BPharm-VI semester

Medicinal chemistry-III
Multiple Choice Questions-II (for practice session)
(Unit I and II)
1. Piperacillin is an example of
a. amino penicillin
b. penicillinase resistant
c. Ureidopenicillin
d. natural penicillin
2. Oxytetracycline is obtained from
a. Streptomyces rimosus
b. S.aureofaciens
c. S.kanamyceticus
d. S. tenebrarious
3. Substitution with OH/polar group at C-5 in tetracycline
a. Improves water solubility
b. decreases lipophilicity
c. Improves oral administration
d. All the above
4. Which of the following is not semisynthetic penicillin?
a. Cloxacillin
b. Procaine penicillin
c. Ampicillin
d. Carbenicillin
5. Features of clindamycin include the following:
a. It is primarily active against aerobic gram negative bacilli
b. It can be used topically to treat infected acne vulgaris
c. It is not absorbed orally
d. It is used to treat pseudomembranous enterocolitis
6. Which of the following is the general mechanism of action for erythromycin?
a. Inhibition of a metabolic enzyme
b. Inhibition of cell wall synthesis
c. Disruption of protein synthesis
d. Inhibition of nucleic acid transcription and replication
7. The following general structure is representative of sulphonamides. Which of the
following statements is true for active sulphonamides?

a. R1 can be H or an alkyl group

b. R2 must be hydrogen
c. The aromatic ring is essential
d. The sulphonamide functional group can be replaced with an ester
8. What is the target for clavulanic acid?

a. transpeptidase enzyme
b. L-ala racemase
c. β-lactamase
d. Penicillin acylase
9. Grey baby syndrome is associated with
a. chloramphenicol
b. doxycycline
c. erythromycin
d. Streptomycin
10. The following structure is a synthetic antibacterial agent.

a. Aminoacridines
b. Aminoglycosides
c. Fluoroquinolones
d. Tetracyclines
11. What role does the acetoxy group at the 3-position of cephalosporins have in enhancing
antibacterial activity?
a. It acts as a steric shield and masks enzymatic attack at the β-lactam ring.
b. It acts as a good leaving group when the β-lactam ring is opened.
c. It takes part in a transesterification reaction with the carboxylic acid group at
position 4.
d. It increases the reactivity of the β-lactam ring by neighbouring group
participation.
12. What crucial feature of a penicillin is involved in its mechanism of action?
a. Carboxylic acid
b. β-lactam ring
c. Acyl side chain
d. Thiazolidine ring
13. The following structure (cefalexin) is a first generation cephalosporin.

Which of the following statements is true for the methyl substituent at position 3?
a. It is a good leaving group
b. It is generally good for activity
c. It is good for oral activity
d. It acts as a steric shield
14. What reaction is catalysed by a β-lactamase enzyme?
a. The final cross-linking reaction to form the bacterial cell wall
b. The hydrolysis of the acyl side chain from penicillin structures
c. The hydrolysis of the four-membered ring present in penicillins
d. The biosynthesis of the penicillin structure from the amino acids valine and
cysteine

15.

The molecule shown is:

a. levofloxacin
b. ofloxacin
c. nalidixic acid
d. ciprofloxacin
16. Roxithromycin has the following advantages over erythromycin:
a. It is more effective in whooping cough
b. It causes less gastric irritation
c. I has longer half life
d. Both B and C are correct.
17. Which of the following is prodrug?
a. Nimesulide
b. Indomethacin
c. Diclofenac
d. Nabumetone
18. Prodrugs with two active compounds are known as
a. Mixed type prodrugs
b. Pro-prodrugs
c. Bioprecursors
d. Mutual prodrug
19. Erythrocytic scizontocide anti-malarial drugs are used as
a. Suppressive prophylactic
b. Clinical curative
c. Radical curative for P.Vivax
d. Both A and B
20. The following drug is a causal prophylactic for falciparum malaria and suppressive
prophylaxis for vivax malaria
a. Chloroquine
b. Mepacrine
c. Quinine
d. Proguanil
21. Select the correct statement about primaquine:
a. It has no role in falciparum malaria
b. It is used as a gametocidal drug in falciparum malaria
c. It is combined with chloroquine to treat resistant P.falciparum infection
d. it is used to prevent recrudescence of falciparum malaria
22. Which of the following antibiotic is a first line drug for treatment of M.avium complex
infection in AIDs patients?
a. Clindamycin
b. Clarithromycin
c. Roxithromycin
d. Erythromycin
23. Which of the following is not a semisyntheic penicillin?
a. Cloxacillin
b. Procaine penicillin
c. Ampicillin
d. Carbenicillin
24. Select the class of antibiotic which act by interfering with bacterial protein synthesis
but as bactericidal:
a. Tetracycline
b. Aminoglycoside
c. Cephalosporin
d. Lincosamide
25. Which antibiotic is primarily bacteriostatic but bactericidal at high concentration?
a. Erythromycin
b. Tetracycline
c. Chloramphenicol
d. None of the above
26. The advantage(s) of erythromycin estolate over erythromycin
a. Less bitter taste
b. acid stable in stomach
c. Good absorption profile
d. All the above
27. Example of bioprecursor prodrug is :
a. Cyclophosphamide
b. Pivampicillin
c. Progabide
d. Becampicillin
28. Methinamine is a prodrug of
a. Formaldehyde
b. Mechloromethamine
c. Metaprolol
d. Mannitol
29. Fluroquinlones are indicated for all of the following except
a. Urinary tract infection
b. Tuberculosis
c. Bone infection
d. Bronchial asthma
30. The macrolide antibiotics do not have
a. a large lactone ring
b. a glycosidically linked amino sugar
c. a spiroketal group
d. a ketone group