CATHOLIC UNIVERSITY OF HEALTH AND

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MEDICINAL CHEMISTRY QUESTIONS

1. Phenoxybenzamine is described as representing a “chemical sympathectomy

because of its selective blockade of the excitatory responses of smooth muscle and of

the heart muscle

a. Give structure and classification of the drug

b. Mention 3 uses

c. And give detailed mechanism of action The α -adrenoreceptor blocking

agents.

2. Prazosin Hydrochloride U.S.P is A quinazoline derivative with value in the

management of hypertension

a. Give structure and classification of the drug

b. Explain why its Is an antagonist with added advantages comparable to

others.

c.

3. CARVEDIOL is Mixed α/β adrenergic blockers give structure and explain SARS

for mixed action

4. isosorbide which is basically a bicyclic form of sorbitol and is used orally to reduce

intraocular pressure in glaucoma cases.give structure of both compound and explain

how they work to reduce pressure.

5. Timolol is Non selective β-blocker approved in 1978 for with no significant

membrane- stabilizing (local nesthetic) action or intrinsic

sympathomimeticactivity.The aromatic side is different from other -antagonists but

the side chain is structurally identical Give structure of the drug and uses 3

6. Explain why aryloxypropanolamine β-Blockers binds on the same receptors with

aryloxypropanolamineβ-Blockers