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Membrane 37-Kda Islet Beta Cell Antigen: Pancreatic Autoimmune Disorders: Edt
Membrane 37-Kda Islet Beta Cell Antigen: Pancreatic Autoimmune Disorders: Edt
PITUITARY GLAND
SHEEHAN’S SYNDROME
- Lymphocytic adenohypophysitis
- Rapid decline in pituitary function
- Often in postpartum women
- Autoantibodies against pituitary cells
- Distinguished by a mononuclear infiltrate of the
pituitary and hypophysis
PARATHYROID GLAND
IDIOPATHIC HYPOPARATHYROIDISM
- Childhood disorder in type 1 polyglandular
syndrome
- Associated with complement-mediated
cytotoxicity of parathyroid cells
- Autoantibodies against endothelial cell proteins
and mitochondria
POLYGLANDULAR SYNDROMES
Type 1
- Mucocutaneous candidiasis
- Associated endocrinopathies during early
childhood
- 50% of patients develop Addison’s disease
- Manifests gonadal failure, alopecia, and
chronic hepatitis
- Has organ-specific autoantibodies
- Poorly defined defects in cell-mediated
immunity
Type 2
- AKA Schmidt’s syndrome
- Combined occurrence of IDDM/ autoimmune
thyroid disease with Addison’s disease
- Primarily in women in the 2nd/3rd decade of life
- Familial
- Genetically associated with: HLA-DR3
Type 3
- AI thyroid disease with 2 other AI disorders such
as:
o IDDM