The Effects of Omega-3 Supplementation on Hypertriglyceridemia in Adults:

A Systematic Review
Timeframe
P: Adults between 40-70
RCT 1: 12 weeks
years old with high
RCT 2: 8 weeks
triglycerides
RCT 3: 12 weeks
I: 2-4 gm daily of oral
RCT 4: 8 weeks
omega-3 supplementation Average Age Interventions
# Participants
C: compared to a placebo RCT 1: 2gm daily omega-3 fatty acid
RCT 1: 49-50.3 y.o.
O: in serum triglyceride RCT 1: 162 vs. olive oil placebo
RCT 2: 60.4-63.6 y.o.
levels RCT 2: 120 RCT 2: 2 capsules BID re-esterified
RCT 3: 58-63 y.o. n-3 PUFA vs. 2 capsules BID 1000mg
T: over at least 8 weeks RCT 3: 215
RCT 4: 54 y.o. EE-PUFA vs. 2 capsules BID olive oil
RCT 4: 253
placebo
RCT 3: 4gm daily oral icosapent
Starting triglyceride levels: ethyl omega-3 vs. placebo
RCT 4: 1gm Omacor BID + low fat
150-2500 mg/dL diet vs. 2gm Omacor BID + low fat
diet vs. olive oil placebo + low fat
diet

Results Results
Significant decrease in triglycerides with omega-3 Decrease in LDL-C
14.2% 22% 21.4% 32.1%
Increase in omega-3 index
28% 21.5% 29.7%

A SYSTEMATIC REVIEW BY MONICA MOORE RD, LD UNIVERSITY OF NEW ENGLAND: APN 760
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