{In the name of Allah the merciful the compassionate }

Biochemistry
Questions
&
Answers
A-Naeem Al-sawaie
Jordanian University of Science and Technology (JUST)
Medicine & surgery –MD
1. The key enzyme in the regulation of fatty acid synthesis is
A. acetyl CoA carboxylase

B. AMP activated proteinkinase

C. protein phosphatase

D. none of these
ANS:A
2. Arachidonate has 20 carbon atoms with
A. 3 double bonds

B. 2 double bonds

C. 4 double bonds

D. 8 double bonds
ANS:C
3. In the intestine, the dietary fats are hydrolysed by
A. triacylglycerol lipase

B. adenylate cyclase

C. pancreatic lipase

D. protein kinase
ANS:C
VLDLs are synthesized in
A. blood

B. liver

C. intestine

D. pancreas
ANS: B
5. Triacylglycerols are
A. soluble in water

B. insoluble in water

C. soluble in water at elevated temperature

D. partially soluble in water

 Answer: Option B

6. Animals cannot convert fatty acids into glucose because

A. acetyl CoA can not be converted to pyruvate

B. absence of malate synthase

C. absence of dehydrogenase

D. absence of a-ketoglutarate dehydrogenase

Answer: Option A
7. In eukaryotes fatty acid breakdown occurs in
A. mitochondrial matrix

B. cytosol

C. cell membrane

D. endoplasmic reticulum
Answer: Option A
8. Phospholipid contains
A. hydrophilic heads and hydrophobic tails

B. long water-soluble carbon chains

C. positively charged functional groups

D. both (b) and (c)

Answer: Option A
9. Micelles of fatty acids in water are organized such that the __________ faces the solvent and
the __________ are directed toward the interior
A. carboxylic acid groups, hydrocarbon chains heads

B. hydrophilic heads, hydrophobic tails

C. hydrocarbon chains, carboxylic acid groups

D. both (a) and (b)

Answer: Option D
10. Chylomicrons are synthesized in
A. blood

B. liver

C. intestine

D. pancreas
Answer: Option C
11. Fatty acid synthesis takes place in
A. mitochondria

B. cell membrane

C. cytosol

D. endoplasmic reticulum
Answer: Option C
12. Cholestrol is the precursor of
A. steroid hormones

B. vitamin A

C. bile salts

D. both (a) and (c)

Answer: Option D

13. Palmitate has 16 carbon atoms with

A. 2 double bonds

B. 3 double bonds

C. One double bond

D. None of these
Answer: Option D
14. How many ATPs are formed during complete oxidation of palmitate?
A. 35

B. 96

C. 129

D. 131
Answer: Option C
15. Synthesis of fatty acid takes place when
A. fatty acid are plentiful

B. carbohydrate is plentiful

C. carbohydrate and energy are plentiful

D. none of these
Answer: Option C

16.The irreversibility of the thiokinase reactions (formation of initial acyl-CoA)

A. make this activation reaction the committed step on the pathway
 B. is due to the subsequent hydrolysis of the product

C. applies only to even-chain fatty acids

D. both (a) and (b)

Answer: Option D

17. Long-chain fatty acids are oxidized step-wise in one carbon units starting from the
A. carboxyl end

B. aliphatic end

C. both (a) and (b)

D. none of these
Answer: Option A

“Note : the aliphatic end is the terminal

methyl end of fatty acid chain”
18. How many molecules of acetyl-CoA are produced in oxidation of palmitic acid (C16), which
involves seven rounds of oxidation?
A. 6

B. 7

C. 8

D. 9
Answer: Option C

19.The maximum energy per gram on oxidization is yielded from

A. fat

B. protein

C. glycogen

D. starch
Answer: Option A

20.Each cycle of β-oxidation produces

A. 1 FADH2, 1 NAD+, and 1 acetyl-CoA

B. 1 FADH2, 1 NADH and 1 acetyl-CoA

C. 1 FADH2, 1 NADH and 2 CO2 molecules

 D. 1 FAD, 1 NAD+ and 2 CO2 molecules
Answer: Option B

21.Where the acyl-CoA formed in the cytosol is transported for oxidation?

A. Mitochondrial matrix

B. Microsomes

C. Endoplasmic reticulum

D. Remains in cytosol
Answer: Option A
22.The transport of acyl-CoA for oxidation using a shuttle involves formation of the intermediate
A. 3 acetyl-CoA

B. Acyl-coenzyme A

C. acyl-carnitine

D. None of these
Answer: Option C
23.ketone bodies are synthesized in

A.liver

B.kidney

C.heart

D.brain
Answer: Option A
24.enzyme common to synthesis of cholesterol and ketone bodies

A.HMG CoA Lyase

B.HMG CoA reducrase

C.HMG CoA synthase

D.esterase
Answer: option C
25.ketone bodies are metabolic end products of

A.fats

B.carbohydrates

C.proteins
D.all of them

Answer:option A

26.ketosis is associated with which of the following:

A.starvation

B.prolonged fasting

C.heavy exercise

D.more fat utilization

E.DM-1
F.two answers are correct
G.all of them are correct
H.non of above is correct
Answer: option G

27. all statements regarding ketone bodies are

correct except
A.they may result from starvation

B.they may be excreted in urine

C.formed only in kidney

D.increased in uncontrolled DM-1

Answer:C

28.Carnitine involved in B –oxidation is synthesized

from
A.lysine

B.serine

C.arginine

D.choline
Answer: A
29-B-Oxidation of odd-chain fatty acid produce:

A.succinyl-CoA

B.Acetyl CoA

C.propionyl CoA
D.Malonyl CoA

E. two answers are correct

Answer: E
DONE BY : A-Neem Al-Sawaie

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