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    Parkinson's disease is characterized by the loss of dopamine-producing neurons in the substantia nigra pars compacta region of the midbrain. This leads to a reduction in dopamine levels in the striatum, which causes motor symptoms such as tremors, rigidity, slowness of movement, and difficulty with walking and balance. Neuroinflammation and the activation of microglia are also involved in the pathogenesis of Parkinson's disease.

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    Parkinson's disease is characterized by the loss of dopamine-producing neurons in the substantia nigra pars compacta region of the midbrain. This leads to a reduction in dopamine levels in the striatum, which causes motor symptoms such as tremors, rigidity, slowness of movement, and difficulty with walking and balance. Neuroinflammation and the activation of microglia are also involved in the pathogenesis of Parkinson's disease.

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    Jellinger K

    Uploaded by

    chica_as
    Parkinson's disease is characterized by the loss of dopamine-producing neurons in the substantia nigra pars compacta region of the midbrain. This leads to a reduction in dopamine levels in the striatum, which causes motor symptoms such as tremors, rigidity, slowness of movement, and difficulty with walking and balance. Neuroinflammation and the activation of microglia are also involved in the pathogenesis of Parkinson's disease.

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    Jellinger K. 2014. Neuropathology of Parkinson’s Disease.

    Inflammation in Parkinson’s Disease:


    Scientific and Clinical Aspects; 36-40.

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