CHAPTER-7

SUMMARY
SUMMARY

 In the present work, an effort was made to formulate and evaluate fast dissolving

tablets of Montelukast Sodium and it’s bioavailability study using polymers such as

SSG, Crospovidone, guar gum, Gellan gum, sterculia gum

 From the past two decades there is an enhanced demand for more patient compliance

dosage forms. As a result, the demands for the technologies are increasing three folds

annually. Since the developing cost of new chemical or drug is very high. For

developing of fast dissolving tablets which improve efficacy, safety and better

bioavailability together with reduced dose frequency to minimize side effects.

 Montelukast Sodium is white colour powder which comes under BCS-II. Melting

point of Montelukast Sodium was found to be 108-110 ˚C. It is soluble in water,

ethanol and dimethyl formamide. FT-IR spectrum obtained for drug with formulation

excipients showed characteristic peaks of the drug at their respective wavelength with

no major shifts indicating chemical integrity of drug. Fast dissolving tablets of

Monteuikast Sodium were prepared by direct compression using different

concentration of ratios such as F1-F18. Formulations were subjected to the pre-

compression and post compression parameters were found to be within standard limit.

 The drug release was found to better with combination of both crospovidone and

gellan gum polymers in formulation F9. Model equation of Zero and first order,

Higuchi and Peppas intended to elucidate the drug release mechanism and were fitted

to release data. Mathematical modeling of in-vitro dissolution data indicated the best

fit release kinetics was achieved first order kinetics. The F9 selected best formulation

Department of Pharmaceutics, Mallige college of pharmacy, Bangalore Page 125

 CHAPTER-7
SUMMARY
among all twelve formulations. The kinetics of drug release was best explained by

first order indicating concentration dependent.

 The stability studies revealed the satisfactory physical and chemical stability of the

formulations.

Department of Pharmaceutics, Mallige college of pharmacy, Bangalore Page 126