes due to the psychotic Among 167 million population about 50% of them are women. In
symptoms When she was discharged, PANSS score was 46. our society most of the female patients don’t come to the hospital
Conclusions.– We think that monitoring patients with a mental or any private chamber of psychiatrists for their treatment. They
health disorder who wish to become pregnant should be very close, mostly depend on treatment practiced by the traditional healers.
so we advocate that the development Perinatal Psychiatry Units is The present study was aimed to assess the pattern of psychiatric
basic. illness among women attending a private psychiatric consultation
Disclosure of interest.– The authors have not supplied a conflict of service in a rural area of Bangladesh.
interest statement. Methods.– This descriptive cross sectional study was done among
the female attending the private psychiatric consultation service in
Tangail from January 2017 to June 2018. All the new patients who
E-PP1333 were attended the psychiatrists were included in the study. Any
Reflections upon interpersonal and duplication was excluded. Socio-demographic data were collected
team dynamics in a diverse mother through a semi-structured questionnaire developed by the authors
and psychiatric diagnoses were made following DSM-V diagnostic
and baby inpatient unit of East
criteria.
London Results.– A total of 1173 female patients were found during the
T. Tsoumpris1* , S. Al Saraf1 , O. Protti2 study period. Most of them (68%) belong to 20-40 years age
1 Senior Trainee in General Adult Psychiatry, City and Hackney group. Among the respondents 62% were lower middle class family.
Mother and Baby Unit, East London NHS Foundation Trust, London, Regarding psychiatric diagnosis major depressive disorders were
United Kingdom; 2 Consultant Perinatal Psychiatrist, City and found 38%, schizophrenia 18%, bipolar mood disorder 15%, obses-
Hackney Mother and Baby Unit, East London NHS Foundation Trust, sive compulsive disorder 12%, conversion disorder 6%, post partum
London, United Kingdom psychosis 4%. Rest of them was other psychiatric disorders.
Conclusions.– Even this significant proportion of female patients
Background and aims.– The City and Hackney Mother and Baby Unit attended the private psychiatric consultation service indicate that
(MBU) is a specialist 12 bedded ward based at Homerton University they need further expansion of psychiatric services in the commu-
Hospital in Hackney, East London. The unit provides assessment nity with special emphasis for their treatment.
and treatment of women who are at risk, or experience signifi- Disclosure of interest.– The authors have not supplied a conflict of
cant mental health difficulties during pregnancy (from 32 weeks) interest statement.
or within the first postnatal year. The unit serves the population of
Hackney Borough – the 6th most diverse London borough- but also
E-PP1335
accepts referrals from outside borough, and often outside London.
Women are nursed with their infants and the ward team is a spe- Recommendations for the use of ECT
cialized multi-disciplinary team led by the consultant psychiatrist in pregnancy: literature review and
and the ward matron. Our approach is multi-disciplinary, holisti- proposed clinical protocol
cally focusing on mother’s illness as well as its impact in the dyadic H. Ward1,2* , J. Fromson1,2 , J. Cooper3 , G. De Oliveira4,5,6 , M.
relationship of mother and infant. Almeida1,2,7
Our study aims to describe and reflect on the complex, unique 1 Brigham & Women’s Hospital, Psychiatry, Boston, USA; 2 Harvard
and often challenging dynamics that arise in the context of peri- Medical School, Psychiatry, Boston, USA; 3 University of Chicago,
natal mental illness, in a diverse ward environment. We offer Psychiatry and Behavioral Neuroscience, Chicago, USA; 4 Rhode
perspectives as psychiatrists with training in psychodynamic (Dr. Island Hospital, Anesthesiology, Providence, USA; 5 Brown University
Tsoumpris) and creative arts therapies (Dr. Alsaraf). School of Public Health, Health Services Research, Providence, USA; 6
Methods.– Our study is qualitative and takes a descriptive and Warren Alpert School of Medicine at Brown University, Surgery,
reflective approach. Providence, USA; 7 Harvard Medical School, Division of Women’s
Results.– We comment on three case studies of women and their Mental Health and Reproductive Psychiatry, Boston, USA
babies admitted on the MBU. We use a psychodynamic framework * Corresponding author.
to conceptualise the interpersonal and team dynamics that arose

when treating these patients. Background and aims.– Psychiatric disorders are common in preg-
Conclusions.– Our observations will highlight the complex inter- nancy, affecting 15–29% of pregnant women. Untreated depression
personal and relational dynamics that may occur in women and has negative consequences for mother and fetus. Electroconvul-
babies during the perinatal period and how these can impact on sive Therapy (ECT) is an effective treatment for severe depression.
the functioning of a diverse and busy MBU. However, there is no literature that consolidates the evidence on
Disclosure of interest.– The authors have not supplied a conflict of maternal and fetal risks associated with untreated depression,
interest statement. medications, and ECT and translates it into an evidence-based
protocol. In order to facilitate ECT access to perinatal patients,
we performed a literature review and propose guidelines for the
E-PP1334 administration of ECT in pregnancy.
Pattern of psychiatric illness among Methods.– A comprehensive review of the literature regarding both
ECT and psychotropic medications in pregnancy was performed,
women attending private psychiatric
including meta-analyses and all systematic reviews of use of ECT
consultation service in a rural area of in pregnancy.
Bangladesh Results.– The indication and appropriateness of ECT in pregnancy
M.M.J. Uddin1* , H.U. Ahmed2 , M.T. Alam3 , M.A. Hamid3 , F. Alam2 must be carefully weighed against the risks of untreated maternal
1 National Institute of Neurosciences and Hospital, Psychiatry, Dhaka, illness and alternative treatment options. The safety of ECT in preg-
Bangladesh; 2 National Institute of Mental Health, Child, Adolescent nancy has been well documented over the last 50 years. The adverse
and Family Psychiatry, Dhaka, Bangladesh; 3 National Institute of effects in pregnancy are similar to the risks of ECT in any individ-
Mental Health, Psychiatry, Dhaka, Bangladesh ual. The most common maternal risks are premature contractions
and preterm labor, which occur infrequently and are not clearly
caused by ECT. The rates of miscarriages are not significantly differ- the role of Iraqi women psychiatrists in providing medical
ent from that of the general population. Unlike certain medications, help.
ECT poses minimal risk to the fetus. Methods.– Related published studies, several websites and media
Conclusions.– ECT is safe and effective for management of many documents were reviewed and analyzed.
psychiatric disorders in pregnancy. Based on changes in physiology Results.– Women in Iraq suffered the plights of three successive
that occur during pregnancy, we considered recommendations for wars for the last three decades also they were direct victims of
treatment modifications and propose a protocol to improve access the acts of terror and violence during and after US-led 2003 inva-
and safety of ECT for pregnant patients. sion, killed or severely injured by airstrikes, street bombs, targeted
Disclosure of interest.– The authors have not supplied a conflict of for assassination and kidnap themselves or by proxy and no less
interest statement. than 2.5 million were forced into exile in the last 2 years, also they
are the indirect victims of lost male relatives leaving around I mil-
lion widows. This caused an increased prevalence of mental health
E-PP1336 problems. Around 1 million widows is thought to WHO reported
Tears of Ishtar: women’s mental that women form 44% of psychiatric outpatient visits, others seek
health in Iraq help from faith healers or general practitioners. The lack of finan-
M. Younis cial and social support. The number of women psychiatrists in Iraq
College of Medicine-Baghdad University, Psychiatry, Baghdad, Iraq has increased which may encourage more mentally ill women to
seek medical help.
Background and aims.– Conclusions.– Women in Iraq suffered the impact of war and
Background.– Women’s mental health in the Arab world countries violence, these psychological traumas have not been addressed
is a neglected issue in health care service and Iraq is no exception adequately.
in spite of the putative effects of war-related traumas Disclosure of interest.– The authors have not supplied a conflict of
Objectives.– This paper aims to explore the effects of succes- interest statement.
sive wars and violence on the mental health of women, and
European Psychiatry
E-Poster Viewing
E-Poster Viewing - 7–9 April: Anxiety Disorders Disclosure of interest.– The authors have not supplied a conflict of
and Somatoform Disorders interest statement.
E-PV0002
E-PV0001
“Premenstrual dysphoric disorder: a
Protective-coping behavior of
case report”
children with anxiety-phobic C. Alario Ruiz1* , C. Rodríguez Fernández1 , E. Castaño García2
disorders 1 Psychiatry, Psychiatry, Palencia, Spain; 2 Psychiatry, Psychology,
V. Abdullaeva Palencia, Spain
Department of Psychiatry, Addiction and Child Psychiatry, Medical * Corresponding author.
Psychology, Psychotherapy, Tashkent, Uzbekistan
Background and aims.– The mood in women is cyclic due to the influ-
Background and aims.– ence of hormonal systems on neurotransmission and neuropeptidic
Introduction.– Anxiety and fear syndromes are among the most systems at the diencephalic and cortical levels. 75% of women dur-
common psychopathological phenomena of childhood and adoles- ing reproductive age have mood variations, but without requiring
cence. Despite the high prevalence of anxiety-phobic disorders in any specific treatment. But those women whose symptoms cause
childhood and adolescence, they are not recognized or underesti- them disability in psychosocial functioning require early diagnosis
mated for a long time. and treatment since this pathology can disable them intermittently
Objectives.– The objectives of the investigation is to study the for a third of their lives. Premenstrual Dysphoric Disorder (PMDD)
protective coping behavior of children with anxiety and phobic is the pathological exacerbation of the somatic and psychic changes
disorders. that occur during the end of the luteal phase in the normal feminine
Methods.– During the study, we examined 35 school-age children cycle and produces physical and psychic disabilities and problems
with anxiety and phobic disorders who are on hospital treatment in family, work and social relationships. The latter is an essential
in the city children’s psychoneurological center of Tashkent. Were condition for the woman to meet DSM-5 clinical criteria.
used clinical-psychopathological, experimental-psychological and Objective.– Establish differences between Premenstrual Dysphoric
clinical-statistical methods. Disorder and other Mood Disorders.
Results.– It was revealed that the characteristic personal charac- Bibliographic review of the treatments accepted for Premenstrual
teristics of children suffering from anxiety and phobic disorders Dysphoric Disorder.
were isolation, self-doubt, dependence on others. They found ten- Methods.– We present a clinical case of a patient referred to the
sion and excitability, sometimes combined with impulsiveness. Mental Health Unit, who was considered to suffer from this disor-
They were characterized by mood instability, increased level of der.
anxiety. Depending on the structure of the family different was Results.–
the contribution of patology type of education in maladaptive pat- - The Premenstrual Syndrome (75–80% of women) differs from Pre-
terns of protective and coping behavior of children. Patology type menstrual Dysphoric Disorder (5–8% of women), which involves
of education has contributed to increasing alarming symptoms, is somatic/ affective symptoms that produces dysfunction or signif-
associated with the use of maladaptive protective mechanisms to icant disability.
escape from reality. Inharmonious type of education affects both Conclusions.– PMDD is a well-defined clinical entity with an impor-
his self-esteem and the perception of family members. tant impact on the lives of affected women. - It is necessary to
Conclusions.– Thus, children with anxiety and phobic disorders consider PMDD in the differential diagnosis of Affective and Anx-
were characterized by increased emotional excitability, frustration, ious Syndromes in women of childbearing age. - Treatment with
difficulties in the sphere of interpersonal relations. When coping SSRIs is effective - If there is no response to SSRI, it could benefit
with stress, they are prone to various substitute reactions, the con- from association with progestagens.
tent of which reflects the manifestations of aggression directed at Disclosure of interest.– The authors have not supplied a conflict of
both the other person and themselves. interest statement.
S446 E-Poster Viewing / European Psychiatry 56S (2019) S445–S778
E-PV0003 Background and aims.– Anxiety spectrum disorders is common

Dissociative pseudodementia and among patients with risks of serious arrhythmias and sudden car-
electroconvulsive therapy: a series of diac death, with an incidence of 30–40%. Among them, Torsade de
Pointes (TdP) is a Selective serotonin re-uptake inhibitors (SSRI)
two cases and review of literature rare adverse event which are recommended as first-line agents of
G. Anmella Diaz1* , P.J. Sanchez2 , A. Lladó2 , L. Pintor1 , V. Navarro1 ,
these psychiatric disorders. We aim to assess the findings in litera-
A. Gimenez1 , J. Pinzon1 , M. Sagué1 , S. Madero1 , M.T. Pons1 , A.
ture regarding management of these patients with dual diagnosis.
Stoppa3 , R. De la Mata4 , C. Llach1 , A. Benabarre1
1 Hospital Clínic of Barcelona, Barcelona- Catalonia- Spain,
Methods.– A review was conducted to clarify the mecha-
nisms associated with the occurrence of arrythmias when
Department of Psychiatry and Psychology, Barcelona, Spain; 2
using SSRI and investigating (if so) whether these alter-
Hospital Clínic of Barcelona, Barcelona- Catalonia- Spain,
ations depend on the dose. The literature search was con-
Department of Neurology, Barcelona, Spain; 3 Hospital Consorci de
ducted in PubMed data reviewing articles between 1982 and
Terrassa, Terrassa- Catalonia- Spain, Department of Psychiatry and
2018.
Psychology, Terrassa, Spain; 4 Hospital de Salamanca, Salamanca-
Results.– TdP risk increases in conjunction with other factors
Spain, Department of Psychiatry and Psychology, Salamanca, Spain
such as structural heart diseases and long QT interval and other
factors such as ECG monitoring or minimum therapeutic dose
Background and aims.– use (as this effect is dose dependent). However, this risk is not
Introduction.– Very-few literature has been published about the use complete understood, as antidepressants have also been shown
of ECT in dissociative-disorders, mostly on dissociative-identity- to have beneficial cardiologic effects due to their actions over
disorder and comorbid-depression (7 cases)1–3(ref) , and about ECT the autonomic nervous system and by their anti-arrhythmic
in depressive-pseudodementia (16 cases)4–6(ref) . We did not find properties.
literature about ECT in dissociative-pseudodementia. Conclusions.– In conclusion, when dealing with a patient suf-
Aims.– To examine the utility of ECT in dissociative- fering from symptoms of anxiety spectrum disorder and
pseudodementia. arrythmia, a clinician should not deter from considering the
Methods.– We present a series of 2-cases of dissociative- option of pharmacological treatment. The main recommenda-
pseudodementia and discuss the potential uses of ECT: tions include monotherapy using the minimum effective dose,
Case 1: 63-year-old-woman without relevant-psychiatric/ sertraline use and multidisciplinary team approach, with ECG
medical-record presented rapidly-progressive cognitive impair- monitoring.
ment presenting with absolute mutism in 1.5-years-evolution. Disclosure of interest.– The authors have not supplied a conflict of
Case 2: 46-year-old-man, without relevant-psychiatric/medical- interest statement.
record presented with insidious 5-year progressive psychomotor-
inhibition, apathic-behaviour and progressive speech decrease till
E-PV0005
absolute mutism.
In both cases, organic etiologies were discarded after several The influence of the modern standard
tests. Antipsychotic, antidepressant and anxiolytic treatments were of physical attractiveness on the
essayed without response. Both cases were admitted in psychiatry- mental health of adolescents
hospitalization-unit for ex-juvantibus ECT. considering the gender characteristics
Results.– S. Barylnik1
Case 1: after the first-ECT-session the patient presented 1 SSMU, General Medicine, Saratov, Russia
with spontaneous coherent speech, preserved orientation and
functional recovery, MMSE = 24/30, approximate-answers, high- Background and aims.– The report is devoted to the study of the
suggestibility and dissociative-amnesia. phenomenon of the standard of physical attractiveness and its
Case 2: after 16-ECT-sessions and tryciclic-antidepressant the influence on teenagers’ perception of the image of their body, as
patient presented spontaneous speech, active-behaviour and well as the proof of the relationship between the degree of dissat-
MMSE = 29/30. After 3-days of recovery there was a regression to isfaction with their appearance and the level of manifestation of
the initial clinical-state, presenting fluctuations afterwards. mental states, taking into account gender characteristics.
Both cases were diagnosed with dissociative-pseudodementia due Methods.– The following diagnostic methods were used: the ques-
to the dissociative features and unpredictable-situation-dependent tionnaire “The own body image” (OBI) and the scale of “satisfaction
fluctuating clinical evolution. Outpatient follow-up supported the with one’s own body” (SSOB) by O.A. Skugarevsky, thanks to which
diagnostic-orientation. the comparative analysis of the degree of dissatisfaction in boys
Conclusions.– Both cases showed an unexpected, rapid and and girls was made; and its correlation with indicators of the main
clinically-substantial response after ECT. Thus, ECT permitted a mental states (Eysenck test).
diagnostic-orientation and showed therapeutic potential in these Results.– Using the OBI questionnaire, we found the number of boys
two complex cases, in line with literature reports. Therefore, in who are adequately perceive their body image is much bigger than
selected cases with dissociative-disorders and pseudodementia, girls (adequate attitude to appearance - 16.4% of boys and 9.4% of
ECT should be considered as a valid diagnostic and therapeutic tool. girls), the number of boys with a strong degree of dissatisfaction is
Disclosure of interest.– The authors have not supplied a conflict of much less than girls (strong dissatisfaction with 13.1% of boys and
interest statement. 29.7% of girls).
Conclusions.– As a result of the study, data were obtained that con-
firmed the hypothesis and allowed the following conclusions. Most
E-PV0004 adolescents, indeed, are concerned about the mismatch of their
Narrative review regarding anxiety physical parameters with those universally recognized in society.
spectrum disorders management in Note that the boys show no less interest in this problem than the
girls, which was unusual for them earlier. Violation of the OBI is
patients with arrythmia
a condition in which a person believes that they look worse than
A. Ballesteros Prados1* , A.S. Rosero Enriquez2 , F. Inchausti3
1 they really are.
Osasunbidea, Psychiatry, Estella, Spain; 2 Osasunbidea, Psychiatry,
Pamplona, Spain; 3 RiojaSalud, Psychiatry, Logroño, Spain
E-Poster Viewing / European Psychiatry 56S (2019) S445–S778 S447
E-PV0006 to investigate relationships between language self motivational

Psychological characteristics of systems and linguistic intelligence with language anxiety among
women with non-psychotic mental bilinguals.
Methods.– The research method was correlation. 250 bilinguals
disorders in perimenopause period (Persian – English) students were selected and responded to Gard-
M. Belokrylova1* , E. Epanchintseva2 , N. Garganeeva3 , I.
ner’s linguistic intelligence questionnaire, Papi’s language self
Belokrylov4 , V. Maltsev2
1 Mental Health Research Institute- Tomsk National Research
motivational systems inventory and Horwitz’s language anxiety
inventory. The data were analyzed by Pearson correlation formula.
Medical Center- Russian Academy of Sciences, Borderline States
Results.– The results showed that there is negative and significant
Department, Tomsk, Russia; 2 Mental Health Research Institute-
relationship between components of language self motivational
Tomsk National Research Medical Center- Russian Academy of
systems (ideal self, real self, purposive effort and learning experi-
Sciences, First Clinical Psychiatric Unit, Tomsk, Russia; 3 Siberian
ence), and also linguistic intelligence with language anxiety among
State Medical University, Department of General Practice and
bilinguals.
Polyclinical Therapy, Tomsk, Russia; 4 Mental Health Research
Conclusions.– Considering the main role of linguistic intelligence
Institute- Tomsk National Research Medical Center- Russian
and language self motivational systems in emergence of language
Academy of Sciences, Addictive States Department, Tomsk, Russia
anxiety, it should be important for the teachers and professors
to notice the role of teaching methods and cultural differences in
Background and aims.– Women during perimenopause quite often learning process especially second or foreign language learning.
address the psychiatrist with various symptoms that increases Disclosure of interest.– The authors have not supplied a conflict of
importance of timely qualified interdisciplinary care. Objective: interest statement.
to study psychological characteristics of women who addressed
the psychiatrist during perimenopause concerning non-psychotic
E-PV0008
mental disorders.
Methods.– 117 women who came to psychiatric clinic at the age Drug-drug interactions in common
of 40–65 years were examined. Clinical-psychopathological, psy- mental disorders patients attended in
chological (technique of measurement of anxiety level by Taylor; primary health care
TAS-26 scale; menopausal index), statistical methods were used. T. Borges1* , A. Inocenti Miasso1 , K. Graziani Giacchero Vedana2 , L.
Results.– In the group of examined women 58.12% had neu- Moscovici3 , E. Cristina Dias Castilho2
rotic, stress-related, 9.4% - somatoform, 6.84% - affective, 25.64% 1 Centro Universitário Estácio de Ribeirão Preto, Health Department,
- organic non-psychotic disorders. In the subgroup of women (1) Ribeirao Preto, Brazil; 2 University of Sao Paulo, Psychiatric Nursing
in menopause and postmenopause (n = 69) a higher frequency of and Human Sciences, Ribeirão Preto, Brazil; 3 Centro Universitário
organic disorders, than in the subgroup of women (2) in pre- Estácio de Ribeirão Preto, Health Department, Ribeirão Preto, Brazil
menopause (n = 48) was revealed (6-fold). The latter were 1.7 times * Corresponding author.
more often hospitalized with neurotic disorders. Significant dif-
ferences in menopausal index were not revealed. In subgroup 1 Background and aims.– Studies in Brazil show around 50% of the
in 30% the period from the beginning of menopause lasted till 49 people attended in Primary Health Care (PHC) have Common
years of age. In 37.1% of them organic disorders were diagnosed; Mental Disorders (CMD). High prevalence of CMD in PCH can
40% - neurotic, stress-related; 14.3% - somatoform; 8.6% - affective lead to psychotropic prescription. It’s seen usually CMD patients
disorders. Across indicators of anxiety, alexythymia, menopausal have more number of medication prescribed than those who are
index they did not differ. The analysis of anxiety in 47 women negative to CMD what increases the chance of potential drug-
with “alexythymic” type of personality and 70 without alexythymia drug interaction (DDI). PHC plays an important role in Brazilian
revealed statistically significant differences (p < 0.001). About 60% health assistance to CMD patients; however, there are few stud-
of total group had high level of anxiety with which the fre- ies regarding DDI in CMD patients in PHC settings. Considering
quency of identification of “alexythymic” type of personality the relevance of such context to patient safety, the objectives
correlated. of this study were: to compare the frequency and characteriza-
Conclusions.– Thus, the relevance of identification of levels of tion of potential DDI among patients with and without Common
anxiety and alexythymia in women for development of psychocor- Mental Disorders, and to verify whether there is correlation of
rectional programs was confirmed. the CMD with potential DDIs, demographic, use of psychoactive
Disclosure of interest.– The authors have not supplied a conflict of drugs, number of medication prescribed and severity of potential
interest statement. DDIs.
Methods.– This is a quantitative, cross-sectional and descrip-
tive correlational study carried primary health care services
E-PV0007 in Brazil. Sample: among 430 patients interviewed 190 had
Correlation between language self more than two medications prescribed. Measurements: uni-
variate and multivariate analysis having CMD as dependent
motivational systems and linguistic
variable.
intelligence with language anxiety Results.– 58.4% had DDI and 53.1% had CMD. Associations were
among bilinguals found between age, monthly income psychotropic medication and
S. Bialayesh1* , A.R. Homayouni2 , M. Nasiri Kenari3 severity of DDI with CMD58.4% had DDI and 53.1% had CMD. Asso-
1 MA in Psychology, Iran; 2 Department of Psychology, Bandargaz ciations were found between age, monthly income psychotropic
Branch- Islamic Azad University- Bandargaz- Iran, l, l, Iran; 3 MA in medication and severity of DDI with CMD.
Psychology-, l, l, Iran Conclusions.– The results found highlights the risk for DDI of CMD
patients emphasizing the urgent need of the investigation and
implementation of strategies aiming this public.
Background and aims.– Foreign language class can be largely anx-
ious to learners. Language Anxiety is the feeling of tension, fear
interest statement.
and apprehension associated with such foreign language con-
texts as speaking, listening and learning. Many language learners
suffer from anxiety about their learning. So, the research aimed
E-PV0009 objective, MMPI method was used, where the range between 30
State- trait anxiety as predictor of and 70 T-scores indicated normal psychological condition, while
procrastination in students and increased score by one or several clinical scales were deemed to
signal the pathological profile.
employees Results.– Analysis of averaged subject profiles showed that in most
V. Barabanshchikova, F. Sultanova, A. Kachina, E. Ognyannikova, D.
subjects the average profile score exceeded 80 T-scores, and namely
Boyarinov*
in 64% FC patients, 60% IBS-M patients and 56% IBS-C patients vs.
Moscow State Lomonosov University, Faculty of Psychology, Moscow,
44% IBS-U patients, 43% IBS-D patients and 33% FD patients, p < 0,01.
Russia
The average profile above 70 T-scores, but below 80 T-scores by one
or several clinical scales was observed in 50% for FD vs. 32% for
Background and aims.– The present paper is devoted to the study of IBS-D; p < 0,01; and twice as often for IBS-C: 33% vs. 16% for FC. In
procrastination in students and employees. This work aims to indi- the lower part of continuum, where the psychological factor influ-
cate and analyze the procrastination of students and employees, ence is relatively low, the profile distribution was as follows: 25%
including the correlation between the procrastination manifesta- for IBS-D, 20% for FC and IBS-M, 17% for FD and IBS-M, 11% for
tion and state- trait anxiety. IBS-C.
Methods.– Subjects fulfill a standardized test booklet: the Gen- Conclusions.– The data obtained demonstrate the significant spe-
eral Procrastination Scale test (Lay & Silverman, 1996), the State- cific gravity of psychosomatic component in disease development,
Trait Anxiety Inventory (Spielberger, 1976). In the present study, progression and chronization in patients with FC, IBS-M.
the index of procrastination level was a dependent variable whilst Disclosure of interest.– The authors have not supplied a conflict of
the personal characteristics- state- trait anxiety- independent vari- interest statement.
ables.
Results.– Significant difference was found between students of dif-
E-PV0011
ferent year of education only in trait anxiety. This difference may
be due to the fact that in the exams the level of anxiety rises. A lin- Pain and depression in rheumatic
ear regression model of academic procrastination (adj. R2 = 0,469; patients
p = 0,0001) showed that academic procrastination is determined by N. Chernus1* , R. Gorenkov2 , S. Sivkova1 , A. Sivkov3 , A.
state of anxiety (ˇ = 0,191; p = 0,025). The level of anxiety is high Zolotovickaja1 , T. Savina1
among student during the exams, as it requires a lot of effort. And
high anxiety links with such counterproductive coping strategy as Care Department, Moscow, Russia; 2 I.M. Sechenov First Moscow
procrastination. State Medical University, Higher Healthcare Organization
Conclusions.– At the moment the research continues. There are dif- Management, Moscow, Russia; 3 I.M. Sechenov First Moscow State
ferences between the procrastination of students and employees, Medical University, Department of Clinical Pharmacology and
because they have different motivation and activities. Differences Internal Diseases Propaedeutics of the Medical Faculty, Moscow,
in the level of traits anxiety may be due to the fact that the Russia
exams for students is stress factor. Employees may experience
anxiety due to high level of responsibility or heavy workload. In
the future, we want to analize the predictors of procrastination Background and aims.– Chronic recurrent pain is a clinical symptom
among students and employees. Such research may suggest ways to of rheumatic diseases with primary joint damage. The mechanisms
reduce the level of anxiety and procrastination for provide high job of chronic pain syndrome development are often associated with
performance. depression.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– The study enrolled 67 patients with ostheoarthrosis
interest statement. (OA), rheumatoid arthritis (RA) and lower back pain. The average
subject age was 59, 5 ± 5, 3; 24 were males and 43 were females.
In order to achieve the study objective, Luscher test, CES-D; TAS;
E-PV0010 Spielberg-Hanin’s scale; MMPI; VAS scale and McGill Pain Ques-
tionnaire were used.
Analysis of actual psychological
Results.– Following the testing results, 32 (47,8%) of 67 patients
condition in patients with functional were diagnosed with chronic pain syndrome associated with
intestinal disorders depression respectively p = 0,002. The average pain syndrome (PS)
N. Chernus1* , R. Gorenkov2 , S. Sivkova3 , A. Sivkov3 , A. level by VAS scale in patients with depression was almost 1,7 times
Zolotovickaja1 , T. Savina1 higher than in patients without psychological disorders, 8,6 ± 0,9
vs. 5,2 ± 1,09; p < 0,001. Under adaptive tension conditions, when
Care Department, Moscow, Russia; 2 I.M. Sechenov First Moscow the MMPI profile exceeded 70 T-scores, PS tended to exacerbate
State Medical University, Higher Healthcare Organization (p < 0,001), while manifestation of depression symptoms corre-
Management, Moscow, Russia; 3 I.M. Sechenov First Moscow State lated with PS (г = 0,627) and the presence of personality traits
Medical University, Department of Clinical Pharmacology and accentuation (г = 0,531), along with increased anxiety (г = 0,425),
Internal Diseases Propaedeutics of the Medical Faculty, Moscow, asthenic condition (г = 0,392) and general TAS alexithymia score
Russia (г = 0,473). After the course of therapy involving antidepressant
drugs, PS decreased by 2,9 times as compared to the baseline level,
p < 0,001.
Background and aims.– Phenomenon of psychological mecha-
Conclusions.– Indications for antidepressant use in patients with PS
nisms specific gravity/significance determination in the pathologic
include the chronic pain syndrome associated with depression at
behavior of functional intestinal disorders of various forms has
the background of basic anti-inflammatory therapy.
claimed attention from physicians and psychologists for the more
than 40 years.
interest statement.
Methods.– The study enrolled 114 patients (26 male and 88 female)
with irritable bowel syndrome (IBS-D, IBS-C, IBS-M and IBS-U),
functional constipation (FC) and functional diarrhea (FD). The aver-
age subject age was 43,6 ± 11 years. In order to achieve the study
E-PV0012 obsessive-compulsive symptoms and their relation to personality

Psychosomatic aspects of adaptation dimensions in OCD and GAD.
development in gastroenterological Methods.– Symptoms were measured by the Symptom Question-
naire “O” (derived from SCL-90-R Questionnaire) and personality
patients. Prospective study traits were described by 16 PF Cattell Inventory. In the study the
N. Chernus1* , R. Gorenkov2 , S. Sivkova1 , A. Sivkov3 , A.
variance analysis, multiple regression analysis and correlation anal-
Zolotovickaja1 , T. Savina1
ysis were applied. In the study were included additional variables:
sex and occurence of some cognitive dysfunctions described by
Care Department, Moscow, Russia; 2 I.M. Sechenov First Moscow
Bender and Benton tests.
State Medical University, Higher Healthcare Organization
Results.– The analysis of variance didn’t revealed any significant
Management, Moscow, Russia; 3 I.M. Sechenov First Moscow State
differences in intensity of personality dimensions (described by
Medical University, Department of Clinical Pharmacology and
the 16 PF Cattell Inventory) in patients with OCD and GAD.
Internal Diseases Propaedeutics of the Medical Faculty, Moscow,
Some of the measured personality dimensions were associated
Russia
with sex, occurrence of cognitive dysfunctions and interac-
tion of variables: clinical diagnosis, sex, cognitive dysfunctions.
Background and aims.– Studying the clinical significance and inter- The study revealed some significant differences in relationships
relations of psychovegetative, immunological micro-ecological between obsessions, compulsions and personality traits in OCD and
system disorders as different levels of disturbance of normal GAD.
body adaptive response to disease is the relevant research Conclusions.– The study supports the thesis that obssesions and
topic. compulsions observed in OCD and GAD may be associated with
Methods.– The study included 674 patients with various gastroen- different personality traits.
terological pathologies (average age 38,5: 136 males, 517 females), Disclosure of interest.– The authors have not supplied a conflict of
who had been followed-up from 2,5 to 15 years. All the subjects interest statement.
underwent standard gastroenterological examination. In order to
achieve the study objective, the patients were also subject to micro-
E-PV0014
biological, immunological and psychovegetative tests, and namely:
Spielberg-Hanin’s scale, Lusher test, CES-D, TAS, MMPI; diagnostic Panic attack in the emergency service:
criteria for panic attacks and chronic pains, VAS scale and McGill sample description
Pain Questionnaire. M. Cotter* , F. Pontes, S. Casinhas, A. Carvalho
Results.– Obtained results allowed to identify the stages of disease Centro Hospitalar Médio Tejo, Psiquiatria, Tomar, Portugal
recovery and early rehabilitation period, where psychovegetative
condition of patient was the basic system with correction period of
2,5-6 months; at this background, the pain syndrome management Background and aims.–
duration tends to decrease r = 0,672, p < 0,01; while the microbio- Introduction.– The panic attack is a sudden episode of severe
logical system recovery is determined by the correlation between anxiety, fear or discomfort that leads to physical and emotional
the psychovegetative, large intestine movement r = 0,459, p < 0,05, symptoms. These can take the form of palpitations, chest pain or
as well as pre- and probiotic therapy within the period from 7 discomfort, choking or smothering feelings, dizziness, feelings of
months to 1,2 years; immunological status correlated with psy- unreality, dyspnea, paresthesia, hot flushes, sweating, faintness,
chovegetative and micro-ecological status r = 0,498, p < 0,01, and trembling or fear of dying/going mad.
did not require any correction. Often associated with a sense of impending doom, these symptoms
Conclusions.– The study conducted identified the specific gravity of can be similar to symptoms of a heart attack or stroke, leading these
each system influence during disease recovery and early rehabili- patients to emergency service regularly.
tations as part of the body adaptive response to disease. The duration of the attack may vary from less than one to sev-
Disclosure of interest.– The authors have not supplied a conflict of eral hours taking usually about 10 to 20 minutes, being potentially
interest statement. caused by something frightening or just no reason at all.
We have tried to establish the prevalence of panic attacks in
patients who resort to the emergency department. We also sought
E-PV0013 to characterize the cohort of patients with panic disorder in terms of
social-demographic, psychiatric co-morbidity, treatment and guid-
Obsessive-compulsive symptoms and
ance.
personality traits in patients with Treatment for panic attacks involves psychological therapy, medi-
diagnosis of obsessive-compulsive cation, or both.
disorder (OCD) and generalized Objectives.– With this study, the authors wanted to characterize
anxiety disorder (GAD). the patients who went to the Psychiatric Emergency Service of the
A. Citkowska-Kisielewska* , K. Rutkowski, M. Mielimaka,
˛ J.A. Centro Hospitalar Médio Tejo (CHMT) during 2016 due to panic
Sobański, E. Dembińska attack, taking into account socio-demographic data, type of crisis,
Jagiellonian University Collegium Medicum, Department of treatment and further outcome.
Psychotherapy, Kraków, Poland Methods.– Retrospective study of data from the clinical trials of
* Corresponding author. patients who were referred to the CHMT emergency department
for panic attack.
Background and aims.– Obsessive-compulsive symptoms are Results.– Work in progress.
predominant symptoms in OCD, but often coexist in other Conclusions.– Work in progress.
mental disorders, such as anxiety disorders. Clinical practice Disclosure of interest.– The authors have not supplied a conflict of
and research data indicate that similar symptoms occuring interest statement.
in different mental disorders may have different quality and
etiology.
A study was conducted in two groups of patients: 76 with diagnosis
of OCD and 186 with diagnosis of GAD, aged 18-58, who reported
for treatment at the Day Ward. The aim of the study was to asses
E-PV0015 and Dermatology indicate that there’s no alopecia. She says that
Assesment of the quality of treatment she can not stop thinking about this defect and does not believe
in patients with somatoform that she has normal hair. This fact generates a lot of anxiety and
discomfort. Maintains work life, few social relations. The exami-
disorders at the prehospital level nation shows a normal hair without referred alopecia areas. Mild
E. Navasardyan1 , M. Artemieva2 , I. Danilin2* , R. Suleymanov2 , A.
cognitive and somatic anxiety. Isolation. Insomnia for early awak-
Lazukova2 , I. Belokrylov2 , V. Sokolov2 , Z. Niewozinska3
1 Z. P. Solovyov Scientific and Practical Psychoneurological Center,
ening. Clinical judgment: Overrated idea that is near delirious in an
obsessive personality. Body dysmorphic disorder.
Moscow Healthcare Department, Moscow, Russia; 2 Peoples’
Conclusions.– According to the ICD-10, body dysmorphic disorder is
Friendship University of Russia RUDN University, Department of
classified into somatoform disorders. On the other hand, the DSM-V
Psychiatry and Medical Psychology, Moscow, Russia; 3 N.I. Pirogov
classifies it as a type of disorder within the obsessive spectrum, with
Russian National Research Medical University, Moscow Scientific and
a psychotic variant classified as a somatic delusion. Dysmorpho-
Practical Center of Dermatovenereology and Cosmetology, Moscow,
phobia is a sensoperceptive disorder in which the patient strongly
Russia
believes in the physical nature of the disorder, although it is still
considered mostly within the neurotic spectrum of diseases.
Background and aims.– To evaluate the quality of treatment of Disclosure of interest.– The authors have not supplied a conflict of
patients with somatoform disorders at the prehospital level. interest statement.
Methods.– The questionnaire revealed the duration and quality of
treatment of patients with somatoform disorder at the prehospital
E-PV0017
level. It consisted of questions assessing: the duration of treat-
ment by doctors of other specialties, frequency of appointment THe impact of anxiety on the course of
of psychotropic therapy by doctors of other specialties, quality of hypertension
appointment of psychotropic therapy, and revealed the frequency S. Ellini1 , N. Ghazouani2* , Y. Jemli1 , A. Rebai2 , M. Cheour1
1 Razi University Hospital, Psychiatry, Manouba, Tunisia; 2 Medical
of doctors of other specialties refer patients with somatoform dis-
order to a psychiatrist. 110 people (from 20 to 55 years) were School of Tunis, Psychiatry, Tunis, Tunisia
included, including 67 women and 43 men with somatoform dis-
orders.
Results.– 49 patients were prescribed psychotropic drugs by doc- Background and aims.– High blood pressure is a chronic disease that
tors of other specialties (44.5%), 61 patients were not prescribed constitutes a public health problem. In spite of the high prevalence
psychotropic drugs (55.5%). 41 patients out of 49 patients psy- of anxiety in patients with hypertension, screening for anxiety in
chotropic drugs were prescribed by neurologist (83,7%), 8 - by patients with hypertension is not yet systematic.
therapist (16,3%). 37 patients did not get effect of therapy (75.5%), This study aims to find out whether the co-occurring of hyperten-
12 patients got insignificant effect of therapy (24.5%). Doctors of sion and anxiety worsens the course of hypertension.
other specialties recommended to consult with the psychiatrist to Methods.– This was a cross-sectional, descriptive and analytical
84 patients (76,4%). study among patients diagnosed with hypertension consulting a
Conclusions.– 56,4% treated their somatoform disease at the doc- basic health center in the governorate of Manouba in Tunisia. The
tor of other specialty from 1 to 3 months. Most often psychotropic assessment of anxiety was done using the Hospital Anxiety and
drugs were prescribed by a neurologist (83,7%). 16.3% patients psy- Depression Scale (HAD-S).
chotropic drugs were prescribed by the therapist. Most patients Results.– One hundred patients diagnosed with hypertension were
(75.5%) did not get the effect of the prescribed psychotropic ther- included in the study. The prevalence of anxiety in patients with
apy. 75% of patients were recommended by neurologist to consult hypertension was 58%. Anxiety was significantly associated with
with a psychiatrist, as a rule, after the appointment of ineffective poor adherence to treatment with p value inferior to 0.01. The use
therapy. of polytherapy for hypertension was also associated with anxiety
The publication was prepared with the support of the “RUDN Uni- with p value of 0.06.
versity Program 5-100”. Neither of the following factors was associated with anxiety: the
Disclosure of interest.– The authors have not supplied a conflict of quality of follow up (p = 0.124) treatment resistance (p = 0.97), the
interest statement. change of the therapeutic class during the course of the disease
(p = 0.088), the presence of adverse affects related to current anti-
hypertensive treatment (p = 0.9), the occurrence of adverse events
E-PV0016 that motivated the change of treatment in the past (p = 0.45) and
the therapeutic response (p = 0.68).
Dismorphophobia: between neurosis
Conclusions.– The results of our study put under a spot of light the
and psychosis need for a multidisciplinary management of hypertension taking
L. Gallardo Borge* , E. Rodríguez Vázquez, C. Capella Meseguer, M. into account the role of psychological distress as a worsening factor
Gómez García, M. De Lorenzo Calzón, N. De Uribe Viloria, P. of the course of this disease.
Marqués Cabezas Disclosure of interest.– The authors have not supplied a conflict of
Hospital Clínico Universitario, Psychiatry, Valladolid, Spain interest statement.
Background and aims.– Dismorphophobia is the dissatisfaction with

E-PV0018
one’s body, feeling it as anomalous or deformed in one of its fea-
tures. This generates a deep discomfort, even when there are no Quality of life in panic disorder: the
objective nor observable reasons to assess their physical appear- effect of clinical features and
ance in those terms. personality traits
Methods.– Descriptive study of a clinical case and literature review. C. Gitahy Falcao Faria* , R. Christophe Freire, M. Fidry, M. Costa do
Results.– A 31-year-old woman, single. With no psychiatric history. Cabo, A. Egidio Nardi
Initiates referral from primary care for anxiety. She related her hair Federal University of Rio de Janeiro, Laboratory of Panic and
loss two years ago after a treatment for acne and ferropenia, start- Respiration, Institute of Psychiatry, Rio de Janeiro, Brazil
ing to think later that she has baldness, even though Endocrinology * Corresponding author.
Background and aims.– Panic Disorder (PD) is an anxiety disorder, interact with each other and teacher with students when they are
known for its negative impact on patients’ quality of life (QoL), under stress.
while some personality traits may also have influence on QoL. Disclosure of interest.– The authors have not supplied a conflict of
The QoL measurement has been increasingly used as an outcome interest statement.
measure in clinical trials, in health technology assessment, and in
epidemiological surveys to assess the subjective health and well-
being of the population. The aim of the study is to identify which E-PV0020
clinical features and personality traits are associated to the QoL in The concept of “psychological
PD patients. mediation”
Methods.– We recruited 98 patients with the diagnosis of PD
(Vygotsky-Lurya-Zeigarnik School) in
(72 women). The mean age was 38.4 (SD: 11.6) years. Most of
the patients had one or more previous treatments (53.6%). The respiration regulation in
brief version of the World Health Organization Quality of Life hyperventilation patients and healthy
Questionnaire (WHOQOL-BREF) and Big Five Inventory were used persons
respectively to access QoL and personality traits. The correlation J. Koniukhovskaia* , E. Pervichko
strength was measured with Spearman’s correlation. We also per- Lomonosov Moscow State University, Psychology, Moscow, Russia
formed multiple linear regressions, considering demographic data, * Corresponding author.
scores from clinical scales as independent variables and QoL scores

as dependent variables. Background and aims.– The Clinical Psychology of Corporeality
Results.– WHOQOL-BREF scale means were: physical (mean: 37; (Tkhostov, 2002; Nikolaeva, Arina, 1998, 2009) suggests viewing
SD: 17), psychological (mean: 41; SD:19), social (mean: 47; SD:22), the body not exclusively as a ‘natural’ biological function, but also
environmental (mean: 45; SD:14) General perception of QoL as a culturally mediated and regulated process similar to the higher
(mean:49; SD:26) and general satisfaction with personal health. mental functions in Cultural-Historical Approach Vygotsky-Lurya-
(mean: 32; SD: 23). ZeigarnikSchool.
Conclusions.– Depressive symptoms had a strong negative correla- The regulation of breathing is both an autonomous and a voluntary
tion with QoL, and to a lesser extent, panic and anxiety symptoms function, what permits to research respiratory regulation through
were also negatively correlated to the QoL. While consciousness, psychological mediation.
extraversion and agreeableness had a mild positive correlation with Aims.– To show the role of psychological mediation at the dysfunc-
QoL, neuroticism had a strong negative correlation with QoL. tion of respiration regulation.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– The psychological mediation is assessed through: a) the
interest statement. respiratory experience interviews, b) the anxiety level, c) psychose-
mantic techniques.
The capability of voluntary respiration regulation is examined
E-PV0019 through breath holding.
What is foreign language anxiety? The study involves 20 patients with hyperventilation syndrome
(HVS) and 20 healthy participants.
explanations and strategies to reduce
Results.– The patients, on the contrary of the healthy participants,
the anxiety have less ability to hold breath. The breath holding provokes the
S. Homayouni* , S. Karbalaii hyperventilation symptoms at 55% of patients. The interview about
National Center for Development of Exceptional Talents- the respiratory experience revealed that the patients have more
Mazandaran Province- Babol City, l, l, Iran chronic disorders, panic attacks, phobias and smoking habit in
comparison to the healthy volunteers. The short breath holding is
correlated with a higher anxiety level, a larger vocabulary of neg-
Background and aims.– Language is the most thinking tool for com-
ative breathing experience and the fixation on present unpleasant
munication among human beings and human societies. The need to
sensations, described by emotional, but not bodily words.
learn a foreign language (especially English language as an interna-
Conclusions.– The negative interpretation of breathing sensation at
tional language) is increased to communicate with other countries
patients, who have HVS, leads to less breathing control. Thus, the
and cultures. In process of foreign language, anxiety is the main
psychological mediation is connected with respiration regulation
factor that may lead to psychological problems. Since anxiety has
and allows to identify the altered breath meaning and formulate
been found as a vital factor affecting language learning (Horwitz
the goals of psychotherapy.
et al., 1986).
Methods.– The research method was descriptive.
interest statement.
Results.– In Horwitz’s et al. definition (1986), foreign language
anxiety has three components; communication apprehension, test
anxiety, fear of negative evaluation. They defined communica-
E-PV0021
tion apprehension as a type of shyness characterized as fear
of, or anxiety about communicating with people. Test anxiety Psychological factors of provoking
refers to the experience of anxiety in foreign language class somatic sensations in the real and
that students normally face in exams. It is a sensitive situation false biofeedback experiment
where students are expected to succeed or failed. Fear of neg- M. Kovyazina1* , E. Rasskazova2 , J. Migunova2 , N. Varako2
ative evaluation is the apprehension about others’ evaluations, 1 Moscow State University, Psychology, Moscow, Russia; 2 Moscow
avoidance of evaluative situations that may occur in any social State University, Clinical psychology, Moscow, Russia
evaluation. * Corresponding author.
Conclusions.– To reduce the anxiety in foreign language class it is

advised the language learners to work on listening ability with for- Background and aims.– Cognitive factors of somatoform disor-
eign language, speak face to face with native speakers and gain the ders include attention to bodily sensations, catastrophizing and
experience in real situation with target language, slow the rate of somatosensory amplification (Rief et al., 1997, Martinez et al.,
the conversation, not worrying for make mistake in communicating 1999). Biofeedback experiment provokes attention to the body
with others. In schools, teachers’ approach and teaching method is whereas false biofeedback models a situation where external infor-
effective in this field. In foreign language classes learners should mation and introspective sensations are mismatched, so bodily
sensations in a false biofeedback can indicate difficulties in intro- E-PV0023

ceptive sensitivity. Psychotherapy anxiety and phobic
The aim was to reveal differences between real and false biofeed-
disorders
back in provoking bodily sensations in the head and neck in healthy
O. Kudinova* , T. Chorna
participants as well as cognitive factors of such provocation.
Kharkiv Medical Academy of Postgraduate Education, Psychotherapy,
Methods.– 33 subjects (12 males, 18-25 years old) undergoing
Kharkiv, Ukraine
biofeedback experiment including randomized false and real con- * Corresponding author.
ditions were instructed that “typically people in experiment have
sensations in head and neck” to provoke bodily attention, then filled Background and aims.– The aim of the study: the development of
Screening for somatoform symptoms (Rief, Hiller, 2003), Cognitions a comprehensive system of psychotherapy and psychocorrection
About Body and Health Questionnaire (Rief et al., 1998). of anxiety disorders of neurotic case, based on the study of their
Results.– Bodily sensations were more likely to occur in a true clinical structure and peculiarities of emotional damages.
biofeedback (58,3%) and less likely – in a false biofeedback only Scope and contributing research: 100 patients with diagnos-
(18,8%) but didn’t depend on cognitive factors. Subjective appraisal tic categories: F41.0 - Panic disorder (episodic paroxysmal
of success in regulation of bodily functions in false BFB was higher in anxiety, F41.1-Generalized anxiety disorder, F41.2-mixed anxiety-
those who reported sensations in the experiment (F = 5,34, p < 0,05, depressive disorder who are on the examination and treatment at
2 = 0,28). the psychiatric unit. A control group included 40 patients.
Conclusions.– Attention to bodily sensations accompanied by Methods.– Spielberger, Eysenck Personality Questionnaire (EPQ),
external proof for such sensations (real biofeedback) are factors The Hamilton Rating Scale for Depression (HRSD), The study of
provoking sensations in more than half of healthy participants accentuation of personality by K. Leonhard.
regardless their cognitive vulnerability to somatoform disorders. Results.– We performed the exploration of the peculiarities of
Discrepancy between external and internal stimulation attenuate clinical anxiety and patterns of therapeutic effect, based on the
this effect. Research is supported by the Russian Foundation for influence of short-term group and individual psychotherapy in the
Basic Research, project No. 17-29-02169. treatment of anxiety disorders, and evaluation the effectiveness of
Disclosure of interest.– The authors have not supplied a conflict of its reconition. The development of the methodology of applying a
interest statement. short-term group and individual psychotherapy in the treatment
of anxiety disorders based on combination relaxation, hypnosis,
cognitive-behavioral teqniques in combination on with short-term
E-PV0022 group therapy. In fact, this is a new real model psychotherapy
Cognitive factors of bodily sensations: based on integrative principles. The higt efficacy was shown in 82%
priming in provocation of sensations patients, compared with 54% efficacy in control group patients.
in healthy subjects Conclusions.– We will offer a new comprehensive methodology
M. Kovyazina1* , E. Rasskazova2 , J. Migunova2 , N. Varako2 in the treatment of anxiety disorders of neurotic case that will
1 Moscow State University, Psychology, Moscow, Russia; 2 Moscow improve the therapeutic efficacy of the treatment process, reduce
State University, Clinical Psychology, Moscow, Russia the time of treatment, reduce the period of drug therapy.
interest statement.
Background and aims.– Psychosomatics suggest two mechanisms
for epidemiology of unexplained bodily complaints in somatoform
disorders: according to “general sensitivity” the key role in soma- E-PV0024
tization is played by the attention to sensations whereas in bodily Group psychoeducation ‘drop it’
function regulation model (Tkhostov, 2002) sensations depend on decreases repetitive negative thinking
their subjective meaning.
in major depression and generalized
The aim was to reveal cognitive factors of positive and negative
priming of somatic sensations that are typical for patients with anxiety disorder
somatoform disorders. R. Rogiers1 , C. Baeken1 , D. Van den Abbeele2 , R. De Raedt3 , E.
Methods.– In 36 healthy controls (15 men, 18–25 years old) during Watkins4 , J. Remue5 , R. Colman6 , G. Lemmens5*
1 Ghent University, Dept. of Psychiatry, Ghent, Belgium; 2 Psychiatric
the task of self-regulation using the biofeedback method, atten-
tion was drawn to sensations in the head and neck with one of Center Ghent-Sleidinge, Depression and Anxiety Unit, Ghent,
three instructions (emphasizing the neutral, positive and negative Belgium; 3 Ghent University, dDepartment of Experimental Clinical
personal meaning of sensations). For example, positive instruc- and Health Psychology, Ghent, Belgium; 4 University of Exeter,
tion included description of people having sensations as “open, College of Life and Environmental Sciences, Exeter, United Kingdom; 5
conscious, empathetic and intellectual”. They filled Screening for Ghent University Hospital, Dept. of Psychiatry, Ghent, Belgium; 6
somatoform symptoms (Rief, Hiller, 2003), Cognitions About Body Ghent University, Department of Biostatistics, Faculty of Medicine
and Health Questionnaire (Rief et al., 1998). and Health Sciences, Ghent, Belgium
Results.– In 50% of respondents general attention led to sensations
in a head and a neck. The risk was higher at the persons inclined Background and aims.– Repetitive negative thinking (RNT) is con-
to somatization (F = 4,27, p < 0,05, 2 = 0,12) and considering their sidered as an important transdiagnostic factor in the onset, course
body as weak and vulnerable (F = 3,32, p < 0,08, 2 = 0,10). Both pos- and recurrence of both depressive and anxiety disorders. This study
itive and negative personal meaning increased the probability of aimed to investigate whether a group psychoeducation (GP) would
provocation (2 = 9,52, p < 0,05, Cramer’s V = 0,36), especially in per- improve RNT, anxiety and depressive symptoms, quality of life
sons with a tendency to catastrophize bodily sensations (F = 4,18, and self-esteem of patients with Major Depressive Disorder (MDD)
p < 0,05, 2 = 0,22). and/or Generalized Anxiety Disorder (GAD).
Conclusions.– Any personal meaning of sensations increased the Methods.– Eighty patients were randomized to group psychoeduca-
probability of provocation, especially in persons with a tendency tion (GP; n = 45) or waiting list control (WLC; n = 35). Assessments
to catastrophize bodily sensations. Research is supported by the took place before randomization and 12 weeks later (after treat-
Russian Foundation for Basic Research, project No. 17-29-02169. ment). Multiple linear regression analyses adjusted for baseline
Disclosure of interest.– The authors have not supplied a conflict of scores were conducted.
interest statement.
Results.– Although all outcomes improved after participation in Background and aims.– Epilepsy is an illness with expressed socio-
GP, only the uncontrollability of rumination (p = 0.03), worrying psychological consequences. A part of the difficulties faced by
(p = 0.002), distancing oneself from one’s thoughts (p = 0.003) and patients lies in the sphere of social interaction. One of the fun-
quality of life (p = 0.02) remained statistically significant after Bon- damental reasons for the alienation of female patients with this
ferroni correction compared to the WLC. Limitations of the study diagnosis is the presence of familial, personal, and motherhood-
included the small sample size, the lack of a long-term follow-up related problems.
and the inclusion of highly educated patients with mainly high Methods.– 24 women were studied, all of whom suffer from
comorbid GAD and depression. epilepsy, are between the ages of 25–35, and have one or more
Conclusions.– Group psychoeducation improves RNT and quality of children aged 0–10 years. The “Parental Attitude Research Instru-
life of patients with MDD and GAD. Improvements remain stable ment (PARI)” by E.S. Shefer, R.K. Bell (1958) was used for studying
until 9 months after treatment. the sphere of motherhood.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Based on the results achieved using the PARI method,
interest statement. mothers suffering from epilepsy show the following particular-
ities, as compared to relatively healthy mothers: limited family
interests, family conflicts, the super authority of parents, the
E-PV0025 non-participation of the husband, partner relations, the child’s
Somatization disorder - a frequent active development, over care, equalizing relationships, anxiety,
association with school phobia in avoiding contact, suppressing of will, exclusion extra familial
children and adolescents influences, suppression of aggression, suppression of sexuality,
M.M. Leti1 , R. Grozavescu2 , M. Hăt, is1* , I. Moraru1 , A. Popa1 , A. over-intervention in child’s life. It is possible that the style of
Anton1 upbringing has a directive character and that women are fixated on
1 “Prof. Dr. Alexandru Obregia” Psychiatric Hospital- Bucharest, Child their own children. The patients feel tired from the role of mother,
and Adolescent Psychiatry, Bucharest, Romania; 2 “Prof. Dr. however they strive to devote much time to inner familial interac-
Alexandru Obregia” Psychiatric Hospital- University of Medicine tion, as well as to control and suppress everything that is happening
“Carol Davila”- Bucharest, Child and Adolescent Psychiatry, with the child.
Bucharest, Romania Conclusions.– Therefore, the nature of upbringing among such
* Corresponding author. patients has an authoritarian and directive style. Women with
epilepsy are tired of the role of mother, however they strive to
Background and aims.– In the literature there are several studies that devote a lot of time to interaction with their child.
indicate a frequent association among children and adolescents Disclosure of interest.– The authors have not supplied a conflict of
between school phobia and somatization disorder [1]. Comorbidity interest statement.
is more common in patients with a history of chronic illness, includ-
ing allergies, asthma, recurrent migraines. Unfortunately, this type
of patients have multiple presentations in pediatric services, where E-PV0027
all paraclinical diagnostic methods are depleted, without a favor- Psychopathological and
able result. Thus, the addressability to pediatric psychiatry and the
sociodemographic risk factor for
correct diagnosis are delayed [2].
[1] Inglés et. all (2015). Current status of research on school refusal. persistent somatoform pain disorder
[2] Malas, N.et. all (2017) Pediatric Somatic Symptom Disorders. T. López-Arteaga1* , P. Padilla-Romero2 , C. Romero-Martin3 , J.M.
Methods.– In this context, we present three clinical cases admit- Gallego-Bellido4 , C. Moreno-Rubio2
1 Psychiatrist, Department of Psychiatry- Hospital Ntra. Sra. del
ted in the Child and Adolescent Clinic from “Prof. Dr. Alexandru
Obregia” Psychiatric Hospital, Bucharest. Prado, Talavera de la Reina TO- C.P. 45600, Spain; 2 Hospital Ntra.
Results.– After applying the specific tests (projective tests, assess- Sra. del Prado, Psychiatry, Talavera de la Reina, Spain; 3 Hospital
ment scales, the genogram) and finding the history of the disease, Ntra. Sra. del Prado, Hospital Pharmacy, Talavera de la Reina, Spain; 4
the patients were diagnosed and included in a suitable therapeu- Hospital Ntra. Sra. Del Prado, Unit Addictive Behaviors, Talavera de la
tic program. The evolution was favorable, so the children resumed Reina, Spain
their school activity and learned how to manage their phobia.
Conclusions.– There is a need for awareness programs among pedi-
Background and aims.– The best-suited approach of persistent
atricians and general practitioners about the frequent association
somatoform pain disorder (DSM-5 300.82) (PSPD) is stepped care
between child and adolescent somatization disorder and school
with cooperation operating on the basis of a biopsychosocial model
phobia. Patients should be guided as early as possible to pedi-
of integrating somatic as well as psychosocial determinants of dis-
atric psychiatric services to avoid unnecessary admissions in other
tress and therapeutic factors.
pediatric services, the increase of parental frustration due to the
Objetives.– Determine the psychopathologic and socio-
uncertainty of diagnosis, taking into consideration that these delays
demographic risk factor for PSPD in our area and determine
in diagnosis and intervention may cause worsening of symptoms.
percentage of patients have it associated to chronic non cancer
pain (CNCP).
interest statement.
Methods.– Prospective descriptive study. Sample: 187 patients
evaluated by the department of Psychiatry in the year 2017 derived
from Pain Unit (PU) for psychopathological assessment. Inclusion
E-PV0026
criteria: patients with CNCP and poor response to treatment and/or
The particularities of motherhood for torpid evolution. Exclusion criteria: <18 years old.
women suffering from epilepsy Results.– Patients with PSPD 51%.
T. Kopystseva Igorevna1 , L. Lipatova2* , V. Titova1 Gender female: OR 8 50 (IC 95%: 4 161-17 36, z stadist: 5 87,
1 St. Petersburg State Pediatric Medical University of the Ministry of p < 0 0001)
Healthcare of the Russian Federation, Child Psychiatry Dept, St. Personal psychiatric history: OR 4 00 (IC 95%: 2 45-7 13, z stadist:
Petersburg, Russia; 2 National Medical Research Centre of Psychiatry 4 704, p < 0 0001)
and Neurology Named After V.M. Bekhterev of Ministry of Health of Family substance abuse history OR 0 32 (IC 95%: 0 184-0 55, z
the Russian Federation, Epilepsy Dept, St. Petersburg, Russia stadist: 4 075, p < 0 0001)
Considering having suffered a traumatic event in the biography OR E-PV0029

3 32 (IC 95%: 1 907-5 78, z stadist: 4 235, p < 0 0001) Evaluation of the effectiveness of
Not being the oldest of the siblings OR 6 92 (IC 95%: 3 54-13 50, z
psychopharmacotherapy and
stadist: 5 668, p < 0 0001)
Fibromyalgia OR 4 00 (IC 95%: 2 24-7 13, z stadist: 4 704,
psychotherapy in the complex
p < 0 0001) treatment of systemic lupus
Conclusions.– Half of patients with chronic non-cancer pain and erythematosus
poor evolution have a pain disorder associated. The risk factors N. Maxamatjanova
for presenting pain disorder according to their statistical weight Tashkent Medical Academy, Department of Psychiatry and Narcology,
are: being a woman, not being the oldest of the siblings, having a Tashkent, Uzbekistan
personal psychiatric history, having fibromyalgia, considering hav- * Corresponding author.
ing suffered a traumatic event in the biography and not having a

psychiatric family history. Background and aims.– Today, psychoemotional disorders in
Disclosure of interest.– The authors have not supplied a conflict of rheumatologic diseases are actual.
interest statement. Purpose was to evaluate the effectiveness of psychotherapy (PT)
and psychopharmacotherapy (PPhT) in the complex treatment of
systemic lupus erythematosus.
E-PV0028 Methods.– The study was performed in 48 patients. Of these, 44
Anxiety disorders in Southern Tunisia: (91.7%) women and 4 males (8.3%). The average age of the subjects
was 32 ± 8.2 years. Patients were divided into 2 groups: 1) Main
prevalence and associated factors group - 25 (52%) patients which treated with PPhT and PT; 2) Con-
M. Ben Jmaa1 , Y. Mejdoub1 , R. Boukhchina2 , L. Ghanmi2 , M.
trol group which separated into two group: A - 12 (25%) patients
Maalej3* , J. Jdidi1 , M. Ben Hmida1 , M. Trigui1 , M. Abbes2 , S. Yaich1 ,
which cured with PPhT and basis therapy; B – 11 (23%) were treat-
L. Zouari3 , J. Damak1 , M. Maalej3
1 Hedi Chaker University Hospital, Department of Community ment limited by basic therapy. For evaluation psycho-emotional
status, anxiety, and depression disorders we used Hospital Anxiety
Medicine, Sfax, Tunisia; 2 Regional Hospital of Gabes, Department of
and Depression Scale (HADS).
Psychiatry, Gabes, Tunisia; 3 Hedi Chaker University Hospital,
Results.– According to the HADS scale, clinical manifestations of
Psychiatry « C » Department, Sfax, Tunisia
* Corresponding author. anxiety-depressive syndrome (16 ± 5 points) in main group were
at 21 patients (84%), at 8 (66.7%) in group 2A and at 7 (63.6%) in
Background and aims.– Anxiety disorders (AD) are the most preva- group 2B. Clinically expressed anxiety (16 ± 4.7 points) and sub-
lent psychiatric disorders and represent an emerging public health clinical depression (9 ± 1.1 points) in main group at 3 (12%), at 3
threat in low income countries such as Tunisia. Our study aimed to (25%) in 2A and 2B 27.3% were observed [r < 0,03]. After treatment,
assess the epidemiology of AD and their associated factors among data were analyzing in 2 months by HADS, showed that psychoe-
psychiatric patients in Southern Tunisia. motional disorders in the main group have changed dramatically
Methods.– We conducted a descriptive cross-sectional study. We 7.5 times. In patients with psychopharmacotherapy in the 2A group
included all patients with AD whose first consultation in the psy- psychoemotional condition was improved 3.5 times. Compare with
chiatric department of Gabes in Southern Tunisia occurred between 2B group - only 1.5 times.
2010 and 2013. We collected data using a pre-established anony- Conclusions.– According the study anxiety-depressive syndrome
mous questionnaire exploring the patient’s data. are widespread among patients with the systemic lupus erythe-
Results.– We registered 147 patients with AD (9.1%) among all matosus, which need complex treatment with Psychotherapy and
patients consulting in our department. The sex ratio was 0.75. The psychopharmacotherapy.
mean age was 32 years (IQR = [22–44 years]). Most of the cases Disclosure of interest.– The authors have not supplied a conflict of
were with low socioeconomic status (81 cases; 55.9%) and high interest statement.
educational attainment (82 cases; 56.6%). Forty seven (32.4%) were
unemployed. Seventeen patients (11.7%) had addictive behaviors.
E-PV0030
Principal reasons for medical consultation were anxiety (n = 59;
40.7%), somatic complaints (n = 31; 21.4%), and sleep disorders Psychological determinants of
(n = 21; 14.5%). The median time from the onset of symptoms psychosomatic disorders in
to consultation was 6 months (IQR = [1–18 months]). AD were gastroenterology
significantly less frequent among elderly (OR = 0.23; p = 0.007), S. Moroz* , V. Semenikhina, I. Makarova, R. Khaitov, N. Turishcheva
unemployed patients (OR = 0.44; p < 0.001) and patients with addic- CI “Dnipropetrovsk Region Clinical Hospital Named after I.I.
tive behaviors (OR = 0.6; p = 0.04). Patients with high educational Mechnikov”, Psychoneurology Department, Dnipro, Ukraine
attainment and medium to high socio-economic status had two * Corresponding author.
times higher risk for AD with respectively (OR = 2.2; p < 0.001) and
(OR = 2.7; p < 0.001). Patients with AD consulted earlier compared Background and aims.– The question of psychological factors of the
to the other psychiatric patients (12.8 monthsVS 24.3 months; risks of development of somatic diseases is a relevant and pressing
p < 0.001). issue.
Conclusions.– In our study, the burden of AD was found to be sig- Despite these, depression and anxiety often remain unrecognised in
nificant. Having high educational attainment or medium to high such patients. We examined 139 patients with peptic ulcer disease.
socio-economic status were predictors of AD, while joblessness, Methods.– To assess the psychological status, we performed a clinic-
addictive behaviours and advanced age were associated with a psychopathological examination, Locus of Control based on J.B.
lower risk of AD. Therefore, it is recommended to design preven- Rotter, the picture-association Method and its Application in a
tive strategies that target these associated factors to minimize the Study of Reactions to Frustration by Rosenzweig.
disease burden. Results.– Depression (33,1%, n = 46) and anxiety (43,9%, n = 61)
Disclosure of interest.– The authors have not supplied a conflict of are the most common psychiatric comorbidity. The results of
interest statement. the picture-association Method and its Application in a Study of
Reactions to Frustration by Rosenzweig revealed the predomi-
nance of extrapunitiveness (58,3%, n = 81) and obstacle-dominance
(46,0%, n = 64). The scores on Rotter’s Internal-External Control
Scale significantly correlated with psychiatric comorbidity disor- Methods.– Virtual reality (VR) is a modern technique that allows
ders. Identified. direct (non-imaginative) exposure of patients with social phobia to
Conclusions.– Psychiatric comorbidity is common in theGastroin- phobic situations. Four patients were exposed to VR session (giving
testinal diseases and psychological phenomena arenonspecific risk a talk in front of an audience) in a pilot study on the feasibility of
factors for development and enhancement of a somaticpathology. VR in the treatment of social phobia.
These results should be taken into account in the therapeuticpro- Results.– The VR exposure to the situation of giving a talk in front of
cess. an audience elicited high levels of anxiety. Thus it was confirmed
Disclosure of interest.– The authors have not supplied a conflict of that this technique allows to induce a social fear in vulnerable peo-
interest statement. ple exposed to VR. The anxiety in this situation was so intense that
2 of 4 persons ended the exposure without any verbal expression.
Two persons reported that anxiety was elicited both by exposure to
E-PV0031 VR as well as the presence of the researcher as a person who could
The impact of sleep disorders on the judge their performance during the task. The patient’s prior knowl-
quality of life of patients with edge of the researcher may have a significant effect on the level of
anxiety. Social phobia patients reported that during the exposure
somatoform disorders
to VR they experienced loss of possibility to observe and control
S. Moroz* , I. Makarova
the communication with the researcher, which was an additional
CI “Dnipropetrovsk Region Clinical Hospital Named after I.I.
source of distress.
Mechnikov”, Psychoneurology Department, Dnipro, Ukraine
* Corresponding author. Conclusions.– VR may be an effective method of exposure to anxi-
ety situations in social phobia. The specific features of this type of
Background and aims.– The impact of sleep disorders on the exposure should be carefully monitored and taken into account in
quality of life of patients with somatoform disorders is often planning of therapy with VR.
underestimated. To assess the insomnia, its connection with soma- Disclosure of interest.– The authors have not supplied a conflict of
tovegetative disorders, contribution to the deterioration of the interest statement.
quality of life in patients with somatoform disorders.
Methods.– 124 (69 women and 55 men) patients diagnosed
with somatoform disorders were examined. The average age is E-PV0033
52.16 ± 0.3 years. Questioning conducted using the scale PSQA Reactive avoidance due to negative
(Pittsburgh Sleep Quality Assessment), Epworth Sleepiness Scales, affect in state anxiety among students
The Short Form (36) Health Survey were applied. preparing for job recruitment
Results.– We have determined that Violations of falling asleep were S. Parameswaran* , V. Balasubramanian
observed in 34% of patients, awakening with sleep fragmentation Indian Institute of Technology Madras, Engineering Design, Chennai,
in 86%, early morning awakenings in 48% of patients. Greater fre- India
quency of sleep disturbances, nighttime awakenings, unpleasant * Corresponding author.
dreams were noted in women. There is a tendency to the pro-
gression of manifestations of insomnia as the somatoform disorder Background and aims.–
increases. Clarified the impact of insomnia manifestations on the Introduction.– Reactive avoidance and negative affect in trait anxi-
quality of life parameters. ety are well studied in the literature. Fear among the other negative
Conclusions.– Sleep disorders occur in most patients with somato- affects has mediated avoidance of stressor in people with trait anx-
form disorders, worsening the quality of life of patients. Given the iety.
heterogenety of sleep disorders, a differentiated approach to ther- Objective.– State anxiety being relatively recurrent, the current
apy is required, taking into account the nature of the dissomnic work has been designed to assess reactive avoidance due to the
disorders and the leading pathophysiological factors. affect state of subjects.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– 20 subjects (10 male & 10 female) with mean age 21, who
interest statement. are students preparing for job recruitment participated in the study.
The subjects took a 20 minute general aptitude test consisting of 20
questions. An additional 10 minute test was given to the subjects
E-PV0032 on choice. The Positive and Negative Affect Schedule (PANAS) was
Practical observations on virtual administered before and after the experiment.
reality (VR) exposure in the treatment Results.– The timed aptitude test serves as the source of state anx-
iety. The choice of taking the additional test acts as the test for
of social phobia
reactive avoidance. PANAS scores were compared between sub-
S. Murawiec1* , P. Mierzejewski2 , T. Parnowski3 , P. Bienkowski4 , K.
jects who took the additional test and subjects who chose not to. It
Hanusz5 , D. Draczynska6
1 Scientific Association of Psychodynamic Psychotherapy, Tomorrow was found that negative affect scores were higher in subjects, who
chose not to take the additional test, than in subjects who chose to.
Ltd., Warsaw, Poland; 2 Institute of Psychiatry and Neurology-
Among the negative affects, “afraid” was scored the highest while
Tomorrow Ltd, Department of Pharmacology, Warsaw, Poland; 3
“determined” and “interested” were scored the highest in positive
Polish Geriatric Psychiatry Association, Polish Language Council of
affects.
Polish Academy of Science, Warsaw, Poland; 4 Warsaw Medical
Conclusions.– The results of the work suggest that negative affect
University, Department of Psychiatry, Warsaw, Poland; 5 Tomorrow
of facing the stressor mediates reactive avoidance in state anxiety.
Ltd., R&D Department, Warsaw, Poland; 6 Tomorrow Ltd., PM
Fear, scoring the highest, could be the causal factor for the reactive
Director, Warsaw, Poland
* Corresponding author. avoidance as already shown in trait anxiety.
Background and aims.– Social phobia occurs with a lifetime preva- interest statement.
lence of 2–5% in adults and is a serious mental health problem
limiting daily life functioning of affected patients.
E-PV0034 rience were considered as well. Intensity of baseline symptoms and

Dynamics of level of prolactin in the treatment response were not directly related. Regarding lack of
course of psychopharmacotherapy of response or intolerance, second-line pharmacological treatments
were:
panic disorder - Benzodiazepines: with or without SSRIS / IRSNS combined.
T. Pavlova1* , I. Dorovskih Vladimirovich1 , L. Gorobets Nikolaevna2
1
- Antipsychotics: Quetiapine.
FSCI “1586 Military Clinical Hospital’ of the Ministry of Defence of
- Other antidepressant: Vortioxetine, Bupropion, Vilazidone.
the Russian Federation, Psychiatric Department, Podolsk, Russia; 2
- Pregabaline is more likely to be chosen rather than Gabapentine
FSBI “V. Serbsky Federal Medical Research Centre for Psychiatry and
as a second line of treatment.
Narcology” of the Ministry of Health of the Russian Federation,
- Upcoming therapies: Chamomile and Cannabidiol derivatives.
Department of Psychoendocrinology, Moscow, Russia
CBT appears as the ultimate cost effective therapy. Furthermore,
CBT lasts over time more than drugs, being the most preferable
Background and aims.– In a number of researches at patients choice.
with panic disorder of average, and serious expression high basal Conclusions.– We evidenced a global lack of consensus in the treat-
secretion of prolactin in comparison with healthy participants is ment of AD. The role of the Psychiatrist and the screening of
established. comorbidities is relevant to assess an adequate clinical response.
Aims.– Assessment of initial level of prolactin and its loudspeaker Long-term independent studies with a more representative sample
at patients with panic disorder in the course of monotherapy are needed to improve the outcomes in the treatment of AD.
by antidepressants in comparison with the combined therapy by Disclosure of interest.– The authors have not supplied a conflict of
antidepressants and typical antipsychotic. interest statement.
Methods.– We examined 65 patients with the diagnosis panic dis-
order who don’t have endocrine disturbances which were divided
E-PV0036
into three therapeutic groups:
1. Periciazine and paroxetine therapy The prevalence of migraine in anxiety
2. Clomipramine therapy disorder: clinical study
3. Paroxetine therapy S. Seghaier1* , C. Ben Cheikh1 , M. Lebdi2
1 Military Hospital of Tunis, Psychiatry, Tunis, Tunisia; 2 Militay
The research of initial level of prolactin and in 6 weeks from the
beginning of therapy is conducted. Hospital of Tunis, Psychiatry, Tunis, Tunisia
Results.– 40% of patients had an initial level of prolactin above refer-
ensny values from 1 group, 59% from 2 groups and 47,8% of patients
from 3 groups. In 6 weeks from the beginning of therapy at 75% Background and aims.– This research aimed to study the prevalence
of patients of 1 group the increased Prolactin level is registered, of migraine in patients followed for anxiety disorders diagnosed
and the statistical tendency in comparison with 2 (p = 0,0067) and according to DSM 5 criteria to better understand the relationship
3 (p = 0,0053) groups is taped. In other two groups the percent of between these two commonly associated pathologies.
patients with the increased prolactin level decreased to 50% in 1 Methods.– This is a retrospective study including patients followed
group and 39,1% in the 2nd group. for anxiety disorders diagnosed between January and July 2018 in
Conclusions.– Prolactin level augmentation is characteristic of our psychiatric department. The diagnosis of migraine has been
patients with panic disorder, and monotherapy by antidepres- established according to the criteria of the International Headache
sants leads to its decrease. At the combined therapy by a typical Society (IHS).
antipsychotic and an antidepressant the level of prolactin opposite Results.– 90 patients were admitted in this study, all followed for
increases that it is possible to explain with the hyperprolactinemia anxiety disorders. 47.8% of patients have comorbidity anxiety dis-
bound to action of typical antipsychotic. orders and migraine. The average age is 38.4 ± 10.6 and 2/3 were
Disclosure of interest.– The authors have not supplied a conflict of women. 46.7% of our population had generalized anxiety, 21.1%
interest statement. were followed for panic disorders, 18.9% for agoraphobia and 12.2%
for specific phobias. In the treatment of migraine Nocertone is
used in 39.5% (n = 17), followed by tricyclic (9.3%), ergot deriva-
E-PV0035 tives (7%) and betablockers (4.6%). The prevalence of migraine with
aura is 14% equally distributed between the two sexes. Coordina-
Anxiety, looking forward. state of the
tion between psychiatrists and neurologists was ensured in 40%
art of patients. The pharmacological treatment of the anxiety disorder
V. Rosello Molina* , M. Simon Blanes, C. Ribera, E. Moreno Soldado, was in 30% of fluoxetine, 40% of paroxetine, 25% of venlafaxine and
J. Tejera 5% other molecules. Cognitive behavioural and cognitive therapy
Hospital Universitario La Ribera, Psiquiatría, Valencia, Spain with relaxation was mandatory in migraine patients for the control
of comorbidity.
Background and aims.– Anxiety Disorders (AD) (DSM-V) are a group Conclusions.– A comorbidity between anxiety disorder and
of prevalent disorders affecting globally around 5% of the popula- migraine has been proven in the literature and is supported by the
tion. In US and Western Europe, its incidence is higher reaching 4% results of our study. Further studies to establish the causal relation-
of adult population, with increasing annual costs. ship are needed to better understand the probably bidirectional
The aim of this study was to assess the current situation and per- relationship between them.
spectives concerning the treatment of AD worldwide. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– We reviewed the existing literature in Pubmed Database, interest statement.
MESH terms “Anxiety Disorders”/“Drug Therapy”, English and
including humans, during the last 5 years, RCT, Meta-analysis and
E-PV0037
Systematic Reviews were evaluated. Obsessive Compulsive Disor-
der and not anxiety related disorders were excluded. Anxiety in somatic clinics
Results.– The recommended first-line pharmacological treatments A. Todorov1* , P. Chumpalova1 , M. Stoimenova1 , I. Veleva1 , L.
were SSRIS and IRSNS, with no significant differences. Previous Tumbev1 , G. Georgiev1 , D. Todorieva2 , P. Vladova3 , E. Dimitrova4
1 Medical University - Pleven, Psychiatry and Medical Psychology,
patient response, patient treatment preferences and clinical expe-
Pleven, Bulgaria; 2 Medical University - Pleven, Nephrology-
Haematology and Gastroenteology, Pleven, Bulgaria; 3 Medical Conclusions.– The complex interaction between one’s physical
University - Pleven, Surgical Propaedeutics, Pleven, Bulgaria; 4 symptoms, mental psyche and social circumstances needs to be
UMHAT “D-r Georgi Stranski”, First Psychiatry Cinic, Pleven, Bulgaria evaluated and appreciated in great depth, to develop effective treat-
* Corresponding author. ment strategies for Somatoform Disorders. There is a scope for
further research in this area of medicine.
Background and aims.– Anxiety is a psychological term to define an Disclosure of interest.– The authors have not supplied a conflict of
emotional state, characterized by an insecure feeling and worry. interest statement.
Anxiety appears and increases, regardless of local environment
changes. It is one of the mechanisms for the organism to point out
the necessity for reaction preparation, when a situation changes E-PV0039
and extreme physical and psychological tension is present, the so- Cognitive behavioral therapy in social
called normal anxiety. It is connected to past or present experience
anxiety disorder- a case series
and is formed by one’s view and unconscious internal conflicts;
O. Vasiliu
stereotyped and repeated. “ Dr. Carol Davila” University Central Military Hospital, Psychiatry,
Aim.– To investigate and compare level of anxiety in patients in
Bucharest, Romania
surgical department and oncohematology department. * Corresponding author.
Methods.– We investigated 100 patients – 50 from general surgery
clinic and 50 from oncohematology clinic. For assessment of anxiety Background and aims.– Cognitive behavioral therapy (CBT) is con-
we use The State-Trait Anxiety Inventory (STAI) to assess both state sidered one of the most evidence-based treatments for improving
and trait anxiety. SAD patients clinical status and overall functionality.
Results.– During the first day of hospitalization all patients showed Methods.– Three patients diagnosed with SAD according to the
increased level of situational and other types of anxiety. At the DSM-5 criteria have been included in an individual CBT programme
end of in-patient time situational anxiety level decreased signif- focused on cognitive restructuring and imaginative exposure train-
icantly. Most of the surgery patients reduced their level of anxiety. ing.
On the other hand, we noticed decrease in anxiety among onco- Results.– The first patient was a female, age 35, without psy-
hematological patients, but the level remained higher than those chiatric or somatic co-morbidity, which responded well after 3
in surgery patients. About 20% of the patients were found to have months of weekly CBT sessions, but relapsed soon and needed a
extremely higher anxiety levels – situational and other types. They new course of 12-week sessions. The main trigger of relapse was
were referred for further psychiatrist consults. found in her familial environment, where the relationship with
Conclusions.– Anxiety is an important symptom that is commonly her husband was dysfunctional, and family therapy sessions were
found in somatic clinics. Bound to the fear, unknown and unex- recommended. The second patient was 24-year old, unemployed,
plained, of a serious somatic problem, it could turn into an anxiety severely impaired by SAD, and the CBT was combined with flu-
disorder. oxetine 40 mg daily. He responded relatively well in therapy, the
Disclosure of interest.– The authors have not supplied a conflict of Liebowitz Social Anxiety Scale (LSAS) “anxiety/fear” decreased with
interest statement. 50% and “avoidance” with 40% after 16 weeks, but avoidant per-
sonality features slowed the evolution toward recovery. The third
patient, a 21-year old female student, was also diagnosed with alco-
E-PV0038 hol and marijuana use disorder, which necessitated a more complex
A curious case of an oscillating boy CBT approach, with techniques focused on both social avoidance
S.D. Vanniasingham1* , J. Ng2 and drug craving. Her evolution was oscillating and she discontin-
1 Institute of Mental Health, Department of Psychosis, Singapore, ued therapy after 10 weeks.
Singapore; 2 Institute of Mental Health, Department of Conclusions.– CBT could improve SAD symptoms, but the response
Developmental Psychiatry, Singapore, Singapore may be delayed by comorbid personality disorders, drug use,
depressive and anxiety disorders, various psychological and social
factors with negative impact (e.g. familial relationships, burn-out,
Background and aims.– The patient is a 23 year old male who had
reduced self esteem, lack of therapeutic adherence).
just enlisted into the army 2 months prior to presenting to men-
tal health services. He reported experiencing vertiginous giddiness
interest statement.
episodes for 5 years, associated with a sensation of disequilib-
rium. He also had a 4 months history of involuntary movements
of his body, rocking side to side in an oscillatory fashion. He
had difficulty functioning at home and in camp. This resulted in E-Poster Viewing - 7–9 April: Bipolar Disorders
depressed mood, low self-esteem and suicidal ideation. His Neu-
rologist opined that this was a case of “Hysterical Vertigo”, the
differential being Mal De Debarquement Syndrome. His Otolaryn-
E-PV0040
gologist believed that his clinical presentation was on the spectrum
of Persistent Postural Perceptual Dizziness. A psychiatric diagnos- Evaluation of clinical features
tic dilemma ensued and differentials such as Conversion Disorder between bipolar patients remitted
and Factitious Disorder were considered. The aim was to treat with mood stabilizer monotherapy or
his co-morbid mood symptoms and restore his functioning in antipsychotic combination
society. K. Altinbas* , B. Sen
Methods.– A review of the existing literature on somatoform dis- Selcuk University Faculty of Medicine, Psychiatry- Mazhar Osman
orders and perusal of the patient’s clinical notes was carried out. Mood Clinic, Konya, Turkey
Liaison with his primary treating Psychiatrist, Psychologist, Neu- * Corresponding author.
rologist and Otolaryngologist took place.
Results.– Clinical impression was Conversion Disorder. He was on Background and aims.– Bipolar disorder (BD) is a chronic mood
anti-depressant medication and received regular psychology ther- disorder with recurrent mood episodes and remission periods
apy sessions. With resolution of his stressors, there was good between acute episodes. Morbidity and general functioning of
improvement in his symptoms, mood and functioning. the patients are strongly associated with effective long-term
treatment. Therefore, we aim to compare the demographic and (ˇ = 0.141, p = 0.040) significantly predicted a higher number of
clinical characteristics of bipolar patients on single/dual mood MetS risk factors. The multiple linear regression model explained
stabilizer (MS) and/or mood stabilizer plus antipsychotic (MS + AP) 20.6% of the variance (F = 7.656, p < 0.001).
treatment. Older age (OR = 1.035) and low PLR ratio (OR = 0.988) were
Methods.– Remitted bipolar patients (n = 100) who are followed in associated to a greater likelihood of presenting a MetS (2
Mazhar Osman Mood Clinic of Selcuk University Medical Faculty (6, N = 194) = 17.541, p = 0.007). The logistic regression model
were recruited for the study. Demographic and clinical features of explained between 8.6% (Cox and Snell R square) and 12.6%
patients on single/dual MS and MS plus antipsychotic (AP) treat- (Nagelkerke R squared) of the variance, and correctly classified
ment were compared. 72.2% of the individuals.
Results.– There was no significant difference between groups in Conclusions.– We propose that monitoring PLR and NLR ratios in
terms of gender (p: 0.75, x2 : 0.11), family history of illness (p: 0.69, patients with bipolar disorder may help to identify those patients
x2 :1.44), age (p: 0.94, z: 0.08), education (p:0.08, z: −1.72), age at with a higher risk of presenting the MetS, who might benefit from
onset (p: 0.74, z: 0.33), total number of hospitalization and mood healthy lifestyle counselling and early intervention.
episodes (p: 0.62, z: 0.49; p: 0.93, z: 0.08) and duration of illness Study supported by grant PI11/02493.
(p: 0.82, z: 0.22). However, the rate of psychosis in the first episode Disclosure of interest.– The authors have not supplied a conflict of
was significantly higher in MS + AP group than MS group (p: 0.02, x2 : interest statement.
0.93). Total number of mania and proportion of manic first episode
were significantly higher in the MS + AP group while proportion of
depressive first episode was higher in MS group (p: 0.02, x2 : 5.35). E-PV0042
Conclusions.– Preference of antipsychotics for long-term treatment The psychosocial adaptation and
is consistent with the literature that psychotic bipolar patients quality of life in patients with bipolar
were more difficult to treat. In Turkey, only quetiapine is avail- disorder I type in remission
able among approved treatment options for bipolar depression. Y. Ashenbrenner1,2* , E. Chumakov1,2 , N. Petrova1
Therefore, clinicians might prefer MS for the patients whose first 1 Saint-Petersburg State University, Department of Psychiatry and
episode is depression which also means that these patients would Addictions, Saint-Petersburg, Russia; 2 Saint-Petersburg Psychiatric
experience more depressive recurrence. Hospital №1 Named after P.P. Kaschenko, Day in-Patient Department,
Disclosure of interest.– The authors have not supplied a conflict of Saint-Petersburg, Russia
Background and aims.– Bipolar disorder (BD) is characterized not

E-PV0041 only by recurrent mood disorders but also by impairment in
Neutrophil-lymphocyte ratio, psychosocial functioning and adaptation, which affects patient’s
quality of life (QOL). Aims: to assess psychosocial adaptation and
platelet-lymphocyte ratio and
QOL in patients with BD I in remission.
C-reactive protein predict metabolic Methods.– The sample included 60 patients with BD I in remis-
syndrome in patients with a bipolar sion (according to the DSM-V criteria), who received outpatient
disorder treatment in 2017-2018. The onset of the disorder – 27.92 ± 4.09
B. Arranz1* , M. Sanchez-Autet2 , G. Safont3 , P. Sierra4 , A. years, the average duration of the disorder – 8.08 ± 4.53 years. We
Garcia-Blanco5 , L. De la Fuente6 , M. Garriga7 , G.P. Maria Paz6 applied a questionnaire to collect sociodemographic characteris-
1 Parc Sanitari Sant Joan de Deu- CIBERSAM, Department of tics. Patient’s QOL was assessed with WHOQOL-100 scale.
Psychiatry, Cornella de Llobregat- Barcelona, Spain; 2 Parc Sanitari Results.– It was revealed that 14 patients were unemployed, of
Sant Joan de Deu- CIBERSAM, Department of Psychiatry, Barcelona, whom 6 people were dismissed from work due to the onset of the
Spain; 3 Hospital Universitari Mutua de Terrassa- Universitat de next episode. Allowance for disability was received by 14 patients
Barcelona- CIBERSAM, Department of Psychiatry, Terrassa- (23.3%), these patients had strong difficulties in implementing
Barcelona, Spain; 4 Health Research Institute La Fe - Valencia, even low-skilled labor (R = −0.413; p = 0.001). Only 55.0% (n = 33)
Department of Psychiatry, Valencia, Spain; 5 Health Research of patients were in serious relationship or married, of those 30.0%
Institute La Fe- Valencia, Department of Psychiatry, Valencia, Spain; 6 rated their relationship as conflict. Patients on disability benefits
University of Oviedo- Mental Health Servives of Principado de were less likely to have a harmonious relationship in the fam-
Asturias SESPA- CIBERSAM, Department of Psychiatry, Oviedo, Spain; ily (R = −0.413; p = 0.001). 31.7% (n = 19) of patients committed a
7 Hospital Clinic de Barcelona- CIBERSAM, Programa de Trastorno suicide in the anamnesis. The average WHOQOL-100 score was
Bipolar, Barcelona, Spain 191.8 ± 17.7 (the moderate QOL level).
* Corresponding author. Conclusions.– Sociodemographic characteristics in the examined
patients indicate a low level of objective indicators of adaptation.
Background and aims.– Neutrophil-lymphocyte ratio (NLR) and Patients with BD I in remission have many adaptation problems
platelet-lymphocyte ratio (PLR) are inexpensive markers of inflam- (high level of disability, violations in the family relationships). It is
mation which seem to be increased in patients with mood necessary to conduct psychoeducational work with patients and
disorders. NLR and PLR are also related to a higher risk of metabolic their relatives, to increase the level of compliance between the
syndrome (MetS), and to cardiovascular (CV) risk factors in the gen- patient and the doctor to more carefully monitoring of the patient’s
eral population, although this relationship has not been studied in condition.
BD. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– Our aim was to determine the association between interest statement.
the inflammatory biomarkers NLR, PLR and C-reactive protein
(CRP) and the metabolic status (number of metabolic risk factors,
presence of MetS, insulin sensitivity: QUICKI index and insulin E-PV0043
resistance: HOMA index, in a sample of 219 outpatients with a bipo- Affects of choline in the treatment of
lar disorder (77 men, 142 women). Linear and logistic regression bipolar disorder
models were used. A. Athar
Results.– Older age (ˇ = 0.290, p < 0.001), low PLR ratio (ˇ = −0.276, Sir Ganga Ram Hospital, Medicine, Lahore, Pakistan
p = 0.001), high NLR ratio (ˇ = 0.234, p = 0.003) and high CRP levels * Corresponding author.
Background and aims.– According to statistical data bipolar dis- Objective.– To describe a clinical case reflecting the diagnostic diffi-
order is not a rare condition. Effective methods of treatment culty of atypical new-onset delirious mania as a debut of late-onset
can help control symptoms. Medication is an integral part bipolar disorder.
of treating bipolar disorder and stabilising moods. Our study Methods.– Qualitative design. A case report study of a 56 year-old
aimed to examine choline augmentation of lithium for bipolar female without psychiatric history is presented and discussed. Psy-
disorder. chopathological data were collected through in-depth interviews.
Methods.– Choline bitartrate was prescribed to 10 patients being She was admitted to an outpatient service with a state of vari-
treated with lithium on out patient basis in Sir Ganga Ram hospital able erratic behavior (hiding the earrings under the bed, disrobing),
Lahore. Proper follow up was maintained. restlessness, hyperactivity with purposeless movements during the
Results.– 8 patients had a significant reduction in manic symptoms, night, mutism or stereotyped speech with repetitive bizarre com-
and 4 patients had a marked reduction in all mood symptoms dur- ments such as claiming to be “under magnetic waves or sleeping”,
ing choline therapy. There was a substantial rise in the basal ganglia thought blocking, insomnia and inconsistent disorientation. These
concentration of choline-containing compounds in patients who symptoms began one week after the hospitalization of her mother
showed response to choline. Choline was well tolerated in all cases. with bipolar disorder.
Conclusions.– Choline, in the presence of lithium, was a safe and Results.– Neuroimaging, urinalysis, encephalopathy, autoimmune
effective treatment. and other laboratory test results were normal. After taking Olan-
Disclosure of interest.– The authors have not supplied a conflict of zapine 15 mg/day for 20 days with poor clinical response, we
interest statement. considered non-malignant delirious mania as a late onset of bipolar
disorder. Treatment was supplemented with lorazepam 4 mg/day
and lithium was added to 800 mg/day. On day 40, the patient
E-PV0044 became stable with improvement of speech and behavior.
Offspring of mothers with bipolar Conclusions.– The prevalence of delirious mania in uncertain.
disorder: systematic review on Antipsychotics and mood stabilizers are useful psychotropic med-
ications.
psychological characteristics
R. Bastos* , L.K.S. Campos, D.B. Faria-Schützer, M.E. Brito, D.A.R.
interest statement.
Silva, A.D.S. Junior, E.R. Turato
State University of Campinas, Laboratory of Clinical-Qualitative
Research LPCQ, Campinas, Brazil E-PV0046
Clinical practice in prescribing
Background and aims.– Bipolar affective disorder (BAD) is a psychi- lithium in Tunisia
atric disorder with high heritability, widely demonstrated. In this I. Ben Abid1* , H. Mammi1 , H. Baccari2
context, the offspring of patients with BAD are interesting ways 1 Mohamed Taher Maamouri University Hospital, Mental Health,
to evaluate the natural history of the disease and its prodromal Nabeul, Tunisia; 2 Mohamed Taher Maamouri University Hospital,
symptoms. Systematic review about psychological characteristics Menatl Health, Nabeul, Tunisia
of these offspring would be a way of knowing the characteristics * Corresponding author.
already described in the literature and analyzing them. This study

aims to identify in the scientific literature the psychological char- Background and aims.– Lithium is recommended as the first-choice
acteristics of the offspring of women with BAD. mood-stabilizer (MS) for maintenance treatment of bipolar disor-
Methods.– A systematic review made from the prior consultation to der.
the databases The Center for Reviews and Dissemination (CRD) and Despite this fact, the use of lithium in mood disorders has been
the Cochrane Database of Systematic Reviews. The study was then shown to be decreasing at the expense of other MS.
recorded in the International Prospective Register of Systematic There are hence substantial differences among guidelines indica-
Review (PROSPERO) under the number CRD42017039010. tions and clinical practice for prescribing and monitoring lithium.
Results.– We found 10 articles that suggest vulnerability factors in The aim of this study is to investigate the determinants of lithium
the offspring of mothers with BD; high rates of axis 1 psychiatric prescription.
disorders; as well as behavioral and temperament problems. Methods.– This study was performed over the course of 4 months
Conclusions.– There is a complex family context to which the off- among psychiatrists.
spring of mothers with BD that expose psychosocial difficulties and An anonymous self-report survey was conducted among health
losses in their lives are exposed. This context indicates the need for care professionals prescribing lithium.
family interventions, including early interventions. The items were grouped in different sections ranging from prescrip-
Disclosure of interest.– The authors have not supplied a conflict of tion pattern to therapeutic drug monitoring. Other items explore
interest statement. the perception of the prescriber toward patients and treatments in
bipolar disorders.
Results.– A preliminary analysis of the very first data collected
E-PV0045 suggested that overall knowledge about lithium prescription and
Delirious mania: a debut of late-onset monitoring were satisfying, even though still need to be improved.
Lithium is mostly used as second-line treatment and is still being
bipolar disorder
perceived as a toxic medication. Patients are most of the time con-
H. Becerra Darriba
sidered as not being good candidates for a lithium therapy.
USM Hospital de Alcañiz, Psychiatry, Alcañiz, Spain
* Corresponding author. In this study, we assessed the attitude of psychiatrists toward
lithium prescription but not their behavior. A “know-do” gap has
Background and aims.– Bipolar Disorder is a chronic disease char- not been explored.
acterized by cycling episodes of (hypo)mania and depression, with Conclusions.– Tunisian psychiatrists’ knowledge and perception of
or without psychotic features. About 10% of patients are reported lithium are the most important determinants of its prescription.
to have a late-onset of illness after age 50. Developing a first manic Further studies are needed to investigate the differences between
episode as a delirious mania in the fifth decade of life is considered psychiatrist’s’ knowledge and their real clinical practice. Hence, the
a rare clinical presentation. general refrain from lithium could be adressed.
Disclosure of interest.– The authors have not supplied a conflict of thyroid disturbances. As a result, the earlier the age of initiation of
interest statement. lithium therapy, the greater the risk of developing dysthyroidism.
The study of the duration of treatment and of lithemia as risk fac-
tors showed the absence of significant correlations between these
E-PV0047 factors and the dysthyroids. Regular monitoring of the thyroid is
Therapeutic actualities in the necessary because if hypothyroidism occurs and is untreated, it
management of bipolar disorder in may result in resistance to treatment and worsen the prognosis
the depressive phase of the disease.
M. Bitar1* , L. Achour Achour2 , F. Laboudi Laboudi2 , A. Ouanass Conclusions.– We recommend these patients should be made aware
Ouanass2 of the need for regular monitoring of their treatment and com-
1 Dr, Hopital Arrazi, Rabat, Morocco; 2 Arrazi, Emergency, Rabat, pliance with thyroid control and avoid as far as possible the
Morocco introduction of lithium-therapy at an advanced age.
interest statement.
Background and aims.– Bipolar depression, still poorly understood,
represents 30 to 50% of depressed patients and is the main source
of morbidity in bipolar disorder. The current therapeutic modal- E-PV0049
ities proposed in the management of this depressive phase are in The association between bipolar
perpetual controversy so various algorithms are regularly proposed
affective disorder and multiple
and new molecules are tested. Thymoregulators are currently rec-
ommended in first intention however the place of antipsychotics sclerosis
and antidepressants remains unclear. M. Chakroun* , O. Hdiji, S. Sakka, N. Farhat, H. Haj Kacem, M.
The objective of our study is to update the different modes of man- Dammak, C. Mhiri
agement of bipolar disorder in the depressive phase. Habib Bourguiba University Hospital, Department of Neurology, Sfax,
Methods.– This is a descriptive study carried out on medical files Tunisia
aimed at describing how to treat patients who are consultants or
hospitalized at Ar-razi de Salé hospital with bipolar disorder in the
Background and aims.– Emotional disturbances are highly preva-
depressive phase. This is done using a heterogeneous questionnaire
lent with an early onset in patients with multiple sclerosis (MS)
that surveys the different data and assesses therapeutic attitudes
The presence of psychiatric symptoms in MS was underlined and
in the management of bipolar disorder in the depressive phase.
systematically described as early as in 1877 by Charcot. Many of
Results.– In our sample of 45 patients, the average age is 34.6 years.
these symptoms are described and are not necessarily related to
An age range between 18 and 63 years old. All our patients are
the psychological impact of such a chronic and disabling disease.
under a combination of antipsychotics and mood stabilizers.
Aims.– To discuss the possible etiological hypothesis and treatment
44.4% of our patients were placed on sodium valproate and 28.9% on
options for patients with MS and bipolar disorder.
lamotrigine, 15.6% on carbamazepine and 11.1% on lithium.51.1%
Methods.– We propose two cases and a review of the literature.
of our patients were on olanzapine and 20% on quetiapine.
Results.–
In our sample, 37 patients (80%) were put on antidepressant.
Case 1: A 40-year-old man, was diagnosed at the age of 19 with
46.7% of our patients were put on Sertraline, 15.6% on Escitalopram,
relapsing remitting MS and he was treated with interferon beta
15.6% on Fluoxetine and 4.4% on Paroxetine.
1-a.3 years later he started developing hypomanic episodes with
Conclusions.– The management of bipolar depressions remains
behavioral disorders (simultaneous with MS exacerbations) falls
complex and a major therapeutic challenge for the practitioner.
under a bipolar II disorder.
Case 2: A 18-year-old woman, followed up since the age of 17
interest statement.
for relapsing remitting MS treated with interferon beta 1-a. One
year later, she presented a severe motor relapse and was treated
E-PV0048 with high doses of methylprednisolone. Ten days later, she pre-
sented a manic episode and the cerebrospinal MRI did not show
Dysthyroidism in bipolar patients
new lesions. The diagnosis of bipolar I disorder was confirmed and
treated with lithium she was treated with atypical antipsychotics (olanzapine).
A. Haouala, S. Abid, I. Chaari* , B. Amamou, A. Mechri, L. Gaha Conclusions.– Bipolar disorder may be overrepresented in multiple
Fattouma Bourguiba University Hospital, Psychiatry, Monastir, sclerosis (MS) patients. Although research in this area is limited,
Tunisia studies assessing the nature of this association have focused on
genetic aspects, adverse reaction to drugs and brain demyelinat-
Background and aims.– Bipolar disorder is the main indication of ing lesions. More studies focusing on this specific relation are still
lithium. In all cases, the adverse effects of lithiotherapy such as necessary to establish definitive conclusions.
disturbances in thyroid functioning should be taken into consider- Disclosure of interest.– The authors have not supplied a conflict of
ation. The objectives of our study are to determine the frequency interest statement.
of dysthyroid diseases in patients under long-term lithiotherapy,
to seek correlations between these dysthyroidism and some char-
acteristics of lithiotherapy, and to develop recommendations for E-PV0050
the monitoring and Practice of lithiotherapy in patients at risk for Diagnostic shift from schizophrenia to
dysthyroidism. bipolar disorder: retrospective chart
Methods.– Retrospective study performed on the records of 60 review
patients attending the psychiatry-department at the Fattouma- A. Chrobak1* , W. Janeczko2 , M. Żmudka3 , D. Storman3 , A.
Bourguiba-hospital in Monastir for bipolar disorders and treated Arciszewska1 , M. Siwek4 , D. Dudek1
long-term by lithium salts (theralite*). 1 Jagiellonian University Medical College, Department of Adult
Results.– A global percentage of hypothyroidism is 39.6%. This is Psychiatry, Krakow, Poland; 2 Jagiellonian University Medical
mainly subclinical hypothyroidism in 31.4% of cases. The study of College, Students’ Scientific Association of Affective Disorders,
the age at onset of lithium-therapy as a risk factor in the dysthyroid Kraków, Poland; 3 Jagiellonian University Medical College, Students’
population showed a significant correlation between this factor and
Scientific Association of Affective Disorders, Krakow, Poland; 4 are necessary, as well as surveillance of early signs and symptoms
Jagiellonian University Medical College, Department of Affective of intoxication (figure 1), especially if there are recent changes in
Disorders, Krakow, Poland dietary habits or in treatment (different dosage or new drugs), due
* Corresponding author. to potential interactions.
Background and aims.– Modern studies undermine Kraepelinian

dichotomous subtyping of psychosis into schizophrenic and affec-
tive ones. The diagnostic shift between those diagnostic entities
is not an unusual phenomenon and clinicians should be aware of
eventuality of the change of it. Our objective is to evaluate the rate
and the clinical characteristic of patients presenting diagnostic shift
from schizophrenia (SZ) to bipolar disorder (BD).
Methods.– A retrospective chart review was performed. 420 charts
of the patients hospitalized with the diagnosis of BD consistent
with ICD-9 or ICD-10 criteria were analysed. The group enrolled
in this study were admitted to the Department of Adult, Child and
Adolescent Psychiatry in Kraków between 1980 and 2012. Data
regarding age at the diagnosis, type of the diseases, number of
affective episodes, and the dominant polarity have been collected. Figure 1. Lithium intoxication
Results.– One of thirteen BD patients (33 out of 420) received ini- Disclosure of interest.– The authors have not supplied a conflict of
tial diagnosis of SZ. Mean time to the diagnostic shift was 7.4 yrs. interest statement.
BD patients which converted from SZ presented higher number of
hospitalizations due to psychotic depressive episodes (p = 0.002),
psychotic manic episodes (p = 0.03), non-psychotic manic episodes E-PV0052
(p = 0.03), and more frequent occurrence of type I of BD (p < 0.001), Diagnosis of posible multiple sclerosis
manic and depressive dominant polarities (p = 0.01) that non- in a patient with bipolar disorder:
converting BD patients. case report
Conclusions.– Diagnostic shift from SZ to BD is not uncommon, and it P. Del Sol* , A. Izquierdo, L. Gayubo
is associated with higher number of psychotic depressive episodes, Hospital Universitario Puerta de Hierro Majadahonda, Psychiatric
psychotic and non-psychotic manic episodes, dominant polarities Acute Hospitalization Unit, Madrid, Spain
and type I BD. * Corresponding author.
interest statement. Background and aims.– The aim of this case is to show the possible
comorbidity between bipolar disease and multiple scerosis.
Methods.– The patient is a 43 years old women who was attended
E-PV0051 at the emergency room due to heavy disorganized behaviour dur-
Handle with caution ing the previous days. She was diagnosed with bipolar disorder
N. De Uribe Viloria* , M. De Lorenzo Calzon, M. Gomez Garcia, E. in 2001 (previously she was diagnosed with brief acute psychotic
Rodriguez Vazquez, C. Capella Meseguer, I. Santos Carrasco, J. episode and dissociative psychosis). She was treated with lithium
Gonçalves Cerejeira, A. Alvarez Astorga, H. De La Red Gallego, A. 1000 mg/day, carbamacepine 1000 mg/day, risperidone 3 mg/day
Alonso Sanchez, A. Rodriguez Campos, G. Medina Ojeda, F. De and clonazepam 2 mg/day. For the 10 past days she barely slept, she
Uribe Ladron de Cegama presented high psychomotor restlessness and pressured speech,
Hospital Clinico Universitario, Psychiatry, Valladolid, Spain and she was fired from her job (pharmacy) because of inappropi-
* Corresponding author. ate behaviour. Risperidone dose was increased to 6 mg without
improvement. During the admission she presented irritability,
Background and aims.– Lithium still is the gold standard in the childish speech and low collaboration which were alternated with
treatment of bipolar disorder. Despite this, its risks and correct polite and gentle behaviour other days. A MRI was made with the
management remain overlooked, leading to treatment failure, result of demyelinating lesions.
pharmacological interactions and thus, potentially preventable Results.– The finding of demyelinating lesions is a typical sign
adverse events. of multiple sclerosis. In this patient who didn’t responded to
Our aim is to better understand the symptoms and management of antipsychotic treatment and who also presented a fluctuating
lithium intoxication. symptomatology it was thought that she might be suffering a neu-
Methods.– We present a 63 year- old patient, with history of ropsychiatric comorbidity so that a MRI test was made.
normotensive hydrocephalus, monoclonal gammopathy, arthro- Conclusions.– More studies are needed to prove the relationship
sis, and bipolar disorder, who was admitted to our Emergency between multiple sclerosis (ME) and bipolar disorder. Cognitive
Service for lumbar pain and march difficulties. He follows treat- impairment can be found in both. It is known that patients diag-
ment with lithium, quetiapine, diazepam, ibuprofen, and, in the last nosed with ME are more likely to present psychiatric symptoms.
week, celecoxib. Physical exam evidences hypertension, restless- Depression is presented in 50% of ME. Also bipolar disorder is twice
ness, sweating, and incoherent language. The EKG shows flattened as common as in the general population.
T, lengthened QT, and nickered QRS in II/III/aVF, and blood analy- Disclosure of interest.– The authors have not supplied a conflict of
sis reveals acute renal failure and lithium levels of 2.9. He required interest statement.
haemodialysis, and suffers the following complications, requiring
specific treatment: pneumonia, hydronephrosis with obstructive
uropathy and delirium. E-PV0053
Results.– Lithium intoxication and secondary hydronephrosis, Catatonia, differential diagnosis. A
metabolic encephalopathy and pneumonia.
Conclusions.– Lithium intoxication is a common, overlooked and
case report
M.G. Eliche* , M. García-Poggio
potentially fatal adverse event of treatment with lithium. Periodic
Resident, Psychiatry, Móstoles, Spain
controls of lithium levels, and renal, cardiac, and thyroid function * Corresponding author.
Background and aims.– Catatonia is a neuropsychiatric syndrome E-PV0055

characterized by, moreover, motor abnormalities that occur in Bipolarity traits among backpackers
association with changes in thought, mood, and vigilance. There are ˛
M. Gasior
many psychiatric disorders as well as to others secondary medical University Clinical Centre in Gdańsk, Psychiatry Department, Gdańsk,
conditions. This way, since the DSM-IV released, a broaden catego- Poland
rization has been made. This article reviews a case carried during * Corresponding author.
the hospitalization of a patient, with psychiatric history of bipo-
lar disorder and intellectual disability, and how it was managed Background and aims.– Introduction: Backpacking is a form of low-
as a consultative psychiatry and the importance of the differential cost, independent travel. Most backpackers are in their 20s (even
diagnosis. though the average age of backpackers has gradually increased over
Methods.– We review recent literature about catatonia and diagno- time, and it is now more common to see people in their 30s, 40s, or
sis, focus on the differential diagnosis. even older, travelling this way). The mean age of onset for bipolar
Results.– Catatonia syndrome carries with psychomotor abnormal- I disorder is 18 years and for bipolar disorder 20 years. Taking into
ities, this immobility and mutism are especially common, although consideration the common opinion about the nature of backpack-
none of which are present in all patients. Most catatonic patients ing (spontaneous, risky, etc.), clinical features of hypomania, and
rapidly respond to low-dose lorazepam. Once acute catatonic above-mentioned age characteristics, it is only natural to wonder
episode has been resolved it is important to focus on other pos- whether the prevalence of mood disorders (specifically: hypomania
sibilities in spite of the presence of a psychiatric disorder. episodes) among backpackers is higher than in the general popu-
Conclusions.– Review literature confirms that it is of great impor- lation.
tance to carry an adequate medical history insomuch as the Objectives.– To establish whether the prevalence of hypomania
differential diagnosis is complex. It can arise from a spectrum of episodes among backpackers exceeds that in general population.
psychiatric and medical etiologies, to make it more complicate. Methods.– Methods: An anonymous online questionnaire consist-
Disclosure of interest.– The authors have not supplied a conflict of ing of 3 parts: 1) 2 introductory questions: a screening question
interest statement. about the participant’s current emotional state and a question
about the person’s typical temperament, both excerpted from the
HCL-32 questionnaire, 2) 32 close-ended questions excerpted from
E-PV0054 the HCL-32 questionnaire, and 3) demographic data and psychiatric
Contribution of basal cortisol assay in history.
the exploration of the acute phase of Results.– Results: A total of 36 people took part in the study. In
29 cases the total score in the second part was 14 or more posi-
bipolar disorder tive (“agree”) answers. Only 2 participants admitted having been
A.S. Ellouze1* , M. Maalej1 , M. Naifar2 , K. Jmal2 , W. Guidara3 , S.
treated for psychiatric disorders and taking medication – mood
Omri1 , M. Maalej1 , F. Ayadi2 , N. Charfi1 , J. Ben Thabet1
1 Hedi Chaker University Hospital, Psychiatry “C” Department, Sfax, stabilizers in both cases, combined with antidepressants in one
case.
Tunisia; 2 Habib Bourguiba University Hospital, Biochemistry
Conclusions.– Conclusions: The results suggest a correlation
Laboratory, Sfax, Tunisia; 3 Sfax Medicine School, UR: 12ES17 «
between backpacking and traits of bipolarity. However, further
Molecular Basis of Human Pathology », Sfax, Tunisia
* Corresponding author. investigation is required.
Background and aims.– The diagnosis of bipolar disorder is often interest statement.
delayed because of the absence of specific biological markers. The
role of cortisol in the pathology of this disorder remains controver-
E-PV0056
sial. We aimed to study the role of basal cortisol assay in the acute
phase of bipolar disorder. Vortioxetine for bipolar depression,
Methods.– This was a cross-sectional case-control study conducted effectiveness and safety. A clinical
between June 2016 and July 2018 on antipsychotic-free bipolar experience from a serie of cases
disorder patients compared to healthy controls. Patients were hos- S.P. Gomes Da Costa1* , E. Araúz Cedeño2 , N. Arbelo1 , A. Gimenez1 ,
pitalized at the psychiatric C department in Hedi Chaker University L. Ilzarbe1 , C. Llach1 , P. Bruguera3 , A. Benabarre3 , M. Valentí3
Hospital (UH) in Sfax. The diagnosis of bipolar disorder was estab- 1 Hospital Clinic, Psychiatry - Clinical Institute of Neuroscience,
lished according to DSM-5 criteria. The symptoms’ severity was Barcelona, Spain; 2 National Institute of Mental Health of Panama,
evaluated according to The Bech-Rafaelsen Mania Scale and to the Psychiatry, Panama, Panama; 3 Hospital Clinic, Psychiatry - Bipolar
Montgomery-Asberg Depression Rating Scale. Cognitive functions Disorder Unit - Clinical Institute of Neuroscience, Barcelona, Spain
were evaluated according to the Montreal Cognitive Assessment * Corresponding author.
scale. The analysis of cortisol levels was performed in the laboratory
of Biochemistry in Habib Bourguiba UH in Sfax. Background and aims.– Bipolar Depression remains an unresolved
Results.– This study included 34 patients and 100 male controls. challenge for psychiatric therapeutics. It is associated with signifi-
There was no significant difference between the two groups regard- cant disability and mortality, and represents a major proportion of
ing salivary cortisol and blood cortisol levels. There was a significant follow-up time spent in morbid states despite use of available treat-
and positive correlation between salivary cortisol levels and the ments. Evidence regarding effectiveness of standard treatments,
severity of the manic symptoms. Positive and significant correla- particularly antidepressants, remains limited and inconsistent.
tion was found between blood cortisol levels and the duration of Vortioxetine is a novel antidepressant, acting as a multimodal
untreated bipolar disorder. No significant correlations were found serotoninergic agent with good tolerability. Data on the safety of
between salivary cortisol levels and cognitive functions. vortioxetine for treatment of Bipolar Depression is still lacking. The
Conclusions.– This study allowed better understanding the role of objective of the study is to evaluate the clinical efficacy and safety
basal cortisol assay in the acute phase of bipolar disorder. Further profile of vortioxetine in patients with Bipolar Depression.
research is needed to improve our knowledge about its role in the Methods.– It is an observational, retrospective study. Data collec-
different phases of this disorder. tion was performed after the introduction of vortioxetine as an
Disclosure of interest.– The authors have not supplied a conflict of adjunctive treatment in depressive patients with Bipolar Disorder
interest statement. (BD) I and II (DSM-V criteria), followed at external consulta-
tion. Sociodemographic data, medical history, and clinical and challenge for healthcare professionals, given the increased preva-
psychometric variables were collected. lence of these disorders.
Results.– The sample includes 3 men and 4 women with a mean age To investigate, in people diagnosed with BD, the effectiveness
of 51’7 years old. Four (4) patients were diagnosed with BD I and 3 of standardised educational interventions in enhancing self-
patients with BD II. The introduction of vortioxetine led to a clinical management skills regarding: (i) relapse prevention, (ii) adherence
improvement with a mean reduction in Hamilton Depression Scale to pharmacotherapy, (iii) improvement of quality of life.
of 12,86 points. The prescribed doses ranged between 10 and 25 mg Methods.– Systematic review of available literature on quantita-
with a mean length of treatment of 13,57 months. Only 2 patients tive studies published between 2012 and 2018 in English or Greek
presented mild side effects. languages. Included studies were evaluated for the quality of their
Conclusions.– The use of vortioxetine in patients with BD I and II has methodology with the “Health Evidence-Quality Assessment Tool.
meant a clinical improvement, with a favourable profile of tolera- Results.– Standardised educational interventions were found to be
bility. More studies are needed to evaluate effectiveness and safety associated with: a) early identification of relapse symptoms by the
of this promising antidepressant alternative. patients themselves, b) reduction in the number of relapses, c)
Disclosure of interest.– The authors have not supplied a conflict of reduction in the frequency and length of hospitalization, and d)
interest statement. improved adherence to pharmacotherapy. Moreover, participants
in the studies reviewed reported alleviation of the perceived social
stigma related to mental illness, as well as an improvement in
E-PV0057 their overall functioning and quality of life. No studies were found
Investigation of clinical factors that explore the association between standardised educational pro-
associated with the prediction of grammes and impulse control changes or improvement of cognitive
impairment in people diagnosed with severe mental illness.
manic symptom course in the
Conclusions.– There is evidence that participation in standardised
hospitalized manic subjects with educational programs is associated with a strengthening of dis-
bipolar disorder ease self-management skills in people diagnosed with BD, and
S.W. Hahn an improvement of the overall quality of life. Further studies are
Soonchunhyang University Seoul Hospital, Psychiatry, Seoul, Republic warranted on the effectiveness of training programs in other clini-
of Korea cally relevant disease parameters, such as impulsivity and cognitive
decline.
Background and aims.– This study was aimed to investigate clinical
interest statement.
factors associated with the prediction of clinical course in hospital-
ized patients with bipolar disorder, manic episode.
Methods.– We performed a retrospective observational study based E-PV0059
on the medical records review of 53 bipolar disorder manic
The characteristics of bipolar disorder
patients, who had been hospitalized in the psychiatric ward. Dur-
ing the hospitalization, Young Mania Rating Scales (YMRS) have patients that attended the emergency
been measured periodically. Demographic information and clinical unit of psychiatric service
characteristics including medications and history of prior hospi- T. Jupe* , F. Elezi, E. Myslimi, B. Zenelaj
talization have been collected in each patient. Linear mixed effect UHC “Mother Theresa”, Psychiatry, Tirana, Albania
model has been used to assess the effect of clinical factors on
the changes of YMRS over time. Selection of clinical factors was
conducted using backward elimination with the minimization of Background and aims.– The reason of our study was to describe
Akaike Information Criterion. the characteristics of all patients with Bipolar Disorder appeared
Results.– Mean days of hospitalization were 29.74 ± 16.96. Mean to our emergency, especially demographic and clinical profile and
YMRS at the admission was 33.64 ± 7.57. Effective factors for the the practices among patients treated at the Emergency Unit.
model included YMRS at baseline, combination of mood stabilizer, Methods.– This is a descriptive and quantitative study which social
and the history of prior hospitalization. Predicted YMRS at the dis- demographic data, reasons for attendance, therapy and drug use
charge was 10.43 (95% confidence interval 7.13–13.72). were analyzed.
Conclusions.– The current findings suggest the model which may Results.– Psychiatric staff attended 140 patients over the study
predict the duration of hospitalization of the bipolar disorder manic period. According to our statistics they were: 52% women and the
patients. It would be useful to establish the treatment plan for the average age was 41 years and 35% lived with their family (parents)
patients. and 39% were rural. Actual episode was 48% mix, 16% depressive,
Disclosure of interest.– The authors have not supplied a conflict of 29% maniacal and 7% hypo maniacal, 29% had heredity 1st degree
interest statement. for psychiatric diseases, 39% never got a medicine cure, 7% were
also diabetic, 21% had hypertension, 4% had epilepsy, 14% hepatic
diseases, 6% had cranial traumas.
E-PV0058 Conclusions.– This study emphasizes that it is important for profes-
sionals working in emergency service to have information about
Self-management disease skills in
the patients’ profile and the main reasons that lead them to seek
people with severe neuro-cognitive psychiatric care, and to establish a diagnosis that will allow proper
disorders: a myth or matter of management at the emergency service and case referral.
systematic education? Disclosure of interest.– The authors have not supplied a conflict of
A. Hatzioannou1* , E. Papastayrou1 , A. Chatzittofi2 , S. Sokratous1 , interest statement.
M. Karanikola1
1 Cyprus University of Technology, Nursing Department, Limassol,
Cyprus; 2 University of Cyprus, Medical School, Nicosia, Cyprus E-PV0060

* Corresponding author. Bupropion induced mania: a report of
two cases
Background and aims.– Effective treatment of chronic, severe
E. Kahyacı Kılıç1* , Y. Görgülü2 , R. Köse Çınar3 , M.B. Sönmez3
neuro-biological disturbances, including Bipolar Disorder (BD), is a
1 Uzunköprü State Hospital, Department of Psychiatry, Edirne, sonable alternatives in the treatment of depressive symptoms in
Turkey; 2 Trakya University- School of Medicine-, Department of recent years. Reports of manic switch induction associated with
Psychiatry, Edirne, Turkey; 3 Trakya University- School of Medicine, these medications suggest that infliximab may have an antidepres-
Department of Psychiatry, Edirne, Turkey sant effect.
interest statement.
Background and aims.– Bupropion has been considered to carry
lower risk of switching into mania during bipolar depression treat-
ment when compared to the other antidepressant treatments. We E-PV0062
report two cases of bipolar depression patients that switched to Temperament and character traits in
mania during bupropion treatment as an adjunct to mood stabiliz-
bipolar “I” inpatients with and
ers.
Methods.– without substance abuse
Case 1: A 43-year-old woman with bipolar disorder diagnosis who A. Kheradmand* , Y. semnani
was maintained on lithium and quetiapine presented with depres- Shahid Beheshti Medical University, Psychiatry, Tehran, Iran
sive symptoms. The patient had a manic switch during sertraline
therapy for bipolar depression in the past. it was thought to add
Background and aims.– Bipolar disorder, a serious mental illness,
bupropion XL 300 mg/day to lithium so that the risk of treatment
affect a large number of people. They showed some differences in
emergent mania could be minimized. After about 3 weeks, the
temperament and character traits factors in compared with healthy
patient switched to mania. Her symptoms were controlled with
individual. Moreover, they are prone to substance abuse. The aim
lithium 1200 mg/day and quetiapine 800 mg/day. On the 15th
of this study is comparing Temperament and Character traits in
day of hospitalization, the manic symptoms were reduced signif-
Bipolar “I” inpatients with and without substance abuse
icantly.
Methods.– In this Descriptive Cross-Sectional study the patients
Case 2: A 26-year-old man with bipolar disorder who was
with bipolar I hospitalization in psychiatric ward of Imam Hos-
maintained on lithium and valproate presented with depressive
sein and Taleghani hospitals were recruited. Bipolar disorder was
symptoms. The patient was started bupropion XL 150 mg/day.
diagnosed by SCID. Patients’ temperament and character traits was
After about 4 weeks the patient switched to mania characterized
assessed by Temperament and Character Inventory (TCI) question-
by irritability, grandiose and mystic delusion. His symptoms were
naire.
controlled with lithium 1500 mg/day, valproat 1500 mg/day and
Results.– In this study, 228 patients hospitalized in psychiatric ward
olanzapine 20 mg/day and he achieved euthymia after about 6
with bipolar confirmed diagnosis by SCID were included. Nov-
weeks.
elty seeking showed significantly differences between the groups.
Results.– In both cases bupropion appears to have triggered the
Logistic regression model showed that novelty seeking score can
manic switch and such switching has occurred even in the presence
predict substance abuse in bipolar patients.
of mood stabilizer treatment.
Conclusions.– Our findings indicated that novelty seeking is a major
Conclusions.– Cautious use of bupropion is recommended in bipolar
risk factor for substance abusing in bipolar patients.
disorder patients even though the findings of this two case reports
are not superior to the evidences from larger studies.
interest statement.
interest statement.
E-PV0063
E-PV0061 Prognostic factors in the association
Bipolar disease onset in patients of bipolar disorders and migraine
undergoing immunomodulatory disorders
M. Lebdi* , C. Ben Cheikh, S. Seghaier, F. Ellouze
treatments, a case study Military Hospital Tunis, Psychiatric Service, Tunis, Tunisia
M. Khatib1* , I. Ibañez Plans2 , G. Prat Vigué1 , E. Nieto Rodriguez1 , C. * Corresponding author.
Isern Tena1
1 Mental Health, Psychiatry, Manresa, Spain; 2 Mental Health,
Background and aims.– Bipolar and migraine disorders are both
Psychiatry Child and Adolestent Department, Manresa, Spain serious chronic conditions. Several studies have demonstrated an
association between these two pathologies.
The aim of our work is to highlight prognostic factors in the asso-
Background and aims.– It has been reported that inflammatory path-
ciation of migraine and bipolar disorders.
ways may have an implications in understanding mental illness.
Methods.– It is a study carried out with patients followed at the con-
Reported studies suggest refractive depresion could be treated with
sultation of our psychiatric service of the military hospital of Tunis.
antiinflammatory treatments. In this case report we report onset of
These are patients with bipolar disorder in combination with a
bipolar disease in a 34 year old patient with history of non treated
migraine disorder. The migraine disorder has been evaluated using
ADHD, undergoing immunomodulatory treatment due to severe
the criteria of the International Migraine Society. The bibliographic
spondyloarthropathy.
search was done on PubMed and the data was entered using the
Methods.– Review in recient publications, mesh words used: psy-
Excel software.
chiatry, inflammtion, tnf a antagonist, bipolar switch, resistent
Results.– Twenty-three patients were included in this study all with
depresion.
bipolar disorder and migraine with a sex ratio of 0.94. The average
Results.– Consistent information was found on antidepresant pro-
age was 39 years. 100% of patients had migraine with a migraine
porties of inmunomodulatory treatments, inflammation as part of
background of 5 years. The recurrences of seizures were present in
the physiopatology in depresion.
all patients. In this group of patients 73.9% had a migraine with-
Conclusions.– There are few reports published which to impli-
out aura and 26.08% had a migraine with aura. Out of 18 patients,
cate a TNF-a antagonist in the development of manic switches.
only 11 improved after being treated with tricyclic antidepressant,
Although the role of TNF-a in the pathophysiology of depressive
vasoconstrictor, Nocertone, with an average seizure frequency of
and manic episodes is still unclear, TNF-a antagonists, as well as
2.86 seizures per month.
other immunomodulatory medications, have been studied as rea-
Conclusions.– Migraine and bipolar disorder is an association that Background and aims.– Several studies suggest the involvement of
is most commonly seen in females at a young age. This associa- inflammatory and immunological processes in the pathophysiol-
tion is favorable in migraine without aura. The high prevalence of ogy of psychiatric disorders.
these two disorders is a significant problem and indicates a prior The objective of this work was to study the relevance of the dosage
identification of the risk factors for this combination. of high sensitivity C-reactive protein (hsCRP) in the investigation
Disclosure of interest.– The authors have not supplied a conflict of of bipolar disorders in comparison with control subjects.
interest statement. Methods.– We carried out a case-control study, from June 2016 to
December 2017, at the psychiatry “C” department of Hedi Chaker
University Hospital. Patients with bipolar disorder (BD), who had
E-PV0064 not taken antipsychotic medication for at least three months before
Depot neuroleptics in bipolar disorder admission, were included in the study. The diagnosis of BD was
T. López-Arteaga1* , P. Padilla-Romero2 , C. Romero-Martín3 made according to the DSM-5 criteria. Each of the patients and
1 Psychiatrist, Department of Psychiatry- Hospital Ntra. Sra. del the controls had a clinical examination, an assessment by the posi-
Prado, Talavera de la Reina TO- C.P. 45600, Spain; 2 Hospital Ntra. tive and negative symptoms scale (PANSS) and inflammatory blood
Sra. del Prado, Psychiatry, Talavera de la Reina, Spain; 3 Hospital tests.
Ntra. Sra. del Prado, Hospital Pharmacy, Talavera de la Reina, Spain Results.– Thirty two patients and 90 controls were included in the
* Corresponding author. study. The hsCRP level was significantly higher in patients than in
controls (3.28 ± 3.48 mg/L versus 1.82 ± 2.06 mg/L, p = 0.012). The
Background and aims.– inflammatory state was significantly correlated to the PANSS score
• Introduction.– Bipolar disorder (BD) is a complex pathology, of positive symptoms (p = 0.043). Patients whose state required
which not only associates clinical affect, but also psychotic and the association of many psychotropic medications had a hsCRP
high rates of comorbidity. There is not enough evidence in the lit- level on admission significantly higher than those who were
erature about the use of depot in bipolar disorder for both acute treated by a monotherapy (3.32 ± 2.94 mg/L vs 0.65 ± 0.07 mg/L,
and maintenance phases. p = 0.02).
• Objetives.– We assess the effectiveness of paliperidone palmitate Conclusions.– Our results are consistent with the hypothesis of
once monthly (PP1 M) for the psychopathological stabilization of the involvement of inflammation processes in the pathophys-
patients with BD. iology of bipolar disorders and encourage further research on
Methods.– the place of anti-inflammatory drugs in the treatment of bipolar
• Retrospective study of a series of patients with bipolar disorder: disorders.
women aged 24 to 50 years old, admitted to Mental Health Hospi- Disclosure of interest.– The authors have not supplied a conflict of
tal from January to June 2018. Substance use disorder (SUD), both interest statement.
bipolar disorder subtype and patients family psychiatric history
are not factors of exclusion (table 1).
Results.–
Table 1 Retrospective study of a series of patients with bipolar disorder
Age SUD Family Time of disease Last Time for Treatment Criteria for choice
history evolution episode euthymia of treatment
Patient 1 24 yes no 3 years F31.2; F12.20; 8 weeks Valproic 1.500mg/day SUD, without
F61 PP1M 100mg conscience of disease
Patient 2 43 yes yes 10 years F31.4; F13.10; 12 weeks Valproic 1.500mg/day Thoughts ofdeath,
F10.1; F60.3 PP1M 75mg without treatment
adherence
Patient 3 50 no yes 33 years F31.71 4 weeks Valproic 1.500mg/day Side effects to
PP1M 150mg lithium: tremor,
diplopia. Clinical
instability
Conclusions.– The combination of valproic acid and PP1M is effec-

tive in the acute phase of BD. It is useful for long-term adherence
and maintenance, has no side effects such as lithium and achieves
improvement in substance abstinence.
Disclosure of interest.– The authors have not supplied a conflict of E-PV0066
interest statement. Use of hormone replacement therapy
in women with bipolar disorder: a
review
E-PV0065
C. Machado
Relevance of the dosage of high Hospital Magalhães Lemos, Psychiatry, Porto, Portugal
sensitivity C-reactive protein in the * Corresponding author.
investigation of bipolar disorders

Background and aims.– Hormonal fluctuations are associated with
M. Maalej1* , M. Naifar2 , A.S. Ellouze1 , W. Guidara3 , S. Omri1 , M.
an increased risk of affective dysregulation and mood episodes in
Maalej1 , F. Ayadi2 , N. Charfi1 , J. Ben Thabet1
1 Hedi Chaker University Hospital, Psychiatry “C” Department, Sfax, women with bipolar disorder (BD). Examples of this are the high
rate of depression during the postpartum period and the increase
Tunisia; 2 Habib Bourguiba University Hospital, Laboratory of
in mood instability during the menopausal transition, particularly
Biochemistry, Sfax, Tunisia; 3 Sfax Medical School- University of Sfax,
an increase in depression.
Research Unit “Molecular Basis of Human Pathology”, Sfax, Tunisia
The aims of this work are to review the published studies con- Background and aims.– In the bipolar patient, the passage to the act
cerning the use of hormone replacement therapy (HRT) on BD, can be prepared and premeditated, but it can also be impulsive and
specifically, possible indications for its use, the potential adverse brutal, in the form of drive discharge and of psychic economy.
effects and the role of HRT in the prevention of mood episodes. Describe the socio-demographic and clinical characteristics and
Methods.– A search was made on databases Pubmed and Cochrane different impulsiveness scores of bipolar patients with cannabis
Library with the mesh terms: bipolar disorder or mania or bipolar use disorder.
depression and hormone replacement therapy, selecting the arti- Methods.– This is a descriptive cross-sectional and analytical study
cles published between 1994 and 2018. A total of 39 articles were conducted on patients followed for bipolar disorder at Razi La Man-
found and of these 15 selected for this work. nouba hospital.
Results.– Evidence for the role of HRT per se in the treatment The patients recruited had a disorder of Cannabis use according to
of women with BD is limited. Exogenous estrogen has been DSM 5.
linked with the induction of mania and rapid cycling, and con- Impulsivity was evaluated by the BIS 11 scale.
versely an estrogen–progesterone combination showed success Results.– We recruited 19 patients all of them male. The average
for treatment-refractory post-partum mania. The use of HRT in age of the patients was around 34, 11 years old.
perimenopausal and postmenopausal women with BD shows con- Single persons were in the majority with a percentage of 73.7 The
troversial results in the prevention of depression. On the other majority of patients were of urban origin (84.2%).
hand, the diagnosis of BD is not a contraindication to the use of The secondary level was the majority in this group with a percent-
HRT for the relief of menopause symptoms. age of 84.2.
Conclusions.– Throughout the reproductive cycle of bipolar women, The presence of a family history was found in 26.9% of the cases
HRT can be considered for the prevention or treatment of mood whose bipolar disorders represented 40.8% The antecedent of
episodes, although there is a lack of systematic reviews in this area. attempted suicide were reported by 8 patients (42,1%). Thirteen
Disclosure of interest.– The authors have not supplied a conflict of out of nineteen patients had daily cannabis use More than half of
interest statement. these patients consumed more than 4 joints a day Sixteen out of 19
patients (84.2%) had a high level of impulsivity.
No significant relationship was found between impulsivity and
E-PV0067 cannabis use.
The mixed episode: the biggest Conclusions.– Abuse of substance and especially cannabis, although
therapeutic challenge in bipolar it shares a high impulsivity with Bipolar Disorder, could not fully
explain the elevation of the BIS 11 score in patients with this psy-
disorder
chiatric disorder.
F. Medini1* , W. homri2 , R. labbane3
1 Disclosure of interest.– The authors have not supplied a conflict of
Razi Hospital, Razi Hospital, Mannouba, Tunisia; 2 Hospital Razi,
interest statement.
Psychiatry, Mannouba, Tunisia; 3 Razi Hospital, Psychiatry,
Mannouba, Tunisia
E-PV0069
Background and aims.– The goal of our study was to investigate the A case of comorbid posttraumatic
clinical and the prognostic aspects of mixed states according to the stress disorder in bipolar disorder in
polarity of the first episode. military patient
Methods.– We achieved a retrospective descriptive cross-sectional D. Mnif
study on 77 cases of patients with bipolar disorder. Our study was Psychatric Resident, Psychatric Department of Military Hospital of
conducted between September 2004 and September 2013. Tunis, Tunis, Tunisia
Results.– The type of first episode was manic in 59.7% of cases * Corresponding author.
(n = 46), it was a type of depression in 26% of cases (n = 20), and
finally it was mixed type in 14.3% of cases (n = 11). Compared to Background and aims.–
other patients, for those with a manic first episode, polarity at onset Introduction.– Studies provide evidence for elevated rates of post-
is predictive of the dominant polarity of the disorder, the age of traumatic stress disorder (PTSD) in patients with bipolar disorder
onset of the disease was the lowest with an average of 24.6 ± 6.9 (BD). The coexistence of PTSD is a particularly difficult challenge in
years, and the evolutionary history of the disease included more the treatment of BD with antidepressants (AD).
mood episodes. For those with a mixed episode at onset, we noted Aims.– Description of clinical presentation and treatment strategies
a clear female preponderance, in fact, the sex ratio was 0.57. And for a better recovery.
for those with a depressive episode at onset, the evolutionary his- Methods.– A case report of a military patient in treatment for comor-
tory of the disease included a greater frequency of suicide attempts, bid PTSD in BD type 1.
with an average of 0.9 attempts and high prevalence of substance Results.– A 41-year- old patient with a family history of mood disor-
abuse; it was noticed in 70% of cases. der. His mother was treated for bipolar depression. He was initially
Conclusions.– Accurate knowledge on the clinical characteristics treated, at the age of 33, for depression with resistance for differ-
and the evolutionary course of disorder since the first bipolar ent AD (paroxetin, anafranil) and persistant low global functioning .
episode may help clinicians to develop more specific therapeutic He was diagnosed with Comorbid PTSD and substance use disorder
intervention for patients with mixed states. (SUD) after 7 years of treatment. The stressor event happend five
Disclosure of interest.– The authors have not supplied a conflict of years before the first episod. He received then venlafaxine for one
interest statement. year without getting better . He was hopitalized for maniac episod.
We decided to stop AD and to put him under valproate (1500 mg).
We observed improvement in impulsivity and intrusive symptoms
E-PV0068 with mood stabilizer.
Impulsiveness and disorder of Conclusions.– PTSD occurs at elevated rates in patients with BD,
cannabis use in bipolar patients and is associated with a more severe course of disorder. Clinicians
M. Mlika* , A. Bouallagui, O. Moula, A. Ferchichi, R. Ghachem should think about monitoring symptoms of PTSD in patients with
Razi Hospital, Psychiatry, Tunis, Tunisia BD. Some mood stabilizers appear to be effective for the treatment
* Corresponding author. of PTSD.
Disclosure of interest.– The authors have not supplied a conflict of made at least one suicide attempt, and the mean number of suicide
interest statement. attempts was 0.4. During the study, 63.3% were euthymic, 6.7% were
in hypomania and 30% had depressive symptoms. The mean score
of positive religious coping was 23.42 (min = 8, max = 28). Positive
E-PV0070 religious coping strategies were associated with fewer depressives
Bipolar affective disorder in multiple ymptoms (p = 0.01).
sclerosis: a review Conclusions.– Positive religious coping is strongly associated with
R. Mota Freitas* , A. Boavida Guerra fewer depressive symptoms. Religiosity is a relevant aspect of
Espírito Santo Hospital, Department of Psychiatry and Mental Health, patients’ lives and should be taken into consideration by physicians
Évora, Portugal when assessing and managing bipolar disorder patients.
interest statement.
Background and aims.– The presence of psychiatric manifestations
in multiple sclerosis (MS) is well established and they may be the
presenting symptoms of the disease. Bipolar affective disorder (BD) E-PV0072
is estimated to be twice as common in MS as in the general pop- Post stroke mania - a rare
ulation. The effects of steroid treatment alone cannot explain this complication not to forget
association and the link between MS and BD is not fully understood. R. Saraiva1* , F. Proença2 , M.J. Gonçalves1 , A.C. Sereijo1 , R.
In this review, we aimed to summarize the current understand- Barandas1 , R. Coentre1
ing of BD in MS patients and the most recent perspectives in its 1 Hospital Santa Maria Centro Hospitalar Lisboa Norte, Psiquiatria,
management. Lisboa, Portugal; 2 Hospital Santa Maria Centro Hospitalar Lisboa
Methods.– We searched the PubMed database for reviews, system- Norte, Neuroradiologia, Lisboa, Portugal
atic reviews, meta-analyses and case reports on bipolar disorder in * Corresponding author.
multiple sclerosis in humans, published in the last 10 years. Titles
and abstracts were screened for relevance, followed by full-text Background and aims.– Various organic diseases can trigger a manic
review. The search retrieved 65 results. Following title, abstract episode. Stroke is often associated with psychiatric symptoms, par-
and full-text reading, 13 papers were included. ticularly depressive, and more rarely manic.
Results.– Etiopathogenic bases explaining the association between We aim to report a case of recurrent mania after a stroke, in a
BD and MS remain unclear. The effects of corticosteroid therapy patient without previous history of psychiatric illness and to do
and the psychological distress caused by the diagnosis of MS can- a brief review about post stroke mania.
not fully explain it. The role of genetic vulnerability and a common Methods.– Literature review on mania and bipolar disorder after
neurological substrate have been suggested, but evidence to sup- stroke (MEDLINE literature review) and description of the clinical
port these hypotheses is scarce and contradictory. Other factors, case with information provided by the patient or by his medical
such as shared autoimmune and infectious mechanisms are likely records.
involved. Results.– Post stroke mania is rare and reports of the evolution after
Conclusions.– Management of BD in MS is not yet solidly estab- acute phase of the manic episode or reports of recurrence are even
lished. Additional research in this area must be conducted to further rarer. We describe a 67-year-old man with no personal or family
assess the association of BD and MS so that appropriate manage- history of psychiatric illness, with hypertension, dyslipidemia and
ment strategies can be developed. diabetes, who at age 64 had a bilateral ischemic stroke in the mid-
Disclosure of interest.– The authors have not supplied a conflict of dle cerebral artery territory. About twenty days after this stroke
interest statement. he developed a manic episode with hospitalization in a psychiatric
ward. In the following years, he was clinically stable under 1000 mg
sodium valproate per day, being totally independent in the activ-
E-PV0071 ities of daily living. Three years after this episode he developed a
Impact of religious coping in patients new manic episode.
with bipolar disorder Conclusions.– This case shows that it is possible for an organic dis-
N. Sahar* , R. Sellami, F. Cherif, I. Baati, I. Feki, J. Masmoudi ease to cause a syndrome with an evolution overlapping a primary
The University Hospital Hedi Chaker Sfax Tunisia, Psychiatry A, Sfax, psychiatric illness even in individuals without history of psychi-
Tunisia atric disorders. Although rare, the diagnosis of mania after stroke
* Corresponding author. should not be forgotten, and most important, one should be aware
the a recurrence mays occur.
Background and aims.– Religion is an important coping strategy that Disclosure of interest.– The authors have not supplied a conflict of
have been rarely studied within the context of bipolar disorder. interest statement.
The present study aimed to investigate the relationship between
religious coping and clinical characteristics in patients with bipolar
disorder. E-PV0073
Methods.– In a cross-sectional study of bipolar disorder outpatients The longitudinal outcome of bipolar
(N = 30) from the mood consultation of the psychiatric departe- disorder
ment A, we assessed symptoms of mania [Young Mania Rating R. Paunescu, A.C. Serban* , B. Suciu, I. Miclutia
Scale], depression [Beck Depression Inventory], religious coping University of Medicine and Pharmacy Cluj Napoca, Psychiatry, Cluj
(Brief RCOPE). Sociodemographic and clinical data, were obtained Napoca, Romania
through an interview with the individual and analysis of the * Corresponding author.
patient’s medical records.
Results.– In our sample the mean age was 46 ± 11.8 years. The half Background and aims.– Bipolar disorder is a chronic psychiatric ill-
were women. Among our patients, 60% had a religious regular prac- ness with compresses affective episodes of different polarities. Its
tice, 20% had an irregular practice and 20% had no religious practice outcome involves relapses, complete and partial recoveries and
but had a sense of appartenance. Among our patients, 80% were euthymic periods.
followed for a bipolar 1 disorder, 20% for bipolar 2 disorder. The Methods.– We analyzed the medical files of 70 patients diag-
mean number of hospitalizations was 2.63. About the quart have nosed with bipolar disorder for a period of 5 years since the
onset of illness. The aim of the study was to assess the number E-PV0075
of episodes/hospitalizations, types of mood episodes, the pres- Incidence rate of comorbid mental
ence of psychotic features and psychiatric and non psychiatric
disorders in bipolar disorder
comorbities,
S. Vasilieva
Results.– The patients included cumulated a number of 217 hos-
Mental Health Research Institute- Tomsk National Research Medical
pitalizations over the 5 years following the onset of bipolar
Center- Russian Academy of Sciences, Affective States Department,
disorder. Most admissions to the hospital were due to manic
Tomsk, Russia
episodes (55,1%), followed by depressive episodes (37,9%) and * Corresponding author.
episodes with mixed features (7%). The number of hospitaliza-
tions ranged from 1 to 11 for the mentioned time period. The Background and aims.– Epidemiological and clinical studies reveal
mean duration between hospitalizations was 11, 8 months vary- the high level of comorbidity of bipolar disorder (BD) with other
ing from 2,74 to 41,16 months. The mean number of admissions mental disorders (Kessler R. et al., 2005; Moreno C. et al., 2012).
was higher in females patients compared to male patients. Psy- Objective: Evaluation of the incidence rate of comorbidity of BD
chotic symptoms occurred in 24,3% of depressive patients and with other mental disorders.
in 51,2% of manic patients. 32% of the patients had psychiatric Methods.– 101 patients (72 women, 29 men) with verified diagnosis
comorbidite. Medical comorbidities were seen in 43,69% of the of bipolar disorder (BD) were examined. Methods were clinical-
patients. psychopathological, clinical-follow-up, statistical.
Conclusions.– For a five years period from the onset of bipolar dis- Results.– 46 patients (45.5%) along with BD had another mental
order, most patients presented more than one admission to the disorder. At the same time in eight pateints (7.9%) two comor-
hospital. The duration of the hospitalization is correlated with the bid mental disorders and in three persons (3.0%) – three comorbid
severity of the mood episode and the presence of psychotic features. mental disorders were revealed. The spectrum of comorbid men-
Disclosure of interest.– The authors have not supplied a conflict of tal disorders was represented as follows: anxiety disorder – 20/46
interest statement. (43.5%), personality disorder – 19/46 (41.3%), substance depen-
dence syndrome – 13/46 (28.3%), obsessive-compulsive disorder –
2/46 (4.3%). Distribution of BD patients from the main group respec-
E-PV0074 tive from nosology of comorbid disorder is presented in the table.
The effect of psychoeducation on Nosological structure of mental disorders comorbid with BD in
internalized stigma in Iranian patients of the main group Comorbid mental disorder n/N(%) Anxi-
hospitalized patients with bipolar ety spectrum disorders: 20/46(43,5%) -Panic disorder 12/23(51,2%)
-Generalized anxiety disorder 4/23(17,4%) -Mixed anxiety disor-
disorder der 5/23(21,7%) Personality disorder: 19/46 (41,3%) -Hysterical
N. Seyedfatemi1* , Z. Keshvarz1 , M. Mardani Hamooleh1 , H.
personality disorder 4/19(21,1%) -Borderline personality disorder
Haghani2
1 Iran University of Medical Sciences, Psychiatric Nursing, Tehran, 3/19(15,8%) -Mixed personality disorder 12/19(63,2%) Obsessive-
compulsive disorder 2/46 (4,3%) Substance dependence syndrome
Iran; 2 Iran University of Medical Sciences, Biostatistics, Tehran, Iran
* Corresponding author. 13/46 (28,3%).
Conclusions.– Thus, results of our study show that BD is frequently
Background and aims.– accompanied by comorbidity with other mental and behavioral dis-
Background.– Stigma is one of the most common problems in people orders among which anxiety spectrum disorders and personality
with psychiatric disorders. The aim of this study was to investi- disorders predominate.
gate the effect of educational program on the internalized stigma Disclosure of interest.– The authors have not supplied a conflict of
of patients with bipolar disorder. interest statement.
Methods.– This was a pretest-posttest quasi-experimental study
which was performed on 76 patients with bipolar disorder
admitted to the Iranian Psychiatry Center in 2016. Non-random
E-Poster Viewing - 7–9 April: Child and Adolescent
continuous sample was performed considering gender based on the
criteria for entering the study. First, the control group was selected Psychiatry
to prevent data contamination. The pre-test was performed using
an Internalized Stigma of Mental Illness Scale and the post-test was
performed 2 weeks later. Then, the sampling was started for the E-PV0076
experimental group. After the pre-test, the intervention was per- Cognitive deficits and deviance
formed within 2 weeks (3 sessions per week) and after the end of communication in family interactions
the last session, the post-test was performed. Data were analyzed
by SPSS software version 16.
as a risk factor for thought disorders
Results.– Findings showed that there was no statistically sig- and psychotic disorders
nificant difference between two groups before in terms of J. Denis* , A. Namèche
demographic characteristics and total score of stigma. After University of Mons, Psychology, Mons, Belgium
intervention the scores of Alienation, Discrimination Experi-
ence reduced significantly (p < 0.05), Stigma Resistance (p < 0.001)
Background and aims.– Psychotic Disorders (PD) is characterized
and total score of stigma (p < 0.05) in the intervention group
by the presence of cognitive disorders from childhood (Lewis,
compared with the control group, whereas there was no signif-
2004). Among the much studied environmental risk indicators
icant change in the score of Stereotype Endorsement and Social
are parental Communication Deviance (CD) and genetic and
Withdrawal.
environmental risk factors. The presence of thought disorder is con-
Conclusions.– Conclusion: Considering the effect of psychoeduca-
ventionally inferred from disordered speech who is also impaired
tion on a large number of subscales, as well as the total stigma
in PD (DeLisi 2001).
score, stigma education can be used in psychiatric centers.
The aim of our research is to investigate the role of parental CD as a
risk factor for thought disorders and psychotic disorders in children
interest statement.
aged between 4 and 7 years.
Methods.– The association between parental Communication E-PV0078

Deviance scored from family Rorschach protocols and the cogni- Youth suicide attempts and its
tive characteristics of the child were investigated. To this end, the
relationship to alienation - a study on
Wechsler Scale (WPPSI-IV) was used as well as the Thought Disor-
der Index (Johnston & Holzman, 1986) and the ToM emotion tasks
a sample of youth suicide attempts in
(Nader-Grosbois & Thirion-Marissiaux, 2011). Western Algeria -
Results.– The results indicate that the amount of Communication L. Fekih1* , M. Bekhadra2
1 University of Tlemcen, Psychololgy, Tlemcen, Algeria; 2 University of
Deviance is a stable trait of an individual in a family. It may be
considered as a risk indicator for psychotic disorders and also for Tlemcen, Department of Humanities Sciences, Algeria
thought disorders in offspring.
Conclusions.– More researches should be reveal the mechanisms
Background and aims.– Suicide in Algeria is considered as a complex
by which parental CD could affect the growing child’s cognitive
subject issues that still needs research efforts, especially that offi-
development and lead to impairment in cognitive functioning.
cial authorities does not have accurate statistics about suicide. The
The connection between Communication Deviance, thought disor-
aim of the present study was to identify some of the data relating
ders, theory of mind and psychotic disorders should be clarified.
to epidemiologic of suicide among young people, and identify the
It is possible that the link between parental CD and psychotic
various psychological conditions that surround them. The question
disorders in a child is actually a link between CD and thought
that reflects the problematic in this study is: Dose youth tends to
disorders.
suicide for reasons lie in poverty, unemployment, academic and
emotional problems, or for deep psychological reasons that refer
interest statement.
to alienation.
Methods.– To achieve the purpose of this research was chosen
E-PV0077 intended sample selected from hospitals and youth homes contain-
ing 83 young man and women who have already try to suicide in
Adolescence and self-injuries: the west of Algeria, including 30 male and 53 female aged between
characteristics of current society 17 and 30 years old.
Y. Quevedo, S. Viani, A. Dörr* Tools that were used are: Seman’s Alienation Test (revised version
University of Chile, Psychiatric and Mental Health, Santiago, Chile in 2004), and Motivations and Factors for Suicide Checklist.
To analyze data, the researcher used a range of statistical methods
as the medium, standard deviations, percentages, chi-square (O2 ) to
Background and aims.– This research aims to enrich the reflec-
calculate the difference between frequency distributions and t-tests
tion on the current affairs and an invitation to think about
for independent-samples.
worrying phenomena in youngsters: self-injuries or cuts in the
Results.–
arms in eight young adolescent patients. We try to figure out
- The average of alienation among youth suicide attempts was high.
the underlying cause of such behavior, which is more com-
- There is a statistical significant difference (0.01) between the
mon every day and reveals some characteristics of society.
sexes in terms of suicide motives.
Sociocultural, individual and family changes are analyzed, show-
- There is no statistically significant difference between the sexes
ing possible connections among these instances, identity and
in term of manifestations of alienation (isolation, no values; dis-
self-injuries.
ability, no meaningful).
Methods.– Clinical interview and questionnaire:
Conclusions.– The study proposed some recommendation and pre-
With a qualitative methodology, descriptive, exploratory design,
ventive measures to mitigate the impact of suicide attempts
we try to find the constitutive elements of phenomena about the
self-injuries or cuts in the arms in young adolescent patients. Three
interest statement.
levels are analyzed in ten young adolescent to know if there is some
possible connections among these instances and the development
of identity and self-injuries: E-PV0079
• Sociocultural,
• individual Neuropsychiatric disorders in children
• family changes and adolescents with klinefelter
Results.– syndrome (47, XXY) the importance of
The analysis of the questionnaire applied during the clinical inter- social cognition: a case report
view, the results show a possible connection between the three N. Fernández Gómez* , M. Alcamí Pertejo, M.A. Ortiz Villalobos, L.
levels analyzed (sociocultural, individual; family changes) and Mellado Cuerno, V. Romero Pardo, J.M. Pastor Haro, J. Curto
practices such as self-injury, cuts, tattoos, branding and piercing Ramos, M.F. Bravo Ortiz
in different parts of the body. Hospital Universitario La Paz, Psychiatry and Mental Health, Madrid,
Conclusions.– We suggest that the difficulties in identity devel- Spain
opment may be related to practices such as self-injury or others, * Corresponding author.
which are related to mentalization problems. In the sociocultural
level we find a way to socialize in which subjective discom- Background and aims.– Klinefelter syndrome (KS) is a genetic dis-
fort has increased, there is overabundance, mass consumption, order characterized by the presence of an extra X chromosome
and the traditional social institutions (family, school and reli- (47, XXY). Despite of the fact that endocrinologic and physical
gion) have failed. Youngsters do not know themselves nor their features are the most described, KS also involves increased risk
projects of developing psychiatric disorders (autism, schizofrenia, schizoid
Disclosure of interest.– The authors have not supplied a conflict of personality) which are related to social cognition and verbal
interest statement. impairments. Our aim is to describe the clinical case of a 15 years
old boy with KS, behavioural disturbances and poor social interac-
tion. We also aimed to reach a well defined psychiatric diagnosis of
these clinical symptoms.
Methods.– We describe and analyse the clinical case of a 15 years
old boy with KS and behavioural disturbances. Autism Diagnosis
Observation Schedule-2 (ADOS-2) Module 4 was administered and E-PV0081

results of Wechsler Intelligence Scale for Children- Fouth Edition Behavioral and biological implications
(WISC-IV) were included. We also conduct a literature review about
of preterm birth: a mouse-based
the neuropsychiatric disorders in this syndrome.
Results.– WISC-IV score was 100 (average intelligence quotient -IQ-
model
). Impairments in verbal skills were not detected. Resuts of ADOS-2 M. Franko1,2* , G. Ben-David1,2 , R. Doron3,4 , N. Gueron-Sela1,2
1 Ben-Gurion University of the Negev, Dep. Of Psychology, Beer Sheva,
Module 4 showed an Autism Spectrum Disorder (ASD) diagnosis.
Most remarkable impairments were detected in communication Israel; 2 Ben-Gurion University of the Negev, Zlotowski Center for
and social reciprocity areas. Neuroscience, Beer Sheva, Israel; 3 The Open University, Education
Conclusions.– KS may involve neuropsychological impairments. and Psychology, Ra’anana, Israel; 4 Tel Aviv-Yaffo Academic College,
However, they are rarely intelectually disabled. Language disabil- School of Behavioral Sciences, Tel Aviv-Yaffo, Israel
itys are the most common identified in children with KS. They
also show impairments in social and emotional cognition, with Background and aims.– Preterm birth accounting for 11% of all live
difficulties in expressing emotions and decoding and interpret- births worldwide, represents a major challenge to public health. It
ing another’s emotions and facial expressions. Psychiatric disorders is well-established in literature that premature birth is associated
related to dysfunctions in social cognition, such as ADS, should be with neurodevelopmental impairments in a vast range of domains,
considered in differential diagnosis in order to improve the clinical including impairment in motor development, cognitive function-
and psychopedagogical management. These disorders may be the ing and vulnerability to anxiety disorders. We propose a preterm
underlying cause of behavioral disturbances, as in the clinical case birth mouse model of anti-progesterone RU486 injection to bet-
that we describe. ter understand the link between prematurity and behavioral and
Disclosure of interest.– The authors have not supplied a conflict of biological outcomes in the offspring.
interest statement. Methods.– Preterm labor was induced by injecting 150 ␮g of the
anti-progesterone RU486 into pregnant mice at day 17 of gesta-
tion, which resulted in parturition of 91 live pups within 18 hours.
E-PV0080
Normally, the full gestation period of ICR mice is 20–21 days.
Trends and outcomes in child and We tracked the pup’s weigh, and tested the pup’s motor abilities
adolescent mental health (righting reflex test), cognitive functioning (Morris Wate-Maze and
emergencies: a 7-year follow-up study Ymaze) and anxiety-like behaviour (Elevated Plus-Maze) at the age
Á. Fernández-Quintana1* , A. Novo-Ponte2 , C. Quiroga-Fernández2 , of 60 days. In addition, we measured the pups’ BDNF levels in the
R. Mendez-Iglesias2 hippocampus, PFC, striatum and hypothalamus at birth and adult-
1 Clinical Hospital of Västmanland, Psychiatry, Västerås, Sweden; 2 hood.
Clinical University Hospital of La Coruña, Psychiatry, La Coruña, Spain Results.– In comparison to full-term born mice, preterm-born
* Corresponding author. mice weighed significantly less along different ages, demonstrated
poorer performances in righting reflex test, Ymaze, MWM, EPM,
Background and aims.– Children and adolescents require increasing and had higher BDNF levels at birth and adulthood in the hippocam-
numbers of visits to psychiatry emergency departments (ED). pus.
Aims.– To underpin sociodemographic and clinical variables asso- Conclusions.– The RU486 injection preterm-birth model is success-
ciated with an upward trend in ED visits. To analyse diagnostic ful in inducing preterm birth in mice, enables an experimental
stability over the follow-up. investigation of the developmental impairments associated with
Methods.– Retrospective study of 160 patients aged under 17 years prematurity and the biochemical mechanisms underlying these
who attended ED due to psychiatric concerns over a 7-year period impairments. Our data indicates that preterm-born mice demon-
(2010–2017). strate motor and cognitive difficulties, and show vulnerability to
Results.– Mean age 14,62 years (SD: 2,15). 52,5% females. Prevalence anxiety-like behavior.
of ED visits spanning from 14,4% in 2010 to 25% in 2016. 71,3% lived Disclosure of interest.– The authors have not supplied a conflict of
in urban settings, 51% of parents were divorced. Most prevalent interest statement.
causes of ED visits: aggressive behaviour in males (56%), self-harm
in females (40%). Personal history of suicide attempt was signifi-
cantly more prevalent among females (p < 0.001). Severe problems E-PV0082
of primary support group detected in 25,8% of subjects. Somatic The validity of child and youth
history: epilepsy (10,1%), coeliac disease (6,3%), diabetes (5,7%),
depression diagnoses in the danish
heart disease (1,9%), thyroid disease (1,9%), cerebral palsy (1,3%).
89,9% had a prior psychiatric diagnosis: Conduct Disorders (40,6%), central psychiatric research register
ADHD (16,3%), Major Depression (11,9%). 73% received psychophar- L.H. Frederiksen1* , N. Bilenberg1 , L. Andersen2 , N. Henriksen2 , B.
macological treatment prior to ED admission (44% antipsychotics, Lyng-Rasmussen3 , R. Wesselhöft1
1 University of Southern Denmark, Research Unit of Child and
43% benzodiacepines, 30% antidepressants, 14% mood stabilizers,
11% stimulants). 12% abused drugs (THC being the most prevalent). Adolescent Mental Health- Department of Clinical Research, Odense,
Alcohol abuse was significantly more prevalent among females Denmark; 2 Mental Health Services in the Region of Southern
(p = 0,026). Psychiatric family history positive in 42% of cases. Denmark, Department of Child and Adolescent Psychiatry Odense,
Inpatient admission rates: 13,2%. Attendance to first follow-up Odense, Denmark; 3 Hospital Lillebælt, Department of Paediatrics,
appointment: 78,1%. 57,8% collected ED prescriptions. Diagnostic Kolding, Denmark
stability over 7 years: 73%.
Conclusions.– Significant gender differences were noted among Background and aims.– All psychiatric diagnoses assigned for inpa-
children and adolescents who attend ED. Low rates of compli- tients and outpatients in Denmark are recorded in the Danish
ance to ED prescriptions and deficits in follow-up care need to be Central Psychiatric Research Register (DCPRR). Danish register-
addressed. based studies have contributed significantly to international
Disclosure of interest.– The authors have not supplied a conflict of psychiatric research, however to be able to use registries for obser-
interest statement. vational studies it is imperative that the clinical diagnoses recorded
are valid. Validation studies of the depression diagnosis have been
carried out for adults, supporting that the depression diagnosis E-PV0084
is valid in the DCPRR. However, no studies have so far examined Body mass index and their changes
the validity of the depression diagnoses assigned for children and
among child and adolescent patients
adolescents.
The objective of this study is to investigate the validity of first onset with psychotic versus non-psychotic
depressive episode (DE) diagnoses in the PCPRR for children aged disorders
6–17 years. Furthermore, the study will examine if there is a dif- S.P. Gomes Da Costa1* , A. Gomez2 , A. Gimenez1 , G. Anmella1 , J.
ference in validity between the different severities of DE, and if Pinzon1 , P. Guzman1 , A. Morer3 , I. Baeza3
1 Hospital Clinic, Psychiatry - Clinical Institute of Neuroscience,
there is a higher validity among those patients who are prescribed
antidepressant medication. Barcelona, Spain; 2 Universidad de Antioquia, Psychiatry, Medellin,
Methods.– The study is a population-based study using a ran- Colombia; 3 Hospital Clinic, Child and Adolescent Psychiatry - Clinical
dom sample nested within a cohort of all Danish children and Institute of Neuroscience, Barcelona, Spain
adolescents diagnosed with DE. The PCPRR is used to identify a
cohort of 500 children and adolescents assigned with a first onset
Background and aims.– Despite the increasing use of psychotropic
DE between 1996–2016. The validity is determined by review-
medications in children and adolescents, and the concerns about
ing hospital charts to see if the ICD-10 diagnostic criteria are
their metabolic side effects, data regarding their safety are limited
met.
and mostly focused on psychotic disorders. There are few studies
Results.– Data collection will start November 2018. Preliminary
evaluating metabolic repercussions of psychotropic medications
results will be presented at EPA April 2019 in Warsaw.
in other psychiatric disorders, where the use of antipsychotics is
Conclusions.– The study can provide important information about
widespread. The aim of this study is to analyse the differences in
the usefulness of the DCPRR in child and youth depression research.
BMI (Body Mass Index) and weight change between patients with
psychotic and non-psychotic disorders during their attendance to
interest statement.
a day hospital.
Methods.– A retrospective analysis of the clinical records of all
E-PV0083 patients between 12 and 18 years old, who were admitted to our
Child and Adolescent Psychiatry Day Hospital during 2016 was car-
PRE-validation of a battery of ried out. Patients with eating disorders were excluded.
Tunisian social cognition tests Results.– From the initial sample of 48 patients, BMI was recorded
M. Ghazzai* , A. Taamallah, O. Rajhi, M. Moussa, S. Halayem, Z. in 36 patients. Fifteen patients (41,6%) had psychotic disorders
Abbes Ghorbel Salma, M. Hajri, A. Bouden (Schizoprenia, Bipolar, Schizoaffective or non-specified psychosis)
Razi Hospital, Department of Child and Adolescent Psychiatry, and 21 had other mental disorders, showing a mean BMI, adjusted
Mannouba, Tunisia by age and gender, of 23,75 and 23,68 respectively, with a mean
increase of BMI during hospitalization of 1,42 and 1,38 respectively.
The percentage of patients receiving antipsychotic medications
Background and aims.– To better understand and assess the devel-
were 93.3% in psychotic disorders group and 85,7% in the non-
opment of social skills among Tunisian children with typical
psychotic group.
development, we created a battery of assessment tools for emo-
Conclusions.– Our study didn’t find significant differences between
tions’ recognition, mentalization and empathy.
BMI or BMI change among the diagnostic subgroups, with a high
Objectives.– Validate each test in children population to establish
prevalence of antipsychotic utilization in non-psychotic group. The
normative references.
metabolic concerns established for psychotic patients should not
Methods.– The Participants are Tunisian children without mental
be undervalued in non-psychotic patients, and longitudinal studies
retardation and psychiatric disorders aged between 7 and 11 years
evaluating the metabolic disturbances in non-psychotic patients
old.
are needed.
Recognition of Facial Emotions: Tunisian Test for Children
(FETTC): consists of photographs and videos representing the 6
interest statement.
basic emotions and neutrality.
Tunisian Emapthy Scale for Children (TESC): measures the
components of Empathy. Tunisian Social Situations Instrument E-PV0085
(TSSI): a verbal test for theory of mind,
Picture Sequencing: a non-verbal test for theory of mind. Examining the relation among the
Results.– methods of parenting and creativity of
FETTC: There was a positive correlation between empathic attitude high school girls students on Sari city
and age, r = 0.423, n = 46, p = 0.003. S. Heydari1* , M. Shafiei Amiri2
TESC: The total score of empathy was significantly higher among 1 Islamic Azad University, Clinical Psychology, Qazvin, Iran; 2
girls. There was a positive correlation between between the cog- Islamicazad University of Sari, Clinical Psychology, Sari, Iran
nitive empathy attitude and mental age, r = 0.486, n = 60, p = 0.025. * Corresponding author.
TSSI: There was an improvement in the global score with

mental age, and school level without an identified celling Background and aims.– Cancer is a disease that all human beings
effect. are afraid of it and anyone, of any age may be affected. The objec-
Picture Sequencing: There was an improvement in the global score tives of this research are relationship between wellbeing and life
with age, and a ceiling effect around 9 years old.Conclusions.– These expectancy in patients with cancer in Noshahr Shahid Beheshti
results are encouraging and will be discussed in the light of litera- hospital is the general purpose of this research.
ture data. Studying the relationship between happiness, general health and
* Corresponding author. life expectancy of cancer patients.
Methods.– This study is of descriptive type and the method of study
Disclosure of interest.– The authors have not supplied a conflict of is correlation one. Statistical society of study includes all girls’ stu-
interest statement. dents of high school degree on sari city in which includes about
1400 persons.
Results.– Sampling has been done by the aid of kerjtis- Morgan table Background and aims.– The aim of this case is to perform a review
and about 203 persons has been selected by method of random- of psychosis in autisim spectrum disease (ASD).
categorical method. Gathering standard questionnaire instrument Methods.– 8-year-old woman with a previous diagnosis of ASD,
of Bamrind parenting practices methods includes 30 questions and attended for presenting delusional and hallucinations symptons.
also Abedi creativity questionnaire includes 60 questions has been The patient reported that there was a fantasy world, with imag-
used and parenting practices, creativity method questionnaire sta- inary beings, with whom she was able to communicate. She said
bility has been examined through Cronbach’s alphaand its amount that she felt how those beings touched her and talked with them.
(8.86-0.83)has been calculated, respectively. In order to analyze She described that when she was alone, she heard voices inside her
data, we have used of Pearson correlation test by the aid of SPSS head that she related to these beings. He also explained that she
software. had a certain function in that fantasy world. In addition to ASD,
Conclusions.– The result of study has shown there is relation among she was diagnosed with psychotic symptoms. was treated with
the methods of parenting practices and creativity of students. Easy antipsychotics, achieving complete remission of symptoms.
parenting practices, autocratic parenting and authoritarian par- Results.– In the psychiatry of the 70s, no distinction was made
enting respectively are the strongest anticipating the amount of between psychosis and ASD. It is a very controversial topic, because
students’ creativity. many of the symptoms of ASD can be confused with psychotic
Disclosure of interest.– The authors have not supplied a conflict of symptoms. Especially, there is a difference in boys with ASD and
interest statement. girls. The latter present a fantasy world much more structured
than children with ASD and have a lower degree of difficulty for
social interaction. For this reason, in girls, it is difficult to make the
E-PV0086 diagnosis of psychosis and in addition, ASD is diagnosed later.
Psychiatric morbidity among the Conclusions.– It is difficult to make a differential diagnosis between
patient of first ever ishchemic stroke both pathologies. However, early diagnosis of psychotic symptoms
M. Inam is essential to establish the antipsychotic treatment in the earliest
BMDC, Psychiatry, Kulaura, Bangladesh way, to improve the prognosis.
interest statement.
Background and aims.– Stroke is the most common cause of
mortality worldwide and a serious cause of disability in the
community. Stroke affects not only physical but also emotional, E-PV0088
psychological, cognitive, and social aspects of patients. Some of Early onset psychosis in a
the neuropsychiatric disorders associated with stroke include post pre-adolescent male with a history of
stroke depression (PSD), bipolar disorder, anxiety disorder, apathy
exposure to pre-natal maternal
without depression, psychotic disorder and catastrophic reaction.
Aims.– To evaluate psychiatric morbidity among the patients of first infection and hydronephrosis
ever ischemic stroke. M. James* , U. Mihir, M. Jennings, P. Korenis, S. Gunturu
Methods.– This cross sectional comparative study was carried out Bronx Care Hospital System, Psychiatry, New York, USA
in the Department of Psychiatry, Sylhet MAG Osmani Medical Col-
lege Hospital. 66 ischaemic stroke patients of first attack between
Background and aims.– Maternal infection during pregnancy can
2 weeks to 2 years of stroke, aged above 18 years irrespective of
be associated with a number of adverse post-natal outcomes.
sex and 66 accompanying healthy person of the patients and other
These complications are attributable to an ever-growing list of
patients without any kind of stroke matching age and sex fulfill-
bacteria and viruses responsible for vertical transmission of infec-
ing inclusion and exclusion criteria were taken in Group-A and
tion in utero, during delivery, or while breastfeeding. Even with
Group-B respectively. Exclusion criteria were patients with tran-
advancements in prevention, diagnosis, and treatment of maternal
sient ischaemic attack, haemorrhagic stroke, previous stroke, head
infections, the limited epidemiology and etiology data is a barrier
injury, known psychiatric disorder, serious cognitive impairment
to implementing effective public health measures.
and other chronic diseases that may cause psychiatric morbidity.
Methods.– We present the case of a 10-year-old African Ameri-
Results.– Co-morbid specific psychiatric disorders were generalized
can male born to an African mother who migrated from Ghana
anxiety disorder in 13.6% and major depressive disorder in 21.2% in
shortly after she realized she was pregnant with the patient. In
stroke group; while co-morbid specific psychiatric disorders were
utero, patient was exposed to maternal infections that included
generalized anxiety disorder in 3.0% and major depressive disorder
Toxoplasmosis and Cytomegalovirus. He was brought to the hospi-
in 10.6% respondents in control group.
tal after experiencing command auditory and visual hallucinations
Conclusions.– Co-morbid psychiatric disorders are quite common
for six months to stab his younger sister with a knife.
among patients with first ever ischaemic stroke in the form of major
Results.– With appropriate measures, there has been a substantial
depressive disorder and generalized anxiety disorder. Therefore,
reduction in neonatal morbidity and mortality, and better miti-
attention should be paid to the anxiety and depressive symptoms
gation of adverse effects to the newborn. However, the impact of
in stroke units.
maternal infection can linger long after the infection has resolved,
and consequences may arise years later, including psychiatric com-
interest statement.
plications. Among the after-effects is the potential for psychosis, a
broadly-defined psychiatric term for symptoms that cause an indi-
vidual to have sensory experiences without stimuli or beliefs not
E-PV0087
based in reality.
Psychosis in autism spectrum disease: Conclusions.– In studying this case, health care practitioners may
report a case better recognize the prodromal symptoms of psychosis in patients
A. Izquierdo De La Puente* , P. del Sol Calderón with a history of exposure to maternal infection, allowing for
Universitario Puerta de Hierro de Majadahonda, Psychiatry, Madrid, potential control of symptoms to avoid exacerbation leading to
Spain debilitation.
interest statement.
E-PV0089 phone addiction scale at 3 community based children’s mental

FASD – the impact on a patient’s life health centers. Statistical analyses including the Pearson’s corre-
and his/her social and family lation test and multiple linear regressions were performed in this
study.
environment Results.– Maternal depression were most highly associated with
P.S. Katarzyna* , D. Puzio, A. Gmitrowicz, I. Makowska
the young children’s behavioral problems (OR 6.422, p < .001). The
Medical Uniwersity of Lodz, Clinic of Adolescent Psychiatry, Łódź,
externalized behavioral problems (OR 6.336, p < .001) were much
Poland
associated with the maternal depression than the internalized
behavioral problems (OR 5.261, p < .001). Maternal smartphone
Background and aims.– Fetal Alcohol Spectrum Disorder (FASD) addiction (OR 1.628, p = 0.11) and maternal anxiety (OR 2.778,
is a broad term which encompasses neurodevelopmental abnor- p = 0.08) were associated with the children’s internalized behav-
malities caused by maternal alcohol intake during pregnancy. It ioral problems, but it was not significant.
comprises Fetal Alcohol Syndrome (FAS), Partial Fetal Alcohol Syn- Conclusions.– Maternal depression has a greater impact on the chil-
drome (pFAS) and Alcohol Related Neurodevelopmental Disorder dren’s internalized and externalized behavioral problems than any
(ARND). A full-blown FAS is characterised by facial dysmorphology, other factors. Therefore, prevention and treatment of maternal
growth retardation, low body weight, microcephaly and specific depression are the most important for the mental health of the
central nervous system (CNS) damage. Prenatal alcohol exposure young children.
may also impair organogenesis of organs other than brain causing Disclosure of interest.– The authors have not supplied a conflict of
their structural and functional anomalies. Since other FASD con- interest statement.
ditions have a range of presentations, diagnostic process in these
cases requires professionals’ cooperation in a multidisciplinary
E-PV0091
team.
Methods.– We would like to present common problems experi- Influence of prematurity on
enced by patients diagnosed with FASD and their families based on neurocognitive abilities in children at
a case study. Family, educational, legal and occupational aspects of 14 months of age
patient’s life will be discussed from birth, throughout early child- S. Kiselev1* , E. Suleymanova2 , N. Bakushkina2 , I. Tuktareva2
hood and adolescence to adulthood. We will demonstrate the role 1 Ural Federal University Named by the First President of Russia B.N.
of early diagnosis for better future functioning. Yelsin., Clinical Psychology and Psychophysiology, Ekaterinburg,
Results.– Patients with FASD might not be understood by others and Russia; 2 Ural Federal University Named by the First President of
might show impairments in social functioning. The burden stem- Russia B.N. Yelsin., Laboratory for Brain and Neurocognitive
ming from physical malformations may hamper educational and Development, Ekaterinburg, Russia
employment activity. CNS damage may cause poor understanding * Corresponding author.
of social rules, disability to foresee consequences and poor judge-
ment. This in turn leads to secondary disabilities such as impaired Background and aims.– It is known that premature children have a
social bonding and conflicts. risk for neurodevelopmental disorders [Anderson & Doyle, 2008].
Conclusions.– Poster underscores the significance of early and ade- There is not enough data about the impact of prematurity on
quate diagnosis of FASD in order to improve health condition as neurocognitive development in young children. We have shown
well as social, educational and occupational abilities of affected that prematurity has negative effect on cognitive scale, receptive
individuals. language and gross motor from the Bayley Scales (3rd Edition)
Disclosure of interest.– The authors have not supplied a conflict of in infants at 5 months of age (Kiselev et al., 2017). The aim of
interest statement. study was to reveal differences in development of neurocogni-
tive functions in mature and premature infants at 14 months of
age.
E-PV0090 Methods.– The participants were 23 premature infants and 25 age-
Analysis of factors that influence the matched healthy full-term infants. The gestational age of preterm
infants was between 29 and 35 weeks. The Bayley Scales (3rd Edi-
young children’s internalized and
tion) were used to evaluate the neurocognitive abilities in infants
externalized behaviors at 14 months of age.
S. Kim1* , S. Cho1 , M. Jang2 , H. Han1 Results.– One-way ANOVA was used to reveal group differences in
1 Ajou University School of Medicine, Department of Psychiatry and performing tasks from the Bayley Scales. We have revealed the sig-
Behavioral science, Suwon, Republic of Korea; 2 National Center for nificant differences (p < .05) between groups only in gross motor.
Mental Health, Department of Psychiatry, Seoul, Republic of Korea Premature children performed significantly more poorly than the
full-term infants on this scale. However, we did not find the same
Background and aims.– Multiple factors including Parental fac- result for fine motor, cognitive scale and receptive and expressive
tors, children’s factors and environmental factors has known to language.
influence the various behavioral problems of the young chil- Conclusions.– It can be assumed that prematurity has a specific
dren. But There have been continuing concerns about the extent negative effect on neurocognitive functions of children in dif-
to which factors may influence maternal reports of children’s ferent stage of development. Particularly, the prematurity has
behavior. more negative effect on neurocognitive abilities at 5 months
The aim of the present study was to identify parental, chil- of age in comparison to premature children at 14 months of
dren’s and environmental factors that influence the internalized age.
and externalized behavior among Korean children from ages This work was supported by grant Russian Science Foundation №
3–5. 16-18-10371.
Methods.– In 2014–2015, the parents of 400 children aged 3
to 5 years (207 boys and 193 girls, mean age 3.86 ± 0.8 years)
were surveyed using a questionnaire on the family life style,
interest statement.
children’s behaviors and temperaments and the parental mental
health including parenting stress index, BDI, BAI, internet & smart-
E-PV0092 (WISC-IV). Individuals with a below normal inteligence quotient

Is own body really aversive stimulus (IQ) were exculuded. Sociodemographical and clinical variables
in eating disorder? is their subjective were collected in order to study posible short term pronos-
tic differences between groups (comorbid diagnosis, treatment,
and physical reaction similar? follow-up, academic performance and social functioning with
T. Knejzlikova* , M. Svetlak
peers).
Faculty of Medicine- Masaryk University Brno- Czech Republic,
Results.– A total of 68 patients diagnosed with ASD and 15 with SCD
Department of Psychology and Psychosomatic, Brno, Czech Republic
were included. No gender or age, and family socioeconomical level
differences were found between groups. Differences in IQ were
Background and aims.– Disturbance perception of body shape and found, being higher statiscitaly significant in the SCD (p = 0.039).
body dissatisfaction are one of the main clinical symptoms of Furthermore, ASD showed higher scores in the ADI-R B (p = 0.24)
anorexia nervosa. Subjective perception of their own body is non- domain when compared to the SCD. No statisticaly significant dif-
realistic and often is very different from ideal body, which eating ferences were found regarding comorbidity, follow-up, academic
disorder (ED) patients want to have. Disturbed body image play an performance and social functioning. Analysis showeds ASD patients
important role in development and maintenance of eating disor- were more likely to have psychofarmacologic treatment (p = 0.045).
der. During therapy, they slowly become accustomed to their own Conclusions.– Our findings suggest that the clinical differences
self-image, accepting it more. In general, a view of the body, either observed between ASD and SCD may account, at least in part,
supposed, or real in the mirror, represents one of the most aversive to between group differences in psychopharmacologic treatment.
stimulus for girls with eating disorders. No differences in the proposed pronostic outcomes were found
Methods.– Thirty-two adolescent girls with restrictive type of between ASD and SCD.
anorexia nervosa and thirty-three health controls (HC) were Disclosure of interest.– The authors have not supplied a conflict of
repeatedly exposed to own body in the mirror and physiological interest statement.
activity (ECG, skin conductance) was measured during experiment.
Subjects were rating their emotional reaction on SAM scale after
E-PV0094
mirror exposure.
Results.– We hypothesize, that girls with ED will have increased Treatment of ADHD in children with
stress reactivity indexed to mirror exposure than HC. We also congenital heart diseases: a literature
expected significant discrepancy between subjective evaluation of review
exposure indexed by SAM and objective physiological reactivity P. Manocha1* , D. Bhullar1 , H. Raai2 , M. Zeshan3
in ED group. The results of the present study demonstrate that 1 BronxCare Health System, Psychiatry, Bronx, USA; 2 Montefiore
ED group experienced higher negative and intensive emotional Medical Center, Psychiatry, Bronx, USA; 3 Boston Children Hospital-
response to body exposure compare to HC and showed higher Harvard Medical School, Psychiatry, Boston, USA
physiological arousal in skin conductance. We could not confirm * Corresponding author.
the paradoxical relationship between the subjective and objective
response to mirror exposure in patients. Background and aims.– With recent advances in medicine, mor-
Conclusions.– This report was written with the support of the Spe- tality rates in children and adolescents with complex congenital
cific University Research provided by MŠMT, MUNI/A/0976/2017. heart disease (CHD) have gone down, which has lead to increased
Disclosure of interest.– The authors have not supplied a conflict of incidence of complex neurodevelopmental (ND) and behavior
interest statement. pattern such as learning disabilities, impairments in core com-
munication skills, as well as inattention, impulsive behavior, and
impaired executive functions. Since treatment of ADHD requires
E-PV0093 medications such as amphetamine based stimulants, alpha 2
Differences in sociodemographgic and adrenergic agonist, as well as noradrenergic agents all known
to cause cardiac effects, the safety of these medications use in
clinical characteristics between kids
children with underlying cardiovascular abnormalities has been
and adolescents diagnosed with social concerning.
(pragmatic) communication dissorder Methods.– Literature was searched using key terms “Treatment
and autisim spectrum disorder of ADHD” and “Congenital Heart Disease” for articles indexed in
acroding to DSM-V criteria PubMed and Google Scholar in last 10 years.
S. Madero1* , A. Blazquez2 , A. Ortiz Encarnacion2 , E. Varela2 , R. Results.– Literature suggests that early identification of these ND
Calvo2 , O. Puig2 , L. Lazaro2 impairments and intervention by treating these symptoms is the
1 Hospital Clinic of Barcelona, Department of Psychiatry and better approach in minimizing future disabilities. ADHD medica-
Psychology, Barcelona, Spain; 2 Hospital Clinic of Barcelona, tions increase the dopamine level and thus improving neurological
Department of Child and Adolescent Psychiatry and Psychology functioning. They also affect cardiac functioning by affecting heart
Hospital Clinic of Barcelona, Barcelona, Spain rate and blood pressure. There has been consensus that all patients
* Corresponding author. treated with ADHD medications require continued surveillance of
heart rate and blood pressure, but there are no practice parameters
Background and aims.– Introduction: The recently introduced social for risk assessment before initiation of pharmacologic therapy for
(pragmatic) comunication dissorder (SCD) differentiatates from ADHD.
autism spectrum disorder (ASD) in both the restricted interests and Conclusions.– None of the studies have shown any evidence of
repetitive conducts [1], absent in SCD. Its phenomenological base increased risk of sudden death in-patient receiving stimulants or
is widely controverted and requires further research [2,3]. any other ADHD drugs. Coordination of care between the primary
Objectives.– Analyse the clinical and sociodemographical charac- care physician, the ADHD medication-prescribing physician, and
teristics between patients diagnosed of ASD and SCD according to the pediatric cardiologist may be an important component of treat-
DSM-V criteria. ment.
Methods.– A retrospective analysis of database information includ- Disclosure of interest.– The authors have not supplied a conflict of
ing 83 clinical records that fulfilled criteria for ASD and SCD interest statement.
diagnosis acording to DSM-V and the autism diagnostic interview –
revised (ADI-R). The neuropshycological battery were also included
E-PV0095 Hospital Universitario Puerta de Hierro-Majadahonda, Department

The use of transcranial magnetic of Psychiatry, Majadahonda, Spain
stimulation in autistic spectrum
disorders with predominance of Background and aims.– The hypothalamic-pituitary-adrenal (HPA)
speech impairment axis is the main regulator of the stress response and its malfunc-
M. Marachev* , A. Grigorieva, M. Sheina, I. Kazachenko, A. Kostileva tion may underlie the etiology of mental disorders. The role of
Centre for Medico-Psychological Correction and Rehabilitation HPA axis in psychopathology has been scarcely studied in child
“Neurocentre”- Moscow- Russian Federation, Centre for and adolescent populations. The aim of this study is describe
Medico-Psychological Correction and Rehabilitation “Neurocentre”- the HPA axis reactivity - assessed by Trier Social Stress Test
Moscow- Russian Federation, Moscow, Russia (TSST)- in a representative sample of children and adolescents
* Corresponding author. (affected and non-affected by psychiatric disorders) from the Span-
ish multicentric EPI Young Stress Project.
Background and aims.– The worldwide population prevalence Methods.– We analyzed a preliminary sample of 135 children from
Autism spectrum disorders (ASD) is about 1% (Meng-Chuan Lai 7 to 17 years old: 84 with psychiatric diagnosis (K-SADS-PL) and
et al., 2013). Symptoms of ASD include a violation of social 50 healthy stratified controls. Pubertal stage was assessed by Tan-
interaction, interpersonal functions and atypical perception of ner stage: Children (Tanner stages I and II) and adolescents (Tanner
information. Thus, a possible correction includes a set of measures stages III, IV and V). All subjects were exposed to the TSST, a psy-
aimed at the maximum number of brain functions affected in the chosocial stress task which ensures the activation of the HPA axis.
pathological process. Saliva samples were collected at five time points during the pro-
To assess the effectiveness of TMS when combined with standard cedure to analyze the variability of cortisol as a proxy for HPA axis
therapy of ASD. activation.
Methods.– Children diagnosed with ASD (N = 8 mean age 7.25 ± 0.8), Results.– HPA axis reactivity increased according to Tanner stage.
the clinical evaluation method and the Childhood Autism Rating However, while pre-pubertal subjects displayed comparable levels
Scale (CARS) scale were used. All children underwent a course of of HPA axis reactivity during TSST, adolescent females exhibited
correction therapy with Speech-language pathologists and a devel- higher reactivity of HPA axis when compared with males. Affected
opment specialist (20 sessions per month), 4 children underwent subjects exhibited lower HPA axis reactivity after TSST when com-
15 additional procedures rTMS (DLPFC, 10 Hz, 30 imp (3 sec), 50 pared to controls.
train, 27 sec int). Conclusions.– HPA axis reactivity in front of a psychological stressor
Results.– CARS in the standard therapy group + TMS was signifi- was lower in subjects with psychiatric disorder. Both the pubertal
cantly better (mean score at the beginning of therapy was 46.7 ± 6.4 stage and sex influence the variability of HPA axis reactivity and
compared to 38.7 ± 3.3 at the end), compared with the group where have to be taken into account to understand the stress response.
only standard correction methods were used (mean score at the Acknowledgment:FIS PI15/00097.
beginning of therapy is 45.7 ± 4.9 vs. 42.2 ± 3.9)Subjective assess- Disclosure of interest.– The authors have not supplied a conflict of
ment of improvement in the standard therapy group + TMS by the interest statement.
parents was noted at 5–7 sessions, while in the other group (stan-
dard therapy) not earlier than the 15th session.
Conclusions.– The joint application of rTMS and standart therapy E-PV0097
leads to a more rapid dynamics in the state of children with ASD. Hidden high functioning autism – a
Mainly due to the improvement of speech function, greater con-
case report
centration and ordering of behavior.
M. Marques* , T. Cartaxo, V. Santos
CHUC, Child and Adolescent Psychiatry, Coimbra, Portugal
Background and aims.– High Functioning Autism (HFA) is charac-

E-PV0096 terized by the social deficits inherent to the diagnosis of autism but
Children and adolescents affected by whose higher IQ allows these individuals to have a better capacity
psychiatric disorders exhibit lower for learning and integration in society norms, often going unnoticed
HPA axis reactivity: the influence of and undiagnosed to older ages - adolescence or early adulthood.
However, the self-perceived difficulties of these individuals tend
sex and pubertal stage
to cause great anguish and anxiety, causing other symptoms that
L. Marques-Feixa1* , H. Palma-Gudiel1 , Á. Castro-Quinto2 , M.
can be confused with psychotic states.
Martín3 , M. Rapado-Castro4 , M. Mayoral4 , I. Zorrilla5 , M. Ramirez6 ,
Our aim is to raise awareness and illustrate how the difficulty in
S. Romero7 , I. Mendez7 , H. Blasco8 , M.J. Lobato8 , L. Fañanás1
1 University of Barcelona and CIBERSAM Mental Health Networking diagnosing this individuals can condition great suffering with the
Biomedical Research Centre, Department of Evolutionary Biology-
ogy.
Ecology and Environmental Sciences, Barcelona, Spain; 2 University
Methods.– Case report and revision of the most recent literature on
of Barcelona, Department of Evolutionary Biology- Ecology and
the topic with the key-words: “high functioning autism”, “misdi-
Environmental Sciences, Barcelona, Spain; 3 Hospital Benito Menni
agnosis”, “adolescence”.
CASM, Unidad de Crisis del Adolescente UCA, Sant Boi de Llobregat,
Results.– Male, 15 years old, without previous follow-up in Psy-
Spain; 4 Hospital General Universitario Gregorio Marañón and
chiatry. Between November and December of 2017 went to the
CIBERSAM Mental Health Networking Biomedical Research Centre,
emergency department several timeswith high anxiety, irritabil-
Child and Adolescent Psychiatry, Madrid, Spain; 5 Hospital Santiago
ity, insomnia and self-referential delirant ideas, culminating in an
Apostol and CIBERSAM Mental Health Networking Biomedical
episode of aggression in school and his suspension. He was hospi-
Research Centre, Department of Psychiatry, Vitoria-Gasteiz, Spain; 6
Mental Health Services Galdakao, Child and Adolescent Mental
outbreak. After a carefull evaluation he was diagnosed with HFA
Health, Galdakao, Spain; 7 Hospital Clinic of Barcelona and
and prolonged depressive symptoms, without somatic symptoms
CIBERSAM Mental Health Networking Biomedical Research Centre,
(ICD-9).
Child and Adolescent Mental Health Services, Barcelona, Spain; 8
Conclusions.– This adolescent did not have any previous monitoring Our aim is to characterize the cases hospitalized for SI, with and
or diagnosis that justified his difficulties. The parents were con- without VDI, and the prevalence of SIB, in an inpatient unit of Child
fused, not understanding what was happening. The school and the and Adolescent Psychiatry (CAP) since its opening (from Dec 2016
Hospital were also unprepared. This case illustrates the importance to August 2018).
of early detection and follow up as well as the education of their Methods.– Retrospective analysis of data collected from the elec-
care-takers. tronic clinical process.
Disclosure of interest.– The authors have not supplied a conflict of Results.– From the total number of cases (n = 107), 52.3% female,
interest statement. 34,6% (n = 37) had SI (70,3% female) and 27,1% (n = 29) had a VDI
(72,4% female). The total prevalence of SIB was 34,6% (n = 37). Of
those with VDI, 62,1% (n = 18) had at least one episode of SIB in
E-PV0098 their life history; in the group with SI, this value was 59,5% (n = 22).
Hidden high functioning autism – a Of the adolescents with IS, 40,5% (n = 15) had both VDI and SIB, and
case report only 3.7% (n = 4) of SI patients had neither.
M. Marques* , T. Cartaxo, V. Santos Conclusions.– Suicidal and para-suicidal behaviors were very fre-
CHUC, Child and Adolescent Psychiatry, Coimbra, Portugal quent in our inpatient unit, since almost a half of the total patients
* Corresponding author. presented with at least one VDI or SIB. This data is within the
expectations for an inpatient unit of adolescents compared to data
Background and aims.– High Functioning Autism (HFA) is charac- already described and alert us to the high prevalence of this type of
terized by the social deficits inherent to the diagnosis of autism but behavior and the importance of developing prevention and support
whose higher IQ allows these individuals to have a better capacity strategies in the community.
for learning and integration in society norms, often going unnoticed Disclosure of interest.– The authors have not supplied a conflict of
and undiagnosed to older ages - adolescence or early adulthood. interest statement.
However, the self-perceived difficulties of these individuals tend
to cause great anguish and anxiety, causing other symptoms that
can be confused with psychotic states. E-PV0100
Our aim is to raise awareness and illustrate how the difficulty in Differential diagnosis program and
diagnosing this individuals can condition great suffering with the early diagnosis of patients with
suspected autism spectrum disorders
ogy.
Methods.– Case report and revision of the most recent literature on at the hospital 12 de octubre of Madrid
the topic with the key-words: “high functioning autism”, “misdi- N. Martinez-Martin* , N. Gutiérrez Fernández, C.N. Acosta
agnosis”, “adolescence”. Velázquez, E. Pérez Valiente, J.C. Espín Jaime
Results.– Male, 15 years old, without previous follow-up in Psy- Hospital 12 de Octubre, Child and Adolescent Mental Health
chiatry. Between November and December of 2017 went to the Department, Madrid, Spain
emergency department several timeswith high anxiety, irritabil-
ity, insomnia and self-referential delirant ideas, culminating in an
Background and aims.– Autism Spectrum Disorder (ASD) is a neu-
episode of aggression in school and his suspension. He was hospi-
rodevelopmental disorder defined by certain behavioral features.
Although the symptoms occur in the early period of development,
outbreak. After a carefull evaluation he was diagnosed with HFA
these may not be fully manifested until social demands exceed the
and prolonged depressive symptoms, without somatic symptoms
limited capabilities of the child or may be masked by learned strate-
(ICD-9).
gies. Our aims is the early detection and intervention in order to
Conclusions.– This adolescent did not have any previous monitoring
improve the prognosis of the patients.
or diagnosis that justified his difficulties. The parents were con-
Aims.– Descriptive evaluation of the current status of the autism
fused, not understanding what was happening. The school and the
program.
Hospital were also unprepared. This case illustrates the importance
Methods.– Descriptive study of patients treated in the program from
of early detection and follow up as well as the education of their
May 2014 until October 2018.
care-takers.
- Inclusion criteria: children between 12 months old and 18 y-o,
previously assessed by Mental Health specialists and with diag-
interest statement.
nostic doubts or specific tests for its diagnosis.
- Exclusion criteria: children diagnosed with ASD.
The tests performed for the assessment are the observation scale
E-PV0099
for the diagnosis of autism spectrum disorder (ADOS-2), the diag-
Suicidal and para-suicidal behaviors nostic interview for autism reviewed (ADI-R), mentalization tasks
in a portuguese inpatient unit of child (storytelling, gaze test of Baron-Cohen for children, social stories of
and adolescent psychiatry F. Hapé).
M. Marques* , S. Neiva, R. Gonçalves, C. Ferreira, V. Santos Results.– N = 309; Boys: 267; Girls: 41; Tests performed: ADOS-
CHUC, Child and Adolescent Psychiatry, Coimbra, Portugal 2 = 150 (Module1 = 79, Module2 = 44, Module3 = 56, Module4 = 5,
* Corresponding author. Module T = 2); ADIR = 68; Diagnoses: No TEA = 72; PDD = 24;
TEA = 197.
Background and aims.– Suicidal ideation (SI) and suicide attempts, Conclusions.– The implementation of early detection programs of
particularly through voluntary drug intoxication (VDI), are frequent serious pathologies such as ASD is an important advance that allows
reasons for hospitalization in adolescent psychiatry wards. In addi- an early intervention, improving the prognosis in a significant pro-
tion, para-suicidal behaviors such as self-injurious behaviors (SIB) portion of children and also clarifies the doubts and distress of the
appear to be increasing in both adolescents with and without SI as parents
a mechanism of coping with problems. Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
E-PV0101 conduct disorder girls. In some studies no association was found

Genetic factors of the anxiety between Estradiol concentrations and aggression, in some an asso-
disorders formation in children ciation was found only when personality traits or low Cortisol
T. Matkovska1* , E. Mykhailova Matkovska2 , N. Bagatska3 , D. concentrations were equally present. Corrections for menstrual
Mitelov Matkovska2 , A. Goloborodko Matkovska4 cycle phase were lacking. Another limitation is that not every study
1 1SI «Institute for Children and Adolescents Health Care of the NAMS corrected for effects of Testosterone as gonadal precursor.
of Ukraine»- Ukraine- 2. V. N. Karazin Kharkiv National University- Conclusions.– Studies on Estradiol and aggressive behaviour or DBD
Ukraine, psychiatry, Kharkov, Ukraine; 2 SI «Institute for Children and produce mixed results, with some studies showing no associations,
Adolescents Health Care of the NAMS of Ukraine, Psychiatry, Kharkov, some only in boys or girls, or only when a mediating effect of emo-
Ukraine; 3 SI «Institute for Children and Adolescents Health Care of tional instability or negative life events occurred.
the NAMS of Ukraine»- Ukraine 2V. N. Karazin Kharkiv National Future studies should control for effects of Cortisol and Testos-
University- Ukraine, Genetic, Kharkov, Ukraine; 4 V. N. Karazin terone and use mixed gender samples, preferably after puberty
Kharkiv National University- Ukraine, 4 year, Kharkov, Ukraine onset as results of Estradiol assays are more reliable when taken
* Corresponding author. after gonadarche.
Background and aims.– At present, the concept of the role of the interest statement.
somatic mosaicism mechanisms (activation of the movement of
mobile genetic elements in the pathogenesis of mental disorders)
is suggested; it is supposed that one of the main causes of the E-PV0103
genome destabilization and changes in the system for maintain- Sexuality on asperger adolescents: a
ing the genome stability is the group of RNA-editing proteins AID / critical interaction solution and the
APOBEC. risk behind it
Methods.– our study included 90 families of children with the anx- M.M. Mihai1* , D. Iuliana2
iety disorders (AD) and 75 families with healthy children. Family 1 University of Medicine and Pharmacy “Carol Davila” Bucharest,
tree analysis was carried out using the method of P. Harper. The General Medicine, Bucharest, Romania; 2 University of Medicine and
cytogenetic analysis was performed in 50 children of 6–14 years Pharmacy “Carol Davila” Bucharest, Child and Adolescent Psychiatry,
with AD. The comparison group comprised 50 conditionally healthy Bucharest, Romania
age-matched children. * Corresponding author.
Results.– 72.2% of families have a hereditary load of mental illness.
Mental, neurological, cardiovascular, oncologic diseases prevail in Background and aims.–
the relatives of the probands. The coefficient of heritability is Introduction.– The issues regarding sexuality on adolescents diag-
h2 = 0.23, that is, the contribution of the hereditary component nosed with Asperger’s syndrome usually revolve more around
is 23.2%, and the environmental component comes to 76.8%. The inappropriate sexual behaviors and paraphilias and less around
level of spontaneous frequency of chromosomal aberrations in the consequences of augmented sexual interest combined with
blood lymphocytes of our patients is 5.31%, which is higher than the lack of social understanding. Furthermore, these two elements
that of the healthy peers (1.59%, p < 0.001). Dicentric chromosomes put together (limited sexual knowledge and experience, and social
have been revealed in 14% of children with AD, and chromosomal deficits) may place the patients at high risk of sexual victimization.
exchange has been established in 4% of such children, in the absence Objective.– The purpose of this study is to reveal a different side
of these disorders in healthy children. of sexuality in these patients, not as a part of the disorder, but as
Conclusions.– The performed study confirms the role of heredity in a dysfunctional mean to achieve social awareness and ultimately
the formation of AD and the need for differentiated treatment and acceptance.
prophylactic measures, taking into account the above-mentioned Methods.– This case report was based on a close monitoring and
disorders. frequent clinical and psychological tests performed on a singu-
Disclosure of interest.– The authors have not supplied a conflict of lar female patient, spanning from age 11 to 14, diagnosed with
interest statement. Asperger’s syndrome, temporary obsessive-compulsive behavior
and transitory psychotic episodes. Other underlying conditions of
the patient also include family history of mental illness and difficult
E-PV0102 upbringing.
Estradiol and aggressive behaviour in Results.– As a result of the inappropriate sexual behavior employed
boys and girls: a systematic review by the patient to gain social awareness from her peers, there were
P. Michielsen instances in which the adolescent was exposed to a high risk of
GGZ Westelijk Noord Brabant, Adult Outpatients Clinic, Halsteren, sexual abuse from an early age.
The Netherlands Conclusions.– The patient’s sexual behavior was only a part of the
* Corresponding author. cumulative obscene pattern of manifestations utilized in order to
achieve desired social interaction and integration, and could not be
Background and aims.– Disruptive behaviour (DBD) and aggression solely attributed to the underlining syndrome.
related disorders have been studied from a neurobiological and hor- Disclosure of interest.– The authors have not supplied a conflict of
monal perspectieve. If any contributing effects to psychopathology interest statement.
were found most notably adrenal hormones (DHEA, Cortisol) and
gonadal hormones (Testosterone) were mentioned. Less is known
about the role of Estradiol in the onset and maintenance of aggres- E-PV0104
sion and DBD in both boys and girls. The role of mirror neurons in terms of
Methods.– A systematic review was conducted using Ovid Medline, neurodevelopmental theory of autism
Psycinfo and Embase databases (up to 30 July 2018), using [estra-
diol] and [aggression] as search terms. Within the search results
spectrum disorder (ASD)-preliminary
only studies in humans and minors (age 0–18) were included. research
Results.– In total 9 studies were found in which Estradiol and M. Zietal1 , M. Mirek2* , A. Gmitrowicz3 , A. Wyderka1
1Psychologist, Daily Rehabilitation Psychiatric Unit for Children and
aggressive behaviour were used as (in)dependent variables. Only
one study tested hormone concentrations in a clinical sample of Youth in Clinic JiM, Lodz, Poland; 2 Psychiatrist, Daily Rehabilitation
Psychiatric Unit for Children and Youth in Clinic JiM, Lodz, Poland; 3 higher risk (95% CI 1.27-9.8) of having ASD compared to children
Psychiatrist, Department of Adolescent Psychiatry- Medical with normal vitamin levels.
University of Lodz, Lodz, Poland Conclusions.– The present study revealed that Vitamin D deficiency
* Corresponding author. was higher in ASD children compared to healthy children.
A supplementing with Vitamin D might be an effective strategy for
Background and aims.– In the 1990s Giacomo Rizzolatti and col- reducing the risk of ASD.
leagues discovered mirror neurons. Researchers confirmed this Disclosure of interest.– The authors have not supplied a conflict of
finding, clarifying their role in neurodevelopmental diseases (i.e. interest statement.
schizophrenia, ASD). Some studies indicate that dysfunction of mir-
ror neurons has an effect on abnormal visual communication in
patients with ASD. E-PV0106
This study is to examine the qualitative and quantitative differences Nutritional status in tunisian children
in the response of children with ASD and healthy children to the
with autism spectrum disorders
reflection in the mirror they perceive.
M. Chtourou1 , M. Naifar1 , R. Makhlouf1 , S. Grayaa2 , I. Hajkacem3 ,
Methods.– Based on the literature review, it was assumed that chil-
D. Ben Toumia3 , H. Ayedi3 , F. Ayedi1 , Y. Moalla3*
dren with ASD are different from healthy children in terms of visual 1 Habib Bourguiba Hospital, Biochemistry laboratory, Sfax, Tunisia; 2
perception disorders. The study group - 35 patients undergoing
University of Sfax - Medical School, Research Unit in Molecular Basis
rehabilitation at the Clinic JiM with the diagnosis of ASD according
of Human Pathology UR 12ES17, Sfax, Tunisia; 3 Hedi Chaker
to the DSM 5 classification confirmed additionally with ADOS 2 and
Hospital, Child Psychiatry Department, Sfax, Tunisia
the control group - 35 healthy children, selected in terms of sex and * Corresponding author.
age. A detailed examination protocol was developed, including the
approval of guardians. A ten-minute, non-invasive observational Background and aims.– Autism spectrum disorders is a severe devel-
study was conducted using a questionnaire, taking into account opmental disorder. Children with ASD are reported to have food
variables relevant to the study (i.e. fun time, way of play, child’s aversions inhabitual eating behaviors
reaction). The researcher will be a specially prepared psycholo- The aim of this study was to evaluate the nutritional status in
gist and doctor. Two educational tables covered with unbreakable Tunisian children with ASD.
mirror will be used, including one of them will be matted. The Methods.– This was a case–control study conducted at the depart-
examined child voluntarily chooses at which table they will play ment of child psychiatry. Forty children with ASD diagnosed
and how. according to the DSM-V criteria of the American Psychiatric Asso-
Results.– ciation were recruited. Controls included 43 sexe and age-matched
Conclusions.– We assume that the dysfunction of mirror neurons in randomly selected healthy children of the same socioeconomic
children with ASD will cause them to choose fun at a table with a status. We calculated body mass index (BMI). Total protein,
matte mirror. Obtained results may have diagnostic and practical albumin, prealbumin and Inflammatory markers (High Sensitive C-
implications in planning rehabilitation activities. Reactive Protein (CRP) us and orosomucoid) was measured for all
Disclosure of interest.– The authors have not supplied a conflict of subjects.
interest statement. Results.– Children with ASD had a lower BMI than the contrôle
groupe (16,82 ± 3,18 vs 19,08 ± 3,18 avec p = 0,016). The percent-
age of patients with a BMI at −1SD (12.8%), −2SD (7.7%) and −3SD
E-PV0105 (12.8%) was greater than the corresponding controls for each stan-
Vitamin D status in tunisian children dard deviation. The prealbumin concentration of the patients was
with autism spectrum disorders significantly lower than that of the controls (162.5 ± 45 mg / L
M. Naifar1 , M. Chtourou1 , R. Makhlouf1 , S. Grayaa2 , I. Hajkacem3 , vs 178.8 ± 29 mg / L, p = 0.046). Serum albumin, total protein and
D. Ben Touhemi3 , A. Grati1 , H. Ayedi3 , F. Ayedi1 , Y. Moalla3* Inflammatory markers were similar between the two populations.
1 Habib Bourguiba Hospital, Biochemistry laboratory, Sfax, Tunisia; 2 Conclusions.– Low values of serum prealbum suggest undernutri-
University of Sfax - Medical School, Research Unit in Molecular Basis tion or inflammatory syndrome. A small change in nutritional status
of Human Pathology UR 12ES17, Sfax, Tunisia; 3 Hedi Chaker can be detected early by the prealbumin levels. In this study, we did
Hospital, Child psychiatry Department, Sfax, Tunisia not notice an increase in CRP us and orosomucoid, and therefore
* Corresponding author. the decrease in pre-albumin levels in children with ASD would be
related to undernutrition.
Background and aims.– Autism spectrum disorder (ASD) is a severe Disclosure of interest.– The authors have not supplied a conflict of
developmental disorder. Vitamin D deficiency has recently been interest statement.
proposed as a possible environmental risk factor for ASD. Vitamin
D deficiency in early life affects neuronal differentiation, axonal
connectivity, dopamine ontogeny, and brain structure and function. E-PV0107
The aim of this study was to investigate and to determine the asso- The influence of new technologies in
ciation between Vitamin D and ASD.
adolescents and young people
Methods.– This was a case–control study conducted at the depart-
R. Molina Cambra* , M. García-Poggio Fernández-Renau, M. Eliche
ment of child psychiatry. Forty children with ASD diagnosed
Moreno, A. Muñoz Domenjó, Á. Martínez Fernández, E. Ramos
according to the DSM-V criteria of the American Psychiatric Asso-
García, R. Sagarra Arruego, F.L. Bianchi Ramos
ciation were recruited. Controls included 43 sexe and age-matched
Hospital Universitario de Móstoles, Psychiatry, Madrid, Spain
randomly selected healthy children of the same socioeconomic * Corresponding author.
status. Serum vitamin D was measured for all subjects. The level
P < 0.05 was considered as the value for significance. Background and aims.– Information and Communication Tech-
Results.– The mean age for autistic versus control children was nologies (ICT) have changed lifestyle of most of the population,
4,78 ± 0,93versus 4,76 ± 1,08, respectively. 60,6% % of autism chil- modifying how people relate to each other. The impact has been
dren had vitamin D deficiency. Vitamin D deficiency was consid- remarkable in all ages, but it highlights in children, adolescent and
erably more common among autistic children (17,13 ± 9,65 ng/ml young adults, where virtual world has as much reality as face-
ng/mL) as compared to healthy children (21,34 ± 8,1 ng/mL) to-face relationships and represents a way of fleeing from a daily
(P = 0.034). Children with vitamin D deficiency have a 3.5 times routine and getting lost in a fantasy universe.
To review the current situation of scientific knowledge on addiction E-PV0109

and abuse of new technologies by adolescents and young people, The alteration of the sensory
in order to describe and analyze the dangers entailed and to incise
consciousness of the self in children
the importance of prevention strategies.
Methods.– We review recent literature using PubMed and Mesh-
with developmental disorders. a
Database, related to several patients of our Child Psychiatry preliminary study
Outpatient Clinic. A. Bernardini, O. Orsini* , D. Montanaro
1 Freelance, Freelance, Rome, Italy
Results.– During adolescence there is a process of personal iden-
tity acquisition, with both physical and psychological changes
that make them emotionally vulnerable. Therefore, the prob-
Background and aims.– We assume that a relationship with a non-
ability of suffering from an addiction to new technologies
responsive caregiver could lead to an impairment of psychophysic
increases at these ages. Behavioral addictions exhibit similar
sensitivity fundamental to develop the “internal image of the Self”
characteristics of established addictions: inability to self-control,
(M. Fagioli, 2017).
psychological dependence and personal, family and social
Neurobiology studies indicate that the first years of life is
misadjustments.
characterized by intense neuronal plasticity, modulated by the
Conclusions.– Given the high prevalence of these type of addictions
developmental environment of children, with consequential mod-
in our society, we must value the need to apply psychoeducational
ification of the Nervous System (Giovanelli, 1997).
methods both in the family and at school. The aim of the treatment
Clinical studies (Atzori, 2017; 2018) highlight a correlation between
for new technologies addiction, unlike other addictions, cannot
a difficulty to constitute a mental configuration of a self ‘body
be total abstinence, but rather controlled use. The gold standard
scheme’ and an ‘impairment of the first internal image of the Self’
treatment appears to be stimulus control and gradual exposure,
(M. Fagioli, cit.), that originates at birth. This first internal image
followed by a cognitive-behavioral intervention in relapse preven-
represents a “Primal Self” that gives the newborn the certainty to
tion.
exist and the possibility to recreate homeostatics sensations and
good feelings in human relationships (M. Fagioli, 1971).
interest statement.
Methods.– This study examines the factors at the base of a develop-
mental alteration in a 5 year old girl with a mixed developmental
E-PV0108 disorder in psychomotor treatment, by structured clinical observa-
tion, drawing tests and praxic and motor activities.
Prevalence of depression and anxiety Results.– Observation and assessment aimed to evaluate the impair-
in a sample of normal iq adolescents ment of the mental configuration of the self body scheme at the base
with autism of motor difficulties, corroborate the hypothesis that it is linked to
V. Muñoz Martinez1* , B. Mata-Saenz1 , L. Asensio-Aguerri2 , L. an alteration of the “internal image” of the body impaired by non
Nuevo-Fernández3 , L. Beato-Fernández4 responsive relationship with the caregiver.
1 Hospital General Universitario de Ciudad Real, Psychiatry, Ciudad
Conclusions.– We propose that these difficulties can be gradually
Real, Spain; 2 Hospital General Universitario de Ciudad Real, Ciudad overcome in treatment based on a responsive relationship in which
Real, Spain; 3 Hospital General Universitario de Ciudad Real, Ciudad the child could recreate an inner image of the Self and body, through
Real, Spain; 4 Hospital General Universitario de Ciudad Real., Ciudad a constant stimulation of the psychophysical sensitivity.
Real, Spain Disclosure of interest.– The authors have not supplied a conflict of
interest statement.
Background and aims.– Anxiety and depression is frequent in Autism

during adolescence. The reason of that is because they perceived E-PV0110
their difficulties in social competence, which increase the risk of
Mental health problems among Polish
depression and anxiety. The objective of this study is to analyze the
relationship between anxiety and depression symptoms in individ- children and adolescents: preliminary
uals with autism and normal IQ. results of the MINI Kid survey
Methods.– 50 patients were recruited. The range of age was from 13 K. Ostaszewski1* , J. Moskalewicz2 , M. Kucharski2
1 Institute of Psychiatry and Neurology, Department of Public Health,
to 17 years old. The diagnosis was made using the ADOS-2. The IQ
were measured using the Wechsler Intelligence Scale for Children- Warsaw, Poland; 2 Institute of Psychiatry and Neurology, Department
4th Edition (WISC-IV) and the depression and anxiety symptoms of Studies on Alcoholism and Drug Dependence, Warsaw, Poland
with the Child Behavior Checklist (CBCL).
Results.– The mean age was 14.2 years old; men were the 92% of
Background and aims.– This study was the first national-wide survey
the sample and the women the 8%. The mean of the IQ was 109.1.
in Poland utilizing the Mini International Neuropsychiatry Inter-
The mean scores from the ADOS-2 were 12.3 (autism diagnosis).
view for Children and Adolescent (MINI Kid). It was a part of a
The mean age in atients with high scores in depression (CBCL > 64)
wider project called EZOP II that aimed at assessment of mental
was 15.7 years, the male had higher scores than girls (84% vs 16%),
health of the general population in Poland, including children, ado-
IQ mean score was 103.2 and the ADOS-2 mean scores were 11.5.
lescents and adult population. The study aim was to estimate the
Those individuals with high scores in anxiety, their mean age was
prevalence and determinants of mental and behavioral disorders
13.2, the men was the 73% of the sample and the women 27%.
in children aged 7–11 years and adolescents aged 12–17 years.
When we made the media scores of the IQ, the found that it was
Methods.– The latest version of the instrument based on classifi-
110.1. Finally, in this group the averages scores for the ADOS-2 were
cation system DSM-V (MINI Kid 7.0.2) was translated into Polish
12.3.
and used in the study. Computer-assisted personal interviewing
Conclusions.– We can say that emotional problem is a common
(CAPI) was conducted by trained interviewers among 2000 children
problem in ASD so we need to explore this symptoms because their
and adolescents randomly sampled from the population register.
difficulties to recognize their emotions.
Interviews with children were administrated with parental assis-
tance, while adolescents were answered the questions alone. Data
interest statement.
collection was completed in September 2018.
Results.– Preliminary results show a good response rate and sug- The aim of study was to present evolution of mental disorders and
gest a very high feasibility of MINI Kid instrument in the national personality development in a patient during the transitional period
epidemiological research. The analyses are in the process and will from puberty to legal adulthood.
be presented in the Congress. Methods.– Medical history was analyzed and description of the lon-
Conclusions.– The use of the clinical instruments in population sur- gitudinal course of mental disorder was done.
veys is a challenging task and requires a very good preparation both Results.– Case report: An 18-year-old male with a previous his-
in terms of interviewers training and logistics of the study. tory of cannabis abuse was hospitalized at psychiatric clinic due
Disclosure of interest.– The authors have not supplied a conflict of to manifestation of the phenomena of a psychotic syndrome, after
interest statement. refusing to voluntarily be hospitalized at a special hospital for
addictions. It was found that he has been using cannabis since his
14th year, almost daily, and parent divorce was marked as a trigger
E-PV0111 for cannabis, as well as alcohol abuse. In psychological status delu-
Sociodemographic characteristics of sions by themes of relation, persecution and omnipotence and no
adolescents with ADHD in states with hallucinations were recorded. Suicidal risk could not be excluded.
Routine laboratory findings, electorencephalogram and MSCT scan
recreational marijuana laws in the us
of endocranium were regular. MR angiography of head was found
R. Patel1* , M. Solanki2 , P. Mainali3 , A. Sadolikar4 , Z. Mansuri5
1 ecstatic and atherosclerotic alterations of left internal carotid artery
Griffin Memorial Hospital, Psychiatry, Norman, USA; 2 Washington
which caused suspicion of organic psychosis. Patient was treated
DC VAMC, Psychiatry, Washington, USA; 3 Zucker Hillside Hospital,
with pharmacotherapy and psychotherapy, but the treatment was
Psychiatry, Glen Oaks, USA; 4 Florida International University,
interrupted on a personal request. Two years later, the patient was
Internal Medicine, Miami, USA; 5 Texas Tech University Health
again hospitalized due to a worsening psychic condition, but treat-
Science Center, Psychiatry, Midland, USA
* Corresponding author. ment was again interrupted at the patient’s request. Psychological
testing showed a borderline personality organization.
Background and aims.– To determine the differences in sociodemo- Conclusions.– This study indicates that adolescence is extremely
graphic characteristics in adolescents with ADHD between states vulnerable period in personality development, and that biological,
with versus without recreational marijuana laws (RML). psychological and social factors act decisively.
Methods.– We used the nationwide inpatient sample (NIS) from Disclosure of interest.– The authors have not supplied a conflict of
2012–2014. We identified adolescents (12–18 years) with ADHD interest statement.
and cannabis use disorder as primary and secondary diagnosis,
respectively, using ICD–9 codes. They were divided into groups-
states with RML and non-RML Pearson’s chi square test was used E-PV0113
for categorical variables. A developmental perspective on Grief:
Results.– Majority of the cannabis users (CU) were 15-18 years death concept and reactions to loss
old (76.2% in RML and 78.9% in non-RML, P = .038). Male: female A. Salgueiro de Lima1 , C. Pires De Lima1,2* , S. Gonçalves1
ratio was 4:5 in non-RML whereas 47.6% females in RML were CU 1 ForAll - Desenvolvimento Pessoal e Bem-Estar- Unipessoal- Lda.,
(P = .002). About 71.4% CU in RML were Whites. In RML, CU with Psychology, Paredes de Coura, Portugal; 2 CINTESIS - Center for Health
ADHD were covered by private insurance (76.2%) and Medicaid Technology and Services Research- Porto., Psychology, Porto, Portugal
(23.8%), whereas in non-RML Medicaid covered 59.6% CU (P = .003). * Corresponding author.
CU in RML were from high-income families with household income

>75th percentile (76.2%) and in non-RML, about 58% CU were from Background and aims.– During development, children often expe-
low-income families with income < 50th percentile (P = .001). rience the loss of someone or something important to them (Corr,
Conclusions.– Females and adolescents 15-18 years with ADHD are 1996). Although their grieving process is similar to that of the adult
more likely to be CU in states with RML. CU in RML states are from (Worden, 1998), in this young age grieving is affected by prior expe-
high-income families. Inpatient management for ADHD is mostly riences and the level of development (Speece & Brent, 1984; Speece
covered by private insurance in these states. & Brent, 1996). Children’s understanding of death is strongly related
Disclosure of interest.– The authors have not supplied a conflict of to the cognitive development process (Speece & Brent, 1984).
interest statement. Methods.– Literature review.
Results.– In the initial stages of development children interact with
the world through their senses, acquiring a concrete understanding
E-PV0112 of their surroundings hence their death concept is based on physi-
“Walking on the edge”: from cal and functional aspects (Himelstein, Hilden, Boldt & Weissman,
2004). They progressively develop new skills and attain a more
adolescence to adulthood, from
complex concept of death. This understanding of death implies the
cannabis-induced psychosis to following dimensions: irreversibility, finality or non-functionality,
borderline personality disorder - case universality and causality (Speece & Brent, 1996; Schonfeld & Kap-
report pelman, 1990).
B. Pavkovic1* , M. Klacar2 Conclusions.– If we take the developmental perspective into con-
1 Health Center Dr Simo Milosevic Cukarica, Psychiatry, Belgrade, sideration it becomes possible to anticipate typical reactions to
Serbia; 2 Health Center Dr Simo Milosevic Cukarica, Pediatrics, loss in each developmental stage which allows us to adjust the
Belgrade, Serbia intervention to each child (Silva, 2009). The children’s grieving pro-
* Corresponding author. cess shouldn’t be underestimated, for it can negatively impact their
development. Therefore adults should include the children in the
Background and aims.– Numerous lines of evidence suggest a corre- family’s grieving process, be supportive and take care of them.
lation between cannabis consumption and a variety of psychiatric Disclosure of interest.– The authors have not supplied a conflict of
conditions, including cannabis-induced psychosis. interest statement.
E-PV0114 Results.– Mean distances in repertory grids were significantly high-

‘School refusal’ in the emergency est for self-aspects (Wicoxon-test, p < .01), and non-significantly
room lowest for adult elements. On self-report questionnaire patients
F. Reis* , T. Cartaxo scored significantly higher than controls (Mann-Whitney, p < .05)
Centro Hospitalar e Universitário de Coimbra, Serviço de Psiquiatria on Overall, Self and Friend scales, but not on Family Splitting scale.
da Infância e da Adolescência, Coimbra, Portugal In contrast, on TAT Affective scale the scores indicate more negative
* Corresponding author. and ambivalent attitudes towards both self and parental figures
then towards peers/siblings (Wilcoxon-test, p < .05). No signifi-
Background and aims.– School refusal occurs when a student rejects cant correlations between indexes from different instruments were
to go to school or regularly experiences severe distress related to found. Qualitative phenomena of self non-integration (Makhlouf-
school attendance, which can lead to school abstinence. It is impor- Norris, 1976) were found in 35% of repertory grids.
tant to address this problem, not only because of its consequences, Conclusions.– While self-representation is least coherent in eating
but mainly because of the diagnosis that it may be concealing. disorders, there is contrast between conformity of representations
The aim of this study is to characterize the patients observed for of parents and adults in cognitive tasks and ambivalent attitudes
‘school refusal’ in the child and adolescent psychiatric emergency manifested in projective assessment. Further study with qualitative
room throughout the year of 2017. analysis of thematic content is suggested.
Methods.– We compiled the episodes of observation for ‘school Disclosure of interest.– The authors have not supplied a conflict of
refusal’ in the child and adolescent psychiatric emergency room, interest statement.
during 2017, in the Centro Hospitalar e Universitário de Coimbra,
Portugal. We characterized the sample in terms of final diagnosis,
taking psychiatric medications, attending psychiatric consultations E-PV0116
and referral after the discharge. Factors associated with academic
Results.– There were 29 episodes of observation for ‘school refusal’. bullying profiles
The observed population was mainly masculine (58,6%), with an N. Sahar* , N. Halouani, M. Daoud, J. Aloulou, O. Amami
average age of 13,7 years old. The majority of these patients were Hedi Chaker University Hospital, Psychiatry B, Sfax, Tunisia
diagnosed with adjustment (34,5%), anxiety (31%), or depressive * Corresponding author.
disorders (24,1%). Also, 51,7% had no previous psychiatric consul-
tations, and 75,9% were not under medication. After the discharge, Background and aims.– Several factors seem to be associated with
93,2% had a follow-up consultation. the harassment profile of our students. It would be useful to discern
Conclusions.– The results showed that school refusing was related them in order to understand this growing phenomenon among our
to important psychiatric diagnoses, most of the times. These diag- teenagers.
noses included anxiety and/or depressive disorders that need - to discern profiles of harassment in a series of students
accurate interventions. - to determine factors associated with this profile
Therefore, it is especially important to correctly evaluate these situ- Methods.– It is a cross-sectional study of a series of 45 medical
ations, and inform caregivers this is not a behavior problem, but an students who answered a pre-established questionnaire explor-
important warning of distress which needs to be properly assessed, ing their sociodemographic data. We use the Bully / Victim revised
treated and followed. questionnaire that is a tool validated in French. It identifies, for
Disclosure of interest.– The authors have not supplied a conflict of each individual, whether or not he is involved in harassment and
interest statement. his profile: neutral, victim, aggressor or both; aggressor / victim.
Results.– Our sample was predominantly female (73,3%) and the
mean age was 21.73 ± 1,92. The majority of students (91%) live
E-PV0115 in urban areas.11,1% had high socio-economic level. Two thirds of
Incoherence in attitudes and our students fathers had a high level of education. 4.4% consumed
cannabis and 22.2% practice sport regularly. 75.6% of our students
representations of self, adults and
were neutral while 13.3% were victims, 6.7% were both abusers and
peers in adolescents with eating victims and only 4.4% were abusers. We found that bullying profile
disorders was significantly associated with gender (p = 0.010) and cannabis
A. Ryzhov1* , E.T. Sokolova1 , L. Pechnikova1 , A. Tkhostov1 , A.P. consumption (p = 0.014). However, their was no significant asso-
Zaharova2 , A.A. Korneev1 ciation between the harassment profile of our students and sport
1 Lomonosov MSU, Psychology, Moscow, Russia; 2 Research Centre of
activity, the level of study of their fathers or the socio economic
Eating Behaviour Disorders, Stationary Department, Moscow, Russia class.
Conclusions.– Several factors seem to be associated with the harass-
ment profile of our students. It would be useful to discern them
Background and aims.– Body-image and self-concept distortions,
in order to understand this growing phenomenon among our
reliance on social ideals are related to the struggle for autonomy
teenagers.
from parental figures in eating disorders and the reduction of inco-
herence of representations could be an important intervention
interest statement.
target.
Objectives.– To compare incoherence manifestations in represen-
tations and attitudes of self, parental figures and peers in patients E-PV0117
with eating disorders.
Methods.– Complementary measures of incoherence in representa-
Transition from child to adult mental
tions and attitudes were used: a modified repertory grid technique health services
with assessment of mean distances between self-aspects, adults C. Sanahuja Muñoz* , C. Sanchez Novella, A. Rodriguez Quiroga, L.
and peers elements; “Splitting Index” questionnaire (Gould et al., De Anta, M. Diez del Corral Belda, F.J. Quintero Gutierrez del Alamo
1996), adapted version of Affective scale for TAT (Thomas, 2008). Hospital Infanta Leonor, Mental Health Service, Madrid, Spain
23 impatient adolescent girls with eating disorders participated;
Splitting Index scores were compared with a control group of 54
Background and aims.– Adolescence is a period in which many
adolescents.
psychiatric disorders are developed. When they reach this age
boundary they are transferred from child to adult mental health E-PV0119
services, generally enduring a disruption not only in the follow-up Depressed adolescent inpatients have
but also in the approach of their symptoms. Our aim is to produce
more family adversities, negative
a literature review about this transition process.
Methods.– We conducted a bibliographic search through med-
self-image, less mature defenses and
line, pubmed, psycinfo and google scholar with the following less perceived social support than
key words transition, adulthood, adolescents, mental health peers with no psychiatric disorder
services. E. Savilahti* , M. Rytilä-Manninen, H. Haravuori, M. Marttunen
Results.– We found a description of diverse issues related to the Helsinki University Hospital, Adolescent Psychiatry, Helsinki, Finland
transition between these two vital periods. Many studies agree that * Corresponding author.
it is very important to achieve an optimal transition, in which there

is adequate planning, collaboration and communication among the Background and aims.– Background: Depression in adolescence is
teams and continuity of care after it. associated with several family related and psychological factors,
Conclusions.– It is essential to develop specific transition programs and life events.
for adolescents and young adults with mental health issues, with a Objective: To find out how adolescent psychiatric inpatients with
specialized approach to this period’s needs. depression differ from peers without psychiatric disorders and
Disclosure of interest.– The authors have not supplied a conflict of from adolescent psychiatric inpatients with other diagnoses.
interest statement. Methods.– Methods: The psychiatric diagnostics in the study pop-
ulation of 206 inpatients (13–17 years old) and 203 age and
gender matched non-referred adolescents was based on K-SADS-PL
E-PV0118 interview, and clinical interview and clinical records when avail-
A child and adolescent psychiatry able. Self-reports provided information on depression symptoms
(BDI-21), alcohol use (AUDIT), defense styles (DSQ-40), self-image
intervention in sports - a case report (OSIQ-R), perceived social support (PSSS-R) and on adverse life
from a preadolescent girl events. We compared firstly subjects with current unipolar depres-
P. Santos* , S. Pedroso sion (n = 120) to subjects without any psychiatric disorder (n = 159)
Centro Hospitalar e Universitário de Coimbra, Child and Adolescent and secondly within the inpatient population those with unipolar
Psychiatry, Coimbra, Portugal depression (n = 117) to those with any other psychiatric diagnoses
(n = 89).
Results.– Results: Current unipolar depression in comparison to
Background and aims.– Sports Psychiatry aims to diagnose and treat
both subjects without psychiatric diagnosis and inpatients with
psychiatric illness in athletes and to deliver psychological inter-
other diagnoses was associated with worse self-image, less mature
ventions to enhance performance. In youth sports, developmental
defenses and less perceived social support from the family. Adver-
processes to reach full sports potential are preferable over imme-
sities in the family were more prevalent in subjects with depression
diate performance. Sports Psychiatry for children must address
compared to subjects without any psychiatric diagnosis, while
children’s wellbeing in sports participation and to empower them
inpatients with other diagnoses faced even more family difficul-
with psychological skills for life.
ties. Psychiatric comorbidity was as prevalent in inpatients with or
To show the impact of psychiatric illness in sports performance and
without current depression, whereas suicidality was more common
to highlight how sports-directed psychological interventions have
among inpatients with depression.
impact in other life dimensions.
Conclusions.– Conclusions: Negative self-image, less mature
Methods.– Narrative review of the literature and presentation of a
defense styles and the wellbeing and communication within the
clinical case.
family should be addressed in the treatment of depression in ado-
Results.– The sport psychiatry diagnostic interview must take into
lescents.
account the demands of the specific sport setting and the stresses
of competition. Data from anxiety disorders on athletes are scarce.
interest statement.
State anxiety is normal before competitions and variability exists
regarding optimum intensity for an athlete’s performance. It was
hypothesized that social anxiety is an example of a psychiatric con- E-PV0120
dition in which symptoms are exacerbated by sports itself. Social
anxiety symptoms do not correlate to the level of competition. Alcoholic fetal syndrome as obligatory
Herein, we present the case of an 11-year-old girl diagnosed with part of lecture on prevention of
social anxiety. Gymnastics related activities were the most affected alcohol use of module “fundamentals
by symptoms. The girl underwent an 8 session’s sport psychia- healthy lifestyle” for students of
try intervention. The intervention included self-regulatory skills,
humanitarian and technical
cognitive restructuring, exposure exercises and mental visualiza-
tion. The following outcomes were observed: higher enjoyment of universities
training sessions, higher competition participation and rankings, L. Shapovalova1* , K. Shapovalov2
1 State Autonomous Health Agency of the Republic of Komi
increased academic performance and progressive daily life auton-
omy. “Consultative and Diagnostic Center of the Republic of Komi”,
Conclusions.– Psychiatric illness and sports activity interrela- Consultative department, Syktyvkar, Russia; 2 State Education
tionship is bidirectional. Diagnosis and treatment must account Agency of Additional Professional Education of Republic of Komi
sport-specific issues. “Komi Republican Institute for Development of Education”, Chair of
Disclosure of interest.– The authors have not supplied a conflict of Additional Education, Syktyvkar, Russia
interest statement.
Background and aims.– Social, family and personal effects of alco-
holic fetus syndrome (AFS) make it necessary to discuss it as
obligatory part when reading lecture “Preventing the use of alco-
holic beverages” in student and youth audiences.
Elimination of family alcoholic traditions in planning, conception, Disclosure of interest.– The authors have not supplied a conflict of
bearing pregnancy, breastfeeding and nurturing newborns. interest statement.
Methods.– Didactics.
Results.– Each reception by the future mother of alcohol at any stage
of pregnancy is a poisoning of the developing life of her child. Clin- E-PV0122
ical signs of AFS are: 1) Dysfunction of nutrition and metabolism in Psychiatric manifestations in
fetus; 2) Violations of the structure of skull; 3) Malformations and auto-immune diseases: a case report
deformities; 4) Damage to brain, including violations of intellec- A. Taamallah1* , S. Taleb2 , H. Ben mustapha2 , Z. Abbes3 , S.
tual development. Such children, often lag behind in development, Halayem4 , M. Hajri5 , A. Bouden6
can‘t study in a regular school, differ from peers with restless- 1 Resident, Child and Adolescent Department/ Razi Hospital,
ness, excessive mobility (and sometimes, on the contrary, lethargy Manouba, Tunisia; 2 Resident, Child and Adolescent Department/Razi
and apathy) and poor controllability. Among the frequent conse- Hospital, Manouba, Tunisia; 3 Doctor, Child and Adolescent
quences are convulsive seizures with the subsequent development Department Razi Hospital, Manouba, Tunisia; 4 Doctor, Child and
of epitheliotic disease. Adolescent Department, Manouba, Tunisia; 5 Doctor, Child and
Conclusions.– The use of alcohol by parents and, especially, by Children Department Razi Hospital, Manouba, Tunisia; 6 Professor,
women leads to a violation of the genetic apparatus of the future Child ans Adolescent Depatment Razi Hospital, Manouba, Tunisia
child and the hereditary transmission of acquired pathological fea- * Corresponding author.
tures. During pregnancy, alcohol consumption disrupts the course
of physiological changes in the woman’s body, which ensure the Background and aims.– Autoimmune diseases have a chronic evolu-
correct development of the fetus. The first, mild degree of AFS tion. Patients with chronic condition suffer from depression and/or
is characterized mainly by the child’s lag in physical develop- anxiety. The relationshipbetween depression and immunity has
ment (89.0%) and microcephaly with brain underdevelopment and been widely discussed but few studies have treated anxious symp-
mental retardation (84.0%). In the second and third stages of AFS, toms and behavior change. The aim of our work is to discuss the
numerous physical defects and deformities are attached to them, link between autoimmune diseases and psychiatric manifestations,
as well as variety of mental pathologies. with a review of the current literature.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– A case report discussed with a literature review, based
interest statement. in Pubmed, using « autoimmunediseases » « depression » « anxiety
» « immunity » « psychiatric manifestations » as key words.
Results.– Female 14 years old college student, without personal
E-PV0121 or familial history of psychiatric or auto-immune diseases. Two
Recognition of facial emotions test years ago, a partial epilepsy was diagnosed, unbalanced despite
among tunisian children: a pilot study the changing of antiepileptic medication. The patient was referred
A. Taamallah1* , S. Halayem2 , Z. Abbes3 , M. Hajri4 , A. Bouden5 to child and adolescent psychiatry department for drug suicide
1 Resident, Child and Adolescent Department/ Razi Hospital, attempt. Three months ago, she becamesad, cried easily, had
Manouba, Tunisia; 2 Doctor, Child and Adolescent Departement/ Razi headaches, lost interest in the daily activities, presented heart
Hospital, Manouba, Tunisia; 3 Doctor, Child and Adolescent palpitations and disturbance in sleep and appetite. The symp-
Department/Razi Hospital, Manouba, Tunisia; 4 Doctor, Child and toms were gradually worsening. She was sad and anxious. She
Adolescent Department/ Razi Hospital, Manouba, Tunisia; 5 Professor, had anhedonia, suicidal ideation, low self-esteem and insomnia.
Child and Adolescent Department/Razi Hospital, Manouba, Tunisia Shepresented headache and hand tremor. After a year of follow
* Corresponding author. up, only the depressive have improved. Six months later, she
was diagnosed with autoimmune pancreatitis and epilepsy and a
Background and aims.– Facial emotions’ recognition is an essential treatement with prednisone 40 mg/day was started. Currently, she
social skill. It enables to detect another person’s emotional status takes 5 mg/day. The depressive symptoms disapeared. The psycha-
and reaction, to respond appropriately in different social situations. tric examination reveal anxious symptoms, evoking social anxiety
A new tool adapted to Tunisian children has been developed to disorder.
explore the development of facial emotions’ recognition. Conclusions.– Distinction between psychiatric manifestations of
The aim is to validate the test in children from 7 to 12 years old, in autoimmune disease and comorbidity remains difficult. It requires
order to establish normative references. a knowledge of the symptoms’ chronology and a long-term follow-
Methods.– The test is composed of photographs and videos, up.
performed by six amateur actors of different ages and gender, rep- Disclosure of interest.– The authors have not supplied a conflict of
resenting the six basic emotions (joy, sadness, fear, disgust, anger interest statement.
and surprise) and neutrality.
It contains 114 photographs (19 per actor). Three photographs of
increasing intensity, for the same actor, represent each emotion. E-PV0123
36 videos were edited, with a maximal duration of five minutes. Management of hypersomnia in child
Data was presented to the medical staff for a first selection. Final psychiatry: a case report
selection was based on The Facial Action Coding System. R. Khemakhem, M. Hajri, A. Taamallah* , Z. Abbes, S. Halayem, A.
We conducted a pilot study, in order to initiate subsequently the Bouden
validation. Razi Hospital, Child and Adolescent Psychiatry, Manouba, Tunisia
Results.– Sixteen children were included. Seven of them were male * Corresponding author.
(44%), and nine were female (56%). The average age was 9 years.
The average rate of correct answers was 78 out of 114 (68–96/114). Background and aims.– Daytime sleepiness is a common subjective
Age was significantly correlated to the number of correct answers experience: 17 to 21% of school-age children suffer from it.
(p = 0.035). The recognition of fear and neutrality was also signifi- To illustrate the diagnosis and therapeutic difficulties faced by the
cantly correlated to the age (p = 0.01; p = 0.03). Gender didn’t appear child psychiatrist with excessive daytime sleepiness.
to affect the recogniton’s ability among participants. The emotions’ Methods.– Illustration by a case report then review of the literature
recognition was higher for videos than in photographs. by research carried out on the Pubmed and Sciencedirect databases
Conclusions.– the preliminary results are encouraging and they will using the following key words “excessive daytime hypersomnia”,
be discussed according to the results of the literature.
“narcolepsy”, “central hypersomnia” and “idiopathic hypersom- E-PV0125

nia”. Association between polymorphisms
Results.– M F, 8 years-old with normal psychomotor and language in oxtr and avpr 1a genes and social
developments, had recurrent depressive episods in mother’s his-
tory and an encephalopathy in the younger brother. She presented
deficits in autism spectrum disorder
K.M. Wilczyński1,2* , M. Janas-Kozik1,2
excessive daytime sleepiness (EDS) since the age of 4. It hinders 1 Medical University of Silesia, Deparment of Psychiatry and
learning and family interactions. She slept 14 to 15 hours at day
Psychotherapy of Developmental Age, Sosnowiec, Poland; 2 Pediatric
(12 hours of nocturnal sleep and 2 to 3 hours of nap) to which are
added frequent daytime sleep in class noted during moments of Centre of John Paul II in Sosnowiec Sp.zo.o, Sosnowiec, Poland
monotony. Episodes of cataplexy unrelated to strong emotions are
inconsistently associated with it. Note the absence of nocturnal Background and aims.– One of the defining features of autism
sleep disorders, automatic behaviors, hallucinations (hypnagogic or spectrum disorder (ASD) are deficits in social interaction and com-
hypnopompic) or sleep paralysis. We noted in our psychiatric exam munication. Although their etiology is poorly understood, several
an eutrophic girl, immature emotionally and with moderate psy- lines of evidence from studies on humans and rodents suggest that
chomotor instability. Different explorations (EEG, brain MRI, Holter neuropeptides such as oxytocine and vasopressine might play a
monitoring) did not reveal any abnormalities. A Multiple Sleep crucial role in their development. Single nucleotide polymorphisms
Latency Test (MSLT) confirmed the excessive daytime sleepiness. of the oxytocine and vasopressine receptors genes have been tested
We diagnosed a central diurnal hypersomnia. But is it narcolepsy for correlations with social cognition deficits in course of ASD in
or idiopathic diurnal hypersomnia? We have provided parental various populations, yielding contradictory results.
guidance and we discuss the methylphenidate’s use. Methods.– We have conducted a systematic review of literature,
Conclusions.– Despite advances in understanding the pathophysiol- published between january 2003 and august 2018, on associa-
ogy of central hypersomnia, there is currently no specific treatment. tions of single nucleotide polymorphisms in oxytocynergic and
Disclosure of interest.– The authors have not supplied a conflict of vasopressynergic systems with social cognition in ASD. Litera-
interest statement. ture search was performed with utilization of MEDLINE/PubMed,
Cochrane Library and APA psycNET databases, as well as Google
Scholar search engine.
E-PV0124
Results.– The review yielded 29 original publications, in most of
A systematic review of autism them association between social cognition deficits in ASD and
spectrum in children and adolescents single nucleotide polymorphisms in oxytocine and vasopressin
with 22q11.DS: prevalence, clinical receptor genes was statistically significant (p < 0.05).
significance and relationship with Conclusions.– Our findings seem to support the hypothesis that
single nucleotide polymorphisms in oxytocynergic and vaso-
onset of psychotic symptoms pressynergic systems may be associated with social cognition
M. Pontillo, S. Guerrera, R. Averna, F. Demaria, P. Gargiullo, M.C.
deficits in ASD. Most studies presented statistically significant cor-
Tata* , O. Santonastaso, S. Vicari
relations between various single nucleotide polymorphisms and
Paediatric Hospital Bambino Gesù, Department of Neuroscience -
features of ASD, however different authors pointed out different
Child Neuropsychiatry, Rome, Italy
* Corresponding author. polymorphisms, frequently contradicting preceding reports. This
may be caused by significant heterogenity of study groups between
Background and aims.– 22q11.2 deletion syndrome (22q11DS) is publications, which were recruited across mainfold ethnicities and
a genetic syndrome associated with different neurodevelopmental age groups, as well as lack of gender stratification in all analyzed
and psychiatric disorders. Several studies reported contrasting data reports.
about prevalence of autism spectrum disorder (ASD) in 22q11DS. Disclosure of interest.– The authors have not supplied a conflict of
Aim of our review was to summarize the evidence in literature interest statement.
on the prevalence and clinical significance of autism spectrum
disorders (ASD) in children and adolescents with 22q11DS. Sub-
E-PV0126
sequently, we also investigate the association between autism
spectrum disorders and onset of psychotic symptoms in this clinical Psychological problems of the child’s
population. family with autism
Methods.– A systematic review of the literature published from V. Zakharevich1* , T. Dakukina1 , A. Martynenka1 , S. Hreben2 , S.
1970 to March 2018 was conducted. Nine studies are included. Marchuk1
Results.– Four of nine studies included reported elevated (10-40%) 1 Republican Scientific-Practical Center of Mental Health, Deparment
rates of autism spectrum disorders, including autism. However, in of Mental and Behavioral Disorders- Section Science, Minsk, Belarus;
these studies the use of only parental report, not associated with the 2 Republican Scientific and Practical Center of Otolaryngology,
clinical direct observation, tends to overestimate the prevalence of Psychoneurological Department for Children, Minsk, Belarus
ASD in children and adolescents with 22q11DS. Studies included on * Corresponding author.
the relationship between ASD and psychosis in 22q11DS showed

that early childhood autistic features (both ASD diagnosis and only Background and aims.–
presence of autistic symptoms) are not predictive of subsequent Introduction.– In the family and society, the issues of socializing
onset of psychotic symptoms. children with autism are urgent. In such families are important the
Conclusions.– Based on findings of this review, ASD-like behaviors psychological climate. With the advent of the diagnosis of “autism”,
are present in children and adolescents with 22q11DS and they are the parents of the child may experience fear and anxiety. There are
similar at the symptom level of idiophatic ASD. However, the social conflicts in families.
impairments in 22q11DS and idiophatic ASD could be expression of Objectives.– to study the peculiarities of parent-child relations.
different neuropsychiatric picture. This should be considered in the Methods.– Psychological diagnostics using the method “Portrait of
planning of the treatment of the social impairments of 22q11DS. my child”.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The study involved full families of autistic children: 17
interest statement. mothers and 17 fathers. Analysis of the data showed: 60% of moth-
ers and 43% of dads feel sympathy and respect for their child
- the rest are dislikes and disrespect; 50% of mothers and 14% E-PV0128
of dads show closeness to their child, and the remaining ones Cognitive defect in children with
are remote from him. In relation to their child, parents experi-
endogenous mental illnesses
ence feelings of shame, anger, sometimes joy and empathy. In the
N. Zvereva1* , S. Strogova2
essay, parents share their inner state, describe the most complete 1 FBSI MHRC- MSUPE, Clinical Psychology, Moscow, Russia; 2 Mental
picture of the child’s personality. Parents do not include psycho-
Health Research Center, Department of Clinical Psychology, Moscow,
logical protection, which is a real diagnostic information for the
Russia
researcher. * Corresponding author.
Conclusions.– An analysis of the results of the methodology makes
it possible to follow the development of the child at home and in Background and aims.– Researching of the cognitive defect among
the community. In 2012 year in the Center there was a School for children and adolescents with endogenous mental illnesses
parents. Specialists trained parents correctly treat a child, teach (schizophrenia spectrum, severe forms - SS) as a basic viola-
communication skills. After a year in these families is more often tion related to this pathology demands analysis and psychological
noted the positive dynamics in the clinical picture of the child’s verification (lagging behind normative adolescents, special age
development. dynamics).
Disclosure of interest.– The authors have not supplied a conflict of Aim.– Estimation of emerging (formed) cognitive defect among
interest statement. children and adolescents with SS using the psychometric method
an d taking into account the age of onset of the disease and sex of
patients.
E-PV0127 Methods.– 74 (22 girls) children and adolescents with SS (avg = 11
Clinical and psychological evaluation y.o.) were observed. Assessment was carried out by psychometric
of children and adolescents with test WISC2 during the period of stability of the patient’s condition.
obsessive-compulsive disorders We use a special scale for cognitive defect assessment according to
N. Zvereva1* , T. Blinova2 , E. Balakireva2 , M. Zvereva3 , N. results of WISC.
Simashkova2 Results.– According to research data, we found 31 patients with
1 Mental Health Research Center- MSUPE, Department of Clinical reduced intelligence that is cognitive defect (IQ < 70) It is important
Psychology, Moscow, Russia; 2 Mental Health Research Center, that 21 of them have very early onset of the disease near 3 years.
Department of Child Psychiatry, Moscow, Russia; 3 Mental Health We obtained two groups. First “total cognitive defect” - 14 patients
Research Center, Department of Clinical Psychology, Moscow, Russia (11 boys, 3 girls) have a total low intelligence and it is impossible to
* Corresponding author. calculate the total score. Second; “partial cognitive defect”- 17 sub-
jects (12 boys, 5 girls) have an intellectual decline in combination
Background and aims.– Systematics of obsessive-compulsive dis- with uneven productivity of the accomplishing tasks of the test.
orders of childhood is one of the important problems in the Conclusions.– Age of onset of the disease has a significant impor-
developmental psychopathology. We don’t know too much about tance for children with SS in case of the formation of a cognitive
the difference between children with autistic and schizoty- defect of total type (the sooner disease begins, the more severe tde-
pal spectrum. It concerns clinical and psychological assessment. fect). Partial cognitive defect is more often observed in girls with
This investigation is a pilot one in the field of differential SS.
diagnostics. Disclosure of interest.– The authors have not supplied a conflict of
Aim.– Assessment clinical and psychological area of patients interest statement.
with obsessive-compulsive disorders in child psychiatric
hospital
Methods.– 22 patients (16 males) 4–15 years old with schizotypal
(F21), and autistic spectrum disorder - ASD (F84) were observed E-Poster Viewing - 7–9 April: Classification of
during hospitalization in child psychiatric clinic of MHRC. Mean mental disorders
age was 9.9 ± 4.9 years. Children & adolescents were assessed by
doctors and clinical psychologists. We use brief assessment accord-
ing to psychologist conclusion concerned cognitive and personality E-PV0129
state (0-3 points in 4 intellectual domain and 4 personality domain, Mental health and psychotropic drugs
common score). use within frames of
Results.– Patients were divorced to groups: children up to 8,5 -CG
and adolescents upper then 11,5 years - AG There was difference
bio-psychological approach in
between patients. In clinical symptoms: CG -patients with ASD outpatients in Azerbaijan
(F84) demonstrate obsessive movements; and AG – patients with A. Rasulov1 , R. Aliyeva2* , K. Talibova3 , A. Zeynalova4 , G. Aliyeva3 ,
schizotypal (F21)demonstrate motor-ideator disturbances. In psy- F. Ismayilov5
1 Azerbaijan State Advanced Training for Doctors naimed after A.
chological assessment: common score in CG (13,4) is larger than
in AG (9). We have found dissociation between intellectual and Aliyev, Psychiatry, Baku, Azerbaijan; 2 National Mental Health
personality domain in CG and haven’t found it in AG. Center, Psychosocial Rehabilitation Department, Baku, Azerbaijan; 3
Conclusions.– Pilot investigation children and adolescents with National Mental Health Center, Crisis Unit, Baku, Azerbaijan; 4
obsessive-compulsive disorders show the difference in clinical National Mental Health Center, Daycare Unit, Baku, Azerbaijan; 5
symptoms and psychological evaluation children with this dis- National Mental Health Center, Administration, Baku, Azerbaijan
orders suffering from autism and schizotypal. Next stage will be
sample expansion and analyzing clinical factors (diagnosis, age of
Background and aims.– Antipsychotic drugs have a broad range of
onset etc.)
use in the treatment of mental disorders in the acute stage of illness
as well as in support therapy. In this regard, there is a significant
interest statement.
requirement in the prescription of antipsychotics in accordance to
principles of rational use of medicaments. Despite the relevance of
this matter, the feature of psychotropic drug prescription in outpa-
tients in Azerbaijan has not been studied until now. The aim of the
study was to investigate the use of antipsychotic drugs in outpa- E-PV0131

tient practice and define the factors influencing dose selection of Multiple chemical hypersensitivity:
medicaments and polypharmacy use.
psychiatric disorder or not?
Methods.– Overall, 253 patients with different mental disorders
R. De La Mata Hidalgo1* , I. Valriberas1 , S. Gamonal1 , A. Bullón1 , G.
who were on outpatient treatment at the National Mental Health
Anmella2 , C. Martín3 , J. Matías4 , C. Lorenzo5 , A. R. Gude6 , J. de la
Center participated in the study. Analyzed variables included
Iglesia7
sociodemographic characteristics, clinical data and also informa- 1 Neurociencias, Psychiatry, Salamanca, Spain; 2 Hospital Clinic,
tion on prescribed treatment.
Unidad de Hospitalización Breve, Barcelona, Spain; 3 Neurociencias,
Results.– Neither sociodemographic nor clinical factors were show-
Unidad de Hospitalización Breve, Salamanca, Spain; 4 Neurociencias,
ing significant influence on the selection of medicaments. An
Unidad Hospitalización Breve. Psychiatry, Salamanca, Spain; 5
overwhelming majority of outpatients were treated with atypi-
Neurociencias, Unidad de Hospitalización Breve. Psichiatry,
cal antipsychotics, of which risperidone has been frequently used.
Salamanca, Spain; 6 Medicina Interna, Medicina Interna, Salamanca,
Doses of medicaments were lower than recommended ones and
Spain; 7 Ibsal, Psychiatry, Salamanca, Spain
only in the treatment of 3.2% of patients doses were relatively * Corresponding author.
higher. Higher doses of medicaments were associated with the
diagnosis of “schizophrenia” and the use of polypharmacy. Mean- Background and aims.– The multiple chemical hypersensitivity syn-
while, polypharmacy was associated with the use of conventional drome (HQM) is defined as a disease that can appear after exposure
neuroleptics. to toxic products. In recent years, there have been growing cases
Conclusions.– The present findings suggest that treatment in out- diagnosed in Spain in different private centers.
patient frame provides wide opportunities for rational use of Backgrounds.– Diagnosis of Hashimoto thyroiditis. Secondary gen-
antipsychotic drugs and considerably allows personalize the phar- eralized osteopenia.
macotherapy. The objective of the study is to assess if we have a new emerging
Disclosure of interest.– The authors have not supplied a conflict of psychiatric disorder, through a differential diagnosis with delu-
interest statement. sional disorder, somatization disorder and factitious disorder and
a literature review about this disease.
Methods.– A 66-year-old woman who has been lying in a bed
E-PV0130 for 3 years, socially isolated and dependent for activities of daily
Mathematical modeling and living. The patient refers to different symptomatic treatments with-
optimization of the pathogenic out success for years. Presents special measures for their disease
mechanisms of the destruction of as organic foods, can not use chemicals such as soap, detergent,
colognes, or electrical appliances such as television or radio and
myelin sheaths in multiple sclerosis windows and doors are sealed with insulators.
Q.A. Chaudhry
Results.– The evolution of the case after admission in a short hos-
University of Engineering and Technology- Lahore, Mathematics,
pitalization unit of psychiatry and the initiation of treatment with
Lahore, Pakistan
* Corresponding author. antidepressants and antipsychotics is partially favorable with res-
olution the somatic illness.
Background and aims.– Multiple sclerosis (MS) is considered to be Conclusions.– More studies are needed to know about this disease.
most common autoimmune disease where the immune system of Disclosure of interest.– The authors have not supplied a conflict of
a body starts attacking the myelin sheaths leading to its destruc- interest statement.
tion. The result of which causes the signals not to be sent properly
to the brain, thus breaking down the nervous system. A model was
E-PV0132
earlier developed by Ekaterina K (2017) to test the hypothesis that
variability in course of MS is driven by pathogenic mechanisms Albanian public attitudes to mental
responsible for the disease, autoimmune attack on central ner- health
vous system (CNS) that leads to neuroaxonal degeneration, chronic A. Hashorva1* , T. Pengili2
inflammation, and remyelination. 1 Taulant Pengili, Neuroscience, Tirana, Albania; 2 UHC Mother
Methods.– The model was simulated numerically, where the data Teresa- Tirana, Neuroscience, Tirana, Albania
available in literature was used. The correct values of the physi- * Corresponding author.
cal parameters and rate constants are not only important for the
validation of the in-vitro data, but also necessary for the correct Background and aims.– To obtain a comprehensive view of attitudes
realization and implementation in pharmaceutical industry. At the to mental health among the Albanian adult population, ultimately
same time, it is extremely important for the optimum parameters, to give support to mental health awareness comparing. a) raising
especially for the biological problems, that they must be compatible the awareness of individuals of the mental health and wellbeing.
with the physical situation of the problem. b) increasing the public knowledge of mental health and problems
Results.– We studied the dynamics of the different parameters of the positively influencing attitudes and behaviors toward people with
model effecting on CNS. Among other parameters, remyelination mental health problems. c) encouraging people with mental health
rate, myelin loss and growth rate are of certain importance which problems to recognize the importance of seeking professional and
have been optimized here. For this purpose, we have proposed the social support and empowering them to take on responsibility for
global optimization technique. their therapy and treatment.
Conclusions.– Optimization technique not only provided the opti- Methods.– This survey and the questioner used for the data col-
mal parameters which provided a nice agreement of the results lection where partly based on survey used for the same purpose
with the experimental data available in the literature but at the by the Health Service Executive-Mental Health Ireland. Adults
same time this approach can be utilized for other biological prob- aged 18+, sample size 520, from 10 cities of the countries.
lems. September–December 2015.
Disclosure of interest.– The authors have not supplied a conflict of Results.– 8% of people studied reported to have personally expe-
interest statement. rienced a mental health problem. main sources of information
of mental health are television-radio programs and technol-
ogy. 75% of people studied that Anyone can experience mental
health problems and about 90% of them accept it that in our
society many stereotypes exist about people with mental health been published and the works on the 11th edition of the Interna-
problems. tional Classification of Diseases (ICD-11) are ongoing. Our research
Conclusions.– 30% of the respondents could successfully recog- aims to systematize the knowledge about the expectations of Polish
nize the symptoms of depression and only 15% of the symptoms psychiatrists regarding the upcoming changes.
of schizophrenia. 9 in 10 people think that people with mental Methods.– The author’s questionnaire was prepared. The questions
health problems should not be allowed to be employed in jobs regarded the respondents’ opinion on classification systems. 102
directly with people. More than one in 2 respondents think that psychiatrists were interviewed during a national psychiatric con-
people with mental health problems should not have the right to ference. Responses were collected and analyzed.
vote. Results.– All respondents take advantage of the ICD classifica-
Disclosure of interest.– The authors have not supplied a conflict of tion on a daily basis, 22.5% of them also use DSM. The majority
interest statement. of polish psychiatrists are interested in the development of ICD
11. Criteria for mood disorders and schizophrenia were consid-
ered as the most useful in the diagnostic process, whereas the
E-PV0133 least useful were criteria for anxiety, and somatoform disorders.
Old-new diagnostics Respondents support the replacement of older categories like:
J. Keleinikov “alcohol abuse” and “alcohol dependence” with “substance use
Mental Health Center- Sha’ar Menashe, Rehabilitation Department, disorder” in DSM-5. In general psychiatrists are satisfied with
Ashkelon, Israel the elimination of the traditional division of schizophrenia into
* Corresponding author. subtypes.
Conclusions.– Current revision of the ICD classification is important
Background and aims.– Personal and psychotic features are inter- to improve its clinical utility.
related. Aim: to clarify the diagnosis, taking this relationship into Disclosure of interest.– The authors have not supplied a conflict of
account, for adequate psychotherapy. interest statement.
Methods.– The Eysenck test, similar to the classifications of Hip-
pocrates, Jung, Pavlov, Kretschmer, was used. The Circle diagram
shows the severity of extraversion or introversion and neurotic sta- E-PV0135
bility or lability. The third scale, perpendicular to the two previous A metacognitive group-concept based
ones, is proposed - social phobia - sociophilia, which allows one to
on psychiatric network approach
obtain instead of a circle a ball in which each subject occupies his
S. Paulsen* , P. Greve
diagnostic niche.
Helios Klinikum Bad Saarow, Psychiatry, Bad Saarow, Germany
Results.– 84 patients (66 in Russia, 18 in Israel) were examined. * Corresponding author.
A typical case. N. was born in 1941. The family was in evacuation.
She got sick at the age of 19 after poisoning with carbon monoxide. Background and aims.– The network approach (Borsboom) is one of
Was hospitalized many times in Russia and Israel with diagnoses of the most discussed innovations in psychiatry. The benefits of the
“encephalopathy with dysphoria”, “manic-depressive psychosis”, implications were explored in a metacognitive group.
“affective form of schizophrenia”, “Borderlain Personality Disor- Objectives.– Explorative group, to find out helpful interventions and
der”, “Schizophrenia, Disorganized Type”. (Typical abundans of implications from the network approach to psychiatric symptoms.
contradictory diagnoses). Methods.– The network approach to psychiatric symptoms was
Hospitalized in 1994. in a state of acute psychomotor agitation and focused in a psychoeducative group with 5 outpatients. The group
dysphoria. was running over 6 sessions in 2018. The patients had to name
Prodromal period: a choleric temperament, a heavy childhood. their symptoms and to estimate the severity in a scale (1 to 10
Trigger: brain hypoxia. points). The effect of the psychoeducation was measured in a time-
“Ball”: a labile extraversion of social phobia (according to Hip- line (2 weeks before start, at the second and the last session). The
pocrates - a choleric temperament, according to Pavlov - a strong concept of the psychiatric network approach was explained to the
mobile unbalanced type) participants. Specific, helpful interventions, focusing on isolated
Diagnosis: Organic Personality Syndrome. symptoms were discriminated.
Conclusions.– The improvement of diagnosis is based on histori- Results.– Severity of specific symptoms was reduced during the
cal clinical experience, not on previous DCM. A modification of the measured timeline. Anxiety decreased for nearly all patients (about
Eysenck’s Circle is proposed. 1 to 5 points). Also related symptoms like social phobia and neg-
Literature.– H. Aysenck, The structure of human Personality. N-Y. ative cognitions decreased. Other symptoms stayed stable (e.g.
1947 I. sleep disorder, somatic symptoms). For all participants helpless-
J. Keleinikov, Naturalness of the spirit, artificiality of the soul and ness decreased. In the last sessions patients felt more competent to
we are in all this. Tel-Aviv, 2016 influence their symptoms in a positive way.
Disclosure of interest.– The authors have not supplied a conflict of Conclusions.– The network-approach of psychiatric symptoms can
interest statement. be used for metacognitive therapy, e.g. in a psychoeducative
group-concept. The approach tends to focus on specific helpful
interventions, which are individual and may reduce severity of
E-PV0134 focused and related symptoms. The approach seems to reduce help-
Psychiatrists’ opinion on mental lessness of psychiatric patients.
disorder classifications in Poland Disclosure of interest.– The authors have not supplied a conflict of
A. Dudek, M. Dec, M. Buras, K. Nowak, K. Krysta* interest statement.
Medical University of Silesia, Department of Rehabilitation
Psychiatry, Katowice, Poland
Background and aims.– The necessity for a fundamental revision

of the current versions of international classifications of diseases
is widely discussed in the community of psychiatrists. Clinicians
call for changes in specific diagnostic areas. DSM-5 has already
E-Poster Viewing - 7–9 April: Comorbidity - Dual highlighting substances induced psychoses, with particular
Pathologies emphasis on stimulants/amphetamine/methamphetamine and
cannabis/marijuana induced psychoses, schizophrenia-spectrum
disorder or schizophrenia.
Results.– There are many differences between these two substances
E-PV0136 regarding neurobiological processes, average latency periods
Borderline personality disorder and before developing psychosis, clinical features as compared to
comorbid addiction schizophrenia, risk of using drugs and developing psychosis and
T. Aladashvili* , O. Kukhianidze, N. Okribelashvili drugs use & development of schizophrenia.
Center for Mental Health and Prevention of Addiction, Adult Conclusions.– The comparative studies across substances and its
Psychiatry, Tbilisi, Georgia association with psychosis could shed further insight into the
* Corresponding author. development of psychotic features. The relative prominence of
paranoid features of ATS-induced psychosis could lead to further
Background and aims.– Borderline personality disorder is charac- insight into the study of this prototypical delusional system.
terized by dysregulation of emotions, interpersonal relationships, Disclosure of interest.– The authors have not supplied a conflict of
behaviors, thinking processes and unstable self-image. The rela- interest statement.
tionship between BPD and addiction is a very tight one. Those who
have BPD are more likely to engage in drug or alcohol consumption
as an attempt to escape from reality. The use of drugs and alcohol E-PV0138
aggravate some of the more dangerous symptoms of BPD. An interesting case of a post epileptic
Aim of study was to evaluate the percentage of comorbid addiction
among BPD patients and demonstrate prevailing alcohol or drug
psychotic episode:a case report
P. Argitis1* , A. Kourti1 , M. Poulou2 , K. Paschalidis3 , K. Charisiou4 , A.
abuse cases.
Karampas5 , C.M. Platsa1
Methods.– Screen the inpatients of “Center for Mental Health and 1 General Hospital Of Corfu, Psychiatric, Corfu, Greece; 2 General
Prevention of Addiction” (Tbilisi, Georgia) for BPD (F60.3 According
Hospital Of Kymi, Anesthesiologyst, Kymi, Greece; 3 Psychiatric
to ICD-10) and determine incidence of co-occurring addiction.
Hospital of Thessaloniki, Psychiatric, Thessaloniki, Greece; 4
Results.– 55 inpatients of our Center were diagnosed with Bor-
University Hospital Of Ioannina, Neurologist, Ioannina, Greece; 5
derline Personality Disorder since January 2018, 50 of them had
University Hospital of Ioannina, Psychiatric, Ioannina, Greece
co-occurring addiction. * Corresponding author.
Among comorbid cases, the following statistics were disclosed:
• 30% Patients with alcohol abuse only. Background and aims.– Epilepsy and multiple sclerosis comorbidity,
• 40% Patients with combined addiction (alcohol and drug). is a often mentioned condition in the international bibliography.
• 20% Patients with drug abuse only. 2–7% of patients suffering from temporal lobe epilepsy, also present
• 10% Patients with isolated cannabis abuse. psychotic symptomatology.
Conclusions.– Results show that 90.9% of BPD patients who Methods.– We present a Case of a 28-year-old patient without
were hospitalized had co-occurring addiction. Comorbid substance previous psychiatric symptoms, was addressed to our emergency
abuse causes worsening of patients’ symptoms and decompensa- department with persecutory delusions, delusions of reference
tion, leads to frequent hospitalization, makes the treatment process and auditory hallucinations. The person had a history of multiple
more difficult. High incidence of alcohol abuse among BPD patients sclerosis treated with Dimethylfumarate. The necessary labora-
in Georgia can be explained by specific ethnocultural relationship tory tests were conducted, with no specific pathologyconfirmed,
of our country with wine. As Georgia is considered to be the cradle followed by the tests required for a first psychotic episode. For
of wine, winemaking and drinking is often not seeing as a problem, the acutephase the patient was treated with olanzapine 20 mg
even when it becomes an everyday habit. and lorazepam 2.5 mg three timesdaily. The next day, the patient
Disclosure of interest.– The authors have not supplied a conflict of seemed to respond well in treatment, not presentingany signs
interest statement. of acute psychopathology. We did not perform a drug test, but
since thepatient confessed that he was using cannaboid, we sus-
pected that it might have been adrug-induced brief psychotic
E-PV0137 episode. Due to excessive sedation we decreased thebenzodi-
Psychosis and substances use; what do azepine dosage. After 8 hours, the patient appeared confused,
we know? agitated anddelusional. An one minute lasting complex focal
F.F. Alharbi epilepsy episode was observed, followed by the same symptoma-
King Abdulaziz Medical City, Mental Health Department, Riyadh, tology. The incidence reoccurred six times during an hour, taking
Saudi Arabia the form of nonconvulsive status epilepticus. Since no medica-
* Corresponding author. tion was effective for the seizures, the episode was addressed by
intubation.
Background and aims.– Results.– An MRI was performed which revealed a new active T2
Background.– Prospective studies clearly demonstrate a temporal lesion on the cortex of the temporal lobe. The patient was eventu-
relationship between exposure to substances and psychosis albeit ally stabilized with anti-epileptic medication, presenting no signs
more accurate details on causality remain to be assessed. of psychotic symptomatology for the following fifteen months.
Objective.– This review focus on cannabis and amphetamine-type Conclusions.– There is a need for extensive laboratory tests and
stimulant (ATS) because of their high prevalence. We reviewed each imaging assessment in first psychotic episodes, something that is
substance group and its association with the risk for psychosis, psy- often overlooked.
chosis and risk for substance use, age of onset of psychosis, and Disclosure of interest.– The authors have not supplied a conflict of
development of schizophrenia. interest statement.
Methods.– A systematic literature search was conducted
from 1980 to date in the following databases: MEDLINE,
PsycINFO and PubMed. Articles were included if they were
E-PV0139 Methods.– A literature search of the Science Direct database was

Assessment of aggression in done up to September 2018, restricted to English-language arti-
psychiatric patients diagnosed with cles, using terms related to duloxetine, depression, stress urinary
incontinence. Original articles, reviews and meta-analyses were
comorbid personality disorder included.
B. Batinic1* , E. Eric2 , T. Vukosavljevic-Gvozden3
1
Results.– European Association of Urology suggests to offer duloxe-
Faculty of Philosophy- Department of Psychology, Clinic of
tine in selected patients with symptoms of SUI when surgery is not
Psychiatry- Clinical Centre of Serbia, Belgrade, Serbia; 2 Clinical
indicated. In women and in men with SUI after prostate surgery,
Centre of Serbia, Clinic of Psychiatry, Belgrade, Serbia; 3 Faculty of
duloxetine 80 mg may be superior to placebo and improves quality
Philosophy, Department of Psychology, Belgrade, Serbia
of life. Nausea is the most common treatment adverse event, was
mostly experienced within the first few days and resolved within
Background and aims.– Aggression, both self-directed and directed 1 to 4 weeks. Depression can result from incontinence and also,
to others, leads to a high level of suffering, and self-destructive when it is already present, can influence adversely motivation to
and suicidal behavior, as well as interpersonal problems and social stay continent.
consequences. Our aim was to identify whether the presence of Conclusions.– A unique mechanism of action on rhabdosphincter
comorbid personality disorder in a sample of psychiatric patients contractility and documented improvement of the quality of life
correlates with a higher level of aggressive feelings and behavior. in patients with SUI suggest that patients with SUI and concomi-
Methods.– The study sample comprised 150 psychiatric patients, tant/threatening depression may gain from the treatment with
mean age of 37.87 years (SD = 10, 22, min = 18, max = 72), 62% duloxetine.
females (N = 93), and males 38% (N = 57). According to ICD-10 Disclosure of interest.– The authors have not supplied a conflict of
criteria, the patients were diagnosed by their psychiatrists as fol- interest statement.
lows: schizophrenia spectrum (42.1%), affective disorders (36.4%)
and anxiety disorders (21.4%). Twenty-four percent of the whole
E-PV0141
(n = 37) sample were also diagnosed with comorbid personality dis-
order. The Aggression Questionnaire, BPAQ (Buss & Perry, 1992) Comorbidity of obsessive compulsive
were applied to ascertain the total level of aggression, as well as symptoms and disorder with
Physical aggression, Verbal aggression, Anger and Hostility, accord- schizophrenia
ing to the 4-factors scale. W. Bouattour* , J. Ben Thabet, S. Njjar, M. Maalej Bouali, S. Omri, R.
Results.– Psychiatric patients diagnosed with comorbid personal- Feki, N. Zouari, L. Zouari, N. Charfi, M. Maalej
ity disorder compared with those without personality disorder University Hospital Center Hedi Chaker, Department of Psychiatry C,
displayed significantly higher total Aggression (p = 0.02), as well Sfax, Tunisia
as Physical aggression (p = 0.009), Verbal aggression (p = 0.05) and * Corresponding author.
Anger (p = 0.01), with the exception of Hostility (p = 0.9).
Conclusions.– Aggression should be a specific subject of existing Background and aims.– Co-occurrence of obsessive compulsive
therapeutic approaches for psychiatric patients with comorbid per- symptoms (OCS) and psychotic illness was first recognized over a
sonality disorder, in order to reduce feelings of anger and verbal and century ago. Interest in this area has been revived recently because
physical aggression and its emotional, physiological and behavioral of increased recognition of higher-than-expected comorbidity
negative consequences. rates. The aim was to study the comorbidity rate of obsessive com-
Disclosure of interest.– The authors have not supplied a conflict of pulsive disorder and obsessive compulsive symptoms in patients
interest statement. with schizophrenia and their relation with the course of this illness.
Methods.– Thirty-eight out-patients from university hospital cen-
ter Hedi Chaker Department of Psychiatry of Sfax (Tunisia)
E-PV0140 who met the DSM V criteria for schizophrenia were recruited
Stress urinary incontinence and for this study. Patients were out of acute exacerbation phase
of schizophrenia. Yale-Brown Obsessive-Compulsive Scale, Yale
depression – a place for duloxetine –
Brown Obsessive Compulsive Symptom Screening Inventory were
literature based analysis of efficacy applied to patients.
and safety of treatment Results.– The mean age was 41 years (range 19-65 years), with a
D. Berent1,2* , M. Skoneczny3 sex-ratio (M/F) of 6.6. The average age of onset of schizophrenia
1 Masovian Regional Hospital “Drewnica”, Adult Psychiatry, was 25.2 (range 15–34) and the duration of disease varies between
˛
Zabki/Warsaw, Poland; 2 PsychoMedic.pl, Adult Psychiatry, Warsaw, 1 and 35 years. Eight patients (21%) were taking atypical antipsy-
Poland; 3 Pirogow Regional Hospital in Łódź, Urology and Renal chotics. Comorbidity rate of obsessive-compulsive disorder (OCD)
Transplantology, Łódź, Poland in patients with schizophrenia was 10.53%, and OCS were detected
23.7% of patients. Aggressive and religious obsessions were seen
most frequently (15.8% and 13.2% respectively). OCS were reported
Background and aims.– Duloxetine, a serotonin and noradrenaline-
more frequently in patients having Global Assessment of Function-
reuptake inhibitor, increases rhabdosphincter contractility via the
ality score higher than 45 points (p = 0.031), and taking atypical
stimulation of pudendal motor neuron ␣-1 adrenergic and 5-
antipsychotics (p = 0.049).
hydroxytryptamine-2 receptors. Wide literature supports use of
Conclusions.– Our study has just shown that comorbid obsessive
duloxetine in patients with stress urinary incontinence (SUI).
compulsive symptoms in schizophrenia were frequent in our sam-
Patients with SUI are known to be at greater risk of depression
ple and were associated with the use of atypical antipsychotics.
than the general population. This is to analyse safety and efficacy
However, they had no major effect upon the course of this psychotic
of duloxetine treatment in patients with SUI and to shed light on the
illness.
subpopulation of patients with depression and SUI and/or patients
with SUI and threatening depression as a noteworthy treatment
interest statement.
target for duloxetine.
E-PV0142 Methods.– Literature review of published studies using the key-

Psychiatric comorbidity in patients words “autism” AND “depression” OR “grief”.
with posttraumatic stress disorder Results.– A young man with ASD presented with somatic com-
plaints and beliefs of having a fatal disease. He was first treated with
and enduring personality change after antipsychotic with no improvement. Further exploration revealed
catastrophic experience depressive symptoms following the loss of his grandmother. Treat-
L. Bradic1* , D. Begic2 , I. Lokmic-Pekic2 , A. Hrnjica3 , M. Ahmic4 ment with an antidepressant showed clinically improvement.
1 Psychiatric Hospital of Canton Sarajev, Men’s Psychatric Depression seems to be highly prevalent on ASD adults but mood
department, Sarajevo, Bosnia - Herzegovina; 2 Psychiatric Hospital of assessment mood and communication of inner experiences can
Canton Sarajevo, Intensive Care Unit, Sarajevo, Bosnia - Herzegovina; be challenging. Also, depressive symptoms may be frequently
3 Psychiatric Hospital of Canton Sarajevo, Woman’s Department,
over-shadowed by some caracteristical behaviour. The need for
Sarajevo, Bosnia - Herzegovina; 4 Psychiatric Hospital of Canton consulting an informant appears determinant to assess changes in
Sarajevo, Head of hospital, Sarajevo, Bosnia - Herzegovina these patients’ functioning.
Conclusions.– Depression seems frequently overlooked and condi-
tioned by the emotional disturbances of ASD.
Background and aims.– Post-Traumatic Stress Disorder (PTSD) is a
Psychiatrists should carefully consider each patient’s development,
trauma and stress related disorder that may develop after expo-
recent behavioural changes and objective signs of depression, thus
sure to an event in which death, severe physical harm or violence
minimizing risks of misdiagnosis and mistreatment. Studies focus-
occurred or was threatened (1). Enduring personality change after
ing on depression in adults with ASD are lacking.
catastrophic experience is characterized by personality changes
after a significant event or events. This condition may be preceded
interest statement.
by PTSD (2).
Aim of this research was to examine prevalence of psychiatric
comorbidity and to analyze sociodemographic characteristics in E-PV0144
patients with PTSD and enduring personality change after catas-
trophic experience.
Opioid use: an update and the
Methods.– This retrospective study included 20 patients that were situation of the opioid consumption
admitted in our hospital in one year with diagnosis of PTSD and in the unit of dual pathology and the
Enduring personality change after catastrophic event. unit of detoxification of salamanca,
Results.– Among all patient, there were 12 men and 8 women. There Spain
were 11 patients with PTSD diagnosis. Enduring personality change N.M. Casado Espada* , R. De Alarcón Gómez, J.I. De La Iglesia
after catastrophic experience diagnosis had 9 patients. Comorbid- Larrad, M.T. Lozano López, S.R. Gamonal Limcaoco, I. Valriberas
ity was present in 17 patients. The most common comorbidities Herrero, A. Bullón, A.I. Alvarez Navares, M.A. Garzón de Paz
in women were F 33.2 and F 32.1; in men F 10.2 and F 10.1. We University of Salamanca Health Care Complex, Psychiatry,
had 15 married patients. Twelve patients had high-school level of Salamanca, Spain
education. Unemployed were 7 women and 7 men. * Corresponding author.
Conclusions.– Results implied that in women with PTSD and Endur-
ing personality change after catastrophic experience diagnosis, the Background and aims.– The prescription of opiates has increased
most common comorbidities were depressive disorders, while in significantly. Moreover, the consumption of opiates and the num-
men were Mental and behavioral disorders due to use of alcohol. ber of deaths caused by an overdose from these substances has also
Analysis of sociodemographic characteristics demonstrated that increased.
unemployment was present in high percentage equally distributed Reviewing, collecting and presenting up-to-date information on a
among both sex, and that most of the patients were married. very important public health problem. Assessing the situation of
Disclosure of interest.– The authors have not supplied a conflict of the UDT AND UDP of Salamanca in the years 2016 to 2018 with
interest statement. regard to the consumption of opiates.
Methods.– Retrospective data collection from patients treated in the
years 2016 to 2018 in the Unit of Dual Pathology and the Unit of
E-PV0143 Detoxification of Salamanca. Literature review in the main search
Depression in adults with autism engines (PUBMED, COCHRANE).
spectrum disorders Results.– In our study, we collect, according to the literature review,
C. Bragança1* , F. Monteiro da Silva2 the role of the different substances in the opioid crisis and the pro-
1 Unidade Local de Saúde do Nordeste, Departamento de Psiquiatria e posals aimed at reducing the mortality rates as a consequence of
Saúde Mental, Bragança, Portugal; 2 Hospital Magalhães Lemos, opioid overdose. Moreover we show the situation of our region in
Departamento de Psiquiatria, Porto, Portugal the opioid crisis.
* Corresponding author. Conclusions.– FENTANYL has been suggested as one of the main
agents responsible for de opioid epidemics.
Background and aims.– Another fundamental factor is the new marked of drugs1 , whose
Introduction.– Autism Spectrum Disorders (ASD) are well-known characteristics help buyers and sellers alike and make it difficult
in child and adolescent psychiatry. However, these individuals are for public security forces to track them.
frequently missed upon their transition to adult psychiatry or either With regard to the situation of our region and the consumption of
underdiagnosed. First diagnosing ASD in adults may be difficult and opiates, according to the data collected and analyzed by the UDP
they may only seek psychiatric care when comorbidities arise - such and UDT of Salamanca in the years 2016-2018, we may conclude
as anxiety, affective or psychotic disorders. that there has also been an increase in the proportion of opiate
Focusing on depression, it can be challenging to clinicians to diag- users among the patients treated in our center, mainly associated
nose, as it is frequently based on the patient’s subjective experience to cases of consumption of methadone and to polydrug use.
and identified in the empathic therapeutic relationship. Disclosure of interest.– The authors have not supplied a conflict of
Objectives.– Presenting a case-report and reviewing the specificities interest statement.
of depression in adults with ASD.
E-PV0145 Basic studies revealed anemia (10,2 g/dl) and thyrotropic insuffi-
A behcet’s disease with a bipolar ciency (FT4 = 6,39 pmol/l; TSH = 1,77 uUI/ml). Initially, neuroleptic
mood disorder: a case report treatment did not improve psychotic symptoms until we corrected
A. Haouala1 , M. Guedria1 , N. Hamza1 , I. Chaari2* , R. Machraoui1 , S. biological disturbances especially thyrotropic insufficiency with
Younes1 thyroxin.
1 Taher Sfar Hospital, Neurology-Endocrinology Department, Mahdia, Conclusions.– The causal relationship between hypopituitarism and
Tunisia; 2 Fattouma Bourguiba University Hospital, Psychiatry psychosis is not clear. Prospective follow-up of patients with pitu-
Department, Monastir, Tunisia itary dysfunction would clarify prevalence rates.
interest statement.
Background and aims.– Behcet’s disease is a chronic, relaps-
ing multisystem-vascular-inflammatory disorder. Vasculitis is its
major pathological-feature. Psychiatric manifestations have been E-PV0147
described, not necessarily attributable to cerebral lesions. Low dose chlorprothixene
Methods.– We report a case of Behcet’s-syndrome, in which Bipolar- administration in patients with atopic
Disorder revealed during the first physical manifestations dermatitis
Results.– A 44-year-old right-handed male, with previously healthy I. Danilin1* , Z. Ziewozinska2 , I. Korsunskaya3 , M. Artemieva1 , R.
status, was admitted with complaints of acute, generalized Suleymanov1 , V. Sokolov1 , V. Karnozov1
headache associated with left-arm-and-leg weakness. He had 1 Peoples’ Friendship University of Russia RUDN University,
weakness, loss of appetite and a progressive worsening of commu- Department of Psychiatry and Medical Psychology, Moscow, Russia; 2
nication with family members for 3–4 days before the admission. Pirogov Russian National Research Medical University, Moscow
Physical examination revealed oral aphthous ulcers. A thorough Scientific-and-Practical Center for Dermatovenereology and
neurological examination revealed a quadripyramidal syndrome Cosmetology, Moscow, Russia; 3 Moscow Scientific and Practical
with predominant left motor deficit. Psychiatric interview showed Center of Dermatovenereology and Cosmetolog, Moscow Helthcare
a sad mood (HAD-D = 17), excessive anxiety (HAD-A = 12) and Department, Moscow, Russia
visual-hallucinations. The diagnosis of Behcet’s-disease was made * Corresponding author.
based on the presence of recurrent oral-aphthous ulcers, vascular-
involvement, a positive Pathergy-test and positive HLA-B51 in Background and aims.– Atopic dermatitis is a chronic skin disease,
the absence of evidence of other diseases. Since then, he was affecting up to 12% of population. Most scientists attribute atopic
treated with Methylprednisolone-pulses linked with a high-dose dermatitis to combine genetic, allergenic and emotional etiologic
regimen of prednisone during 2 months, daily Azathioprine, factors. There is definitely more than one trigger modality that
and physical rehabilitation was started. Psychiatric treatment can lead to the manifestation or exacerbation of symptoms. Psy-
included an antidepressant (escitalopram 10 mg/day) and an chogenic factors, often take a leading position in this index. Some
antipsychotic (risperidone 2 mg/day). Two years after discharge, personality traits may lead to instability of the emotional sphere
despite marked regression of physical impairment, he presented that can act alternately as a cause, then as an aftereffect of exac-
a depressive relapse followed by a manic episode induced by erbation of the chronic process, forming a kind of psychosomatic
tricyclic-antidepressant (amitriptyline 50 mg/day). He was diag- “vicious circle”, which requires exploration and treatment.
nosed with a Bipolar disorder type-I according to DSM IV-TR. Mood Methods.– Working together with dermatologist, we examined 30
stabilizer was introduced (Sodium-valproate 1500 mg/day). Dur- patients with diagnosis of atopic dermatitis. All patients under-
ing the following 6years he had two brief recurrent episodes in a went psychiatric interviewing and psychological testing (STAI). The
context of poor-therapeutic-compliance. results revealed increased trait anxiety levels among 23 of them
Conclusions.– This association was previously reported. Data sug- with moderate severity of the process according to SCORAD index.
gest a common neurobiological substrate at least in certain cases. Chlorprothixene in dosage of 7,5 to 15 mg. daily was added to the
That may present an attractive therapeutic target. common dermatologic therapy in this group.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Patients noted not only improvement of general condi-
interest statement. tion, reduction of anxiety, sleep improvement, but also much more
rapid and pronounced decrease of skin symptoms. 8 patients noted
a marked improvement even in the absence of a previous history
E-PV0146 of good remission.
Congenital hypopituitarism and Conclusions.– This modest result may aim further clinical research
psychosis symptoms: a case report on psychopharmacological treatment of some skin diseases in close
S. Smaoui1 , R. Damak1 , F. Cherif2* , F. Fekih Romdhane1 , W. Cherif1 , cooperation with dermatologists. Finding intercommunications in
S. Ellini1 , M. Cheour1 pathogenesis of skin and emotional disorders could significantly
1 Razi Hospital, Ibn Oumrane Psychiatry Department, la Manouba, optimize the treatment and enhance patient’s quality of life.
Tunisia; 2 Hedi Chaker University Hospital, Psychiatry “C” The publication was prepared with the support of the “RUDN Uni-
Department, Sfax, Tunisia versity Program 5-100”.
interest statement.
Background and aims.– The number of cases in the literature linking
psychosis to hypopituitarism is limited.
Methods.– We report a case of a 48 year-old female patient who was E-PV0148
referred to our department of psychiatry for psychotic symptoms. Determinants of quality of life among
Results.– The patient was followed since she was young for congeni- asthma workers
tal hypopituitarism, and genetics studies revealed mutation R73C in A. Fki1* , M. Hajjaji1 , W. Feki2 , N. Kotti1 , N. Kammoun1 , K. Jmal
PROP1 gene. She interrupted follow-up since 11 years but she kept Hammami1 , S. Kammoun2 , M.L. Masmoudi1
on medical treatment with only hydrocortisone. She was admit- 1 Hedi Chaker Hospital, Occupational Medicine, Sfax, Tunisia; 2 Hedi
ted to the psychiatry department because of behavioral disorder. Chaker Hospital, Pneumology, Sfax, Tunisia
She presented auditory hallucinations with delusional interpreta- * Corresponding author.
tion and persecution delirium which appeared since 18 months.
Background and aims.– Asthma is a common pathology in the work- integrate into their age group [3]. In this way they will better man-
place. The welfare of the asthmatic and the better control of the age their human interactions and increase their life quality.
disease have become a goal in the management to ensure satis- Disclosure of interest.– The authors have not supplied a conflict of
factory social and professional life the aims of this study was to interest statement.
evaluate the quality of life of asthmatic workers and to identify its
influencing factors.
Methods.– A descriptive cross-sectional study conducted among E-PV0150
active asthmatics patients followed in a Pneumology department Comorbidity of organic mental
in Tunisia. Sociodemographic, professional and clinical data were disorders and alcohol dependence
collected. The quality of life of these asthmatics was assessed by M. Gilenko* , V. Vandysh-Bubko
the SF12 scale in its physical and mental dimensions. 1 V.P. Serbsky National Medical Research Center for Psychiatry and
Results.– During the study period, 64 patients (mean age: 44.4 ± 9.5 Narcology, Department of Exogenous Mental Disorders, Moscow,
years, sex ratio: 0.72) were included. The overall mean score for Russia
quality of life was 55.3 ± 18.9 and 34.4% of asthmatics had a low * Corresponding author.
overall quality of life score. The overall quality of life score was cor-
related with the presence of a pollutant site near home (p = 0.007), Background and aims.– Forensic psychiatrists often observe the
the severity of asthma (p = 0,000), and the level of disease con- comorbidity of organic mental disorders and dependence on alco-
trol (p = 0.000). The physical health score was correlated with the hol. The clinic and dynamics of this comorbid pathology largely
severity of asthma (p = 0.01) and uncontrolled asthma (p = 0.000). depends on the sequence of the formation of mental disorders. The
Employees reporting a worsening of their symptomatology at work aim of this study was to determine the characteristics of comorbid
had a lower physical health score. The mental health score was diseases, depending on the sequence of disorders.
significantly associated with the severity of asthma (p = 0.001), Methods.– 302 men diagnosed with “Organic, including symp-
uncontrolled asthma (p = 0.000) and worsening asthma at work tomatic, psychiatric disorders” (F00-09 ICD-10) and “Alcohol
(p = 0.042). dependence syndrome” (F 10.2 ICD-10) were examined using
Conclusions.– Improved knowledge of the predictive factors of poor clinical-psychopathological and clinical-dynamic methods.
quality of life for asthmatic workers enables the introduction of Results.– Taking into account the sequence of the development of
targeted action to improve the quality of life of these employees. the disorders, two groups were identified: 1 group - organic men-
Disclosure of interest.– The authors have not supplied a conflict of tal disorders complicated by alcohol dependence (n = 194, 64.2%);
interest statement. Group 2 - dependence on alcohol with secondary comorbid organic
mental disorder (n = 108, 35.8%). In the first group young people
predominated up to 30 years old, with perinatal and traumatic brain
E-PV0149 lesions. Cognitive and behavioral disorders disrupted their social
Clinical aspects and therapeutic adaptation, leading to the early onset of alcohol use during ado-
approaches in bipolar disorder with lescence. Alcohol dependence was formed rapidly and weighted
the course of the primary organic mental disorder. In the second
pseudo-obsessional onset
group, men over 55 years of age predominated, who had alcohol
I.A. Georgescu1,2* , M.M. Let, i1 , M. Hăt, is, 1 , R. Grozăvescu1,3
1 dependence for many years, leading to trauma and early formation
Prof. Dr. Alexandru Obregia Clinical Psychiatry Hospital, Child and
of vascular pathology. As a result of the action of additional exoge-
Adolescent Psychiatry, Bucharest, Romania; 2 Carol Davila University
nous hazards, a secondary progressive organic mental disorder was
of Medicine and Pharmacy- Faculty of Medicine, Physiology and
formed in connection with mixed diseases.
Neuroscience, Bucharest, Romania; 3 Carol Davila University of
Conclusions.– Specific syndromokinesis and clinical dynamics for
Medicine and Pharmacy- Faculty of Medicine, Child and Adolescent
each group predetermine different approaches to diagnosis and
Psychiatry, Bucharest, Romania
* Corresponding author. forensic psychiatric evaluation, require different treatment and
rehabilitation tactics.
Background and aims.– Bipolar Disorder - Obsessive Compulsive Disclosure of interest.– The authors have not supplied a conflict of
Disorder comorbidity is frequent among adolescents, with a higher interest statement.
incidence than adults (23.2% versus 13.56%) [1]. However, there is
still no official protocol for treating patients with this kind of pathol-
ogy. Standard obsessive compulsive disorder treatment (SSRI) can E-PV0151
worsen bipolar disorder symptoms, turning to mania, therefore Hyperalgesia and opioids
mood stabilizers are most commonly administrated and, if the R. Hernández Antón1* , P. Datta2 , I. Isidro García3 , H. De la Red
patients are refractory to treatment, they can be associated with Gallego1 , C. Capella Messeguer1 , E. Rodríguez Vázquez1 , M. De
atypical antipsychotics (Risperidone, Quetiapine, Aripiprazole) [2]. Lorenzo Calzón1
1 Psiquiatría, Psiquiatría, Valladolid, Spain; 2 Politécnica de Torino,
The main purpose of our study was to analyse in detail the case of
a 16-year-old patient with this comorbidity, hospitalised at “Prof. Politécnica de Torino, Torino, Italy; 3 Psiquiatría, Psiquiatría,
Dr. Alexandru Obregia” Clinical Psychiatry Hospital in Bucharest. Santander, Spain
Methods.– The patient was psychologically assessed and the results
were correlated with his personal history. We examined the ther-
Background and aims.– Buprenorphine/Naloxone is a substitution
apeutic approach and the periods of remission in order to better
treatment for opioid dependence, within the framework of medi-
understand the pathology and increase the quality of his life.
cal, social and psychological treatment. The association of pain and
Results.– The particularity of the case is represented by the thera-
psychiatric disorders is frequent and it can increase the probability
peutic resistance of the disease, even though multiple intervention
of developing opioid use disorders.
schemes were tested. Also, even if the patient had an increased
Methods.– A 30-year-old male who resides with his mother. He
insight of the disease and was receptive to therapy, he still had
worked in the hotel industry. He has suffered of neuropathic
obsessive thoughts and felt insecure, which significantly reduced
pain caused by a Cervical pain after a car accident. He drinks
the quality of his life.
Alcohol and smokes tobacco since he was 15 years old. He smoked
Conclusions.– In conclusion, the pharmacological treatment should
cannabis from 16 to 25. Dependent on opiates over 10 years old,
be associated with cognitive-behavioral therapy, important
he tried a first detoxification with methadone 6 years ago, which
parental support and constant counselling to help these patients
he abandoned after a short time. He began to consume Tramadol Background and aims.– Premenstrual syndrome (PMS) is intimately
daily and heroin. A month ago, he relapsed into the consumption related to major depressive disorder (MDD). In DSM-5 premen-
of smoked heroin coinciding with a dismissal from work, to find strual dysphoric disorder (PMDD), a subtype of PMS, is even
himself more calm and to alleviate the pain. classified in the chapter Depressive disorders. Selective serotonin
Results.– We proposed the administration of Buprenor- re-uptake inhibitors (SSRIs) are treatment of choice in the man-
phine/Naloxone. One week before the induction, the dose of agement of PMS. Objectives: To examine the clinical symptoms of
Tramadol was reduced to 100 mg every 6 hours and the day before, PMS in women with current depressive episode before and after
we added the Olanzapine 2.5 mg/day. On initial days, treatment 6-month course of SSRI treatment.
with Buprenorphine/Naloxone was maintained at 4 mg/day, Methods.– Longitudinal interventional study on the clinical picture
without reporting “craving”. The dose was increased to 8 mg/day. of PMS and comorbid MDD before nd after 6-month SSRIs intake.
Conclusions.– Opioid-induced hyperalgesia is a paradoxical reaction We examined 31 women (mean age 39.4 ± 7.21) suffering from PMS
characterized by an increased perception of pain, related to the use and a current episode of MDD eligible to SSRI treatment. PMS and
of these drugs in the absence of progression of the disease or with- MDD were verified by means of PSST and MINI, respectively.
drawal syndrome; neuropathic pain is improved by buprenorphine Results.– According to our results the most prevalent symptoms in
by activating endogenous igando nociceptin/orphanin receptors, comorbid patients are mood lability, anxiety, fatigue (100%), irri-
at the spinal level; and hyperalgesia improves by modulation of tability and sleep changes (96.8%), breast tension and tenderness
calcium channels (100%), abdominal bloating (93.5%), headaches (93.1%). Psycholog-
Disclosure of interest.– The authors have not supplied a conflict of ical symptoms dominate the syndrome being around three times
interest statement. more common than somatic. PMS is mostly moderately severe.
After 6-month SSRI treatment a statistically significant (p < 0.001)
effect on both symptom types was noticeable, although certain
E-PV0152 somatic symptoms still persisted. At the end of the follow up severe
Acute intermittent porphyria in a cases were completely resolved and mild cases prevailed.
psychiatric patient – the wolf in Conclusions.– 1. PMS with comorbid MDD is dominated by mood
lability, fatigue, anxiety, breast tension and tenderness. 2. Psy-
sheep’s clothing: a case report and
chological symptoms prevail. 3. SSRIs are helpful in treating both
literature review symptom types, but still more pronouncedly psychological ones.
K. Hofert* , J. Baek Disclosure of interest.– The authors have not supplied a conflict of
Greater Manchester Mental Health NHS Trust, Psychiatry, interest statement.
Manchester, United Kingdom
E-PV0154
Background and aims.– Acute Intermittent Porphyria (AIP) is an
autosomal dominant disorder in the haem synthesis pathway. AIP Psychosocial disorders in patients
can have a variable presentation but psychiatric symptoms such with rheumatoid arthritis in Albania
as psychosis form part of the classical triad alongside abdominal M. Jordhani* , D. Ruci
pain and impaired cognitive function. The prevalence of AIP in psy- UHC Mother Teresa, Internal Medicine, Tirana, Albania
chiatric patients is higher than the typical population (Elder et al.,
2013).
Background and aims.– Because of chronic pain, disability and
Methods.– Here we report a case of psychiatric inpatient who pre-
long-term treatment, patients with rheumatoid arthritis (RA) are
sented with an acute attack of porphyria whose diagnosis of AIP was
susceptible to psycho-social disorders.
clouded by complex psychiatric co-morbidity. We also reviewed
The aim of this study is to evaluate the impact of psycho-social
the current literatures focusing on patient diagnosed with AIP in
disorders in patients with RA for more than 5 years.
the psychiatric health setting.
Methods.– This is an observational study which included 77 patients
Results.– Purely psychiatric manifestations of AIP are reported in
with RA for more than 5 years, presented at UHC “Mother Teresa”,
the literature (Ellencweig et al., 2006), but there is no current con-
Tirana, Albania. Forty-five females and 32 males were part of the
sensus on prevalence. This creates a clinical quagmire for patients
study. All patients where evaluated clinically and with laboratory
with pre-existing psychiatric conditions as this has the potential to
exams. In every patient was evaluated RA disease activity score
masque psychiatric symptoms of AIP.
and a psychiatric consult was performed to evaluate psycho-social
Conclusions.– This diagnostic difficulty may lead to under diagnosis
status.
of AIP. Therefore, we encourage consideration of AIP in the differen-
Results.– It was found that, of 77 patients, 54 patients (70.1%) were
tial diagnosis in any acute psychiatric presentation. Furthermore,
found with psycho-social issues concomitant to RA and 23 (29.9%)
by reviewing the literature we hope to shed light on the prevalence
were normal. Of 45 female patients, 24 (53.3%) were diagnosed with
of psychiatric manifestations of AIP.
general anxiety disorders (GAD), 12 (26.6%) with depression and 9
(20%) had no psycho-social disorder. Of 32 males, 12 (37%) had GAD,
interest statement.
6 (18.7%) depression and 14 (43.7%) were normal.
It was observed that 16 patients (20.7%) had low disease activity at
E-PV0153 the moment of evaluation, 28 (36.4%) had mild disease activity and
33 (42.8%) had severe disease activity. Twenty patients with mild
Clinical and therapeutic aspects of
disease activity had psycho-social disorders (71.1%), of the patients
PMS comorbid with depressive with severe activity, 28 had psycho-social disorders (84.5%). From
disorder 16 patients with low disease activity, only 6 (37.5%) had psycho-
R. Iakimova1* , M. Stoianova1 , M. Stoimenova-Popova2 , P. social issues.
Chumpalova2 , I. Veleva2 , L. Tumbev2 Conclusions.– From this study it was found that psycho-social
1 Medical University, Psychiatry and Medical Psychology, Sofia,
disorders are prevalent in patients with longstanding RA. These dis-
Bulgaria; 2 Medical University, Psychiatry and Medical Psychology, orders are associated with disease activity and female sex. Because
Pleven, Bulgaria of their prevalence and impact on patients’ lives, these disorders
require an appropriate approach.
Disclosure of interest.– The authors have not supplied a conflict of Medium age for beginning of use of alcohol was 25 years old and
interest statement. duration of use was 20 years. About 45% of patients have no psy-
chiatric disorder except for alcohol use disorder and 55% of them
have co-morbid psychiatric disorder.
E-PV0155 Conclusions.– The most common psychiatry disorder was BMD
A depressive disorder masking a (34.5%) after that Sever depression (22.5%) and Anxiety disorders
gender dysphoria: a case report with 12.4% and schizophrenia with 10.3% respectively. Due to high
W. Kabtni* , C. Bencheikh, O. Zeriaa, M. Hsayri, A. Baatout, I. prevalence of axis 1 psychiatric disorders in patients with alcohol
Bouzouita, M.W. Krir, H. El Kefi, A. Oumaya abuse concise interview and history and if required comprehensive
Military Hospital, Psychiatry Department, Tunis, Tunisia history is also suggested.
interest statement.
Background and aims.– Gender dysphoria is a new entity introduced
in the Diagnostic and Statistical Manual of Mental Disorder V that
often starts in the childhood. Despite the psychological distress and E-PV0157
the significant alteration of social and academic life that it causes, Effect of methadone, buprenorphine
it remains misdiagnosed. and opium tincture maintenance
This case report aims to describe a case of gender dysphoria masked
therapy on sexual function
by depressive disorder.
A. Kheradmand1* , A. fazeli2
Methods.– A patient case is presented with associated literature 1 Shahid Beheshti University of Medical Sciences, Taleghani Hospital
review.
Research Development Committee, Tehran, Iran; 2 Shahid Beheshti
Results.– Mr. NL, aged 17, an assigned male at birth, with no medical
University of Medical Sciences, Medical School, Tehran, Iran
history, is a student in the third year of secondary school. * Corresponding author.
The patient was referred by his parents initially for a decline in
school results with a tendency to isolation evolving since one year. Background and aims.– methadone or buprenorphinemaintenance
At the interview, the depressive symptomatology was in the first treatment is a common approach in opiate use disorders. In recent
place. The patient was put on antidepressant treatment combined years; there has been a growing interest in using opium tincture for
with supportive psychotherapy. detoxification and maintenance treatment of opiate dependence
Through the psychotherapy sessions, it was possible to emphasize in Iran. The aim of this study is to the comparison of sexual dys-
the presence of a strong desire to be a girl, he would prefer to dress function in patients with methadone maintenance therapy (MMT),
like a girl, playing often the stereotyped “girlish” games along with buprenorphine maintenance therapy (BMT) and Opium Tincture
girls’ group. In addition, he tells with great suffering and sadness maintenance therapy (OMT).
that he “is trapped in the wrong body” and he expresses an intense Methods.– This randomized, double-blind trial was conducted from
desire to acquire feminine physical forms. November 2017 to February 2018 in an addiction quitting clinic in
The diagnosis of gender dysphoria was retained. The patient is still Tehran, Iran. The study sample consisted of opium-addicted men
going through psychotherapy sessions to help him make the right who candidate for maintenance therapy. Participants (N = 84) were
decision. randomly assigned to three groups (of the equal number), receiv-
Conclusions.– An early positive and etiological diagnosis of gender ing either methadone (N = 28), buprenorphine (N = 28) and opium
dysphoria will prevent a psychiatric complication that may hinder tincture (N = 28), The mean score of sexual function was calculated
therapeutic management. by the Arizona Sexual Experiences Scale (ASEX) in first and after 3
Disclosure of interest.– The authors have not supplied a conflict of months after therapy.
interest statement. Results.– Although there was no significant different in ASEX
scores in beginning and in end of the study between three groups
(p > 0.05), but this difference was significant in each group in com-
E-PV0156 paring by themselves.
Of psychiatric disorders in alcohol Conclusions.– These results showed that sexual dysfunction of OMT-
users attendance to Tehran outpatient similar to MMT and BMT and should be evaluate by clinicians during
alcohol withdrawal clinics in 2018 these maintenance treatments.
A. Kheradmand1* , S.S. Sadr2 , A. Jahandideh3 Disclosure of interest.– The authors have not supplied a conflict of
1 Shahid Beheshti University of Medical Sciences, Taleghani Hospital interest statement.
Research Development Committee, Tehran, Iran; 2 Shahid Beheshti
University of Medical Sciences, Imam Hosein, Tehran, Iran; 3 Shahid
E-PV0158
Beheshti University of Medical Sciences, Medical School, Tehran, Iran
* Corresponding author. Psychosocial rehabilitation of
servicemen participants of military
Background and aims.– a
operations with traumatic injuries of
Methods.– This is a cross-sectional study on 105 alcohol users who
were referred to INCAS (Iranian National center for Addiction Stud- great vessels of extremities, which
ies). was complicated by disorders of
For all the participants alcohol use questionnaire and demographic adaptation
questionnaire were completed and prevalence of co-morbid psy- V. Koshchii1* , I. Strelnikova1 , Y. Koshchii2
chiatric disorders was surveyed using SCID-1. 1 Kharkiv National Medical University, Psychiatry- Narcology and
Results.– Most of participant were aged between 30 to 50 years old. Medical psychology, Kharkiv, Ukraine; 2 State Institution “Institute of
None of them were above 70 years old and only one of them was General and Emergency Surgerey named after V.T. Zaitsev NAMS of
below 19 years old. 23.8% of them had history of psychiatric visit Ukraine”, Emergency Surgerey, Kharkiv, Ukraine
and 16.2% had history of hospitalization in psychiatry ward. 91.4% * Corresponding author.
(n = 96) of participants were male and 8.6% (n = 9) were female.

Use of substances other than alcohol was also studied in partici- Background and aims.– During military operations, mental disor-
pants which most used were opium (26.7%) and cannabis (16.2%). ders are common forms of pathological states that arise both in
military servicemen of the Armed Forces of Ukraine, prisoners, their we need to enhance the knowledge of such comorbidities to a better
relatives and refugees. quality of medical care.
Adaptation disorders often take a protracted course, greatly reduce Disclosure of interest.– The authors have not supplied a conflict of
the quality of life of a sick serviceman, impair the ability to work, interest statement.
violate social adaptation, and deepen the devastating effects of the
disease itsel.
Psychosocial rehabilitation of servicemen with traumatic injuries E-PV0160
of great vessels of extremities, which was complicated by disorders Experience in the use of autologous
of adaptation using psychoeducation. bone marrow mesenchymal stem cells
Methods.– A comprehensive clinical and psychopathological
(ABMMSC) in treatment of personality
examination of 153 military servicemen – military operations par-
ticipants, with traumatic injuries of the great vessels of extremities, and behavioral mental disorders and
which was complicated by disorders of adaptation, psychoeduca- drug-resistant epilepsy
tion. A. Martynenka* , F. Khlebokazov, N. Misuik, T. Dakukina, V.
Results.– All patients received psychopharmacotherapy. Main Zakharevich, A. Dudarchik
group: 97 patients, participated in psychoeducational program, Republican Scientific-Practical Center of Mental Health, Department
received psychopharmacotherapy. Control group: 56 patients, of Mental and Behavioral Disorders- Section Science, Minsk, Belarus
received regulated therapy. It was established the significant pos-
itive dynamics of the level of social functioning in patients of the
Background and aims.– Clinical effects of transplantation ABMMSC,
main group, (p < 0.05) exceeds the corresponding changes in the
allow to consider method as a new, promising direction in the
control group; the transformation of coping strategies, the tran-
treatment of personality and behavioral mental disorders and drug-
sition of the maladaptive types of an attitude towards the disease
resistant epilepsy.
into adaptive ones, the development of a personal resource through
Development of a new method of treatment of personality and
personal realization, improvement of interpersonal relations and a
behavioral mental disorders and drug-resistant epilepsy using
sense of support of loved ones, which determines a high level of
ABMMSC, which will enhance cognitive skills, reduce frequency of
quality of life renewal.
seizures, increase period of remission.
Conclusions.– The obtained results allowed to substantiate expe-
Methods.– Cultural, morphological, molecular-genetic, clinic-
diency of use of psychoeducation in the system of psychosocial
functional, pathopsychological.
rehabilitation of sick servicemen with traumatic injuries of great
Results.– Transplantation of ABMMSC was performed in 20 patients
vessels of extremities, which was complicated by disorders of adap-
with drug-resistant epilepsy. 2 courses of transplantation were
tation.
done; 1 course is single transplantation of ABMMSC intravenously,
one week after - endolumbic. Cellularity for intravenous transplan-
interest statement.
tation – 62,75*106, endolumbial – 8,75*106, viability - not less than
95%. Expression of surface markers meets the criteria of the IACT.
E-PV0159 After 12 months, clinical remission had 3 patients, decrease seizure
by more than 50% - 15, no effect - 2, no deterioration after transplan-
Psoriasis exacerbation in bipolar
tation; all patients enhanced cognitive skills. Comparison group -
disorder relapse: a case report clinical effect - remission and a decreasing frequency of seizures
R. Maamouri1* , N. Bram2 , C. Ben Said1 , I. Ben Romdhane2 , W. more than 75% wasn’t noted, 10–75% decrease - 11 patients, with-
Homri2 , R. Labbane2 out effect – 7; only 8 patients enhanced their cognitive skills.
1 Medical School of Tunis, Psychiatry, Tunis, Tunisia; 2 Hospital Razi,
Conclusions.– The study clearly shows that the course transplanta-
Psychiatry ‘C’ department, Mannouba, Tunisia tion of ABMMSC is a modern and promising method of treatment
of personality and behavioral mental disorders and drug-resistant
epilepsy. The results demonstrated in the study group are supe-
Background and aims.– Psoriasis is a chronic and systematic disease
rior to those in the comparison group. Also, method is safe-in the
that equally affect men and women in 1.5% to 2% of the population,
main group, no patient had significant adverse or deterioration. The
it’s a frequent skin disorder that needs a long-term pharmacological
study should be continued to get detailed results.
treatment and may have a profound impact on the quality of life.
Otherwise, psychiatric disorders and especially bipolar disorder are
interest statement.
some of the associated problems that can be observed in patients
with psoriasis.
Methods.– We will discuss a clinical case and will eventually pro-
E-PV0161
ceed to a literature review about this subject.
Results.– A 60 years old man suffering since four years from psoriasis The relationship between impulsivity
and stabilized under a local medical treatment, was hospitalized for and alexithymia in a sample of strong
psycho-motor instability and logorrhea. The diagnosis of a maniac nicotine addicted. a preliminary study
episode was assessed by the fifth edition of the diagnostic and D. Montanaro1* , C. Medici2
statistical manual of mental disorders (DSM -5). The patient has 1 Freelance, Freelance, Rome, Italy; 2 Specializing in Psychiatry,
many stress factors: he was about to retire, he got removed from University of Rome La Sapienza, Rome, Italy
his usual work spot and he has a conflict with his brother. Two * Corresponding author.
months before the maniac episode, the patient had an itching thick
red scaly patch of skin. During his hospitalization, he got risperi- Background and aims.– Given the correlation between tobacco
done and chlorpromazine and was examined by a dermatologist addiction and impulsivity, this study means to evaluate the role of
who assessed an exacerbation of psoriasis and prescribed adequate alexithymia in the relationship between impulsivity and tobacco
local treatment. The evolution was favorable, both disorders was addiction. Alexithymia is defined as a difficulty in the mental
managed. representation of emotions due to a loss of integration between
Conclusions.– The association between psychiatric disorders and physiological and cognitive component of emotions. Alexithymia
dermatological conditions is well known, but the dermatologist has can be characterized by an operative kind of thought, lacking
often a difficulty to identify the psychological distress that’s why in imagination, fantasy or oneiric activity that, according to the
“Human Birth Theory” by Massimo Fagioli, are fundamental to E-PV0163

ensure the possibility to mentally elaborate psychic and physical Psychiatric disorders in cancer
sensation. Consequently, a lack of psychophysical sensibility could
patients
prejudice the imaginative thinking process, mystifying our experi-
S. Omri* , M. Daoud, W. Bouattour, M. Maalej, R. Feki, L. Zouari, N.
ence awearness (Atzori, 2017), and making emotional experience
Charfi, J. Ben Thabet, M. Maalej
less comprehensible and intense.
Psychiatry “C” Department at Hedi Chaker University Hospital- in
Methods.– This preliminary study examines the correlation
Sfax -Tunisia, Psychiatry “C” Department at Hedi Chaker University
between the dimensions of impulsivity and alexithymia in a sam-
Hospital- in Sfax -Tunisia, Sfax, Tunisia
ple of 30 help-seekers related to a Service for Addictions, diagnosed * Corresponding author.
with Tobacco Addiction, through the analysis of the results of a test
battery distributed at the admission. Background and aims.– Although a diagnosis of cancer today may
Results.– Test results suggest that alexithymia has a role in leading no longer be considered to be the equivalent of a death sentence,
to impulsive action. The greatest correlation was found between many previous studies have revealed that such a diagnosis places
alexithymia and the impulsivity sub-factor called “lack of reflection many kinds of emotional burden on a patient. The study aims to
and behavioral planning”. investigate the characteristics, reason for psychiatric consultation
Conclusions.– The difficulties in mentalization, due to the lack and psychiatric diagnosis of patients with cancer.
of psychophysical sensitivity, would expose to the possibility of Methods.– A retrospective study, involving 50 outpatients diag-
acting-out and the search for sensory stimulation, aimed at over- nosed with cancer and followed in the psychiatry “C” department at
coming these deficiencies and maintaining the integrity of the self Hedi Chaker university Hospital, in Sfax -Tunisia, between January
(Atzori 2017, 2018). The tendency to impulsive action could, there- 2016 and September 2018. Sociodemographic, clinical and thera-
fore, be sustained by a lack of psychophysical sensitivity that alters peutic data was collected from their medical records. The statistical
the process of mentalization. study was carried out using the SPSS software (18.0).
Disclosure of interest.– The authors have not supplied a conflict of Results.– The obtained results showed that 1.75% (50/2851) of
interest statement. outpatients had a cancer (average age = 32 years; sex-ratio = 1.8).
The most common types of cancer were especially colon cancer
(30%) and breast cancer (28%). Thirty-five percent of patients had
E-PV0162 metastatic cancer. The major grounds for consultation were depres-
Why and how to create “identified sive and anxious symptoms (53%) and sleep disturbance (28,2%).
beds” in palliative care for psychiatric The time elapsing between cancer diagnosis and the psychiatric
patients in long term unit? consultation was five months. The most frequent psychiatric diag-
A. Nasfi noses were depression (33%) and anxiety disorders (31%). Poor
Usld la Roseraie EPS Maison Blanche, Seine Saint Denis, Neuilly Sur adherence and irregular follow-up were noted in 82% of patients.
Marne, France Conclusions.– Psychiatric disorders represent a significant comor-
* Corresponding author. bidity in oncology and their neglect may have significant negative
consequences on the quality of life of patients. Consideration
Background and aims.– Our Long stay Unit take in charge psychiatric should be given to include a psychologist in the multidisciplinary
patients. Most of them harbore many co-morbidities and die in the evaluation of the cancer patient.
structure. Because of their psychotic disorders, the approach of pain Disclosure of interest.– The authors have not supplied a conflict of
and end of life is complex and requires a specific approach. interest statement.
Methods.– Progressive implementation of a palliative approach to
accompany the end of life.
Results.– E-PV0164
1) Creation of an evaluation of professional practice, working group Refraktarity in a clinical case with
on end of life. BPD and OCD co-morbidity
2) Conducting an audit on end-of-life support practices. This audit T. Pengili1* , I. Prifti2 , M. Lici3 , E. Murati3 , A. Hashorva3
highlighted the previous experience of the caregivers in this field 1 University Medical Center “Mother Teresa”, Psychiatry, Tirana,
but also the need for a better support of the professionals, a Albania; 2 University Medical Center of “Mother Theresa”, Psychiatry,
mobile team of palliative care, and training. Tirana, Albania; 3 University Medical Center “Mother Theresa”,
3) A study carried out on the psychiatric patients who died in the Psychiatry, Tirana, Albania
structure for 10 years showed that despite a lower age than the * Corresponding author.
geriatric population, 26% died during this period mainly due to
tumors. The accompaniment was carried out for 90% of people Background and aims.– Studies show that these disorders coexist in
in our unit. 18–25% of cases where 50–60% of them are treated efficiently. We
4) Establishment of a medical and paramedical training plan, are going to discuss from our clinical experience a difficult case of
including a university diploma of palliative care program. a 23-year-old patient with a three-year history of the disease.
5) Establishment of specific support for caregivers by a psycholo- Methods.– The initial symptoms were disorientation and amnesia
gist. and as a result we suspected for an organic condition. The patient
6) Creation of specific care protocols took a brain MRI, which resulted with asequential lacunar hyper-
7) Information for patients and their family signal in flair positioned on the 4th ventricle, but according to the
8) Convention with a mobile team of palliative care neurologist this did not affect the condition of the patient. He was
Conclusions.– This innovative project to create” Identified Beds “Pal- treated for over 2 years with various treatment schemes. During
liative Care, currently submitted to the Health Agency, will allow an this time he displayed therapeutic resistance and he did notremis-
effective recognition of the work done by caregivers and the means sion. The first hospitalization was back in 2015 and at the time he
necessary for its operation. It will allow to offer psychiatric patients came as a suicidal attempt and was diagnosed with OCD. Accord-
better end-of-life care without breaking the psychiatric care in their ing to his family, the suicidal attempt was a kind of a demonstrative
unit. action.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The psychosis was dominated within a few days in the
interest statement. clinic but we had remaining symptoms such as: obsessive thinking,
compulsive behavior, depersonalization, derealysis, tenseness of
confidentiality with other medical staff, ecopraxis, strongly deny- * Corresponding author.
ing the hallucinations and delusions, which excluded a diagnose of
schizophrenia and reinforced the theory of a BPD diagnose. Background and aims.– A study in progress assessing eating dis-
Conclusions.– He is now being treated with Olanzapine 20 mg, Ven- order risk (EDR) among overweight and obese PCOS patients of
lafaxine 75 mg, Lorazepam 5 mg, CarbonatLithiumi500 mg but his reproductive age and a matched control group. The assessment and
condition continues to be not good. comparison of EDR among the PCOS and control group as well as
Disclosure of interest.– The authors have not supplied a conflict of potentially finding a correlation between specific biochemical and
interest statement. hormonal levels and the risk of eating disorder development.
Methods.– The study is expected to involve 200 women of reproduc-
tive age with a body mass index ≥ 25. They are qualified as PCOS or
E-PV0165 control utilizing the Rotterdam criteria. They subsequently undergo
Moving towards personalized a series of biochemical and hormonal tests as well as a psychiatric
assessment utilizing a structured interview and a series of ques-
medicine in psychiatry: a value of
tionnaires. Some of the diagnostic tools include: Mini-International
genotyping in assessing of risks and Neuropsychiatric Interview, Bulimic Investigatory Test Edinburgh
benefits in patients receiving SSRI’S (BITE), Binge Eating Scale (BES) and the Eating Disorder Examina-
and cardiovascular medication tion Questionnaire 6.0 (EDE-Q).
S. Petrykiv1* , M. Arts2 , L. de Jonge3 Results.– The study currently includes 51 patients (31 PCOS, 20 con-
1 Maastricht University Medical Center, Department of Clinical trol). In x (%) PCOS vs. x (%) controls increased EDR was noted.
Pharmacy and Pharmacology, Maastricht, The Netherlands; 2 Mental Utilizing BITE 45.2% vs. 40%. Utilizing BES 32.3% vs. 25%. The sub-
Health Care –Western North Brabant GGZ-WNB, Department of Old ject groups are as of yet too small to draw statistically relevant
Age Psychiatry and Neuropsychiatry, Halsteren, The Netherlands; 3 conclusions or attempt to correlate eating disorder risk to specific
Leonardo Scientific Research Institute, Department of hormonal and biochemical imbalances.
Neuropsychiatry, Groningen, The Netherlands Conclusions.– Both patient groups demonstrate increased overall
* Corresponding author. risk for developing eating disorders as compared to the general
population. The PCOS group appears to display a higher percent-
Background and aims.– A high prevalence of poor metabolizers age of subjects at significant risk of having or developing an eating
(6-10%) in western population is a potential source of drug-drug disorder. No statistically significant correlation has yet been found
interactions. To date, the human pharmacokinetic data on SSRi’s between hormonal and biochemical levels and eating disorder risk.
and cardioprotective drugs are inconclusive because of the wide Disclosure of interest.– The authors have not supplied a conflict of
interpersonal variation in outcomes, a limitation which can be elim- interest statement.
inated by a personalized approach through genotyping to identify
patients at risk (slow metabolizers).
Methods.– First, we performed a meta-analysis to assess the effect E-PV0167
of SSRI’s on percentage change in AUC of statins in general pop- HCV+ among drug-dependent patients
ulation. Secondly, we reviewed the neuropsychiatric effects of
admitted to the detoxification/dual
antihypertensive drugs when co-administrated with SSRI’s. Finally,
we speculated on the value of genotyping as a potential tool to disorder unit of salamanca in the
identify patients at risk. period 2014 to 2017
Results.– Fluvoxamine increased the mean substrate AUC 0- C. Roncero1,2,3* , C. Llanes4 , N. Casado1 , J. de la Iglesia1 , M.T.
[infinity] by 112.47% (CI: 21.08; 203.86). The AUC 0-[infinity] levels Lozano1 , M.Á. Garzón5 , M.P. Ándres1 , E. Alvarez-Lamas5 , A.
of CYP3A4 substrates were marginally increased by 11.1% in citalo- Pérez-Madruga1 , M. Rodriguez5 , E. Dominguez5 , C.
pram treated subjects (CI: −20.63; 42.86), by 10.8% in fluoxetine Gamonal-Limcaoco1 , M.V. Martín5 , E. Valades5 , A. Álvarez5
1 University of Salamanca Health Care Complex, Psychiatry,
treated group (CI: −25.53; 47.16), by 8.18% in those who received
paroxetine (CI: −3.49; 19.86) and by −3.3% in venlafaxine treated Salamanca, Spain; 2 University of Salamanca, Psychiatry, Salamanca,
group (CI: −5.85; −0.75). Based on literature search, clinically Spain; 3 University of Salamanca, Institute of Biomedicine of
important links may exist between SSRI’s with propranolol, meto- Salamanca, Salamanca, Spain; 4 Zamora Health Care Complex,
prolol and amlodipine. Psychiatry, Zamora, Spain; 5 University of Salamanca Health Care
Conclusions.– Citalopram, fluoxetine, paroxetine and venlafaxine Complex, Dual Diagnosis Unit. Psychiatry, Salamanca, Spain
are almost certain to be safe with all statins. Fluvoxamine inhibits
CYP3A4 metabolic pathway and is potentially unsafe in cotherapy
with atorvastatin, simvastatin and lovastatin. Co-administration Background and aims.– Hepatitis C is a disease which can be trans-
of lipophilic ␤-blokkers are thought to be associated with higher mitted through blood or sexual intercourse. It is very common in
rates of neuropsychiatric consequences. We advocate for genotyp- addicted and Dual Disorder (DD) patients (those who present an
ing in patients experiencing adverse events and in those receiving addiction and another mental disorder).
polypharmacy. Objective.– To analyze the characteristics of patients with HCV
Disclosure of interest.– The authors have not supplied a conflict of infection admitted during 2014–2017 to the Detoxification/Dual
interest statement. disorder Unit of the Psychiatric Service.
Methods.– Descriptive, observational, retrospective study of 830
inpatients, among which 34% (279) were infected by HCV.
E-PV0166 Results.– Of the patients HCV+:80% were male, 46 years old on aver-
age. 30% were as well infected with HIV. 69% of them had DD, with
Eating disorder risk in overweight and
the following concurrent diagnoses: personality disorders (45%),
obese polycystic ovary syndrome affective disorders (35%), anxiety disorders (13%) and psychotic
patients disorders (10%). Additionally, 70% of the patients presented opiate
D. Rodriguez-Paris1* , B. Banaszewska2 , A. Remlinger-Molenda3 dependence, 35% cocaine dependence and 16% alcohol dependence.
1 Provincial Neuropsychiatric Hospital in Kościan, Psychiatry, The main route of consumption before the hospitalization was oral
Kościan, Poland; 2 Poznań University of Medical Sciences, Department in 64%, pulmonary in 30%, injected in 4% and snorted in 2%. In
of Reproductive Endocrinology, Poznań, Poland; 3 Poznań University many cases they had used the intravenous route in the past. In all
of Medical Sciences, Department of Adult Psychiatry, Poznań, Poland the 279 cases the detection of anti-HCV antibodies was confirmed.
Only 13% had recived treatment, 23 patients had completed treat- Methods.– 120 male patients were examined, mean age 30.3 ± 0.63.
ment with Interferon and 14 had been treated with direct-acting The data of an anamnesis, clinical and psychological examination
antivirals (DAAs). Patients with positive anti-HCV antibodies who (Life Style Index, “Method for diagnosing susceptibility to deviant
had not received treatment were referred to specialized services to behavior” (SDB), Orel A.) were performed. Data was processed using
complete the study and assess the need for treatment. R software. P-value <0.05 was considered statistically significant.
Conclusions.– Patients with SUD and DD are more at risk of get- Results.– Respondents were in conditions excluding drug use,
ting HCV infection. Access to HCV treatment is improving, but until in remission of PS. The intenseness of the PD was observed
recently the need to adequately inform treatment options for this (75.23% ± 0.23). The PD system is ranked from the most
group has been neglected. intense: intellectualization (88.40 ± 1.64), rejection (82.96 ± 1.90),
Disclosure of interest.– The authors have not supplied a conflict of displacement (81.03 ± 2.01), rationalization (79.57 ± 1.59), sub-
interest statement. stitution (72.19 ± 2.42), regression (62.87 ± 2.85), compensation
(61.65 ± 2.37), and projection (58.50 ± 2.90). The indicators are
higher than the norm: setting for socially desirable answers
E-PV0168 (60.28 ± 0.99); propensity to addiction (54.15 ± 0.64), to abnormal
Alcohol and drug abuse in psychiatric behavior (53.3 ± 0.84); to delict (52.88 ± 0.70). A correlation was
patients and healthy controls found between all SDBs (r = 0.52 ± 0.52 p < 0.050).
M. Pacetti1 , F. Ambrosini2 , M. Sanza3 , R.P. Sant’angelo4* Conclusions.– Stress in a homogeneous environment caused an
1 Ausl Romagna, Mental Health- CSM, Forli, Italy; 2 University of intensification of destructive PD, which provoked addictive, abnor-
Bologna, Faculty of Psychology, Cesena, Italy; 3 Ausl Romagna, Italy; 4 mal, delinquent, incommunicative behavior; the separation regime
Ausl Romagna, Mental Health, Cesena, Italy stimulated the control of addictions.
interest statement.
Background and aims.– Alcohol and drug addictions have a high
incidence in Borderline Personality Disorder (BPD). However, the
presence of addiction is rarely examined comparing an heteroge- E-PV0170
neous sample of psychiatric disorders and controls (HC). Impact of vitiligo on life quality
Our aim is to compare the incidence of alcohol and drug abuse in I. Sellami1* , W. Smaoui2 , N. Kotti1 , A. Feki3 , A. Masmoudi4 , K. Jmal
patients with BPD, Affective disorders (AD), Psychosis (P) and HC. Hammami1 , H. Turki4 , M.L. Masmoudi1 , M. Hajjaji1
Methods.– 112 individuals were assessed using SCID I and II. The 1 CHU Hedi Chaker, Occupational Medecine, Sfax, Tunisia; 2 CHU
final sample was divided in BPD (24,1%), P (24.1%), AD (22.3%) and Habib Bourguiba, Urology, Sfax, Tunisia; 3 CHU Hedi Chaker,
HC (29.5%). A self-report questionnaire was used to collect data Rhumatology, Sfax, Tunisia; 4 CHU Hedi Chaker, Dermatology, Sfax,
on demographics, lifetime drug abuse and injection drug use. As Tunisia
screening the TWEAK test was administered, considering a score * Corresponding author.
higher than 3 as indicative of alcohol abuse or addiction. The four

groups were compared using chi-squared test. Background and aims.– Vitiligo is an autoimmune illness which
Results.– BPD has higher score at TWEAK than P and HC, exhibiting affects the skin. This affection may have an important impact on
a score similar to that of AD. Drug abuse in BPD is more frequent self-esteem and psychological stability.
than in HC, P and AD. However, the lifetime injection drug use is The aim of this study is to assess the impact of vitiligo on the quality
similar in the three patient groups. of life.
Conclusions.– BPD seems to behave similarly to AD for alcohol Methods.– We conducted a cross-sectional study. Fifty patients with
abuse. However, the incidence of druga ddiction is higher in BPD vitiligo answered a questionnaire on quality of life. The quality of
than in the other groups, confirming the literature. life was assessed using the Dermatology Life Quality Index (DLQI)
Disclosure of interest.– The authors have not supplied a conflict of in its Arabic version.
interest statement. Results.– The sex-ratio Male/Female was 1. The mean age was
46.1 ± 12.3 years. Sixty-five percent had generalized vitiligo. The
mean DLQI score was 6.34 ± 6.44. The quality of life was signifi-
E-PV0169 cantly impaired in 30% of the patients. The impact on quality was
The influence of psychological greater in older patients and women. Vitiligo affecting face was
associated with a greater impact on the quality of life.
defenses on the behavior of patients
Conclusions.– Vitiligo deteriorates the quality of life. Its psychiatric
with a paranoid form of effect must be well-estimated in order to preserve patients quality
schizophrenia addicted on synthetic of life.
cannabinoids (SPICES) Disclosure of interest.– The authors have not supplied a conflict of
G. Selivanov1* , N. Bokhan Aleksandrovich2 interest statement.
1 Siberian Federal Scientific Clinical Center of Federal
Medico-Biological Agency- Seversk Clinical Hospital, General
Psychiatric Department- Medico-Rehabilitative Department- E-PV0171
Psychoneurological Clinic, Seversk, Russia; 2 Mental Health Research A case of Niemman-Pick’s disease in
Institute- Tomsk National Research Medical Center- Russian psychiatry
Academy of Sciences, Addictive States, Tomsk, Russia M. Stoimenova-Popova* , E. Dimitrova, A. Todorov, G. Georgiev, P.
Chumpalova
Medical University, Psychiatry and Medical Psychology, Pleven,
Background and aims.– Stresses activate psychological defenses
Bulgaria
(PD), form abnormal behavior in patients with paranoid * Corresponding author.
schizophrenia (PS), addiction on synthetic cannabinoids (SC).
To rehabilitate patients with PS dependent on SC, it is necessary to Background and aims.– The patient with Niemann-Pick disease
analyze the effect of PD on their behavior. type B usually presents with hepatosplenomegaly, pathologic alter-
The objective was to study the influence of PD on the behavior of ations on lungs, pancytopenia, caused by splenomegaly, sometimes
patients with PS addicted on SC. there are eye abnormalities (cherry-red spot), neurological symp-
toms, most often mental retardation, peripheral neuropathy and E-PV0173

seizures, bones also may be affected. Comorbidities in patients diagnosed
Methods.– A 35-year-old woman is hospitalized in a psychiatric
with major depressive disorder
clinic. About a month before hospitalization, she became tense,
B.D. Suciu1* , R. Păunescu2 , I.V. Miclut, ia2
psychomotor agitated, with lively speech, mentally torn, unable to 1 Children’s Emergency Hospital, Psychiatry Clinic I, Cluj Napoca,
cope with her daily activities. She has psychotic symptoms since
Romania; 2 Iuliu Hat, ieganu University of Medicine and Pharmacy,
the age of 17. Till now she was treated in different psychiatric
Neurosciences Department, Cluj Napoca, Romania
departments for affective and psychotic symptoms. In 2015 she was * Corresponding author.
diagnosed with Niemann-Pick Type B disease – an intermediate
form, because of neurological symptoms that she has. Background and aims.– Studies reveal the presence of many psychi-
Results.– After reviewing the medical history our team decided to atric and somatic comorbidities in depressed patients. It is known
start treating the patient with Ziprasidone 40 mg/daily, Quetiap- that major depressive disorder has a high prevalence, a chronic
ine 100 mg/daily and Valproic acid 1000 mg/daily. Diagnosis was course and it is often associated with numerous comorbidities
defined as Organic Mood Disorder. At the first week of the treat- which have a considerable impact on the patient’s quality of life.
ment we observed improvement in psychotic symptoms. Gradually Our aim was to evaluate the comorbid conditions of patients diag-
there was a reduction in the psychomotor agitation, she aligned nosed with major depressive disorder that were admitted to the
mentally, despite of discrete flight of ideas, perceptual disturbances Psychiatry Clinic in Cluj Napoca.
were decasualized. The patient became notably autonomous to Methods.– The study included 40 patients (aged between 23 and
self-care and move independently. 65) diagnosed with recurrent major depressive disorder (according
Conclusions.– Although the psychotic symptoms of Niemann-Pick to ICD-10 and DSM-V), that were evaluated during their hospi-
type B disease - intermediate form are uncommon, in the case pre- tal admission. The severity of depression was quantified clinically
sented, they determine the poor quality of life and lead to a more with the help of the Hamilton Depression Rating Scale -17 items,
severe course of the disease. while the comorbid conditions were identified using the Mini Inter-
Disclosure of interest.– The authors have not supplied a conflict of national Neuropsychiatric Interview and also by consulting the
interest statement. patients’ charts.
Results.– The group had similar gender distribution, different lev-
els of education and married patients were predominant. 77% of
E-PV0172 patients had a medical comorbidity, represented by: cardiovascular
A case of ekbom syndrome recurrent disorders, diabetes, chronic obstructive pulmonary disease, hep-
in patient with dual diagnosis and atitis and anaemia. In the same time, 63% of patients had another
chronic insomnia psychiatric condition, represented mostly by anxiety disorders or
E. Suarez alcohol problems.
Hospital Infanta Sofía, CSM de Alcobendas, Psychiatry, SAN Sebastian Conclusions.– These results are in accordance with the majority of
de los Reyes, Spain studies and due to the fact that these disorders coexist with major
* Corresponding author. depressive disorder, they could be considered an important source
of mortality.
Background and aims.– Since the middle of the 19th century reports Disclosure of interest.– The authors have not supplied a conflict of
have appeared in the scientific literature of patients who claimed interest statement.
to be infested with parasites without medical evidence to prove
it. It was first described by Thibierge in 1894, calling it “Acaro-
phobia”, and then by Ekbom in 1938, in his work Der praesenile E-PV0174
dermatozoenwhan. Ekbom syndrome is a mental disorder in which Usher syndrome and psychiatric
the patient has the monothematic delusion of being infected by par- symptoms: a case report
asites. It is an uncommon condition that was initially studied by A. Taamallah1* , M. Daoud2 , S. Taleb3 , H. Ben Ammar4 , Z. El
dermatologists. The exactly etiology is unknown to date, though Hechmi5
several causes have been proposed, including metabolic dis- 1 Resident, Psychiatric Department “F” /Razi Hospital, Manouba,
eases (among other physical causes), psychiatric disorders, drugs, Tunisia; 2 Resident, Psychiatric Department/Razi Hospital, Manouba,
etc. Tunisia; 3 Resident, Psychiatric Department/ Razi Hospital, Manouba,
Methods.– Case report To analyse the behavioral changes in a 48 Tunisia; 4 Doctor, Psychiatric Department “F”/ Razi Hospital,
year-old patient, with the diagnosis of dual disorder (affective dis- Manouba, Tunisia; 5 Professor, Psychiatric Department “F”/ Razi
eases + drug dependence) who had a delusion of infestation and Hospital, Manouba, Tunisia
insomnia. The patient was treated with antipsycotic depot drugs. * Corresponding author.
He responds effectively but insomnia remains. After 1 year, the
patient decided to refused the antipsycotic treatment. 8 months Background and aims.– Usher syndrome is an autosomal reces-
later he relapse. I begun with the antipsycotic depot treatment sive genetic disorder manifested by hearing impairment, retinitis
and he responds effectively less the insomnia I treated with some pigmentosa and variable vestibular deficit. Few studies suggest
combination of drugs without results. The combination of the possible mechanisms of association between mental disorders and
Perampanel with other hipnotic drugs inprove the quality of de Usher syndrom. The most common manifestations are psychotic
sleep. symptoms. Mood and behavioral disorders are rarely described.
Results.– The Ekbom syndrome is a rare subtype of delusional dis- The aim of our work is to discuss the link between Usher syn-
order that usually responds to antipsychotic drugs effectively. drom and psychiatric manifestations, with a review of the current
Conclusions.– The síndrom can be recurrent specialy if the period literature.
of treatment is short. The syndrom are often associate with chronic Methods.– A case report discussed with a literature review, based
insomnia. Perampanel inprove the quality of de sleep. in Pubmed, using “Usher syndrom”, “psychiatric symptoms” as key
Disclosure of interest.– The authors have not supplied a conflict of words.
interest statement. Results.– IM, a 40 years old female, was born full term with congen-
ital hypoacusis. His language were delayed. She had sub-average
intellectual and social functioning since childhood. She developed
decreased vision at night. She is able to perform simple household
tasks and self-care activities. His older brother and her father also E-PV0176
have congenital deaf-blindness and mental retardation. There was Paliperidone palmitate for a dual
a known history family of bipolar disorder. She was hospitalized
diagnosis forensic psychiatric patient
for change in mood, psychomotor agitation, decreased sleep and
G. Tzeferakos1* , A. Apostolopoulos1 , O. Vamvakouri2 , A. Douzenis1
strangulation suicide attempt. 1 University of Athens - Medical School, 2nd Department of
She was sad and anxious. She had anhedonia, suicidal ideation,
Psychiatry, Athens, Greece; 2 Hellenic Agency Against Drugs, OST Unit
low self-esteem and delusional ideas, treated with olanzapine
- Atticon Hospital, Athens, Greece
20 mg/day, fluoxetine 20 mg/day and anxiolytics. The symptoms * Corresponding author.
partly remitted. Ophthalmological examination showed pigmen-
tary changes in both retinas and high myopia. Audiometric Background and aims.– Almost 50% of patients with schizophrenia
evaluation were indicated. have a life time history of substance use disorder. These patients are
Laboratory investigations, brain scan and electroencephalogram characterized by: poor adherence to medication, multiple relapses
were normal. and hospitalizations (involuntary and voluntary), increased vic-
Conclusions.– Access to mental health services is particularly timization, violence, suicidality, and risk of HIV, HCV and HBV
difficult for deaf and deaf-blind people. The difficulties in com- infections. Quite often they are involvemed with the Criminal Jus-
munication are a challenge for patients and doctors to understand tice System.
symptoms. Further studies are needed to understand the link Methods.– We present a case of a young female dual diagnosis
between mental disorders and Usher syndrome. patient (schizophrenia and polytoxicomania), enrolled in an OST
Disclosure of interest.– The authors have not supplied a conflict of program with methadone, with a long history of multiple hos-
interest statement. pitalizations (mainly involuntary) and violent outbursts/arrests,
extremely poor adherence to medication, continuous abuse of
several psychoactive substances (BZD, MDMA, Heroin) and active
E-PV0175 psychotic symptomatology.
Treatment challenges in nonepileptic Results.– Upon her admission to our OST unit, the patient suffered
psychogenic seizures an acute psychotic exacerbation, after inhalation of metham-
J. Milczarek, A. Skiba, M. Łukasik, A. Orzechowska, M. Kowalczyk, phetamine, which led to her involuntary admission. During her
M. Talarowska* hospitalization, the patient was initiated PP 1 M 75 mg, which was
Medical University of Lodz, Department of Adult Psychiatry, Łódź, gradually titrated to 150 mg/monthly.
Poland We present her clinical course, as depicted by different scales
* Corresponding author. (PANSS, PSP, CGI-C and CGI-C, every 3 months) (table 1).
Background and aims.– Table 1 Clinical course depicted by different scales

Introduction.– Psychogenic non-epileptic seizures (PNES) are time- Scale Admission 3rd month 6th month
limited, paroxysmal disturbances movement, sensation, behavior
and consciousness that may resemble epileptic seizures. However PANSS 121 92 60
they are not the result of epileptic discharges in the central nervous CGI-S 7 6 4
system. Differentiating epileptic seizures (ES) from psychogenic CGI-C N/A 2 2
nonepileptic seizures (PNES) represents a challenging differential PSP 25 40 50
diagnosis. An accurate recognition is important in order to receive
the appropriate treatment but it is only the beginning of a difficult Conclusions.– PP 1 M seems to have helped stabilize the patient.
road. Psychological intervention are favorable treatment offered to Disclosure of interest.– The authors have not supplied a conflict of
people with PNES. interest statement.
Objectives.– The aim of the study was to present a case report of
patient diagnosed for organic mood disorder (F06.3) suffering from E-PV0177
nonelpileptic psychogenic seizures.
Addiction & ASD
Methods.– Case report.
P.J.M. Van Wijngaarden-Cremer
Results.– Patient aged 55. Hospitalized for the first time in 2017,
Dimence, Centre for Developmental Disorders, Zwolle, The
in ambulatory care since 2003, firstly diagnosed with recurrent
Netherlands
depressive disorders (F33) and mistakenly treated for epileptic * Corresponding author.
seizures. During second hospitality patient experience a high level
of anxiety, cannot cope with stressful situations. The behavior is Background and aims.– Dopamine plays a key role in a series of
described as neurotic, disinhibited, emotionally labile and uncon- seemly-unrelated conditions such as Parkinson’s disease, ADHD
ventional. Psychological tests indicate cognitive deficits - CNS and addiction. Autism spectrum disorders (ASD) are so to say at
damage characteristic for changes in the frontal and cortical struc- the intersection of these developmental disorders in the sense that
ture. individuals with ASD present with cognitive problems especially
Conclusions.– PNES is one of the most common medically unex- in the area of executive functions, motor oddities and preoccupa-
plained neurological symptoms. Patient diagnose for organic mood tions and stereotypies. The obsessive-compulsive preoccupations,
disorder with accompanying PNES seems to be a group of very lim- the motor stereotypies are functional in young children as they help
ited treatment option. Strong mechanism of repression, low level them cope with the stimuli overload that they experience. As devel-
of motivation, lack of insight and co-occurring cognitive deficits are opment progresses these behaviours can evolve into addictive like
insufficient psychological resources for effective therapeutic effect behaviours and substance abuse.
in the treatment of PNES in this case. Aim.– Can this be confirmed in a clinical population?
Disclosure of interest.– The authors have not supplied a conflict of Methods.– A two year cohort of patients admitted both to the out-
interest statement. patient and inpatient services of our department for developmental
disorders was thoroughly assessed. Data from development,
somatic and psychiatric appraisal, substance and behavioural
addictions were gathered.
Results.– It appeared that in 80% of the cases in this adult ASS sample
some behavioural and/or substance related addiction was found.
There were now significant differences with regard to gender in Background and aims.– Drug induced parkinsonism is a well-known
terms of prevalence but clearly in the type of addiction. In this pre- complication of several different drugs, mainly the neuroleptic. The
sentation the detailed outcomes will be presented and discussed. literature presents drug-induced parkinsonism as the second most
Conclusions.– It is clear that in adults with ASD addiction is an common cause of parkinsonism. The incidence of such cases may
important issue to take into consideration. But instead of aim- have declined with the use of atypical antipsychotics. In most case,
ing straight away at detoxification and behaviour modification, it the symptoms disappear with cessation of the drug, but in some
appears to be crucial to make a functional analysis taking all contex- other, they persist even with suspension. The aim of this work is
tual features into consideration in order to understand and address to present a case of a 67 years-old woman with a 10 years’ history
the underlying dynamics of the addictive behaviour as such. of Delusional Disorder who presented for the first time with axial
Disclosure of interest.– The authors have not supplied a conflict of corea, oromandibular dystonia, akathisia and left hand dystonia.
interest statement. Also to do a revision of the literature on the topic based on the
key-words “neuroleptic-induced; parkinsonism; drug-induced”.
Methods.– Patient assessed at Hospital de Cascais and clinical
E-PV0178 data from the hospital informatics system and subsequente non-
Neuropsychiatric symptoms in systematic review of the literature on the topic.
huntington’s disease- 5 case series Results.– The workup for the differential diagnosis of parkinsonism
M. Vedean1* , A. Oleleu1 , I. Dragomir2 , G. Scarisoreanu1 , C. causes was made after persistence of the symptoms in this patient.
Marginean1 Sometimes the dopaminergic blockers unmask a movement dis-
1 Emergency County Hospital Cluj Napoca Romania, Psychiatry I order and drug-induced parkinsonism overlaps substantially with
Ward, Cluj Napoca, Romania; 2 Private Practice, Psychiatry, Cluj Parkinson disease. The former diagnosis is supported by a highly
Napoca, Romania symmetrical presentation, a lack of gait and balance difficulties
* Corresponding author. and attenuation with dose reduction or discontinuation of antipsy-
chotic medication.
Background and aims.– Huntington’s disease is an autosomal dom- Conclusions.– It is very common for the patients to present with
inant neurodegenerative disorder characterized by a triad of movement disorders in neurology consultation after years under
symptoms consisting of cognitive impairment, motor disturbances treatment with neuroleptics. It is very important for the psy-
and psychiatric features. Studies have shown that psychiatric chiatrist to be able to identify these situations and to start the
manifestations often precede the motor signs of the disease by differential diagnosis work-up.
sometimes even more than a decade. Disclosure of interest.– The authors have not supplied a conflict of
This study aims to report a series of 5 patients with genetic diagno- interest statement.
sis of Huntington’s disease and to describe preclinical and clinical
neuropsychiatric manifestations.
Methods.– The authors reviewed medical records of 5 patients seen E-PV0180
in the psychiatric departments, and have used PubMed for a sys- Physical restraints in acute
tematic literature review on the topic. confusional syndrome patients
Results.– The 5 patients studied consisted of 2 males and 3 females A. Alonso Sanchez* , H. De la Red, A. Álvarez, M. Gómez, M. De
all with a family history of Huntington’s two of the patients Lorenzo, N. De Uribe, C. Capella, E.M. Rodriguez, I. De la Montaña,
being relatives (father and daughter). Aside from one patient J. Gonçalves, A. San Roman
who presented with juvenile Huntington’s disease and early onset Hospital Clínico Universitario de Valladolid, Psychiatry, Valladolid,
of choreiform movements and cognitive impairment all other Spain
4 patients presented with psychiatric pre-clinical manifestations * Corresponding author.
consisting of: insomnia, anxiety, depression, restlessness, irritable
mood and mild psychotic symptoms that much preceded the motor Background and aims.– Physical restraints are still used in non-
involvement of the disorder. psychiatric wards in some countries. We have tried to identify de
Conclusions.– Psychiatric symptoms are prevalent in Huntington’s possible causes with the aim of reducing these techniques.
and are relatively independent of the motor and cognitive symp- Methods.– Case report and bibliographic review.
toms of the disease and their progression. In the majority of the Results.– Liaison psychiatric service attention was required to eval-
cases psychiatric symptoms preceded the onset of the other symp- uate a 75-year old patient in the general surgery ward. He had been
toms by years. Gaining better understanding of the symptoms is operated for cholecystitis 24 hours before and at that moment he
essential as these have strong implications for disease manage- was suffering from restlessness, aggressivity towards the staff, anx-
ment, prognosis and quality of life. iety and delusions. He was staying in a 3-patient bedroom, he had
Disclosure of interest.– The authors have not supplied a conflict of no family with him and he did not understand how to ask for help.
interest statement. He was physically restrained to avoid self-harm and harm to others.
He was diagnosed with Acute Confusional Syndrome.
We prescribed pharmacological treatment with a low dose of
haloperidol and a non-pharmacological intervention consisting
E-Poster Viewing - 7–9 April: Consultation Liaison of close supervision by the staff, single bed bedroom and ade-
Psychiatry and Psychosomatics quate ambience light. With this new approach, the patient quickly
improved and no other physical restraints were needed.
Conclusions.– Physical restraints are generally overused in some
E-PV0179 countries due to the lack of an adequate training for the acute
confusional syndrome and lack of resources.
After years of delusional disorder, a
Health staff should always consider alternative approaches such
movement disorder: from a clinical us specialised psychopharmacological treatment and some non-
case to a revision on the topic pharmacological interventions with the aim to avoid the use of
M. Albuquerque* , D. Esteves de Sousa, M. Silva Costa, P. Cintra, J. physical restraints in a general hospital.
Tropa Disclosure of interest.– The authors have not supplied a conflict of
Hospital de Cascais, Mental Health Department, Lisboa, Portugal interest statement.
E-PV0181 Results.– A 76-year-old female was admitted to hospital with acute

Hereditary metabolic disorders lower back pain. For pain management she received two injec-
causing psychiatric symptoms, a tions of tramadol 100 mg intramuscular (I.M.), with an interval of
6 hours. After the second injection, the patient suddenly developed
diagnostic challenge an acute confusion, auditory hallucinations, delusions, and violent
A. Antunes* , D. Telles Correia
behaviour. She was sedated with lorazepam 2 mg I.M. and haloperi-
Centro Hospitalar Lisboa Norte, Psychiatry, Lisboa, Portugal
dol 2 mg I.M. There was no personal or family history of psychiatric
disorder or mental illness. Blood laboratory testing excluded any
Background and aims.– A number of hereditary metabolic disorders abnormalities. Neurological examination revealed no significant
(HMD) that affect the central nervous system can present in child- results. After psychiatric examination she was diagnosed with
hood or adulthood as a phenocopy of major psychiatric syndromes, tramadol induced delirium. Confusion, psychotic symptoms and
leading to incorrect primary psychiatric diagnosis. violent behavior resolved after discontinuation of tramadol.
The main objective of this work is to provide a better understand- Conclusions.– Although tramadol is a widely used analgesic for the
ing and awareness of secondary syndromes in metabolic disorders, treatment of moderate to severe pain, it should only be used after
which we considerer of great importance for the psychiatrists as careful consideration in older adults.
it can lead to an early diagnosis of HMD, with great impact in the Disclosure of interest.– The authors have not supplied a conflict of
course and prognosis, preventing permanent neurologic damage interest statement.
and allowing for genetic counseling.
Methods.– A literature review was conducted through the PubMed
E-PV0183
database examining all the systematic reviews published in the last
five years, which include all the clinical cases of HMD presenting Charles bonnet syndrome: a
with significant psychiatric symptoms that have been reported to prodromal stage of lewy body
the date. dementia?
Results.– Twenty HMD causing psychiatric symptoms were M.H.L. Arts1* , S. Petrykiv2 , L. de Jonge3
identified. We highlight the ones that are potentially treat- 1 Mental Health Care –Western North Brabant GGZ-WNB,
able: Urea cycle disorders, Homocysteine remethylation defects Department of Old Age Psychiatry and Neuropsychiatry, Halsteren,
and Cystathionine-synthase deficiency, presenting typically with The Netherlands; 2 MUMC, Department of Clinical Pharmacy and
confusion, behavioral changes and psychotic symptoms; Niemann- Pharmacology, Maastricht, The Netherlands; 3 Leonardo Scientific
Pick disease type C and Cerebrotendinous Xantomatosis and Wilson Research Institute, Department of Neuropsychiatry, Groningen, The
disease which main features are impulsivity and irritability. A sim- Netherlands
ple algorithm for the screening of metabolic disorders in cases with * Corresponding author.
atypical psychiatric presentations was also obtained.
Conclusions.– There is a group of metabolic disorders presenting Background and aims.–
with isolated neuropsychiatric symptoms, currently not identified Background.– Charles Bonnet Syndrome (CBS) is a disorder in older
by most diagnostic paradigms, that may be far more common than adults, and is characterized by a triad of recurrent vivid visual
we are aware. It is importante to be able to recognize them in hallucinations, ocular pathology causing visual impairment due to
cases with acute onset and atypical psychiatric presentations or lesions in central or peripheral visual pathways, and normal cogni-
with poor response to standard treatments. tive status. It is often misdiagnosed as a psychosis or a drug related
Disclosure of interest.– The authors have not supplied a conflict of condition. CBS was anecdotally reported as a prodromal stage of
interest statement. early dementia.
Aims.– To present a case report, describing CBS as a prodromal stage
of LBD.
E-PV0182 Methods.– A case report is presented and discussed, followed by a
Tramadol-induced delirium literature review.
M.H.L. Arts1* , S. Petrykiv2 , L. de Jonge3 Results.– An 68-year old female was admitted to hospital for per-
1 Mental Health Care –Western North Brabant GGZ-WNB, sistent vivid visual hallucinations. There was no past personal
Department of Old Age Psychiatry and Neuropsychiatry, Halsteren, or family history of mental illness. On neurological examination
The Netherlands; 2 MUMC, Department of Clinical Pharmacy and we observed discrete balance problems and rigidity, the patients
Pharmacology, Maastricht, The Netherlands; 3 Leonardo Scientific MMSE score was 25/30. Ophthalmological examination showed
Research Institute, Department of Neuropsychiatry, Groningen, The visual impairment due to age related macular degeneration. Treat-
Netherlands ment with antipsychotics proved not to be effective and instead
* Corresponding author. increased muscle rigidity. During the next months, we noticed pro-
gressive cognitive decline with other core features of LBS including
Background and aims.– fluctuating cognition with pronounced variations in attention and
Background.– Tramadol is a widely used centrally acting synthetic alertness, recurrent visual hallucinations, and spontaneous motor
opioid analgesic for the treatment of acute or chronic, moderate to features of parkinsonism.
severe pain. It has been associate with a wide range of side effects, Conclusions.– CBS is a rare disorder that may represent a prodromal
including mood changes, confusion, and occasionally psychosis. stage of LBD. However, there is some overlap in symptoms between
Cases of tramadol-induced delirium have been reported rarely. these two disorders, making a correct diagnosis difficult, particu-
Aims.– To present a case report of tramadol-induced delirium, fol- larly in early stages of dementia. In this study we describe that CBS
lowed by a literature review. may be a marker of a prodromal stage of LBD.
Methods.– An English language literature search was conducted Disclosure of interest.– The authors have not supplied a conflict of
using Pubmed and EMBASE searching for case reports and observa- interest statement.
tional studies reporting delirium due to treatment with tramadol.
E-PV0184 Psychiatric consultation is intended to improve the quality of

Case files in consultation-liaison patients care, and also to bring about an ethical imbalance in the
psychiatry: clinical pearls in the treatment of psychiatric patients.
Methods.– Clinical study.
management and treatment of Results.– The survey included patients who were examined by the
catatonia in the medically and psychiatrist during year of 2016. There were 1420 consultations. In
psychiatrically ill the period from 01.01. 2017 until 01.09.2017 there were 1023 con-
D. Banayan1* , A. Roman2 sultations. During the first eight months of this year, actually, in the
1 Rush University Medical Center, Psychiatry, Chicago, USA; 2 Clínica period from 01.01.2018–01.09.2018 there were 890 consultative
Universidad de Navarra- España, Departamento de Psiquiatría y reviews were carried out, at the other Clinics of the Clinical Center
Psicología Clínica., Pamplona, Spain of Montenegro. Medical documentation was used to monitor the
* Corresponding author. consultations, as well as the ICD 10 and WHO.
Conclusions.– There were an increase in the number of consulta-
Background and aims.– Catatonia is a complex clinical syn- tive examinations on some non-psychiatric departments. We can
drome that can be caused by primary psychiatric disorder, by conclude that the holistic approach to the patient is not neglected,
non-psychiatric medical problems, or by an interplay of these. and that the colleagues in somatic departments pay more attention
Treatment of catatonia in the medically ill poses unique chal- to the role of psychological factors in genesis and the resolution of
lenges such as diagnostic complexity and the risks posed by somatic diseases.
inter-current medical illnesses. Ethical problems arise in the treat- Disclosure of interest.– The authors have not supplied a conflict of
ment of catatonic patients is, perhaps, an under-appreciated and interest statement.
not-often-enough talked about problem. In this session, recent
advances in the understanding of catatonia, and treatment of the
condition are reviewed. Use of a clinical case series will serve as E-PV0186
the platform to facilitate the discussion. The session will include Transplantation and
interactive discussion and uses audience engagement to enhance
participation and learning.
psychopharmacology – what should
Methods.– A case series of four patients with catatonia who were we do when our patients are
assessed and treated by the psychiatric consultation services of two transplanted?
different academic hospitals, one in the United States and the other A.M. Bernardo1* , I. Pinto2
1 Hospital Garcia de Orta, Serviço de Psiquiatria e Saúde Mental,
in Spain.
Results.– Clinical outcomes for these cases will be discussed in Almada, Portugal; 2 Centro Hospitalar Psiquiátrico de Lisboa,
detail, including treatment response, and where available, long- Psiquiatria, Lisboa, Portugal
term follow-up outcomes.
Conclusions.– Catatonia is a syndrome that remains poorly under-
stood and is often not recognized at an early stage. Improving Background and aims.–
awareness and education about this syndrome is an important Introduction.– Patients with mental health disorders are a risk group
priority both for psychiatrists and other disciplines in medicine of multiple organic diseases, associated to high prevalence of non-
who interface with these patients earlier in the disease process. healthy behaviors and late search for medical care. Mental health
While ECT and benzodiazepine challenge are well-recognized to patients represent a population with increased risk of organ trans-
have potential therapeutic value in catatonia, other less known plantation. In case of an organ transplant, we could expect that
options and concurrent medical complexity add nuances that offer psychopharmacs need a medical review, due to hight probability
opportunities for learning and practice improvement. of iatrogenic, pharmacokinetic and pharmakodinamic issues.
Disclosure of interest.– The authors have not supplied a conflict of Objectives.– The purpose of this work is to review psychopharma-
interest statement. cology in patients with mental health disorders, when submitted
to organ transplantation.
Methods.– The authors revised the published literature about
E-PV0185 this topic, including the topic words “organ transplant”, “antide-
pressant”, “antipsychotics”, “anxiolytics” and “mood stabilizer” in
Team work to better health -
scientific date base. The relevant articles were selected and com-
consultative psychiatry plemented with information from medical books, non available
I. Ljutica, Z. Barac Otasevic* , S. Kalac on-line.
Clinical Center of Montenegro, Psychiatric Clinic, Podgorica, Results.– There is a heterogeneous approach to those patients and
Montenegro most of the information available is due to clinical cases. Some
of the challenging topics identified in clinical management relate
Background and aims.– Liaison psychiatry or consultative psychiatry is to changes in the metabolism and elimination of drugs during
the sub-specialty which provides psychiatric treatment to patients organ insufficiency, drug interactions, and overlapping side effects
attending general hospitals, whether they attend out-patient clin- between psychopharmacological and immunosuppressive drugs.
ics, emergency departments or are admitted to in-patient wards. One of the limitations found was the exclusion criteria of some
Therefore it deals with the interface between physical and psycho- organ transplant centers, which consider the presence of a mental
logical health. health disorder a total or partial contra-indication for treatment.
Consultative psychiatry is an important part of the treatment of Conclusions.– Organ transplant is still a recent medical procedure
patients in non-psychiatric departments. in constant upgrade, with limited information about psychophar-
The goal of this paper was to determine the departments where the macology in mental health patients.
most frequent psychiatric consultations were in order to improve Disclosure of interest.– The authors have not supplied a conflict of
the holistic approach by using consultative psychiatric examina- interest statement.
tions.
E-PV0187 Methods.– A case report is discussed.

The twisted mind-a case report of Results.– The rheumatologic symptoms (proximal muscle weakness
psychogenic dystonia of the lower limbs, with difficulties in climbing stairs, dermato-
S. Bhattacharya1* , S. Chatterjee Sekhar2 , S. Das3 , S. Gupta4 myositis “glasses”, Gottron’s papules and “machinist’s hand”) first
1 Derbyshire Healthcare NHS foundation Trust, Psychiatry, appeared a year before. From the heteroanamnesis, we learned
Chesterfield, United Kingdom; 2 Medical College- Kolkata- India, that the first psychiatric symptoms appeared simultaneously with
Psychiatry, Kolkata, India; 3 NIMHANS-Bangalore-India, Psychiatry, the inflammatory ones, with mild disinhibited behavior, slightly
Bangalore, India; 4 Burdwan Medical College-India, Psychiatry, elevated mood and self-esteem, logorrhea episodes, without affect-
Burdwan-West Bengal-India, India ing the quality of life of the patient or of his family. Nevertheless,
* Corresponding author. after methylprednisolone 16 mg/day initiation, they reached the
intensity of a severe manic episode with psychotic features. The
Background and aims.– Dystonia is rarely psychogenic, but this etiol- psychological exam showed: severe mania (YMRS = 42), QI = 98
ogy is suggested when clinical characteristics are inconsistent and (Raven test), cognitive dysfunction and schizotypal personality dis-
incongruous with a classical disorder. Within the realm of func- order (SCID-II). During the admission, the rheumatologist decided
tional movement disorder (FMD), functional dystonia is one of the the reduction of the dose of methylprednisolone to a minimum of
most common. Being in an interdisciplinary area and having the 8 mg/day and augmentation with azathioprine 100 mg/day, to favor
requirement of detailed examination, which is not in the standard the effect of the psychotropic therapy with quetiapine 800 mg/day
armamentarium of either neurologist and psychiatrists, misdiag- and valproate 1 g/day.
nosis and treatment failure is a common phenomenon; hence this Conclusions.– Both corticotherapy and systemic inflammation can
report. induce affective episodes, thus interdisciplinary communication is
Methods.– A thirteen year old male presented with progressively essential
increasing spasm and rigidity on the right side of his body. Patient Disclosure of interest.– The authors have not supplied a conflict of
was admitted to neurology where all routine imaging were per- interest statement.
formed and having come back normal, he was recommended
for detailed neurological examination. Seven days of treatment
with muscle relaxant and anticholinergics did not show any E-PV0189
improvement. Afterwards, observing the suggestibility, that it was Mindfulness moderates severity of
precipitated with stress, having nil investigation findings, the anxiety symptoms in psoriasis
patient was referred to psychiatry, where after a detailed clarifica- patients
tion of history, he was diagnosed with ‘Severe Depression without E. Parlapani1 , E. Mitsiou2 , D. Kirla1 , A. Patsatsi2 , G. Floros3 , I.
psychotic symptoms’. Hamilton depression scale (HAMD) score Diakogiannis1 , V. Bozikas3*
was 24, indicating very severe depression. Rorschach and Thematic 1 Faculty of Medicine, Aristotle University of Thessaloniki, 1st
Apperception Test revealed significant interpersonal conflicts and Department of Psychiatry, Thessaloniki, Greece; 2 Faculty of
internal stress. Patient was started on Escitalopram 10 mg and Clon- Medicine, Aristotle University of Thessaloniki, 2nd Department of
azepam 0.25 mg with intense, structured psychotherapy and family Dermatology and Venereology, Thessaloniki, Greece; 3 Faculty of
intervention. Medicine, Aristotle University of Thessaloniki, 2nd Department of
Results.– In the following 2 weeks the patient’s condition notably Psychiatry, Thessaloniki, Greece
improved. For the next two months he received follow up with no * Corresponding author.
recurrences.
Conclusions.– Our case highlights that closely watching clinical Background and aims.– Mindfulness is defined as “the state of being
manifestations, in-depth psychiatric screening, and improved mul- attentive to and aware of what is taking place in the present”.
tidisciplinary management are necessary for all cases of dystonia Higher mindfulness levels have been associated with less distress in
not responding to classical treatments. patients suffering from different dermatologic conditions. Psoriasis
Disclosure of interest.– The authors have not supplied a conflict of patients show a high prevalence of anxiety symptoms, associated
interest statement. with the severity of skin lesions. The present study focused on the
association between mindfulness and severity of anxiety symp-
toms in psoriasis patients.
E-PV0188 Methods.– Fifty-eight study participants were recruited from the
A manic episode with psychotic Psoriasis Outpatient Clinic of the 2nd Department of Dermatol-
features following corticotherapy for ogy and Venereology, Aristotle University of Thessaloniki, during
a 14-month period. Sociodemographic data, psychiatric and medi-
dermatomyositis
cal history were recorded based on a semi-structured interview and
M. Bonea1* , I.M. Parau2 , C.A. Crisan1
1 patients’ medical records. Psoriasis severity was evaluated by the
Iuliu Hat, ieganu University of Medicine and Pharmacy, Psychiatry,
Psoriasis Area and Severity Index, the Physician Global Assessment
Cluj-Napoca, Romania; 2 Cluj County Clinical Emergency Hospital,
and the Body Surface Area. Psychometric assessment included the
Psychiatry, Cluj-Napoca, Romania
* Corresponding author. Beck Anxiety Inventory (BAI) and the Mindful Attention Awareness
Scale (MAAS). Participants were divided into two subgroups based
Background and aims.– on the optimal BAI cut-off score.
Introduction.– Dermatomyositis is an idiopathic inflammatory dis- Results.– Psoriasis patients with more severe anxiety symptoms dis-
order of the connective tissue which affects the cutaneous and the played significantly lower mindfulness levels. In addition, anxiety
striated muscle cells. Systemic inflammation was correlated with a symptoms were significantly correlated with mindfulness levels,
high risk of psychosis and affective disorders, especially depression. a negative correlation. A stepwise regression analysis revealed
Corticotherapy used for the treatment of rheumatologic disorders that mindfulness contributed significantly to the calculation of BAI
can induce psychiatric symptoms ranging from severe depression score, explaining 23.4% of the variance.
to euphoria and psychosis. Conclusions.– There is a bidirectional relation between anxiety
Objectives.– To present the case of a 49 years old man, with no pre- symptoms and severity of psoriasis. As a result, a psychoder-
vious psychiatric history, admitted to the Psychiatry Clinic for a matologic approach is more beneficial for psoriasis patients.
manic episode after being diagnosed with dermatomyositis Mindfulness may moderate severity of anxiety symptoms. There-
fore, mindfulness-based interventions could improve psoriasis Conclusions.– Somatization is more likely to be found in depressed
global outcome. and/or anxious people and could have a screening value for these
Disclosure of interest.– The authors have not supplied a conflict of disorders. This however may be subject to the influence of cultural
interest statement. environment.
interest statement.
E-PV0190
Duloxetine in the treatment od
depression and irritable bowel E-PV0192
syndrome (IBS) Chest pain in childhood- when to stop
L. Damjanovikj1* , D. Peshevska2 testing and start listening?
1 JZU ZD Skopje- Skopje, Psychiatry, Skopje, FYR Macedonia; 2 El S. Chakrabarti, A. Datta*
pharma lek, Lek, Skopje, FYR Macedonia Child and Adolescent Psychiatry, Paediatric Liaison Team, London,
* Corresponding author. United Kingdom
Background and aims.– Depession and IBS are very common comor-
bidity. Background and aims.–
The aims of this study is to assesss the efficasy of duloxetine for Introduction.– 12-year child, experiencing episodic (2-10) daily
irritable bowel syndrome (IBS). sharp central chest pain for 3 months presenting to the Emergency
Methods.– Patient is a woman 62 year old with IBS with depressive Department of a multispecialty hospital. Numerous investigations
symptoms. The outcome measure is abdominal pain and depres- done revealed no physical cause. He was referred to the paediatric
sion. We used HAMD and Sheehan Disability Scale. The therapy psychiatry department for exploration of his symptoms.
period of 12 week with duloxetine 60 mg per day. Aims.– We demonstrate the value of child psychiatry service with
Results.– After 4 week of treatment the patient was in good con- young people afflicted with similar problems. This includes under-
dition for the first time in her life. After a period of 12 weeks the standing the physical health findings and incorporating them with
patient was with no pain, good quality of life, family functioning pre-existing core beliefs about illness within the ecology of the
and smile on her face. Duloxetine is associated with lowering the child.
pain, improvment of quality of life, family disability and depression. Methods.– This child had a thorough psychiatric assessment.
There was no evidence of any adverse drug events. Results.– Physical health examination revealed morbid obesity.
Conclusions.– This case report sugest duloxetine is effective at Psychiatric assessment revealed a history of bullying in primary
patients with depression and IBS. school; family history of nonspecific back pain in mother, mul-
Disclosure of interest.– The authors have not supplied a conflict of tiple medical conditions in father who is wheelchair bound and
interest statement. also awaiting bariatric surgery. In the session the child experienced
chest pain which started abruptly when talking about his school
and abated with maternal comfort and after the assessing child
E-PV0191 psychiatrist palpated his apex beat.
Depression, anxiety and somatization Conclusions.– From the history, medical workup and psychiatric
M. Daoud1* , M. Hamza2 , S. Bourgou1 , F. Charfi1 , A. Belhadj1 assessment, it was deemed that this chest pain was psychogenic
1 Mongi Slim Hospital, Department of Child and Adolescent in origin.
Psychiatry, Tunis, Tunisia; 2 Mongi Slim Hospital, Department of With ongoing therapy and school liaison, he experienced far fewer
Child and Adolescent Psychiatry, Tuins, Tunisia episodes with a reduction in the intensity of pain alongside losing
* Corresponding author. 5 kg weight.
Research suggests a higher level of somatic symptoms in obesity;
Background and aims.– Somatization is the tendency to experience highlighting this might lead to a more interdisciplinary approach
and communicate somatic symptoms that are unaccounted for by in assessment, reducing risk of over- investigation and validating
pathological findings but certain somatic symptoms can be part of the psychosocial component of illness for the families and young
anxiety and depression disorders. people.
Objectives.– to explore somatization in a sample of female adults in Disclosure of interest.– The authors have not supplied a conflict of
relation to anxiety and depression. interest statement.
Methods.– Mothers attending with their child, the child and ado-
lescent psychiatry department were recruited. Somatic complaints
were assessed via the Patient Health Questionnaire 15 (PHQ 15). E-PV0193
The Hospital Anxiety and Depression Scale (HADS) was used to High on serotonin
evaluate anxiety and depression. N. De Uribe Viloria* , M. Gomez Garcia, M. De Lorenzo Calzon, C.
Results.– Seventy-three mothers were selected for the study. A psy- Capella Meseguer, E. Rodriguez Vazquez, J. Goçalves Cerejeira, A.
chiatric history was found in more than half of the cases with Alonso Sanchez, H. De La Red Gallego, A. Alvarez Astorga, A. San
mainly post-traumatic stress disorder (26%). The mean score on Roman Uria, F. De Uribe Ladron de Cegama, S. Cepedello Perez
the HADS was 17,7 with an average of 9,3 on the anxiety subscale Hospital Clinico Universitario, Psychiatry, Valladolid, Spain
and 8,3 on the depression subscale. Mean score of the PHQ15 was * Corresponding author.
9,3 with 75,3% of the sample meeting criteria for moderate som-
atization disorder and for severe somatization disorder in 24,7% Background and aims.– Serotonin syndrome (SS) is a rare although
of cases. PHQ15 scores positively and significantly correlated with on the rise condition associated to the use of serotonin agonists. Its
the total HADS score as well as the anxiety and depression sub- diagnosis faces difficulties due to lack of knowledge and similarities
scale scores (p = 0,000 for all). When considering each PHQ15 item with other entities.
separately, scores on the “Fainting spells” weren’t associated nei- Our aim is to increase awareness about SS so as to improve diag-
ther with depression nor anxiety scores and “Shortness of breath” nosis and treatment.
was found to be associated only with depression subscale scores Methods.– We present a 78 year-old man admitted to the Intensive
(p = 0,028). Care Unit after being found unconscious on the floor near an empty
venlafaxine box. He has history of diabetes, alcohol dependence
and long-term depressive symptoms, and follows treatmmet with Methods.– 75 FA (defined as individuals who had consulted GP
venlafaxine, alprazolam, quetiapine, insulin and omeprazole. 15 times or more per year) of Italian primary care centers were
Physical and psychopathological shows high heart rate and blood enrolled and assessed by socio-demographic scale, SCID-5, global
pressure, restlessness and continuous head and extremities move- functioning (GAF), illness behavior and perceived health (IBI),
ments, disorientation, and dysarthria and incoherent speech. somatic comorbidity (CIRS).
Blood analysis shows haemoglobin 14’6, leukocytes 1988, platelets Results.– Most of the sample were females, middle aged, mar-
133000, creatinine 0’85, urea 4’1, GOT 772, GPT 126, bilirubin 2’4, ried or cohabiting, with low levels of education. One third of FA
pH 7’4, pCO2 47, pO2 31, ↓P, INR 1’26, TTPA 31’1 was low-functioning (GAF score <70), with no differences in the
Results.– Venlafaxine intoxication + toxic hepatitis + rhabdo- socio-demographic variables. About 70.3% reported a current SCID
myolysis + hypokalaemia ≈ Serotonin syndrome. diagnosis, in particular major depressive disorder, somatic symp-
Conclusions.– Serotonin syndrome is an iatrogenic entity secondary tom disorders, and panic disorder, all being more frequent in
to the use of serotonin agonists, usually involving interactions at low-functioning (LF) patients. Half were taking a psychopharma-
therapeutic dosage between SSRIs/SNRIs and other pharmacolog- cological therapy, mostly benzodiazepines.
ical groups. It consists in mental, autonomous and neuromuscular Conclusions.– The surprisingly high rate of psychopathology may
changes (Figure 1). allow us to classify FA as a special population affected by a
mild-moderate severity of mental illness, and treated chronically
with benzodiazepines. Low-functioning FA perceived themselves
as more impaired regarding the health perception and social role.
In the light of these findings, educational initiatives should be
undertaken, aiming to increase doctors’ and patients’ confidence
in psychological support, as well as to sustain cooperation and the
referral system between general practitioners and psychiatrists.
interest statement.
E-PV0195
Relation of creatinine level to
depression in hemodialysis patients
O. Farajli
Ministry of Health, Male Clinic, Baku, Azerbaijan
Background and aims.– This study aims to investigate the relation-

Figure 1. Serotonin syndrome. ship between increase in creatinine levels of patients receiving
hemodialysis and emergence of depressive symptoms in these
Differential diagnosis includes anticholinergic syndrome, malign patients
neuroleptic syndrome and malign hyperthermia. Methods.– The DASS 21 is a 21 item self report questionnaire
Management consists in anti-serotonin drugs (ciproheptadine) designed to measure the severity of a range of symptoms common
plus symptomatic treatment. to both Depression and Anxiety. In completing the DASS, the indi-
Disclosure of interest.– The authors have not supplied a conflict of vidual is required to indicate the presence of a symptom over the
interest statement. previous week.
Results.– As demonstrated by our findings, among 40 hemodialysis
patients involved in the study, a relationship between levels of cre-
E-PV0194
atinine and severity of depressive symptoms exists. In other words,
Frequent attenders in the general it was observed that the higher the level of creatinine, the higher
practice in Italy: a preliminary report the severity of depressive symptoms (table 1).
on clinical variables related to low Table 1 The study on relationship between levels of creatinine and
functioning severity of depressive symptoms
V.Dell’oste1* ,C. Carmassi1 , D. Ceresoli1 , E.Diadema1 , A. Cordone1 ,
S. Moscardini2 , E. Bianchi3 , R. Landi4 , G. Massimetti1 , C. Nisita1 , L. Cretaine Number Normal Mild Moderate Severe Extremely
Dell’Osso1 level severe
1 University of Pisa, Department of Clinical and Experimental
400–600 10 8 1 1
Medicine, Pisa, Italy; 2 General Medicine Outpatient Clinic, Asl 5 600–800 21 13 6 2
Tuscany, Pisa, Italy; 3 General Medicine Outpatient Clinic, Asl 6 800–1200 9 2 4 3
Tuscany, Livorno, Italy; 4 General Medicine Outpatient Clinic, Asl 2
Tuscany, Lucca, Italy
* Corresponding author. Conclusions.– The reason for this research is to investigate depres-
sive symptoms in hemodialysis patients. Other similar studies on
Background and aims.– Frequent Attenders (FA), defined as patients this topic have identified that severity of depression among such
reporting a disproportionate number of visits to General Praction- patients is high. The main challenges for this study are low number
ers (GP), may represent up to a third of GP patients responsible for of participating patients and lack of information on monthly cre-
a high burden of care not always justified by the severity of the atinine levels. Although these limitations influence our findings,
medical condition. calculated figures lead to us conclude that the results are reliable.
The aim of this study was to explore socio-demographic and clin- Disclosure of interest.– The authors have not supplied a conflict of
ical characteristics of FA of GP in Italy with particular attention to interest statement.
functional impairment.
E-PV0196 underlying synucleinopathy, which persists after antidepressant

Sexual functioning in a sample of withdrawal.
Conclusions.– The interaction between depression, antidepressants
obese and overweight Tunisian
and RBD is complex and requires further investigation. Dream-
women enactment behaviour occurring with antidepressants may be an
R. Feki1 , R. Damak2 , T. Naceri2 , S. Smaoui1 , A. Feki2* , M. Cheour2 , early sign of a neurodegenerative synucleinopathy.
H. Jamoussi3 Disclosure of interest.– The authors have not supplied a conflict of
1 Medical School, Psychiatry, Sfax, Tunisia; 2 University Tunis El
interest statement.
Manar, Psychiatry, tunis, Tunisia; 3 University Tunis El Manar,
Nutrition, Tunis, Tunisia
E-PV0198
Background and aims.– Background: Obesity is a major public health Skin stress? - A psychocutaneous
in Tunisia. Prevalences of obesity and overweight are respectively disease case report
12.3% and 21.8% (8.9% in men, 12.8% in women). Studies in women B. Guedes* , A. Silva, E. Monteiro, A.L. Costa
assessing female sexual function index (FSFI) and body weight are Tondela-Viseu Hospital Centre, Department of Psychiatry, Viseu,
limited. Portugal
Aims: We aimed to assess sexual function in obese and overweight
female women.
Background and aims.– Psychocutaneous diseases can be described
Methods.– We conducted a cross sectional study from Mars to
as primary psychiatric diseases with cutaneous manifestations, but
Septembre 2018 among outpatients referring to the centre for the
it is well known that a psychiatric illness may either be the cause
care of obesity in the national institute of nutrition. Fifty female par-
or the consequence of a dermatologic disease. Underlying psy-
ticipants with a body mass index (BMI) ≥25 were recruited. Medical
chiatric conditions are estimated to occur in up to one third of
history, obesity-related complications and medication use, as well
dermatologic patients. On the other hand, dermatological adverse
as demographic, social information were obtained. We used The
effects of psychiatric medications are known; despite this, the
FSFI to assess sexual function.
anti-inflammatory properties of antidepressants are increasingly
Results.– The mean age was 38.5 years. Among participants 12%
recognized and can be used with benefits in dermatological condi-
were illiterate, 46% had low socio-economic level, 94% were
tions.
married, 64% had no chronic illness and 72% wasn’t under any
Our aim was to review the literature on the relationship between
medication. Six women suffered from amenorrhea. We noted
psychiatric dermatological pathologies, to discuss the potential
a smonking habit in 10% of participants. Eleven women were
mechanisms of stress induced dermatological disease. To present a
overweight and 39 were obese. The mean BMI was 37.02 ± 8.75.
brief clinical case of alopecia areata associated with an adjustment
The mean FSFI score was 27.41 ± 6.18. There was no correlation
reaction.
between FSFI score and the BMI.
Methods.– A research of the literature on the subject was conducted
Conclusions.– Obesity and overweight seemed to be not a brake on
using Pubmed® online search engine taking into account the key-
sexuality in our context.
words: Psychodermatology, psychocutaneous disorders.
Results.– Case Report: Male, aged 34, referred to the psychiatry
interest statement.
consultation due to alopecia areata refractory to all dermatological
treatments. From the organic point of view, no infectious, inflam-
E-PV0197 matory or degenerative causes were found. Psychiatric evaluation
was characterized by anxious and depressive symptomatology,
Rem sleep behaviour disorder reactive to an affective rupture and mother’s prolonged illness. An
associated with antidepressants – an SSRI was started. Current investigations actually show that skin is a
independent entity or a prodrome of target of distress, as well as an active participant of stress response,
neurodegeneration? and both pharmacological and psychological interventions can be
C. Fragoeiro* , L. Monteiro, B. Almeida, C. Machado, P. Moura used to help treating psychocutaneous disorders.
Ferreira Conclusions.– Given the difficulty in characterizing skin lesions and
Hospital Magalhães Lemos, Psychiatry department, Porto, Portugal the subjectivity of psychopathology, psychocutaneous diseases can
* Corresponding author. be difficult to recognize and interpret.
Background and aims.– Reports of disrupted sleep are extremely interest statement.
frequent among patients suffering from depression, and are con-
sidered one of the diagnostic criteria for this disorder. Depression
itself alters the architecture of sleep, as do the antidepressants pre- E-PV0199
scribed for treatment. Some antidepressants even worsen or induce The role of consultation-liaison
primary sleep disorders, such as REM sleep behaviour disorder
psychiatry services in patients with
(RBD).
RBD is a strong prodromal marker of synuclein-mediated neurode- self-inflicted burns: a five-case series
generative diseases such as Parkinson’s Disease (PD). It is crucial and a review of current literature
to understand whether antidepressant-associated RBD is an inde- S. Gunturu* , V. Liz Defillo
1 Bronx Care Health System, Psychiatry, New York, USA
pendent entity or a sign of possible prodromal neurodegeneration,
which is what we aim to analyse.
Methods.– An extensive Pubmed search with the terms “antide-
Background and aims.– Self-inflicted burns encompass a range of
pressants”, “depression”, “REM sleep behaviour disorder”, “synu-
deliberate self-harm behaviors involving burns with the intent to
cleinopathy”, “Parkinson”, “Lewy body” and “multiple system
self-mutilate or to attempt suicide (1). The National Burn Repos-
atrophy” was performed. Abstracts were read and relevant articles
itory (2006-2015) estimated that 1% of burn injuries were due
in English with available full text were considered.
to suspected self-inflicted burns (2). Multidisciplinary teams are
Results.– Studies suggest that antidepressants may unmask a
required to manage such complex cases (3). We aim to describe
previously subclinical loss of REM sleep atonia due to an
the collaborative role of a consultation-liaison psychiatry team at a E-PV0201

burn unit in managing patients with self-inflicted burns as suicidal Do alexithymia and anxiety increase
attempts.
the risk of the heart diseases?
Methods.– Electronic data searches of PubMed, Medline, and the
M. Janowska1* , A. Czernikiewicz2 , H. Karakuła-Juchnowicz1
Cochrane Library (years 1990–2017) were performed using key- 1 Medical University, I Department of Psychiatry- Psychotherapy and
words: “burn”, “self-immolation”, “suicide”, and “self-inflicted
Early Intervention, Lublin, Poland; 2 Marie Curie Skłodowska
burns”. The authors, in consensus, selected pivotal studies and con-
University, Department of Speech and Language Therapy and Applied
ducted a narrative review of fifteen clinical studies.
Linguistics, Lublin, Poland
Results.– Five cases of suicide attempts by self-inflicted burns * Corresponding author.
treated at a verified burn center were reviewed. Four of these were
male. The reported body surface area burned ranged from 23 to 70 Background and aims.–
percent. The mean length of stay in the hospital, including acute Introduction.– According to the M. Bleuler’s classification, coronary
care and rehabilitation, was 99.18 days. All cases met criteria for at heart disease and hypertension are defined as the psychosomatic
least one psychiatric diagnosis with a substance use disorder. Delir- disorders. Apart from genetic and environmental factors which
ium was a complication for all cases at the beginning of the hospital lead to development of the cardiovascular diseases, psychological
stay. Multiple sub-specialized teams were required to provide opti- causes (including anxiety and alexithymia) also play a crucial role.
mal patient care. The aim of the research.– The aim of the research was to evaluate the
Conclusions.– It is vital to raise awareness about intentional self- influence of the experienced level of alexithymia and co-ocurrence
inflicted burns as an understudied high-risk method of self-injury of alexithymia and anxiety of the heart diseases.
in patients with mental illness. To effectively and safely treat Methods.– The research involved 140 adolescents, with heart dis-
patients with self-inflicted burns, consultation-liaison psychiatrists eases: hypertension and hypertension with stable or unstable
should collaborate with other team members in the treatment of angina. Questionaires TAS—20, STAI were used to collect data.
these patients adverse emotional and physical injuries. Results.– The average level of alexithymia in population was 55,06
Disclosure of interest.– The authors have not supplied a conflict of while the group of patients with hypertension scored 54,88 (p
interest statement. value = 0,767). Patiens with heart disease scored 56,24 and 54,26
(stable vs. unstable angina). During the assesment of occurence of
alexithymia and the “anxiety as a state” and “anxiety as a trait”
E-PV0200 statistically significant positive linear correlation was found (for
Evaluation of impulsivity and the both p value <0,0001, r = 0,484 and r = 0,563). In both analyses the
relationship between affective strongest correlation was found among the patients with hyper-
symptoms and impulsivity in patients tension.
Conclusions.– No link between alexithymia level and development
with epilepsy of heart disease was noted. Coincidence of alexithymia and anxiety
S. Işık-Ulusoy1* , B. Horasanlı2
1 was related to the severity of symptoms of cardiovascular diseases.
Başkent University Faculty of Medicine Konya Research Hospital,
Psychiatry, Konya, Turkey; 2 Başkent University Faculty of Medicine
interest statement.
Konya Research Hospital, Neurology, Konya, Turkey
E-PV0202
Background and aims.– It is well known that impulsivity is associ-
ated with many psychiatric disorders. There are limited data in the Aspirin abuse (salicylism) – case
literature about impulsivity in patients with epilepsy and addition- analysis
ally these patients have increased risk of suicide and psychiatric K. Kaufman* , A. Rehan, D. Goldrich, A. Sreedhar, A. Tobia, A.
comorbidities. The aim of this study to evaluate impulsivity and Trenton
the relationship between affective symptoms and impulsivity in Rutgers Robert Wood Johnson Medical School, Psychiatry, New
patients with epilepsy. Brunswick, USA
Methods.– In this cross sectional study 26 epileptic patients * Corresponding author.
with generalized tonic clonic seizure and age, sex and education
matched 20 healthy controls were enrolled. To determine partici- Background and aims.– Over-the-counter (OTC) medication abuse
pants’ affective symptoms Hospital Anxiety and Depression Scale is a prevalent problem which increases the risk of unintentional
(HADS) was used and Barrat Impulsiveness Scale-11 (BIS-11) was overdose, medical complications, emergency department (ED) pre-
performed for assessment of impulsivity for all subjects. The results sentation, and hospitalization. This case describes a patient with
were analyzed using SPSS-25. Differences between groups were chronic aspirin abuse who presented to the ED with salicylate
evaluated using ANOVA and Student’s t tests. intoxication (salicylism) and endorsed elation secondary to delib-
Results.– The study involved 26 patients with epilepsy and 16 erate aspirin consumption.
patients had affective symptoms. Patients with epilepsy showed Aim.– Expanding clinicians’ index of suspicion regarding potential
higher scores on two subscales of BIS-11(motor impulsivity (p: OTC medication abuse, including aspirin, with psychoactive effects.
0.039) and non planning impulsivity (p < 0.001)) and total score Methods.– Case analysis.
of BIS-11 (p < 0.001). Epileptic patients with affective symptoms Results.– 49-year-old male with no significant past medical his-
showed higher scores on attentional impulsivity subscale of BIS-11 tory presented with ataxia/lethargy/confusion to the ED after
than epileptic patients without affective symptoms and controls. ingesting unknown quantity of aspirin. Past psychiatric history
(respectively p: 0.015; p: 0.036). included schizoaffective disorder, Tourette’s syndrome, multi-
Conclusions.– Impulsivity may be predictive for suicidality in ple suicide attempts (overdoses), and polysubstance dependence.
patients with epilepsy. Therefore, diagnosis and treatment of All standard laboratories were within normal limits except for
impulsivity in these patients is important in terms of increasing CO2 19.2 mmol/L, anion gap 13 mEq/L, and blood salicylate level
the patients’ quality of life. 43 mg/dL. Lithium level was 0.84 mEq/L; acetaminophen level and
Disclosure of interest.– The authors have not supplied a conflict of urine toxicology were negative. Psychiatric consultation noted
interest statement. delirium (Folstein = 19/30) without depressive/manic/psychotic
features. He acknowledged receiving OTC tablets from another
patient at his day program “for a buzz.” Within 48-hours, his
symptoms, including delirium and elation, had resolved. Prior bines physical, mental and social components. The new Chaban’s
medical records noted a similar admission 5-months earlier for sali- Quality of Life Scale (CQLS) been developed and validated in the
cylism (blood salicylate level 59 mg/dL, CO2 18.3 mmol/L, anion gap healthy volunteers. We evaluated the quality of life of psychoso-
18 mEq/L) in which he admitted taking OTC medication because it matic patients with anxiety-depressive disorders on a scale (CQLS).
made him “feel good.” Methods.– 63 patients (mean age 46.7 years) with psychoso-
Conclusions.– OTC medication abuse may occur in monitored matic diseases, arterial hypertension, coronary heart disease) and
settings, in this instance intentional salicylate intoxication. Stan- anxiety-depressive disorders (F41.2) were twice assessed on the
dardized/comprehensive screening for OTC medication abuse 10-items scale CQLS (at the baseline and at the end of treatment -
should lead to early treatment, minimize analgesic abuse complica- 21 day), with an interval of 0-100 points.
tions, reduce ED presentations and hospitalizations, and decrease Results.– At the beginning of the study, quality of life was 57.3
morbidity and mortality. Clinician/patient education is required. points, which corresponded to a low level of quality of life. After
Disclosure of interest.– The authors have not supplied a conflict of treatment, the quality of life was 74.5 points (average level). The
interest statement. most sensitive items were physical condition, mood, everyday
activity and general satisfaction with life. Items of social activity,
financial well-being, living conditions remained unchanged. The
E-PV0203 Cronbach’s ␣ coefficient was 0.903 in CQLS. The correlation coeffi-
Consequences of psychosocial factors cient between tests and repeated tests confirmed the reliability of
on the treatment efficiency of CQLS (r = 0,918; p < 0,001).
Conclusions.– Short-term treatment of psychosomatic patients
diabetes mellitus type 1 and type 2
with anxiety-depressive disorders improves their quality of life
O. Khaustova* , A. Kogut
(p < 0.005), but changes relate only to individual items. The CQLS
Bogomolets National Medical University, Medical Psychology-
scale has proven acceptable reliability and validity, which allows
Psychosomatic Medicine and Psychotherapy, Kiyv, Ukraine
* Corresponding author. us to recommend it for further use.
Background and aims.– The most common problem in patients with interest statement.
diabetes mellitus (DM) type 1 (DM1) and type 2 (DM2) is lack of
compliance. Therefore, glycemic control largely depends on treat-
ment adherence. E-PV0205
The factors of improvement of DM patients’ treatment efficiency Prevalence of functional
was studied. gatrointestinal diseases (FGID) and the
Methods.– Study population (n = 60) consists of: comparable groups comparison of psychological
(CG) with DM1 (n = 16), DM2 (n = 33) and newly diagnosed DM.
symptoms according to the presence
Study data consists of demographic data, including: Medication
Compliance Scale (MCS), Holmes and Rahe Stress Scale (HRSS), of FGID in psychiatric out-patients at a
Dysfunctional attitudes Scale (DAS), Toronto Alexithymia Scale university hospital
(TAS-20), The Depression, Anxiety and Stress Scale (DASS-21) and S.Y. Lee1* , L. Hye-Jin2
1 Professor and Psychiatrist, Psychiatry and Mental Health, Iksan,
Chaban Quality of Life Scale (CQLS). Glycemic control was assessed
by glycosylated hemoglobin (HbA1c) results. The statistics analy- Republic of Korea; 2 Wonkwang University Grauate School, Public
sis has been performed using descriptive statistics and Pearson’s Health, Iksan, Republic of Korea
correlation with SPSS Statistics 22.0.
Results.– Statistically significant difference was found, according
to MCS: in patients with high (HC), middle (MC) and low level of Background and aims.–
compliance (LC). HC had higher rates according to CQLS on the Objective.– This study investigated the prevalence of functional
level (p = 0,004) and low rates of the DAS, TAS-20, DASS-21 and gastrointestinal disease (FGID) and comparison of psychological
HRSS results (p = 0,0001). LC had a higher level of HbA1c (M = 13 symptoms according to the presence of FGID in psychiatric out-
SD:1 vs. MC M = 9.83, SD:1.4 vs. HC M = 9, SD:1.4). The average val- patients at a University Hospital.
ues according to MCS: DM1 (M = 19), DM2 (M = 18) present MC; Methods.– The study was conducted with a total of 170 outpatients
by HbA1c: DM1 (M = 10), DM2 (M = 10) have identical indicators. visiting the Mental Health Department at a University Hospi-
Therefore, no statistically significant difference was found between tal. After excluding 26 patients due to unreliable responses, the
CG. remaining 144 patients were included in the data analysis. FGID
Conclusions.– The level of glycosylated hemoglobin is a sensitive was identified in accordance with the Rome III questionnaire -
marker of adherence to the treatment of patients with diabetes, Korean version. Demographic factors were recorded, and psychoso-
regardless of its type. cial factors were evaluated using the Hospital Anxiety Depression
Disclosure of interest.– The authors have not supplied a conflict of Scale (HADS), Patient Health Questionnaire-15 (PHQ-15), Child-
interest statement. hood Trauma Questionnaire-Korean (CTQ-K), and State-Trait Anger
Expression Inventory (STAXI). Chi-squared test, one-way ANOVA,
Student’s t-test and the Pearson’s correlation coefficient was used
E-PV0204 as statistical analysis methods.
Results.– The prevalence of FGIDs of psychiatric out-patients at
Chaban’s quality of life scale in
a university hospital was 43.7%. Among FGIDs, gastroesophageal
psychosomatic patients with reflux disease (GERD) was 44.4%, functional dyspepsia(FD) was
anxiety-depressive disorders 20.1%, functional constipation was 18.1%, and irritable bowel syn-
O. Khaustova* , O. Chaban drome (IBS) was 16.7%. The groups defined by the presence of FGID,
Bogomolets National Medical University, Medical Psychology, non-FGID showed no differences in demographic data. In terms of
Psychosomatic Medicine and Psychotherapy, Kiyv, Ukraine differences by psychiatric disorder classification, only IBS showed
a significant effect of psychiatric disorder (2 = 11.408, p = 0.022).
The psychiatric out-patients with GERD, IBS, and FD showed higher
Background and aims.– The quality of life of psychosomatic patients
depression, anxiety, somatic symptoms, and state-trait anger.
is the most sensual marker of the cure effectiveness, which com-
Conclusions.– This study found that patients with psychiatric disor- in the transplant waiting list, requires a previous psychiatric eval-
ders had a high prevalence of FGIDs, and psychiatric out-patients uation of candidates.
with FGIDs showed higher psychopathology. These results suggest The aim of present study is to examine the psychosocial character-
that FGIDs could be evaluated and managed for the treatment of istics of a group the patients candidates to a lung trasplant and the
psychiatric out-patients. outcome two years post trasplant.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– The patients, older than 18 years, who were included in
interest statement. the 2016 waiting list.
Results.– A total of sixty nine people (33 women and 39 men)
(49.2years SD 14.5). 55% were smoker in the past (minimum 6
E-PV0206 months of abstinence previous for inclusion) Only eigth individ-
Clinical profile of inpatients referred uals wasn’t transplanted. In the actually thirteen individuals have
to a consultation-liaison psychiatry died. Before the transplant, were taking antidepressants the 25%.
One patient presented a Bipolar Disorder.
service in a general hospital in Chile
Conclusions.– Our participation in this clinical program is proving
J. Libuy
that this patients require a mental approach and in sometimes a
Pontificia Universidad Católica, Psiquiatría, Santiago, Chile
* Corresponding author. follow up by the liason psychiatrist.
Background and aims.– Specific models of cooperation in the interest statement.
form of consultation-liaison service between specialised psychia-
try departments and other medical departments play a crucial role
in providing care to patients. The aim of these work is described the E-PV0208
characteristics of consultation-liaison psychiatry (CLP) services in Prevalence of long qtc in acute
a general hospital in Chile, and to determine the possible changes inpatients treated with psychiatric
of the clinical practice. drugs
Methods.– Data were collected retrospectively with standard- G. Simon1 , A. Alomar1 , I. González1 , X. Elizondo1 , M. Madre1,2*
ized operating procedures on consecutive inpatient consultation 1 Hospital Benito Menni CASM, Psychiatry, Sant Boi de Llobregat,
requests to the Dra. Eloisa Díaz Hospital in La Florida CLP service in Spain; 2 FIDMAG Research Foundation, Psychiatry, Sant Boi de
Chile in 4-year-period. Llobregat, Spain
Subsequently, the relevance of these was reviewed and a model of * Corresponding author.
inter-consultation management was proposed.
Results.– The most frequent psychiatric diagnoses were suicide Background and aims.– QT interval prolongation in the electrocar-
attempts, delirium and substance use disorder. The majority of diogram (EKG) is considered a cardiac risk factor. Long QT syndrome
patients were treated with psychopharmacologic drugs. There has can be caused by most antipsychotics and some antidepressants.
been an increase in the number of CLP per year, mainly due to sub- The aim is to investigte the prevalence of long QT in inpatients
stance use disorders. In order to improve the cost-effectiveness of admitted to the acute unit of Benito Menni Complejo Asistencia en
the service, was decided to propose inclusion criteria to determine Salut Mental (Sant Boi de Llobregat, Barcelona).
the need for a psychiatric evaluation of the patient. We hypothesized that acute inpatients are treated with higher
Inclusion criteria: doses of psychiatric drugs and risk of suffering cardiac side effects
- Severe decompensated psychiatric disorder increases.
- Psychotic episode Methods.– In a cross-sectional study we investigate the prevalence
- Manic / hypomanic episode of long QT in inpatients treated with psychiatric drugs during 7
- Catatonia months (February -August 2018).
- Severe withdrawal syndrome Two trained medical doctors calculated the QTc using the Bazett
- High risk of heteroaggression formula (QTc = QT / square root of RR). A QTc value > 450 ms was
- Neuroleptic malignant syndrome or serotoninergic syndrome considered a potential risk of developing arrhythmias, with the risk
- Intoxication by psychotropic drugs without altered mental state being elevated when QTc is > 500 ms.
A referral model is also proposed for those patients who do not We identified patients with a QTc > 440 ms.
meet these criteria. Results.– 325 inpatients were studied: 139 women and 186 men,
Conclusions.– It is important to optimize human resources in the mean age was 42 years (18-89, SD:14).
public health service. To improve the cost-effectiveness of liaison 19 (5,8%) had a QTc > 440 ms. No patients had a QTc superior of
psychiatry, we have to make an adequate prioritization and, in 500 ms.
this way, provide better care to patients who require who require Patients with long QTc were treated with: Venlafaxine (N:9), Olan-
psychiatric help more urgently. zapine (N:6), Quetiapine (N:3) and Clomipramine (N:1).
Disclosure of interest.– The authors have not supplied a conflict of Preventive measures to avoid arrhythmias were: dose drug reduc-
interest statement. tion, change of treatment, frequent EKGs assessments.
Conclusions.– The prevalence of long QTc in our sample was similar
to the general population.
E-PV0207 Baseline EKG and medical history can help doctor to identify
Liason psychiatry and lung patients with long QT and undertake preventive measures.
transplantation program Disclosure of interest.– The authors have not supplied a conflict of
M. Lopez interest statement.
Hospital Vall Hebron, Psychiatry, Barcelona, Spain
Background and aims.– The patients concerning pre and post lung
transplant, present significant rates of especific psychiatric disor-
ders. Our hospital has the lung transplant unit, where are attended
the patients of Catalonian and Baleares. The protocol to be included
E-PV0209 Conclusions.– There is currently limited literature which explores

Perceived burden and quality of life this association with most publications limited to case reports on
for family caregivers of patients with individuals. This is a rare outcome of a general anaesthetic however
we are able to suggest some risk factors which may increase the risk
type 2 diabetes of developing a functional neurological disorder. There is a need
N. Messeddi1* , A. Bejar1 , F. Hadj Kacem2 , F. Charfeddine1 , L. Aribi1 ,
for larger scale studies within this area to elucidate this association
M. Abid2 , O. Amami1
1 Hédi Chaker university Hospital, department of psychiatry B, sfax,
further and understand the aetiology and ability to predict these
episodes.
Tunisia; 2 Hédi Chaker University Hospital, Department of
Endocrinology, Sfax, Tunisia
interest statement.
Background and aims.– Diabetes has an impact on the patient’s life,

E-PV0211
but how can it affect the quality of life of their caregivers?
Objectives: To evaluate the burden among family caregivers of The role of quetiapine in protection of
patients with type 2 diabetes, and their quality of life (QOL) while neurodegeneration after traumatic
highlighting the factors associated. brain injury
Methods.– a cross-sectional, analytical study of 30 caregivers of type J. Morra, A. Alao
2 diabetic patients hospitalized in the endocrinology department SUNY Upstate Medical University, Psychiatry, Syracuse, USA
during the month of August 2018. * Corresponding author.
Zarit scale: to assess the level of burden and SF36 questionnaire: to
evaluate the QOL. Background and aims.– Schizophrenia is a chronic psychotic disor-
Results.– the average age of diabetic patients was 59.83 years old. der in which patients experience positive and negative symptoms
The average age of their caregivers was 44.83 years. Their sex ratio for over 6 months. Schizophrenia is associated with early mortal-
was 0.3 (8 M/ 22 W). These latter were unemployed in 46.7% and ity, with 40% of this excess mortality due to suicide (Hor & Taylor,
have a moderate socio-economic level in 60%. We find a conflict- 2010). This is a case of patient with schizophrenia who was treated
ual marital relationship in 27.3%. They presented a chronic somatic with quetiapine after suffering a traumatic brain injury (TBI) and
diseases in 50% The average burden score was 37.30 ± 16.39. The recovered enough to be discharged to a rehabilitation unit. Here the
daily load was moderate in 30% of cases. The burden was per- neuroprotective effects of quetiapine in treating neurologic deficits
ceived as severe among 10% of caregivers. The mean QOL score in a patient who recently suffered a TBI are observed and analyzed.
was 65.21 ± 21.62, 40% of caregivers had an impaired QOL. The fac- Methods.– This is a case report of a patient with schizophrenia who
tors correlated with the burden: moderate socio-economic level was placed on quetiapine after suffering a TBI due to a suicide
(p = 0.041) and conflictual marital relationship (p = 0.039). The fac- attempt in which he shot himself with a nail gun. This report is
tors correlated with the impaired QOL: moderate burden (p = 0.019) meant to describe and expound upon the treatment the patient
and a chronic somatic diseases (p = 0.015). received.
Conclusions.– Our study shows that diabetes affects the quality of Results.– The patient initially presented with neurologic deficits
life of caregivers, especially if it is perceived as a burden. Better typical of TBI (inattention, memory loss, muscle weakness) and
support is necessary of the latter. psychosis from schizophrenia. He was treated with quetiapine and
Disclosure of interest.– The authors have not supplied a conflict of recovered enough to be discharged to a rehabilitation unit.
interest statement. Conclusions.– Quetiapine, a second-generation antipsychotic, has
been shown to significantly decrease blood brain barrier hyper-
permeability by preserving tight junction integrity in small animal
E-PV0210 models (Robinson et al., 2018). This anti-inflammatory effect may
Conversion disorder after general also help to preserve neurogenesis in TBI patients, as shown in
this case. This case may help elucidate the nature of quetiapine’s
anaesthetic - a critical review
neuroprotective effects in patients who have suffered TBI, but also
D. Mirfin, A. Shuman
highlights the need to further investigate other atypical antipsy-
Surrey and Borders Partnership NHS Foundation Trust, Liaison
chotics and their potential neuroprotective role in treating TBI.
Psychiatry, Chertsey, United Kingdom
interest statement.
Background and aims.– General anaesthetic is known to imme-
diately precede Conversion Disorder. We describe a clinical case
vignette to illustrate this and then reviewed the literature to evalu- E-PV0212
ate the evidence with the aim of developing a better understanding Central coherence in eating disorders
of the underlying aetiology and frequency of these events. V. Muñoz Martinez* , B. Mata-Saenz, T. Rodriguez-Cano, L.
Methods.– We conducted a literature search using electronic Beato-Fernández
databases and reference list exploring the associations between Hospital General Universitario de Ciudad Real, Psychiatry, Ciudad
conversion disorders or functional neurological disorders and gen- Real, Spain
eral anaesthetics.
Results.– There was limited literature exploring this relationship
despite general anaesthetic being known to be a common trigger Background and aims.– We can divide central coherence into
to an episode of a functional neurological disorder. The publica- a cognitive component (metaphor comprehension and general
tions that were present seemed to focus on specific medications or information memory) and another perceptive (visual global prose-
the use of therapeutic sedation as a method to resolve a functional cution). Global processing has been affected in different disorders
episode. There were many case reports discussing this association as eating disorders with inconsistency in these results according to
however limited larger studies which explored the underlying aeti- studies.
ology and those who were more at risk of developing this. This is a The objective of this study is to analyse central coherence with
rare outcome and those with a history of anxiety and/or depression the The Rey-Osterrieth complex figure test (ROCF) in an eating
appear to be at increased risk of developing these disorders. disorder-sample.
Methods.– A sample of patients was recruited in our ED unit. E-PV0214

They completed several ED-questionnaires and were evaluated by Gender differences in patients with
a Psychiatrist specialist in Neuropsychology. Sociodemographical,
hypertension and D type of
clinical, psychopathological and neuropsychological variables were
collected. Data were analysed using SPSS 19.0.
personality according to presence of
Results.– A total of 81 patients were analyzed. All of them were risk factors
females with average age of 29.1 years (standard deviation, SD, G. Nikolic1* , O. Zikic1 , I. Tasic2 , N. Stojanovic3
1 University of Nis. School of Medicine, Department of Psychiatry, Nis,
9.8). IMC was on average 21.8 (SD 6.9). The distribution of diag-
noses was: 58% anorexia nervosa (AN), 39% bulimia nervosa (BN), Serbia; 2 Institute for Therapy and Rehabilitation Niska Banja. Serbia,
10% binge eating disorder (BED) and 18% other eating disorders. Cardiology, Nis, Serbia; 3 University of Nis, Physiology, Nis, Serbia
To measure the accuracy of figure, the quantitative index of the
copy of ROCF was 34.5 on average (SD 2.3) and of the recall trial
Background and aims.– Type D (distress) of personality is possible
was 19.2 (SD 6.1). The order of construction index was 2.2 (SD 0.6),
psychological risk factor for arterial hypertension.
style index 1.5 (SD 0.3) and coherence index 1.4 (SD 0.3).
Our aim was to determine the prevalence of type D personality
Conclusions.– In comparison with Spanish samples, quantitative
and gender differences in according to clustering psychological and
index of accuracy was above the 80th percentile for the copy and
biological risk factors, in our patients with arterial hypertension.
bellow the 40th one for the recall. No significant differences were
Methods.– Eighty-five patients with hypertension were included for
found between different ED in order or style index.
assessment of psychological and biological risk factors. Psycholog-
ical variables were Type D personality, anxiety, depression, overall
interest statement.
distress, and four dimensions of aggression. Biological parameters,
taken from medical database were: systolic/diastolic blood pres-
E-PV0213 sure, total cholesterol level, high density lipoproteins (HDL), low
density lipoproteins (LDL), triglyceride, blood sugar, Body Mass
The role psychotherapy in somatic Index (BMI), presence of Diabetes Mellitus (DM), and Metabolic
medicine syndrome.
B. Mykhaylov* , B. Fedak, V. Zabashta, O. Kudinova, T. Alieva Results.– More than half of the sample had Type D characteristics
Kharkiv Medical Academy of Postgraduate Education, Psychotherapy, and two third of them were female. Women with hypertension
Kharkiv, Ukraine and Type D of personality are more anxious and distressed, result-
ing in higher hyperlipidemia, obesity, and prevalence of DM when
compared to men.
Background and aims.– Over the last years there is a worldwide
Conclusions.– Women with hypertension and Type D of personality
steady growth of somatic diseases, in aetiopathogenesis of which a
are more prone to clustering risk factors then men and they are in
psychogenic factor plays a significant role. The same trend is repre-
possible greater risk for future unfavorable cardiac outcome.
sentative to Ukraine. Provided that in the clinical pattern of somatic
diseases are observed states posing a vital threat, such as Coro-
interest statement.
nary Heart Disease (CHD), Myocardial infarction (MI), Transient
Ischaemic Attacks (TIA), Celebral Stroke (CS) patients. The main goal
of our research were observed the psychosomatic relationships in E-PV0215
theese patients and established the psychotherapy oriented sup-
port system. Thas the 480 patients, were investigated 165 CHD, 90 When the sensation of shortness of
TIA, 105 CS, 110 MI. breath is more than a symptom of
Methods.– A formation of inadequate internal disease pattern, fear anxiety: pulmonary toxicity induced
of oneselves future promote generation and progression of mal- by maprotiline
adaptive psychological responses that are unfavourable for disease M. Oscoz Irurozqui1* , O. Alcoverro-Fortuny2 , Y. Galea-Colón3 , A.
prognosis and decrease a level of patients’ social function and life Mola Ausiró3 , L. Biosca-López3 , F. Viñas-Usán1
quality the all groups patients. 1 Benito Menni CASM, Consultation-Liaison Psychiatry, Granollers,
Results.– In most cases, an efficiency of treatment products depends Spain; 2 Benito Menni CASM, Acute Psychiatric Inpatient
on both adequacy of therapeutic methods choice and numerous Hospitalization, Granollers, Spain; 3 Hospital General de Granollers,
psychological factors. A formation of motivation, greater patient’s Pneumology, Granollers, Spain
involvement in treatment process is the philosophy of our psy- * Corresponding author.
chotherapy system, multimodal based. All patients were separated
on randomized intervened and control groups. The more high effi- Background and aims.– Maprotiline is a tetracyclic noradrenergic
cacy were observed in intervened groups (p < 0,05). antidepressant.
Conclusions.– It also requires an introduction of new organizational Drugs are a frequent cause of iatrogenesis and cause morbidity and
forms of medical and psychological and psychotherapeutic activ- mortality in up to 5% of hospitalized patients.
ity’s implementation on all levels of health care system. Provided We report a case of lung disease possibly due to maprotiline.
of importance is a development of new programs for medical and Methods.– A 59-year-old woman on antidepressant treatment with
psychological follow-up of such patients on different treatment maprotiline consults for dyspnea of 5 days of evolution; severe res-
stages. piratory insufficiency is confirmed and a ground-glass pattern and
Disclosure of interest.– The authors have not supplied a conflict of bilateral alveolar condensations are found in the chest X-ray, that
interest statement. were also visible on a radiograph a month ago. After discarding
pulmonary thromboembolism, heart failure and infectious pro-
cess, and given the suspicion of diffuse interstitial lung disease
(DILD) due to maprotiline, the drug, introduced 3 months ear-
lier, is removed and systemic corticosteroids are initiated. Clinical
and analytical screening is performed, and DILD associated with
connective tissue disease and inhalation of organic and inorganic
powders is discarded. Pulmonary functionalism reveals a parenchy-
mal restrictive disorder and stress desaturation.
Results.– A week later the patient is discharged. After one month, Spain; 3 Fundación Instituto San José, Investigation, Madrid, Spain; 4
the patient is asymptomatic, and functional improvement is Fundación Instituto San José, Nurse, Madrid, Spain; 5 Fundación
observed. Instituto San José, Geriatrician, Madrid, Spain
Conclusions.– Clinical presentation, radiological alterations, resolu- * Corresponding author.
tion of the picture with the drug withdrawal and exclusion of other
causes, support that maprotiline may be the cause of it; however, Background and aims.– Psychiatric comorbidity among patients
only a few similar cases are reported in the literature. hospitalized in general medicine units is high, with prevalence
Exact mechanism of injury induced by maprotiline is unknown and rates ranging from 15% to 50%. Even though the prevalence fig-
withdrawal is usually enough for resolution. ures are high, it is estimated that approximately 50% of cases has
Disclosure of interest.– The authors have not supplied a conflict of not an adequate diagnosis, which, consequently, causes a delay in
interest statement. the intervention and adequate treatment.
The organic cerebral syndromes (acute confusional syndrome and
dementias) and the anxious-depressive symptoms represent the
E-PV0216 most common cause of psychiatric intervention in the general hos-
Self-perception, depression and pital population.
It has long been known that psychiatric comorbidity contributes to
anxiety in end-stage renal disease
prolonged hospital stays, re-admissions and increased costs. That is
patients why, over the last few years, strategies have been developed for the
A. Papanastasiou1* , D. Vlachakos3 , P. Ferentinos2 , K. Tournikioti2 , early detection of symptoms and early therapeutic intervention.
A. Douzenis2 , I. Michopoulos2 Aims.– To describe the prevalence and type of associated psychiatric
1 Attikon University Hospital, 2nd Department of Psychiatry, Athens,
pathology presented by patients hospitalized in neurorehabilita-
Greece; 2 Medical School- National and Kapodistrian University of tion unit of Fundación Instituto San José.
Athens- Attikon University Hospital, 2nd Department of Psychiatry, Methods.– An observational, correlational, retrospective and cross-
Athens, Greece; 3 National and Kapodistrian University of Athens- sectional study will be conducted on patients hospitalized in the
Attikon University Hospital, Nephrology- Renal Unit Department, neurorehabilitation units of the Fundación Instituto San José in the
Athens, Greece period between September 1, 2017 and September 1, 2018.
Results.– Of the 180 patients, 109 (61%) had psychiatric disorders.
The most frequent disorders were depression (58.3%) and cerebral
Background and aims.– Depression and Anxiety are important clin-
organic disorder (26.2%).
ical issues for the quality of life and outcome of end-stage renal
Conclusions.– We conclude that one-third of the patients in neuror-
disease (ESRD) patients. Self-perception has been shown to be
rehabilitation units, had co-morbid psychiatric diagnoses. The most
linked to life expectancy and adaptability in many chronic diseases.
frequently disorders were depression and cerebral organic disor-
Objective.– To investigate the role of various aspects of self-
der. We recommend training general practitioners in the detection
perception with respect to depression and anxiety rates.
of psychiatric pathology to get better evolution of these patients
Methods.– Thirty-two ESRD patients undergoing hemodialysis and
either during a long term stay at general medical institutions.
33 controls were recruited for the study. The Hospital Anxiety and
Depression Scale (HADS) and the Self-Perception Profile for Adults
interest statement.
were used to assess anxiety, depression and self-perception respec-
tively.
Results.– No differences were found between patients and con-
E-PV0218
trols in anxiety and depression. Regarding self-perception, patients
scored worse than controls in athletic competence (p = 0,043), espe- Combined treatment of non-psychotic
cially male patients and those living in rural areas. Anxiety and mental disorders in patients with
depression levels were negatively correlated with self-assessment hyperthyroidism
in sociability (p = 0.016) and interpersonal relationships (p = .020) O. Pityk1* , I. Kuzhda2 , N. Karbovskyi1 , L. Tkachuk1
only in patients. Female patients rated themselves lower than their 1 Ivano-Frankivsk National Medical University, Psychiatry-
male counterparts in terms of sociability (p = 0.026) and intelli- Narcology and Medical Psychology, Ivano-Frankivsk, Ukraine; 2
gence (p = 0.016). Age was negatively correlated with self-image Ivano-Frankivsk Regional Children Hospital, Ophtalmological
for sense of humor (p = 0.022) and intelligence (p = 0.032), whereas Department, Ivano-Frankivsk, Ukraine
years of education were positively correlated with sense of humor * Corresponding author.
(p = 0.030) in the ESRD group.

Conclusions.– Self-image of athletic competence is compromised Background and aims.– The challenges for psychiatry in the 21st
and self-perception of sociability and interpersonal relationships century includes the promotion of mental health and prevention
correlates with significant clinical aspects in ESRD. Patients should mental disorders. It can be done due to integration between somatic
be encouraged to take regular exercise and be more supported to medicine and psychiatry mere. Mental disorder is a serious medi-
engage in social activities. cal and social problem, significantly affecting the quality of life of
Disclosure of interest.– The authors have not supplied a conflict of patients with somatic profile. The valid assessment of the health
interest statement. and the effectiveness of treatment is quality of life, defined by
WHO as “individuals perception of their position in life, including
physical, mental and social well-being, independence and quality
E-PV0217 of environment context of culture and value systems among whom
Psychopathological characteristics of they live, and according to their own objectives, expectations, stan-
dards and concerns”. The aim was to investigate the influence of
patients attended in
combined treatment which included psychotropic and psychother-
neurorehabilitation units apeutic methods. 125 patients were examined. Non-psychotic
M. Perez Fominaya1,2* , A. Lendínez Mesa3 , H. González López4 , P. mental disorders with different syndromologic structure were
Rodríguez San Juan5 , L. Donis5 , M. Casero Alcaraz4 , E. García found in 95 patients (main group), among which anxious-asthenic,
García4 anxious-depressive and asthenic psychopathological patterns were
1 Fundación Instituto San José, Psychiatry, Madrid, Spain; 2 Hospital
dominant. Significant difference was found in quality of life in
General Universitario Fundación Jiménez Díaz, Psychiatry, Madrid, patients of main and comparison groups.
Methods.– Quality of life was assessed using a questionnaire devel- Background and aims.– The aim of this study is twofold. First; to
oped Mezzich, Cohen, Ruiperez, Liu & Yoon (1999). critically review literature of body dysmorphic disorder (BDD). Sec-
Results.– Thus, mental disorders in hyperthyroidism require appro- ond; to examine three cases of body dysmorphic disorder; a male
priate correction that must take into account both biological and patient with a perceived defect of his face, a female patient with a
socio -psychological basis of specified disease and psychopatho- perceived defect in her right side of her body, and, a male patient
logical patterns which strongly affect the quality of life of such who presented with a perceived defect of his chest as well as face.
people. In addition, we will explore prevalence, clinical features, comor-
Conclusions.– The average in the overall perception of life (sense of bidities, and, association with suicidal ideations and attempts.
satisfaction and happiness in general) in the main group was 5.19 Methods.– Case study and literature search of the term “Body
in the control group - 6.50. dysmorphic disorder” using PubMed, selected relevant articles
Disclosure of interest.– The authors have not supplied a conflict of published in last 5 years in peer-reviewed journals.
interest statement. Results.– The review of the literature has shown that body dysmor-
phic disorder has a high level of comorbidity with other psychiatric
disorders, such as anxiety disorder and depression. Patients with
E-PV0219 BDD commonly have varied presentations and have high rate of
Depression as a major issue in chronic psychiatric admissions, in addition to high rate of suicidal ideations
heart failure and attempts. Recent evidence suggested that selective serotonin
O. Pityk1* , A. Sikora1 , S. Fedorov2 , N. Karbovskyi1 inhibitors and cognitive-behavioral therapy are often effective
1 Ivano-Frankivsk National Medical University, Psychiatry- Narcology treatment for BDD. All the three cases had comorbid depressive
and Medical Psychology, Ivano-Frankivsk, Ukraine; 2 Ivano-Frankivsk disorders, had suicidal ideations and had varied fixed belief with
National Medical University, Department of Therapy and Family regard to their perceived physical defect.
Medicine of Postgraduate Faculty, Ivano-Frankivsk, Ukraine Conclusions.– Individuals with BDD usually consult dermatolo-
* Corresponding author. gists and cosmetic surgeons rather than psychiatrists. They often
have variable presentations, and frequently referred to psychoso-
Background and aims.– Depression is a major issue in chronic heart matic medicine. Collaboration between different specialties would
failure (CHF) and its prevalence is about 20–40%, which is 4–5% optimize treatment outcome. Psychiatrist need to be diligent in
higher than in the normal population. The prevalence of depres- evaluating patients with BDD for other comorbid psychiatric con-
sion increases with New York Heart Association (NYHA) functional ditions and conduct a thorough suicide risk assessment.
class, with the biggest difference seen between NYHA classes II and Disclosure of interest.– The authors have not supplied a conflict of
III. The purpose of study was evaluation of correlations between interest statement.
depression and main hemodynamic and lipids’ metabolism param-
eters in patients with chronic heart failure. 80 patients with CHF
II-III NYHA classes caused by chronic coronary artery diseases (CAD) E-PV0221
were observed. All patients were divided into two groups: 1–20 Are psychogenic non epileptic
persons without signs of depression and 2–60 persons with depres- seizures being erroneously treated as
sion.
epilepsy?: a review about the
Methods.– Diagnosis of CHF was confirmed based on ESC guidelines
(2016). Depression was diagnosed by some questionnaires (Zung implications of the problem
Self-Rating Depression Scale, Beck Depression Inventory, Hamil- V. Romero Pardo1* , L. Mellado Cuerno1 , N. Fernandez Gomez1 , J.M.
ton’s Depression Scale). Pastor Haro1 , I.I. Louzao Rojas1 , R. Gallego Estebanez1 , J. Curto
Results.– Using Hamilton’s Depression Scale, it was established that Ramos1 , B. Rodriguez Vega1 , M.J. Aguilar-Amat Prior2 , P. Alonso
mild depressive disorders are mostly observed in patients with CHF Singer2
1 Hospital La Paz, Psychiatry, Madrid, Spain; 2 Hospital La Paz,
- 71.6% of patients. However, the average expression of depression
was observed in 23.4% of patients studied, severe one – in 3.3%, and Neurology, Madrid, Spain
extreme hard depression - in 1.7% of cases. It was reported about
the reciprocal medium strength relationship between the severity
Background and aims.– Our objective is to review the evidence about
of depression and the level of blood pressure: both systolic (SBP):
the main therapeutic interventions in non-psychogenic non epilep-
r = −0.30 and diastolic (DBP): r = −0.35.
tic seizures (PNES) and examine the consequences of treating it
Conclusions.– Therefore, patients with chronic heart failure and
erroneously as epilepsy.
depression have more strong central hemodynamic and lipid
Methods.– For this aim, we have reviewed the therapeutic choices
metabolism disorders versus without depression.
–pharmacologic and notpharmacologic– in patients with PNES and
the information about prevalence, cost and security of treating the
interest statement.
patients as epileptics.
Results.– High doses of antiepileptic drugs (AED) are some-
times used among patients diagnosed withPNES. Those kind of
E-PV0220
errors in treatment assignation are associated with more eco-
Body dysmorphic disorder: a nomic cost, pharmacologic iatrogenia and worse prognosis. A
literature review and case study well assigned treatment focused on psychoeducation –Cognitive
H. Raai1* , P. Manocha2 , A. Martin2 , L. Gonzalez3 , A. Khadivi4 Behaviour Teraphy (CBT), Interpersonal Theraphy (IPT)– has evi-
1 Montefiore Medical Center- Albert Einstein College of Medicine, denced effectiveness decreasing the number of crisis. Diagnosis
Department of Psychiatry and Behavioral Sciences, New York, USA; 2 acceptation predicts a better quality of life.
BronxCare Health System, Department of Psychiatry and Behavioral Conclusions.– Despite the availability of accurate methods to diag-
Sciences, New York, USA; 3 James J. Peters VA Medical Center, nose PNES, there are still many patients treated as epileptics. The
Psychiatry, New York, USA; 4 BronxCare Health System- and Albert acceptation and understanding about PNES diagnosis are essential
Einstein College of Medicine, Department of Psychiatry and for a correct treatment assignation that implicates different conse-
Behavioral Sciences, New York, USA quences. Therapies that focus on disease explanation have shown to
be effective. It is necessary to learn more about the PNES diagnosis-
communicating process in order to improve management.
Disclosure of interest.– The authors have not supplied a conflict of Results.– Twenty subjects were enrolled, 10 women and 10 men,
interest statement. 46.0 ± 11.6 years old, MMT duration of 6.6 ± 6.7, Bowel function
index (BFI) of 74.4 ± 20.8 and number of bowel movements (BM)
of 2.2 ± 1.2 at baseline. Subjects were randomized into two groups:
E-PV0222 one received naloxone treatment for 1 week followed by 1 week
HCV among patients with chronic of placebo and another received treatments in reverse order. There
mental disorders: the relevance of were no statistically significant differences between the two groups
at baseline. As a result of the treatment the BFI has decreased in
dual-diagnosis
both groups and both cohorts of patients reported increased num-
C. Roncero1,2,3* , Á. Martín-Sánchez1 , A.I. Alvarez1 , M.P. Andrés1 , B.
ber of bowel movements (5.3 ± 2.9 and 5.0 ± 3.0 after weeks 1 and
Vicente1 , C. Gamonal-Limcaoco1 , R. de la Mata1 , M.L. Aguilar1,2,3 ,
2, respectively, see Fig. 1). There was no significant association
F. Sanchez-Casado1 , J.L. Villegas1 , I. Valriberas1 , R. Alarcon1 , L.
between BFI and treatment sequence.
García-Ullán1,2,3
1 University of Salamanca Health Care Complex Salamanca,
Psychiatry, Salamanca, Spain; 2 University of Salamanca, Psychiatry,

Salamanca, Spain; 3 University of Salamanca, Institute of
Biomedicine of Salamanca, Salamanca, Spain
Background and aims.– Data on HCV prevalence among inpatients

with chronic mental disorders are scare. Even Dual Disorders
patients have not been well studied.
Methods.– 311 patients were admitted to a mid-long term psy-
chiatric inpatient unit from 2007 to 2018 (45.66% man, 43.32
mean age). Patients were referred from short psychiatric unit
because there has been hospitalized more than one o because
they need a mid term and intensive treatment. The main diagnosis
were 52.73% Schizophrenic or psychotic disorders, 13.83% bipolar,
18.65% depressive, OCD 3.22% and 11.57% others disorders.
Results.– 36.33% were dual diagnosis patients suffering an addi-
tion (excluding tobacco) and other mental disorders. 63.72% have
alcohol dependence, 25.66% cocaine dependence, 37.17% cannabis
Figure 1. Changes in the number of bowel movements per week.
dependence, 7.96% heroine dependence and 21.23% other drugs
such as caffeine and benzodiazepines. The prevalence of HCV C was Conclusions.– The use of oral naloxone for OIC had no effect on BFI,
3.22%: 7.08% in the DD -group and 0.64% in the non-DD group. but the objective improvement in bowel functioning was observed
Discussion.– The prevalence is higher than the general population. in both groups, which might be attributed to the placebo effect.
Especially the prevalence among DD patients is higher than the Disclosure of interest.– The authors have not supplied a conflict of
non-DD patients. interest statement.
Conclusions.– Although we study a sample mainly of non-
intravenous drug users the prevalence of CHV is higher that the
prevalence on general population, especially among the dual diag- E-PV0224
nosis patients. Patients suffering mental disorders different than Differences in psychometric profile
drug-dependence should be the next step in HCV the elimination
between malingerers and factitious
process.
Disclosure of interest.– The authors have not supplied a conflict of disorders
interest statement. A. Serrano García1* , I. González Rodríguez2 , P. García Vázquez2 , S.
Núñez Sevillano2 , M.L. Suárez Huerta3 , J. Valdés Valdazo2 , M.Á.
Heredero Sanz2
1 Complejo Asistencial Universitario de León. Universidad de León,
E-PV0223
Psychiatry, León, Spain; 2 Complejo Asistencial Universitario de León,
Reversing opioid-induced
Psychiatry, León, Spain; 3 Hospital Universitario de Cabueñes,
constipation in methadone users with Orthopedics, Gijón, Spain
oral naloxone: clinically meaningful * Corresponding author.
placebo effect?
A. Samokhvalov1* , J. Rehm2 Background and aims.– The main difference between Malinger-
1 University of Toronto, Department of Psychiatry, Toronto, Canada; 2 ing (M) and Factitious Disorders (FD) is that the first one is not
Centre for Addiction and Mental Health, Institute for Mental Health considered a mental disorder but a fraud behaviour. FD are a psy-
Policy Research, Toronto, Canada chopathological disorder in which the patient freight his symptoms
* Corresponding author. in order to be treated as an ill person, not in order to achieve an
economic or social benefit.
Background and aims.– Opioid-induced constipation (OIC) is a Objectives.– Explore the differences in the psychometric profile
severe and persistent side effect of methadone maintenance ther- between patients with FD and M.
apy. The effectiveness of conventional laxatives is questionable, Methods.– After a multidisciplinary approach patients were classi-
whereas the use of oral naloxone might be a promising and physi- fied as M or FD. All of them completed a standard psychometric
ologically justified solution. protocol which included the following test: Structured Inventory
Aim.– To test the effectiveness of oral naloxone for treatment of of Malingered Symptoms (SIMS), Sensitization Central Inventory
OIC. (SCI), Familiar Functioning Inventory (FF-SIL), Hospital Anxiety and
Methods.– Triple-blind randomized placebo-controlled clinical trial Depression Scale (HADS) and Sheehan Disability Inventory (SDI).
(n = 20). Crossover design. Mixed effects. Also sociodemographic data were collected. Statistical analysis was
performed in order to find psychometric differences between the Background and aims.– Psychodermatology or psychocutaneous
groups. medicine describes an interaction between dermatology and psy-
Results.– The sample after the evaluation of 287 patients was of chiatry.
39 M and 45 F. Differences were found in sex (p = 0.019), work Our study aimed to identify the OC symptoms and it’s severity
status (p < 0.001) and work coalification (p = 0.047). No differences among patients with different dermatological diseases. Also, to cor-
were found in academic status (p = 0.347) neither in marital sta- relate the OC symptoms with the quality of the life in this group of
tus (p = 0.173). Psychometry showed differences in Total SIMS patients Among our population.
(p = 0.008), Total SCI (P = 0.005), Total FF-SIL (p = 0.001). No differ- Methods.– The study was conducted in the dermatology cosmetic
ences were found in Total HADS (p = 0.842). outpatient clinic of Ain Shams university Hospital, to assess the OC
Conclusions.– FD show a different psychometric profile than M. They symptoms among patients seeking dermatological help. They were
score significantly higher for simulation test, for somatization test recruited every Saturday clinic in the period from August 2015 till
and show a worse familiar functioning than M. February 2016. Therefore 101 patients were recruited, above the
Disclosure of interest.– The authors have not supplied a conflict of age of 18 and below the age of 50 with no gender preference using
interest statement. GHQ for mental illness screening, MINI for the diagnosis of OCD,
YBOCS for the symptoms and severity of the OCD symptoms and
quality of life index to assess the quality of life of the patients.
E-PV0225 Results.– Using the Mini International Neuropsychiatric Interview
Psychiatric comorbidity in epilepsy. A for diagnosis of different psychiatric disorders in the sample with
caso report positive General health questionnaire the highest for Generalized
B. Serván1* , J. Ibañez2 , A. Carabias2 , B. Rodado2 Anxiety Disorder found in 24.8% of the population then OCD in
1 Hospital Clínico San Carlos, Psychiatry, Madrid, Spain; 2 Hospital 18.8% then past depression episode in 7.9% with suicidal risk in
Clinico San Carlos, Psychiatry, Madrid, Spain 2% whereas current depression found in 3%.
* Corresponding author. Conclusions.–
• Have different psychiatric comorbidities, the commonest is gen-
Background and aims.– Epilepsy was described as a chronic brain eralized anxiety disorder GAD, obsessive compulsive disorder
disorder characterized by recurrent seizures. However, throughout OCD then depression.
the twentieth century, several epidemiological studies emphasized • Among 101 dermatological diseases OCD was found in18.8%.
the presence of associated psychiatric symptoms, considering it as • The most common obsessions were contamination 57.9% The
a disease with a greater symptomatic spectrum than that classi- most common compulsions were cleaning 47.4% The OC symp-
cally described. On many occasions, a combined Psychiatry and toms in the OC group mainly mild in severity.
Neurology approach becomes necessary. Disclosure of interest.– The authors have not supplied a conflict of
Methods.– It is presented a case of a 53-year-old female patient, interest statement.
diagnosed with epilepsy since childhood, who is admitted to
Internal Medicine and assessed by Liaison Psychiatry for a
subacute-onset clinical presentation of temporo-spatial disorien- E-PV0227
tation, hypoproxesia, occupational delirium, anxiety, emotional Levetiracetam-induced psychosis, a
lability, suspicion, olfactory and cenestopathic hallucinosis and review of literature
visual illusions, upon which persecutory and reference delusions A. Stoppa1* , G. Anmella2
are elaborated. She has a history of depressive episodes and self- 1 Hospital de Terrassa- Consorci Sanitari de Terrassa, Department of
injurious behaviour. Psychiatry, Terrassa, Spain; 2 Hospital Clinic i Provincial, Department
Results.– Further evaluations: Blood test: leukocytosis with left of Psychiatry and Psychology- Institut Clínic de Neurociències,
deviation; PCR 32. Neurological assessment: suggestive of acute Barcelona, Spain
confusional state. Chest X-Ray: flattening of both diaphragms with * Corresponding author.
retrosternal air in relation to chronic bronchopathy. Brain and chest
CT scan without alterations. Background and aims.– Levetiracetam (LEV) is an antiepileptic drug
Conclusions.– The described symptomatology is compatible with approved for less than 20 years but with increasing prescription
a baseline epileptic disorder, decompensated to some extent by due to good tolerability. There are very few case reports of psychosis
erratic adherence to antiepileptic medication and recent respira- with LEV. Our purpose is to identify all case reports about psychosis
tory infection in the context of severe emphysematous COPD. In related to LEV.
this case, the treatment and resolution of the organic clinical pic- Methods.– From a bibliographical research using MEDLINE
ture and the introduction of antipsychotic treatment resulted in a (Pubmed) and key words “Levetiracetam” and “psychosis”, we
complete remission of the neuropsychiatric clinic. identified all case reports of LEV-induced psychosis.
Disclosure of interest.– The authors have not supplied a conflict of Results.– 56 articles were identified, with a total of 10 reported
interest statement. probable cases of psychosis induced by LEV, in which total remis-
sion of psychosis was reached when LEV was discontinued. LEV
psychiatric most common side effects are change in mood as
E-PV0226 depression (7,3%), irritability (12,5%) and anxiety (2,5%).
Obsessive compulsive spectrum and Conclusions.– LEV psychosis is very rarely reported (<1%). Neverthe-
quality of life among patients with less, it is not to be underestimated due to increasing LEV presence.
Since Epilepsy is itself related to psychosis, it is quite difficult to
cosmetic dermatological disease
distinguish whether psychosis after seizures is due to drug side
M. Shehata1* , M. Fekry Shehata2 , S. Elghonemy Shehata3 , A. Adel
effects or consequence of epilepsy itself. Several factors for differ-
Shehata4
1 Abbessya Mental Health, Psychiatry, Cairo, Egypt; 2 Ain Shams ential diagnosis can be considered, such as time between epileptic
crisis and psychosis and type of antiepileptic drug. Antiepileptic
University, Pschiatry, Cairo, Egypt; 3 Ain Shams University,
dosing and psychosis characteristics have not been identified to
Psychaitry, Cairo, Egypt; 4 Ain Shams University, Psychiatry, Cairo,
play a role in LEV induced diagnosis. Visual hallucinations, how-
Egypt
* Corresponding author. ever, may be considered as key symptom in LEV psychosis (present
in 3/10 case reports). No studies have shown individual charac-
teristics that make individuals prone to LEV adverse effects. More Although is one of the most diagnosed conditions by Psychiatry Liai-
studies are needed in this line. son at inpatient services (around 13%), AD remains poorly studied.
Disclosure of interest.– The authors have not supplied a conflict of To review the scientific literature regarding AD, to analise our data
interest statement. considering the first trimester of 2018 about psychiatric collabora-
tions at inpatient services, and to build guidelines for the evaluation
and treatment of depressive-anxiety symptoms for all inpatient
E-PV0228 services at Hospital Pedro Hispano (HPH).
Psychiatric presentation of a patient Methods.– Using the terms “Adjustment Disorder” and “Adjustment
with a falco-tentorial meningioma Disorder in Psychiatry Liaison” we searched Pubmed® , then analised
C. Tan, M.J. Yong and discussed the selected articles; on a second fase we analised
Khoo Teck Puat Hospital, Psychological Medicine, Singapore, and compared our data with the scientific literature; finally, we
Singapore built the guidelines and established them at HPH.
* Corresponding author. Results.– 13 out of 52 inpatients (25%) were diagnosed with AD,
from which 79% were secondary to a medical-cirurgical condition.
Background and aims.– Organic causes such as brain tumours can Only 31% have had a previous contact with a Psychiatric setting, and
sometimes present as psychiatric symptoms. This study describes 85% were medicated or had their pharmacological prescriptions
a case of falcotentorial meningioma presenting with psychiatric changed.
symptoms and discusses the challenges of identifying psychiatric Conclusions.– AD was the number one condition diagnosed at our
symptoms secondary to an intracranial mass and its subsequent study. While the criteria for AD are still controverse, and thus
management issues. difficulting its use amongst other medical specialities, its clinical
Methods.– Information was obtained from the patient’s medical importance is undeniable. More studies are needed to understand
records and direct interviews. AD real prevalence and undiagnosed morbidity. The guidelines we
Results.– Mdm.L, a 71-year-old lady first presented with memory built based on this study are now being applied.
loss and low mood. MRI brain revealed a right-sided mass sug- Disclosure of interest.– The authors have not supplied a conflict of
gestive of a falcotentorial meningioma, for which she opted for interest statement.
conservative management. Over the next four months, she devel-
oped hostility and aggression toward her family for which she was
commenced on valproate. She reported improvements in her mood E-PV0230
prior to defaulting her appointments. She presented again after six Adjustment disorder – a scientific
months following an attempt to jump from her apartment window. review
On arrival she appeared manic with overfamiliarity and flight of D. Teixeira1* , E. Palha2 , D. Faria3 , R. Quelhas3 , F. Ferreira3
ideas. She thereafter became agitated requiring restraints. A short 1 Centro Hospitalar Tondela-Viseu, Departamento Psiquiatria e Saúde
course of dexamethasone, together with haloperidol 0.5 to 1 mg Mental, Viseu, Portugal; 2 Unidade Local Saúde Alto Minho,
thrice daily, valproate 500 mg ON and clonazepam 0.25 mg ON as Departamento Psiquiatria e Saúde Mental, Viana do Castelo,
required was effective in reducing her agitation so that an MRI brain Portugal; 3 Unidade Local Saúde Matosinhos, Departamento Saúde
could be repeated. This showed interval enlargement of the tumour. Mental, Matosinhos, Portugal
Conclusions.– Her previously expressed wishes for conservative * Corresponding author.
management were honoured. Optimization of care involved man-
agement of her medical comorbidities, regulating psychotropics to Background and aims.– Adjustment Disorder (AD) is considered a
avoid excessive sedation and enhancing her environment to reduce situational disorder that occurs after a stressfull event and usually
confusion- such as positioning her utensils on the right of her tray resolves within a time period. Classified midway between the nor-
after she was found to have developed a left homonymous hemi- mal and the pathologic, it is a subtreshold diagnostic. Although is
anopia. She was eventually discharged to a nursing home. one of the most diagnosed conditions at Psychiatry Liaison consul-
Disclosure of interest.– The authors have not supplied a conflict of tations (around 12%), AD remains poorly studied partially because
interest statement. the criteria have changed dramatically over the years, in part due
to a lack of pathognomonic symptoms.
Our aim was to review the scientific literature regarding AD on a
E-PV0229 non systematic way.
Adjustment disorder – regarding the Methods.– Using the terms “Adjustment Disorder” and “Adjustment
retrospective analysis of requests for Disorder in Psychiatry Liaison” we searched Pubmed® and analised
the selected articles.
psychiatric collaboration at the
Results.– Suicidality occurs earlier in AD than in Major Depression
inpatient services and early intervention may prevent an evolution to another mental
D. Teixeira1* , E. Palha2 , D. Faria3 , R. Quelhas4 , F. Ferreira5 major disease. The diagnosis cannot simply rely on a group of symp-
1 Centro Hospitalar Tondela-Viseu, Departamento Psiquiatria e Saúde toms, but depends on the clinical judgement, the cultural context,
Mental, São Pedro do Sul, Portugal; 2 Unidade Local de Saúde do Alto the person’s vulnerability and coping mechanisms, and on the pre-
Minho, Departamento Psiquiatria, Viana do Castelo, Portugal; 3 sumption of which course the disease will take. While the criteria
Unidade Local de Saúde de Matosinhos, Departamento Saúde Mental, for AD remains controverse and thus difficulting its use amongst
Matosinhos, Portugal; 4 Unidade Local Saúde de Matosinhos, other medical specialities, its clinical importance is undeniable.
Departamento Saúde Mental, Matosinhos, Portugal; 5 Unidade local Adjustment Disorder New Module is a recent screening test and
saude matosinhos, Departamento Saúde Mental, Matosinhos, might help uniformize the criteria in the future.
Portugal Conclusions.– Although some argue that AD is a way of making nor-
mal experiencies pathologic, in our opinion AD is a mental disease
Background and aims.– Adjustment Disorder (AD) is considered a that needs to be diagnosed and treated just like the others. More
situational disorder that occurs after a stressfull event and usu- studies are needed to understand AD real prevalence and undiag-
ally resolves within a time period. Classified midway between the nosed morbidity.
normal and the pathologic, it is a subtreshold diagnostic and psychi- Disclosure of interest.– The authors have not supplied a conflict of
atric drugs are generally not recommended as the first treatment. interest statement.
E-PV0231 PCPs unanimously felt that the presence of psychiatrists into their
Assessment of temperament and working environment and their direct participation in their con-
personality traits of male patients sultations improved collaboration, helped decision-making and
treatment planning, especially in complex cases.
diagnosed with FMS Conclusions.– There is an opportunity for CL psychiatrists to develop
C. Tuz
primary care interfaces. Short CL intervention could be a model,
Erenköy FTR Hospital, Psychiatry, Istanbul, Turkey
which can reinforce the collaboration with PCPs and promote early
detection and efficient treatment of mental disorders in primary
Background and aims.– care.
Objective.– Physical and psychological symptoms of FMS are impor- Disclosure of interest.– The authors have not supplied a conflict of
tant in the clinical course of the disease. In this study, temperament interest statement.
and personality traits of male patients diagnosed with FMS were
investigated.
Methods.– 62 male patients who were examined at Erenköy FTR E-Poster Viewing - 7–9 April: Cultural Psychiatry
Hospital, FTR polyclinics in 2017 and diagnosed with FMS using
Modified 2010 ACR FMS Diagnostic Scale and 65 healthy male con-
trol groups were included in this study. Subjects were evaluated E-PV0233
with SCID-I, SCID-II, TPS, Beck Depression Scale, Fibromyalgia Effect Valued based psychiatry: time to
Questionnaire and HAM-D scales. Socio-demographic characteris-
think jointly
tics were detected. Whether there is difference between the groups
H. Al-Taiar
was analyzed by t test on parametric conditions and Mann-Whitney
MRCPsych SFHEA, Forensic Psychiatry at Oxford Health NHS
U test on nonparametric conditions.
Foundation Trust, Oxford, United Kingdom
Results.– FMS group and the control group were found to have * Corresponding author.
significant differences in avoidance of harm, shyness and anxious
approach to foreigners, loss of self, and spiritual acceptance scores Background and aims.– Values-based Practice (VBP) is a clinical
in terms of subscales of the TPS (p < 0.005). According to this, male skills-based approach to working with complex and conflicting val-
patients diagnosed with FMS were more pessimistic, self-confident, ues in healthcare. It is a twin framework to evidence-based practice.
diffident, introverted, weaker and get tired more quickly compared Aim.– to familarise audience with VBP in mental health settings. It
to the control group. will start by an ice breaking exercise asking the audience about
Conclusions.– what values are for them and clarifying VBP concept through a
Discussion.– As a result of the study, there were differences in the number of examples.
parameters of the TPS in FMS diagnosed male patients compared Methods.–
to the control group. In the study, all values are given in the tables. Issues of Focus.– What are values and why should psychiatrists take
Comments will be made using the tables. them seriously? Researchers suggest that considering the different
Disclosure of interest.– The authors have not supplied a conflict of values that mental healthcare professionals and patients bring to
interest statement. their experience in the clinical arena can help:
1 to make clinical care more patient-centred.
2 to address difficult conceptual issues such as diagnosis.
E-PV0232 3 discussion of difficult ethical dilemmas in clinical practice e.g.
Short psychiatric interventions in involuntary treatment.
primary care - a model of Results.– Dyadic approach: there is no relevant experience outside
consultation-liaison psychiatry the consulting space. The patient brings a problem, which the doc-
K. Tzartzas* , T.S. Goncalves Alvane, C. Derbel, R. Marion-Veyron tor considers thoughtfully. The therapeutic focus is on the problem
University of Lausanne, Department of Ambulatory Care and itself. Removing or ameliorating the problem is the doctor’s task
Community Medicine, Lausanne, Switzerland who takes action to do this and with that action the relationship
* Corresponding author. ends.
Systemic thinking: assumes that the patient exists within a number
Background and aims.– Mental and substance use disorders are the of social systems or groups and has different roles in each of them.
leading cause of non-fatal burden of disease. Different ways of Although ‘the problem’ has a clinical aspect, it also has meanings
working at the interface between primary care and psychiatrists for the patient that are outside the doctor’s experience.
are described, but psychiatry is yet to consider how to develop this Conclusions.– The most important reason for the increasing impor-
way of working. Consultation-liaison (CL) psychiatry could deliver tance of values in medicine has to do with the emergence of a
high-quality integrated mental health care, when correctly adapted model of patient-centred practice in which the values of individual
to specific local primary care settings. The aim of this study was to patients are central to evidence-based clinical decision-making.
demonstrate the feasibility and the effectiveness of CL for patients Disclosure of interest.– The authors have not supplied a conflict of
consulting a primary care physician (PCP). interest statement.
Methods.– An observational study was conducted in the Depart-
ment of Ambulatory Care and Community Medicine at the Univer-
E-PV0234
sity of Lausanne (Switzerland). The CL psychiatrist provided con-
sulting, tripartite sessions and brief psychiatric/psychotherapeutic Parents’ representations and
interventions. expectations from the child in
Results.– The first 100 inquires were collected and analyzed. In different historical conditions and
36 cases, consulting (without meeting the patient) was enough their influence on the emotional and
to manage the situation; 64 patients were seen by the psychia-
trist (at least one session). In 58/64 (91%) interventions a first joint
personal development of the children
N. Burlakova* , P. Davidovich
consultation was conducted (CL-PCP-patient) and in 51 (80%) a
Lomonosov Moscow State University- Faculty of Psychology,
brief psychiatric and psychotherapeutic intervention was carried
Department of Neuro- and Pathopsychology, Moscow, Russia
out. Only in one case a psychiatric hospitalization was necessary. * Corresponding author.
Background and aims.– The study explores a subjective image chronic illness significantly influences the organizational processes
attributed by parents to their child that was shaped under the influ- of clinical assessment.
ence of different historical conditions: in the period of the crisis of Disclosure of interest.– The authors have not supplied a conflict of
1992–2000 and the stabilization period of 2012–2015 in Russia. interest statement.
Methods.– The study focuses on two groups of families (group 1,
n = 24, children born in 1992–1993, group 2, n = 31, children born
in 2006–2009) at the time of the study they were 5,5–7 years old, E-PV0236
attended additional developmental activities. Management of obsessive compulsive
The research involved qualitative analysis of objective historical disorder in three muslim refugee
and socio-demographic data, results of interviews with parents,
patients in the German context: a case
long-term observations in children institutions.
Results.– The following areas of risk in intergenerational transmis- series
sion are identified: N. Elnahrawy1* , M. Elsheikh2
1 Mainz University Hospital, Department of Psychiatry and
1) discrepancy of ambitions and claims among parents in the 1st
group with the real level of development of the child; conflicting Psychotherapy, Mainz, Germany; 2 Al-Azhar University Hospital,
parental aspirations in the 2nd group; Department of Psychiatry and Psychotherapy, Cairo, Egypt
2) various risky accents in the same qualities encouraged by par-
ents of different generations: Background and aims.– Obsessive Compulsive Disorder (OCD) is
a. the encouragement of “independence” with a focus on the the fourth most common mental disorder. A delay in help-seeking
need to rely only on themselves in the 1st group, and individ- behaviour as well as the associated feelings of shame and guilt make
ualistic nonconformism in the 2nd group; OCD difficult to diagnose. In the arab muslim culture, contamina-
b. emphasis on “thrusting, leadership qualities” in the view of tion and religious obsessions have been found to be the commonest
parents, in the 1st group understood as activity, defensive kind of obsessive thoughts. The availability of culturally sensitive
aggression, in the 2nd group, as an explanation of difficulties mental health services for refugee populations in Germany is lim-
of targeting at the other. ited. Here we aim at (1) Explaining obstacles to diagnosing and
Conclusions.– Representations and expectations posed by a specific treating OCD among arab muslim patients in the German context
family, cohort and more broadly - an entire generation that deter- and (2) Suggesting a set of culturally relevant clinical questions that
mine the emotional-personal risks and adaptive potential of the lead to correct diagnosis of OCD in these patients.
child are shown. Methods.– A case series of three asylum seekers: two females (25
Disclosure of interest.– The authors have not supplied a conflict of Arab, 37 Kurdish) and one male (27 Arab) from middle-eastern
interest statement. background is presented. The difficulties to correctly diagnose OCD
in the primary health care system is explained. The course of treat-
ment is highlighted and a set of clinical questions that enable the
E-PV0235
diagnosis of OCD in Muslim patients is presented. Methods to over-
“Types of delusions in psychiatric come incompliance and treatment resistance are discussed.
population comparing with general Results.– In the presented case series, use of the proposed culturally
population” relevant set of clinical questions enabled the correct diagnosis of
E.M. Ciorabai OCD in muslim patients within a German context.
Universitatea Ovidius Constanta, Psychiatric Clinic, Constanta, Conclusions.– OCD in refugee muslim patients is difficult to diag-
Romania nose for many reasons. Culturally sensitive assessment is crucial
* Corresponding author. to avoid under- or misdiagnosis of OCD. Attention to key motives
regularly found in Arab muslims with OCD can enable correct diag-
Background and aims.– Abstract: Abnormal paranoid ideation is a nosis.
fixed, false belief, based on incorrect inferences about social real- Disclosure of interest.– The authors have not supplied a conflict of
ity, external to, or about oneself, starting with overvalued ideas interest statement.
contrasting with delusional ideas. The occurrence of these types
of paranoid ideas were assessed in patients hospitalized in Psychi-
atric Clinic and two control samples of students in first and sixth E-PV0237
year in Medical School, and a sample of patients with neurological The role of mass media in mental
conditions.
health stigmatization: a double-edged
Cultural formulation, cultural dynamics and treatment outcome
was assessed, False belief is viewed as a scientific puzzle to be Weapon
solved comparing with the view as a chronic illness. N. Ghazouani1* , S. Ellouze2 , Z. Boudeli1 , O. Moula2 , R. Ghachem2
1 Medical school of Tunis, psychiatry, tunis, Tunisia; 2 Razi university
Methods.– We carried out serial interviews with patients hospi-
talized in Psychiatric clinic in emergency room comparing with hospital, psychiatry, Manouba, Tunisia
interviews with students in medical school and with neurological
patients. We used items from “Green at al Paranoid Thought Scale” Background and aims.– Mental health stigma is the false association
Results.– The most common ideas include delusion of control, value of patients with mental illness, their families, friends and health
judgement, when the value judgment made is so extreme that it care providers with something shameful. The role of media as an
is not credible. Delusional misidentification syndromes associated anti-stigma tool has not been unanimously advocated.
with doubt, need to verify, to control occur commonly in the context The aim of this study was to expose both the negative and positive
of neurological conditions affecting the right hemisphere. the pres- effects of mass media on psychiatric stigma with a highlight on
ence of these types of delusions should determine a neurological changing the media’s approach to serve as an anti-stigma tool.
evaluation for potentially aethiologically treatable conditions. Methods.– A literature review using the subsequent databases:
Conclusions.– A continuum from dominant ideas, overvalued ideas, Pubmed, Sciencedirect, Embase and the keywords: mass media,
delusional ideas affect the clinical consequences of trust, particu- social media, mental illness, and stigmatization.
larly how and when the diagnosis is delvered. whether pathological Results.– The negative impact of social media consists in the inac-
belief is viewed as a scientific puzzle to be solved or is seen as a curate representations of mental illness in the mass media, the use
of stigmatizing language in relation to the mentally ill, the depic- Background and aims.– The aim of this study was to investigate the
tion of mental illnesses as unsurmountable, and the identification relationship between cultural intelligence and emotional creativity
of mental illness with violence and criminality in popular film and with learning English in students.
literature. Meanwhile, if used properly, media can serve as one of Methods.– The research method was correlational. The statistical
the most important anti-stigma tools through the embracing of an population of this study was high school schools that 150 students
anti-stigma discourse, the promotion of a new approach based on a were selected and responded to Ang et al’s cultural intelligence
less sensational media reporting and awareness examples of cam- questionnaire, Averill’s emotional creativity inventory and learning
paigns that focus directly on the stigma of mental illness with the English scores. The data were analyzed by using Pearson correlation
aim of changing public attitudes to mental illness on a broader level. formula.
Conclusions.– If used in a goal directed approach, mass media is Results.– The findings of this study showed that there is a posi-
a powerful tool to address the stigma surrounding mental health, tive and significant correlation between cultural intelligence and
raising the awareness about the mental health patients suffering emotional creativity with learning English.
and struggle and not pinpointing their difference as a source of Conclusions.– Based on the findings, cultural intelligence and emo-
violence and social unrest. tional creativity are very important and influential factors on
Disclosure of interest.– The authors have not supplied a conflict of learning English language, and also in intercultural relations with
interest statement. people from different languages and cultures.
E-PV0238 interest statement.
Transcultural medicine, cultural
knowledge in the clinical work E-PV0240
S. Golsabahi-Broclawski
Psychometric properties of the urdu
MITK, Psychiatry, Bielefeld, Germany
* Corresponding author. translation of the dissociative
experiences scale among a
Background and aims.– The interaction of care providers and non-clinical sample of Pakistani
patients or their relatives is culturally shaped by different norms,
university students
values and everyday-world ideas. For example, the understanding
C.A. Lewis1,2* , S. Musharraf3 , J.A. Malik4 , M.J. Dorahy5 , M.J. Lewis6
of health, illness and death, as well as the demands and expecta- 1 Bishop Grosseteste University, School of Social Sciences, Lincoln,
tions of care, can be intercultural. Cultural and linguistic barriers
United Kingdom; 2 University of Warwick, Centre for Education
as well as cultural stereotypes can make a goal-oriented treatment
Studies, Coventry, United Kingdom; 3 The Women University, Applied
more difficult.
Psychology, Multan, Pakistan; 4 Quaid-i-Azam University-, National
Methods.– The Academy for Continuing Medical Education offers
Institute of Psychology, Islamabad, Pakistan; 5 University of
the curricular training “Transcultural Medicine - Cultural Com-
Canterbury, Psychology, Christchurch, New Zealand; 6 Glyndŵr
petences in Clinical Everyday Life in Cooperation with Medical
University, Psychology, Wrexham, United Kingdom
Transcultural Institute in Bielefeld. * Corresponding author.
Modules are:
1 Introduction to transcultural medicine Background and aims.– Dissociative disorders are common in
2 Culturespecific specificities of the diagnostics, taking into Pakistan, accounting for over 10% of admissions in psychiatric
account cultural-specific examination methods wards. Despite this, little attention has been given to the suitabil-
3 Medical Specialties in the Transcultural Context: GENERAL ity of established psychometric measures of dissociation in this
MEDICINE /SURGERY context. The Dissociative Experiences Scale (DES) is a widely used
4 FOCUS - NEUROLOGY / PSYCHIATRY 28-item self-report measure of dissociation that has been trans-
5 FOCUS - PSYCHOSOMATIC lated into a number of languages. The aim of the present study was
6 FOCUS - WOMEN’S CURE AND GE-BURTLEHILFE / CHILDREN AND to examine the psychometric properties of the recently translated
YOUTH MEDICINE Urdu version of the DES among a non-clinical sample of university
Results.– The Transcultural Medicine is part of the Study of German students in Pakistan.
physicians and it is settled as part of the medical training. Methods.– A convenience sample of 253 university students in
Conclusions.– Transcultural competence is increasingly important Pakistan completed a short survey comprising of the Urdu version
in everyday clinical practice. A stress factor because the usual tech- of the DES and the English version of the DES, along with the Urdu
niques and procedures of the service providers do not reach or even version of the Eysenck Personality Questionnaire (EPQ).
miss their goal and lead to misunderstandings and injuries on both Results.– The Urdu version of the DES demonstrated high internal
sides. This can lead to misunderstandings in the communication consistency (alpha = .91), cross-language validity (rs = .89 to .93),
and the psychosocial care of migrants, as well as to problems in satisfactory temporal stability over four weeks (r = .89), and good
diagnostics, therapy and care. We offer since 2015 the Transcultural convergent validity with the Urdu version of the EPQ’s Extraversion,
Training to improve the Treatment of Migrants. Neuroticism, Psychoticism, and Lie subscales. Exploratory factor
Disclosure of interest.– The authors have not supplied a conflict of analysis of the Urdu version of the DES suggested a single factor
interest statement. model was the best description of the data.
Conclusions.– These findings provide satisfactory evidence for the
reliability and validity of the Urdu version of the DES among a
E-PV0239 non-clinical sample of university students in Pakistan and it is rec-
Relationship between cultural ommend for further use among Urdu speakers.
intelligence and emotional creativity Disclosure of interest.– The authors have not supplied a conflict of
with learning english in students interest statement.
M.S. Hosseini1 , A. Homayouni2* , S. Shahriary2
1 Department of Psychology- Bandargaz Branch- Islamic Azad
University- Bandargaz- Iran, I, I, Iran; 2 Department of Psychology-
Bandargaz Branch- Islamic Azad University- Bandargaz- Iran, l, l, Iran
E-PV0241 Inventory Version 3.1 (OSI 3.1) and four additional items foe the
Exploratory factor analysis of the Addictive Features section.
Urdu translation of the Ottawa Methods.– The OSI 3.1 and four additional items for the Addictive
Features section were translated into Russian and back-translated
self-injury inventory version 3.1 into English by two experienced translators and one experienced
among a sample of Pakistan students psychologist familiar with health-related research. Subsequently,
C.A. Lewis1,2* , S. Davis3 , T. Sohail4 , A.O. Khawaja4 , J.A. Malik5 , S. a sample of 20 bilingual Russian students completed the English
Musharraf6 version of the OSI 3.1 and four additional items for the Addictive
1 Bishop Grosseteste University, School of Social Sciences, Lincoln,
Features section. Two weeks later, the respondents completed the
United Kingdom; 2 University of Warwick, Centre for Education Russian version. In contrast, this procedure was counter-balanced
Studies, Coventry, United Kingdom; 3 Glyndŵr University, by a further sample of 20 bilingual Russian students who completed
Psychology, Wrexham, United Kingdom; 4 Lahore College for Women the Russian version first, and then two weeks later the English
University, Applied Psychology, Lahore, Pakistan; 5 Quaid-i-Azam version.
University, National Institute of Psycholog, Islamabad, Pakistan; 6 Results.– No matters of concern with the translation process were
The Women University, Applied Psychology, Multan, Pakistan identified by the three translators. Moreover, in terms of cross-
language validity, a very strong positive association was found
between responses to the English version of the OSI 3.1 and the four
Background and aims.– The growing interest in self-harm (non-
additional items in the Addictive Features section with responses
suicidal self-injury) has been accompanied with the development
to the Russian version.
of a number of self-report measures of self-harm. One such mea-
Conclusions.– These findings provide preliminary evidence for the
sure of self-harm is the Ottawa Self-injury Inventory Version 3.1
cross-language validity of the Russian version of the OSI 3.1 and
(OSI 3.1), which measures both the functions and potential addic-
the four additional items in the Addictive Features section among a
tive features of self-harm, and has been translated into a number
non-clinical sample of bilingual university students in Russia. Sug-
of foreign languages. However, as yet, the Urdu translation has not
gestions for further research among Russian speakers are provided.
been subjected to any empirical analysis. The aim of the present
study was to examine the factor structure of the Urdu translation
interest statement.
of the OSI 3.1 and four additional items in the Addictive Features
section among a non-clinical sample of young female Urdu speakers
in Pakistan. E-PV0243
Methods.– Data was collected from a non-clinical sample of 200
female Pakistani university students who completed the Urdu ver-
The language of exclusion in mental
sion of the OSI 3.1 and four additional items in the Addictive health
Features section. Data was subsequently subjected to exploratory C. Sanahuja Muñoz* , M.I. Jimenez Martinez
factor analysis. Hospital Infanta Leonor, Mental health service, Madrid, Spain
Results.– Exploratory factor analysis revealed four functions factors
(internal emotion regulation, social influence, external emotion
Background and aims.– To describe the sociological and psychologi-
regulation, and sensation seeking) and one addictive features fac-
cal implications that are derived from the language used by people
tor. Each of the four functions factors was significantly positively
who live or develop in contexts of exclusion within contemporary
associated with each other. These findings are comparable to those
societies.
reported previously among other samples.
Methods.– Comprehensive bibliographic review using different
Conclusions.– These findings provide preliminary evidence for the
sociological, linguistic and psychological / medical databases.
factor structure of the Urdu version of the OSI 3.1 and four addi-
Results.– In the literature, there are references to the linguistic
tional items in the Addictive Features section among a non-clinical
and sociological analyses of the particular ways in which people
sample of university students in Pakistan and it is recommended for
in contexts of exclusion have to express themselves in modern
further use among Urdu speakers. Suggestions for further research
intercultural societies; however, there are no studies on this same
are provided.
subject aimed at daily clinical practice or focused on the different
symptomatic expressions.
interest statement.
Conclusions.– it is necessary to open a new channel of research
regarding the language of exclusion and its application in daily
E-PV0242 clinical practice.
Cross-language validity of the Russian interest statement.
translation of the Ottawa self-injury
inventory version 3.1 among a sample
of bilingual Russian students E-PV0244
C.A.Lewis1,2,3* ,
S. Davis4 ,
E. Filimonova5 ,Z. Safina5 ,S. What patients think about quality of
Galyautdinova3 , M. Khukhrin3 psychiatric care in different countries
1 Bishop Grosseteste University, School of Social Sciences, Lincoln,
A. Schröder1* , L.O. Lundqvist2
United Kingdom; 2 University of Warwick, Centre for Education 1 Norwegian University of Science and Technology NTNU- Gjövik,
Studies, Coventry, United Kingdom; 3 Bashkir State University, Department of Nursing- Faculty of Health- Care and Nursing-
Psychology, Ufa, Russia; 4 Glyndŵr University, Psychology, Wrexham, Norwegian University of Science and Technology NTNU- Gjövik.,
United Kingdom; 5 Bashkir State University, Translatology, Ufa, Gjövik, Norway; 2 University Health Care Research Center, Faculty of
Russia Medicine and Health- Örebro University, Örebro, Sweden
Background and aims.– As a first step toward establishing a coher- Background and aims.– The international project Quality in Psychi-
ent research programme examining the mental health correlates of atric Care (QPC) is a large research programme aiming at adapting
self-harm (non-suicidal self-injury) in Russia, the aim of the present the versions of the QPC instrument for patients and staff to different
study was to develop a Russian translation of the Ottawa Self-injury international settings.
The aim is to describe the quality of care among patients and staff E-PV0246
as measured by this instrument in different countries and to test Pharmacotherapeutic strategy in
the psychometric properties of the different language versions of individual treatment of patients with
QPC.
Methods.– The QPC has been developed on the basis of interviews
alcohol addiction from various ethnic
with patients where they were asked what they perceived as qual- groups
ity of care. In this project we used the instrument versions for A. Mandel, T. Shushpanova* , N. Bokhan, T. Novozheeva
patient and staff in Forensic in-patient care, In-patient care and Mental Health Research Institute, Tomsk National Research Medical
Out-patient care. Center, Addictive State Disorders, Tomsk, Russia
Results.– So far in this international project it shows that patients Background and aims.– Optimization of disturbed homeostasis dur-
and staff in different cultures and health care systems may have ing acute or chronic consumption of ethanol provided by a specific
different views on some aspects of quality of care, but most of all mechanism through of endogenous neurosteroid (NS) activity may
that they have many views in common, particularly the low ratings prove to be a useful pharmacotherapeutic strategy in individual
on participation. treatment of patients with alcohol addiction from various ethnic
Conclusions.– The psychometric test and validations of the instru- groups.
ment QPC in different language and country versions will assist Methods.– The study included 68 patients with alcoholism only men
countries to compare quality of care, quality improvement and and 23 healthy volunteers, standardized to the main group in age.
permits benchmarking. Patients were treated at the Department of Addictive States Men-
Disclosure of interest.– The authors have not supplied a conflict of tal Health Research Institute. The studies of the effect of therapy
interest statement. with Galodif (meta-chloro-benzhydryl urea) on the levels of NS
were performed by assigning Galodif 300 mg/day during 21 days
of treatment. Cortisol (Cs) and Progesteron (Pg) were determined
E-PV0245 with use kits for enzyme-linked immunosorbent assay (ELISA).
Subjective well-being of bilinguals Results.– Using therapy with Galodif in alcoholic patients induced
reduction of symptoms specific for alcohol withdrawal syndrome.
and monolinguals living in the
Galodif decreased level of Cs on 138% and increased level of Pg on
multilanguage regions of Russia: a 160%, making it means like in samples from healthy control group.
pilot study Alterations levels of NS in alcoholic patients suggest the abrup-
L. Shaigerova, Y. Zinchenko, R. Shilko* , A. Raevskiy tion regulation of NS as one of the mechanisms of development
Lomonosov Moscow State University, Psychology, Moscow, Russia of compulsive craving for alcohol. Comparative study of NS levels
of alcoholic patients showed significant decrease the level of Pg,
compared with healthy donors; investigations levels of Cs showed
Background and aims.– The rising scientific and practical interest to
significant increase of alcoholic patients, especially in patients from
the problem of bilingualism resulted in the studies of the influence
Tuvinian ethnic group.
of bilingualism on the cognitive processes (memory, attention, per-
Conclusions.– New approaches in psychopharmacotherapy of alco-
ception and thinking) and on the cultural identity formation. The
hol craving and prevention of relapses in alcoholic persons from
connection between bilingualism/monolingualism and the mental
different ethnic groups are associated with genetic anthropometric
health and subjective well-being has not been studied enough.
peculiarities.
The aim of the research is to study connection between bilingual-
ism/monolingualism and subjective well-being.
interest statement.
Methods.– Respondents (N = 120) from three multilanguage and
multicultural regions of Russia (Respublic of Crimea, Respublic of
Tatarstan, Respublic of Dagestan), which have their own official lan- E-PV0247
guages except Russian, took part in the pilot study. The respondents
Unconscious and persuasion: close
were divided into two parts: (1) - people who speak only Russian,
(2) - people who speak both Russian and other official languages in relationship in decision making
the regions of Russia, where the study was conducted. The respon- D.F. Vargas Chavez
dents answered the question, how often they feel happy, according Instituto Colombiano del Sistema Nervioso, Clinica Montserrat,
to the Likert scale from 1 to 5 (1 - always, 5 - never). Bogotá DC, Bogotá, Colombia
Results.– Independently of the ethnicity, age and region, monolin-
guals feel significantly less happy than bilinguals and multilinguals.
Background and aims.– Perform the tour for each of the areas that are
It is true even in the case when the absolute majority of population
involved in decision making and persuasion, from psychiatry and
in a certain region (for example, according to the 2014 population
its involvement in the economy, politics and advertising. Explaining
census, 84% in Respublic of Crimea) considers Russian as a mother
the motivation given by the winner of the Nobel Prize in Economics
tongue.
2017 - Richard Thaler, with his theory of decision making, later with
Conclusions.– Thus, the results have indicated a positive correlation
Sigmund Freud’s father and nephew, Mr. Edward Bernays, then the
between bilingualism/multilingualism and subjective well-being
neurobiological and neurophysiological explanation. The approach
in the regions where several languages are considered official.
to the collective unconscious and the archetypes of Carl Jung, and
The reported study was funded by RFBR according to the research
how these are connected later with the commercial archetypes.
project No. 17-29-09167.
Later, explain the use of persuasion in contemporary psychiatry,
as a technique in psychotherapy, implemented by the psychiatrist
interest statement.
Paul Dubois. The characterization of the characteristics in the neu-
ropolitica, given by: Character, Credibility, Dynamism, Charisma
and Leadership. Explain the three important terms in psychiatry:
political psychiatry, psychopolitics and biopolitics.
Methods.– Review of the literature about the historical journey from
psychiatry in decision-making and its important role in the differ-
ent areas such as politics, economy and publicity, as well as the
correlation with neurobiology and psychotherapy.
Results.– The approach of cultural psychiatry, can be studied from ple. This practice associated with stigma or as an effort to ensure the
different areas, which have had historical importance from the safety. However, neither type of explanation can relate this case to
political and economic. At the time of the study, findings are the treatment gap issue. This article critically reviews the current
found in brain and psychic functioning in decision-making and studies that have investigated the physical restraint characteris-
persuasion. Evidencing psychotherapeutic approach, economic and tics and scarce-resource in mental health services, particularly in
political strategies, based on the exhaustive study of this topic. the case of pasung. The analysis aims at developing recommenda-
Conclusions.– Psychopolitics, biopolitics, neuroeconomics and neu- tions for optimising community resources to minimise treatment
romarketing are areas of research and action on the psychological gap and reduce the rate of physical restraint.
aspects of human behavior, leading to decision-making in different Methods.– The review identified the report discrepancies from
sectors, influencing global dynamism. articles published between 2008 and 2018 with quantitative and
Disclosure of interest.– The authors have not supplied a conflict of qualitative studies in the field.
interest statement. Results.– Results demonstrate various motives and strategies in
low-resource settings to deal with physical restraint. The treatment
gap moderated by the lack of cost-effective services in local con-
E-PV0248 text, minimum treatment coverage and the absence of monitoring
Description of the content and after patients discharged from mental health hospitals.
characteristics of auditory Conclusions.– This study contributes towards understanding of
treatment gap within physical restraint for severely mentally
hallucinations: phenomenological
ill people. Using the existing analysis, stakeholder can create
aspects in Pakistani patients evidence-informed policy. Future studies and scope of intervention
S. Vargas* , F. Collazos should consider an iterative process of involving communities in
Hospital Vall d’Hebron, Psychiatry Unit, Barcelona, Spain capacity development to prevent pasung or other forms of physical
restraint.
Background and aims.– Hallucinations are a universal human expe- Disclosure of interest.– The authors have not supplied a conflict of
rience, present in all cultures, already described since Ancient interest statement.
Greece. In contrast to the pathological vision of Western society,
non-Western cultures often attribute them to spiritual phenom-
ena. Both aspects of the immediate environment and of the culture E-Poster Viewing - 7–9 April: Depression
itself can have a relevant impact, determining the characteristics
and content of delusions and hallucinations.
The present article aims to describe the content of auditory hallu-
cinations in Pakistani patients with psychosis. E-PV0250
Methods.– We describe the content of auditory hallucinations Depression in the elderly. A series of 9
through internationally validated instruments in three Pakistani patients
patients with chronic psychosis. N. Arbelo1* , G. Anmella1 , S. Gomes da Costa1 , C. Llach1 , L. Ilzarbe1 ,
Results.– The three patients reported auditory hallucinations in E. Arauz2 , A. Benabarre3
the form of animal noises (birds, barking dogs ...), in contrast to 1 Hospital Clinic de Barcelona, Department of Psychiatry and
the usual third-person auditory hallucinations of the first-rank Psychology, Barcelona, Spain; 2 National Institute of Mental Health,
symptoms described by Kurt Schneider, so common in Western Department of Psychiatry, Panama, Panama; 3 Bipolar Disorder
countries. Program- Hospital Clinic- University of Barcelona- IDIBAPS-
Conclusions.– To date, articles on hallucinations in different ethnic CIBERSAM, Department of Psychiatry and Psychology, Barcelona,
groups have focused mainly on the study of its prevalence and type. Spain
Regarding auditory hallucinations, they tend to be cited as “listen- * Corresponding author.
ing to voices”, according to Schneider description. Nevertheless, a

phenomenological description shows different contents, such as Background and aims.– Depression is one of the most frequent men-
animal sounds in this case, that may have a relevant symbolic tal disorders in adults aged over 60. In view of the rapid aging of the
weight in patient’s religious world, questioning the supposed uni- population, it is clear how depression in the elderly will be soon a
versality of Schneider’s first-rank criteria. Western-based therapies public health challenge.
may ignore the meaning of patients’ experiences in the treatment The objective of the study is to evaluate the social situation, comor-
of hallucinations in other cultures. bidity and clinical course of depression in older adults.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– It is a case series of the patients aged ≥65 admitted
interest statement. for depressive disorder in a psychiatric ward during a period of 3
months. Socio-demographic information, medical history and clin-
ical variables were studied.
E-PV0249 Results.– 9 patients were included (67% women) with a mean age
‘Pasung’ and other forms of physical of 78(±8,53). 100% were widow or single, and 89% lived alone. 67%
(n = 6) were diagnosed with major depressive disorder which first
restraint: a critical review of the episode had happened before age 65 in 67% (n = 4).
treatment gap for severe mental Hypertension (55%), dyslipidemia (37,5%) and hypothyroidism
illness in low-resource settings (37,5%) were usual comorbidities and a 78% had altered laboratory
A. Wijayanti markers of malnutrition. Complications like infections or delirium
University of Glasgow, Institute of Health and Wellbeing, Glasgow, were common (66,6%).
United Kingdom The mean duration of admission among these patients was larger
than the mean duration in the ward (28,6 vs 18 days). A 55% (n = 5)
stayed ≥3 weeks because of poor response to medication (100%),
Background and aims.– Physical restraint has been used widely in complications (40%) or lack of family support (40%).
institutions or by caregiver worldwide. The caregivers in some Conclusions.– Older adults hospitalized for depression usually have
countries use pasung, which is a form of confinement with chain or a lack of family support and suffer complications, which may lead
another medium to restrict mobilisation toward mentally ill peo- to a larger time of admission. It is unclear if malnutrition is only
a consequence or may be also a cause of depression, but its ele- Aims.– The aims of the study were to estimate the prevalence of
vated prevalence highlights the need of performing an accurate depression among university students and to examine the relation-
nutritional assessment. ship between social support and depression.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– A cross-sectional survey was conducted among students
interest statement. of human and social sciences faculty and faculty of medicine of
Tunis, between the 1st February and 31 may 2017. We assessed
depression by using the Depression Beck inventory. The perceived
E-PV0251 social support was evaluated by the Multidimensional Scale of Per-
Peripheral blood expression of ogg1, ceived Social Support.
mutyh, neil1 and apex1 in the chronic Results.– The sample included 206 students. Median age was 23
years with quartiles 21 and 26 years. Among the sample, 62.6%
mild stress model of depression and
was female and 37.4% was male. One hundred thirty five students
during pharmacotherapy using (65.5%) had a low perceived social support. Depression prevalence
venlafaxine was 41.7% among students. Results showed that 9.2% of students
P. Czarny1* , P. Wigner2 , E. Synowiec2 , J. Strycharz1 , J. Szemraj1 , M. had a severe depression. Twelve students (5.8%) reported previous
Papp3 , T. Sliwinski2 suicide attempts. We found a strongly negative and significant asso-
1 Medical University of Lodz, Department of Medical Biochemistry,
ciation between depression and perceived social support (p = 0.001)
Lodz, Poland; 2 University of Lodz, Laboratory of Medical Genetics- and a positive association between depression and suicide attempts
Faculty of Biology and Environmental Protection, Lodz, Poland; 3 (p = 0.000). No associations were found between depression and
Polish Academy of Sciences, Institute of Pharmacology, Krakow, gender (p = 0. 47), socioeconomic level (p = 0.068) and marital status
Poland (p = 0.27).
Conclusions.– Our results highlighted the need for early screening
and management of depression among students. Preventive strate-
Background and aims.– Recently, it was shown that depression is
gies to enrich the social network of students are needed.
accompanied by increased levels of 8-oxoguanine – a marker of
DNA damage. Over the past three years, our team has published
interest statement.
several papers in which we confirmed: (i) the presence of increased
DNA lesions in depressed patients; (ii) impairments of DNA dam-
age repair, (iii) modulation of depression occurrence caused by E-PV0253
the single-nucleotide polymorphisms (SNPs) of genes involved in
Cognitive impairment in patients with
base excision repair (BER), (iv) that those SNPs may contribute to
less efficient DNA repair in the patients. In current study, we used depressive disorder
chronic mild stress (CMS) model, to elucidate, whether peripheral S. Fedorová* , R. BartečekBartecek.Richard@fnbrno.cz
blood expression of genes involved in the first steps of BER, i.e. Faculty of Medicine Masaryk University and University Hospital Brno,
Ogg1, Mutyh, Neil1 and Apex1, changes during depression and after Department of Psychiatry FN Brno and LF MU, Brno, Czech Republic
the use of venlafaxine.
Methods.– 24 Wistar rats were divided into 4 groups (n = 6), i.e. Background and aims.–
controls, CMS rats, CMS rats administered with vehicle and those Introduction.– Cognitive impairment in patients with depressive
treated with venlafaxine (10 mg/kg, IP). After experiments, ani- disorder is a subject of intensive research.
mals were decapitated and RNA was isolated from their peripheral Objectives.– This study deals with the cognitive impairment in
blood mononuclear cells (PBMCs). Expression changes were esti- patients with unipolar major depressive episode and patients with
mated using TaqMan probes, 2−Ct method and 18S rRNA gene as recurrent depressive disorder during the acute state of illness.
an endogenous control. Aims.– The aim was to define main variables which influence cog-
Results.– CMS procedure caused decreased expression of Ogg1, nitive performace during the acute state of depressive episode.
Mutyh and Apex1 when compared to control rats. Interestingly, Methods.– We have used neuropsychological test battery
while pharmacotherapy did not affect expression of Ogg1 and (Auditory–Verbal Learning Test, Rey-Osterrieth Complex Fig-
Mutyh, it triggered further downregulation of Apex1. Neil1 was ure Test, Digit span test, Trail making test, Verbal Fluency Test
expressed at lower level only in rats administrated with venlafax- and Block Design) for the evaluation of the cognitive functions
ine. in patients with unipolar major depressive episode (n = 14) and
Conclusions.– Expression of BER genes may be affected by depres- patients with recurrent depressive disorder (n = 7).
sion and its pharmacotherapy. Results.– We found cognitive impairment in all examined domains
Disclosure of interest.– The authors have not supplied a conflict of in both groups of patients. More profound cognitive impairment
interest statement. was found in patients with recurrent depressive disorder, particu-
larly in visuo-constructive abilities, executive functions and verbal
memory in relation to higher age of the patient.
E-PV0252
Conclusions.– Our findings suggest higher age of the patient and
The relationship between depression repeated depressive phase as the most important variables which
and percevied social support among affects cognitive impairment.
university students Disclosure of interest.– The authors have not supplied a conflict of
R. Damak* , F. Fekih-Romdhane, R. Feki, A. Feki, M. Cheour interest statement.
Razi HOspital, Ibn Oumarne, Manouba, Tunisia

Background.– University students are a special group of people that
are enduring a transitory period in which they are going from ado-
lescence to adulthood. Depression among students have significant
impact on quality of life and academic performances.
E-PV0254 of spouse relationship problems. Likewise, it has been described

Inflammatory depression advances in that sex hormone fluctuations may contribute to heightened risk
schizophrenia (ideas): a precision for developing depressive symptoms. Also, psychoeducation for
parents through booklets in the perinatal care rooms is giving
medicine approach of the national good results. Delivery of coparenting interventions (compared to
FACE-SZ cohort relationship interventions) seem to attract more interest from cou-
G. Fond1* , O. Godin2 , P.M. llorca3 , L. Boyer1 ples and are likely to be easier to integrate into existing services.
1 Aix-Marseille Univ- School of Medicine, La Timone Medical Campus, Psychoeducational interventions in primary care for couples of
EA 3279: CEReSS - Health Service Research and Quality of Life Center, primitive women optimizes family functioning and reduces the
Marseille, France; 2 Fondation FondaMental, Epidemiology, Créteil, risk of common mental disorders in the postpartum period. Finally,
France; 3 Fondation FondaMental, Psychiatry, Clermont-Ferrand, the postpartum screening intervention for fathers could be cost-
France effective compared to no screening.
Conclusions.– The inclusion of parents in interventions for pre-
vention, promotion and treatment of mental disorders in the
Background and aims.– Major Depressive Disorder (MDD) is a ther-
postpartum period is giving good clinical, social and economic
apeutic challenge in schizophrenia (SZ). Untangling different forms
results.
of MDD appears as the best current strategy to improve response
to treatment in the so-called precision medicine approach.
interest statement.
The objectives of the present study were to determine (i) the preva-
lence of Inflammatory Depression (ID) in stabilized SZ outpatients
(ii) if ID was associated with clinical or cognitive profiles that may E-PV0256
help clinicians detecting ID (iii) if antidepressants were effective
in ID and (iv) the biological correlates of ID that may orientate
The impact of psychosocial factors on
personalized treatments. the evolution of major depressive
Methods.– Participants were consecutively included and received a disorder
thorough 2 days- clinical assessment. S. Ben Ali, Y. Zgueb, R. Jomli* , U. Ouali, F. Nacef
Results.– 785 subjects were recruited in the FACE-SZ cohort. 289 Razi Hospital, Psychiatric Departement, Tunis, Tunisia
(36.8%) were diagnosed with MDD (remitted or unremitted), of
them 57 with ID (19.7%). No clinical or cognitive features were asso-
ciated with ID (all p > 0.05). ID has been associated with increased Background and aims.–
abdominal perimeter (aOR = 4.48, p = 0.002) and latent Toxoplasma Background.– The evolution of major depressive disorder (MDD) is
infection (aOR = 2.19, p = 0.04). While Antidepressants were associ- influenced by several meteorological, biological, psychological and
ated with decreased depressive symptoms level in ID. 44% of the social factors. Thus, life events have an important role in relapsing
subjects remained unremitted under antidepressant, which were during MDD.
not associated with lowered hs-CRP blood levels. Aims.– Identify pychosocial and environmental factors associated
Conclusions.– Increased perivisceral fat and latent Toxoplasma with relapse and recurrence.
infection are both potentially related to gut/microbiota distur- Methods.– We realize a retrospective study at the psychiatric
bances. Specific anti-inflammatory drugs and microbiota-targeted departement A in the Razi universal hospital.
therapeutics appear as promising strategies in the treatment of A data sheet was used to collecte socio-demographic and clinical
inflammatory depression in schizophrenia. characteristics of 34 patients who was hospitalsed for a depressive
Disclosure of interest.– The authors have not supplied a conflict of episode.
interest statement. Results.– The average age was 47.58. The sex ratio was 0.03.
The unemployment rate was 61%. The main psychosocial and
environmental problems found were problems with the main sup-
E-PV0255 port group (85.66%) economic problems (17.33%) and professional
problems (13.2%). The average of hospitalization for the patients
Postnatal depression in fathers.
presenting these problems was 6.9 against 3.1 for the patients with-
Systematic review of recent clinical out this type of problems.
trials Conclusions.– Life events have a definite impact on the evolution
G. Hernandez-Santillan1* , G. Lahera-Forteza2 , M.F. Bravo-Ortiz3 and management of depressive disorder. their identifications is
1 University Hospital Principe de Asturias, Psychiatry Unit, Madrid, necessary.
Spain; 2 University of Alcala, School of Medicine, Madrid, Spain; 3 Disclosure of interest.– The authors have not supplied a conflict of
University Hospital La Paz, Psychiatry Unit, Madrid, Spain interest statement.
Background and aims.– Introduction: In contrast to the vast knowl- E-PV0257

edge in mothers, postpartum depression in parents is still a “spot
blind”. However, its approach is gaining more interest at the sci-
Suicidility features among Tunisian
entific and clinical level given the reversible effects of its timely patients with mood disorders
intervention. L. Jouini* , U. Ouali, Y. Zgueb, R. Jomli, F. Nacef
Objectives.– To analyze clinical trials about postnatal depression in Razi Hospital- La Mannouba- Tunisia, Psychiatry Department “A”,
fathers. Tunis, Tunisia
Methods.– Systematic search of clinical trials in the last 5 years pub-
lished in Pubmed and Embase. Keywords: men, father, depressive,
Background and aims.– Suicidality is common among psychiatric
depression, postpartum, postnatal.
patients suffering from mood disorders. Its severity can vary from
Results.– 11 clinical trials were found in Pubmed and 12 in Embase.
a simple desire to die to repetitive suicidal attempts. The aim of
It has been found that, after childbirth, almost continuous skin-
our study was to explore the different features of suicidality among
to-skin contact decreases infants cortisol reactivity in response
Tunisian patients with mood disorders and to determine associated
to handling and improves the concordance between mothers and
factors.
infants ‘salivary cortisol levels, and decreases fathers’ experiences
Methods.– Patients with a diagnosis of depression (n = 150) were increased mortality from natural causes over 11 years in an elderly
interviewed using the Structured Clinical Interview for DSM IV for community-dwelling cohort.
mood disorders. Patients then received a diagnosis of Major Depres- Methods.– The data of this research is covered in 4 township in
sive Disorder (MDD) or Bipolar Disorder (BD). Patients were asked Taiwan. Before 11 years ago, senior citizens who are during 65
about their suicidality features during their depressive episodes: to 74 years old. The total amount of the citizens is 900. Then, we
their desire to die, their suicidal thoughts, their suicidal attempts use Taiwan Depression Questionnaire to screen the depression and
and if they had a precise suicide project or not. suicidal ideation. The analytical statistics of this research use mul-
Results.– Patients were diagnosed with MDD (58.7%, n = 88), BD tivariate logistic regression with robust standard errors.
(39.3%, n = 59) and NOS (2%, n = 3). A history of suicide attempt was Results.– After chasing 11 years, there are 239 seniors died, 593
reported by 25.3% (n = 11) of patients. Suicidality features during seniors still alive, and 68 seniors can’t keep chase. After con-
depressive episodes were as follows: desire to die (36%, n = 54), trolling the demographic data, We found the presence of suicide
suicidal thoughts (19.3%, n = 29), suicidal attempts (11.3%, n = 17), ideation was significantly associated with 10-year-mortality in the
having a precise project (8%, n = 12). Men had significantly more elderly (odds ratio 1.622, 95% confidence interval: 1.042–2.525).
suicidal thoughts than women (p = .015). The diagnosis of BD was Besides, the depressive symptoms was not significantly associated
more predictive of suicidal attempts than MDD and DD (p = 0.022, with 10-year-mortality (odds ratio 0.982, 95% confidence interval:
p = 0.017). The presence of mixed features was significantly asso- 0.962–1.002).
ciated with less suicidal thoughts (p = 0.041). A history of suicide Conclusions.– The results of the study showed a significant effect
attempt had a strong association with current suicide attempts of suicidal ideation on all-cause mortality. It may be due to poor
(p = 10-3) and with a precise project (p = 0.08). health behavior, which would suggest that individuals less likely
Conclusions.– Identifying the factors related to suicidality among to seek appropriate health care. We found that suicidal ideation
Tunisian patients with mood disorders may improve the clinical instead of depressive symptoms predict 10-year all-cause mortal-
assessment of suicide risk in people with depression. ity in the community elder population. It may be due to the stigma
Disclosure of interest.– The authors have not supplied a conflict of of depressive disorder. In Taiwan, the elderly usually felt embar-
interest statement. rassed to say they are in low mood or depression. But they admit
they had ideation of death or worthlessness. It may result in this
consequence.
E-PV0258 Disclosure of interest.– The authors have not supplied a conflict of
The depression profile among interest statement.
Moroccan drug addicted
K. Karjouh1* , F.Z. Azzaoui1 , A. Ahami1 , S. Boulbaroud2 , I. Jaouahir1
1 E-PV0260
Unit of Clinic and Cognitive Neurosciences and Health Laboratory of
Biology and Health, Department of Biology Faculty of Science- Effect of treatment with escitalopram
University Ibn Tofail- Kenitra- Morocco, Kenitra, Morocco; 2 on the composition of intestinal flora
Polydisciplinary Faculty- Beni Mellal- Morocco., Department of in patients diagnosed with depression
Biology, Beni Mellal- Morocco, Morocco P. Liśkiewicz1* , J. Pełka-Wysiecka1 , M. Wroński1 , A. Baba-Kubiś
˛ 1 , I.
* Corresponding author. 2 1
Łoniewski , J. Samochowiec
1 Pomeranian Medical University in Szczecin, Department of
Psychiatry, Szczecin, Poland; 2 Pomeranian Medical University in
Introduction.– Drug abuse represents a major public health prob-
Szczecin, Departament of Biochemistry and Human Nutrition,
lem around the world. Different psychological schemas can be
Szczecin, Poland
disrupted during this neuropsychological disorder, such as the * Corresponding author.
depression, that could drive the patient into relapse or suicide.
Objective.– To assess the depression profile among addicted persons Background and aims.– Despite the broad spectrum of pharmacolog-
to illicit substances in the city of Rabat, Morocco. ical and non-pharmacological treatment methods for depression,
Methods.– Cross-sectional study is conducted among 120 addicted a significant percentage of patients are drug-resistant or present
persons, aged between 18 and 42 years old. The Depression profile insufficient therapeutic response. This indicates that the path-
is evaluated by the Beck Depression Inventory (BDI-II). omechanism of the disease is not fully understood. It needs to
Results.– The results indicated that 70% of the studied population be analyzed at the microbiological, immunological and endocrine
have a depressive profile; 20% of participants had a mild depres- level. Recent reports suggest that abnormalities of the microbiome
sion, 36.7% obtained a moderate depression and the other 13.3% and malfunctioning of the intestinal barrier are involved in the
had severe depression. pathogenesis of depression. Findings so far have proved insuffi-
Conclusions.– A significant proportion of depressive symptomatol- cient. New biological facts could therefore lay the groundwork for
ogy was revealed among this population. An in-depth study of the innovative disease concepts and creation of more effective treat-
factors involved in the manifestation of this behavioural imbalance ment methods.
is underway. The aim of the study was to demonstrate that therapy with
Disclosure of interest.– The authors have not supplied a conflict of an antidepressant in patients suffering from depression leads to
interest statement. changes in the bacterial composition of the intestinal flora.
Methods.– The study included 20 somatically healthy patients
diagnosed with depressive episode according to the ICD-10. Psy-
E-PV0259 chometric tests were performed before and after 2, 4, 6 weeks of
The relationship between suicide taking escitalopram, the composition of bacterial intestinal flora
ideation and all-cause mortality in was assessed before and after 6 weeks of pharmacotherapy.
community-dwelling elders Results.– The study confirmed shifts in bacterial composition of the
P.C. Lin* , Y.C. Yen intestinal microflora in patients diagnosed with depressive episode
EDA Hospital, Department of Psychiatry, Kaoshiung, Taiwan R.O.C. after treatment with escitalopram.
* Corresponding author. Conclusions.– The results have been promising so far and they need
further research.
Background and aims.– The aim of our study was to prospec- Disclosure of interest.– The authors have not supplied a conflict of
tively examine whether suicidal ideation was associated with interest statement.
E-PV0261 were achieved by obtaining a coefficient of correlation between the

Thyroid hormone treatment in the scores at discharge for each patient.
management of treatment-resistant Results.– Out of 95 patients who completed both the GDS and BDI-II,
68.4% achieved full remission on the GDS and 33.7% achieved partial
unipolar depression: a systematic remission. On the BDI-II, 80% of patients achieved full remission
review and meta-analysis and 17.9% achieved partial remission. 4/95 patients improved on
R. Lorentzen1* , J.N. Kjær2 , S.D. Østergaard3 , M.M. Madsen2 the GDS but worsened on the BDI-II. 2/95 patients were unchanged
1 Aarhus University, Faculty of Health, Aarhus, Denmark; 2 Aarhus on either scale.
University Hospital, Risskov, Aarhus, Denmark; 3 Aarhus University Conclusions.– In this evaluative study, only four patients reported
Hospital and Aarhus University, Department of Clinical Medicine, worsening of their symptoms when the team made an evaluation
Aarhus, Denmark of improvement. The rest who did not feel improved did not show a
response to the interventions. This high level of concordance does
not rule out the presence of ‘personality factors’ in this cohort, but
Background and aims.– Treatment-resistance is of significant clini-
they were certainly not responsible for ‘treatment- resistance.’
cal concern, affecting approximately 40% of patients with unipolar
depression. Treatment with thyroid hormones is occasionally used
interest statement.
in the management of treatment-resistant or refractory depres-
sion, however, the evidence for the effect of this pharmacological
intervention is not fully established. In this study, we aim to sys- E-PV0263
tematically review the literature on the effect of thyroid hormone
treatment in the management of treatment-resistant unipolar
Depression in elderly hemodialysed
depression. patients: multicentric study in the
Methods.– The study is registered at PROSPERO and we follow South of Tunisia
the PRISMA guideline for systematic reviews and meta analy- M. Trigui1 , Y. Mejdoub1 , L. Ghanmi2 , M. Maalej3* , J. Jdidi1 , M. Ben
ses. Searches were carried out on the 27th of August 2018 in the Hmida1 , R. Boukhchina2 , S. Deymi4 , A. Abdennour5 , M. Abbes2 , S.
MEDLINE (PubMed), EMBASE and PsycINFO databases. No restric- Yaich1 , L. Zouari3 , J. Damak1 , M. Maalej3
1 Hédi Chaker University Hospital, Department of Community
tions on language or publication date were applied. Each record
is screened independently by at least two authors. In the case of Medicine, Sfax, Tunisia; 2 Regional Hospital of Gabes, Department of
discrepancies, consensus will be reached upon discussion. Data Psychiatry, Gabes, Tunisia; 3 Hédi Chaker University Hospital,
extraction will be performed independently by at least two authors. Department of Psychiatry “C”, Sfax, Tunisia; 4 University Hospital of
Again, in the case of discrepancies, consensus will be reached upon Medenine, Department of hemodialysis, Medenine, Tunisia; 5
discussion. National Health Insurance Fund, National Health Insurance Fund,
Results.– The search yielded 1323 records, of which 419 were dupli- Tataouine, Tunisia
cates. Abstract and full text screening of the 904 remaining records
is currently underway and will be followed by data extraction. Pre-
liminary results will be presented at the EPA Congress 2019. Background and aims.– Depression is commonly noted in elderly
Conclusions.– We expect that the findings of this study will be of hemodialysed patients (EHP) and is associated with both an
relevance for psychiatrists managing treatment-resistant unipolar impaired quality of life and increased morbidity and mortality. We
depression. aimed to assess the frequency of depression in EHP and to identify
Disclosure of interest.– The authors have not supplied a conflict of the factors associated with depression among this population.
interest statement. Methods.– We conducted a multicenter cross-sectional study in the
South of Tunisia, during the month of October 2017. Were included
all patients older than 65 years, with a chronic renal failure under-
E-PV0262 going periodic hemodialysis. We collected data by a semi-directive
interview of the patient and a member of his family.
Labeling ‘personality factors’ as the
Results.– A total of 81 patients were included. At the time of the
reasons for ‘treatment-resistance’ in survey 67% of the patients had a depression. Depression was sig-
mood disorders in older adults may be nificantly associated with: illiteracy (p = 0.02), the lack of physical
an attribution error activity (p = 10-3), the absence of recreational activity (p = 0.003),
A.S. Luthra1* , T. Semplonius2 , H. Millman3 , S. Remers4 the presence of a stressor in the last 6 months (p = 0.035), the lack
1 McMaster University, Behavioural Neuroscience, Hamilton, Canada; of autonomy (p = 0.002), the presence of a motor deficit (p < 10-3),
2 McGill University, Medicine, Montreal, Canada; 3 Homewood the presence of a physical comorbidity (p = 0.003), predialytic crea-
Health Centre, Program for Older Adults, Guelph, Canada; 4 tinine 800 ␮mol/l (p = 0.018), hypoprotidemia (p = 0.002) and the
Homewood Health Centre, Research and Outcomes, Guelph, Canada presence of cognitive disorders (p < 10-3).
* Corresponding author. Conclusions.– We found that depression was common in our pop-
ulation and we identified several risk factors. It is, therefore,
Background and aims.– Preliminary data from a ‘naturalistic study’ important to develop systematic approaches to detecting depres-
identified ‘disease factors’ (course and index episode specifiers and sion in hemodialysed patients, and to develop strategies, taking into
trends in diurnal variation) as the primary reason for ‘treatment- account risk factors for the proper management of these patients.
resistance’ among the patients in the Program for Older Adults Disclosure of interest.– The authors have not supplied a conflict of
at Homewood Health Centre- an addictions and mental health interest statement.
facility in Guelph, Canada. Based upon the outcome of this study,
we hypothesize that labeling ‘personality factors’ as reasons for
‘treatment-resistance’ may be an attribution error and a default E-PV0264
position. Psycho-social problem: my time with
Methods.– Treatment response was measured in ‘subjective’ and
‘objective’ domains, using the Beck’s Depression Inventory (BDI-II)
cancer
N. Mandal
to capture the ‘subjective’ response, and the Geriatric Depression
Narikeldaha Prayas, Oncology, East Medinipur, India
Scale (GDS) to capture the ‘objective’ response. Both measures were * Corresponding author.
taken to ensure concordance between the two sets of results, and
Background and aims.– Two months before my 16th birthday, I E-PV0266

was preparing for a weekend with my mom to choose a dress Post-stroke depression –
for my college fresher ceremony. When I went to bed, my body
pathophysiological mechanisms and
ache, headache happened, so I took some pain killer and went to
sleep. After being in so much pain that I was unable to sleep, I
treatment
walked from my room to the kitchen to get a glass of water to take M. Mendonça Bettencourt
more medicine, and that’s when it hit me. My physical problems Unidade Local de Saúde do Nordeste, Departamento de Psiquiatria e
were removed but unable to sleep due to psycho-social problems. Saúde Mental, Bragança, Portugal
Because, I have diagnosed cancer. My aim is to evaluate the emo-
tional distress in cancer patients, including depression, anxiety, and Background and aims.– Depression is the most frequent neuropsy-
suicidal ideation. chological complication following cerebrovascular disease. It may
Methods.– Home visit by volunteers and enumeration of the prob- compromise recovery and rehabilitation in this population, increas-
lems as discussed by the patient and their families. Simultaneously ing mortality significantly.
I visited my oncology clinic and try to relate my problems with This work is a nonsystematic review about Post-Stroke Depres-
them. sion which aims to explore its pathophysiological mechanisms,
Results.– Analysis the following data and identify these main prob- whether there’s a correlation between the stroke location and PSD
lems. and what’s the state of the art concerning its treatment.
Patient problems, family problems and Psycho-social problems. Methods.– A search using the terms “post-stroke” and “depression”
Lack of awareness of the neighbor of local people about cancer and was conducted in Pubmed, selecting articles written in English and
palliative care resulting in isolation of the family. published in the last five years.
Conclusions.– We believe that if we are able to continue our program Results.– Post-stroke depression prevalence rates range widely due
for a long enough periods the suffering of the cancer patient and to methodological disparities between different studies. Diagnosis
their families might be resolved to a large extent over time. Social is complex due to other symptoms that can be associated, such as
effort to raise the awareness of neighbors and local people through aphasia or agnosia. The use of some diagnostic tools can be useful.
discussion and other audio visual method (i.e. poster, leaflet, slide Several mechanisms are involved in its pathogenesis, namely bio-
presentation, etc) will be break the social stigma for cancer. logical, behavioral and social ones. There’s not enough evidence to
Disclosure of interest.– The authors have not supplied a conflict of support a correlation between laterality of ischemic lesion and risk
interest statement. of developing PSD. There’s evidence, however, that leukoaraiosis
and lacunar strokes play a role in its pathogenesis. Inflamma-
tory processes may also be involved. PSD treatment of choice are
E-PV0265
selective serotonin reuptake inhibitors, due to efficacy as well as
Clinical and psychopathological tolerability.
features of early and late dysthymia Conclusions.– PSD is a common problem in daily practice. However,
N. Maruta* , V. Fedchenko is currently underdiagnosed and undertreated. Neurologists and
“ Institute of Neurology- Psychiatry and Narcology of the NAMS of
other doctors dealing with patients who suffered a stroke should
Ukraine” SI, borderline mental pathology, Kharkiv, Ukraine be aware of its existence and deleterious consequences and capable
of recognizing its symptoms and treating it, or at least suspect of
its presence and ask for a specialist’s evaluation.
Background and aims.– Depressive disorders are the most com- Disclosure of interest.– The authors have not supplied a conflict of
mon forms of mental illness with significant medical and social interest statement.
consequences and require adequate and timely medical care. An
important aim on this path is to study their peculiarities of the
course. E-PV0267
Methods.– To realize the goals and objectives of the study, an inte-
Disorder-specific and transdiagnostic
grated approach including clinical and psychopathological (study
of complaints, clinical history, psychopathological condition and its functional neuroimaging
dynamics), psychometric (Hamilton’s scale - HDRS) methods was abnormalities in major depressive
used. 38 patients with dysthymia were examined (F 34.1). disorder
Results.– The study of the effect of the onset of the disorder on C. Miller1,2* , P. Hamilton3 , I. Gotlib1
the structure of clinical symptoms showed that the early onset 1 Stanford University, Department of Psychology, Stanford, USA; 2
of dystymia (up to 30 years) leads to the formation of hypochon- California State University- Fresno, Psychology, Fresno, USA; 3
dria (r = 0,387), early insomnia (r = 0,369), and disorders in the Linkoping University, Department of Clinical and Experimental
field of work and activity (r = 0,327). While the later onset of dys- Medicine, Linkoping, Sweden
thymia (after 30 years of age) affects the formation of common * Corresponding author.
somatic symptoms (in particular, a sense of energy loss or loss of

strength) (r = 0.428), insomnia of the middle (restless night sleep) Background and aims.– A large body of research using functional
(r = 0.405), mental anxiety (r = 0.363). It has been established that magnetic resonance imaging (fMRI) has documented numerous
atypical dystymia is more likely to be characterized by apatitic differences between patients diagnosed with major depressive
and hypochondriaal syndrome complexes (p < 0,05), while distal- disorder (MDD) and healthy controls. It is not known, however,
phobic and somato-vegetative syndrome complexes (p < 0,05) with whether these neuroimaging abnormalities are specific to MDD or
a later onset. are shared across psychiatric disorders. This study aims to advance
Conclusions.– The influence of the age of the onset of dystymia on our understanding of MDD by (1) identifying the most reliable
the structure of clinical symptoms is revealed and individual lead- neural abnormalities observed in fMRI studies of MDD and (2)
ing syndromes are identified, which has a prognostic significance determining which of these neural abnormalities are depression-
for the selection of adequate therapeutic tactics. specific and which are shared across other mood and anxiety
Disclosure of interest.– The authors have not supplied a conflict of disorders.
interest statement. Methods.– This study uses a voxel-wise, whole-brain, coordinate-
based meta-analytic approach with ensemble thresholding to
identify neural abnormalities observed in fMRI studies of MDD
(N = 66 studies, 2463 subjects) and to compare these results with E-PV0269

another mood disorder [bipolar disorder (BPD): N = 15 studies, 562 Postpartum depression in males:
subjects] and anxiety disorder [generalized anxiety disorder (GAD):
a case report
N = 15 studies, 510 subjects].
M.T. Ponte Lopez* , S. Boi, J. Herranz Herrer, M. Martín García, E. Gil
Results.– The results of this study indicate that statistically sig-
Benito, B. Sanz-Aránguez Ávila
nificant (p < 0.0001) clusters of hyperactivity and hypoactivity are
Hospital Universitario Puerta de Hierro, Psiquiatría, Madrid, Spain
related reliably to depression but not to mania or anxiety and * Corresponding author.
should be regarded as candidates for depression-specific biomark-
ers. Conversely, other neural abnormalities (p < 0.005) are shared Background and aims.– Puerperium women’s mental health has
across groups of individuals with MDD, BPD, and GAD and should drawn research attention in the late years. However there are few
be regarded as transdiagnostic biomarkers of mood and anxiety parenthood mental health trials available.
disorders. Methods.– We present a case report of a 41 years old father of
Conclusions.– This study provides the first large-scale and meta- a 4 years old and a newborn girl. He showed low and unstable
analytic evidence of disorder-specific neural abnormalities in MDD mood, insomnia and elevated anguish during the last weeks that
and represents an important step toward a disease-based model increased after the birth, a week ago, adding then harm, ruin and
of depression capable of differentially diagnosing depression on guilt delusional ideas, related mostly to the newborn.
the basis of its underlying neuropathology and suggesting novel, In psicopathologic examination perplexity, suspicion, hypomimia,
disorder-specific neural targets for intervention. sparing languaje with increased response latency and mood-
Disclosure of interest.– The authors have not supplied a conflict of coherent delusions was outlined.
interest statement. Results.– Negative organic screening was shown. Diagnosis was
severe depressive episode with psychotic symptoms on the basis
of wife’s postpartum. There were coincidental precarious labour
E-PV0268 and economic situation and anancastic personality traits, high self-
The role of anhedonia in depressive demand and sense of responsibility that triggered the mentioned
disorder symptomatology.
A. Pérez Morenilla1* , A. Salaza Couso2 , I. Failde Martínez2 , J.A. Conclusions.– Postpartum depression can happen to one in ten men,
Micó Segura3 being mother’s depression a major risk factor according to several
1 Psychiatrist, Psychiatry and Mental Health, Cádiz, Spain; 2 studies. There are some differences regarding symptomatology and
University of Cádiz, Department of Epidemiology and Public Health, causes. It would be valuable to consider both parents mental healt
Cádiz, Spain; 3 University of Cádiz, Department of Neuroscience state during pregnancy and postpartum, specially in previous social
Pharmacology and Psychiatry- CIBERSAM Group G18- INIBICA or economic lack situations and other vulnerability factors. This
Instituto Investigación Biomédica de Cádiz, Cádiz, Spain could allow to pick patients subsidiary to pharmacological or psy-
* Corresponding author. cological treatment as well as to diminish the sickness comorbidity
risks in the child’s development.
Background and aims.– One every four has a diagnosable mental Disclosure of interest.– The authors have not supplied a conflict of
disorder, in which Depression is the most frequent. The importance interest statement.
of Depressive Disorder (DD) lies in the high disability and impact
on the quality of life that it causes on these patients, greater eco-
nomic costs and use of health resources and important morbidity E-PV0270
and mortality; all of which makes it a public health problem. DD Depression, search for new challenges
is characterized by changes in affect (depressed mood and/or loss in treatment
of interest or anhedonia), as well as impairments in cognition and
M. Soto Laguna* , G. Belmonte Garcia, M. Fernández-Torija Daza, A.
neurovegetative functions (somatic symptoms).
Sanchez Cabezudo, F.J. Gonzalez Diaz
Methods.– Anhedonia, defined as “inability to experience pleasure,”
Complejo Hospitalario de Toledo, Psiquiatria, Toledo, Spain
is a symptom present in patients with depressive disorder. Somatic * Corresponding author.
symptoms also appear as fundamental symptoms in patients with
DD. From a neurobiological point of view, both share multitude Background and aims.–
of brain structures and neurotransmission systems, particularly Introduction.– Depression is one of the most disabling diseases of
Monoaminergic System. the 21st century.
Results.– The presence of both symptoms has been related to a Early recovery avoids chronic symptoms.
worse prognosis of DD, lower remission rates, higher recurrence, Currently the patient not only seeks an improvement of mood but
longer duration of the depressive episode, worse antidepressant also the social aspect, work, relationship and sexual area.
treatment results, greater use of Health Services and worse quality Goals.– In the Hospital of Toledo (Spain), a study was carried out
of life related to health. to check the improvements in affective, anxiety and cognitive sta-
Conclusions.– Anhedonia seems to be undoubtedly a nuclear symp- tus in patients with 3 types of antidepressants: selective serotonin
tom in DD, as well as somatic symptoms, without knowing how reuptake inhibitors, antidepressants dual and a multimodal antide-
they relate to each other until now. Based on these data, it would pressant (vortioxetine).
be recommended to carry out researches to elucidate the impli- Methods.– Our inclusion criteria were: being over 18 years of age,
cation of the presence or absence of anhedonia in the rest of the diagnosis of depression or Adaptive Disorder according to DSM-V
dimensions (affective, cognitive and somatic, especially pain) in criteria, not having received antidepressant treatment in the last
depressed patients, as well as their involvement on the quality of year, not presenting intellectual disability, signing the informed
life related to health. consent.
Disclosure of interest.– The authors have not supplied a conflict of The Montreal Cognitive Assessment (MOCA) scales for cognitive
interest statement. aspects, the Montgomery-Asberg Depression Rating Scale (MADRS)
for depressive symptoms and the Hamilton scale for measuring
anxiety have been used.
Results.– The data analysis was through the SPSS program the data
analysis was carried out.
Similar results were obtained in treatment with any of the three Methods.– N = 60 (44 female, mean age 27 ± 7 years). The partic-
antidepressants in anxiety symptoms, the depressive symptoms ipants completed a Russian version of Beck Depression Inventory
improved more significantly with dual antidepressants and with (BDI-II) with scores ranging from 0 to 26 (M = 7.5, SD = 6.6) and per-
the multimodal antidepressant and the cognition improved with formed the Internal Shift Task. To assess the effects of sub-clinical
the multimodal antidepressant depression, we median-splitted (Me = 5.5) the sample giving a
Conclusions.– Currently the treatment of depression implies a euphoric and a non-euphoric group.
greater ambition in the recovery of all areas of life of the patient Results.– We found a Group × Valence interaction, F (1, 58) = 4.48,
in the shortest time in the search for complete recovery. p < 0.05, confirming the result of the previous analyses – the
Our results indicate better functionality with dual antidepressants euphoric group was characterized by reduced RTs during the pro-
and vortioxetine. cessing of angry faces.
Disclosure of interest.– The authors have not supplied a conflict of Conclusions.– We found typical effects of stimuli emotionality
interest statement. (emotional materials being processed more slowly) and switching
(the change of a stimulus category leading to slower processing).
More importantly, we found no signs that presenting a negative
E-PV0271 stimulus in the previous probe selectively impairs processing in
Use of aripiperazole in late life the subsequent probe in subjects with more depressive symptoms.
depression: case note review However, we found that non-dysphoric subjects exhibit a protec-
S. Srivastava* , A. Sonal, P.K. Chaubey, A. Singh tive bias away from negative information processing the negative
King George’s Medical University, Geriatric Mental Health, Lucknow, stimuli more quickly than neutral stimuli.
India Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– The response rates in depression are as low

as 30% to first line antidepressants. Thus, there is need for newer E-PV0273
pharamacological agents to be used either as monotherapy, or in Postnatal depression among tunisian
conjunction with traditional antidepressants to achieve remission mothers of newborns hospitalized in
earlier. Aripiperazole is one such drug which has been used as aug-
the neonatal intensive care unit
mentation therapy in treatment resistant cases. However, its use
S. Taleb, S. Bourgou, A. Taamallah* , M. Hamza, F. Charfi, A. Belhadj
from the beginning of the treatment - either in conjunction with
Mongi Slim Hospital, Child and adolescent Psychiatry, Tunis, Tunisia
another antidepressant or on its own, has not been studied. * Corresponding author.
Methods.– In the outpatient walk-in clinic, patients over the age
of 60 years are referred from other departments of the University, Background and aims.– The separation of mother -infant dyad at
psychiatrists practicing elsewhere, or by themselves. In additionto birth, because of the newborn baby’s need for intensive medical
the usual history, cognitive screening on Hindi Mental State Exam- attention, is an unexpected and traumatic event for the mother. It
ination is done on all patients, the depressed patients are also may affect maternal mental health and so the infant’s development.
evaluated on Hamilton Rating Scale for Depression (HAMD) and The study aimed to investigate levels of postpartum depression
Geriatric Depression Scale (GDS). On subsequent visits, the patients among mothers whose babies were hospitalized at birth in the
are rated on HAMD and GDS. neonatal intensive care unit (NICU) of the Mongi Slim hospital in
Results.– Over 2 years, 53 patients (37 male, mean age 68 years) Tunisia. We also tried to determine maternal/infant characteris-
were prescribed aripiperazole - either given alone or in combi- tics that predict risk for developing postpartum depression in these
nation with an antidepressant from the first visit onwards, or as mothers.
add-on medication if first line medication was not effective. The fol- Methods.– It was conducted by the Child psychiatry department
lowup period varied between 1 week to 1 year for all the patients, of Mongi Slim hospital (Tunisia). Socio-biographical and gynaeco-
but in the present report only the data for the first 12 weeks will logical characteristics were collected from Medical Files. Mothers
be presented. completed the validated Arabic version Edinburgh Post-Natal
Conclusions.– The efficacy of aripiperazole in a clinical setting is Depression Scale (EPDS).
reported here as it can be a useful adjunct to first line antidepres- Results.– We included 22 mothers. The mean age of participants
sants. was 30, 45 years. Most of them have an average socioeconomic
Disclosure of interest.– The authors have not supplied a conflict of conditions. Pregnancy was induced for three mothers. Six of them
interest statement. have presented complications during pregnancy and four required
hospitalization in a gynecology ward. Delivery was by caesarean
section in the majority of cases (15). Caesarean section was urgently
E-PV0272 needed for 10 of them. The average duration of hospitalization of
Depression and negative emotional the newborn is 10.6 days. The mean EPDS score was 17, 2. Nineteen
interference in working memory mothers had scores equal or superior to 11, which is an indicator
F. Sultanova* , B.B. Velichkovsky, A.A. Kachina, G.E. Rupchev of postnatal depression.
Lomonosov Moscow State University, Psychology, Moscow, Russia Conclusions.– Mothers of NICU-hospitalized infants are emotion-
* Corresponding author. ally vulnerable. Determining risk factors can Help Therapists detect
and manage early the postpartum depression and help mothers to
Background and aims.– Depression is an important negative condi- establish a healthy relationship with their babies.
tion and may significantly affect the life of people. As depression Disclosure of interest.– The authors have not supplied a conflict of
has a significant cognitive component, a specific focus on the cog- interest statement.
nitive mechanisms of depression is warranted (Snyder, 2013). We
replicated the study of De Lissnyder et al. (2012) to check whether
there is an association between the sensitivity to negative emo-
tional interference in working memory and depression level in a
non-clinical sample.
E-PV0274 Results.– She has a coherent speech, against the concentration

Anxiety as a state and as a trait in difficulties, attention stability and selectivity, with psychic focus
people diagnosed with a depressive on delusion area, on xenopathy and delusional interpretativity of
daily life phenomena. Events chronology (initial mood change in
episode the depressive sense, of endo-reactive colours, undetected and
P. Maruszewska, A. Skiba, J. Jasionowska, M. Talarowska* , P.
untreated, followed by the association of psychotic elements) dic-
Galecki
tates the affective colours of disorder, in the detriment of delusional
Medical University of Lodz, Department of Adult Psychiatry, Lodz,
disorder diagnosis, even if the age can facilitate the evolution in any
Poland
of the two zones. The alteration of social functioning would be the
second criteria, in longitudinal follow-up the patient’s evolution
Background and aims.– Anxiety is one of the most common symp- highlighting the resumption of daily activities at the same socio-
toms accompanying depression. The aim of the study was to check occupational level reached previously, after mood normalization.
whether variables such as occurrence of depression, severity of Conclusions.– As princeps psychological elements, we encounter
depression symptoms and gender differentiate the subjects in the the fear of loneliness, the need for affection and listening, vari-
scope of anxiety understood as a situational state of the individual ous pains with migratory character at somatic level, the need for
and in the scope of anxiety as a permanent personality trait. emotional support.
Methods.– Thirty-nine people (31 women and 8 men) took part Disclosure of interest.– The authors have not supplied a conflict of
in the experiment. Twenty of them met the criteria of a depres- interest statement.
sive episode, while 19 individuals not treated psychiatrically were
qualified to the control group. Hamilton Depression Rating Scale
E-PV0276
was used to assess the severity of depression symptoms, while
State-Trait Anxiety Inventory was applied to investigate the level Nicotine as augmentation agent in
of anxiety. depression and anxiety
Results.– Analyses revealed statistically significant differences G. Tzeferakos1 , M. Dimitraka2 , D. Petsas3 , P. Papdimitriou4 , A.
between the individuals with diagnosed depression and the healthy Gatos- Gatopoulos4 , C. Tsopelas5*
1 University of Athens- Medical School- 2nd Dept. of Psychiatry,
subjects in terms of the level of anxiety as a state (p = 0.00) and as a
trait (p = 0.00). No statistically significant differences were found University of Athens- Medical School- 2nd Dept. of Psychiatry, athens,
related to gender and the level of anxiety as a state (p = 0.7) or Greece; 2 Psychiatric Hospital of Attica, 5th Psychiatric Dept., Athens,
the level of anxiety as a trait (p = 0.54). There were also no signif- Greece; 3 Psychiatric Hospital of Attica, 4th Psychiatric Dept., Athens,
icant differences between the severity of depression and the level Greece; 4 5th Psychiatric Dept. Psychiatric Hospital of Attica, 5th
of anxiety as a state (p = 0.57) and as a trait (p = 0.37). Psychiatric Dept. Psychiatric Hospital of Attica, Athens, Greece; 5
Conclusions.– The level of anxiety both as a trait and as a state Psychiatric Hsopital of Attica, 5th Psychiatric Dept., Athens, Greece
is higher among people with diagnosed depression than among
healthy individuals. Neither the severity of depression symptoms
nor gender is associated with the level of anxiety as a state and as Background and aims.– Current evidence suggests that Nicotine can
a trait. be used as augmentation in depression and anxiety. Acetylcholine
Disclosure of interest.– The authors have not supplied a conflict of nicotinic systems and serotonergic systems are known to interact.
interest statement. In this review we are trying to explore the possibilities of nicotine
use as a therapeutic agent in depression and anxiety.
Methods.– Thorough research of the main databases, and web
E-PV0275 search engines such as Goggle, for relevant studies, using appropri-
ate keywords. We scrutinize them independently, before reaching
Particularities of the productive
consensus about appropriateness.
phenomenology in the major Results.– In non smokers, drug naïve patients diadermal administra-
depressive episode fregoli delusions tion of 17.5 mg nicotine for 4 days reduced depressive symptoms;
and olfactory hallucinations 3.5 mg nicotine TTS for 8 days reduced depressive symptoms in
S. Trifu1* , E.G. Carp2 , M. Dragoi3 other study. But other studies reported reverse of these positive
1 University of Medicine and Pharmacy “Carol Davila”, Neurosciences results after cessation of nicotine. Chronic nicotine or cigarette use
- Psychiatry, Bucharest, Romania; 2 Hospital for Psychiatry, results in decreased monoamine oxidase A and B activity and a
Psychiatry, Sapunari, Romania; 3 Hospital for Psyhciatyr “Alex. substantial reduction in alpha -sub-4beta -sub-2 nicotinic acetyl-
Obregia”, Psychology, Bucharest, Romania choline receptor (nAChR) availability in thalamus and putamen.
* Corresponding author. The desensitization of DRN 5-HT neurons after chronic single daily
injections of 1 mg/kg of nicotine suggests an antidepressant-like
Background and aims.– The trigger is represented by the death of effect of chronic nicotine. Antidepresant effect was quick in onset
her father six months before, the case particularity consisting in of action, but requires continous use.
the association with psychotic phenomena of delusional interpre- Conclusions.– Nicotine has complex interactions with other neu-
tativity, with Fregoli delusions and olfactory hallucinations, which rotransmitters in the brain. Investigations into the neurobiology,
imposes a first differential diagnosis with cerebral organicity. and biophysical and pharmacological properties of nicotinic acetyl-
Methods.– The predominantly delusional ideation, the interpreta- choline receptors (nAChRs), have led to an improved understanding
tivity, auditory, olfactory and visual hallucinations and delusions of their role in a variety of neuropsychiatric disorders for the treat-
dictated the hospitalization. Combined antidepressant and antipsy- ment of depressive and anxiety symptoms not only to smokers after
chotic treatment has been initiated. Personality has been evaluated abstinence but also to non smokers
as regards deep functioning, being highlighted the dependency and Disclosure of interest.– The authors have not supplied a conflict of
existential insecurity area. Both psychological and projective inves- interest statement.
tigation has been used, as well as the psychometric one, by clinical
scales. She has been psychiatrically monitored and emotional sup-
port has been offered following psychodynamic exploration.
E-PV0277 Methods.– The study was carried out with 44 women who were
Patient reports about emotional 16 weeks and older pregnant and 255 puerperant who applied
meanings on refractory to the health center. As measuring tools; sociodemographic data
form, State-Trait Anxiety Inventory, Edinburgh Postnatal Depres-
pharmacological treatments in sion Scale and Beck Depression Inventory were used.
depressive disorders: a Results.– As a result of the analyzes, it was found that according
clinical-qualitative study in a Brazilian to Beck Depression Inventory the depression level of the preg-
specialized adult outpatient service nant women (Mean = 0.67, S = .38) was significantly higher than
L.C. Vieira, R.A. Bastos, E.R. Turato* the depression level of the women who had given birth recently
State University of Campinas, Laboratory of Clinical-Qualitative (Mean = 0.50, S = .46) (p < 0.05).
Research, Campinas, Brazil Conclusions.– There are many sources of anxiety that pregnant
* Corresponding author. women may worry about, such as giving birth to a healthy
child, health of the baby, physiological changes in the body, and
Background and aims.– Psychosocial aspects and life experiences hormonal disorders. In the postpartum period the level of depres-
related to the treatment of depression are important to take into sion decreases because the effect level of these anxiety sources
account by psychiatry team, mainly in case of refractoriness. Resis- decreases.
tant treatment depression is considered by poor response to two Disclosure of interest.– The authors have not supplied a conflict of
antidepressants in dosage and adequate duration. Beliefs, disease interest statement.
representations, or the doctor-patient relationship, are important
aspects that go beyond pharmacologic treatment.
To explore emotional meanings attributed by patients with resis- E-PV0279
tant depression to medication in follow up at the outpatient service Time resolved tryptophan
in General Hospital, at the State University of Campinas, South east- fluorescence as a new approach for
ern Brazil.
Methods.– A clinical-qualitative study using semi-directed inter-
investigation of serum albumin
views with open-ended questions, in-depth. Eight patients disturbances in melancholic
participated of the investigation in a sample closed by information depression
saturation. The interviews were audio recorded, fully transcribed M. Uzbekov1* , T. Syrejshchikova2 , N. Smolina1 , E.
and categorized by Qualitative Content Analysis. The results were Syromyatnikova2 , V. Brilliantova1 , G. Dobretsov3
1 Moscow Research Institute of Psychiatry, Brain Pathology, Moscow,
peer-reviewed in several meetings in the Laboratory of Clinical-
Qualitative Research. Russia; 2 Lebedev Physical Institute, High Energy, Moscow, Russia; 3
Results.– Emerging categories: (1) Perception of refractoriness in Research and Clinical Center of Physic-Chemical Medicine, medical
the understanding of the illness symptoms permanence; (2) refrac- biophysics, Moscow, Russia
tory depression from a profound melancholy perspective of life; (3)
Personal impotence in the perception of the refractoriness com-
plexity phenomenon; (4) Good treatment adherence face to a fear Background and aims.– Psychiatry.
on relapse. Objectives.– Fluorescence of amino acid Tryptophan-214 residues
Conclusions.– Meanings attributed by patients to refractory depres- (Trp-214-R) as inner probe of albumin molecules can give infor-
sion come from the persistence of symptoms due to the continued mation about protein conformational changes. In human serum
use of the medication, appearing to be ‘not taking’. Despite the com- albumin excitation wavelength at 295–305 nm is mainly absorbed
plete remission, there are reports of the symbolic of adhering to by Trp-214-R that gives possibility of selective observation of state
care, threatened by fear of worsening without the remedy. This of albumin molecule.
context generates anguish, especially by the fears associated with Aim.– Investigate of kinetics of tryptophan fluorescence decay in
existential and poorly elaborated life experiences. serum albumin of patients with melancholic depression (MD) using
Disclosure of interest.– The authors have not supplied a conflict of subnanosecond fluorescent spectroscopy.
interest statement. Material and Methods.– There were investigated 14 patients with
MD and 14 healthy volunteers. Patient’s state was defined as a
depressive episode in frame of bipolar depressive disorder (type
E-PV0278 2) (F32) and in structure of recurrent depressive disorder (F33).
Fluorescence decay of serum albumin Trp-214-R was measured in
Comparison of pregnancy and
subnanosecond range using laser device (LED, Pico-Quant). Excita-
postpartum periods in terms of tion wavelength - 290 ± 10 nm; samples were excited by laser flash
depression level (7 × 10−10 sec).
M. Uysal1 , Ş. Karayağız1 , Ö. Bektaş1 Results.– Results. The form of decay kinetics was represented as a
Nuh Naci Yazgan University, Psychology, Kayseri, Turkey sum of three exponentials, described by three decay times ␶i (in 6.5,
2.8 and 1 ns region) and three amplitudes Ai. There were received
significant differences for amplitudes A1 and A3 (p < 0.01) and rela-
Background and aims.– Pregnancy is the period in which women
tionship of A1/A3 и A1/A2 (p = 0.01) between MD and control.
have many biological and psychosocial changes. It also includes
Conclusions.– Conclusion. It was shown the first time in literature
risk factors for depression and anxiety. Pregnancy depression is a
that conformational changes of albumin in mental disorders can
common mental disorder that affects both the mother and the child.
be detected by Trp-214-R fluorescence. Fluorescence of Trp-214-R
Pregnancy depression is also important because of the potential for
can serve as potential biomarker of albumin conformation distur-
suicide attempt and increases postpartum depression risk.
bances.
In this study, it was aimed to compare the depression levels of
women during pregnancy and the level of depression of women
interest statement.
who had recently delivered.
E-PV0280 (mean = 86.1%). The percentage of patients that would have been
Perspectives of depression and excluded was significantly higher in the studies published in 2010
comorbid psychiatric disorders in through 2014 compared to the studies published from 1995 to 2009
(91.4% vs. 83.8%, t(156) = 3.74, p < .001).
South East Asian region Conclusions.– Only a minority of depressed patients seen in clinical
A. Vaithiyam1* , R. Vimala2
1
practice are likely to be eligible for most AETs. The generalizability
Prof Dr, Psychiatry, Madurai, India; 2 Ram Psychiatry Hospital,
of AETs has decreased over time. It is unclear how generalizable the
Psychology, Madurai, India
results of AETs are to patients treated in real world clinical practice.
Background and aims.– Psychiatric disorders account for an enor- interest statement.
mous global burden of disease that is largely underestimated and
under appreciated. In a given year, about 30% of the population
worldwide is affected by a mental disorder and over two thirds of E-Poster Viewing - 7–9 April: E-mental Health
those affected do not receive the care they need. About 14% of the
global disease burden is attributed to neuropsychiatric disorders,
mostly depression, alcohol-substance abuse and psychoses.
Methods.– Methodology is mainly by the clinical resources taken E-PV0282
from various organisation and through peer group (hospital based) Massive online multiplayer games,
survey. fantasy as a psychotherapeutic tool
Results.– Appropriate statistical methods were used for the above J.A. Caicedo Blanco
study. The burden of mental disorders in developing countries is Universidad el Bosque, Psiquiatria, Bogota, Colombia
compounded by high rates of stigma and discrimination, which are * Corresponding author.
major obstacles in the provision and utilisation of mental health

services. The consequences of mental health inequalities include Background and aims.– Massive online multiplayer games have a
continued unnecessary suffering and premature deaths, increased large number of subscribers who are mostly teenagers, the online
stigma and marginalisation, lack of investment in mental health player community is perceived by the general population as well
workforce and infrastructure, and limited or lack of treatment for as by a large part of the medical population as prone to mental
people suffering from these conditions. pathologies, this paper seeks to review the perception of the psy-
Conclusions.– In India there is a paucity of psychiatrist. The statis- chiatric community regarding massive online multiplayer games,
tics of the National Institute of Mental Health India figures are as well as information regarding the prevalence of mental illness in
worrisome and lack of resources in the main drawback of national players of these games and describe the concept of fantasy as a ther-
mental health implementation in Indian region. The projected bur- apeutic tool proposing the possibility of establishing a therapeutic
den of mental health disorders is expected to reach 15% by the year space within this virtual context.
2020, where common mental disorders (depression, anxiety, and Methods.– Narrative review of literature.
substance-related disorders including alcohol) will disable more Results.– The review of the literature showed that in different stud-
people than complications arising from AIDS, heart disease, traffic ies the general population and the medical population associates
accidents and wars combined. online players with people with poor social skills, however the
Disclosure of interest.– The authors have not supplied a conflict of prevalence studies do not find a greater susceptibility to mental
interest statement. pathologies in this population.
The literature describes successful psychotherapeutic processes in
virtual contexts.
E-PV0281 Conclusions.–
Have treatment studies of depression - Most of the studies that address online games address the issue
from Ludophaty.
become even less generalizable?
- The online player is perceived as a person with poor social skills,
M. Zimmerman1* , C. Balling2 , I. Chelminski2 , K. Dalrymple2
1 which is not corroborated by the literature.
Brown University, Psychiatry and Human Behavior, Providence,
- Fantasy has been described by multiple authors in the psychoan-
USA; 2 Rhode Island Hospital, Psychiatry, Providence, USA
* Corresponding author. alytic and psychodynamic literature as a projective tool.
- There is a precedent of effective online psychotherapeutic pro-
Background and aims.– Antidepressants are amongst the most cesses, such as online behavioral cognitive therapy.
frequently prescribed medications. More than a decade ago Disclosure of interest.– The authors have not supplied a conflict of
our clinical research group applied a prototypic set of inclu- interest statement.
sion/exclusion criteria used in an antidepressant efficacy trial (AET)
to patients presenting for treatment in our outpatient practice
and found that most patients would not qualify for the trial. In E-PV0283
the present report from the Rhode Island Methods to Improve Development and usability test in a
Diagnostic Assessment and Services (MIDAS) project we apply primary care centre of an app for the
the psychiatric inclusion/exclusion criteria used in 158 placebo- needle exchange programs
controlled studies to a large sample of depressed patients who F. Calvo1* , X. Carbonell2 , C. Mundet3 , C. Giralt4 , S. Castillejos5 , L.
presented for outpatient treatment to determine the range and Cabanillas6 , S. Saura6
extent of the representativeness of samples treated in AETs and 1 Institut d’Assistència Sanitària, Health, Girona, Spain; 2 FPCEE
whether this has changed over time. Blanquerna, Universitat Ramon Llull, Barcelona, Spain; 3 Servei de
Methods.– We applied the inclusion and exclusion criteria used in Promoció de la Salut a Girona, Agència de Salut pública de Catalunya,
158 AETs to 1,271patients presenting to an outpatient practice who Girona, Spain; 4 CAS Girona, Institut d’Assistència Sanitària, Girona,
received a principal diagnosis of major depressive disorder. The Spain; 5 FPE, Universitat de Girona, Girona, Spain; 6 CAP
patients underwent a thorough diagnostic evaluation. Montilivi-Vila Roja, Institut Català de la Salut, Girona, Spain
Results.– Across all 158 studies, the percentage of patients * Corresponding author.
that would have been excluded ranged from 44.4% to 99.8%
Background and aims.– Usability tests are essentials before to offer E-PV0285
to general population health apps. Needle Exchange Programs Association of life orientation index
needs new interventions to improve its results. The aim of this
and parameters of emotional
study is to analyse the process of development and test of usability
of a mobile device application designed to complement the Needle
intelligence in university students: a
Exchange Program. data mining approach
Methods.– A transversal and observational design was conducted E. Gkintoni1* , C. Halkiopoulos2 , H. Antonopoulou2 , M. Georgiadi3 ,
in a Primary Care Centre and in a street drug-consumption zone, S. Plexousakis3
1 Technological Institute of Western Greece, Entrepreneurship &
both in the city of Girona.
Main measures: Sex, age and personal use of ICT was compared Digital Innovation Laboratory, Patras, Greece; 2 Technological
with the acceptance of the app. Central tendency and dispersion Institute of Western Greece, Entrepreneurship & Digital Innovation
measures, U-Mann Whitney test and cross tables was used for the Laboratory, Patras, Greece; 3 University of Crete, Psychology,
statistical analysis. Rethymno- Crete, Greece
A literature review of mHealth and drug dependence was devel-
oped and a usability test for each target group was performed.
Background and aims.– Life Orientation is aimed at developing and
Results.– Participants were 13 members of a multidisciplinary med-
engaging young adults in personal, psychological, neurocognitive,
ical team and 9 people who inject drugs. No differences were found
motor, physical, moral, spiritual, cultural and socio-economic areas,
between the analysed variables and the opinion of the app. Partic-
so that they can achieve their full potential in order to success in
ipants proposed improvements about the prototype that will be
future life. The aim of the present study is to assess individual differ-
apply in the definitive interface.
ences in generalized optimism versus pessimism in the index of life
Conclusions.– Professionals and potential users share similar opin-
orientation and parameters of emotional intelligence in a sample
ion about the app and its uses. The participation of professionals
of university students through application of data mining methods.
and patients in usability test of mobile applications facilitates the
Methods.– The sample comprised 300 university students, males
detection of particular needs.
and females, aged 18-30 years and assessed using self-administered
questionnaires. The 10-item version of Life Orientation Test Revised
interest statement.
(LOT-10), and the Trait Emotional Intelligence Questionnaire
(TEIQue). The methodology adopted, in first phase consists of elec-
E-PV0284 tronic questionnaires, which were created and posted through
the website http://www.cicos.gr. Subsequently data were collected
Childhood abuse and mental health and preprocessed from the questionnaires and then introduced into
indicators among gay and bisexual the R (Programming Language and Machine Learning Platform) for
adults analysis and extraction of useful knowledge.
A. Chaabouni1* , R. Sellami1 , S. Elleuch1 , M. Moalla1 , I. Baati1 , F. Results.– More specifically, through using classification algorithms
Msakni2 , A. Zahaf2 , I. Feki1 , J. Masmoudi1 (C4.5) there was a production of prospectively decision trees. Fur-
1 Hedi Chaker Hospital, Psychiatric Department ‘A’, Sfax, Tunisia; 2
thermore, clustering technique (K-Means algorithm), was applied
Tunisian Association Against Sexually Transmitted Diseases and AIDS and the parameters of the algorithm were set, depending on the
ATL, Department, Sfax, Tunisia application cases and the respondents were classified into clusters
based on the items of the two scales.
Conclusions.– The results indicate among others, that the use of Data
Background and aims.– Epidemiological studies find that gay and Mining methods is an important tool to export and receive the
bisexual people had more experience of childhood abuse com- conclusions and decisions especially in the field of psychological
pared to heterosexuals. However, few studies have interested in the assessment and in mental health.
mental health impact of these experiences. In our study, we are pro- Disclosure of interest.– The authors have not supplied a conflict of
posed to examine the relationships between anxiety, depression, interest statement.
self esteem and childhood abuse among gay and bisexual adults
compared to heterosexual adults.
Methods.– This was a descriptive and analytical cross-sectional E-PV0286
study of 12 gay and bisexual adults who were recruited in a Tunisian
Non-physical violence against
association against sexually transmitted Diseases and AIDS (ATL) in
Sfax-Tunisia during four months of 2018. healthcare professionals
Results.– The population of the study was male. The mean age was Z. Hakim* , K. nada, F. amen, S. imen, J.H. kaouthar, M. mohamed
23.53 years. All were single and had an average socio-economic larbi, H. Mounira
level. In our sample, 61.5% were university level and had a regu- Hedi Chaker Hospital, occupational medicine, Sfax, Tunisia
lar work. The half of our sample were homosexual, the other were
bisexual. Depression was noted in 30.8% of the participants, anxiety Background and aims.– Work-related violence is an important prob-
in 38.5% and childhood abuse in 29.9% of the cases. forty six of sub- lem worldwide, and healthcare professionals are at increased risk.
jects had a low self esteem. The average overall CTQ score was 49.61. Particularly, non-physical violence at work is one of the major con-
There was no significant difference in the two groups in terms of cerns in health care activities.
depression, anxiety and self esteem. We found a significant differ- The aim of this study was to identify the prevalence of non-physical
ence between the two groups in the CTQ questionnaire for all forms violence in two public hospitals in Sfax in the past 12 months and
of maltreatment except for emotional abuse and physical abuse. to assess its consequences.
Anxiety was associated with childhood abuse (P = 0,022). There was Methods.– We have proceeded to a cross-sectional study among
no significant relationship between abuse and depression. professionals from two hospitals in Sfax, Tunisia, using a self-
Conclusions.– Findings suggest that sexual abuse may be an impor- administered questionnaire. We then performed descriptive
tant factor on sexual orientation and promotes the appearance of analyses on the collected data.
anxiety. Results.– Respondents included 110 workers. The prevalence of
Disclosure of interest.– The authors have not supplied a conflict of violence was 54.5%. Verbal abuse was more common (50.9%).
interest statement. Healthcare givers were exposed to verbal violence in its multiple
subtypes: rudeness and impolicy (59.3%), insults (56.6%), verbal Background and aims.– The aim of the project is to create a group
threats (54.7%) and shouting (43.4%). The perpetrators of non- of services, which, with their interconnection and implementation
physical violence were patient’s families in 83.9%, the patient in into existing or emerging systems and mobile devices support, will
42.8% then the visitors in 17.8%. Verbal abuse affected health be used to develop eMental health care in the Czech Republic.
professionals more than 5 times in 21.42% of cases. Immediate con- The main innovation and contribution is the usage of potential of
sequences of violence were reported by victims as nervousness the micro-services architecture from the world of informatics into
(64.28%). About third of the respondents (32.14%) have tried to preventive and interventional medicine with automatic setting of
defense themselves, and 25% have reported the incident to their all services according to GDPR principles. By creating the individual
superior. Later, the majority of victims (89.2%) didn’t express any services necessary for each new eMental health care application, we
reaction, four victims wrote a report to their superior and only two build the foundation stone for implementing specific implemen-
workers filed a complaint. tations such as intervention and education programs, screening
Conclusions.– This study suggested that workplace violence occurs programs and more.
commonly in Tunisian healthcare settings. Effective intervention Methods.– Our current practice with developed services and their
strategies targeting workplace violence should be formulated in applications for the end user is currently in the scope of developing
terms of major risk factors. basic tools and implementation in the Mindfulness intervention
Disclosure of interest.– The authors have not supplied a conflict of program.
interest statement. To our program “The eight-week on-line program to promote men-
tal and physical health based on mindfulness for students and
employees” more than 800 people have signed up, which exceeds
E-PV0287 the share of all published similar programs (Fish, Brimson, & Lynch,
Virtual reality in psychiatry: is it not 2016).
too early to announce a shift in the Results.– The program was fully automated using Slack. The Slack
application is more compatible with our system and gives us space
paradigm?
to get statistics about program efficiency and users adherence.
A. Karlińska* , S. Mandes
Conclusions.– One part of the system presentation will be about
University of Warsaw, Institute of Sociology, Warsaw, Poland
* Corresponding author. analysed data from the currently running Mindfulness program and
adherence.
Background and aims.– First attempts to use virtual reality (VR) for This project was supported by VaV program from MUNI, 2018.
diagnostic and therapeutic purposes in mental health (MH) dates Disclosure of interest.– The authors have not supplied a conflict of
back to 1990s. Recent technical developments made VR feasible interest statement.
and raised expectations about its usefulness for clinical practice.
Our aim is to provide a methodological critique of research on VR
technology conducted by MH professionals, especially concerning E-PV0289
the issue of ecological validity. Suicide intervention assisted by
Methods.– The study will be based on a systematic review of the messages (SIAM): a caregiver
literature performed in compliance with the Preferred Report- acceptability study
ing Items for Systematic Reviews and Meta-Analyses statement. T. Lagathu* , S. Berrouiguet, C. Lemey, C. Mesmeur, M. Walter
Two researchers will independently search MEDLINE, PsycINFO and Chru Brest, Hopital de Bohars, Brest, France
EMBASE from the years 1990–2018 to identify studies evaluating * Corresponding author.
the use of VR for diagnostic or therapeutic purposes in MH.
Results.– Few papers indicate what makes virtual environment an Background and aims.– Preventing suicide is a public health-care
effective diagnostic and therapeutic tool. MH professionals very matter of paramount importance. Among the preventative strate-
rarely address the issue of ecological validity of their research and gies, surveillance devices have shown interesting results. They are
limit themselves to stating that the VR therapy can result in sig- based on the hypothesis that maintaining a link with a suicidal
nificant real-world outcomes. The results of previous studies do patient helps to reduce the risk of recidivism.
not allow for such generalizations due to small sample sizes and The main purpose of this pluricentric prospective study is to evalu-
methodological limitations. ate the caregivers’ acceptability of using an e-santé web application
Conclusions.– MH professionals tend to view VR as a harbinger to maintain a link with the suicidal patients by sending them SMS
of a shift in the paradigm of diagnosing and treating psychiatric (SIAM study (Suicide Intervention Assisted by Messages)).
disorders. However, there is still large discrepancy between the Methods.– A sample of 98 caregivers was thus recruited (33 nurses,
expected and proved usefulness of VR. Further research may also 41 doctors, and 24 residents) from March 2018 to May 2018. They
bring ambiguous results unless the conceptual apparatus becomes were first contacted by email and asked to complete by themselves
clearly defined, including uniform methodological approach and an anonymous questionnaire. Among other questions, the ques-
measures of outcome. tion of the acceptability was evaluated through the following one:
Disclosure of interest.– The authors have not supplied a conflict of « Would you recommend this device to your colleagues? » The cal-
interest statement. culation was made by the Net Promoter Score (NPS). This question
is usually used as an indicator of accuracy.
Results.– They show the global adherence of the caregivers (NPS:
E-PV0288 1.1). However, with details of the different occupations, it appeared
Efficient use of micro-services that the results of the psychiatrists were negative (NPS -244). The
architecture for emental health care nurses and the residents have positive NPS (3.03 and 4.17) although
there is a high level of caregivers who also gave indeterminate
development in the Czech Republic
answers (54% and 42% respectively).
T. Knejzlikova1* , M. Svetlak1 , P. Linhartova2
1 Conclusions.– Subsequently, it will be necessary to determinate the
Faculty of medicine- Masaryk University Brno- Czech Republic,
reasons of the caregivers’ uncertainty to set up actions to encourage
Department of psychology and psychosomatic, Brno, Czech Republic;
2 Faculty of medicine- Masaryk University Brno- Czech Republic, them adhere to the protocol.
Department of psychiatry, Brno, Czech Republic
E-PV0290 data about its effectiveness in these communities and whether or

An exploratory analysis of the uses not the transgender community was represented.
and representations shaping French Results.– Telemental health is used widely in many populations but
there is little published data on its use and effectiveness in the
schizophrenia groups on facebook transgender and gender diverse populations in Canada.
D. Lampropoulos* , A. Thémis
Conclusions.– Telemental health’s use and effectiveness has been
Aix-Marseille University, Laboratoire de Psychologie Sociale EA849,
demonstrated in various rural, remote and minority populations
Aix-en-Provence, France
throughout Canada. There is little published data on its use in bridg-
ing the gap in the lack of access to transgender individuals in remote
Background and aims.– Health-related groups on Facebook are and rural areas. There is a need for more research in the use in the
being increasingly used for peer support and information exchange. transgender population.
However, research on their functions and the representations Disclosure of interest.– The authors have not supplied a conflict of
that constitute them is still quite limited and specifically, there interest statement.
is no study on schizophrenia groups on Facebook. The current
study, drawing from the Social Representations approach, aimed to
E-PV0292
explore the uses and functions of French-speaking Facebook groups
related to schizophrenia, as well as the representations that underly Impact of cellular reminder on follow
them. up patients suffering from psychosis:
Methods.– Two main schizophrenia groups have been identified randomized controlled trial
through Facebook’s own search function, the first being adminis- N. Mehmood1* , U. Talib2
tered by professionals, the second by peers. After data extraction, 1 Karwan E Hayat Institute of Mental Health Care, Research &
initial posts were submitted to an inductive thematic analysis in Development, Karachi, Pakistan; 2 Karwan E Hayat institute of
order to identify the purpose of communication and both posts and Mental Health care, Medical, Karachi, Pakistan
comments were submitted to a content analysis concerning their * Corresponding author.
representational content.
Results.– Thematic analysis indicated that while the main function Background and aims.– Many methods to remind patients about
of the first group was to answer to members’ demand for support their appointments have been studied, including personal phone
and knowledge, through experience sharing and advice seeking, calls, automated phone calls and mailed letters. However, Mobile
the second focused on the offer of support and knowledge, though phones using the short message service (SMS) are now common-
advice giving and information sharing. The first group explicitly place in both developed and developing countries Mobile phone
promotes evidence-based practices and is pro-psychiatry, while the messages have the advantage of being convenient, inexpensive and
second group is encompassed by tensions concerning traditional able to reach to the intended person immediately.
structures, such as psychiatry that is often seen as repressing, family Objective.– To evaluate the impact of tailored cell phone text mes-
that is often seen as a cause of suffering and medication that is sages to improve the follow up patients suffering from psychosis.
presented as harmful. Methods.– A randomized controlled study with a Two-armed trial
Conclusions.– Research on health-related Facebook groups allows conducted in Karwan e hayat, Karachi.
exploration of representational contents and tensions that shape The participants was recruited from out patients setting of Kar-
one’s relation to the disorder and citizenship. wan e Hayat. A total of 248 participants was randomly divide into
Disclosure of interest.– The authors have not supplied a conflict of two groups; SMS group and control group. The participants were
interest statement. adult patients aged 18–65 years and taking antipsychotic medica-
tion, who have a mobile phone, are able to use the Urdu language.
The SMS group was receiving automatic system messages after they
E-PV0291 recruited in study.
E-health: serving rural, remote and Results.– There were no significant differences between two groups
at baseline. At three months follow up attendance rate for the SMS
institutional transgender populations
group (48%) was significant higher than for the control group (22%)
- a review in initial 100 participants based on a 2-sample test of proportion
M. Marshall1* , G. Knudson2 , S. Leibel3 (P = 0.048).
1 University of Alberta, Psychiatry, Edmonton, Canada; 2 University of Conclusions.– This study demonstrated that text messaging inter-
British Columbia, Psychiatry, Victoria, Canada; 3 University of ventions are feasible and cost effective interventions to improve
Calgary, Social Work, Edmonton, Canada the follow up attendance rate in outpatient setting, especially for
the people with psychosis.
Background and aims.– Persons in Canada who are transgender and Disclosure of interest.– The authors have not supplied a conflict of
gender diverse face barriers to accessing good, compassionate and interest statement.
timely physical and mental health care. This is more so for indi-
viduals who live in rural or remote Canadian communities and in
E-PV0293
institutional settings. It has been shown that transgender individ-
uals have higher rates of mental health morbidity than the general E - sapiens sapiens the next
population. This is coupled with the stigma and isolation of remote evolutionary step?
and rural communities. G. Hesles Sanchez1 , L. Moron Nozaleda2*
1 Universidad Miguel de Cervantes. Universidad Villanueva., Social
Telemental health has been successful in providing psychiatric
healthcare to remote communities throughout Canada. This paper sciences, Madrid, Spain; 2 Pofessor Dr, Neuroscience, Madrid, Spain
examines whether telemental health has also been used to remove
the barriers to care for the transgender and gender diverse popu-
lation. Background and aims.– We live with cyborgs, with humans repaired
Methods.– The authors reviewed published literature on the use of or restored thanks to pacemakers, automatic defibrillators, audi-
e-health (telemental health, tele psychiatry, and others) to remote, tory transducers (cloquear implants), organs or bionic limbs,
rural, institutional and minority communities in Canada, to find antennas to hear the colors (eyeborg), and there is great hope in
the graphene retinas to recover vision.
After the repair or restoration, it usually comes the improvement. Disclosure of interest.– The authors have not supplied a conflict of
As in the intellectual field we achieved hundreds of years ago - interest statement.
with pencils and papers- to increase our memory and collective
memory: what can we achieve with AI applied exclusively to the
neurophysiology of human being? E-PV0295
Our intention is to demonstrate that AI has no path in neurophysiol- Present-day scope for psychological
ogy without natural intelligence. While the second is optimal to get internet counseling in mental health
answers, the first is vital to raise the questions that really allow us to
problems
advance in this man-machine symbiosis. Our study raises the need
E. Nikolaev* , V. Ivanov
to generate the right questions, that is, to formulate a projection of
Ulianov Chuvash State University, Social and Clinical Psychology
the possible applications of AI to neurophysiology.
Department, Cheboksary, Russia
Methods.– General research. Specialized publicatios, journals, web- * Corresponding author.
sites.
Results.– The objective is to add the best of human abilities, intu- Background and aims.– Information and communication technolo-
ition, creativity, empathy, with computational skills, which we will gies have gradually entered nearly all spheres of life bringing in
call e-sapiens. each something novel. Internet-based psychological counseling
Conclusions.– Natural intelligence has allowed - for good, for evil in for mental health problems has also joined the cause. Originally,
some cases - to end natural selection. And in full artificial selection professional psychological help had been available only face-to-
we face the improved human, with an increased intelligence that face during a patient’s personal visit to a psychologist. Steady
thanks to implanted brain-machine interfaces will connect people development of the Internet technologies opened new ways of psy-
to computers that will allow the former to process more data (big chological services. More people with mental disorders seek help
data) at a higher speed, discarding failed roads before traveling over on the Internet, which is more advantageous.
them, and also, of course, detect, diagnose and eradicate mental Methods.– Based on the analysis of both the authors’ personal
illness. practical experience and a wide range of offers of psychological
Disclosure of interest.– The authors have not supplied a conflict of counseling available today on the Internet, below, we describe the
interest statement. potentials and restrictions of online psychological counseling.
Results.– The advantages of online psychological counseling include
absence of boundaries, saving a patient’s time and a psycholo-
E-PV0294 gist’s costs, a patient’s possibility to choose a specialist, possibility
Teleconsultation in major depressive of urgent assistance, location of a patient in their personal com-
disorder fortable zone, availability of assistance for disabled people. Online
J. Mota-Pereira1* , D. Fonte1 , R.J. Teixeira2 , S. Carvalho3 counseling can be carried out in the form of text messages via e-
1 Clínica Médico-Psiquiátrica da Ordem, Psychiatry, Porto, Portugal; 2 mail, forums, chatting, SMS, or audio or video counseling via Skype,
Clínica Médico-Psiquiátrica da Ordem, Psychology, Porto, Portugal; 3 Webinar Rooms, Viber, WhatsApp, etc. It can address one individ-
Hospital de Magalhães Lemos, Porto Psychiatric Department, Porto, ual or a group in a real-time or delayed-response mode. The main
Portugal restrictions are ethical and judicial, psychological.
* Corresponding author. Conclusions.– The described potentials open good prospects for the
development of both mental health services and psychologists. Psy-
Background and aims.– chological Internet counseling may be used as a separate measure
Introduction.– Due to the severity of symptoms associated with or may be combined with face-to-face practices of psychological
Major Depressive Disorder (MDD), some patients have difficulties interventions in case of mental health problems.
in attending the appointments with their psychiatrist, such as the Disclosure of interest.– The authors have not supplied a conflict of
distance to the clinic, financial difficulties or agoraphobia. Skype interest statement.
removes all these barriers, and could promote not only more reg-
ular medical appointments but also, and not less important, allow
for patients with agoraphobia to have appointments, since some E-PV0296
of these patients refuse to leave home. The understanding of the Mental health mobile apps: a new
impact of psychiatry consultations by videoconference platforms
therapeutic tool
on clinical results and wellbeing of the patients is important for
S. Petrykiv1* , L. de Jonge2 , M. Arts3
the adaptation and modification of the psychiatric clinical practice. 1 Maastricht University Medical Center, Department of Clinical
Objectives.– The aim of this work was to assess the efficacy of Skype
Pharmacy and Pharmacology, Maastricht, The Netherlands; 2
in patients with treatment-resistant major depressive disorder (TR-
Leonardo Scientific Research Institute, Department of
MDD) with or without other psychiatric co-morbidities, such as
Neuropsychiatry, Groningen, The Netherlands; 3 GGZ WNB Mental
agoraphobia or generalized anxiety disorder.
Health Care, Department of Old Age Psychiatry and Neuropsychiatry,
Methods.– One-hundred and seventy patients were divided into
Halsteren, The Netherlands
two groups, one office consultation group (n = 85) and a Skype * Corresponding author.
consultation group (n = 85). All patients maintained their usual
pharmacotherapy. All participants were evaluated at baseline, 6 Background and aims.–
and 12 months for depressive symptoms (HAMD17), disease sever- Background.– Mental health mobile apps represent a new alterna-
ity (CGI-S) and function (GAF). tive to enlarge the quality and availability of psychiatric treatment.
Results.– There were no differences in these three parameters Although these types of treatment seem to be cost-effective, it’s
among the two groups, over time. However, the percentage of efficacy remains questioned. In this study, we provide an overview
patients in remission after 12 months was higher in the Skype of apps that are applicable for mental health.
group. Aims.– To present the efficacy of evidence-based mobile apps for
Conclusions.– Psychiatric online consultations are more effective the treatment of mood disorders, anxiety, and psychotic disorders.
than office (face-to-face) consultations regarding remission of Methods.– An English language literature search was conducted
patients with major depressive disorder, allowing them to over- using Pubmed and EMBASE searching for reporting the efficacy of
come the barriers caused by the distance or some co-morbidities. mental health software applications.
Results.– Preliminary evidence indicates that mental health mobile a clear pathomorphosis - typical anorectic and bulimic symp-
apps show promise in improving medication adherence, reduce toms that formed already in childhood, Identification, classification,
anxiety symptoms, decreasing psychotic and depressive symp- study of pathogenesis and dynamics of dysmorphophobia in child-
toms. hood and adolescence in patients with AN and BN were the aims of
Conclusions.– Mobile apps for the treatment of psychiatric disorders the study.
have expanded rapidly and have a considerable potential. However, Methods.– 65 patients with AN and BN aged from 12 to 18
the heterogeneity and often poor quality still hinder any explicit years were examined. The duration of the disease is from 3
conclusions. months to 7 years. Methods of research: anamnesis, clinical-
Disclosure of interest.– The authors have not supplied a conflict of psychopathological, anthropometric, catamnestic, psychometric
interest statement. scales - Questionnaire image of one’s own body, the Scale of satis-
faction with one’s body.
Results.– Dissatisfaction with their body in 43% was severe, 25%
moderate, 32% light. 42% were not satisfied with the head, 54% not
E-Poster Viewing - 7–9 April: Eating Disorders satisfied with the body and 57% with the lower part of the body.
In 40% of patients was observed polydysmorphophobia. In 30% of
patients dysmorphophobia occurred in childhood, 70% - in early
E-PV0297 adolescence.
Trauma and eating disorders: are they Conclusions.– In most patients with AN and BN, dysmorphophobia
occurred at an early age, was often polythematic, determined the
related?
quality of life, influenced the course, outcomes and prognosis of the
I. Caldas* , I. Pinto, C. Pereira
disease.
Centro Hospitalar Psiquiátrico de Lisboa, General Psychiatry, Lisbon,
The publication was prepared with the support of the “RUDN Uni-
Portugal
* Corresponding author. versity Program 5-100”.
Background and aims.– Throughout life, about 6,1% of women meet interest statement.
the criteria for the diagnosis of eating disorders (ED) [1]. Several
factors such as personality, biology and social environment have
been suggested as causal factors [2]. Also, PTSD and trauma are E-PV0299
recognized as common comorbidities in patients with ED [3]. Representatiom of anorexia nervosa
Objective.– Understand the impact that trauma could have in the in caregivers, working with children
development of eating disorders. and adolescents in a mental
Methods.– The author conducted a non-systematic review of the
literature by searching the Pubmed database using the keywords
healthcare centre
D. Dovbysh1,2* , E. Podurova1
Eating disorders; Trauma; PTSD. 1 Scientific-Practical Children’s and Adolescents Mental Health Center
Results.– The risk of food addiction (FA) increases by 90% when
n.a. G. Sukhareva- Moscow Department of Health Care- Moscow-
associated to severe physical and sexual abuse events. The severity
Russia, Psychiatry, Moscow, Russia; 2 Federal State Autonomous
of FA is strongly associated with binge eating (BE)[4]. People who
Educational Institution of Higher Education I.M. Sechenov First
purge or binge, as in Bulimia Nervosa, display a higher prevalence
Moscow State Medical University of the Ministry of Health of the
of rape history with PTSD (10.4%), compared to people with a his-
Russian Federation Sechenov University, Faculty of Higher Nursing
tory of rape without PTSD (2.0%) and subjects with no history of
Training- Psychology and Social Work, Moscow, Russia
rape whatsoever [5]. * Corresponding author.
Conclusions.– Traumatic experiences during childhood have impor-
tant consequences for psychopathology in general [6]. People who Background and aims.– Despite the fact that anorexia nervosa offi-
get higher scores in trauma scales show higher body dissatisfaction cially belongs to DSM since the first edition (1952) and has long
than those who score low on the same scales [7] and women with been considered as a mental disorder, in modern society it is often
sexual trauma history are significantly more likely to exhibit psy- not even nowadays considered to be a serious, life threatening dis-
chopathology than control group subjects, including higher rates ease.
of comorbidities such as PTSD and EDs [5]. It is important to assess Assess the idea about anorexia nervosa after undergoing an educa-
previous traumatic experiences in the early stages of treatment in tional destigmatizing program.
patients with purging behaviors. Methods.– A training seminar about eating disorders in advanced
Disclosure of interest.– The authors have not supplied a conflict of training course; structured interview, built around the analysis of
interest statement. cases of anorexia nervosa in adult and adolescent patients.
Results.– 97% of participants consider anorexia nervosa a mental
disorder, but in only 73% of the cases psychiatrist was recommend.
E-PV0298 42% of the participants on the direct question of the parents’ fault in
Variants of dysmorphophobic the formation of anorexia nervosa answer «yes», 33% would blame
disorders in children and adolescents the person for illness. 80% of the respondents would dissuade rel-
with anorexia nervosa and bulimia atives from getting married with an adult with symptoms of for
work in the absence of doubt in his professional skills. There are
nervosa
no statistically significant differences between groups of partici-
A. Bryukhin, I. Belokrylov, T. Lineva, I. Danilin* , E. Okonishnikova,
pants with different experience in psychiatry. A separate result of
G. Kirsanova
the work is the selection of the most popular symptoms of anorexia
Peoples’ Friendship University of Russia RUDN University,
in terms of employees.
Department of psychiatry and medical psychology, Moscow, Russia
* Corresponding author. Conclusions.– Lack of professional knowledge about the specific
features of eating disorders among professionals working in psy-
Background and aims.– Previously, the occurrence of anorexia ner- chiatry potentially reduces quality of care and contributes to the
vosa (AN) and bulimia nervosa (BN) in childhood and adolescence formation of distorted ideas about anorexia nervosa in patients and
was considered as casuistry. In recent decades, we have observed in society.
Disclosure of interest.– The authors have not supplied a conflict of AN and its relationship to organ damage and metabolic abnormal-
interest statement. ities by measuring autonomic function in individuals with AN. It is
hypothesised that the AN group will demonstrate atypical sympa-
thetic nervous system compared to the control group, and this will
E-PV0300 be related to increased cardio-metabolic disturbances.
Eating disorders and alexithymia in Methods.– Participants will include 30 individuals with AN, 30
college students recovered from AN and 30 matched controls who will be assessed
F. Guermazi* , I. Lajmi, I. Baati, R. Sellami, M. Moalla, I. Feki, J. on measures of autonomic nervous system function including;
Masmoudi nerve activity, endothelial function, arterial stiffness and sudomo-
Hedi Chaker University Hospital - Sfax - Tunisia, Psychiatry “A” tor function. Participants will provide blood and urine samples
Department-, Sfax, Tunisia which will undergo lipidomic and metabolomic analysis.
* Corresponding author. Results.– All assessment variables will be compared between the
two AN and the control group with analysis of variance (ANOVAs).
Background and aims.– Researches on troubles of emotional con- Pearson’s and Spearman’s correlations will be used to evaluate the
trol in addictions, such as the eating disorders (ED) have mainly relationships among different variables.
focused their attention on alexithymia concept, defined by Sifneos Conclusions.– It is hypothesised that the AN group will demonstrate
as a deficit in emotion processing. atypical ANS activity compared to the control group, and this will
The aims are to estimate prevalence rate of alexithymia and ED and be related to increased cardiometabolic disturbances. Understand-
to explore the relationships between alexithymia and ED in college ing the underlying mechanisms of organ and metabolic dysfunction
students. associated with AN will allow clinicians to establish effective pre-
Methods.– College students, via Facebook, were recruited online, vention and treatments to prevent long term organ damage in AN.
during the first half of February 2018, to participate in an online Disclosure of interest.– The authors have not supplied a conflict of
survey on ED. interest statement.
We used an anonymous self –questionnaire composed of 57 items
designed to record some sociodemographic and clinical data.
The screening of ED was made thanks to the Test Eating Attitudes E-PV0302
(EAT-26). Patients with eating disorders:
Alexithymia was evaluated by the Toronto Alexithymia Scale, (TAS- outcome inpatient care
20). J. Jerónimo* , J. Rema, T. Cavaco, E. Reis, J. Santos
Results.– The mean age of students was 17 years. In terms of gender Centro Hospitalar Lisboa Norte, Serviço de Psiquiatria e Saúde
distribution, 57.1% of the sample was girls. Body mass index average Mental, Lisboa, Portugal
was 21.21. The frequency of alexithymics was 40.5% with a mean * Corresponding author.
score of 60.02. The frequency of students with potential ED was
33.3% with a mean score of 15.71. This prevalence of ED is higher Background and aims.– Eating disorders (ED) are characterized by
among girls than boys (37.5% vs 27.8%, p = 0.508). The prevalence a persistent disturbance of eating behavior that results in altered
of potential ED in the alexithymics (47.1%) was significantly higher consumption of food and significantly impairs physical health or
than that in the non-alexithymics (24%). The TAS-20 scores were psychosocial functioning.
significantly correlated to the presence of ED (p = 0.026). The EAT- ED classified in DSM-5 are anorexia nervosa (AN), bulimia ner-
26 scores was significantly correlated to the Externally-Oriented vosa (BN), binge eating disorder, pica, rumination disorder,
Thinking subscale of theTAS-20 (p = 0.001). avoidant/restrictive food intake disorder (ARFID), other specified
Conclusions.– Our study emphasizes the relationship between alex- feeding or eating disorder (OSFED) and unspecified feeding or eat-
ithymia and disorder of eating behavior among college students ing disorder (UFED).
showing the difficulty in discriminating between feelings and phys- ED’ treatment is complex and challenging and sometimes hospital-
ical sensations. ization is needed. Criteria for hospitalization in ED are defined and
Disclosure of interest.– The authors have not supplied a conflict of NICE clinical guidelines are among the most frequently used.
interest statement. To present and discuss our units results of the inpatient treatment
program.
Methods.– Review of clinical files of all patients hospitalized at our
E-PV0301 unit from 1 January 2013 to 31 August 2018 followed by statis-
Protocol for investigating the tical analysis of data. Treatment outcome was assessed by body
cardiometabolic profile of individuals mass index (BMI) variation. BMI was determined at baseline and
discharged.
with anorexia nervosa
Results.– Anorexia nervosa was the most frequent diagnosis. A
Z. Jenkins1* , A. Phillipou2 , D. Castle3 , E. Lambert4
1 remarkable high medical and/or psychiatric comorbidity was pre-
St. Vincent’s Hospital, Mental Health, Melbourne, Australia; 2
sented. When looking for compensatory behaviors presented by
Swinburne University of Technology, Centre for Mental Health,
inpatients we notice the major predominance of vomiting, either
Melbourne, Australia; 3 St. Vincent’s Hospital & the University of
isolated, or in association with misuse of laxatives.
Melbourne, Psychiatry, Melbourne, Australia; 4 Swinburne University
Conclusions.– Inpatient treatment for patients with eating disor-
of Technology, Iverson Health Innovation Research Institute,
ders in our unit is considered only for those whose disorder has
Melbourne, Australia
* Corresponding author. not improved with appropriate outpatient treatment, associated
with high or moderate physical risk, or for whom there is a signifi-
Background and aims.– The energy deprivation and malnutrition cant risk of suicide or severe self-harm. So, most inpatients at have
associated with Anorexia Nervosa (AN) places immense pressure disorders of high severity.
on the cardiovascular system, with up to 80% of patients suffer- Disclosure of interest.– The authors have not supplied a conflict of
ing from cardiovascular or metabolic complications, of which the interest statement.
aetiology remains poorly understood. Research suggests that car-
diovascular and metabolic abnormalities are linked to disturbances
in nerve activity called autonomic dysfunction. This research will
specifically investigate sympathetic nervous system aberration in
E-PV0303 but the relationship was not significant with the EAT-26 scores
Anorexia nervosa and mesenteric (p = 0.052).
superior artery syndrome Conclusions.– Conclusion Our study highlighted the psychological
J. Jerónimo* , T. Cavaco, E. Reis, J. Rema, J. Santos distress which could accompany eating disorder and suggest that
Centro Hospitalar Lisboa Norte, Serviço de Psiquiatria e Saúde an earlier focus on self-esteem may be warranted in the treatment
Mental, Lisboa, Portugal of ED.
Background and aims.– The superior mesenteric artery syndrome Disclosure of interest.– The authors have not supplied a conflict of
(SAMS) results from compression of the third portion of the duo- interest statement.
denum, limited posteriorly by the aorta and anteriorly by the
superior mesenteric artery. The simultaneous diagnosis of SAMS
E-PV0305
and anorexia nervosa (AN) is rare, and there are only a few cases in
the literature. How body image relates to eating
The relationship between these pathologies, with common clini- disorders
cal manifestations, is not consensual. Presentation of a literature I. Lajmi* , F. Guermazi, I. Baati, R. Sellami, M. Moalla, I. feki, J.
review of simultaneous diagnosis of SAMS and AN. Masmoudi
Methods.– Bibliographical search in the PubMed database, using as Psychiatry, Department of Psychiatry A- Hedi Chaker University
keywords “anorexia nervosa” and “mesenteric superior artery”. Hospital, Sfax, Tunisia
Results.– Rapid weight loss increases the likelihood of duodenal
compression by reducing the fat layer that protects the artery,
Background and aims.– Body dissatisfaction (BD) is defined as a
which is associated with nausea, vomiting, epigastric pain and
negative subjective evaluation of one’s physical body. It predicts
gastric distension, that may be perpetuators of food restriction.
development of disordered eating and is a necessary factor in emer-
Delayed diagnosis implies an increased risk of complications.
gence of eating disorders (ED).
In AN, patients with aorto-mesenteric angle narrowing may
Aim.– To investigate the relationship between body dissatisfaction
develop multiple complications during food reintroduction and
and disordered eating behavior.
episodes of food voracity.
Methods.– College students were recruited online, via Facebook,
Conclusions.– The complications of SAMS are life-threatening, and
during February 2018, to participate in an online survey on ED.
its early recognition and the adoption of preventive therapeutic
We used an anonymous self –questionnaire composed of 43 items
strategies are important. The progressive weight gain has been
to record sociodemographic and clinical data.
shown to be essential as a therapeutic intervention. However,
The “Eating Attitudes Test” and the “Contour Drawing Rating Scale”
evaluation by Gastroenterology/General Surgery must not be dis-
(CDRS) were used to evaluate ED and BD.
pensed.
Results.– The mean age of students was 17 years. 57.1% of the sam-
ple was girls. Body mass index average was 21.21. The prevalence
interest statement.
of ED was 33.3%. According to the CDRS, the majority of both male
(61.1%) and female (75%) participants selected an ideal figure dif-
E-PV0304 ferent from their current figure. Boys were as likely to want to
be heavier (22.2%) as to be thinner (38.9%) whereas only 2 girls
Eating disorders and self-esteem in
expressed a desire to be heavier (8.3%) and a very large portion
college students (66.7%) chose an ideal figure that was thinner than their current
I. Lajmi* , F. Guermazi, R. Sellami, I. Baati, M. Moalla, I. Feki, J. figure. Compared with the boys, girls expressed greater weight dis-
Masmoudi satisfaction, and had higher rates of abnormal eating attitudes and
Psychiatry, Department of Psychiatry A- Hedi Chaker University behaviors (37.5% vs 27.8%, p = 0.37). But among ED group, 100% of
Hospital, Sfax, Tunisia boys and 88.9% of girls were unsatisfied about their one’s body.
Conclusions.– Our study highlights that BD and ED were more fre-
quent among girls and have a relationship between each other.
Background.– The eating disorders (ED) are real addictive behavior
interest statement.
that may causes real suffering for the patient and affect his self-
esteem.
Aims.– To estimate prevalence rate of ED.
E-PV0306
To investigate dysfunctional eating behaviors and relationships
between ED and low self-esteem. Trauma, emotion regulation
Methods.– A 47-item anonymous online survey was conducted difficulties and binge eating
among college students (N = 42), via Facebook, on February 2018 C. Alves1 , M. Marques2* , A.C. Ribeiro1 , P. Correia1 , S. Soares1 , P.
designed to record some sociodemographic and clinical data. Silva1 , L. Lemos3 , S. Simões3 , B.R. Maia4
1 Miguel Torga Higher Institute, Research and Development
We used the “Eating Attitudes Test” (EAT26) and the “Rosenberg
self-esteem scale” to evaluate ED and self-esteem. Department, Coimbra, Portugal; 2 Miguel Torga Higher Institute
Results.– The mean age of participants was 17 years, with a sex ISMT, Research and Development Department ISMT- Clinical
ratio of 0.75. Body mass index average was 21.21 kg/m2 (it ranged Psychology Unit CHUC, Coimbra, Portugal; 3 Miguel Torga Higher
between 17.11 and 30.08 kg/m2). 7.2% of students have overweight Institute, Research and Development Department, Coimbra, Portugal;
4 Faculty of Philosophy and Social Sciences, The Catholic University of
or obesity. Regular physical activity was reported by 38.1% of them.
According to Rosenberg self-esteem scale, 81% of subjects were Portugal- Regional Centre, Braga, Portugal
classified as low or very low self esteem with a mean score of
27.16. The prevalence of ED in students was 33.3% with mean score
Background and aims.– The growing research interest in binge eat-
of 15.71. This prevalence of ED is higher among girls than boys
ing symptoms is associated to its high comorbidity with obesity
(37.5% vs 27.8%, p = 0.508). BMI score was higher in eating disor-
and psychiatric symptoms, its related health complications and
der group but the relationship was not significant. Low or very low
growing prevalence rates. As a multidetermined phenomenon, it
self esteem were frequent among eating disorder group (64.3%)
is crucial to continue exploring its correlates, particularly in the sive, rigid and repetitive way can lead to physical and psychosocial
general population (not only in clinical samples). Our main goals dysfunction.
are: to explore if traumatic experiences ocurrence and emotional Disclosure of interest.– The authors have not supplied a conflict of
regulation difficulties are associated with (and predict) binge eating interest statement.
symptoms; to verify if emotional regulation difficulties mediate the
relation between having experienced traumatic experiences and
binge eating symptoms. E-PV0308
Methods.– 421 university students and adults from the general Intimate violence is associated with
population (women, n = 300, 71,3%) answered a sociodemographic increased risk of eating disorders and
questionnaire, the Traumatic Events Checklist (TEC), the Difficul-
disordered eating behaviors in
ties in Emotion Regulation Scale (DERS) and the Binge Eating Scale
(BES). women: a cross-sectional study
Results.– 5.9% of the sample presented mild to moderate binge L. Mattar* , N. Zeeni
eating symptoms and 2.6% severe binge eating symptoms, sim- Lebanese American University, Natural Sciences, Beirut, Lebanon
ilar values to those found in Portuguese studies using the BES.
Binge eating total score positively correlated with family trauma Background and aims.– Verbal, physical or sexual violence against
and traumatic experiences total score (TEC). It also positively corre- women is a wide spread phenomenon; one out of three women
lated with impulses, non-acceptance, objetives, strategies and lack experience intimate partner violence (WHO). Consequently, this
of emotional clarity (DERS), and with Body Mass Index (BMI). The exposure to violence potentially leads to various health effects,
binge eating total score, reported weight at childhood, BMI, trau- ranging from fertility issues to significant changes in the woman’s
matic experiences total score and strategies (DERS) significantly eating behavior which might lead to the development of serious
predicted binge eating total score. We did not found any mediation Eating Disorders (ED). Very few studies investigated the effect
effect. of receiving violence on increasing the risk of disordered eating
Conclusions.– These results show the importance of traumatic life behavior (DEB) and ED. This study aims to investigate the effect
experiences and of emotion regulation difficulties as correlates of of different type of violence exposure on the risk of ED and DEB
binge eating symptoms, in a sample of university students and development in women.
people from the general population. Methods.– Women aged between 18 and 45 who have experienced
Disclosure of interest.– The authors have not supplied a conflict of any form of violence were recruited (contacted through various
interest statement. local NGOs) along with a matching control group of women not
having experienced violence. Screening for ED and assessment of
DEB and violence level were conducted through validated question-
E-PV0307
naires. Institutional Review Board approved the study and written
Orthorexia nervosa: when healthy consent forms were obtained.
eating becames a problem Results.– Total violence and sub-scales are all a risk factor for
F. Martins Alves1* , A. Fornelos2 , I. Brandão3 DEB (external, emotional and restraint eating). Physical and sexual
1 Local Health Unit of Alto Minho- EPE, Department of Psychiatry and violence increased the risk for ED. Age, total violence score and edu-
Mental Health, Viana do Castelo, Portugal; 2 Hospital Center of cational level were found to be independent predictors of external
Trás-os-Montes e Alto Douro- EPE, Department of Psychiatry and eating.
Mental Health, Vila Real, Portugal; 3 Hospital Center of São João, Conclusions.– This is a pioneer study investigating the effect of vio-
Psychiatry and Mental Health Clinic, Porto, Portugal lence on the risk of developing ED and DEB in women. Women
exposed to various type of violence should be a high priority group
for ED intervention and prevention, the latter being generally focus-
Background and aims.– Food is essential to life. Globalization has ing only on adolescent women.
led to excessive worship for a “perfect” body image and the valuing Disclosure of interest.– The authors have not supplied a conflict of
of healthy lifestyles as a way to prevent chronic and potentially interest statement.
disabling diseases.
With this work, we pretend to disseminate the concept of
Orthorexia Nervosa, understand its characteristics and possibly E-PV0309
harmful consequences.
Cutaneous hyperpigmentation in a
Methods.– A literature review using the MEDLINE® database. The
keywords “orthorexia nervosa” and “eating disorders” were used. diagnosed tca patient, a case report
Selected articles based on the content and relevance of the abstract L. Niell Galmés1* , M.S. Hernandez Pignatta2 , G. Montero
and date of publication (from 2015 to present). Hernandez3 , I. Alberdi-Paramo3
1 Hospital Universitario Infanta Sofía, Department of Psychiatry and
Results.– Orthorexia Nervosa was first described in 1997. Currently,
it is estimated that its prevalence varies between 6.9% in the general Mental Health, San Sebastian de los Reyes, Spain; 2 Lateral Psicología,
population and 57.8% in populations at risk. It is characterized by Directora, Madrid, Spain; 3 Hospital Clínico San Carlos,
a pathological obsession directed at the quality of food in order to Departamento de Psiquiatría y Salud Mental, Madrid, Spain
optimize physical health and well-being. Instead of changing the
quantities of food, there is a demand for healthier, pure and natural Background and aims.– Patients diagnosed with eating disorders
foods. However, an extreme preoccupation with food, time spent often suffer physical complications due to their eating patterns.
in planning and obtaining it, and restricting food variety can lead to Although they are not the most frequent, complications at the liver
nutritional deficits, severe weight loss, and organic complications. level are common.
Conclusions.– The change in eating patterns has created an envi- To illustrate to the clinicians about a benign, infrequent and easy
ronment conducive to the emergence of new pathologies of eating to diagnose cause of a common complication in patients diagnosed
behavior. Adherence to a rigorous and healthy diet is seen in the with eating disorders.
Western world as acceptable and desired, generating feelings of Methods.– We expose a case and make a brief reflexion.
admiration for others. It is important to become more aware that Results.– 35-year-old woman diagnosed with restrictive Anorexia
the behaviors characteristic of orthorexics, performed in an obses- Nervosa of many years of evolution with a torpid evolution that
goes to the Dia Hospital with a strikingly yellowish coloration on Anorexia nervosa and bulimia nervosa are among the most com-
the skin (predominantly on the palms of the hands) without any mon chronic diseases in adolescents and young adults (Garner,
other symptomatology in the anamnesis. A jaundice is suspected 2004). Among inappropriate compensatory behaviors such as
and a study is initiated to determine the cause. induced vomiting or laxative abuse, excessive physical exercise
Complete Physical and Analytical Examination with a hepatic pro- (EPE) is very worrisome for clinical teams since exerciser patients
file that is anodyne is performed. When no alterations are found, often have poorer prognoses than non-exerciser patients (Stiles-
a new anamnesis is carried out focused on less frequent causes in Shields et al., 2015). EPE is defined as an abnormal amount of
the differential diagnosis detecting a diet based on carrots. physical activity combined with a compulsion to exercise. Although
Conclusions.– Jaundice is considered to be the yellowing of skin, the relation between poor physical self-concept and ED is well
membranes, mucous membranes and body fluids as a consequence established (APA, 2013), to our knowledge the relation between
of an increase in bilirubin. It is important to differentiate it from physical self-concept and EPE has never been studied. This research
carotenoderma, that is, from cutaneous hyperpigmentation due to aims to document the relation between physical self-concept and
the accumulation of carotenoids. In this case, mucous discoloration EPE. The sample of this cross-sectional study comprises ED patients
is not observed and usually predominates in palms and soles. between the ages of 14 and 26 years who participate in a ED inter-
Carotenoderma is a rare cause of skin pigmentation that differs vention program. The Physical Self-Inventory (Maiano et al., 2008)
from jaundice in the non-involvement of mucous membranes. and the Exercise and Eating Disorder test (Danielson et al., 2014) are
Therefore, it is important to perform a detailed physical exam- used to measure variables. Preliminary results based on 15 patients
ination to avoid unnecessary tests or even invasive diagnostic indicate that there is a positive relation between sport competence
procedures. and EPE quantity (r = 0,650, p.
Disclosure of interest.– The authors have not supplied a conflict of Disclosure of interest.– The authors have not supplied a conflict of
interest statement. interest statement.
E-PV0310 E-PV0312
Excessive physical exercise in eating The role of rumination in the
disorders: a conceptual discussion relationship between perfectionistic
M. Ouellet* , J. Monthuy-Blanc
self-presentation and eating
University of Québec at Trois-Rivières, 3351, Boul. des Forges,
Trois-Rivières, Québec (Canada) G8Z 4M3 psychopathology
* Corresponding author. R. Silva1 , C. Marques2 , A.T. Pereira2* , A. Macedo2,3
1 University of Coimbra, Faculty of Medicine, Coimbra, Portugal; 2
Excessive physical exercise (EPE) is a common inappropriate com- Faculty of Medicine - University of Coimbra, Institute of Psychological
pensatory behavior, as induced vomiting or use of laxative, often Medicine, Coimbra, Portugal; 3 Hospital and University Centre,
employed by patients with an eating disorder. The lifetime preva- Psychiatry Department, Coimbra, Portugal
lence of EPE varies between 26% and 80% depending on the samples
and measures (Davis & Kaptein, 2006; Levallius, Collin & Birgegard,
2017). EPE is defined as an abnormal amount of physical activity Background and aims.– Rumination is defined as a maladaptive
combined with a compulsion to exercise. This behavior leads to emotion regulation strategy where the individual has compulsive
harmful psychosocial and physical consequences such as impaired and repetitive thoughts on the meaning, causes and consequences
social relations, injuries, potassium drops risk and death often of his distress. It is generally accepted a bidimensional model of
involve cardiac arrest or suicide. This symptom is very worrisome rumination – brooding and reflection. Specific rumination about
for clinical teams because exerciser patients have poorer prognoses eating, weight and shape has been consolidated in the literature
than non-exerciser patients (Stiles-Shields et al., 2015). Although as a core feature in eating psychopathology. Perfectionistic self-
most inappropriate compensatory behaviors are well controlled presentation, as a personality trait concerning the need to appear
during hospitalization, the use of EPE remains frequent and per- perfect to others, has also shown a particular association with eat-
sistent during intervention programs, as well as after recovery, ing psychopathology, and ruminative thoughts on eating, weight
thereby leading to a higher risk of relapse (Meyer, Taranis, & Touyz, and shape may have an important role in the maintenance of that
2008). However, it is difficult for clinical teams to assume care for relation.
this symptom because of the lack of empirical knowledge about Objectives.– The present study analyses the mediating role of
EPE. This could be explained by the polysemy leading to a multitude brooding and reflection in the relationship between perfectionis-
of definitions in the literature referring to EPE (Probst et al., 2014). tic self-presentation and eating psychopathology, controlling for
If some authors consider only the quantitative component of EPE gender.
in their studies, others use only the compulsive component, while Methods.– A total of 98 university students (57 females and
still others consider both. This problem could lead to biased results. 41 males) completed a battery of self-report scales measuring
The necessity to consider both the quantitative and compulsive perfectionistic self-presentation, rumination and eating psy-
components of EPE in researches will be discussed. chopathology.
Disclosure of interest.– The authors have not supplied a conflict of Results.– All the variables showed significant and positive cor-
interest statement. relations (0.26–0.78) between them. Moreover, the mediation
analyses revealed that both ruminative reflection and brood-
ing on eating, weight and shape concerns are mediators of the
E-PV0311 relationship between perfectionistic self-presentation and eating
Relation between physical psychopathology.
self-concept and excessive physical Conclusions.– These findings seem to show that perfectionistic
exercise in eating disorders: self-presentation may impact on eating psychopathology through
rumination (both brooding and reflection). Also, therapeutic and
preliminary results prevention strategies can target perfectionistic self-presentation
M. Ouellet* , J. Monthuy-Blanc
and rumination on eating, weight and shape concerns to diminish
University of Québec at Trois-Rivières, 3351, boul. des Forges,
eating psychopathology.
Trois-Rivières, Québec (Canada) G8Z 4M3
Disclosure of interest.– The authors have not supplied a conflict of presentation of rare fatal anorexia nervosa case with extremely
interest statement. low BMI with particular attention paid to the histopathological
changes in the heart.
Methods.– Analysis of available medical records and post-mortem
E-PV0313 findings.
Eating disorders: a literature review Results.– The body of a 24-year-old girl was disclosed by her sis-
and case study ter in their flat. The prosecutor decided to order the medicolegal
H. Raai* , M. Rovner, H. Forman, M.A. O’Dowd autopsy. Post mortem BMI was 9.3 (157 cm, 23 kg). Except the
Montefiore Medical Center / Albert Einstein College of Medicine, features of extreme cachexia and typical symptoms of sudden
Department of Psychiatry and Behavioral Sciences, New York, USA death there were no other lesions. The weight of the heart was
* Corresponding author. 93 g, while in the woman’s age it should be about 160 g. Detailed
cardiopathological examination revealed mainly the features of
Background and aims.– The aim of this study is to critically review severe atrophic changes in all microstructures: cardiomyocytes,
the literature of eating disorders, exploring prevalence, clinical parasympathetic ganglia, vascular endothelial and smooth mus-
features, comorbidities, and, association of eating disorders with cle cells. In general, the histopathological image of the heart
suicidal ideation and attempts. We will also discuss the case of a analyzed under smaller magnification resembled intriguingly a
23-year-old woman with anorexia nervosa, who was admitted to morphology typical for neonatal organ. In the course of the inves-
the medical unit due to a hypoglycemic episode in the context of tigation, it turned out that woman had been suffering from AN
refusing to eat or drink for several days and excessive exercise. for 9 years. At that time, she was in the outpatient clinic only
Methods.– Case study and literature search of the terms “Anorexia twice and once she was hospitalized in a psychiatric ward for
Nervosa”, “Bulimia Nervosa” and “Eating Disorders” using PubMed several days.
and selected relevant articles published in last 10 years in peer- Conclusions.– If left untreated, AN causes serious, life-threatening
reviewed journals. atrophic changes in the myocardium which may often result in
Results.– The etiology of eating disorders is unknown and probably sudden functional death.
multifactorial. Environmental influences, such as societal idealiza- Disclosure of interest.– The authors have not supplied a conflict of
tion about weight and body shape, play a major role. The review of interest statement.
the literature has shown that eating disorders have a high level of
comorbidity with other psychiatric disorders, such as anxiety dis-
order and depression. Patients with eating disorders have a high E-PV0315
rate of suicidal ideations and attempts and have the highest mor- Learning problems in adolescent girls
tality rate of any mental disorder. Recent evidence suggests that with anorexia nervosa
cognitive-behavioral therapy is often effective treatment for eat- N. Zvereva1* , S. Voronova2
ing disorders. Antidepressants, including SSRIs, may help mitigate 1 FBSI MHRC- MSUPE, Clinical Psychology, Moscow, Russia; 2 Mental
symptoms of depression and suicidal ideations in these patients. Health Research Center, Department of Clinical Psychology, Moscow,
Collaboration between different specialties may optimize treat- Russia
ment outcome. * Corresponding author.
Conclusions.– Physicians need to be diligent in screening patients
for eating disorders, evaluate for other comorbid psychiatric con- Background and aims.– Now days the number of adolescents with
ditions and conduct a thorough suicide risk assessment. eating disorders increases, anorexia nervosa (NA) is one of them.
Disclosure of interest.– The authors have not supplied a conflict of Having psychiatric diagnosis adversely affects the education of
interest statement. girls. We know specific features of patients with NA, found mainly
in adult patients: perfectionism, social desirability, desire to show
better results. Due to traumatic situation, activities aimed at learn-
E-PV0314 ing and social activity are shifting to desire to correct real or
Fatal anorexia nervosa case with imaginary shortcoming. The motive shifts to the goal, and leading
extremely low BMI – an important activity is replaced. Psychological studies of girls with NA showed
the presence of high motivation for achievements, and distortion
correlation between clinical
of self-perception.
pathology and forensic medicine Aim Evaluation characteristics of educational trajectory of patients
R. Skowronek1* , I. Jelonek2 , A. Skowronek3 , A. Pałasz4 , P. Paleń5 , R. with NA in child psychiatry department.
Wojnicz6 Methods.– 27 girls (10-16 years old) with NA treated at child psy-
1 Medical University of Silesia in Katowice, Department of Forensic
chiatry department of Mental Health Research Center were quality
Medicine and Forensic Toxicology, Katowice, Poland; 2 Medical assessed in anamnesis including learning problems and educational
University of Silesia in Katowice, Developmental Age Clinical Ward- trajectory.
Department of Psychiatry and Psychotherapy, Sosnowiec, Poland; 3 Results.– Data on the analysis of anamnestic materials related to
Outpatient Clinic for Mentally and Nervous Sick NZOZ “Integritas”, the learning process are presented. Patients were divided into 2
Outpatient Clinic for Mentally and Nervous Sick NZOZ “Integritas”, groups: first (56%) - patients without learning problem, second
Oświ˛ecim, Poland; 4 Medical University of Silesia in Katowice, (44%) - patients experience learning difficulties. Girls in first group
Department of Histology, Katowice, Poland; 5 Medical University of were younger than in second, and did not have such a long illness.
Silesia in Katowice, Department of Pathomorphology and Molecular Conclusions.– NA in adolescents is often referred to as “excel-
Diagnostics, Katowice, Poland; 6 Medical University of Silesia in lent pupil disease”, our empirical and clinical data do not confirm
Katowice, Department of Histology and Cell Pathology, Zabrze, Poland this NA characteristic completely, especially considering the dif-
ferent stages of the disease development and the age of onset.
Background and aims.– Anorexia nervosa (AN) is considered the The question of the fate of a girl with NA and the presen-
most lethal among all psychiatric disorders. It is relatively rarely tation of adaptive or non-adaptive behaviors requires further
seen in forensic medical practice, but sometimes sudden death research.
of the young people raises suspicions of the prosecutor regarding Disclosure of interest.– The authors have not supplied a conflict of
the circumstances and mechanism of death. The objective was interest statement.
E-Poster Viewing - 7–9 April: Emergency agitation during last month. At clinical examination, we found a
Psychiatry conscious patient but reluctant, disoriented, agitated with delu-
sions and visual hallucinations. Neurological exam was normal. All
her biological tests were normal. Cerebral CT-Scan and MRI showed
venous thrombosis of the left lateral sinus and left jugular vein. Our
E-PV0316 patient was kept on heparin then switched by vitamin K antagonist
Psychiatric disorders revealing with a good clinical outcome.
neurobrucellosis: about a case report Conclusions.– This case raises the importance of considering cere-
M.H. Aoun* , S. Zouari, H. Hadj Kacem, O. Hdiji, N. Farhat, S. Sakka, bral sinus venous thrombosis among patients with confusion status
M. Damak, C. Mhiri associated with psychiatric disorders evolving for a short period.
Habib Bourguiba, Neurology, Sfax, Tunisia Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– Brucellosis is caused by a gram-negative

aerobic bacteria belonging to the Brucella genus. This disease is E-PV0318
endemic in Tunisia. Its neuropsychiatric presentation accounts for A resistant depression revealing
1.7 to 10% of cases. Here we describe a case with a twelve month
history of psychiatric impairment, who was later diagnosed with
neuropsychiatric Behçet disease:
neurobrucellosis. about a case report
Methods.– This is a 48-year-old male patient, with a history of raw M.H. Aoun* , O. Hdiji, H. Hadj Kacem, S. Sakka, N. Farhat, M. Damak,
milk consumption, who presented at our department for psychi- C. Mhiri
atric disorders that have been evolving for an year. We reviewed Habib Bourguiba, Neurology, Sfax, Tunisia
his clinical and paraclinical data.
Results.– At questionnaire, the patient’s relatives reported recurrent
Background and aims.– Behçet’s disease is a multisystem panvas-
transient confusional states associated with psychomotor agitation
culitis of unknown etiology originally described as a syndrome of
and insomnia during last year. Few months before his admission,
oral ulcers, genital ulcers, and iritis. Neuropsychiatric involvement
he became displaying atypical absences. Later, our patient suf-
occurs in about 20% of the cases, usually as a transient but some-
fered from severe headache and vomiting, which motivated his
times fatal episode of acute illness. Psychiatric presentation has
admission. At clinical examination, we found a conscious patient
not been well described. Dementia has been reported occasionally.
but reluctant, disoriented, agitated without delusions nor halluci-
Here we describe a case with a twelve month history of psychi-
nation. He also exhibited hypoacusis and a stiffness of the neck.
atric impairment, who was later diagnosed with Neuropsychiatric
Cerebrospinal fluid analysis showed hyperalbuminorrachia, hypo-
Behçet Disease.
glycorrachia and elevated white elements counts with isolation
Methods.– This is a 50-year-old male patient, without any medical
of Brucella SPP species on cultures. Wright serology was positive
history, who presented at our department for psychiatric disorders
at 1/320. Brain MRI showed sub-cortical white matter hyper-
that have been evolving for a year. We reviewed his clinical and
intensities without gadolinium enhancement. Our patient was kept
paraclinical data.
on antibiotic with a good clinical outcome.
Results.– The patient was a father of four children. His wife commit-
Conclusions.– This case raises the importance of considering neuro-
ted suicide. Then he developed sadness, anorexia, asthenia, weight
brucellosis among patients with psychiatric disorders originating
loss. He consulted a psychiatrist. At examination, the patient had
from endemic regions.
depressed mood, anhedonia, psychomotor slowdown and loss of
vital momentum. He was prescribed antidepressants. His depres-
interest statement.
sion was resistant against three types of antidepressants for eight
months. Later, the patient developed progressive worsening mem-
ory loss, disabling tremor and urinary signs. At clinical examination
E-PV0317
we found a conscious patient but disoriented. The patient had
Cerebral sinus venous thrombosis Dementia Syndrome, Parkinson’s syndrome, oculomotor disorders
revealed by psychiatric disorders: and vesico-sphincteric disorders. Brain MRI showed demyelinating
about a clinical case lesions of basal ganglia. Cerebrospinal analysis revealed a meningi-
M.H. Aoun* , O. Hdiji, N. Farhat, S. Sakka, H. Hadj Kacem, M. Damak, tis and ophthalmological examination showed uveitis. The patient
C. Mhiri was diagnosed with Neuropsychiatric Behçet Disease and he was
Habib Bourguiba, Neurology, Sfax, Tunisia kept on immunosuppressors (Cyclophosphamide). Sixth months
* Corresponding author. later, the patient died.
Conclusions.– This case raises the importance of considering organic
Background and aims.– Cerebral sinus venous thrombosis (CSVT) is causes among patients with resistant depression.
a rare phenomenon that can be seen among old and young patients. Disclosure of interest.– The authors have not supplied a conflict of
CSVT is a multifactorial condition with gender-related specific interest statement.
causes, with a wide clinical presentation. The leading causes dif-
fer between developed and developing countries, converting CSVT
in a condition characterized by a highly variable clinical spectra, E-PV0319
difficult diagnosis, variable etiologies and prognosis that requires A case of paraneoplastic limbic
fine medical skills and a high suspicious index. Here we describe a
case with one month history of psychiatric impairment, who was
encephalitis during the course of
later diagnosed with cerebral sinus venous thrombosis. depression
Methods.– This is a 64-year-old female patient, with a history of M.H. Aoun* , S. Sakka, N. Farhat, H. Hadj Kacem, O. Hdiji, M. Damak,
atrial fibrillation and phlebitis, who presented at our department C. Mhiri
for psychiatric disorders that have been evolving for one month. Habib Bourguiba, Neurology, Sfax, Tunisia
We reviewed his clinical and paraclinical data.
Results.– At questionnaire, the patient’s relatives reported con-
fusion, delirium, disrupted attention, having visual delusions,
Background and aims.– Limbic encephalitis is characterized by irri- Post traumatic stress disorder, depressive and anxiety disorders,
tability, depression, sleeping disorders, seizure, hallucination and and substance abuse are the most reported in survivors.
short-term memory loss. Most of the patients evolve with confu- Conclusions.– Psychiatrists play a pivotal role in a disaster setting
sion and epileptic temporal lobe seizures. Previously associated and contact with this kind of interventions should be promoted.
with cancer, recent evidence suggests that limbic encephalitis in Disclosure of interest.– The authors have not supplied a conflict of
fact more often occurs independently of cancer, as an autoimmune interest statement.
phenomenon.
Methods.– Here we describe a first case report with a two-week
history of psychiatric impairment, who was later diagnosed with E-PV0321
Limbic Encephalitis. The acute psychotic disorders in
Results.– This is a 32-year-old female patient, with a history of Thy- patients with alcoholic dependence in
roid Papillary carcinoma. She had a total thyroidectomy in 2015
withdrawal state of alcohol
with Iodotherapy. She had been taking since Levothyroxin. She
V. Kuzminov
presented apathy, anorexia and adynamia with memory loss. Two
SI «Institute of Neurology- Psychiatry and Narcology of NAMS of
weeks later, she presented an epileptic seizure. She was started
Ukraine», Department of Emergency Psychiatry and Narcology,
on carbamazepine 400 mg/day. Laboratory assessment and Cere-
Kharkiv, Ukraine
brospinal fluid (CSF) were normal. CSF was negative for herpes * Corresponding author.
simplex virus via PCR. CSF cytology was negative, and CSF protein
electrophoresis did not identify any oligoclonal bands. MRI of the Background and aims.– The abstract presents the results of long-
brain showed hyperintense signals from both hippocampi, highly term studies of patients with acute psychotic disorder in 560
suggestive of limbic encephalitis presenting as a paraneoplastic patients with alcohol dependence that has emerged in the state
manifestation of papillary carcinoma. EEG showed a disorganized of alcohol withdrawal (primary hospitalization in the framework
background with bitemporal slowing consistent with encephalopa- of this study).
thy. The most of them were examined in a dynamics after a re-
Conclusions.– Paraneoplastic neurological syndromes are rare hospitalization after 5 years due to acute psychosis.
occurring in less than 1% of patients with malignancies. It is The purpose of the study was to study the factors affecting the
important to consider paraneoplastic syndromes such as limbic severity and clinical picture of acute psychotic disorders in the state
encephalitis early on when incongruous neuropsychiatric symp- of alcohol withdrawal.
toms are present, as early diagnosis of malignancy and prompt Methods.– Clinical psychopathological, electrophysiological, statis-
initiation of treatment can lead to improvement in the neuropsy- tical, catamnestic.
chiatric manifestations. Results.– The polyetology of acute psychotic disorders in patients
Disclosure of interest.– The authors have not supplied a conflict of with alcohol dependence in the state of withdrawal was shown. At
interest statement. the same time it has been proved that in repeated hospitalizations,
met alcoholic psychosis in most cases repeats the clinical picture
of the primary clinical episode. The influence of the factors of per-
E-PV0320 manent and temporary on the clinical picture and the pathology of
Disaster management and psychiatry: alcoholic delirium have been studied. The impact of acute psychotic
a review disorders on the course of alcohol dependence, including the for-
J. Fonseca* , E. Machado, R. Rodrigues mation of cognitive deficits was estimated. However, the reverse
Hospital Senhora da Oliveira- Guimarães, Psychiatry and Mental effect cognitive deficits on the severity of the psychotic disorder
Health, Guimarães, Portugal (assessed by the duration of the psychotic disorder and the threat
* Corresponding author. to life) were significantly less.
Conclusions.– The severity of the acute psychotic disorder in the
Background and aims.– Everyday people are exposed to disasters state of alcohol withdrawal mostly depended situational factors
and traumas that strike unexpectedly and bring devastating phys- such as the number of days of severe drinking before a psychotic
ical and psychological consequences for the communities facing disorder, the pattern of nutrition, the quality and quantity of alcohol
them. Disasters derive from disruptive events, such as natural consumed, the presence of acute somatic diseases.
calamities or human destructive acts, overcoming the adaptive Disclosure of interest.– The authors have not supplied a conflict of
capacity of a social group. interest statement.
This scenario is very different from the regular clinical activities
psychiatrists have to do, and faces them with challenges when an
intervention is suddenly needed. E-PV0322
It is known that early interventions are important to help survivors Wernicke’s encephalopathy and
mitigating suffering and to detect psychiatric symptoms in those
bipolar disorder at the emergency
affected before some chronic condition develops.
The aim of this work is to review the role of psychiatry in emergen- unit: a case report
cies management. D. Rentero* , I. Torío, M. Caballero-González, E.M. Sánchez-Morla,
Methods.– We proceeded to an electronic research of the latest M. Aragües, R. Rodríguez-Jiménez
articles in “Pubmed” as well as of consensus regarding disaster Hospital Universitario 12 de Octubre, Psychiatry, Madrid, Spain
psychiatry.
Results.– In the aftermath of a disaster people tend to react in a Background and aims.– Wernicke’s encephalopathy is the presence
particular pattern divided into a heroic phase, honeymoon phase, of neurological symptoms caused by biochemical lesions of the
disillusionment phase and restoration phase. central nervous system after exhaustion of B-vitamin reserves, in
The disillusionment phase can last from 3 to 36 months and it is the particular thiamine (vitamin B1). The prevalence is around 2%, and
most critical period for an individual to develop a psychiatric disor- is considered underdiagnosed. Probably, many cases are in patients
der which is estimated to range from 8.6 to 57.3 percent. Although who do not have commonly-associated symptoms, as occur in
the risk is higher, not every people will be affected by a psychiatric patients with comorbid psychiatric diagnosis.
disorder, but sub-syndromal signs of distress may appear, mostly
somatic.
Methods.– We present a case of 57 years old man who arrived to E-PV0324

the emergency unit because of behavior disorders. “Psychiatry of catastrophes” in the
When we evaluated the patient, he had low level of consciousness. daily work of an outpatient
He presented myoclonus in all extremities and bilateral multidirec-
tional nystagmus. The patient had a previous diagnosis of bipolar
psychiatrist
disorder and in recent months he had been living in a caravan in L. Shapovalova1* , K. Shapovalov2
1 State Autonomous Health Agency of the Republic of Komi
unhealthy conditions, with a diet based on water intake exclusively.
Results.– Admission to the general hospital was carried out. After “Consultative and Diagnostic Center of the Republic of Komi”,
carrying out complementary tests, the patient had vitamin B1 defi- Consultative department, Syktyvkar, Russia; 2 State Education
ciency as well as other vitamins such as folic acid. After resolving Agency of Additional Professional Education of Republic of Komi
organic syndrome, a psychotic depression episode was diagnosed. “Komi Republican Institute for Development of Education”, Chair of
Probably, this episode led to the state of isolation and malnutrition Additional Education, Syktyvkar, Russia
that the patient presented from the last weeks before arriving at
the emergency unit. Background and aims.– The projected increase in anthropogenic,
Conclusions.– The coexistence of somatic and psychiatric diseases technic, social, military, terrorist, possible space disasters and
is not uncommon. As the case presented, when the symptoms are emergency situations (ES) attracts the attention of psychiatrists in
not completely clear and there are data of a certain organicity, it is connection with the need to provide specialized psychiatric assis-
important to work as a team with the rest of medical specialities tance to the victims.
ensuring an integral attention of our patients, always prioritizing Development of principles, strategy and tactics, methods and
the most serious pathology. means of providing timely psycho-psychiatric care.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– Analysis of the preparation of psychiatrist for outpatient
interest statement. counseling to work in emergency situations for 24 years.
Results.– The work of psychiatrist in the section “Psychiatry of
Catastrophes” is analyzed from the standpoint of: 1) Personal par-
E-PV0323
ticipation in the development of educational and methodological
Adult and pediatric frequent and lecture materials for preparing the population for actions in
attenders in the psychiatric emergency situations; 2) The actions of the doctor in the workplace
emergency department: impact and in medical institution with possible “everyday” emergencies - the
characteristics in a tertiary referral emergence of fire, the threat of a terrorist explosion; 3) Work in the
medical-nursing brigade of the civil defense system; 4). Participa-
hospital tion in the structure of psycho-psychiatric care for the population
M. Sagué Vilavella* , G. Anmella, S. Madero, J.E. Pinzón, A. Giménez,
in emergencies.
M.T. Pons, M. Vázquez, V. Soler, I. Méndez, E. Solé
Conclusions.– The psychiatrist must undergo special training in
Clínic Institute of Neurosciences- Hospital Clínic of Barcelona,
1) the Department of Anonymous Psychological and Psychiatric
Department of Psychiatry and Psychology, Barcelona, Spain
* Corresponding author. Assistance by phone; 2) an advisory visiting team of psycho-
psychiatric care; 3) Department of psychological and psychiatric
Background and aims.– care; 4) Cabinet of psychological and psychiatric care. Medical
Introduction.– Frequent attenders (FA) to psychiatric emergency workers who survived emergencies should be treated as victims,
departments affect quality of care and imply resource overuse. Prior who need comprehensive psycho-psychiatric care and careful cor-
studies suggest they are a growing phenomenon. porate support, with a gradual return to normal workloads. The
Objectives.– To determine the current impact of FA in the psychiatric contingent of professional rescuers under conditions of emergen-
emergency department. To characterize adult and pediatric FA and cies is exposed to the extreme factors of the current situation
identify differences compared to non-FA. and is a risk group for the development of affective spectrum
Methods.– Year 2017 psychiatric emergency department atten- disorders.
dance from Hospital Clínic of Barcelona (Spain) was analyzed, Disclosure of interest.– The authors have not supplied a conflict of
separately for adult and pediatric population. Frequent attendance interest statement.
was established as ≥5 visits/year. Comparison between FA and non-
FA was restricted to patients belonging to the hospital service area.
E-PV0325
Trend analysis included the 2012–2017 period.
Results.– 2.5% (n = 78) of adults and 3.2% (n = 22) of minors were Borderline personality disorder (BPD)
FA in 2017, generating 14.8% (n = 653) and 14.4% (n = 152) of the patients as frequent patients in
annual visits respectively. The number of FA showed a significant emergency psychiatry
increasing trend between 2012 and 2017. In adults, FA were signif- S.S. Sanchez* , L. Soldado R., A. Alvarado D., M.O. Solis, F. Vilchez E.,
icantly younger than non-FA, whereas in minors there were more C. Coca C., G.M. Ruiz M.
foreigners. Among FA, the chief complaint was anxiety (42.2%) in Complejo Hospitalario de Jaen, UGC Salud Mental, Jaen, Spain
adults and behavioral disturbance (72.7%) in children; the most * Corresponding author.
prevalent main diagnosis was psychotic disorder in adults (25,6%)
and behavior disorder in minors (40,9%); 96,2% and 100% were on Background and aims.– Borderline Personality Disorder (BPD) is
psychopharmacological treatment respectively (antipsychotics in one of the most common mental disorder in Emergency Psychi-
78.2% and 95.5%; ≥3 psychotropics in 55% and 22.7%); 18% and atry, nowadays. Symptoms usually appear as a critical situation,
50% lived in residential facilities; and social/family problems were personal problems and a conflictive environment.
identified in 21,8% of adults and 63,6% of minors. - To objectively describe the mention of BPD patients as frequent
Conclusions.– In our hospital, FA have increased in recent years users, due to repetitive medical attention, similar reasons for con-
and generate substantial workload. Both adult and minor FA sultation and a typical symptomatology in emergency areas.
are highly-medicated and socially-disadvantaged groups, although Methods.– A follow-up of 6 months study for 10 patients diagnosed
their diagnoses and social problems differ. as BPD, aged between 19 and 38, who come to the hospital repeat-
Disclosure of interest.– The authors have not supplied a conflict of edly, from 2 to 12 times per semester, with a total of 61 emergency
interest statement. medical care.
Results.– E-PV0327
- Average value of 6,1 urgent consultations of each patient during Rehabilitating through digital spaces:
6 months.
meta-ethnography review of studies
- The average age on emergency room is 28,5 years-old and there
are gender differences.
using discussion forums as means of
- The main problems are conjugal (50%) and parental (50%) rela- promoting either health policies or
tionships. health treatments
- Other personal problems such as: laboral and economic issues D. Sendler1 , M. Duplaga2*
(30%) and substance abuse (30%) specially. 1 Felnett Health Research Foundation, Laboratory of Forensic
- Prevalence of self-harm in women (66.6%) and suicidal behaviour Sexology- Legal Medicine- and Digital Ethnography, Staten Island,
in men (50%), related with impulsivity. USA; 2 Jagiellonian University Medical College, Department of Health
- Anxiety, impulsivity and depression are the main symptoms Promotion, Cracow, Poland
observed: 80%, 70% and 60%, respectively. * Corresponding author.
Conclusions.– High demand of these patients, usually in non-BPD-

specialized services, means a greater caregiver burden (Zarit Scale) Background and aims.– In the recent decade, many studies inves-
and difficulties for psychiatrist and medical personnel in urgency tigated use of discussion forums as a primary tool for promoting
room. It is estimated that BPD patients use to consult another health information among the Internet users. This study seeks to
doctors more than two to three times, during the follow-up as collect, analyze, and synthesize the main findings of these investi-
outpatients care. Psychosocial and educational approach to care gations in a systematic way.
is justified in the clinical units, where the objective is the clinical Methods.– We apply a qualitative systematic approach to collect,
habilitation and the treatment of social skills, which can contribute analyze, and thematically assess studies describing use of discus-
to reduce urgent consultations. sion forums as health promotion tool.
Disclosure of interest.– The authors have not supplied a conflict of Results.– The results of a thematic analysis yield nine themes
interest statement. - description of each study and summary of relevant applica-
tion of discussion forums follows: (1) Self-destructive behaviors
- approaches to helping help seekers, suicide prevention, coping
strategies for self-harming behaviors, and recovering from drug
E-Poster Viewing - 7–9 April: Epidemiology and addictions; (2) Medication use and drug abuse - using topical cor-
Social Psychiatry ticosteroids among parents caring for children with eczema and
use of oral antibiotics for the treatment of acne; (3) Health decision
making - processes of health decision making, information seek-
ing to improve health behaviors, and ascertaining how participants
E-PV0326
differentiate good from bad health information; (4) Parenting and
Analysis of some social recessive family life - developing best parenting practices, early parental sup-
factors in persons with schizophrenia port for first time fathers; (5) Eating disorders - support for young
S. Abdusattorov people with eating disorders, patient empowerment, and psycho-
Tashkent Medical Academy, Psychiatry and Narcology, Tashkent, logical support; (6) Disease-specific support - peer support for
Uzbekistan orthognathic patients, patient attitude toward measles-mumps-
rubella vaccination side effects, complex regional pain syndrome,
pain management for children, and maintenance of health lifestyle
Background and aims.– To study the dependence of relapsing in type 1 diabetes.
schizophrenia on social factors. Conclusions.– This analysis shows that discussion forums have mul-
Methods.– The study was conducted on the basis of the “City Clinical tiple applications in health promotion, facilitating networking for
Psychiatric Hospital” in Tashkent, Uzbekistan. The inclusion con- patients and healthcare workers.
ditions: the acute stage; re-treatment of patients in a psychiatric Disclosure of interest.– The authors have not supplied a conflict of
hospital in 2017–2018; the socio-professional status of patients; interest statement.
marital status. 200 case histories were studied.
Results.– The patients were distributed as follows: men were 90
(45%), women-110 (55%). When diagnosed with ICD-10, F20.0-75%, E-PV0328
F20.6-5%, F20.8-20%. There were more than half of the women, the
Preliminary study of occupational
diagnosis of paranoid schizophrenia prevailed. 81% of patients not
working for health reasons, having a mental illness disability (73%) stress among Moroccan workers
were noted. The proportion of the level of social maladjustment H. El Hassouni1* , F.Z. Azzaoui Azzaoui1 , A. Ahami1 , H. Hami2 , S.
of patients in general corresponds to the proportion of the level of Boulbaroud3 , M. Elhioui1
1 Unit of Cognitive and Behavioral Neuroscience and Applied
disability due to mental illness. 57% of patients are divorced/live
separately, 29% are single/never married, 14% have a family. The Nutrition- Faculty of Science, Department of Biology, Kenitra,
data obtained allows to identify social risk factors: a reduced level Morocco; 2 Laboratory of Genetics and Biometry- Faculty of Science,
of social and labor adaptation; absentation of family; the presence Department of Biology, Kenitra, Morocco; 3 Polydisciplinary Faculty,
of disability due to mental illness. Department of Biology, Beni Mellal, Morocco
Conclusions.– To prevent exacerbations of schizophrenia, it is nec-
essary, to also pay attention to the social risk factors for relapse. In Background and aims.– Work-related stress has been defined as an
schizophrenia, there is a lack of need for communication, a decrease emotional, cognitive, behavioral and physiological response to the
in the will and impoverishment of the emotional sphere of patients. harmful and negative aspects of the work and its environment. It
As a result of these violations, social adaptation of patients worsens. can lead to significant difficulties in the professional environment.
Most of them have not family, job, other social communications. A The aim of this study is to evaluate the level of professional stress
sufficiently level of social and labor adaptation is impossible within workers of the Industrial district (Bab Fes), Kenitra (North-West
out the active participation of the patient. of Morocco).
interest statement.
Methods.– A sample of 100 workers (75 men and 25 women) aged Methods.– For people with narrow schizophrenia (n = 137), affective
between 19 to 60 years, is recruited. A stress evaluation is realized psychoses (n = 100), and non-psychotic affective disorders (n = 659)
using the “Perceived Stress Scale”. onset age was analyzed (quartiles for each diagnose) from register
Results.– Preliminary results showed that 54% of the participants data. A yearly employment rate for years 1979–2015 and edu-
present a perpetual threat, 34% face stress and 12% know how to cational outcome by year 2014 (completion of basic level, upper
manage their stress. According to their professional status, 36% of secondary or tertiary education) was compared between diagnostic
workers present a perpetual threat to stress against 18% of adminis- groups and between those having earlier versus later age of ill-
trators, while 17% and 6% of both categories face stress and manage ness onset by using regression analysis. Cohort members without
their stress respectively. psychiatric diagnosis were the control group.
Conclusions.– The frequency of stress in the study population is Results.– For education, individuals with an early onset schizophre-
important. In-depth research is needed to properly study this nia had 6-fold odds and affective psychosis 5-fold odds for
health problem. achieving only basic level education compared to peers. Figure 1
Disclosure of interest.– The authors have not supplied a conflict of depicts the results for yearly mean employment rate per diagnoses
interest statement. and onset age groups. In psychotic disorders, especially in narrow
schizophrenia, the employment rate is low compared to other
diagnoses and peers. People with an earlier onset tend have poorer
E-PV0329 employment rates than the ones with a later onset.
Revolving doors
M.J. Gordillo Montaño* , S.V. Boned Torres, M. de Amuedo Rincon,
E. Sanchez Navarrete, M. Guisado Rico, J. Iglesias Lopez
Hospital Can Misses, Psychiatry, Eivissa, Spain
Background and aims.– There is a tendency of making short incomes,

appearing the revolving door phenomenon. There is no consensus
in the literature to refer to a re-admitted patient. One of the criteria
is to have three or more income in one year. We have different
predictors of re-entry on which we use for taking the variables of
the study. We hypothesized whether the patients with multiple
admissions present a common pattern.
Methods.– A quantitative, observational, descriptive, transversal
and retrospective study of a population compounded of patients
admitted in 2017 in the Brief Hospitalization Unit. Including those
admitted more than 2 times. Collecting these variables; number of
readmissions, age, sex, employment status, diagnosis, family sup-
port, housing, therapeutic compliance and substance abuse.
Results.– We obtained the following data: There were 380 admis-
sions, 68 of them were re-admissions. 43 patients re-admitted
twice and eleven patients three or more times. We selected the Figure 1. Results for yearly mean employment rate per diagnoses
eleven patients with three or more admissions, assuming a total of and onset age groups.
36 admissions. Three people had four incomes and eight, three. Four
women and seven men. Ages between 24 and 60 years. Only two Conclusions.– Early onset mental illness hinders education and
were working. Diagnoses: Bipolar disorder, BPD, Schizoaffective results in poorer employment especially in psychotic disorders.
and cognitive impairment. Five without family support. Five home- Disclosure of interest.– The authors have not supplied a conflict of
less. Five with good therapeutic compliance. Eight with substance interest statement.
abuse.
Conclusions.– We did not find a common pattern in the different
E-PV0331
patients, being the most notorious the substance abuse. In future
studies we will increase the sample. Epidemiological profile of newly
Disclosure of interest.– The authors have not supplied a conflict of admitted psychotic patients in
interest statement. psychiatry
R. Jouini1* , M. EL Karoui2 , L. Robbana1 , S. Ben Ali3 , F. Ellouze1 , F.
Mrad1
E-PV0330 1 Razi Hospital, Psychiatry G Department, Tunis, Tunisia; 2 Razi
How does age at onset of mental Hospital, Psychiatry G DepartmentTu, Tunis, Tunisia; 3 Razi Hospital,
illness associate to later educational Psychaitry G Department, Tunis, Tunisia
and employment outcomes?
J. Immonen* , E. Jääskeläinen, T. Nordström, L. Ala-Mursula, N.
Background and aims.– Psychiatric hospitalization, when indicated,
Rautio, J. Miettunen
provides a safe environment for patients with acute mental distur-
University of Oulu, Center for Life Course Health Research, Oulu,
bance. This study aims to describe the epidemiological profile of
Finland
* Corresponding author. patients with schizophrenia and other psychotic disorders (DSM 5)
and to set up a comparison between their characteristics and the
Background and aims.– Mental illness often begins in the founda- rest of the patients.
tional years of education and may disrupt it. Later on, this can lead Methods.– A retrospective descriptive and comparative study
to social exclusion and unemployment. We investigated how age including all newly admitted patients (n = 240). We examined
at onset of mental illness affects the long-term educational and demographic and clinical characteristics and we established a com-
employment outcomes in prospective general population based parison based on the psychiatric diagnosis.
Northern Finland Birth Cohort 1966 (n = 11234).
Results.– The average age of patients with psychotic disorder was E-PV0333
34 years. The majority of patients with psychotic disorder were Paranoia and risk of personality
male (61, 6%), single (72, 1%) and unemployed (59,1%). The mean
disorder in the general population
duration of untreated illness was more important in patients with
J.E. Muñoz Negro1* , C. Prudent2 , J. Cervilla3
psychotic disorder. The mean duration between the onset of the ill- 1 Servicio Andaluz de Salud, UGC Salud Mental Hospital Universitario
ness and the hospitalization was more important in patients with
San Cecilio, Granada, Spain; 2 Université de Lorraine, Laboratoire
psychotic disorder. Hospitalization modality was in 93, 6% of the
INTERPSY, Nancy, France; 3 Universidad de Granada, Psiquiatría,
cases an involuntary confinement in patients with psychotic disor-
Granada, Spain
der. Physical restraint was used in 21, 1% of patients with psychotic * Corresponding author.
disorder and only in 8, 1% of the rest of the patients. Antipsychotics
were more prescribed in the group of patients with psychotic dis- Background and aims.– We hypothesized that paranoia is associated
order. The duration of parenteral treatment was longer in patients to personality disorder (PD) in the general population. The aim is
with psychotic disorder and the mean duration of hospitalization to explore this relationship between both entities.
was more important in the same group. Almost 85% of the psychotic Methods.– This was a population-based cross-sectional survey car-
patients attended the first follow up visit. ried out in Andalusia (Spain) using a representative sample of 4507
Conclusions.– Analyzing clinical and socio-demographic charac- participants. Paranoia was measured using the Green Paranoid
teristics of newly admitted patients enables the improvement of Thought Scale and risk of PD was screened using the Standard-
medical care and thus prognosis optimization. ized Assessment of Personality Abbreviated Scale whilst Borderline
Disclosure of interest.– The authors have not supplied a conflict of PD was measured with the CEPER-III Exploratory Interview of
interest statement. PD. Adjusted Pearsons’ correlations between paranoia and PD/BPD
were calculated.
Results.– Paranoia was associated with the risk of having PD and,
E-PV0332 more robustly, with BPD. Both associations held true when tested
The first thailand national survey on for both GPTS Paranoia subtypes (i.e., persecutory and reference)
prevalence of domestic violence for PD and for BPD and after accounting for the effects of age, sex
R. Kongsakon and child abuse.
Faculty of Medicine- Ramathibodi Hospital, Dep. of Psychiatry, Conclusions.– Paranoia seems to either augment the risk for, or be
Bangkok, Thailand part of, PD/BPD.
interest statement.
Objective.– The aim of the study was to assess the prevalence of
domestic violence at national level in Thailand and to identify some E-PV0334
major risk factors associated with the violence. Employment, unemployment and
Materials and methods.– A national cross-sectional survey was car-
mental health. A brief reflexion
ried out in 2017. A total of 2,280 households were drawn from
L. Niell Galmés1* , M.S. Hernandez Pignatta2 , Í. Alberdi-Páramo3 , G.
4 regions of Thailand using a stratified probability sampling. The
Montero Hernandez3
women were interviewed face-to-face without their family mem- 1 Hospital Universitario Infanta Sofía, Department of Psychiatry and
bers using a structured questionnaire developed by the researcher
Mental Health, San Sebastian de los Reyes, Spain; 2 Lateral Psicología,
team. The questionnaire included information on age, education,
Directora, Madrid, Spain; 3 Hospital Clínico San Carlos,
occupation, monthly family income, family size, smoking and alco-
Departamento de Psiquiatría y Salud Mental, Madrid, Spain
hol use, questions on the family experience of violence (physical * Corresponding author.
abuse, psychological abuse and sexual abuse), frequency of the vio-
lence, and problem solving. The questionnaire was checked in the Background and aims.– The consequences of employment and its
field before actual data collection. Data were analyzed statistically loss have been studied for years. The labor question transcends
by simple proportions and tests of significance. the mere economic sustenance, involving the subject in its total-
Results.– Total of 2,280 women from each selected households ity. Work involves, for example, imposing a temporary structure on
participated. The 787 of 2,280 women reported having domestic daily activity, extending the framework of interpersonal relation-
violence. The prevalence was 34.6%. Southern region showed the ships beyond the family context and linking the person to goals and
highest prevalence (48.1%). The women reported having physical objectives that transcend their own.
abuse in their family 32.3%, psychological abuse 9.9% and sexual Methods.– M. Jahoda (1) was possibly the first to theorize in a
abuse 4.5%. The factors associated with domestic violence included solid way about the psychic consequences of unemployment, not
regions (p < 0.001), living community (urban vs rural) (p < 0.001), only taking into account variables related to the loss of purchasing
income status (<0.001) and smoking or alcohol use (p < 0.001). power and the descent in the social elevator.
Conclusions.– This study emphasizes on the national survey. The Results.– Many studies have linked psychic discomfort, decreased
results can be the baseline data address the problem of domestic self-concept and self-esteem and even higher prevalence of symp-
violence. Domestic violence is related to the socioeconomic sta- toms and physical discomfort in periods of high unemployment,
tus, living community and smoking or alcohol use of the family interesting is, for the novelty, the study carried out by P. Eisenberg
members. and PF Lazarsfeld published in Psychological Bulletin (2) in 1938
Disclosure of interest.– The authors have not supplied a conflict of (coinciding with the Great Recession in the US) reaching results
interest statement. similar to those found in more recent periods of increased unem-
ployment.
Conclusions.– Even if there is strong scientific evidence about the
mental health consequences of unemployment, there are no actions
in standardized networks that work in line with these issues, which
are especially necessary in periods of economic recession.
(1) Jahoda M. Employment and unemployment: a socio-
psychological analysis Madrid: Morata, 1987
(2)Eisenberg P, Lazarsfeld PF. The Psychological effects of unem- patients with psychotic disorders (F20-F29), 42% of the total invol-
ployment. Psychological Bulletin. 1938; 3 5: 358-390 untary admissions. Althought only 30% of patients were admitted
Disclosure of interest.– The authors have not supplied a conflict of as a consequence of this disorder. The mood disorders (F30-F39)
interest statement. are 26% of the involuntary in-patient population. As a result of this
research we found that organic disorders (F70-F79) are the main
patients with involuntary admissions. The 80% of the people asso-
E-PV0335 ciated with these disorders are patients whom had a direct relation
Re-admission over four years in our with their legal status of incapacitated situation.
psychiatric units Conclusions.–
M.T. Perez Castellano1* , C. Romero Martin2 , P. Padilla Romero3 , G. Disclosure of interest.– The authors have not supplied a conflict of
Sanchez Amador1 interest statement.
1 Psychiatrist. Hospital Ntra, Sra. del Prado., Unit of Psychiatric
Hospitalization, Talavera de la Reina Toledo, Spain; 2 Hospital Ntra.

Sra. del Prado, Pharmacology, Talavera de la Reina Toledo, Spain; 3 E-PV0337
Hospital Ntra. Sra. del Prado, Psychiatry, Talavera de la Reina Toledo, Burnout and cognitive-affective
Spain empathy in health professionals in
monteria (Colombia)
E. Ruiz1 , A.M. Romero1 , M. Crespi2 , I. Ramos-Vidal3*
Background and aims.– In our Unit 35% of the patients are First time 1 Universidad Pontificia Bolivariana, Psychology, Monteria, Colombia;
admission and 65%Readmissions. It is vitally important to find out 2 Universidad de Buenos Aires, Psychology, Buenos Aires, Argentina; 3
the main qualities of our patients. The characteristics of the patients
University of Seville and Universidad Pontificia Bolivariana
will help to implement prevention plans for early detection and
Montería- Colombia, Department of Social Psychology, Seville, Spain
intervention in order to stop the readmission. * Corresponding author.
Methods.– Descriptive analysis of the patients characteristics dur-
ing their admission in the Unit. The study was done from 2014 to Background and aims.– The Burnout syndrome is considered one of
2017 and the categories that the study design were the discharge the psychosocial work harms with greater impact on the physical
of the patients, according to the criteria included in the CIE 10. and mental health. So it has become necessary to evaluate factors
Results.– A significance increase in the neurosis diagnose (F40- which may triggering this syndrome. On the other hand, empathy
F49) was founded along the years, the 35% of the new admissions. is defined as the ability of the clinician to put himself in the place
Although the Psychotic disorders (F20-F29) were the main cause for of the patient, considering himself as a valued medical attribute.
First time admissions, their tendency was to be stable and unchang- However, some studies indicate that it may also constitute a risk
ing during the four years; something very similar happened with factor for Burnout development. This study sought to determine the
the mood disorders (F30-F39). existence of Burnout syndrome in health professionals in the city
Conclusions.– The Psychotic and Mood disorders are the patients of Monteria and analyze their possible relationship with empathy.
with the highest number of admissions (75% of the Psicosis cases) Methods.– A quantitative cross-sectional and correlational study
what drived to conclusion that action plans were needed to be cre- was carried out in 201 general practitioners, with an equilibrate
ated with the purpose to stop the elevate number of readmissions distribution of men and women. The (a) Cognitive and Affective
in this group of patients. On the contrary 75% of organic disorders Empathy Test (TECA) was used to evaluate the emphaty dimen-
(F0-F09) are the First time admissions and the Neurotic disorders sion; and (b) the Maslach Burnout Inventory (MBI) was applied to
(F40-F49) had lower readmissions rate, in these case is necessary evaluate the Burnout syndrome.
to prevent and early diagnostic to avoid admissions. Results.– The results shows high levels of Burnout in the participants
Disclosure of interest.– The authors have not supplied a conflict of evaluated (66%) and the existence of a statistically significant neg-
interest statement. ative correlation between the variables of emotional exhaustion of
MBI and cognitive empathy (p < .01). The same tendency is observed
in the case of the depersonalization domain (p < .01).
E-PV0336 Conclusions.– The main conclusion of this preliminary study is
Involuntary admission to our that the lower the Empathy of the doctors evaluated, the greater
psychiatric units over four years (2014 the Burnout syndrome. Further research is needed to understand
to 2017) and disentangle the mediating mechanims between empathy and
M.T. Perez Castellano1* , P. Padilla Romero2 , C. Romero Martin3 , G. burnout in health proffesionals.
Sanchez Amador1 Disclosure of interest.– The authors have not supplied a conflict of
1 Psychiatrist. Hospital Ntra. Sra. del Prado., Unit of Psychiatric interest statement.
Hospitalization, Talavera de la Reina Toledo, Spain; 2 Hospital Ntra.
Sra. del Prado, Psychiatry, Talavera de la Reina Toledo, Spain; 3
E-PV0338
Hospital Ntra. Sra. del Prado, Farmacology, Talavera de la Reina
Toledo, Spain Suicides and mortality from
* Corresponding author. tuberculosis in Russia
Y. Razvodovsky1
Background and aims.– In Spain the Involuntary Psychiatric admis- Grodno State Medical University, Pathological Physiology, Grodno,
sion is regulated by Civil trial law 1/2000, 7th January, article 763. Belarus
Develop a study about involuntary admissions during the years * Corresponding author.
2014 to 2017. The aim of this research is to determine the effects
of the admissions in the patient’s pathologies. Background and aims.– Tuberculosis and suicide are related to the
Methods.– Descriptive research of patients divided into two groups; medical and social problems, and these epidemiological parame-
diagnosis categories and discharges (according to the criteria of ters are often considered as the indicators of psychosocial distress.
the CIE 10) with the purpose of compare and contrast the results There are theoretical assumptions and empirical evidence which
obtained. suggest the positive association between suicide and mortal-
Results.– The average of all involuntary admissions is 25’3% of the ity from tuberculosis at individual and population levels. Until
whole number of patients. The highest porcentage was found in recently, Russia was among the countries with the highest mortal-
ity rate from tuberculosis and suicide. In Russia, the risk of morbid- E-PV0340
ity and mortality of the population from tuberculosis increases with Employees’ knowledge, attitudes and
a decrease in the able-bodied part of the population, an outflow
intended behavior regarding
of investments from the region, deterioration in living conditions,
and a decrease in the level of employment of the population. The
coworkers with mental health
present study aims to assess the aggregate level link between the problems
mortality from tuberculosis and the suicide rates in Russia. G. Sampogna1* , E. Brouwers2 , C. Dewa3 , C. Henderson4 , J. Van
Methods.– Trends in age-adjusted sex-specific tuberculosis mortal- Weeghel2
1 University of Campania “Luigi Vanvitelli”, Department of Psychiatry,
ity and suicide (as an integral indicator for psychosocial distress)
rates from 1980 to 2015 were analyzed employing a time series Naples, Italy; 2 Tilburg University, Tilburg School of Social and
analysis in order to asses bivariate relationship between the time Behavioral Sciences- Department Tranzo- Tilburg University, Tilburg,
series. The Netherlands; 3 University of California, Department of Psychiatry
Results.– The results of analysis indicate the presence of a statis- and Behavioral Sciences, Sacramento, USA; 4 King’s College, Institute
tically significant association between tuberculosis mortality and of Psychiatry- Psychology and Neuroscience, London, United Kingdom
suicide rates for men at lag zero (r = 0,71:SE = 0,169). The association
between tuberculosis mortality and suicide rates for women was
Background and aims.– In many countries, participation of people
also positive, but statistically not significant (r = 0,26:SE = 0,169).
with mental health problems (MHP) in the workforce is problem-
Conclusions.– The results of this study suggest positive aggregate-
atic. Employees with MHP have a higher risk for sick leave, early
level association between tuberculosis mortality and suicide rates.
retirement, and unemployment than other workers. The extent to
This study indirectly supports the hypothesis that tuberculosis
which workplace stigma plays a role in this problem has been under
mortality can be considered as an indicator of psychosocial distress.
researched. The main aims of this work are: 1) How do employees
think about coworkers with MHP?; 2) What is their willingness to
interest statement.
spend time to support them?; 3) which variables explain the social
distance to coworkers with MHP in the workplace?
E-PV0339 Methods.– In February 2018, a cross-sectional survey was carried
out among a nationally representative internet panel of Dutch
The mental health risks of economic employees. A total of 1246 respondents filled out the question-
crisis in spain: evidence from primary naire (response rate 74,6%). Concepts measured were knowledge,
care centres, 2006, 2010 and 2017 attitude and (intended) behavior.
M. Roca1* , M. Gili2 , A. Seguí3 , A. Castro3 , M.Á. Pérez-Ara3 , M. Results.– A total of 39,9% preferred not to have a close colleague
Garcia-Toro1 , I. Ricci4 , A. Riera3 with MHP, and 61,2% preferred not to work for a manager MHP.
1 University of Balearic Islands, Department of Medicine, Palma de
The extent to which they were willing to spend extra time on a
Mallorca, Spain; 2 University of Balearic Islands, IUNICS-Idisba, coworker with MHP depended on whether they liked the coworker
Palma de Mallorca, Spain; 3 University of Balearic Islands, IUNICS (78,3% agreed). Main concerns were that the coworker could not
University of Balearic Islands, Palma de Mallorca, Spain; 4 Ib-Salut, handle work (44,7%), that the employee would have to take over
Gerencia de Atención Primaria Mallorca., Palma de Mallorca, Spain the coworkers’ work (32,9%), or would not know how to help the
coworker (37,6%). Factors that explain social distance will be pre-
sented at the conference.
Background and aims.– Spain was one of the countries most affected Conclusions.– Negative attitudes towards coworkers with MHP are
by economic crisis that began in 2007. We investigated the rela- highly prevalent. The present findings are relevant for future stud-
tionship between the frequency of mood, anxiety, somatoform, ies on sustainable employability of workers with MHE.
alcohol-related and eating disorders during the different stages of Disclosure of interest.– The authors have not supplied a conflict of
the economic crisis (2006, 2010, 2017) among population Span- interest statement.
ish primary care settings. The aim of the study was estimate the
changes of mental health in primary care before financial crisis,
during this period and at the current situation. E-PV0341
Methods.– Patients attending Spanish primary care centres were
Quality of life, chronic pain and
chosen randomly by physicians 7940 patients in 2006, 5876 were
selected in 2010 and 1090 in 2017. We used an own-elaborated medical conditions in different
questionnaire (data on demographic features, socio-economic and psychiatric disorders: a cluster
work- related variables and clinical characteristics), questionnaire analytic approach
of external stressful factors (Holmes and Rahe Scale) and a struc- M. Pacetti1 , R.P. Sant’angelo2* , M. Sanza2 , F. Ambrosini3
tured psychiatric interview for Primary Care (PRIME-MD) for the 1 Ausl Romagna, Mental Health, Forli, Italy; 2 Ausl Romagna, Mental
mental health diagnosis. Health, Cesena, Italy; 3 University of Bologna, Faculty of Psychology,
Results.– Compared with the pre-crisis period of 2006, the 2010 Cesena, Italy
survey revealed substantial and significant increases in the pro- * Corresponding author.
portion of patients with mood (19.4% in major depression), anxiety

(8.4% in generalized anxiety disorder), somatoform (7.3%), alcohol- Background and aims.– Psychiatric patients compared to healthy
related disorders (4.6% in alcohol dependence) and eating disorders controls tend to show a worse quality of life and worse medical con-
(0.15%). In the third wave (2017) the prevalence of mental health ditions. However, only few studies used a cluster analytic approach
disorders has decreased to similar rates before economic crisis. to stratify these aspects in a cross-diagnostic sample.
Conclusions.– Past global economic downturn seems to not have Our aim is to cluster a group of psychiatric patients based on a set
long effects on the mental health of the population. of variables concerning quality of life and other medical conditions.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– 27 patients (34.6%) with Borderline Personality disorder
interest statement. (BPD), 24 with Affective Disorders (AD,30.8%) and 27 with Psychosis
(P,34.6%) were recruited. A two-step cluster analysis was conducted
based on: drug and anti-inflammatory abuse, sexually transmitted
diseases, voluntary termination of pregnancy, parasuicidal behav-
iors, suicide attempts, fractures; BMI; chronic pain and internal
medicine comorbidities; scores to SCOFF, TWEAK, WHOQoL; scores E-PV0343

to a VAS about the experience of physical pain. Demographics, clinical
Results.– Two clusters were obtained. Cluster 1 (C1) (31 subjects,
characterization, and length of
39.7%) and Cluster 2 (C2) (47 individuals, 60.3%) differed mostly on
WHOQoL, severity of pain experienced, occurrence of fractures and
hospitalization of patients admitted
score to the SCOFF test. A MANOVA confirmed that C2 has better to general psychiatry unit of
quality of life, whereas chi-squared tests confirmed that C1 tend to multidisciplinary province hospital in
show more frequently anti-inflammatory abuse, severe pain, frac- tarnowskie góry, Poland in 2017.
tures and higher scores to SCOFF. Interestingly, the clusters differed A.R. Szczegielniak1,2* , P. Ścisło2 , M. Błachut2,3 , P. Gorczyca2,3
in diagnosis (p = .000), with BPD individuals over-represented in C1. 1 Medical University of Silesia, Department of Psychiatry and
Conclusions.– The detection of groups with similar internal medical Psychotherapy- School of Medicine in Katowice, Katowice, Poland; 2
conditions and quality of life can be useful to tailor specific inter- Multidisciplinary District Hospital, General Psychiatry Unit,
ventions on psychiatric patients. Attention must be paid to BPD as Tarnowskie Góry, Poland; 3 Medical University of Silesia, Department
it seems to be highly vulnerable on these aspects. of Psychiatry in Tarnowskie Góry- School of Medicine with the
Disclosure of interest.– The authors have not supplied a conflict of Division of Dentistry in Zabrze, Katowice, Poland
Background and aims.– Mental healthcare across European region

E-PV0342 is very diverse in terms of availability of treatment, models of psy-
Organizational and methodological chiatric care, and ways of professional training. Thus, in the light
work in the practice of psychiatric of challenges that modern psychiatry faces resulting from high
outpatient consultative reception levels of mental disorders, limited financial resources, insufficient
L. Shapovalova1* , K. Shapovalov2 facilities for people suffering from mental health outside hospitals
1 State Autonomous Health Agency of the Republic of Komi and deep-rooted stigma surrounding psychiatric treatment, regu-
“Consultative and Diagnostic Center of the Republic of Komi”, lar assessment of patients’ profile is vital. Polish psychiatry requires
Consultative department, Syktyvkar, Russia; 2 State Education urgent systemic and mental changes, while the demand for psychi-
Agency of Additional Professional Education of Republic of Komi atric treatment in the country is growing. The aim of this research is
“Komi Republican Institute for Development of Education”, Chair of to describe the clinical and demographic characteristics of patients
Additional Education, Syktyvkar, Russia referred to a General Psychiatric Units of Multidisciplinary Province
* Corresponding author. Hospital in Tarnowskie Góry, Poland over a one year period (2017)
to describe a profile of patients visiting the facility with insight into
Background and aims.– Organizational and methodical work is a interlinkages between given diagnoses, length of stay, prescribed
mandatory section of psychiatric outpatient consultative reception medications, available reimbursement of medical expenditures.
Methods.– Normative, analytical. Methods.– Retrospective data from the patients’ records was
Results.– Psychiatr of consultative department was approached extracted and modalities analyzed.
6255 people in 2015-17, of them primary ones were 4,027 (64.38% Results.– This is a first phase of a multicenter study that would
of the total number taken). Currently, outpatient psychiatrist works focus on characterization of patients admitted to general psychi-
in accordance with thirty-eight standards, twelve clinical recom- atry departments across Europe, gathering data from Hospitals in
mendations, a large number of normative and legal documents. Poland, Turkey, Romania, Albania, Ireland, Spain and Portugal to
Conclusions.– Organizational and methodical work of practical define demographics, characterize profile of the patients and define
physician is important part of his activities to protect and pro- common trends in treatment.
mote public health, improve the quality of life, prevent and treat Conclusions.– A better understanding of patients’ needs can be the
diseases. Psychiatrist’s analysis of medical, organizational, method- basis for effective initiatives related to the prevention of mental
ological and socio-hygienic effectiveness of his own professional illness and the improvement of the structure of existing healthcare
activity, department and institution as whole, provides effective facilities.
monitoring for making prompt and timely management decisions. Disclosure of interest.– The authors have not supplied a conflict of
Significant volume of regulatory documents on implementation interest statement.
of practical medical activities and standards for specific diseases,
clear framework for diagnostic and therapeutic actions limits clini-
cal thinking and application of professional experience of practical E-PV0344
doctor. This phenomenon can be regarded as an undesirable effect Psychiatric disorders among patients
of strict regulations and standardization of professional actions of with multiple sclerosis in Poland
psychiatrist of consultative reception in diagnosis and treatment A.R. Szczegielniak1,2* , M. Zajac
˛ 2 , K. Swierzy2 , M. Błachut2,3 , K.
of the pathology of the mental sphere of patients who are being ˛
Kubicka-Baczyk 4 , M. Adamczyk-Sowa4 , P. Gorczyca2,3
treated. Implementation of regulatory documents in health care is 1 Medical University of Silesia, Department of Psychiatry and
form of professional protection for doctor of any specialty, includ- Psychotherapy- School of Medicine in Katowice, Katowice, Poland; 2
ing psychiatrist, both on the part of inspecting corporate medical Multidisciplinary District Hospital, General Psychiatry, Tarnowskie
associations and organizations, and supervisory control bodies. Par- Góry, Poland; 3 Medical University of Silesia, Department of
ticipation of psychiatrist in system of continuous medical education Psychiatry in Tarnowskie Góry- School of Medicine with the Division
is promising step in its integration into international European and of Dentistry in Zabrze, Katowice, Poland; 4 Medical University of
world accreditation systems. Silesia, Department and Clinic of Neurology- School of Medicine with
Disclosure of interest.– The authors have not supplied a conflict of the Division of Dentistry in Zabrze, Katowice, Poland
Background and aims.– Multiple Sclerosis (MS) is one of the most

common cause of a nontraumatic neurologic disability worldwide,
especially among young adults. Mental health challenges signif-
icantly affect the quality of life of patients in addition to the
neurological burden of MS. Epidemiological data on the occurence
of mental disorders in MS patients in Poland is deficient, and the E-PV0346

results of other studies globally are divergent. The aim of the study Parkinson’s disease and psychiatric
was to determine prevalence of mental disorders in a sample of
comorbidity: a register-generated
Polish MS patients.
Methods.– The study took place in 2017–2018 and consisted of
nationwide cohort
103 MS patients treated in the Neurological Outpatient Clinic C.C. Vasarhelyi
of the Medical University of Silesia Hospital No. 1 in Zabrze, University of Southern Denmark, Fokuseret Forskningsenhed
Poland. Data on sociodemographics, type and course of the under- Aabenraa, Odense, Denmark
lying disease, comorbidities and used medicines were collected.
MINI-international neuropsychiatric interview and psychiatric Background and aims.– Parkinsonian diseases are still today incur-
examination were utilized to assess the occurrence of mental disable degenerative diseases of the brain, and a reality for millions.
orders. With no curing treatment, extra effort should be made to treat
Results.– All the patients were examined by a qualified psychia- symptoms and comorbidities. These individuals are estimated to
trist. Among them 68% presented psychiatric diagnosis at some be at an increased risk for psychiatric disease, but little mapping of
point in their life with only 4% hospitalized before; 49,5% met diag- psychiatric comorbidity exists.
nostic criteria of different psychiatric disorders (8,7% depressive The Aim of this study: To determine prevalence and onset of psy-
episode; 6,7% anxiety disorder; 36,8% other disorders including chiatric comorbidity in patients suffering from Parkinsons Disease
mixed anxiety and depressive disorder), and 17,5% presented cog- or Atypical Parkinson syndrome, before and after time of diagnosis.
nitive disorders. 6,8% of all patients had at the time of the study Methods.– This is a cohort study using the Danish National Patient
suicidal thoughts (including 4 people with a high risk of suicidal Registry and the Danish Psychiatric Central Register. The patient
attempt according to MINI). group is compared to a control group of people matched on age
Conclusions.– Significant prevalence of mental disorders among MS and sex, in the number of 10 controls to 1 case. Inclusion criteria:
patients has been confirmed however further studies should be Parkinson or Atypical Parkinson Syndrome patients younger than
continued as presented results may reflect several factors. 65 years are all included. Patients must have their diagnosis for 5
Disclosure of interest.– The authors have not supplied a conflict of years, to minimize the risk of misdiagnosis. The psychiatric diseases
interest statement. are grouped in the ICD-categories F1, F2, F3, F4 and F6; relating to
substance abuse, schizophrenia spectrum disorders, mood affective
disorders, anxiety related disorders and disorders of personality
E-PV0345
and behavior, respectively.
Understanding the mechanisms Results.– The results are under conduction.
through which early sleep problems Conclusions.– Perspective: We expect to find higher rates of psy-
impact later cognitive human capital chiatric diseases in Parkinsonian patients compared to the general
N. Varghese1 population.
Bocconi University, CERGAS, Milano, Italy Disclosure of interest.– The authors have not supplied a conflict of
Background and aims.– Previous literature finds negative impact of

poor sleep quantity and quality on cognition. In this study, we begin E-PV0347
with looking at the impact of sleep quality on cognitive skills in First episode psychosis in
children and finally understanding the role of non-cognitive skills,
schizophrenia: internalized stigma
specifically behavioural difficulties in explaining this effect.
Methods.– We use ALSPAC data from UK for this study. Sleep quality and social adjustment. study on a
is measured from 18 to 108 months of age and the cognitive skills number of patients of the omsk
are analysed at 5, 7, 8 and 9 years of age. Using regression analy- region (Russia)
sis, we estimate the critical age and sensitive periods at which sleep K. Vasilchenko* , Y. Drozdovsky
quality has an effect on cognition. For understanding the mediating Omsk State Medical University, Department of Psychiatry and
effect of behavioural difficulties, we employ Oaxaca decomposition Medical Psychology, Omsk, Russia
analysis that explains the difference in the means of the cogni- * Corresponding author.
tive skills between children who sleep well and who do not due
to differences in mean values of behavioural difficulties. Background and aims.– The issue of treating patients with a first-
Results.– We find that there is a negative, dose-response effect of episode psychosis in schizophrenia (FEPS) remains highly relevant.
poor sleep quality on cognition. This effect is stronger for children To sustain a proper level of social functioning, the rehabilitation
of mothers with high prenatal depression and one-third of the neg- measures are needed to be implemented at the early stages of the
ative effect of poor sleep quality on cognition skills are explained disease, when psychopathological processes retain their plasticity.
by behavioural difficulties. The number of studies of internalized stigma (IS) in patients with
Conclusions.– This study stresses on the importance of better qual- FEPS for the purposes of their social and clinical adjustment has
ity sleep of child in the early stages of life for later cognition. We been limited.
understand that it is not completely the exposure to poor sleep that Objective.– to study the specificity for patient adjustment with FEPS,
impacts cognition but also the behavioural difficulties, an outcome taking into consideration the IS-level for the follow-on elaboration
of poor sleep. Moreover policies to improve cognitive outcomes in of rehabilitation programs.
children should begin from mother’s pregnancy for better results. Methods.– The sample consisted of patients with FEPS (n = 134).
Disclosure of interest.– The authors have not supplied a conflict of The diagnosis of schizophrenia was established based on the cri-
interest statement. teria of the ICD-10. Adjustment of patients summing up of one
of 7 levels of social and clinical adaptation was investigated. The
levels 1 to 4 were considered as compensated, and 5 to 7 were
decompensated. The ISMI scale has been used as a measure of IS.
To explore the distribution of values of the quantitative variables
Kolmogorov-Smirnov and Shapiro-Wilk tests have been used.
Results.– All the patients corresponding to four types of adjustment Methods.– The patient’s assessment did not present any major psy-
were distributed into 4 groups: integrative (n = 112), destructive chopathology, or a previous psychiatric history. A Mini Mental State
(n = 6), extravert (n = 6) and introvert (n = 10). The highest level of Evaluation (MMSE) test was performed in which she scored 30. She
IS was detected in destructive and introvert groups in comparison was referred to the Internal Medicine Department.
with others (p < 0.01). Results.– The laboratory tests and the imaging assessments revealed
Conclusions.– The interrelation of IS and social adjustment is signif- a primary tumor of the left lung with esophageal and pericardial
icantly higher than the interrelation of IS and clinical adjustment. infiltrations, as well as two metastatic tumors of cerebellum. Dur-
The data obtained allowed to develop new rehabilitation programs ing the patient’s admission, we were asked to assess her condition
for patients with FEPS based on the organization of destigma mea- many times, due to her refusal for further painful examinations
sures. and treatment by the doctors. She did not present any major
Disclosure of interest.– The authors have not supplied a conflict of psychopathology, or cognitive impairments. She wished to be dis-
interest statement. charged and die at home.
Conclusions.– As psychiatrists, it is crucial to distinguish symptoms
of grief and depression in terminally ill patients, in order to make
E-PV0348 the correct intervention. As doctors, however, we must ask our-
Renaming schizoprenia in Russia. Will selves, where lies the fine line between arrogance and respect to
it destigmatize? a study on sample of another human being’s will?
medical students
interest statement.
K. Vasilchenko* , V. Ismagilova, Y. Drozdovsky
Omsk State Medical University, Psychiatry and medical psychology,
Omsk, Russia
E-PV0350
Assisted suicide for psychiatric
Background and aims.– To determine the perception of the term patients: current status in switzerland
schizophrenia among medical university students. S. De Lucia1* , G. Bondolfi1 , E. Girard1 , C. Marti2 , O. Boillat2 , S.
Methods.– The cross-sectional study was performed in October Hurst3
2018 with a sample of 164 medical students from Omsk State 1 Liaison Psychiatry SPLIC- Geneva University Hospital, Psychiatry
medical University (Omsk, Russia). One of three patient histories DSMP, Geneva, Switzerland; 2 Internal Medicine SMIG- Geneva
was shown to students randomly before participants started to fill University Hospital, Internal medicine- geriatrics and rehabilitation
the questionnaire form. The questionnaires were administered in DMIRG, Geneva, Switzerland; 3 Université de Genève, Institut
a class environment. Ethique- Histoire- Humanités, Geneva, Switzerland
Results.– There were no statistically significant differences deter- * Corresponding author.
mined between the forms differed only in diagnosis term (p = 0,91).

The Kruskal-Wallis test was used to compare statements. No Background and aims.– In most European countries assisted sui-
statistically significant difference was found between all of the cide is not legal. Switzerland, uniquely, allows suicide assistance
statements (p > 0,05). by non-physicians. Long considered exclusively for terminally ill
Conclusions.– There was no difference determined between med- patients, suicide assistance is increasingly considered for chron-
ical students’ attitudes toward three different terms of diagnoses. ically ill patients, including those suffering from moral distress
Nevertheless, the limitations of the study should be considered. related to a mental condition. Up to 3% of assisted suicide have
Thus, stigma of schizophrenia in a population’s mind is suggested been performed for psychological suffering.
not to depend on a name of the illness but on another factors that To discuss legal and ethical issues in providing assisted suicide to
are needed to be investigated in further studies. psychiatric patients.
Disclosure of interest.– The authors have not supplied a conflict of Methods.– We report the case of an older patient who was admit-
interest statement. ted to our hospital with a stuporous state after having ingested
phenobarbital. A letter from her GP was found, stating that the
patient was in such a psychological distress that the GP supported
the patient’s project to kill herself. Based on this situation we dis-
E-Poster Viewing - 7–9 April: Ethics and Psychiatry cuss the legal and ethical issues raised by patients who ask their
doctors to provide them with suicide assistance for psychological
suffering.
E-PV0349 Results.– Assisted suicide for psychiatric patients –with or with-
out somatic comorbidities-is legal in Switzerland provided that
Involuntary psychiatric commitment
the patient is competent and the doctor providing assistance has
in a terminally ill patient: a case report no self-serving purpose. Case law has confirmed that a blanket
P. Argitis1* , C.M. Platsa1 , S. Karavia1 , A. Kourti1 , L. Gkeldis1 , P. exclusion of psychiatric patients from suicide assistance would
Bouras2 , K. Gatsiou1 , P. Portokalakis1 , Z. Chaviaras1 constitute discrimination. However, providing such assistance
1 General Hospital of Corfu, Psychiatric, Corfu, Greece; 2 General
requires a psychiatric evaluation and failure (or competent refusal)
Hospital of Corfu, Internal Medicine, Corfu, Greece of all available alternatives.
Conclusions.– Psychological suffering is very common and can
Background and aims.– Terminally ill, with advanced cancer, lead people to ask for assisted suicide. There are various policies
patients experience a lot of distress, as a result of their disease and and laws about this topic in European countries. In our opinion,
preparatory grief. We present a case of a 53-year-old woman, that Switzerland is a good example of a country which has made efforts
was transferred to the Psychiatric Department of the General Hos- in this purpose.
pital of Corfu through a Public Prosecutor’s request, with a refusal Disclosure of interest.– The authors have not supplied a conflict of
of nutrition. interest statement.
E-PV0351 done. Due to characteristics of the lesion and the chronological

Ethical challenges for relationship with the psychotic symptoms, surgery was proposed;
however, the patient refused it as part of her persecutory delu-
psychiatrist/psychotherapist caring
sion, denying the tumor presence. Due to the lack of insight for the
for suicidal patients disease or need of treatment, and following the beneficence princi-
G. Dedic ple, surgery was pondered. The ethics committee was consulted, as
Military Medical Academy, Clinic for psychiatry, Belgrade, Serbia the autonomy principle was compromised since psychotic symp-
toms distorted the appreciation of the disease and the autonomy
Background and aims.– To any psychiatrist/psychotherapist, no of thought when making her decisions. Because of increasing
matter how responsible, successful and skillful he is, could be psychotic symptoms and agitation, compulsive admission on a
happened that his patient commits suicide. There is considerable psy-chiatric ward was considered prior to the surgery. When
uncertainty about how to resolve ethical issues when caring for informed of this hypothesis, the patient agreed to the
suicidal patient. neurosurgical treat-ment.
Methods.– The presentation will consider the following questions: Conclusions.– Although the dilemma has been resolved sponta-
Is suicide allowed or prohibited? Does one person have the right to neously, it is worth reviewing this case and ethical principles
commit suicide? Should anyone try to prevent a person who wants involved in light of relevance to clinical practice.
to commit suicide? Is a person accountable and able to manage his Disclosure of interest.– The authors have not supplied a conflict of
actions in order to be responsible for committing suicide? Even if interest statement.
suicide is allowed, does it affect the moral values of one person (or
society)? Assuming that one person is allowed to commit suicide,
is it allowed to help another person to end his/her life? Giving pub-
licity to suicide can create the idea that the choice of such behavior
is normal?
Results.– Caring for suicidal patients is clinically and ethically chal-
lenging. A psychiatrist/psychotherapist working with his suicidal
patient should recognize the suicidal ideas, assess suicide risk, and
administer and apply the treatment plan for a suicidal patient, and
if necessary, to hospitalize him (willingly or unwillingly).
Conclusions.– Assessment of suicidal risk in undertaking patient
protection procedures as well as respect of ethical / legal issues
in psychiatry is necessary. Good clinical practice, without the ther-
apist’s fear of being charged, should be decisive in his decision to
forcibly hospitalize a suicide patient. In suicide reporting in media
emphasis is not on censorship, but on recognizing the suicide risk
factors and in suicide prevention.
interest statement.
E-PV0352
Meningioma related psychosis - an
ethical reflection on therapeutic
decision
T. Ferreira1* , F. Godinho2 , L. Ferreira3 , A. Luís1 , T. Maia1
1 Hospital Prof. Doutor Fernando da Fonseca, Department of
Psychiatry, Amadora, Portugal; 2 Hospital do Espírito Santo,
Department of Psychiatry, Évora, Portugal; 3 Hospital Distrital de
Santarém, Department of Psychiatry, Santarém, Portugal
Background and aims.– Neuropsychiatric manifestations of central

nervous system tumors are common. Although tumor removal can
resolve this symptomatology, offering treatment may be impossi-
ble when there’s lack of insight, such as when psychotic symptoms
are present. Our aim was to develop an ethical reflection about a
clinical case.
Results.– A 40-year-old female with no previous psychiatric his-
tory was taken to the emergency department due to psychomotor
agitation. In the initial evaluation, persecutory delusions and two
previous episodes of seizures were detected. Head Computed
Tomography revealed an expansive bilateral frontal lesion sugges-
tive of meningioma, confirmed by Magnetic Resonance Imaging.
Psychotic symptomatology responded inconspicuously to risperi-
E-PV0354 years. The group with academic education has more knowledge
The role of ethics in global mental than those without it (71% versus 33.8%, p < 0.001, 2 : 11.64)
There are no differences according to gender or professional cate-
health
gory.
S.O. Okpaku
Conclusions.– Knowledge of the general principles of bioethics in
Center for Health- Culture and Society, Center for Health- Culture and
the health professionals in our study is insufficient. Less than 50%
Society, Nashville, USA
* Corresponding author. of respondents know of any principle of beginner bioethics. The
importance of university academic education should encourage the
Background and aims.– Aim: Exploration of essential ethical issues strengthening of curricular formation
in foreign aid projects & global mental health. Disclosure of interest.– The authors have not supplied a conflict of
Global Mental Health implies a bilateral or multilateral engage- interest statement.
ment usually between a donor (from a developed country) and a
recipient organization or institution from a developing country.
These relationships are often asymmetrical as the donor insti- E-Poster Viewing - 7–9 April: Forensic Psychiatry
tutions country the purse strings. In 2005 the Organization for
Economic Cooperation and Development enacted a declaration
aimed at accountability e.g. developed and developing countries E-PV0356
for developing and managing and in terms of 5 principles. In 2013
Huntington’s disease or
John Sopko suggested a template of seven questions that are criti-
cal in the planning and evaluative plan of reconstruction. Although schizophrenia– does it really matter?
he was referring specifically to Afghanistan, this template may also /in forensic evaluations/
apply to other foreign and projects. Okpaku on defining the crite- D. Bosnjak Kuharic1* , N. Buzina2 , G. Arbanas2
1 University Psychiatric Hospital Vrapce, Department for Diagnostics
ria for global mental health emphasized the need for the recipient
countries to the problem. This presentation will explore the ethi- and Intensive Care, Zagreb, Croatia; 2 University Psychiatric Hospital
cal issues of foreign and projects and discuss the implications for Vrapce, Department for Forensic Psychiatry, Zagreb, Croatia
research and practice. The presentation will expose the limitation
of what may initially be seen as a war on war situation.
Methods.– Literature review. Background and aims.– Huntington’s disease (HD) is a neurodegen-
Results.– Identification of ethical issues in foreign aid projects. erative disease characterized by motor, psychiatric and cognitive
Conclusions.– A consideration of ethical issues in foreign aid projects symptoms. Although the main criteria for HD diagnosis include
is critical. The opportunities for improvement in this field of activ- positive genetic test and involuntary choreiform movements, “pre-
ity. motor” symptoms like depression, psychosis, impulsivity, hostility
Disclosure of interest.– The authors have not supplied a conflict of or cognitive impairment can present years or even decades before
interest statement. the motor abnormalities. Our aim was to discuss potential differen-
tial diagnosis in the case of a forensic patient previously diagnosed
with schizophrenia who developed HD with progressive cognitive
E-PV0355 decline later-on.
Methods.– We present relevant clinical data including history, psy-
Knowledge of the fundamental
chiatric evaluation and complete diagnostic work-up.
principles of bioethics among Results.– A 50-year-old male patient diagnosed and treated for
healthcare professionals paranoid schizophrenia since 2012 was admitted to the Foren-
B.O. Plasencia García De Diego1* , S.L. Romero Guillena2 , F. Gotor sics department after he was assessed not guilty for the reason of
Sanchez-Luengo3 , O. Santamaría Gómez3 , R. Navarro Pablo3 insanity for murder attempt of a passer-by in 2017 due to acute psy-
1 Hospital de la Merced, Psychiatry, OSUNA, Spain; 2 Hospital
chosis. During 8 months of hospital treatment his state has worsen
Universitario Virgen de la Macarena, Psychiatry, Sevilla, Spain; 3 rapidly with disorganized behavior, visual hallucinations, cognitive
Hospital Nuestra Señora de Valme, Psychiatry, Sevilla, Spain deterioration, weight loss, inability to control sphincters or to take
care of himself. Due to these specific symptoms and positive psychi-
atric heredity for both schizophrenia and dementia, a wide range
Background and aims.– Bioethics is born with the intention of
of diagnostic work-up was done revealing CAG triplets and positive
becoming a guide for action, such as using knowledge for the good
genotype with CAG-expanded allele gene characteristic for HD.
and the future of the human condition.
Conclusions.– Although the patient fulfilled diagnostic criteria for
Objectives.– Analyse the knowledge of healthcare professionals in
schizophrenia confirmed by multiple psychiatrists and forensic
the basic principles of bioethics.
evaluation, later course of illness questions the nature of his psy-
Methods.– Observational study carried out through an anonymous
chotic decompensations: were they relapses of schizophrenia or
survey of health professionals (Medicine and Nursing).
early, non-specific representations of HD? But, whatever the case,
The survey collects socio-demographic variables: age, gender and
the forensic evaluation of his criminal responsibility would be the
professional category; questions related to knowledge and training
same.
in bioethics.
Results.– 96 subjects (44 men and 52 women). 63 doctors and 33
interest statement.
nurses. Average age of 46.31 years (D. S. 10.6).
Knowledge of the principles of bioethics:
*45.8% of the sample knows some principle of bioethics; the E-PV0357
most mentioned is that of charity (39.6%), non-deficiency (33.3%),
Clinical and criminological features of
autonomy (24%) and justice (17.7%).
*A 13.5%, knows the 4 principles those referred to the new italian
*Age. <45 years old, has a higher level of knowledge vs. >45 years forensic services: suitable or unfit?
(60% versus 33.3%, p < 0.001, 2 : 6.84). L. Castelletti1* , F. Scarpa2
1 AULSS 9 “Scaligera”- SSR Veneto, REMS del Veneto, Nogara, Italy; 2
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EDITORIAL LEADERSHIP

President: S. Galderisi (Naples)

Subscribe to European Psychiatry

Imprimé en France par Jouve, 53101 Mayenne.

Abstracts of the 27th European Congress of Psychiatry - 2019

Contents lists available at ScienceDirect

Contents lists available at ScienceDirect

E-Poster Presentation: Anxiety Disorders and E-PP0002

E-PP0003 a psychiatric disorder after been presented in Primary care depart-

Often associated with a sense of impending doom, these symptoms E-PP0011

E-PP0016 not subside with prescribed pharmacological treatment. After the

Background and aims.– Biases in information processing play an

sia, although she still continued puerile. She continued treatment

E-PP0034 Hospital Vrapce during 2017 and 2018. Examination included

E-PP0037 Background and aims.– Improving the pharmacotherapy of epilepsy

E-PP0043 nephrogenic diabetes insipidus (DI). While PP is primarily char-

E-PP0049 Methods.– Ethnological, clinical-epidemiological and statistical

a depressant effect on central nervous system, and act as well E-PP0057

demographics, work position details, experience with ASD stu- E-PP0060

E-PP0065 Results.– There is a relationship between ASD and AN (20–25%).

mood elevation in bipolar patients without PD. DRT may also be

E-PP0081 bipolar patients. Antipsychotic drugs associated to mood stabilizers

Background and aims.– Traditionally alcohol has been used by the

Department of Psychiatry, Bengaluru, India; 3 All India Institute of E-PP0096

Background and aims.– Ayahuasca, also called yagé, is a psy-

E-PP0104 Background and aims.– In bipolar disorder, impairment in both cog-

Conclusions.– Laboratory monitoring is crucial for successful detox. E-PP0108

harm. Suicidal ideation includes suicidal thoughts and plans.

Background and aims.– History of childhood trauma (HCT) is asso-

tive episodes (p = 0.034 and p = 0.005) and lithium-treated patients

Background and aims.– According to international guidelines,

Pamplona, Spain; 3 Rioja Salud, Psychiatry, Logroño, Spain; 4 Pennine

E-PP0131 feasibility, acceptability and efﬁcacy of a CBT treatment programme

UR12SP20 and Faculty of Medecine of Tunis, Tunis, Tunisia; 2 E-PP0137

Conclusions.– In addition to describing the study design and initial

Background and aims.– The integrative program in place in public

ment I’s dimension corresponded to the lower score (62.2 ± 25.3).

Methods.– Retrospective analysis of clinical records of patients who E-PP0147

Results.– Prevalence rates of child mental disorders are up in Mexico E-PP0150

Background and aims.– Early detection of speech children with

Background and aims.– Hyperprolactinemia is a common adverse

First Department of Pediatrics- Athens University Medical School-

Background and aims.– The “House of the Child” (HoC) is a ther-

Methods.– Children which have survived child abuse or neglect E-PP0162

days. Memory was assessed with experimental pathopsychological E-PP0165

Background and aims.– To determine the risk of morbidity and suici-

Background and aims.– Recent years have seen an increase in clin-

E-PP0182 fore, the delinquent behavior of the sub-experts can be viewed

E-PP0188 symptoms was determined by scores on the Korean ADHD Rating

to 7 years with autism spectrum disorders were examined (clinical- E-PP0196

Conclusions.– The proposed treatment complex with the lowest

- with affective and behavioural disturbances. Formation of the

Table 1. Psychiatric comorbidity in adolescents with gastroe-

than 1 year by using stratiﬁed propionate sampling technique. Stu- E-PP0214

Trauma, Radiology, Moscow, Russia; 2 Psychiatry- National Mental

ICD-10) and 15 mentally healthy age- and sex-matched subjects E-PP0220

Background and aims.– DBT is effective for borderline personality

• Qualitative feedback using questionnaire followed by thematic E-PP0223