CHAPTER-7 CONCLUSION

CONCLUSION

Fast dissolving tablets of Montelukast Sodium were successfully prepared to treat the

Asthma. Fast dissolving tablets were prepared by direct compression method. The

following conclusions can be drawn from the results obtained.

 Compatibility of the pure drug (Montelukast Sodium) with polymers and other excipients

was confirmed by FTIR studies.

 The Pre-compression parameters like Bulk density, Tapped density, Angle of repose,

Hausner’s ratio and Carr’s index of all formulations were found to be within the standard

limits.

 The evaluation data for post-compression parameters such as weight variation, hardness,

thickness, friability, drug content, uniformity of drug content and in-vitro dissolution

indicated that the prepared tablets were well within the specified standards.

 Fast dissolving tablets can be prepared by direct compression of the drug and suitable

concentration of super disintegrants along with other excipients.

 The formulation F9 containing combination of crospovidone and gellan gum showed the

99.40% of drug release within 10 minutes and disintegration time is 22 sec.

 Combination of superdisintegrants such as crospovidone and gellan gum showed rapid

and complete release.

 The formulation F12 containing combination of crospovidone and sterculia gum showed

the 99.08% of drug release within 10 minutes and disintegration time is 16 sec.

 Combination of superdisintegrants such as crospovidone and sterculia also showed rapid

and complete release.

Department of Pharmaceutics, Mallige college of pharmacy, Bangalore Page 123

CHAPTER-7 CONCLUSION

 The formulation F9 is considered as best formulation as the ratio of natural and synthetic

polymer is equal and showed 99.40% drug release.

 Formulation F9 followed first order kinetics, which revealed that the drug release rate of

the immediate release of tablets is concentration independent.

 The formulation F9 was selected for stability studies on the basis of their better and

satisfactory evaluation studies parameters. Result showed that there was not much

variation in physical parameters even after the periods of 90 days.

 From the results obtained, it was concluded that formulation F9 containing combination

of crospovidone and gellan gum are found to be stable and retained their original

properties during study period.

 Accelerated stability studies for 3 months proved the integrity of the developed Fast

dissolving tablets.

Department of Pharmaceutics, Mallige college of pharmacy, Bangalore Page 123