GUJARAT TECHNOLOGICAL UNIVERSITY

CHEMICAL ENGINEERING (05)

ADVANCED SEPARATION TECHNIQUES
SUBJECT CODE: 2160507
B.E. 6th SEMESTER

Type of course: Chemical Engineering.

Prerequisite: None.

Rationale: Separation techniques are integral unit operation in most of the modern chemical,
pharmaceutical and other process plants. There are many standard and conventional separation
techniques available in the market and these techniques are quite common and the relevant technologies
as well as well developed and well studied. On the other hand, newer separation processes, like,
membrane based techniques, chromatographic separation, super critical fluid extraction, etc., are
gaining importance in modern days plants. The present course is designed to emphasize on these novel
separation processes. The course is designed for an elective subject of final year undergraduate
students.

Teaching and Examination Scheme:

Teaching Scheme Credits Examination Marks Total

L T P C Theory Marks Practical Marks Marks
ESE PA (M) ESE (V) PA
(E) PA ALA ESE OEP (I)
4 0 2 6 70 20 10 20 10 20 150

L- Lectures; T- Tutorial/Teacher Guided Student Activity; P- Practical; C- Credit; ESE- End

Semester Examination; PA- Progressive Assessment

Content:
Sr. No. Topic Teaching Weightage
Hours (%)
1. Super Critical Extraction 06 08
Working Principal, Advantage & Disadvantages of supercritical
solvents over conventional liquid solvents, Advantage &
Disadvantages of supercritical extraction over liquid- liquid
extraction, Decaffeination, ROSE process, Commercial
applications of supercritical extraction.
2. Short path Distillation: 06 08
Concept & working of short path Distillation Unit (SPDU),
Difference between short path Distillation & molecular
distillation, applications of SPDU.
3. Reactive & Catalytic Distillation: 07 10
Concept, Advantage & Disadvantages, BALE & KATMAX
packingManufacturing of MTBE and ETBE and it’s
comparision with conventional techniques.
 4. Pressure Swing Distillation: 04 6
Concept & Working, Advantage & Disadvantages of PSD over
azeotropic and Extractive Distillation, Applications
5. Membrane separation technique: 08 11
Principles, mechanisms, cross flow, membrane materials and
various membrane modules used in membrane separation
processes, Classification, application & advantages of
membrane separation processes.
6. Pressure Swing Adsorption: 07 10
Concept & Working, Advantages & Disadvantages of PSA over
cryogenic distillation, four step PSA, six step PSA, Purification
of hydrogen, oxygen, Nitrogen & other commercial applications
of PSA.
7. Melt crystallization: 06 8
Concept, phase equilibrium, different techniques, commercial
applications
8. Reverse Osmosis: 06 9
Concept of osmosis and reverse osmosis, different types of
membrane modules and membrane material for R.O.,
Advantages and commercial applications of R.O.
9. Ultrafiltration and nano filtration: 08 10
Concept & working principal ultrafiltration Vs Conventional
filtration, Ultrafiltration membranes and modules, Commercial
applications of ultrafiltration and nano filtration.
10. Pervaporization: 05 7
Working principal, Advantages, Production of absolute alcohol
and other commercial applications.
11. Membrane Reactor: 05 7
Concept & working, Various modules of membrane used for
membrane reactor, Advantages & Disadvantages, applications
under research
12. Membrane or Osmotic Distillation: 04 6
Working Principal, Various applications, etc.

Text Books:
1. “Membrane separation Processes” by Kaushik Nath, PHI pvt. Ltd., 2008
2. “Introduction to process Engineering & Design” by S.B. Thakore & B.I Bhatt, Tata McGraw-Hill
Ltd.,2007

Reference Books:
1. Perry Chemical Engineers Handbook’ 7th Edition by R.H Perry and D. Green.
2. Ullman’s Encyclopedia of Industrial Chemistry.
3. “Encyclopedia of Chemical Engineering” by Kirk & Othmer.
4. “Natural Extracts using supercritical carbon dioxide” M. Mukhopadhyay
Suggested Specification table with Marks (Theory):

Distribution of Theory Marks

R Level U Level A Level N Level E Level C Level
14 21 21 7 7 0
Legends: R: Remembrance; U: Understanding; A: Application, N: Analyze and E: Evaluate C:
Create and above Levels (Revised Bloom’s Taxonomy)

Note: This specification table shall be treated as a general guideline for students and teachers. The actual
distribution of marks in the question paper may vary slightly from above table.

Course Outcome: After learning the course the students should be able:

1. To built advanced concepts of separation techniques used in chemical industries.

2. To understand the principles and functioning advanced separation techniques.
3. To utilize the advanced separation technique in problem solving where conventional techniques are
not fruitful and require replacement.
4. To understand the applications of advanced separation techniques as per industrial requirement..
5. To recognize the selection criteria between advanced separation techniques and conventional
separation techniques.

List of Experiments:

Minimum 5 practicals to be performed and remaining time should be allotted to open-ended

projects/study reports/latest outcomes in technology study:-

1. In the beginning of the academic term, faculties will have to allot their students at least one
Open-ended Project / Study Report /Latest outcome in technology.
2. Literature survey including patents and research papers of fundamental process
- Design based small project or
- Study report based on latest scientific development or
- Technology study report/modeling/ simulation/collection report or
- Computer based simulation/web based application/analysis presentations of basic concept field
which may help them in chemical engineering.
3. These can be done in a group containing maximum three students in each.
4. Faculties should cultivate problem based project to enhance the basic mental and technical level of
students.
5. Evaluation should be done on approach of the student on his/her efforts (not on completion) to
study the design module of given task.
6. In the semester student should perform minimum 5 set of experiments and complete one small open
ended dedicated project based on engineering applications. This project along with any performed
experiment should be EVALUATED BY EXTERNAL EXAMINER.

List of Practicals:

1. Perform separation techniques using reactive distillation.

 2. Perform separation using membrane modules.
3. Perform separation techniques using supercritical extraction
4. Preparation of membrane modules for reverse osmosis.
5. Perform separation techniques using short path distillation.

Design based Problems (DP)/Open Ended Problem:

Open Ended projects in Advanced analytical techniques may include:

1. Review chart of application of advanced separation techniques in process industries.

2. Fabrication of reactive catayltic distillation unit.
3. Fabrication of short path distillation.
4. Fabrication and perfomance evaluation of different types of filtration membranes,
5. Fabrication of membrane module

List of Open Source Software/learning website:

 Students can refer to video lectures available on various websites including NPTEL.
 Students can refer to the CDs which are available with some reference books for the solutions of
problems using softwares. Students can develop their own programs for the solutions using excel,
Chemical and other simulation softwares.

ACTIVE LEARNING ASSIGNMENTS:

Preparation of power-point slides, which include videos, animations, pictures, graphics for better
understanding theory and practical work – The faculty will allocate chapters/ parts of chapters to groups
of students so that the entire syllabus to be covered. The power-point slides should be put up on the
web-site of the College/ Institute, along with the names of the students of the group, the name of the
faculty, Department and College on the first slide. The best three works should submit to GTU.
Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER– VI (New) EXAMINATION – WINTER 2019
Subject Code: 2160507 Date: 11/12/2019
Subject Name: Advance Separation Techniques
Time: 02:30 PM TO 05:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Explain concept of Sort Path Distillation Unit (SPDU). 03

(b) Explain working principle and various advantages of Pervaporization. 04
(c) Explain in detail with neat flow diagram: Manufacturing process of MTBE by 07
reactive distillation
Q.2 (a) Discuss various membrane materials for Reverse Osmosis (RO). 03
(b) Discuss Advantages & disadvantages of Pressure Swing Distillation (PSD) over 04
azeotropic and extractive distillation.
(c) Explain in detail about various membrane modules used in membrane separation 07
processes.
OR
(c) Explain in detail: Different techniques of Melt crystallization 07
Q.3 (a) Discuss various applications of membrane reactor. 03
(b) Explain working principle of membrane or osmotic distillation. 04
(c) Explain working principle of super critical extraction. Discuss advantages and 07
disadvantages of super critical extraction over liquid-liquid extraction.
OR
Q.3 (a) State various applications of Pressure Swing Distillation (PSD). 03
(b) Differentiate: Short path distillation & molecular distillation 04
(c) Explain in detail with neat flow diagram: Decaffeination of coffee 07
Q.4 (a) Discuss various commercial applications of pervaporization in brief. 03
(b) Explain Concept of osmosis and reverse osmosis. 04
(c) Discuss principle of Pressure Swing Adsorption (PSA) with its commercial 07
applications in detail.
OR
Q.4 (a) State various applications of membrane or osmotic distillation. 03
(b) Explain concept and working of membrane reactor. 04
(c) Write in detail about four step Pressure Swing Adsorption (PSA) process. 07
Q.5 (a) Discuss various applications of Melt Crystallization in brief. 03
(b) Discuss with neat sketch: BALE and KATMAX packing for reactive and 04
catalytic distillation
(c) Explain working principle of ultrafiltration and compare it with conventional 07
filtration.
OR
Q.5 (a) State various applications of short path distillation unit (SPDU). 03
(b) Give detail classification of membrane separation techniques. 04
(c) Discuss commercial applications of ultrafiltration and nano filtration in detail. 07

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Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER–VI(NEW) – EXAMINATION – SUMMER 2019
Subject Code: 2160507 Date: 18/05/2019
Subject Name: Advance Separation Techniques
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS

Q.1 (a) List the chemicals commonly used as supercritical solvent. 03

(b) Explain the commercial applications of short path distillation process 04
(c) Explain the concept of Reactive Distillation with a neat flowsheet and its 07
application.
Q.2 (a) Compare short path distillation with molecular distillation. 03
(b) What are the essential properties of a good supercritical solvent? 04
(c) Discuss the Advance separation techniques applied in chemical industry 07
and their benefits with example.
OR
(c) Describe the manufacturing of ETBE by Reactive Distillation process. 07
And compare with the conventional process.
Q.3 (a) List all the membrane based separation processes. 03
(b) Draw flow sheet of batch super critical extraction. 04
(c) Explain in detail the purification of hydrogen using six bed Pressure 07
Swing Adsorption (PSA) technique.
OR
Q.3 (a) List the advantages of PSA over cryogenic distillation. 03
(b) Explain the concept of Melt Crystallization. 04
(c) Discuss principal of pressure swing Adsorption with one industrial 07
application in details.
Q.4 (a) Draw a neat sketch of a cross-flow membrane process. 03
(b) Define Nanofiltration and Explain factors affecting Nanofiltration. 04
(c) Explain the concept of Reverse Osmosis (RO) and discuss in detail the use 07
of RO in desalination process.
OR
Q.4 (a) Discuss working principle of Reverse Osmosis. 03
(b) Write short note on Membrane cleaning. 04
(c) Discuss working principle of Ultra Filtration and its industrial 07
applications.
Q.5 (a) Write short note on membrane distillation. 03
(b) Explain the working of a membrane reactor. 04
(c) Write with neat sketch about different Modules used in membrane 07
separation.
OR
Q.5 (a) Write commercial applications of Pervaporation. 03
(b) Write short note on Nanofiltration. 04
(c) Explain the concept of Pervaporation and describe in detail the 07
manufacturing of MTBE by using pervaporation with neat sketch.

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Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER–VI (NEW) EXAMINATION – WINTER 2018
Subject Code:2160507 Date:30/11/2018
Subject Name:Advance Separation Techniques
Time: 02:30 PM TO 05:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) List commercial application of melt crystallization 03
(b) List the advantages of membrane separation techniques. 04
(c) Explain in detail concept and working of short path distillation unit process. 07

Q.2 (a) List all applications of membrane distillation process. 03

(b) Explain four step of pressure swing adsorption with an example. 04
(c) Explain the principal of supercritical extraction using ROSE process. 07
OR
(c) List out all commercial applications of supercritical extraction. 07
Q.3 (a) Define with an example a membrane separation technique. 03
(b) Discuss the phase equilibrium diagram of melt crystallization. 04
(c) Explain the various aspect of reactive and catalytic distillation over the 07
conventional distillation
OR
Q.3 (a) List commercial application of pressure swing adsorption. 03
(b) Explain BALE packing and KATMAX packing. 04
(c) Explain in detail the different method of melt crystallization. 07
Q.4 (a) Give the disadvantages of supercritical extraction over liquid-liquid 03
extraction.
(b) List out all commercial applications of reverse osmosis. 04
(c) Clarify the advantages & disadvantages of pressure swing distillation over 07
azeotropic and extractive distillation.
OR
Q.4 (a) Explain the reverse osmosis process. 03
(b) Discuss in detail the de-caffination process. 04
(c) Explain working of pressure swing distillation and list its applications. 07

Q.5 (a) Explain concept and working of nanofiltration. 03

(b) Explain membranes modules used in membrane reactor. 04
(c) List all commercial application of pervaporiation and ultra filtration. 07
OR
Q.5 (a) Explain concept and working of ultrafiltration. 03
(b) Discuss with an example the working principal of osmotic distillation. 04
(c) Explain the pervaporization method for the production of absolute alcohol. 07

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Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER–VI (NEW) - EXAMINATION – SUMMER 2018
Subject Code:2160507 Date:05/05/2018
Subject Name:Advance Separation Techniques
Time:10:30 AM to 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

MARKS
Q.1 (a) Define SCE with it’s advantages and disadvantages. 03
(b) Explain concept of Pressure Swing Distillation (PSD). 04
(c) Explain ROSE process for deasphalting with a neat sketch. 07

Q.2 (a) Compare short path distillation with molecular distillation. 03

(b) Write a short note on packing elements used for catalytic distillation 04
(c) Discuss the Advance separation techniques applied in chemical 07
industry and their benefits with example.
OR
(c) Explain flow sheet of Decaffeination of coffee? 07

Q.3 (a) What are the essential properties of a good supercritical solvent? 03
(b) List the advantages & disadvantages of PSA over cryogenic 04
distillation.
(c) Discuss principal of pressure swing Adsorption with one industrial 07
application in details.
OR
Q.3 (a) List the major applications of short path distillation process. 03
(b) What are the advantages of reactive distillation? 04
(c) Describe the manufacturing process of ETBE by reactive distillation 07
with a neat process flow sheet.

Q.4 (a) Discuss the concept of SPDU. What is the use of roller wiper system 03
in a SPDU?
(b) List down the applications of pervaporization. 04
(c) Discuss about the different techniques used for Melt crystallization? 07
OR
Q.4 (a) Name some commonly used membrane materials. 03
(b) Write a short note on ultrafiltration. 04
(c) Explain working of pressure swing distillation? What is difference 07
between Melt crystallization and distillation?

Q.5 (a) Classify the membrane process based on driving force 03

(b) List the membrane modules and explain any one in detail. 04
(c) Write working principle and applications of Osmotic Distillation 07
OR
Q.5 (a) Draw a neat sketch of a cross-flow membrane process. 03
(b) What is driving force for RO process? Also discuss working principle 04
of Reverse Osmosis.
(c) Write a short note on pervaporization. 07

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Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER–VI (NEW) EXAMINATION – WINTER 2017
Subject Code: 2160507 Date: 16/11/2017
Subject Name:Advance Separation Techniques
Time:02:30 PM TO 05:00PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

MARKS
Q.1 (a) List all the membrane based separation processes. 03
(b) Explain the importance of separation techniques in chemical industry. 04
(c) Explain ROSE process for deasphalting with a neat sketch. 07

Q.2 (a) Describe the different types of packings used in reactive distillation 07
process.
(b) Describe a short path distillation unit with a neat sketch. 07
OR
(b) Explain the process of separation of air by pressure swing adsorption. 07

Q.3 (a) List the chemicals commonly used as supercritical solvent and their 03
properties.
(b) List the commercial applications of short path distillation process. 04
(c) Explain the concept of pressure swing distillation and compare PSD with 07
azeotropic distillation.
OR
Q.3 (a) Explain nanofiltration process and its application in detail. 07
(b) Describe the manufacturing process of MTBE by reactive distillation with 07
a neat process flow sheet.

Q.4 (a) Explain pervaporation technique and its application. 07

(b) Explain in detail melt crystallization process with a neat sketch of 07
equipment.
OR
Q.4 (a) Explain reverse osmosis process and its application in desalination of sea 07
water.
(b) Compare pressure swing adsorption with cryogenic distillation and their 07
advantages and disadvantages.

Q.5 (a) Answer in brief: 08

(i) List the various methods to reduce membrane fouling.
(ii) Describe an asymmetric type membrane.
(b) Write a short note on membrane reactor. 06
OR
Q.5 (a) Answer in brief: 08
(i) List the commonly used membrane manufacturing materials.
(ii) Application of ultrafiltration process.
(b) Write a short note on membrane modules. 06

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 Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER–VI (NEW) - EXAMINATION – SUMMER 2017
Subject Code: 2160507 Date: 05/05/2017
Subject Name: Advance Separation Techniques
Time: 10:30 AM to 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 Short Questions 14

1 List commonly used super critical solvents.

2 Name the packing elements used for catalytic distillation.
3 What is the use of roller wiper system in a SPDU?
4 Which process is used for manufacture of MTBE?
5 Which process is used for decaffenation of coffee?
6 What is disadvantage of H2O as supercritical fluid?
7 Which process is used for separation of heat sensitive products?
8 Which are the processes used for separation of air?
9 List the membrane modules.
10 Name some commonly used membrane material.
11 What is driving force for RO process?
12 What is MWCO? What is its unit?
13 Give examples of concentration driven membrane process.
14 Name the membrane process used for dehydration of alcohol.

Q.2 (a) What are the advantages of reactive distillation? 03

(b) What are the essential properties of a good supercritical solvent? 04
(c) Explain ROSE process for deasphalting with a neat sketch. 07
OR
(c) Explain the process of purification of gases by pressure swing adsorption. 07

Q.3 (a) Compare short path distillation with molecular distillation. 03

(b) List the advantages & disadvantages of PSA over cryogenic distillation. 04
(c) Describe the manufacturing process of ETBE by reactive distillation with 07
a neat process flow sheet.
OR
Q.3 (a) Classify the membrane process based on driving force. 03
(b) List the major applications of short path distillation process. 04
(c) Explain the concept of pressure swing distillation. Compare PSD with 07
azeotropic distillation.

Q.4 (a) Draw a neat sketch of a cross-flow membrane process. 03

(b) Write short note on nanofiltration. 04
(c) Explain in detail melt crystallization process with a neat sketch of 07
equipment.

1
 OR

Q.4 (a) Write short note on membrane distillation. 03

(b) List the commercial application of melt crystallization process. 04
(c) Explain the concept and working of a membrane reactor. 07

Q.5 (a) Describe in brief a spiral wound membrane module. 03

(b) What is membrane fouling and how it can be mitigated? 04
(c) Explain the basic principle of pervaporation and its commercial 07
applications.
OR
Q.5 (a) What is concentration polarization? 03
(b) Describe a thin film composite membrane with diagram. 04
(c) Explain reverse osmosis process and its application in desalination. 07

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 Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE – SEMESTER – VI (NEW).EXAMINATION – WINTER 2016

Subject Code: 2160507 Date: 26/10/2016

Subject Name: Advance Separation Techniques
Time: 02:30 PM to 05:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Discuss the Advance separation techniques applied in chemical industry 07
and their benefits with example
(b) Define SCE? Explain flow sheet of batch super critical extraction? 07

Q.2 (a) Explain flow sheet of Decaffeination of coffee? 07

(b) Explain working of Short Path Distillation unit. 07
OR
(b) Explain with neat flow sheet: ROSE Process. 07

Q.3 (a) Discuss principal of pressure swing Adsorption with one industrial application 07
in details.
(b) Explain working of pressure swing distillation? What is difference between 07
Melt crystallization and distillation?

OR
Q.3 (a) Discuss about the different techniques used for Melt crystallization? 07
(b) Write in detail about four step pressure swing adsorption process. 07

Q.4 (a) Write with neat sketch about different Modules used in membrane separation 07
(b) Discuss the concept and working of membrane reactor and their application 07

OR
Q.4 (a) Discuss technique of per vaporization with its industrial application 07
(b) Discuss in detail various engineering problems associated with usage of 07
membranes.

Q.5 (a) Discuss working principle of Reverse Osmosis and its industrial applications 07
(b) Write working principle and applications of Osmotic Distillation. 07

OR
Q.5 (a) Write in details about reactive and catalytic distillation and discuss BALE and 07
KATMAX packing with neat sketch.
(b) Explain Ultra filtration with its industrial applications. 07

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1
 Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER–VI (NEW) - EXAMINATION – SUMMER 2016
Subject Code:2160507 Date:17/05/2016
Subject Name: Advance Separation Techniques
Time: 10:30 AM to 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Explain Residuum Oil Supercritical Extraction (ROSE) process with a neat 07
flowsheet. Describe the advantages of this process over conventional propane
deasphalting process
(b) Explain the concept of Reactive Distillation and with a neat flowsheet .Describe 07
the manufacturing of ETBE by Reactive Distillation process
Q.2 (a) Explain working of Short Path Distillation unit in detail with a neat sketch 07
indicating all the components of the unit.
(b) Explain concept of Pressure Swing Distillation(PSD). Also describe the working of 07
PSD for the separation of the Acetonitrile-Water sytem.
OR
(b) Discuss in detail the various contact devices used for catalytic distillation 07

Q.3 (a) Describe different types of membrane modules with neat sketch used in membrane 07
separation process.
(b) Explain in detail the purification of hydrogen using six bed Pressure Swing 07
Adsorption (PSA) technique.
OR
Q.3 (a) Explain Ultrafiltration. List down its applications. 07
(b) Explain the concept of Melt Crystallization and explain its applications. 07

Q.4 (a) Explain the concept of Reverse Osmosis (RO) and discuss in detail the use of RO 07
in various water purification and desalination process.
(b) List down the various applications of Short Path Distillation and give a detailed 07
description of any one application
OR
Q.4 (a) Explain the concept of Pervaporation and describe in detail the manufacturing of 07
absolute alcohol by using pervaporation.
(b) Explain the working principle of osmotic distillation and describe its various 07
applications.
Q.5 (a) Discuss the concept and working of membrane reactors and their applications. 07
(b) List the Supercritical Solvents. Discuss importance of supercritical solvents and the 07
principle of Supercritical Extraction
OR
Q.5 (a) Explain the advantages and limitations of the various new separation techniques 07
used in the chemical industries over conventional methods.
(b) Discuss in detail various engineering problems associated with usage of membranes 07

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