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Chapter-5 Results PDF
Chapter-5 Results PDF
Graph No.2: Study of dissolution data using different release kinetics models of formulation (F1)
R² = 0.8058 R² = 0.7825
80 1.85
60 Higuchi kinetics 1.8 Peppas kinetics
40 1.75
Linear (Higuchi Linear (Peppas
20 1.7
kinetics) kinetics)
0 1.65
0 2 4 6 0 0.5 1 1.5 2
√T Log T
Graph No.3: Study of dissolution data using different release kinetics models of formulation (F2)
2 y = 0.2454x + 1.5062
R² = 0.548
80 R² = 0.5193
1.9
60 Higuchi kinetics Peppas kinetics
40 1.8
Linear (Higuchi 1.7 Linear (Peppas
20
kinetics) kinetics)
0 1.6
0 2 4 6 0 0.5 1 1.5 2
Time Log T
Graph No.4: Study of dissolution data using different release kinetics models of formulation (F3)
R² = 1 1 y = -0.0878x + 1.48
100 R² = 1
80 0.5
Zero order
60 First order kinetics
kinetics 0
40 0 5 10 15 20 25 30 35
Linear (Zero order -0.5 Linear (First order
20
kinetics) kinetics)
0 -1
0 5 10 15 20 25 30 35
-1.5
Time Time
80 R² = 1 2.02 R² = 1
60 Higuchi kinetics 2.01 Peppas kinetics
2
40
1.99
20 Linear (Higuchi Linear (Peppas
1.98
kinetics) kinetics)
0 1.97
0 2 4 6 0 0.5 1 1.5 2
√T Log T
Graph No.5: Study of dissolution data using different release kinetics models of formulation (F4)
y = -0.0217x + 1.8033
100 y = 1.3236x + 47.809 1.5 R² = 0.9636
80 R² = 0.9786
60 1 First order kinetics
Zero order kinetics
40
0.5 Linear (First order
20 Linear (Zero order kinetics)
0 kinetics) 0
0 5 10 15 20 25 30 35 0 5 10 15 20 25 30 35
Time Time
Graph No.6: Study of dissolution data using different release kinetics models of formulation (F5)
2
Zero order kinetics First order kinetics
Graph No.7: Study of dissolution data using different release kinetics models of formulation (F6)
R² = 0.9772 R² = 0.856
100 1
Zero order kinetics First order kinetics
50 0.5
Linear (Zero order Linear (First order
0 kinetics) 0
kinetics)
0 5 10 15 20 25 30 35 0 5 10 15 20 25 30 35
-0.5
Time Time
Graph No.8: Study of dissolution data using different release kinetics models of formulation (F7)
Graph No.9: Study of dissolution data using different release kinetics models of formulation (F8)
Graph No.10: Study of dissolution data using different release kinetics models of formulation (F9)
Graph No.11: Study of dissolution data using different release kinetics models of formulation (F10)
Graph No.12: Study of dissolution data using different release kinetics models of formulation (F11)
Graph No.13: Study of dissolution data using different release kinetics models of formulation (F12)
y = 0.3922x + 1.3255
80 y = 13.501x + 8.5702 2
R² = 0.9345
R² = 0.9591
60 1.5
Higuchi kinetics Peppas kinetics
40 1
20 Linear (Higuchi 0.5 Linear (Peppas
kinetics) kinetics )
0 0
0 2 4 6 0 0.5 1 1.5 2
√T Log T
Graph No.14: Study of dissolution data using different release kinetics models of formulation (F13)
Graph No.15: Study of dissolution data using different release kinetics models of formulation (F14)
Graph No.16: Study of dissolution data using different release kinetics models of formulation (F15)
Graph No.17: Study of dissolution data using different release kinetics models of formulation (F16)
Graph No.18: Study of dissolution data using different release kinetics models of formulation (F17)
Graph No.19: Study of dissolution data using different release kinetics models of formulation (F18)
Table No.51: Differents kinetic models of fast dissolving tablet of Montelukast Sodium
Code Zero order First order Higuchi Peppas
2 2 2
R R R R2
F1 0.9338 0.9352 0.9075 0.8709
F2 0.8729 0.7668 0.8058 0.7825
F3 0.6342 0.5017 0.548 0.5193
F4 1 1 1 1
F5 0.9786 0.9636 0.9665 0.9359
F6 0.9524 0.9798 0.9685 0.9627
F7 0.9772 0.856 0.9943 0.9996
F8 1 1 1 1
F9 1 1 1 1
F10 0.9661 0.8537 0.9247 0.8982
F11 0.9699 0.9749 0.9848 0.9703
F12 1 1 1 1
F13 0.9895 0.9494 0.9591 0.9345
F14 0.9731 0.7329 0.9284 0.8941
F15 0.9582 0.7937 0.9159 0.8647
F16 0.9715 0.8038 0.9307 0.7685
F17 0.9801 0.9594 0.9865 0.9784
F18 0.8837 0.9308 0.9389 0.9675
120 120
100 100
Cum. % drug release
20 F3 20 F6
0 0
0 10 20 30 40 0 10 20 30 40
Time Time
Graph No. 20: Drug release profile (F1-F3) Graph No. 21: Drug release profile (F4-F6)
120 120
100 100
Cum. % drug release
60 F7 60 F10
40 F8 40 F11
F9 F12
20 20
0 0
0 10 20 30 40 0 10 20 30 40
Time Time
Graph No. 22: Drug release profile (F7-F9) Graph No. 23: Drug release profile (F10-F12)
120 120
100 100
Cum. % drug release
20 F15 20 F18
0 0
0 10 20 30 40 0 10 20 30 40
Time
Time
Graph No. 24: Drug release profile (F13-F15) Graph No. 25: Drug release profile (F16-F18)
Stability studies
The tablets formulation F9 was evaluated for different properties after three months of storage in accelerated temperature and
pressure. There is no change in colour and order of the tablets. Other properties are given in the following table.
Formulation F9
Table No.53: In vitro drug release study for stability testing of formulation F9 at 40˚ C±2
0 0
5 92.83±0.012
10 98.99±0.013
15 -
20 -
25 -
30 -
120
100
60
Before
After
40
20
0
0 5 10 15 20 25 30 35
Time
Graph No. 26. In-Vitro Drug Release of F9 Before Stability And After Stability at ˚C